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Rev. medica electron ; 42(5): 2398-2407, sept.-oct. 2020. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1144743


RESUMEN Se presentó el caso de un paciente masculino de 60 años, blanco, que fue atendido en la Consulta de Oftalmología, del Hospital "Dr. Mario Muñoz", del municipio de Colón, provincia de Matanzas. Refirió que llevaba aproximadamente 20 días, con sensación de cuerpo extraño en el ojo izquierdo, enrojecimiento, secreción constante, fotofobia y una lesión que le había aumentado de tamaño durante este período; la que se tornaba dolorosa durante el parpadeo. Se decidió realizar este trabajo con el objetivo de mostrar los beneficios obtenidos al concluir el tratamiento aplicado a este tipo de tumor (AU).

ABSTRACT The authors present the case of a white male patient, aged 60 years, who assisted the Consultation of Ophthalmology of the Hospital "Dr. Mario Muñoz", of the municipality of Colon. He referred feeling a foreign body in the left eye for already 20 days, presence of redness, constant secretion, photophobia and a lesion that had grown during that period, painful when blinking. The authors decided to write this article with the objective of showing the benefits obtained with the applied treatment in this kind of tumor (AU).

Humans , Male , Adult , Signs and Symptoms , Carcinoma, Squamous Cell/epidemiology , Ophthalmology/methods , Carcinoma, Squamous Cell/surgery , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/diagnosis , Eye Foreign Bodies/complications , Eye Foreign Bodies/diagnosis , Risk Factors , Cornea/abnormalities , Photophobia/complications , Photophobia/diagnosis
Arq. neuropsiquiatr ; 77(3): 161-165, Mar. 2019. tab
Article in English | LILACS | ID: biblio-1001338


ABSTRACT Tension-type headaches (TTH) and irritable bowel syndrome (IBS) are comorbid diseases affecting, especially, women. One of the underlying mechanisms for both is autonomic dysfunction in the brain-gut axis. We aimed to evaluate the factors accompanying TTH and their relation to functional gastrointestinal disorders. Methods: Women diagnosed with TTH were questioned about headache pattern and severity, and accompanying factors, as well as being screened for IBS according to the Rome III criteria. The participants were divided into two groups: constipation-dominant IBS (IBS-C) group and "others", with a total of 115 individuals included in the study. Results: Of the 115 patients; 48 (41.8%) of the women had IBS-C criteria while 67 (58.2%) described mixed-type IBS or diarrhea-dominant IBS. There were no significant differences in terms of mean age (p = 0.290), body mass index (p = 0.212), visual analog scale (p = 0.965), duration of attacks (p = 0.692), and episodic/chronic type (p = 0.553). Osmophobia was seen in 43.5%; phonophobia in 68.7%, and photophobia in 47.0% of the patients, and only osmophobia was significantly associated in women in the IBS-C group (p = 0.001). Conclusion: In female patients with TTH, a higher level of constipation was detected. The relationship of these two diseases suggests that they may share common mechanisms. This is the first study showing the relationship of osmophobia with constipation.

RESUMO As cefaléias do tipo tensional (TTH) e a síndrome do intestino irritável (IBS) são comorbidades que afetam especialmente as mulheres. O mecanismo subjacente para ambas é a disfunção autonômica no eixo cérebro-intestino. Nosso objetivo foi avaliar os fatores que acompanham as TTH e sua relação com distúrbios gastrointestinais funcionais (FGID). Métodos: Mulheres com diagnóstico de TTH foram questionadas quanto ao padrão e gravidade da cefaleia, fatores acompanhantes e triadas para IBS de acordo com os critérios de Roma III e foram divididas em dois grupos: grupo com IBS com predominância de constipação (IBS-C) e as demais. Um total de 115 mulheres foram incluídas no estudo. Resultados: Do total de 115 pacientes; 48 (41,8%) das mulheres tiveram os critérios da IBS-C, enquanto 67 (58,2%) tiveram IBS do tipo misto ou IBS com predominância de diarreia. Não houve diferenças significativas em termos de idade média (p = 0,290), índice de massa corporal (IMC) (p = 0,212), escala visual analógica (VAS) (p = 0,965), duração dos ataques (p = 0,692), e tipo episódico / crônico (p = 0,553). Osmofobia foi observada em 43,5% das pacientes; fonofobia em 68,7% e fotofobia em 47,0%, e apenas osmofobia foi significativamente associada no grupo de mulheres com predominância de constipação (p = 0,001). Conclusão: Em pacientes do sexo feminino com TTH, encontra-se uma maior constipação. A relação dessas duas doenças sugere que elas podem compartilhar mecanismos comuns. Além disso, este é o primeiro estudo mostrando a relação da osmofobia com a constipação.

Humans , Female , Adult , Middle Aged , Tension-Type Headache/complications , Constipation/complications , Irritable Bowel Syndrome/complications , Hyperacusis/physiopathology , Severity of Illness Index , Pain Measurement , Body Mass Index , Prospective Studies , Surveys and Questionnaires , Tension-Type Headache/physiopathology , Constipation/physiopathology , Photophobia/physiopathology , Irritable Bowel Syndrome/physiopathology
Article in Korean | WPRIM | ID: wpr-766779


Intracranial hypotension usually arises in the context of known or suspected leak of cerebrospinal fluid (CSF). This leakage leads to a fall in intracranial CSF pressure and CSF volume. The most common clinical manifestation of intracranial hypotension is orthostatic headache. Post-dural puncture headache and CSF fistula headache are classified along with headache attributed to spontaneous intracranial hypotension as headache attributed to low CSF pressure by the International Classification of Headache Disorders. Headache attributed to low CSF pressure is usually but not always orthostatic. The orthostatic features at its onset can become less prominent over time. Other manifestations of intracranial hypotension are nausea, spine pain, neck stiffness, photophobia, hearing abnormalities, tinnitus, dizziness, gait unsteadiness, cognitive and mental status changes, movement disorders and upper extremity radicular symptoms. There are two presumed pathophysiologic mechanisms behind the development of various manifestations of intracranial hypotension. Firstly, CSF loss leads to downward shift of the brain causing traction on the anchoring and supporting structures of the brain. Secondly, CSF loss results in compensatory meningeal venodilation. Headaches presenting acutely after an intervention or trauma that is known to cause CSF leakage are easy to diagnose. However, a high degree of suspicion is required to make the diagnosis of spontaneous intracranial hypotension and understanding various neurological symptoms of intracranial hypotension may help clinicians.

Brain , Cerebrospinal Fluid , Cerebrospinal Fluid Leak , Classification , Diagnosis , Dizziness , Fistula , Gait , Headache , Headache Disorders , Hearing , Intracranial Hypotension , Movement Disorders , Nausea , Neck Pain , Photophobia , Post-Dural Puncture Headache , Spine , Tinnitus , Traction , Upper Extremity , Ventriculoperitoneal Shunt
Article in English | WPRIM | ID: wpr-764340


BACKGROUND AND PURPOSE: Cluster headache (CH) can present with migrainous symptoms such as nausea, photophobia, and phonophobia. In addition, an overlap between CH and migraine has been reported. This study aimed to determine the differences in the characteristics of CH according to the presence of comorbid migraine. METHODS: This study was performed using data from a prospective multicenter registry study of CH involving 16 headache clinics. CH and migraine were diagnosed by headache specialists at each hospital based on third edition of the International Classification of Headache Disorders (ICHD-3). We interviewed patients with comorbid migraine to obtain detailed information about migraine. The characteristics and psychological comorbidities of CH were compared between patients with and without comorbid migraine. RESULTS: Thirty (15.6%) of 192 patients with CH had comorbid migraine, comprising 18 with migraine without aura, 1 with migraine with aura, 3 with chronic migraine, and 8 with probable migraine. Compared to patients with CH without migraine, patients with CH with comorbid migraine had a shorter duration of CH after the first episode [5.4±7.4 vs. 9.0±8.2 years (mean±standard deviation), p=0.008], a lower frequency of episodic CH (50.0% vs. 73.5%, p=0.010), and a higher frequency of chronic CH (13.3% vs. 3.7%, p=0.033). Psychiatric comorbidities did not differ between patients with and without comorbid migraine. The headaches experienced by patients could be distinguished based on their trigeminal autonomic symptoms, pulsating character, severity, and pain location. CONCLUSIONS: Distinct characteristics of CH remained unchanged in patients with comorbid migraine with the exception of an increased frequency of chronic CH. The most appropriate management of CH requires clinicians to check the history of preceding migraine, particularly in cases of chronic CH.

Classification , Cluster Headache , Comorbidity , Headache , Headache Disorders , Humans , Hyperacusis , Migraine Disorders , Migraine with Aura , Migraine without Aura , Nausea , Photophobia , Prospective Studies , Specialization
Distúrb. comun ; 29(1): 77-85, mar. 2017.
Article in Portuguese | LILACS | ID: biblio-880681


Este estudo objetiva analisar textos produzidos por um sujeito de 10 anos de idade, do sexo masculino, diagnosticado com Síndrome de Irlen (SI). Trata-se de um relato de um estudo de caso, pesquisa qualitativa, de cunho sócio-histórico. Priorizou-se a análise de aspectos discursivos e notacionais das produções escritas, relacionadas a quatro gêneros discursivos: uma carta (para um ídolo, para um familiar ou para um amigo), regras de um jogo, um conto infantil e um cartaz. Em relação aos aspectos discursivos, o participante da pesquisa conseguiu operar sobre vários aspectos que caracterizam as condições de produção dos gêneros requeridos, evidenciando pertinência em relação às temáticas propostas, à finalidade e ao contexto de circulação do texto. Quanto aos aspectos notacionais, o sujeito apresentou estratégias e hipóteses distantes do padrão ortográfico da língua, tais como: trocas, omissões e acréscimo de letras e segmentação indevida. Os resultados evidenciam que crianças com esse diagnóstico podem apresentar estratégias singulares em suas produções, inerentes ao processo de apropriação da linguagem escrita. Diante da análise realizada, sugere-se o implemento de estudos acerca da referida síndrome que ofereçam elementos para que profissionais da saúde e educação, envolvidos com sujeitos acometidos pela mesma, possam em suas práticas clínicas e escolares desenvolver um trabalho que priorize os processos e as diferentes dimensões envolvidas com a apropriação da leitura e da escrita.

The objective of this study was to analyze different texts produced by a 10-year-old male individual diagnosed with Irlen Syndrome (IS). This is a case report; a socio-historical qualitative study. The analysis focused on the discursive and notational aspects of the production of four different writing genres: a letter (to an idol, a family member, or a friend), the rules of a game, a children's story, and a poster. Regarding the discursive aspects, the participant was able to adequately operate the various aspects that characterize the production of the required genres, showing relevance concerning the proposed themes, objectives, and context flow. As for the notational aspects, the subject presented hypotheses and strategies that were distant from the orthographic pattern of the target language, such as changes, omissions, increase of letters and undue segmentation. The results show that children diagnosed with IS may have unique strategies, inherent to the appropriation process of written language. Based on the analysis, it is suggested that studies on IS are conducted, so that they may offer elements for health and education professionals involved with these individuals in their clinical and school practices to conduct their jobs prioritizing the processes and different dimensions involved with the appropriation of reading and writing skills.

Este estudio tiene por objetivo analizar producciones escritas por un sujeto de 10 años de edad, de sexo masculino, diagnosticado con el Síndrome de Irlen (SI). Se trata un estudio de caso, investigación cualitativa, de carácter socio-histórico. Se ha priorizado el análisis de los aspectos discursivos y notacionales de las producciones escritas relacionadas con cuatro géneros discursivos: Una carta (a su ídolo, a un miembro de la familia o a un amigo), reglas de un juego, un cuento infantil y un póster. En cuanto a los aspectos discursivos, el participante de la investigación consiguió operar bajo diversos aspectos que caracterizan las condiciones de producción de los géneros requeridos, evidenciando pertinencia para los temas propuestos, la finalidad y el contexto de circulación del texto. En cuanto a los aspectos notacionales, el sujeto presentó estrategias y hipótesis distantes de la ortografía estandarizada, tales como: cambios, omisiones y adición de letras y segmentación inadecuada. Los resultados indican que los niños con este diagnóstico pueden desarrollar estrategias únicas en sus producciones, inherentes al proceso de apropiación de la lengua escrita. Ante el análisis realizado, se sugiere el implemento de estudios acerca del síndrome que ofrezcan elementos con los cuales profesionales de la salud y educación, involucrados con los individuos afectados, puedan en sus prácticas clínicas y escolares desarrollar un trabajo que da prioridad a los procesos y a las diferentes dimensiones relacionadas con la apropiación de la lectura y escritura.

Humans , Male , Child , Asthenopia , Depth Perception , Language , Language Disorders , Photophobia , Speech, Language and Hearing Sciences
Article in Korean | WPRIM | ID: wpr-56978


PURPOSE: To report a rare case of traction retinal detachment and retinal ischemia in inactive Takayasu's arteritis at ophthalmologic clinic. CASE SUMMARY: A 23-year-old woman presented with a floater, photophobia, and visual loss in her right eye one week prior to visit. She had no other systemic disease, such as diabetes mellitus or hypertension, or previous ophthalmic abnormalities except for a tumor in the adrenal gland. We found bilateral retinal ischemia and traction retinal detachment in the right eye on fundus examination without iris neovascularization. Pars plana vitrectomy, traction removal, endolaser treatment, and intravitreal bevacizumab injection were performed. Steroid eye drops and steroid systemic administration relieved the inflammation. On carotid doppler sonography, we found severe stenosis and thickness of the inner layer in both carotid arteries. We diagnosed the patient with an inactive phase of Takayasu's arteritis, which was conclusively correlated with the clinical features. Vascular anastomosis surgery along with follow-up was proposed by both the cardiology and vascular surgery departments. CONCLUSIONS: When a young patient presents with traction retinal detachment and retinal ischemia, Takayasu's arteritis should be considered for differential diagnosis and a systemic work-up should be performed as soon as possible.

Adrenal Glands , Bevacizumab , Cardiology , Carotid Arteries , Constriction, Pathologic , Diabetes Mellitus , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Hypertension , Inflammation , Iris , Ischemia , Ophthalmic Solutions , Photophobia , Retinal Detachment , Retinaldehyde , Takayasu Arteritis , Traction , Vitrectomy , Young Adult
Article in Korean | WPRIM | ID: wpr-9116


Epidemic keratoconjunctivitis is the most common type of infectious conjunctivitis, and is caused by adenoviruses. The mode of transmission is mainly through direct contact with ocular secretions. Epidemic keratoconjunctivitis is generally diagnosed based on a patient's clinical features, and additional measures, such as cell cultures, polymerase chain reaction, and rapid antigen detection tests, can further confirm the diagnosis. The most common symptoms include a foreign body sensation, tearing, and photophobia. The symptoms are usually expressed unilaterally in the initial phase, but gradually become bilateral. Frequently occurring complications include pseudomembrane formation and subepithelial infiltrates. Currently, no antiviral agent has been proven effective to alter the natural course of the disease, and treatment merely has a supportive role instead of a curative role. Therefore, preventive measures in medical offices and in the community are the most important methods of controlling the propagation of this disease.

Adenoviridae , Adenovirus Infections, Human , Cell Culture Techniques , Conjunctivitis , Conjunctivitis, Viral , Diagnosis , Foreign Bodies , Humans , Keratoconjunctivitis , Photophobia , Polymerase Chain Reaction , Sensation , Tears
Acta Medica Philippina ; : 79-85, 2017.
Article in English | WPRIM | ID: wpr-633387


BACKGROUND: Migraine is a highly common disorder that can cause significant disability on an individual, which collectively may lead to a substantial burden for the society. Various expert societies have recommended Acetaminophen/Aspirin/Caffeine (AAC) combination regimen as the first-line drug treatment for migraine attacks; however, there were no pooled evidences summarizing the effectiveness and tolerability of this regimen.OBJECTIVE: To determine the effectiveness and tolerability assessment of oral AAC combination regimen as an acute treatment for migraine in adults.METHODS: Relevant studies from inception to March 2014 were searched in Cochrane CENTRAL, MEDLINE, LILACS, Scopus and metaRegister of Controlled Trials. The Cochrane Collaboration's tool for the assessment of risk of bias was employed. Trials that were randomized, double-blind, parallel-group, placebo and active-controlled were included and the data were employed for meta-analysis. To evaluate the quality of evidence, the GRADE approach was utilized for outcomes with sufficient studies and data.RESULTS: From 225 records identified, 4 trials were included in this review, with a total of 3,608 participants with recorded baseline characteristics. Patient-reported migraine intensity was moderate-severe and the AAC dose used was at 500/500/130 mg. At 2 hours, AAC regimen was statistically different and found to be superior to placebo in terms of pain-free, headache relief, nausea-free, photophobia-free, phonophobia-free and functional disability reduction rates using intension-to-treat analysis. Missing data did not alter the outcome measures generating robust results. Sumatriptan 100 mg was found to be better than AAC in pain-free rate, and phonophobia-free rates at 2 hours. Statistically more patients in the AAC arm experienced "any adverse event" compared to placebo and complaints were commonly nausea and nervousness.CONCLUSION: For adult individuals with moderate-severe migraine, a fixed oral dose of Acetaminophen/Aspirin/Caffeine (AAC 500/500/130 mg) may be used as first-line therapy for the acute treatment of migraine and is only associated with mild, infrequent adverse events.

Humans , Male , Female , Adult , Acetaminophen , Sumatriptan , Caffeine , Photophobia , Hyperacusis , Aspirin , Migraine Disorders , Drug Combinations
Article in English | WPRIM | ID: wpr-59858


Cystinosis is a rare disease characterized by abnormal lysosomal cystine accumulation of cystine due to impaired lysosomal transport. We previously reported the first case of cystinosis in Korea in a 12-year-old boy with short stature, general weakness, and photophobia. The diagnosis was confirmed based on ophthalmic findings and biochemical analyses (serum leukocyte cystine measurement). Major endocrine manifestations at diagnosis included hypothyroidism, growth retardation, and hypogonadism. Despite oral cysteamine administration and renal replacement therapy, multiple complications including both endocrine and nonendocrine disorders developed during and after adolescence. In this report, we review the presenting features and factors related to the long-term complications in a patient with cystinosis.

Adolescent , Child , Cysteamine , Cystine , Cystinosis , Diagnosis , Humans , Hypogonadism , Hypothyroidism , Korea , Leukocytes , Lysosomal Storage Diseases , Male , Photophobia , Rare Diseases , Renal Replacement Therapy
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2016; 26 (1): 68-69
in English | IMEMR | ID: emr-175807


This is a case report about the anterior segment findings of epithelial ingrowth in a young female patient after penetrating trauma. The patient underwent multiple surgeries after penetrating trauma and epithelial ingrowth was noted on regular follow-up. Epithelial ingrowth was noted along the inner surface of corneal endothelium along with the presence of cysts. These findings suggest that epithelium penetrated through the site of perforation and grew along endothelium. Although epithelial ingrowth is a commonly reported complication of photorefractive surgery, it is rarely reported after trauma to eye. To authors' knowledge, this is the first reported case of epithelial ingrowth in Pakistan

Humans , Female , Young Adult , Wounds, Penetrating , Endothelium, Corneal , Epithelium , Anterior Eye Segment , Pain , Photophobia
Dermatol. argent ; 22(1): 19-26, 2016. ilus, tab
Article in Spanish | LILACS | ID: biblio-859118


Las ictiosis hereditarias son un grupo de desórdenes mendelianos, con manifestaciones clínicas y alteraciones genéticas heterogéneas caracterizadas por la presencia de escamas y/o hiperqueratosis. Las ictiosis sindrómicas son aquellas en las que el defecto genético se manifiesta en la piel y también en otros órganos. Presentamos 7 pacientes con ictiosis sindrómicas: un síndrome IFAP (ictiosis folicular, atriquia, fotofobia), un síndrome de Conradi-Hünermann-Happle (CHH), dos síndromes de Netherton (SN), dos síndromes de Sjögren-Larsson (SSL) y un síndrome KID (queratitis, ictiosis, sordera). Se analizan las características clínicas y diagnósticas de nuestros pacientes (AU)

Inherited ichthyosis are a group of clinical and genetic heterogeneous disorders characterized by the presence of scales, hyperkeratosis or both. In syndromic ichthyosis, the genetic defect involves the skin and other organs. We present 7 patients with syndromic ichthyosis: a case of IFAP syndrome (ichthyosis follicularis with alopecia and photophobia), a case of Conradi-Hünermann-Happle (CHH) syndrome, two cases of Netherton syndrome, two cases of Sjögren-Larsson syndrome and a case of KID syndrome (keratitis, ichthyosis and deafness). We analyze the diagnostic and clinical features of our patients (AU)

Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Ichthyosis/etiology , Ichthyosis/pathology , Alopecia , Ichthyosis, X-Linked , Netherton Syndrome , Photophobia , Sjogren-Larsson Syndrome
Article in Korean | WPRIM | ID: wpr-159671


PURPOSE: To report a case of migraine attacks with aura that occurred after percutaneous closure of an atrial septal defect (ASD) with the Amplatzer septal occluder device. CASE SUMMARY: A 58-year-old female presented with glare and scintillation that lasted 3 days. She had a history of percutaneous ASD intervention 3 weeks prior. Because ophthalmologic examination revealed nothing remarkable, the patient underwent observation. However, two months later, she revisited our department, presenting with aggravated glare, scintillation, and severe photophobia. Also, she presented with scintillation followed by a headache starting from the right temporal area extending to the occipital area. The patient was diagnosed with migraine with aura, which was newly developed after percutaneous ASD closure. After switching medication from acetylsalicylic acid to clopidogrel, the frequency and intensity of the headaches were reduced. No recurrence of ophthalmic symptoms or headache was observed during the 1-year follow-up. CONCLUSIONS: Percutaneous closure of ASD can be complicated by the appearance of migraine attacks with aura. When patients present with glare and scintillation, ophthalmologists must consider the possibility of migraine with aura and migraine induced by secondary causes. Thus, detailed history taking should be taken in order to make an early diagnosis of migraine.

Aspirin , Early Diagnosis , Epilepsy , Female , Follow-Up Studies , Glare , Headache , Heart Septal Defects, Atrial , Humans , Middle Aged , Migraine Disorders , Migraine with Aura , Photophobia , Recurrence , Septal Occluder Device
Arq. neuropsiquiatr ; 72(12): 949-953, 02/12/2014. tab
Article in English | LILACS | ID: lil-731038


Migraine is a central nervous system disorder frequently expressed with paroxysmal visual dysfunctions. Objective To test the hypothesis that normal visual input is vital for the migrainous aura and photophobia. Method We studied the migraine-related visual disturbances in 8 sightless migraineurs identified among 200 visually impaired subjects. Results The main findings were the visual aura and photophobia disappearance along with blindness development, the oddness of aura – too short, colourful (e.g. blue or fire-like), auditory in nature or different in shape (round forms) – and the lack of photophobia. Conclusion We propose that the aura duration should be accepted as shorter in visually impaired subjects. The changes in aura phenotype observed in our patients may be the result of both cerebral plasticity induced by the visual impairment and/or the lack of visual input per se. Integrity of visual pathways plays a key role in migraine visual aura and photophobia. .

A enxaqueca é doença neurológica frequentemente associada a anormalidades visuais transitórias. Objetivo Testar a hipótese de que a visão normal é importante para o fenótipo da aura e da fonofobia. Método Estudamos 8 enxaquecosos deficientes visuais identificados em uma população de 200 indivíduos com visão subnormal. Resultados Os principais achados foram: o desaparecimento da aura visual e da fotofobia com o início da cegueira; a ocorrência de aura atípica – muito curta, colorida (p. ex. azul ou cor de fogo) auditiva ou diferente na forma (arredondadas); e a ausência de fotofobia. Conclusão Propomos que a duração da aura possa ser admitida como mais curta em pessoas com deficiência visual. As mudanças no fenótipo da aura observadas nos nossos pacientes pode ser o resultado da plasticidade cerebral induzida pela deficiência visual e/ou a deficiência visual em si. A integridade da via visual desempenha um papel crucial na aura enxaquecosa e na fotofobia. .

Adult , Female , Humans , Male , Middle Aged , Blindness/physiopathology , Migraine with Aura/physiopathology , Photophobia/physiopathology , Age of Onset , Epilepsy/physiopathology , Time Factors
Rev. cuba. oftalmol ; 27(4): 626-632, oct.-dic. 2014. ilus
Article in Spanish | LILACS, CUMED | ID: lil-746400


La distrofia de Cogan es la distrofia corneal anterior más común, frecuente en adultos del sexo femenino, entre 40-70 años de edad. Presentamos un caso de una paciente de 50 años de edad, del sexo femenino, quien refiere visión borrosa, lagrimeo y fotofobia. Al examen de la córnea en lámpara de hendidura se observan imágenes de color grisáceo en forma de huellas dactilares y de mapa. Esta afección es causada por alteraciones de la membrana basal epitelial que provoca la separación parcial o total del epitelio corneal. Generalmente asintomática, es la causa más frecuente de erosión corneal recurrente. Las opciones terapéuticas varían desde lubricantes, soluciones hipertónicas tópicas, lentes de contacto de vendaje, desbridamiento del epitelio central, micropunciones mecánicas o diatermia y fotoqueratectomía con láser excímer.

Cogan's dystrophy is the most common anterior corneal dystrophy in adult females aged 40-70 years of age. Here is a 50 years-old female patient suffering from blurred vision, weeping eyes and photophobia. On examination, grayish images were observed in the form of fingerprints and map. This disease is caused by alterations of the epithelial basal membrane bringing about partial or total removal of the corneal epithelium. Often asymptomatic, it is the most common cause of recurrent corneal erosion. Treatment options range from lubricants, topical hypertonic solutions, bandage contact lenses, central epithelial debridement, mechanical or diathermy micropuncture and excimer laser photokeratectomy.

Humans , Female , Middle Aged , Basement Membrane/injuries , Photophobia/diagnosis , Corneal Surgery, Laser/statistics & numerical data , Retinal Dystrophies/diagnosis , Lubricant Eye Drops , Hypertonic Solutions
Salud(i)ciencia (Impresa) ; 20(5): 477-485, may.2014. tab
Article in Spanish | LILACS | ID: lil-790874


Estudiar la incidencia de queratitis infecciosas (QI) tras la cirugía refractiva con láser excimer (laser assisted in situ keratomileusis [LASIK] y ablación de superficie [AS]: LASEK y PRK) el diagnóstico, la actitud terapéutica adoptada, el manejo y los resultados. Material y método: Hemos realizado un estudio retrospectivo multicéntrico en 351 712 ojos intervenidos consecutivamente, de todos aquellos casos susceptibles de ser diagnosticados como QI por la clínica o los hallazgos biológicos. Resultado: Se recolectó un total de 147 casos de QI (lo que supone una incidencia del 0.0417%) ; en 100 casos lo fueron tras la LASIK (0.0307%) y 47 tras la AS (0.176%). La infección corneal se presentó en el 57.8% en el ojo derecho y en el 42.2% en el ojo izquierdo; en 12 pacientes la presentación fue bilateral. El tiempo transcurrido desde la cirugía LASIK hasta el comienzo de los síntomas fue de 16 ± 32 días, fue temprano en el 62%; tras la AS, fue a los 13 ± 26 días (rango: 1 a 160), el 71.79% se presentó en la primera semana. En 23 casos, tras la LASIK, de los 74 en los que se tomaron muestras, el resultado del cultivo fue positivo. Se tomaron muestras en 33 casos de la serie de AS, 15 de los cuales fueron positivos. En el grupo de LASIK, el 22% de los ojos perdió una o más líneas de su agudeza visual lejana corregida (CDVA), mientras que en el 53% de los ojos la visión final fue de 20/20 y en el 95% lo fue de 20/40 o mejor. En 31 ojos (66%) del grupo de AS se mantiene la CDVA; la visión final fue de 20/20 en el 54.7% y de 20/40 en el 93.6% de los ojos. Conclusiones: La incidencia de infección después de la LASIK es baja, pero la tasa de infección después de la AS es estadísticamente más elevada. La aparición de esta complicación en pacientes asintomáticos subraya la necesidad de revisiones posoperatorias. No hemos encontrado diferencias estadísticamente significativas entre la agudeza visual final tras infecciones después de AS y de LASIK...

Keratitis , Laser Therapy , Eye , Infections , Lacrimal Apparatus Diseases , Pain , Photophobia , Postoperative Complications
Pesqui. vet. bras ; 34(5): 427-432, May 2014. ilus
Article in English | LILACS | ID: lil-714712


Senecio spp. poisoning is the main cause of cattle mortality in the central region of Rio Grande do Sul. This paper reports an outbreak of seneciosis in cattle with high prevalence of photosensitization, where 83 out of 162 cows (51.3 percent) presented this clinical sign. The outbreak occurred in September 2013, affecting adult cows that were held in a 205 hectare-pasture from April to October 2013 with abundant Senecio brasiliensis infestation. Main clinical signs were weight loss, excessive lacrimation or mucopurulent ocular discharge, nasal serous discharge, ventral diphteric glossitis, crusts in the nose, teats, dorsum of ears, and vulva. Liver biopsy was performed in all the cows under risk; the histopathological findings in the liver biopsies consisted of fibrosis, megalocytosis, and biliary ductal proliferation and were present in 73.4 percent of the biopsied animals. Six cows had increased serum activity of gamma glutamyl transferase. Three affected cows were necropsied. The main necropsy findings were a hard liver, distended gall bladder, edema of the mesentery and abomasum. Liver histological changes in the necropsied cows were similar to those of the biopsied livers. Spongiosis was detected in the brain of necropsied cows and is characteristic of hepatic encephalopathy.

A intoxicação por plantas do gênero Senecio é a principal causa de morte de bovinos na região central do Rio Grande do Sul. Neste trabalho, relata-se um surto de intoxicação por Senecio brasiliensis em bovinos com alta prevalência de fotossensibilização, onde 83 vacas de um total de 162 (51,3 por cento) apresentaram esse sinal clínico. O surto ocorreu em setembro a outubro de 2013, acometendo vacas adultas que foram colocadas de abril a início de outubro de 2013 em um campo de 205 hectares com abundante infestação por Senecio brasiliensis. Os principais sinais clínicos foram emagrecimento, lacrimejamento excessivo ou secreção ocular mucopurulenta, secreção nasal serosa, glossite diftérica ventral e crostas no plano nasal, tetos, ponta das orelhas e na vulva. Realizou-se biópsia hepática em todas as vacas do rebanho; os principais achados histopatológicos nas bipósias hepáticas foram fibrose hepática, megalocitose e proliferação de ductos biliares. As lesões hepáticas foram observadas em 73,4 por cento dos bovinos submetidos à biópsia hepática. Seis vacas testadas apresentaram aumento da atividade sérica da gama glutamil transferase. Três vacas doentes foram necropsiadas. Nas vacas necropsiadas, o fígado era firme, a vesícula biliar distendida e havia edema do mesentério e do abomaso. As lesões histológicas observadas nos fígados dos bovinos necropsiados eram semelhantes às encontradas nas biópsias hepáticas. Espongiose foi detectada no cérebro das vacas necropsiadas e é uma lesão característica de encefalopatia hepática.

Animals , Female , Cattle , Photophobia/veterinary , Senecio/toxicity , Signs and Symptoms/veterinary , Autopsy/veterinary , Liver Cirrhosis/veterinary
Indian J Exp Biol ; 2014 Mar; 52(3): 281-290
Article in English | IMSEAR | ID: sea-150358


The trilobite larvae of C. rotundicauda were tested to determine their colour preference and light sensitivity until their first moulting (25 days post hatching) under laboratory conditions. Maximum congregation size of the trilobite larvae was found in the white zone respectively where (n= 12) followed by yellow (n= 8) and orange (n= 8), which showed the larval preference for lighter zones. Morisita’s index calculation showed a clumped/aggregated distribution (yellow, blue, orange and white) and uniform/hyper dispersed distribution (green, red and black) for various colours tested. Trilobite larvae showed least preference for brighter regions while tested in the experiment [black; (n=4) and red; (n=5)]. Experiments done to determine the light sensitivity of trilobite larvae showed that the larvae had more preference towards ultraviolet lights. The maximum congregation size of 38.8 and 40.7% of the larvae was encountered under ultraviolet light, when the light sources were kept horizontal and vertical, respectively. Overall, results suggested that the trilobite larvae of C. rotundicauda, preferred light source of shorter wavelengths (UV light) and colours of lighter zone (white, yellow, orange), which might be due to their adaptation to their natural habitat for predator avoidance, prey selection and water quality.

Animals , Color , Horseshoe Crabs/physiology , Larva/physiology , Photophobia , Ultraviolet Rays
Article in Korean | WPRIM | ID: wpr-69008


Spontaneous intracranial hypotension is a syndrome caused by cerebrospinal fluid (CSF) leakage from the spinal dural sac. The most common symptom is a postural headache and other clinical symptoms may include nausea, vomiting, photophobia, diplopia, dizziness, and tinnitus. Usually, conservative treatments like hydration, bed rest, and administration of caffeine are recommended first, but epidural blood patch is regarded as the mainstay of treatment in the patients who do not respond to conservative therapy. Epidural blood patch was known that it provides the tamponade and seal of dural sac when performed at the leak site. Our patient was suspected the CSF leakage at cervicothoracic junction, but epidural blood patch was performed in lumbar level and the headache of patient was managed successfully for at least 1 year.

Bed Rest , Blood Patch, Epidural , Caffeine , Cerebrospinal Fluid , Diplopia , Dizziness , Headache , Humans , Intracranial Hypotension , Nausea , Photophobia , Tinnitus , Vomiting
Article in Korean | WPRIM | ID: wpr-57684


PURPOSE: We report a case of treatment of acute central retinal artery occlusion (CRAO) with ocular ischemic syndrome (OIS). CASE SUMMARY: A 72-year-old man presented with acute loss of vision in the right eye on that day. At initial examination, visual acuity tested positive for light sensitivity in the right eye. Fundus examination demonstrated a visible embolus at the central retinal artery overlying the optic disc head and a cherry-red spot in the fovea. Fluorescein angiography revealed that filling of the choroidal circulation was delayed, and the arteriovenous transit time was even further delayed. Carotid angiography showed marked stenosis within the right internal carotid artery. Laboratory tests included blood tests for hypercoagulability evaluation, for which the results were non-specific. To treat acute CRAO with OIS in the right eye, transluminal Nd:YAG laser embolectomy (TYE) was performed twice, and carotid angioplasty with stenting was conducted within the stenosed internal carotid artery. One month after the TYE procedure and carotid stenting, the patient's visual acuity improved to 0.06 and the arteriovenous transit time was within normal limits on fluorescein angiography. CONCLUSIONS: The visual prognosis in eyes with CRAO plus an associated choroidal circulatory disturbance is extremely poor. However, we experienced and reported a case of CRAO with OIS treated successfully through a prompt TYE procedure and carotid angioplasty with stenting.

Aged , Angiography , Angioplasty , Carotid Artery, Internal , Choroid , Constriction, Pathologic , Embolectomy , Embolism , Fluorescein Angiography , Head , Hematologic Tests , Humans , Photophobia , Prognosis , Retinal Artery , Retinal Artery Occlusion , Stents , Thrombophilia , Visual Acuity