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1.
J. coloproctol. (Rio J., Impr.) ; 40(1): 67-72, Jan.-Mar. 2020. tab, ilus
Article in English | LILACS (Americas) | ID: biblio-1090840

ABSTRACT

Abstract Rationale: Considering that anal fistulae are still challenging regarding their treatment due to the risk of fecal incontinence in the most complex cases and the increasing use of phytotherapeutic drugs such as Aloe Vera in medicine, even with proven healing effectiveness, there is interest in researching this drug in the treatment of anal fistulae. Objective: To evaluate the efficacy of Aloe Vera extract in the treatment of anal fistulae in rats. Method: Thirty male Wistar rats weighing 250-300 g were submitted to anal fistula and after 30 days were divided into three groups: Control Group (GCo) (n = 5), Carbopol Group (GCa) (n = 5), and Aloe Vera Group (GAV) (n = 10). In the GCo no treatment was performed, while in the others a daily infusion of 0.3 mL of solution (Carbopol only in GCa and Carbopol plus Aloe Vera extract in the GAV) was performed through the external orifice of the fistula for 30 days. Afterwards, euthanasia was performed and specimens were removed for histological study. It was evaluated the closure of the fistulous tract, the area of the remaining tract, the inflammatory infiltrate and the degree of vascular congestion. The results were submitted to statistical treatment by Kruskall-Wallis test, considering p<0.05. Results: There was no complete closure of the fistulous tract in any of the animals. The mean area of the remaining tract was 847.2 µm in the GCo, 565.6 µm in the GCa and 377.8 µm in the GAV (p<0.05). The mean of the inflammatory infiltrate score was 2.4 in the GCo, 2.4 in the GCa and 2.3 in the GAV (p<0.05), while in the evaluation of vascular congestion, we observed a mean of 1.6 in the GCo, 1.4 in GCa and 1.1 in GAV (p<0.05). Conclusion: The extract of Aloe vera was able to reduce the lumen of the fistulous tract and reduce the degree of vascular congestion; however, it did not allow the complete closure of the fistulous tract nor diminished the inflammatory process.


Resumo Racional: Considerando que o tratamento das fístulas anais tem risco de incontinência fecal e o crescente uso do Aloe Vera na medicina, há interesse em se pesquisar este fármaco. Objetivo: Avaliar a eficácia do extrato de Aloe vera no tratamento das fístulas anais em ratos. Método: Utilizou-se 30 ratos Wistar, os quais foram submetidos à criação de fístula anal e após 30 dias distribuídos em três grupos: Controle (GCo), Carbopol (GCa) e Aloe Vera (GAV). No GCo nenhum tratamento foi realizado, enquanto nos outros realizou-se infusão diária de 0,3 mL de Carbopol GCa e Carbopol mais extrato de Aloe Vera no GAV por 30 dias. Foram retirados os espécimes para estudo histológico, avaliou-se o fechamento do trajeto fistuloso, a área do trajeto remanescente, o infiltrado inflamatório e o grau de congestão vascular. Resultados: Não houve fechamento completo do trajeto fistuloso em nenhum dos animais. A média da área do trajeto remanescente foi 847,2 µm no GCo; 565,6 µm no GCa e 377,8 µm no GAV (p<0,05). A média do escore de infiltrado inflamatório foi 2,4 no GCo; 2,4 no GCa e 2,3 no GAV (p<0.05), enquanto na avaliação da congestão vascular observou-se média 1,6 no GCo; 1,4 no GCa e 1,1 no GAV (p<0,05). Conclusão: O extrato de Aloe Vera foi capaz de diminuir o lumen dos trajetos fistulosos e reduzir o grau de congestão vascular, porém, não permitiu o fechamento completo dos trajetos fistulosos nem diminuiu o processo inflamatório.


Subject(s)
Animals , Rats , Rectal Fistula/drug therapy , Plant Preparations , Aloe , Aloe/drug effects , Phytotherapy , Plants, Medicinal , Rectal Fistula , Rats, Wistar
2.
J. coloproctol. (Rio J., Impr.) ; 40(1): 61-66, Jan.-Mar. 2020. tab, ilus
Article in English | LILACS (Americas) | ID: biblio-1090837

ABSTRACT

Abstract Rationale: Disuse colitis is frequent in our country and the most effective treatment is high cost and there is a need for effective and low cost therapy. Objective: To evaluate the efficacy of Baccharis dracunculifolia (field rosemary) in the treatment of exclusion colitis in rats. Method: Eighteen Wistar rats were anesthetized and submitted to colostomy; they were then distributed into two groups: Control Group, receiving intrarectal saline infusion (n = 8) and Group BD receiving intrarectal infusion ofBaccharis dracunculifolia extract (n = 10); after 21 days of treatment they were euthanized, the intestinal segment excluded from intestinal transit was resected and submitted to histopathological study, classifying the degree of inflammation and degree of vascular congestion from 0 to 3. Results: Mean inflammation was 2.7 in Control Group versus 2.1 in BD Group (p = 0.049), while mean vascular congestion was 2.3 and 2, respectively, in Control and BD groups (p = 0.1642). Conclusion: Intra-rectal infusion ofBaccharis dracunculifolia extract significantly minimized the inflammatory process in the exclusion colitis of rats submitted to colostomy, without altering the degree of vascular congestion.


Resumo Racional A colite de desuso é frequente em nosso meio e o tratamento de maior eficácia é de alto custo, havendo necessidade de se encontrar uma terapêutica eficaz e de baixo custo. Objetivo Avaliar a eficácia da Baccharis dracunculifolia (alecrim-do-campo) no tratamento da colite de exclusão em ratos. Método Utilizou-se 18 ratos Wistar, os quais foram anestesiados e submetidos à colostomia; em seguida distribuídos em 2 grupos: Grupo Controle, recebendo infusão intrarretal de solução salina (n = 8) e Grupo BD, recebendo infusão intrarretal de extrato de Baccharis dracunculifolia (n = 10); após 21 dias de tratamento foram submetidos a eutanásia, o segmento intesinal excluso de trânsito intestinal foi ressecado e submetido a estudo histopatológico classificando-se o grau de inflamação e grau de congestão vascular de 0 a 3. Resultados Verificou-se média de inflamação 2,7 no Grupo Controle vs. 2,1 no Grupo BD (p = 0,049), enquanto as médias de congestão vascular foram 2,3 e 2, respectivamente, nos grupos controle e BD (p = 0,1642). Conclusão A infusão intrarretal do extrato de Baccharis dracunculifolia minimizou significantemente o processo inflamatório na colite de exclusão de ratos submetidos à colostomia, sem alterar o grau de congestão vascular.


Subject(s)
Animals , Rats , Colitis , Colitis/drug therapy , Plant Preparations , Vernonia , Phytotherapy , Plants, Medicinal , Colostomy , Vernonia/adverse effects
3.
Recife; Fiocruz-PE; 2020. 350 p. il.
Monography in Portuguese | LILACS (Americas), MTYCI | ID: biblio-1102323

ABSTRACT

Pohã Ñana: Fortalecimento, território e memória Guarani e Kaiowá é resultado de um amplo processo de diálogo entre o grupo de pesquisa Ambiente, Diversidade e Saúde da Fundação Oswaldo Cruz (Fiocruz) e o povo Guarani e Kaiowá das aldeias Guapo'y (Amambai), Jaguapiré, Guasuty, Kurusu Amba, Tapyi Kora (Limão Verde) e Takuapery, localizadas na região conhecida como cone Sul, no estado de Mato Grosso do Sul (Mapa). Este livro foi elaborado como produto da pesquisa "Práticas tradicionais de cura e plantas medicinais mais prevalentes entre os indígenas da etnia Guarani e Kaiowá, na região Centro-Oeste" e teve como objetivo identificar e descrever as práticas tradicionais de cura e as plantas medicinais mais prevalentes entre os Guarani e Kaiowá. Com isso, nossa intenção é proporcionar aos leitores uma aproximação do conhecimento tradicional Guarani e Kaiowá, a partir dos relatos de experiências ancestrais de ñanderu e ñandesy com o uso de plantas medicinais. Ademais, pretendemos compartilhar com os leitores os aprendizados construídos de modo dialógico com os jovens das aldeias, que se tornaram posteriormente pesquisadores/colaboradores em nosso grupo de pesquisa.


Subject(s)
Plants, Medicinal , Indians, South American , Phytotherapy , Brazil , Indigenous Peoples , Medicine, Traditional
4.
Sci. med. (Porto Alegre, Online) ; 30(1): e-34860, 2020.
Article in English | LILACS (Americas) | ID: biblio-1087374

ABSTRACT

Aims: The objective of this study was to identify the phytochemical profile and to evaluate the biological effects of the crude ethanolic extract (EE) and the ethanolic fraction (EF) of leaves of the species Cissus spinosa Cambess, after oxidative stress induced by cyclophosphamide (CP) in mice. Methods: Phytochemical profile was performed detecting functional groups and, analysis of total flavonoids and phenols concentration, as well as the antiradical activity in EE and EF. The phytochemical characterization was done for the identification of flavonoids present in the leaves of the plant. In the biochemical tests, hematological parameters, glucose, total cholesterol, creatinine, alkaline phosphatase and aminotransferases dosages in plasma, enzymatic and non--enzymatic antioxidants and lipid damage marker were evaluated in different tissues (liver, kidney and heart), besides genotoxic and immunological analyzes. The animals received 15 days of treatment, via gavage, with EE (50 mg kg-1) or EF (50 mg kg-1) and on the 15th day, an intraperitoneal injection of CP (100 mg kg-1) or saline (0.9%). After 24 h the last treatment, the animals were anesthetized for blood withdrawal, sacrificed and removal of the organs. Results: In the phytochemical analyzes, the presence of alkaloids, flavonoids and phenols was identified, the latter presented a higher concentration for EF. Eight flavonoids were identified - Rutin, Quercetin-3-ß-D-glucoside, Quercitrin, Taxifolin, Quercetin, Canferol, Luteolin and Apigenin. In the biochemical analyzes, in general, EE showed a better antioxidant action against oxidative damages, hypoglycemic and antitilipemic action when comparing with EF, probably due to the synergism caused by flavonoids. It was observed the reduction and an increase of micronucleated polychromatic erythrocytes, due to the action of antioxidant compounds and alkaloids present in the plant, also considering the question of the seasonal period that directly interferes in the production of these compounds. In the immunological analysis, the extracts did not stimulate the spontaneous production of oxygen peroxide (H2 O2) and nitric oxide (NO•). Conclusions: Other studies, such as the variation of the chemical composition of the plant by local seasonality, hypoglycemic and antilipemic action, should be carried out to better delineate the biological action present in this plant.


Objetivos: O objetivo deste estudo foi identificar o perfil fitoquímico e avaliar os efeitos biológicos do extrato etanólico bruto (EE) e da fração etanólica (EF) das folhas da espécie Cissus spinosa Cambess, após estresse oxidativo induzido pela ciclofosfamida. (CP) em camundongos. Métodos: O perfil fitoquímico foi realizado detectando grupos funcionais e, análise da concentração de flavonoides e fenóis totais, bem como a atividade antirradical em EE e EF. A caracterização fitoquímica foi realizada para a identificação de flavonoides presentes nas folhas da planta. Nos testes bioquímicos, os parâmetros hematológicos, as dosagens de glicose, colesterol total, creatinina, fosfatase alcalina e aminotransferases no plasma, os antioxidantes enzimáticos e não enzimáticos e o marcador de dano lipídico foram avaliados em diferentes tecidos (fígado, rim e coração), além de análises genotóxicas e imunológicas. Os animais receberam 15 dias de tratamento, via gavagem, com EE (50 mg kg-1) ou EF (50 mg kg-1) e no 15º dia, injeção intraperitoneal de CP (100 mg kg-1) ou soro fisiológico (0,9%) . Após 24 h do último tratamento, os animais foram anestesiados para retirada do sangue, sacrificados e após a retirada dos órgãos. Resultados: Nas análises fitoquímicas, identificou-se a presença de alcaloides, flavonoides e fenóis, estes últimos apresentaram maior concentração para EF. Oito flavonoides foram identificados - rutina, quercetina-3-ß--D-glicosídeo, quercitrina, taxifolina, quercetina, canferol, luteolina e apigenina. Nas análises bioquímicas, em geral, o EE apresentou melhor ação antioxidante contra os danos oxidativos, ação hipoglicemiante e antitilipêmica quando comparada à EF, provavelmente devido ao sinergismo causado pelos flavonoides. Observou-se a redução e um aumento de eritrócitos policromáticos micronucleados, devido à ação de compostos antioxidantes e alcaloides presentes na planta, considerando também a questão do período sazonal que interfere diretamente na produção desses compostos. Na análise imunológica, os extratos não estimularam a produção espontânea de peróxido de oxigênio (H2O2) e óxido nítrico (NO•). Conclusões: Outros estudos, como a variação da composição química da planta por sazonalidade local, ação hipoglicemiante e antilipêmica, devem ser realizados para melhor delineamento da ação biológica presente nesta planta.


Subject(s)
Phytochemicals , Phytotherapy , Flavonoids , Oxidative Stress
5.
Rev. cuba. estomatol ; 56(4): e1779, oct.-dez. 2019.
Article in Spanish | LILACS (Americas) | ID: biblio-1093254

ABSTRACT

RESUMEN Introducción: El tratamiento de la enfermedad periodontal incluye la terapia mecánica, el cual se complementa con el uso de antibióticos/antisépticos, lo que podría plantear efectos adversos a largo plazo. Objetivo: Describir el potencial farmacológico del fruto de la M. dubia, y su aplicación como complemento en la terapia periodontal. Métodos: Se revisaron revistas internacionales de impacto de la Web of Science relacionadas con el tema (58 revistas). Se consultaron las bases de datos Google Académico, SciELO, PubMed y EBSCO, utilizando los descriptores: "review"; "phytotherapy"; "myrtaceae"; "gingivitis"; "periodontitis"; "periodontal diseases"; "anti-bacterial agents"; "anti-inflammatory agents"; "dental plaque"; "antioxidants"; "plants, toxic"; "adverse effects". Se obtuvo 517 artículos de los cuales 60 fueron incluidos en el estudio. El 91,7 por ciento de los artículos fueron de los últimos tres años. Integración de la información: Se expuso las propiedades y seguridad en humanos del uso de la M. dubia. Conclusiones: La M. dubia tiene actividad antimicrobiana in vitro frente a microorganismos de la biopelícula dental, siendo más sensibles el S. mutans, S. mitis y P. gingivalis al extracto hidroalcohólico de la semilla, y el S. aureus al extracto hidroalcohólico de las hojas y corteza. También se evidencia su actividad antiinflamatoria. Los hallazgos sugieren que el extracto etanólico de la M. dubia podría incorporarse en antisépticos de uso bucal, dado su potencial antibiopelícula y antiinflamatoria(AU)


ABSTRACT Introduction: Treatment of periodontal disease includes mechanical therapy complemented with antibiotics / antiseptics, which could lead to the occurrence of long-term adverse effects. Objective: Describe the pharmacological potential of the fruit of M. dubia and its use as adjunct in periodontal therapy. Methods: A review was conducted of international high impact journals from the Web of Sciences which dealt with the topic (58 journals). The databases Google Scholar, SciELO, PubMed and EBSCO were consulted, using the descriptors "review", "phytotherapy", "Myrtaceae", "gingivitis", "periodontitis", "periodontal diseases", anti-bacterial agents", "anti-inflammatory agents", "dental plaque", "antioxidants", "plants, toxic", "adverse effects". A total 517 papers were obtained, of which 60 were included in the study. 91.7 percent of the papers had been published in the last three years. Data integration: A description was provided of the properties and safety of the use of M. dubia in humans. Conclusions: M. dubia has in vitro antimicrobial activity against dental biofilm microorganisms, particularly S. mutans, S. mitis and P. gingivalis to the seed hydroalcoholic extract, and S. aureus to the leaf and peel hydroalcoholic extract. Anti-inflammatory activity was also observed. Results suggest that M. dubia ethanolic extract could be incorporated into oral antiseptics, given its antibiofilm and anti-inflammatory potential(AU)


Subject(s)
Humans , Periodontal Diseases/drug therapy , Review Literature as Topic , Myrtaceae/adverse effects , Phytotherapy/methods , Databases, Bibliographic
6.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 11(5): 1129-1134, out.-dez. 2019. ilus
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1021911

ABSTRACT

Objetivo: Identificar as plantas utilizadas com fins terapêuticos por usuários de uma unidade pré-hospitalar pública do município de Campos dos Goytacazes/RJ, os modos de preparo e uso, e o conhecimento deles sobre às propriedades terapêuticas, mecanismos de ação e indicação das plantas que utilizam. Métodos: Pesquisa descritiva, exploratória e qualitativa, operacionalizada por dez entrevistas semiestruturadas em abril de 2016, cujos dados foram tratados por análise temática. Resultados: Foram citadas 40 plantas, sendo a mais frequente a erva cidreira (Lippia alba), utilizada como calmante. A principal forma de obtenção das plantas é por meio de cultivo próprio; e o chá, preparado por infusão ou decocção, a principal forma de consumo. Foram citados malefícios associados ao uso da arnica (Solidago chilensis). Conclusão: Verificou-se que a maior parte das plantas utilizadas é de procedência regional, cujo conhecimento de uso foi adquirido por mães e avós


Objective: The study's purpose has been to identify the plants used for therapeutic purposes by users of a public pre-hospital unit in the Campos dos Goytacazes city, Rio de Janeiro State. Furthermore, to identify the methods of preparation and use, and their knowledge about the therapeutic properties, mechanisms of action and indication of the plants they use. Methods: It is a descriptive-exploratory research with a qualitative approach, which was performed through ten semi-structured interviews in April 2016, whose data were processed by thematic analysis. Results: 40 plants were mentioned, the most frequent being the lemongrass (Lippia alba) that was used as a soothing medicine; the main way of obtaining the plants is by means of own cultivation; and the tea, prepared by infusion or decoction, the main form of consumption. Unpleasant effects associated with the use of bush arnica (Solidago chilensis) were mentioned. Conclusion: It was verified that most of the plants used are of regional origin, whose knowledge of use was acquired through their relatives


Objetivo: Identificar las plantas utilizadas con fines terapéuticos por los usuarios de una unidad pública prehospitalaria en la ciudad de Campos dos Goytacazes/RJ, los métodos de preparación, uso y sus conocimientos sobre las propiedades terapéuticas, mecanismos de acción e indicación de las plantas. Método: Se desarrolló una investigación descriptiva, exploratoria y cualitativa, operada por diez entrevistas semiestructuradas en abril de 2016, cuyos datos fueron tratados por análisis temático. Resultados: Se mencionaron 40 plantas, siendo la más frecuente la hierba de limón (Lippia alba). La forma principal de obtención de las plantas es mediante el cultivo propio; y el té, preparado por infusión o decocción, la forma principal de consumo. Se citaron los efectos de la enfermedad asociados con el uso de arnica (Solidago chilensis). Conclusión: La mayoría de las plantas utilizadas son de origen regional, cuyo conocimiento de uso fue adquirido por familiares


Subject(s)
Humans , Plants, Medicinal , Complementary Therapies , Health Knowledge, Attitudes, Practice , Phytotherapy , Ethnobotany
8.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(2 (Supl)): 197-200, abr.-jun. 2019. ilus, tab
Article in Portuguese | LILACS (Americas) | ID: biblio-1009734

ABSTRACT

A doença aterosclerótica crônica (DAC) é uma condição bastante prevalente em nosso meio e uma das principais doenças cardiovasculares ligadas ao envelhecimento. Dentre as opções terapêuticas adjuvantes, o Picnogenol ®, extrato da casca do Pinus pinaster, tem sido alvo de estudo em decorrência de função antioxidante, anti-inflamatória e antiplaquetária. Este artigo é uma revisão narrativa, cujo objetivo é avaliar o uso do Picnogenol® como opção terapêutica da DAC. Os estudos incluídos foram pesquisados nas bases de dados: PubMed, Scielo, The Cochrane Library, Scopus e LILACS, sendo excluídos, considerando suas restrições para avaliação terapêutica, os relatos de caso e séries de caso com n ≤ 5. Como resultado, os estudos têm apontado vantagens do uso Picnogenol® no tratamento da DAC, assim como de outras doenças cardiovasculares, porém, o número de pesquisas ainda é pequeno (principalmente ensaios clínicos) e há importantes limitações de tamanho amostral, o que dificulta sua atual recomendação na prática clínica


Chronic atherosclerosis is a highly prevalent condition and one of the main cardiovascular diseases linked to the aging process. Among the adjuvant therapeutic options, Pycnogenol® (Pinus pinaster bark extract) has been studied because of its antioxidant, anti-inflammatory and antiplatelet functions. This article is a narrative review aimed at evaluating the use of Pycnogenol® as a therapeutic option in the treatment of chronic atherosclerosis. The studies included were obtained from the following databases: PubMed, Scielo, The Cochrane Library, Scopus and LILACS. Case reports and case series with n≤5 were excluded due to their restrictions for therapeutic evaluation. As a result, the studies have indicated advantages in the use of Pycnogenol® in the treatment of chronic atherosclerosis as well as other cardiovascular diseases. However, the number of studies is still small (particularly clinical trials), and there are important sample size limitations, which restricts its current recommendation in clinical practice


Subject(s)
Humans , Male , Female , Pinus , Atherosclerosis/physiopathology , Aging , Cardiovascular Diseases/mortality , Chronic Disease , Risk Factors , Diabetes Mellitus , Heart Diseases , Hypertension , Phytotherapy/methods , Antioxidants
9.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-771524

ABSTRACT

At present,Western medicine is widely used in the treatment of epilepsy.However,about 30%-40% of epileptic patients are resistant to them and are affected by the side effects of these drugs.Traditional Chinese medicine is effective in treating epileptic seizures and relieving complications caused by Western medicine.However,the active ingredients and mechanisms of traditional Chinese medicine remain unclear.This article reviews and summarizes the advances and mechanisms in treating epilepsy,such as Chinese medicine monomer,the extracts of single Chinese medicine and Chinese medicine compound.Chinese medicine monomers,including gastrodin,asarone,rhynchophylline,ligustrazine,tanshinone ⅡA,curcumin,etc.,have antiepileptic effects via regulating excitatory neurotransmitters and receptors,the expression of inflammatory factors,sodium/potassium ion channels and the expression of apoptotic protein,therefore protecting neurons.The extracts of single Chinese herbal including the extracts of Gastrodiae Rhizoma,Acori Tatarinowii Rhizoma,Ginseng Radix et Rhizoma,Ganoderma,Scutellariae Radix and Ginkgo Folium,etc.,have antiepileptic effects related to the inhibition of γ-aminobutyric acid receptor,upregulation of phosphatidylinositol 3-kinase signaling pathway and reduction of glutamate-induced excitotoxicity and oxidative stress response.Furthermore,these extracts can regulate ion channels and reduce oxidative damage of neurons.Chinese medicine compounds including Dianxian Qing Granules,Danxing Ningxian Granules,Huoxue Dingxian formulae,etc.,can improve the therapeutic effect on epilepsy through simultaneously regulating excitatory transmitters,apoptosis factors and cytokines.


Subject(s)
Drugs, Chinese Herbal , Epilepsy , Drug Therapy , Humans , Medicine, Chinese Traditional , Phytotherapy
10.
Article in English | WPRIM (Western Pacific) | ID: wprim-719624

ABSTRACT

PURPOSE: Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few contraindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204, Korean herbal formula) improved LOH. KH-204 is a strong antioxidant herbal formula. We evaluated the effect of Korean herbal prescription on androgen receptor (AR) expression in an aged rat model of LOH. MATERIALS AND METHODS: Eighteen-month-old rats were used as aged LOH rat models. Eighteen Sprague-Dawley rats were randomly divided into three equal groups of six animals each and treated with one of the following: 1) normal control group (oral administration with distilled water, n=6), 2) KH-204 200 group (oral administration with 200 mg/kg of KH-204, n=6), and 3) KH-204 400 group (oral administration with 400 mg/kg of KH-204, n=6). After four weeks of treatment (once daily, distilled water or KH-204), serum testosterone levels, changes in testicular and epididymal weight, Western blotting analysis of AR expression and measurement of oxidative stress were examined. RESULTS: Treatment with the herbal formulation KH-204 200 mg/kg and 400 mg/kg (1) increased the weights of testis and epididymis; (2) increased the level of serum testosterone; (3) increased the level of superoxide dismutase and reduced the level of 8-hydroxy-20-deoxyguanosine; and (4) upregulated AR expression in testicular tissue. CONCLUSIONS: KH-204 might be an effective alternative for LOH. It improves antioxidant mechanisms and increases testicular AR expression without side-effects.


Subject(s)
Aging , Animals , Blotting, Western , Epididymis , Hypogonadism , Male , Models, Animal , Oxidative Stress , Phytotherapy , Prescriptions , Rats , Rats, Sprague-Dawley , Receptors, Androgen , Superoxide Dismutase , Testis , Testosterone , Water , Weights and Measures
11.
Ambato; s.n; 2019. 1-54 p. ilus, tab, graf.
Thesis in Spanish | LILACS (Americas), MTYCI | ID: biblio-998009

ABSTRACT

La mayor parte de la población mundial hace uso de la medicina herbolaria como remedio para múltiples patologías ya sea por tradición cultural o porque no existen otras opciones terapéuticas en base a ello, se desarrolló el presente proyecto investigativo con el objetivo de analizar el uso de plantas medicinales como efecto analgésico-antiinflamatorio en el Cantón Palora. Para ello, se utilizó una metodología cuali-cuantitativa, documental, descriptiva y de temporalidad transversal que involucró a 322 personas del cantón Palora. de las comunidades de: Chinimpe, Panquisha, San Luis, Shiram, Las Palmas. Como técnicas de recolección de datos se empleó la encuesta, misma que fue aplicada para conocer la predilección tanto del tratamiento convencional como alternativo que tienen los pobladores ante ciertas patologías y las razones para su consumo. A través del estudio se pudo concluir que el cantón Palora tiene acceso limitado a servicios de salud de primer nivel por lo que los tratamientos convencionales son poco utilizados en la comunidad y tomando en cuenta que la vegetación es abundante y biodiversa es común que sus habitantes opten por utilizar mayoritariamente plantas medicinales con efectos analgésicos y antiinflamatorios para múltiples patologías pues este este tipo de medicina ha demostrado ser efectivas en el restablecimiento y cuidado de la salud. (AU)


Subject(s)
Humans , Plants, Medicinal , Rural Population , Analgesics , Anti-Inflammatory Agents , Ecuador , Phytotherapy , Medicine, Traditional
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-776895

ABSTRACT

Chimonanthus plants widely distributed in southern area of China, which have a long history of edibles and medicine. Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents, including alkaloids, flavonoids, terpenoids, coumarins and others, which exhibit significant anti-oxidant, anti-bacterial, anti-cancer, anti-inflammatory, antihyperglycemic, antihyperlipidemic and other biological activities. On the basis of systematic reviewing of literatures, this article overviews the non-volatile constituents and pharmacology of Chimonanthus from domestic and foreign over the last 30 years (until June 2018), and may provide a useful reference for the further development of Chimonanthus.


Subject(s)
Animals , Calycanthaceae , Chemistry , Drugs, Chinese Herbal , Chemistry , Pharmacology , Toxicity , Humans , Medicine, Chinese Traditional , Phytochemicals , Chemistry , Pharmacology , Toxicity , Phytotherapy
13.
Article in English | WPRIM (Western Pacific) | ID: wprim-776867

ABSTRACT

In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized (OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography (Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry (GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.


Subject(s)
Animals , Cimicifuga , Chemistry , Classification , Dietary Supplements , Drug Evaluation, Preclinical , Female , Humans , Menopause , Blood , Metabolomics , Osteoporosis , Blood , Drug Therapy , Ovariectomy , Phytotherapy , Plant Extracts , Blood , Rats , Rats, Sprague-Dawley
14.
Article in English | WPRIM (Western Pacific) | ID: wprim-773394

ABSTRACT

OBJECTIVE@#Age-related diseases, including neurodegenerative diseases, are associated with oxidative stress and lipid peroxidation, and increase the levels of cholesterol auto-oxidation products such as 7β-hydroxycholesterol (7β-OHC). Thus, it is imperative to identify agents that can prevent 7β-OHC-induced side-effects.@*METHODS@#We evaluated the potential protective effects of Carpobrotus edulis ethanol-water extract (EWe) on murine oligodendrocytes (158N) cultured in the absence or presence of 7β-OHC (20 μg/mL, 24 h). The cells were incubated with EWe (20-200 µg/mL) 2 h before 7β-OHC treatment. Mitochondrial activity and cell growth were evaluated with the MTT assay. Photometric methods were used to analyze antioxidant enzyme [catalase (CAT) and glutathione peroxidase (GPx)] activities and the generation of lipid and protein oxidation products [malondialdehyde (MDA), conjugated diene (CD), and carbonylated proteins (CPs)].@*RESULTS@#Treatment with 7β-OHC induced cell death and oxidative stress (reflected by alteration in CAT and SOD activities). Overproduction of lipid peroxidation products (MDA and CDs) and CPs was also reported. The cytotoxic effects associated with 7β-OHC were attenuated by 160 μg/mL of EWe of C. edulis. Cell death induced by 7β-OHC treatment was ameliorated, GPx and CAT activities were restored to normal, and MDA, CD, and CP levels were reduced following C. edulis extract treatment.@*CONCLUSION@#These data demonstrate the protective activities of C. edulis EWe against 7β-OHC-induced disequilibrium in the redox status of 158N cells, indicative of the potential role of this plant extract in the prevention of neurodegenerative diseases.


Subject(s)
Aizoaceae , Animals , Cell Line , Drug Evaluation, Preclinical , Hydroxycholesterols , Mice , Neurodegenerative Diseases , Neuroprotection , Oligodendroglia , Metabolism , Oxidative Stress , Phytotherapy , Plant Extracts , Pharmacology
15.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-774586

ABSTRACT

The clinical efficacy of Bushen Huoxue traditional Chinese medicine( TCM) in the treatment of hyperprolactinemia were systematically evaluated,which provided evidence-based medical evidence for the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine. The randomized controlled trials on the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine were comprehensively searched by computer in PubMed,EMbase,Cochrane Library,CNKI,Wan Fang,VIP,CBM and Meta-analysis was performed. The search time is from the time of self-built database to September 28,2018. A total of 816 patients with hyperprolactinemia met the inclusion criteria in 13 clinical studies. The results of Meta-analysis showed that compared with Western medicines,traditional Chinese medicine for tonifying kidney and activating blood circulation had a comparable effect in reducing prolactin and treating infertility,and had obvious advantages in improving of TCM syndromes,disease recurrence and reducing of side effects.


Subject(s)
Drugs, Chinese Herbal , Female , Herbal Medicine , Humans , Hyperprolactinemia , Drug Therapy , Phytotherapy
16.
Edumecentro ; 10(4): 139-149, oct.-dic. 2018. ilus
Article in Spanish | LILACS (Americas) | ID: biblio-975077

ABSTRACT

Fundamento: la homeopatía es una ciencia que atiende al paciente con un enfoque holístico; ha demostrado su validez en el tratamiento exitoso de determinadas dolencias. Objetivo: elaborar una miniguía como recurso de apoyo al médico homeópata para el tratamiento de la hipertensión arterial. Métodos: se realizó una investigación observacional transversal en la Universidad de Ciencias Médicas de Villa Clara, durante el año 2016. Se emplearon métodos teóricos: histórico-lógico, analítico-sintético, inductivo-deductivo y sistémico-estructural; y empíricos: la encuesta en forma de cuestionario a los médicos diplomados en homeopatía para comprobar su nivel de conocimientos sobre el tema. Resultados: los autores consideran que la literatura sobre homeopatía resulta aún insuficiente, se evidenciaron carencias de conocimientos entre los profesionales encuestados y desactualización bibliográfica en los contenidos, por lo que se elaboró una miniguía homeopática que fue valorada por criterios de especialistas. Conclusiones: contiene la descripción de múltiples medicamentos homeopáticos para combatir la hipertensión arterial y fue valorada como útil, pertinente, factible, actualizada en sus contenidos y de valor científico-pedagógico por los especialistas consultados.


Background: homeopathy is a science that cares for the patient with a holistic approach; it has proven its validity in the successful treatment of certain ailments. Objective: to elaborate a mini-guide as a support resource for the homeopathic doctor for the treatment of high blood pressure. Methods: a cross-sectional observational research was carried out at Villa Clara University of Medical Sciences, during 2016. Theoretical methods were used: historical-logical, analytical-synthetic, inductive-deductive and systemic-structural; and empirical ones: the survey in the form of a questionnaire to doctors qualified in homeopathy to check their level of knowledge on the subject. Results: the authors consider that the literature on homeopathy is still insufficient, there was a lack of knowledge among the professionals surveyed and bibliographic outdating in content, so a homeopathic mini-guide was developed that was assessed by specialists. Conclusions: it contains the description of multiple homeopathic medicines to face high blood pressure and was assessed as useful, pertinent, feasible, updated in its contents and of scientific-pedagogical value by the specialists consulted.


Subject(s)
Homeopathy Broadcasting , Education, Medical , Homeopathy , Phytotherapy , Medicine, Traditional
17.
J. bras. nefrol ; 40(4): 312-318, Out.-Dec. 2018. graf
Article in English | LILACS (Americas) | ID: biblio-984585

ABSTRACT

ABSTRACT Introduction: Ischemia and reperfusion (IR) is a process inherent to the procedures involved in the transplantation of organs that causes inflammation, cell death and cell injury, and may lead to rejection of the graft. It is possible that the anti-inflammatory properties of the Brazil nuts (BN) can mitigate the renal injury caused by IR. Objective: To investigate whether the previous intake of BN reduces the expression of markers of inflammation, injury, and cell death after renal IR. Methods: Male Wistar rats were distributed into six groups (N = 6/group): SHAM (control), SHAM treated with 75 or 150 mg of BN, IR, and IR treated with 75 or 150 mg of BN. The IR procedure consisted of right nephrectomy and occlusion of the left renal artery with a non-traumatic vascular clamp for 30 min. BN was given daily from day 1 to 7 before surgery (SHAM or IR), and maintained until sacrifice (48 h after surgery). Inflammation was evaluated by renal expression of COX-2 and TGF-β, injury by the expression of vimentin, and cell death by apoptosis through caspase-3 expression (immunohistochemistry). Results: Pretreatment with 75 mg of BN reduced renal expression of the COX-2, TGF-β, vimentin, and caspase-3. The dose of 150 mg caused increased expression of COX-2. Conclusion: In experimental IR, the damage can be minimized with a prior low-dose intake of BN, improving inflammation, injury, and cell death.


RESUMO Introdução: Isquemia e reperfusão (IR) é um processo inerente aos procedimentos envolvidos no transplante de órgãos, que causa inflamação, morte celular e lesão, podendo levar à rejeição do enxerto. É possível que a castanha-do-brasil (CB), por suas propriedades anti-inflamatórias, possa atenuar a lesão renal causada pela IR. Objetivo: Investigar se a ingestão prévia de CB reduz a expressão de marcadores renais de inflamação, lesão e morte celular após a IR. Métodos: Ratos Wistar machos foram distribuídos em seis grupos (N = 6/grupo): SHAM (controle), SHAM tratado com 75 ou 150 mg de CB, IR, e IR tratado com 75 ou 150 mg de CB. O procedimento de IR consistiu na nefrectomia à direita e oclusão da artéria renal esquerda por 30 minutos. A castanha foi administrada diariamente por sete dias antes da cirurgia (SHAM ou IR), e mantida até o sacrifício (48 horas pós-cirurgia). A inflamação foi avaliada pela expressão renal de COX-2 e TGF-β; a lesão pela expressão de vimentina, e a morte celular por apoptose pela expressão de caspase-3, por imuno-histoquímica. Resultados: O pré-tratamento com 75 mg de CB reduziu a expressão renal de COX-2, de TGF-β, de vimentina e de caspase-3. A dose de 150 mg causou elevação da expressão de COX-2. Conclusão: No modelo experimental de IR renal, os danos podem ser minimizados com a ingestão prévia de baixas doses de CB, melhorando a inflamação, a lesão e a morte celular.


Subject(s)
Animals , Male , Rats , Bertholletia , Acute Kidney Injury/prevention & control , Phytotherapy , Nephritis/prevention & control , Reperfusion Injury/complications , Rats, Wistar , Acute Kidney Injury/etiology , Kidney/blood supply , Nephritis/etiology
18.
J. coloproctol. (Rio J., Impr.) ; 38(4): 283-289, Oct.-Dec. 2018. tab, ilus
Article in English | LILACS (Americas) | ID: biblio-975973

ABSTRACT

ABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton.


RESUMO Racional: Há necessidade de um tratamento de baixo custo para as fístulas anais complexas que possa curar sem causar incontinência fecal, havendo espaço para o estudo de fitoterápicos. Objetivo: Avaliar o efeito do extrato glicerinado de Aloe barbadensis Miller no tratamento de fístula anal em ratos. Método: Utilizou-se 30 ratos Wistar, submetidos à anestesia peritoneal com Cetamina e Xilasina, seguida de transfixação do esfíncter anal com fio de aço, que permaneceu por 30 dias para desenvolvimento da fístula anal. Após este período, o fio de aço foi removido e foram formados três grupos com 10 animais: A (controle), sem tratamento; B (sedenho), em que foi introduzido sedenho de algodão; C (sedenho terapêutico), em que foi introduzido fio de algodão como sedenho, e diariamente foi gotejado no sedenho extrato de Aloe barbadensis Miller; após 30 dias os sedentos dos Grupos B e C foram removidos, e, após duas semanas sem sedenho foi praticada a eutanásia e remoção dos espécimes, analisando-se fechamento da fístula e processo inflamatório. Resultados: Houve persistência da fístula em todos os animais do Grupo A, em seis do Grupo B e três do Grupo C (p = 0,015). As médias do grau de inflamação local foram 0,9 no Grupo A; 0,8 no Grupo B e 0 no Grupo C (p = 0,015). Conclusão: O uso de sedenho embebido em extrato glicerinado de Aloe barbadensis Miller foi efetivo na cicatrização de fístulas anais em ratos, além de ter causado menor processo inflamatório que o sedenho sem fitoterápico.


Subject(s)
Animals , Rats , Rectal Fistula , Aloe , Fecal Incontinence , Phytotherapy , Plants, Medicinal , Plant Extracts
19.
Bol. latinoam. Caribe plantas med. aromát ; 17(6): 583-603, nov. 2018. mapas, tab
Article in English | LILACS (Americas) | ID: biblio-1007363

ABSTRACT

Ethnobotanical studies focusing on the documentation of folk therapies employed for pneumonia are almost non-existence in Africa and elsewhere. Data on plants used to treat this ailments was obtained through informed consent semi-structured face-to-face interview and field observations with 128 conveniently selected Bapedi traditional healers (THs) residing in the Limpopo Province, South Africa. A total of 57 plant species distributed across 54 genera and 32 botanical families, mostly the Asteraceae (21.8%) and Fabaceae (18.7%) were used by THs to treat pneumonia and related symptoms. Therapeutic uses of larger number of the documented species are not recorded elsewhere in literature as treatments of these ailments. Overall, the most widely used species by all interviewed THs were Acacia erioloba, Clerodendrum ternatum, Cryptocarya transvaalensis, Enicostema axillare, Lasiosiphon caffer and Stylochaeton natalensis. Ethnopharmacological studies validating the reported therapeutic claims of the species by Bapedi THs should be a subject of future investigation.


Los estudios etnobotánicos que se centran en la documentación de las terapias populares empleadas para la neumonía son casi inexistentes en África y en otros lugares. Los datos sobre plantas utilizadas para tratar estas dolencias se obtuvieron a través de entrevistas personales semiestructuradas con consentimiento informado y observaciones de campo a 128 curanderos tradicionales (TH) convenientemente seleccionados que residen en la provincia de Limpopo, Sudáfrica. Las TH utilizaron un total de 57 especies de plantas distribuidas en 54 géneros y 32 familias botánicas, en su mayoría Asteraceae (21.8%) y Fabaceae (18.7%) para tratar la neumonía y los síntomas relacionados. Los usos terapéuticos de un gran número de las especies documentadas no se registran en ninguna otra parte de la literatura como tratamientos para estas dolencias. En general, las especies más utilizadas por todos los TH entrevistados fueron Acacia erioloba, Clerodendrum ternatum, Cryptocarya transvaalensis, Enicostema axillare, Lasiosiphon caffer y Stylochaeton natalensis. Los estudios etnofarmacológicos que validan las afirmaciones terapéuticas informadas de las especies por parte de Bapedi TH deben ser un tema de investigación futura.


Subject(s)
Humans , Plants, Medicinal/classification , Pneumonia/drug therapy , Plant Extracts/therapeutic use , Ethnobotany , South Africa , Health Knowledge, Attitudes, Practice , Surveys and Questionnaires , Medicine, African Traditional , Phytotherapy
20.
Bol. latinoam. Caribe plantas med. aromát ; 17(5): 453-491, sept. 2018. graf, tab
Article in English | LILACS (Americas) | ID: biblio-915688

ABSTRACT

Medicinal and aromatic plants are biologically and economically valuable species because of their intrinsic value as plants, ability to produce secondary metabolites, possible use in the pharmaceutical and food industries, germplasm availability and applications in traditional medicine. In addition, they hold social and economic importance due to the ancestral knowledge they represent and because they are part of the livelihood of many families. Most of them are collected from the wild and are in serious danger of extinction. Through biotechnological tools it is possible to develop their germplasm and obtain new and improved varieties from wild material, while advocating the alternative of production by cultivation instead of extracting it from nature. The objective of this review is to provide an updated perspective on the traditional uses, conservation status and biotechnological advances in a group of 30 plant species native to the American continent.


Las plantas medicinales y aromáticas deben ser valoradas tanto por su valor intrínseco como tales, por su capacidad de producir metabolitos secundarios, su posible uso en las industrias farmacéutica y alimentaria y por sus aplicaciones en medicina tradicional. Además, tienen importancia social y económica debido al conocimiento ancestral que representan y porque son parte del sustento de muchas familias. La mayoría de estas especies son recolectadas de la naturaleza y están en grave peligro de extinción. A través de herramientas biotecnológicas es posible desarrollar su germoplasma y obtener variedades nuevas y mejoradas a partir de material silvestre; esta estrategia propicia la alternativa de producción por cultivo en lugar de extraerla de la naturaleza. El objetivo de esta revisión es proporcionar una perspectiva actualizada de los usos tradicionales, el estado de conservación y los avances biotecnológicos en un grupo de 30 especies de plantas nativas del continente americano.


Subject(s)
Plants, Medicinal , Biotechnology , Phytotherapy/statistics & numerical data , Medicine, Traditional , Pharmacognosy , Americas , Natural Resources Exploitation , Conservation of Natural Resources
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