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Braz. j. microbiol ; 48(2): 208-210, April.-June 2017. graf
Article in English | LILACS | ID: biblio-839387


Abstract This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed. After the resection surgery, the patient did not need to use an antifungal drug to treat the phaeohyphomycosis, and no follow-up radiotherapy was needed to treat the squamocellular carcinoma. We stress that the presence of the squamocellular lesion of the lip was a possible contributing factor to the infection.

Humans , Female , Aged, 80 and over , Lip Neoplasms/complications , Carcinoma, Squamous Cell/complications , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/pathology , Lip/pathology , Brazil , Lip Neoplasms/surgery , Carcinoma, Squamous Cell/surgery , Microbiological Techniques , Treatment Outcome , Phaeohyphomycosis/surgery , Histocytochemistry , Lip/surgery , Microscopy
An. bras. dermatol ; 91(1): 89-92, Jan.-Feb. 2016. graf
Article in English | LILACS | ID: lil-776416


Abstract Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp. emphasizing the clinical variability of the disease, as well as diagnostic and therapeutic difficulties of this opportunistic infection in immunosuppressed patients (kidney transplant).

Humans , Male , Middle Aged , Exophiala/isolation & purification , Kidney Transplantation/adverse effects , Phaeohyphomycosis/pathology , Antifungal Agents/therapeutic use , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Opportunistic Infections/immunology , Opportunistic Infections/pathology , Opportunistic Infections/therapy , Phaeohyphomycosis/immunology , Phaeohyphomycosis/therapy , Skin/pathology
An. bras. dermatol ; 89(4): 649-651, Jul-Aug/2014. graf
Article in English | LILACS | ID: lil-715523


Phaeohyphomycosis is a disease caused by dematiaceous fungi with a worldwide geographic distribution and broad spectrum. It is most commonly found in adult individuals of both genders and all races. We report the case of a 57-year-old woman with phaeohyphomycosis in the ungual apparatus.

Female , Humans , Middle Aged , Nail Diseases/microbiology , Phaeohyphomycosis/microbiology , Skin/microbiology , Antifungal Agents/therapeutic use , Nail Diseases/drug therapy , Nail Diseases/pathology , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/pathology , Skin/pathology , Treatment Outcome
An. bras. dermatol ; 89(1): 169-170, Jan-Feb/2014. graf
Article in English | LILACS | ID: lil-703553


Subcutaneous phaeohyphomycosis is an infection caused by dematiaceous fungi which mainly affects immunosuppressed patients. We report a case of subcutaneous phaeohyphomycosis on the back of the left hand in a kidney transplant patient who had been taking prednisone, tacrolimus, and azathioprine daily for 3 years.

Humans , Female , Middle Aged , Phaeohyphomycosis/pathology , Hand Dermatoses/pathology , Biopsy , Immunosuppression/adverse effects , Kidney Transplantation , Immunocompromised Host , Phaeohyphomycosis/surgery , Hand Dermatoses/surgery
Mem. Inst. Oswaldo Cruz ; 107(7): 854-858, Nov. 2012. ilus
Article in English | LILACS | ID: lil-656039


The goal of this study was to review 18 cases of phaeohyphomycosis in Rio Grande do Sul. The records of all of the patients with a diagnosis of phaeohyphomycosis between 1995-2010 were reviewed. Twelve of the 18 patients (66.6%) were male. The average age of the patients was 50 years old (range: 16-74 years). Eleven patients (61%) presented with subcutaneous lesions. Seven patients (38.8%) had received a solid organ transplant. In all of the cases, the presence of melanin in the fungal cells was determined by Fontana-Masson staining of tissue sections and documented. Among the 18 patients, a total of 11 different fungal species were isolated. The causative organisms included Exophiala jeanselmei, Alternaria, Curvularia, Cladophialophora and Colletotrichum gloeosporioides. To our knowledge, this review reports the first case of subcutaneous phaeohyphomycosis caused by C. gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency.

Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Phaeohyphomycosis/epidemiology , Brazil/epidemiology , Central Nervous System Fungal Infections/diagnosis , Central Nervous System Fungal Infections/epidemiology , Central Nervous System Fungal Infections/microbiology , Central Nervous System Fungal Infections/pathology , Dermatomycoses/diagnosis , Dermatomycoses/epidemiology , Dermatomycoses/microbiology , Dermatomycoses/pathology , Immunocompromised Host , Lung Transplantation , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/microbiology , Phaeohyphomycosis/pathology , Retrospective Studies