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Braz. j. biol ; 84: e255529, 2024. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1364534


Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.

Relatos da medicina popular costumam atuar como referencial para o desenvolvimento de novos fármacos a partir de moléculas naturais com ações terapêuticas para doenças de alta gravidade e prevalência como o câncer. Bromelia antiacantha Bertol. é uma espécie da família Bromeliaceae, considerada uma planta alimentícia não convencional (PANC), encontrada nas regiões sul e centro-oeste do Brasil. Apesar do alto teor nutritivo e potencial farmacológico de seus frutos, poucos estudos científicos relatam suas ações biológicas. Desta forma, este estudo avalia o perfil fitoquímico de extratos aquoso e etanólico obtidos de frutos de B. antiacantha, bem como a sua possível ação antioxidante, antitumoral e citotóxica. O extrato aquoso apresentou compostos fenólicos e flavonoides, enquanto os extratos etanólicos apontam a presença de flavonóides e cumarina em sua composição, independente da região de coleta. O extrato etanólico demonstrou efeito antioxidante mais promissor do que o extrato aquoso e também induziu uma inibição significativa na viabilidade de células humanas de câncer cervical da linhagem SiHa. Além disso, o tratamento com ambos extratos não alterou a viabilidade de células não tumorais da linhagem de queratinócitos humanos imortalizados (HaCaT). Estes dados trazem novas informações sobre extratos obtidos de uma espécie vegetal nativa, comestível e já utilizada tradicionalmente, mas abrindo novas perspectivas quanto a possíveis aplicações terapêuticas.

Flavonoids , Uterine Cervical Neoplasms , Bromeliaceae , Bromelia , Therapeutic Uses , Phytochemicals , Phytotherapy
Braz. j. biol ; 84: e255120, 2024. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1364532


This study aimed to determine the antiulcerogenic and antioxidant activities of Psyllium (Plantago ovata Forssk) seed ethanolic extract in rats. We assessed the antioxidant potential using free radical scavenging on DPPH, ß-carotene bleaching activity, ferric reducing power, and hydroxyl radical scavenging activity. In the antiulcerogenic study, pre-treatment with Plantago ovata seeds ethanolic extract (POE) (400 mg/kg b.wt) significantly protected against ethanol-induced gastric ulcer in rats by decreasing the ulcer index value and preserving the integrity of the gastric mucosa. The oxidative stress status in the stomach tissues showed a significant increase in the antioxidant enzyme levels of superoxide dismutase, catalase, and glutathione peroxidase with a significant decrease in lipid peroxidation during pre-treatment with POE. In conclusion, the POE protects against gastric ulcer due to its antioxidant potential and presence of bioactive molecules.

O presente estudo teve como objetivo determinar as atividades antiulcerogênica e antioxidante das sementes de Psyllium (Plantago ovata Forssk) em ratos. O potencial antioxidante foi avaliado utilizando o método do sequestro do radical livre DPPH, autooxidação do ß-caroteno, poder redutor de ferro e atividade de sequestro do radical hidroxila. No estudo antiulcerogênico, o pré-tratamento com o extrato etanólico das sementes de Plantago ovata (POE) (400 mg/Kg b.wt) reduziu a úlcera gástrica induzida pelo etanol em ratos, diminuindo o valor do índice de úlcera e preservando a integridade da mucosa gástrica. O estudo do estresse oxidativo nos tecidos estomacais mostrou um aumento significativo dos níveis das enzimas antioxidantes superóxido dismutase, catalase e glutationa peroxidase, com uma diminuição significativa da peroxidação lipídica enquanto pré-tratamento com POE. Em conclusão, o POE protege contra úlcera gástrica devido aos seus potenciais antioxidantes e à presença de moléculas bioativas.

Rats , Plantago , Stomach Ulcer , Gastric Mucosa , Phytotherapy , Antioxidants
Braz. j. biol ; 84: e250256, 2024. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1355912


Abstract Ferns are often used by indigenous people in Khyber Pakhtunkhwa, Pakistan. This study was designed to collect the ethnomedicinal and traditional knowledge of these locals about this group of vascular plants. Forty taxa belong to nineteen genera and ten families are used in the treatment of different diseases. The Pteridaceae was the most representative family with twelve taxa (30%), followed by Athyriaceae and Dryopteridaceae with six taxa each (30%), and Thelypteridaceae with five taxa (12.5%). Regarding the genera, Adiantum, Asplenium and Dryopteris ranked first with four taxa each (30%), followed by Aleuritopteris, Diplazium, Pteris and Equisetum with three taxa each (30%), followed by Athyrium, Oeosporangium, Polystichum and Pseudophegopteris with two taxa each (20%). These taxa were commonly used in the treatment of respiratory disorders i.e. asthma, bronchitis, emphysema, pneumonia; intestinal ulcer, stomach, urinary ailments and skin disorders by the methods of decoction and infusion. Traditional knowledge about ethnomedicinal plants is a valuable and essential source for the discovery of allopathic, herbal and homeopathic medicines.

Resumo As samambaias são frequentemente usadas pelos indígenas em Khyber Pakhtunkhwa, Paquistão. Este estudo foi desenhado para coletar o conhecimento etnomedicinal e tradicional desses moradores sobre este grupo de plantas vasculares. Quarenta táxons pertencem a dezenove gêneros, e dez famílias são utilizadas no tratamento de diferentes doenças. Pteridaceae foi a família mais representativa com doze táxons (30%), seguida por Athyriaceae e Dryopteridaceae com seis táxons cada (30%), e Thelypteridaceae com cinco táxons (12,5%). Em relação aos gêneros, Adiantum, Asplenium e Dryopteris ficaram em primeiro lugar com quatro táxons cada (30%), seguidos por Aleuritopteris, Diplazium, Pteris e Equisetum com três táxons cada (30%), e Athyrium, Oeosporangium, Polystichum e Pseudophegopteris com dois táxons cada (20%). Estes táxons foram comumente usados ​​no tratamento de distúrbios respiratórios, isto é, asma, bronquite, enfisema, pneumonia; úlcera intestinal, estômago, doenças urinárias e doenças da pele pelos métodos de decocção e infusão. O conhecimento tradicional sobre plantas etnomedicinais é uma fonte valiosa e essencial para a descoberta de medicamentos alopáticos, fitoterápicos e homeopáticos.

Humans , Plants, Medicinal , Ferns , Tracheophyta , Pakistan , Phytotherapy , Medicine, Traditional
Braz. j. biol ; 83: e246803, 2023. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1339417


Abstract Traditional medicine is cheaper and easily available to local people, to care for most frequent diseases in the Northern parts of Pakistan. Our study aimed at inventorying medicine from local plants, documenting their uses, and assessing their market value in 2015-2018 during spring, summer, and winter seasons. A total of 15 trips were made, 5 in each season. Semi-structured interviews with 165 inhabitant's age range between 20-80 years were conducted, analyzed the data is analyzed using Relative frequency of citation(RFC), Use Value(UV), Fidelity Level(FL), Informants consensus factor(ICF), and Jaccard index(JI) to find the most frequent and well-known used species in the area. A total of 86 species belonging to 39 vascular plant families, 33 genera were documented as medicinally important. Family Asteraceae was observed as the dominant family among all the families with 10 species, the leaf was the most used parts and decoction 36% was the most preferred preparation type. Herb was the predominant life form (67%). The maximum UV (0.92) was demonstrated by J. adhatoda L. species, while A. sativum L. shows maximum RFC (0.58), the highest ICF value represented by diarrhea and dermatitis 0.92, and high FL value is recorded 100%. According to our collections, wild species were 45%, invasive species were 38% and cultivated 17% recorded, dicots species were recorded more 81%. Seven 7 medicinal species is being economically important and export to the local and international market of the world, whereas P. integrima L. species were the most exported species according to the local dealers. The investigated area is rural and the local people depend on the area's plants for their health needs, and other uses like a vegetable, fuelwood, fodder, etc. The current result of RFC, UV, ICF, FL, and JI shows that medicinal flora needs to be pharmacologically and phytochemically investigated to prove their efficacy. The documentation of medicinal knowledge is important to preserve this precious old knowledge before it is lost forever, due to technological and environmental changes in the world.

Resumo A medicina tradicional é mais barata e facilmente disponível à população local para cuidar das doenças mais frequentes nas áreas do norte do Paquistão. Nosso estudo teve como objetivo inventariar medicamentos de plantas locais, documentar seus usos e avaliar seu valor de mercado em 2015-2018 durante as temporadas de primavera, verão e inverno. Foram feitas 15 viagens, 5 em cada temporada. Foram realizadas entrevistas semiestruturadas com 165 moradores na faixa etária de 20 a 80 anos, com dados analisados ​​por meio de frequência relativa de citação (RFC), valor de uso (UV), nível de fidelidade (FL), fator de consenso de informantes (CIF), e o índice de Jaccard (JI) para encontrar as espécies utilizadas mais frequentes e conhecidas na área. Um total de 86 espécies pertencentes a 39 famílias de plantas vasculares, 33 gêneros foram documentados como medicamente importantes. A família Asteraceae foi observada como a família dominante entre todas as famílias com 10 espécies, a folha foi a parte mais utilizada e a decocção 36% foi o tipo de preparação mais preferido. A erva foi a forma de vida predominante (67%). O UV máximo (0,92) foi demonstrado pelas espécies de J. adhatoda L., enquanto A. sativum L. mostra RFC máximo (0,58), o maior valor de ICF representado por diarreia e dermatite 0,92, e alto valor de FL é registrado 100%. De acordo com nossas coleções, as espécies selvagens foram 45%, as espécies invasoras 38% e as cultivadas 17% registradas, as espécies dicotiledôneas foram registradas mais 81%. Sete espécies medicinais estão sendo economicamente importantes e exportadas para o mercado local e internacional do mundo, enquanto as espécies de P. integrima L. foram as espécies mais exportadas de acordo com os comerciantes locais. A área investigada é rural e a população local depende das plantas da área para suas necessidades de saúde e outros usos como vegetal, lenha, forragem etc. O resultado atual de RFC, UV, ICF, FL e JI mostra que a flora medicinal precisa ser investigada farmacológica e fitoquimicamente para comprovar sua eficácia. A documentação do conhecimento medicinal é importante para preservar esse precioso conhecimento antigo antes que se perca para sempre, devido às mudanças tecnológicas e ambientais do mundo.

Humans , Middle Aged , Aged , Aged, 80 and over , Young Adult , Plants, Medicinal , Pakistan , Surveys and Questionnaires , Plant Leaves , Ethnobotany , Phytotherapy , Medicine, Traditional
Arq. ciências saúde UNIPAR ; 26(3): 892-900, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399500


As Práticas Integrativas e Complementares (PICs) apresentam-se como métodos coadjuvantes, auxiliando na obtenção de sucesso em determinados tratamentos clínicos e/ou cirúrgicos, atuando na prevenção, auxiliando na cura e no equilíbrio psicossomático com a finalidade de reestabelecer concordância entre mente e corpo. O Conselho Federal de Odontologia (CFO) regulamentou práticas como acupuntura, hipnose, terapia floral e fitoterapia, entretanto, suas aplicabilidades dependem da emissão de uma habilitação e seu devido registro no Conselho (Resolução CFO 82/2008). Para a Odontologia, as PICs proporcionam novas ferramentas para exercer um atendimento integral do ser humano. Neste trabalho, propõe-se fazer uma revisão de literatura sobre as PICs e Odontologia. Esta revisão de literatura foi realizada por meio de busca de artigos na base de dados Scielo, PubMed e Scholar Google no período de 2000 a 2021. Foram encontrados artigos sobre as seguintes PICs atuando conjuntamente com a Odontologia: terapias florais, acupuntura, hipnodontia, ozonioterapia, laserterapia, fitoterapia, homeopatia e odontologia antroposófica. Essas práticas apresentam grande valia, pois promovem o bem-estar sem causar dano ao indivíduo, apresentando poucos ou nenhum efeito colateral possibilitando maior segurança aos pacientes, além de favorecer a relação entre paciente e cirurgião-dentista, otimizando o tempo de trabalho no consultório odontológico e reduzindo custos.

Integrative and Complementary Practices (PICs) are presented as supporting methods, helping to achieve success in certain clinical and/or surgical treatments, acting in prevention, assisting in healing and psychosomatic balance in order to reestablish agreement between mind and body. . The Federal Council of Dentistry (CFO) has regulated practices such as acupuncture, hypnosis, floral therapy and herbal medicine, however, their applicability depends on the issuance of a license and its proper registration with the Council (Resolution CFO 82/2008). For Dentistry, PICs provide new tools to provide comprehensive care to human beings. In this work, we propose to review the literature on PICs and Dentistry. This literature review was carried out by searching articles in the Scielo, PubMed and Scholar Google databases from 2000 to 2021. Articles were found on the following PICs working together with Dentistry: floral therapies, acupuncture, hypnodontics, ozone therapy , laser therapy, phytotherapy, homeopathy and anthroposophic dentistry. These practices are of great value, as they promote well-being without causing harm to the individual, presenting few or no side effects, allowing greater safety for patients, in addition to favoring the relationship between patient and dentist, optimizing working time in the dental office and reducing costs.

Las Prácticas Integrativas y Complementarias (PIC) se presentan como métodos coadyuvantes, ayudando a obtener el éxito en determinados tratamientos clínicos y/o quirúrgicos, actuando en la prevención, ayudando en la cura y en el equilibrio psicosomático con el fin de restablecer la concordancia entre mente y cuerpo. El Consejo Federal de Odontología (CFO) ha regulado prácticas como la acupuntura, la hipnosis, la terapia floral y la fitoterapia, sin embargo, su aplicabilidad depende de la emisión de un título y su correcto registro en el Consejo (Resolución CFO 82/2008). Para la odontología, los PIC aportan nuevas herramientas para la atención integral del ser humano. En este trabajo, nos proponemos hacer una revisión bibliográfica sobre los PIC y la Odontología. Esta revisión bibliográfica se realizó mediante la búsqueda de artículos en las bases de datos Scielo, PubMed y Scholar Google desde el año 2000 hasta el 2021. Se encontraron artículos sobre los siguientes CFP que actúan conjuntamente con la Odontología: terapias florales, acupuntura, hipnodoncia, ozonoterapia, terapia láser, fitoterapia, homeopatía y odontología antroposófica. Estas prácticas tienen un gran valor porque promueven el bienestar sin causar daño al individuo, presentando pocos o ningún efecto secundario, proporcionando mayor seguridad a los pacientes, y favoreciendo la relación entre el paciente y el dentista, optimizando el tiempo de trabajo en el consultorio y reduciendo los costos.

Oral Health , Dentistry/methods , Dentists/education , Anthroposophy/history , Anxiety/therapy , Complementary Therapies/methods , Acupuncture Therapy/instrumentation , Cure in Homeopathy , Laser Therapy/instrumentation , Ozone Therapy , Floral Therapy , Hypnosis/instrumentation , Phytotherapy/instrumentation
Rev. Ciênc. Méd. Biol. (Impr.) ; 21(2): 214-217, out.2022. tab
Article in Portuguese | LILACS | ID: biblio-1400071


Introdução: o uso da fitoterapia como alternativa terapêutica, tem aumentado, no entanto ainda existem lacunas no conhecimento sobre o tema, o que impede a completa adesão da prática por parte dos profissionais de saúde. Objetivos: este trabalho teve como objetivoverificar o conhecimento sobre a prática da fitoterapia por profissionais de saúde em unidades de Estratégia Saúde da Família (ESF). Metodologia: foi realizado umestudo quantitativo, transversal, com aplicação de questionário contendo perguntas sobre a fitoterapia. Além disso, foi também desenvolvida uma análise descritiva, com frequência relativa e absoluta e análise de correlação através do teste de qui-quadrado de Pearson, utilizando teste de regressão binomial e multinominal. Resultados: participaram da pesquisa, 156 profissionais de saúde, distribuídos em 20 ESF do município de Rondonópolis-MT, sendo 24 enfermeiros, 8 médicos, 7 odontólogos, 4 farmacêuticos, 6 psicólogos, 10 técnicos em enfermagem, 88 agentes comunitários de saúde, 7 técnicos em saúde bucal, 1 técnico de farmácia e 1 educador físico. Destaca-se que 58% não souberam explicar a diferença entre fitoterápicos e plantas medicinais, 52% não sabiam realizar orientações nem citar o nome de medicamentos proveniente das plantas (53%), 88% não fizeram curso ou disciplina na área. No entanto, 86% tem interesse em se qualificar no assunto. Dentre os profissionais prescritores, 72,1% afirmaram prescrever raramente ou não prescrever a fitoterapia em sua prática profissional. Conclusão: evidenciam-se falhas no conhecimento sobre a fitoterapia e a necessidade de capacitação aos profissionais que atuam nas ESF, de forma a se sentirem seguros para prescrever e orientar quanto aos riscos e benefícios do uso das plantas como alternativa terapêutica.

Introduction: the use of phytotherapy as a therapeutic alternativehas increased, however there are still gaps in knowledge on the subject, what stopping the full adherence to the practice by health professionals. Objectives: this work aimed to verify the knowledge about the practice of herbal medicine by health professionals in Family Health Strategy Units (FHS). Method: A quantitative study was carried out, cross-sectional study, with the application of a questionnaire containing questions about herbal medicine. In addition, a descriptive analysis was also carried out, using relative and absolute frequency and correlation analysis through Pearson's chi-square test, using binomial and multinomial regression test. Results: 156 health professionals participated in the research, distributed in 20 FHS in the city of Rondonópolis-MT, 24 nurses, 8 doctors, 7 dentists, 4 pharmacists, 6 psychologists, 10 nursing technicians, 88 community health agents, 7 technicians in oral health, 1 pharmacy technician and 1 physical educator. It is noteworthy that 58% could not explain the difference between herbal medicines and medicinal plants, 52% did not know how to provide guidance or mention the name of medicines derived from plants (53%), 88% did not take a course or discipline in the area. However, 86% are interested in qualifying in the subject. Among the prescribing professionals, 72.1% stated that they rarely or didn ́t prescribe phytotherapy in their professional practice. Conclusion: there is evidence of gaps in knowledge about herbal medicine and the need for training professionals working in the FHS, in order to feel safe to prescribe and guide about the risks and benefits of using plants as a therapeutic alternative.

Humans , Male , Female , Plants, Medicinal , Primary Health Care , National Health Strategies , Health Personnel , Phytotherapy , Epidemiology, Descriptive , Evaluation Studies as Topic
Rev. méd. Paraná ; 80(1): 1-2, jan. 2022.
Article in Portuguese | LILACS | ID: biblio-1381020


As plantas medicinais são de fácil aquisição sem receita médica. Algumas delas possuem comprovação científica para o efeito hipoglicemiante, outras não. O objetivo deste estudo foi conhecer a prevalência e o perfil do paciente que usa plantas medicinais como coadjuvantes no tratamento do diabete. Foram entrevistados 140 diabéticos e pré-diabéticos agrupados em quem fazia o uso dessa alternativa e os que não. Em conclusão, a prevalência foi de 15,7%, maior em mulheres. A medicação prescrita foi metformina. A planta mais utilizada foi a pata-de-vaca. O grupo em uso referiu melhora glicêmica com a terapia complementar quando questionados sobre a glicemia uma semana antes e na semana de uso

Medicinal plants are easily available without a prescription. Some of them have scientific proof for the hypoglycemic effect, others do not. The objective of this study was to know the prevalence and profile of patients who use medicinal plants as adjuncts in the treatment of diabetes. A total of 140 diabetics and pre-diabetics were interviewed, grouped into those who used this alternative and those who did not. In conclusion, the prevalence was 15.7%, higher in women. The medication prescribed was metformin. The most used plant was the pata-de-vaca. The group in use reported glycemic improvement with the complementary therapy when asked about the glycemia one week before and in the week of use

Adult , Plants, Medicinal , Therapeutics , Diabetes Mellitus , Phytotherapy , Metformin
Int. j. high dilution res ; 21(2): 4-4, May 6, 2022.
Article in English | LILACS, HomeoIndex | ID: biblio-1396752


The purpose of the research is to studythe efficacy of phytotherapeutic, and homeopathic drugs. Phytotherapeutic drugs have been widely used in parasitology for many years. Also, homeopathic drugs such as Cina have anti-helminthicproperties. The possibility of using phytotherapeutic and high dilutiondrugs during the treatment of nematodedisease has been studied. Two experimental parasitological disease models (aspiculuriosis and trichinellosis) were used.Trichinellosisis a common model of nematodesinmice [1,2].Aspiculuris tetrapteraa pinworm of mice is an important parasite in institutions with mice colonies for both research and teaching purposes. The infection is generally asymptomatic. This study aimed to assess the protective efficiency of a homeopathic drug such as Cina C6cH, sphagnum,and its complex against experimental trichinosis and aspiculuriosis. Methods:An assay was carried out on 80 white outbred mice. These were divided into 6 groups of ten mice each. Groups1 and 4 had sphagnum q.s. per os; groups2 and 5 -desoldering dissolved in water Cina C6cH one time a day per os, the groups3 and 6 received complex sphagnum+Cina C6cHone time a day per os. Groups1-3 were inoculated with a dose of 80 ± 5 units of T. spiralislarva per mouse, groups 4-6 had spontaneous aspiculuriosis, and group 7 had T. spiralis, group 8 had Aspiculuris tetraptera. After 60 days of trichinellosis incubation, process the mice were euthanized and dissected for evaluation.Results:Maximum protection was obtained in the group of mice 3: T. spiralisdetected larvae in animals was 650.5±25.1 larva/animal. Group N2 (Cina C6cH) presented 2840.5±183.3 larva/animal. This was less than the control group (4485±430.6 larva/mouse). Also,groups 4-6 of mice with aspiculuriosis showed 75%, 80%,and 86% efficacy against nematodes.

Cina maritima , Trichinella spiralis , Phytotherapy
Int. j. cardiovasc. sci. (Impr.) ; 35(2): 214-219, Mar.-Apr. 2022. tab
Article in English | LILACS | ID: biblio-1364976


Abstract Background Various studies are ongoing related to the radioprotective agents. Herbal preparations are currently becoming popular because of their beneficial effects with fewer side effects compared to the synthetic/semi-synthetic medicines, and Nigella sativa oil (NSO) is only one of them. Objective To investigate NSO for its antioxidant effects on the heart tissue of rats exposed to ionizing radiation (IR). Methods Thirty six male albino Wistar rats, divided into four groups, were designated to group I (IR plus NSO group) that received both 5 Gray of gamma IR to total cranium and NSO; group II (IR alone group) that received IR plus saline, group III (control group of NSO) that received saline and did not receive NSO or IR; group IV (control group) that received only sham IR. Alterations in Total antioxidant status (TAS) and Total oxidant status (TOS), Oxidative stres index (OSI), Sulhydryl group (SH), Lipid hydroperoxide (LOOH), Paraoxonase (PON) levels, Arylesterase (ARE) and Ceruloplasmin (CER) activities in homogenized heart tissue of rats were measured by biochemical methods. Results In heart tissue of the rats in the IR alone group (group II) LOOH, TOS and OSI levels were found to be higher, ARE activity and TAS level were found to be lower than all of the other groups (p < 0.01). These results also support that IR increases oxidative stress and NSO's protective effect. Conclusion NSO would reduce the oxidative damage in the irradiated heart tissue in the experimental rat model.

Animals , Male , Rats , Radiation-Protective Agents/therapeutic use , Plant Oils/therapeutic use , Nigella sativa , Oxidative Stress/drug effects , Heart/radiation effects , Antioxidants/therapeutic use , Plants, Medicinal , Radiation-Protective Agents/analysis , Rats, Inbred Strains , Rats, Wistar , Oxidative Stress/radiation effects , Plant Preparations/therapeutic use , Cardiotoxicity/drug therapy , Heart/drug effects , Phytotherapy
Arq. ciências saúde UNIPAR ; 26(1): 1-12, Jan-Abr. 2022.
Article in Portuguese | LILACS | ID: biblio-1362657


Mesmo com a evolução do conhecimento científico, a utilização de plantas medicinais é uma das práticas mais antigas ainda realizadas pelo homem, especialmente pelos habitantes de comunidades e municípios do interior do Brasil, principalmente em regiões com baixos índices de desenvolvimento humano. O objetivo deste trabalho foi realizar um estudo etnobotânico sobre as plantas medicinais utilizadas pelos moradores de um bairro localizado em um município ribeirinho do interior do estado do Amazonas. Participaram do estudo cem indivíduos, e os dados obtidos pela pesquisa foram compilados por meio de um formulário, contendo 14 questões (objetivas e discursivas). Os resultados demonstraram que 95% dos moradores faziam uso de plantas medicinais. Foram citadas 89 espécies, pertencentes a 48 famílias botânicas, com destaque para a Lamiaceae. As plantas mais citadas foram: Plectranthus barbatus (boldo) ­ 6,1%, Citrus sinensis (laranjeira) ­ 5,8% e Allium sativum (alho) ­ 4,7%. No entanto, quando analisado o índice de concordância (porcentagem de uso principal = CUP), a Citrus sinensis (laranjeira) apresentou um CUP de 80,9%, seguida por Plectranthus barbatus (boldo) e Disphania ambrosioides (mastruz), com 68,1% e 61,5%, respectivamente. Com relação ao modo de preparo, 61,1% citaram infusão, e as principais enfermidades tratadas foram as dores de estômago, com 13,1%. É importante enfatizar a necessidade de mais estudos acerca dos reais benefícios dessas ervas, a fim de que a divulgação de tais informações possa complementar o conhecimento empírico já difundido entre a população local. Dessa forma, será possível ampliar o conhecimento etnobotânico como um todo e, consequentemente, promover saúde e bem-estar.

Despite the evolution of scientific knowledge, the use of medicinal plants is one of the oldest practices still used by men and, especially by the inhabitants of communities and municipalities of the interior of Brazil, mainly in regions with low human development rates. The purpose of this work was to perform an ethnobotanical study on medicinal plants used by residents of a neighborhood located in a riverside city in the interior of the state of Amazonas. A total of 100 individuals participated in the study, with data being obtained through the use of a form containing 14 open and closed-ended questions. The results showed that 95% of the residents used medicinal plants. A total of 89 species, belonging to 48 botanical families were mentioned, with emphasis to Lamiaceae. The plants that were most frequently mentioned were Plectranthus barbatus (locally known as boldo) ­ 6.1%; Citrus sinensis (orange tree) ­ 5.8%; and Allium sativum (garlic) ­ 4.7%. However, when analyzing the agreement index (percentage of main use = CUP), Citrus sinensis (orange tree) presented a CUP of 80.9%, followed by Plectranthus barbatus (boldo) and Disphania ambrosioides (Mexican tea), with 68.1 and 61.5%, respectively. In relation to the method of preparation, 61.1% cited infusion, with the main disorder treated being stomachache, with 13.1%. It is important to emphasize the need for further studies on the actual benefits of these herbs so that the dissemination of the information can complement the already widespread empirical knowledge among the local population. Thus, it will be possible to expand the ethnobotanical knowledge as a whole and, consequently, promote health and well-being.

Humans , Male , Female , Adult , Middle Aged , Aged , Plants, Medicinal/adverse effects , Ethnobotany , Tea/adverse effects , Agricultural Cultivation , Lamiaceae/adverse effects , Peumus/adverse effects , Citrus sinensis/adverse effects , Diarrhea/prevention & control , Influenza, Human/therapy , Juices , Inflammation/prevention & control , Phytotherapy
Rev. bras. med. fam. comunidade ; 17(44): 3046, 20220304. ilus, tab
Article in Portuguese | LILACS, ColecionaSUS | ID: biblio-1380391


Problema: Atualmente, o paradigma da produção de saúde é prodigalizado por uma miríade de interesses mercantis galanteadores do modelo biomédico, que supervaloriza o conhecimento científico moderno. Mesmo que seja desprestigiado pela soberania científica, cerca de 70% do uso popular das plantas medicinais é confirmado cientificamente, e esses saberes não institucionais são frequentes nas práticas cotidianas. Segundo dados da Organização Mundial da Saúde (OMS), 80% da população de países em desenvolvimento utiliza-se de práticas tradicionais na atenção primária à saúde e, desse total, 85% fazem uso de plantas medicinais. No Brasil, 82% dos brasileiros usam produtos à base de plantas medicinais para cuidar da saúde. Perante este descompasso, a atenção primária à saúde destaca-se como espaço estratégico para adubar o terreno das práticas fitoterápicas. Metodologia: Trata-se de um estudo descritivo, qualitativo, do tipo relato de experiência, sobre o desenvolvimento de um jardim medicinal localizado numa Unidade de Saúde da Família do município de Recife, Pernambuco. Utilizou-se um registro sistemático das atividades por meio da confecção de um diário de campo com registro fotográfico, complementado por levantamento bibliográfico e pesquisa documental. Resultados: O projeto perpassou pelas etapas informacional, estrutural e de plantio, constelando vários saberes com base no espírito da multiprofissionalidade e da participação comunitária. Ao fim, os esforços culminaram na efetivação de um jardim medicinal, propiciando um espaço para a troca de conhecimentos e experiências. Conclusão: Conclui-se que a estruturação de um jardim medicinal no âmbito da atenção primária à saúde conclama um prodigioso potencial no fortalecimento dos princípios que norteiam esse nível de atenção, reposicionando o usuário no centro do modelo de cuidado e ampliando as opções terapêuticas eficazes e de baixo custo.

Problem: Currently, the paradigm of health production is lavished by a myriad of commercial interests, gallant in the biomedical model that overestimates modern scientific knowledge. Even though they are discredited by scientific sovereignty, about 70% of the popular use of medicinal plants is scientifically confirmed and this non-institutional knowledge is common in everyday practices. According to data from the World Health Organization (WHO), 80% of the population in developing countries use traditional practices in primary health care and, of that total, 85% make use of medicinal plants. In Brazil, approximately 82% of Brazilians use herbal products to take care of their health. Before this mismatch, primary health care highlights as a strategic space to fertilize the terrain of herbal practices. Methodology: This is a descriptive, qualitative, experience report type study, on the development of a medicinal garden located in a Family Health Unit in the city of Recife, Pernambuco. A systematic record of activities was used by making a field diary with a photographic record, complemented by a bibliographical survey and documentary research. Results: The project passed through the Informational, Structural and Planting stages, gathering several types of knowledge based on the spirit of multiprofessionality and community participation. In the end, efforts culminated in the growth of a medicinal garden, providing a space for the exchange of learning and experiences. Conclusion: Can be concluded that the structuring of a medicinal garden in the scope of primary health care calls for a prodigious potential in strengthening the principles that guide this level of care, repositioning the user to the center of the care model and expanding the effective therapeutic options and low cost.

Problema: Actualmente, el paradigma de la producción de salud está prodigado por una miríada de intereses comerciales, galanteos en el modelo biomédico que sobreestima el conocimiento científico moderno. Si bien están desacreditados por la soberanía científica, cerca del 70% del uso popular de las plantas medicinales está científicamente confirmado y este conocimiento no institucional es común en las prácticas cotidianas. Según datos de la Organización Mundial de la Salud (OMS), el 80% de la población de los países en vías de desarrollo utiliza prácticas tradicionales en la atención primaria de salud y, de ese total, el 85% hace uso de plantas medicinales. En Brasil, aproximadamente el 82% de los brasileños utiliza productos a base de plantas medicinales para cuidar su salud. Ante este desajuste, la atención primaria de salud se destaca como un espacio estratégico para abonar el terreno de las prácticas fitoterapéuticas. Metodología: Se trata de un estudio descriptivo, cualitativo, tipo relato de experiencia, sobre el desarrollo de un jardín medicinal ubicado en una Unidad de Salud Familiar en la ciudad de Recife, Pernambuco. Se utilizó un registro sistemático de actividades para su desarrollo mediante la confección de un diario de campo con registro fotográfico, complementado con un relevamiento bibliográfico y una investigación documental. Resultados: El proyecto pasó por las etapas Informativa, Estructural y Siembra, estableciendo diversos conocimientos basados en el espíritu de multiprofesionalidad y participación comunitaria. Al final, los esfuerzos culminaron con el establecimiento de un jardín medicinal, proporcionando un espacio para el intercambio de conocimientos y experiencias. Conclusión: Se concluye que la estructuración de un jardín medicinal en el ámbito de la atención primaria de salud exige un potencial prodigioso en el fortalecimiento de los principios que orientan este nivel de atención, reposicionando al usuario en el centro del modelo de atención y ampliando la eficacia terapéutica. opciones y bajo costo.

Humans , Plants, Medicinal , Primary Health Care , Gardens , Phytotherapy
Rev. bras. med. fam. comunidade ; 17(44): 2521, 20220304.
Article in Portuguese | LILACS, ColecionaSUS | ID: biblio-1380404


Introdução: O uso da fitoterapia no cuidado em saúde é acessível, confiável e culturalmente aceito, reconhecendo-se que cerca de 80% da população mundial faz uso das plantas medicinais. No Sistema Único de Saúde (SUS), com o movimento da Reforma Sanitária e os interesses popular e institucional, foi construída a Política Nacional de Plantas Medicinais e Fitoterápicos, que incentivou a implantação de diversos programas de fitoterapia no Brasil. Apesar dessa ascensão da fitoterapia no SUS, a medicalização segue influenciando a prática clínica e tornando os indivíduos cada vez mais suscetíveis a intervenções desnecessárias, que muitas vezes acabam causando danos. Objetivo: Debater possibilidades de uso da fitoterapia no enfrentamento da sobremedicalização para promover a prevenção quaternária na Atenção Primária à Saúde. Métodos: Trata-se de um ensaio teórico elaborado com base na contextualização da possibilidade de enfrentamento da medicalização no âmbito do SUS, com o uso da fitoterapia. Resultados: O referencial teórico partiu de uma breve revisão do avanço da medicalização no SUS, considerando em seguida a fitoterapia como prática acessível e difundida entre a população brasileira como possibilidade para reduzir a medicalização ao ser correlacionada com o método clínico centrado na pessoa. Conclusões: A fitoterapia pode ser uma aliada da prática da prevenção quaternária ao tornar possível o encontro do saber tradicional com o técnico-científico, viabilizando um modo de cuidado alternativo à lógica medicalizadora.

Introduction: The use of phytotherapy in health care is accessible, reliable, and culturally accepted, and it is recognized that about 80% of the world population makes use of medicinal plants. In the Unified Health System (Sistema Único de Saúde ­ SUS), based on the Sanitary Reform movement and popular and institutional interests, the National Policy on Medicinal Plants and Phytotherapeutics was created, which encouraged the implementation of several phytotherapy programs in Brazil. Despite this rise of phytotherapy in the SUS, medicalization continues to influence clinical practice and make individuals increasingly susceptible to unnecessary interventions that often end up causing damage. Objective: To discuss possibilities of using phytotherapy to face overmedicalization to promote quaternary prevention in Primary Health Care. Methods: This is a theoretical essay based on the contextualization of the possibility of facing medicalization within the SUS from the perspective of Phytotherapy. Results: The theoretical framework started with a brief review of the advance of medicalization in the SUS, then considering phytotherapy as an accessible and widespread practice among the Brazilian population as a possibility to reduce medicalization when correlated with the Person-Centered Clinical Method. Conclusions: Phytotherapy can be an ally of the practice of quaternary prevention by making it possible to meet traditional and technical-scientific knowledge, enabling an alternative care method to the medicalizing logic.

Introducción: El uso de la fitoterapia en el cuidado de la salud es accesible, confiable y culturalmente aceptado, y se reconoce que cerca del 80% de la población mundial hace uso de plantas medicinales. En el SUS, con base en el movimiento de Reforma Sanitaria y los intereses populares e institucionales, fue creada la Política Nacional de Plantas Medicinales y Fitoterapéuticos, que incentivó la implementación de varios programas de fitoterapia en Brasil. A pesar de este auge de la fitoterapia en el SUS, la medicalización continúa influyendo en la práctica clínica y hace que los individuos sean cada vez más susceptibles a intervenciones innecesarias que muchas veces terminan causando daños. Objetivo: Discutir las posibilidades del uso de la fitoterapia para enfrentar la sobremedicalización para promover la prevención cuaternaria en la Atención Primaria de Salud. Métodos: Se trata de un ensayo teórico basado en la contextualización de la posibilidad de enfrentar la medicalización en el SUS desde la perspectiva de la Fitoterapia. Resultados: El referencial teórico partió de una breve revisión del avance de la medicalización en el Sistema Único de Salud, considerando luego la fitoterapia como práctica accesible y difundida entre la población brasileña como posibilidad de reducción de la medicalización cuando se correlaciona con el Método Clínico Centrado en la Persona. Conclusiones: La fitoterapia puede ser un aliado de la práctica de la prevención cuaternaria al posibilitar el encuentro con los saberes tradicionales y técnico-científicos, posibilitando un método de atención alternativo a la lógica medicalizante.

Humans , Primary Health Care , Unified Health System , Medicalization , Medical Overuse/prevention & control , Quaternary Prevention , Phytotherapy
Bol. latinoam. Caribe plantas med. aromát ; 21(1): 51-65, ene. 2022. tab, ilus
Article in English | LILACS | ID: biblio-1372343


Epidemiological evidence indicates that plant antioxidants activity can treat or help to prevent the development of various diseases. One species with great potential as an antioxidant is Curcuma longa. However, different extraction techniquescan influence isolated chemical compounds. This study investigated chemical composition and antioxidant activity of two rhizome extracts of C. longa: hydroethanolic, obtained by exhaustion (HECLex); and dried by a spray dryer (HECLsd). The phytochemical composition was evaluated by GC/MS. Antioxidant activity was evaluated using DPPH and FRAP assays. Total phenolic compounds and soil analyses were performed. The main components of HECLex were ar-turmerone, γ-curcumene, α-turmerone, and ß-sesquiphellandrene. The main components of HECLsd were 9,12,15-octadecatrienoic acid, 2, 3-bis([trimethylsilyl]oxy) propyl ester, verrucarol, and 1-monolinoleoylglycerol trimethylsilyl ether. HECLsd had significantly higher levels of phenolic compounds and higher antioxidant capacity compared with HECLex. In conclusion, processes of the preparation of C. longarhizomes alter the chemical components and consequently their biological activity.

La evidencia epidemiológica indica que la actividad de los antioxidantes de las plantas pueden tratar o ayudar a prevenir el desarrollo de diversas enfermedades. Una especie con gran potencial como antioxidante es Curcuma longa. Sin embargo, diferentes técnicas de extracción pueden influir en los compuestos químicos aislados. Este estudio investigó la composición química y la actividad antioxidante de dos extractos de rizoma de C. longa: hidroetanólico, obtenido por agotamiento (HECLex); y se seca con un secador por pulverización (HECLsd). La composición fitoquímica se evaluó mediante GC/MS. La actividad antioxidante se evaluó mediante ensayos DPPH y FRAP. Se realizaron análisis de suelos y compuestos fenólicos totales. Los componentes principales de HECLex fueron ar-turmerona, γ-curcumene, α-turmerone y ß-sesquiphellandrene. Los componentes principales de HECLsd fueron ácido 9,12,15-octadecatrienoico, éster 2,3-bis ([trimetilsilil] oxi) propílico, verrucarol y éter 1-monolinoleoilglicerol trimetilsilil. HECLsd tenía niveles significativamente más altos de compuestos fenólicos y mayor capacidad antioxidante en comparación con HECLex. En conclusión, los procesos de preparación de los rizomas de C. longa alteran los componentes químicos y consecuentemente su actividad biológica.

Plant Extracts/pharmacology , Curcuma/chemistry , Antioxidants/pharmacology , Plant Extracts/chemistry , Dietary Supplements , Diarylheptanoids/chemistry , Phenolic Compounds/analysis , Free Radicals , Gas Chromatography-Mass Spectrometry , Phytotherapy , Antioxidants/chemistry
Journal of Integrative Medicine ; (12): 292-304, 2022.
Article in English | WPRIM | ID: wpr-939886


Peperomia pellucida (L.) Kunth is a medicinal plant used to manage inflammatory illnesses such as conjunctivitis, and gastrointestinal and respiratory tract disorders in tropical and subtropical regions. However, little is known about its pharmacological mechanism of action against eye diseases. This review aims to critically discuss the phytochemistry, pharmacology and toxicology of P. pellucida as well as its roles in the treatment of cataract, glaucoma and diabetic retinopathy. Recent developments in the uses of P. pellucida for healthcare and nutraceutical products by the pharmaceutical industry are also covered in this review. For this review, a literature search was performed with PubMed, ScienceDirect, SciFinder Scholar and Scopus databases, using relevant keywords. Among the various phytochemicals identified from P. pellucida, β-caryophyllene, carotol, dillapiole, ellagic acid, pellucidin A, phytol and vitexin exhibit strong pharmacological activities within the mitogen-activated protein kinase and nuclear factor-κB signalling pathways in inflammatory eye diseases. The antihypertensive, anti-inflammatory, antioxidant, antihyperglycemic and anti-angiogenic activities displayed by P. pellucida extracts in many in vitro, in vivo and clinical studies suggest its potential role in the management of inflammatory eye diseases. P. pellucida extract was non-toxic against normal cell lines but displayed mild toxicity in animal models. The growing public interest in P. pellucida has inspired the nutraceutical and pharmaceutical industries to process the plant into health products. Although the potential pharmacological mechanisms against eye diseases have been summarized, further studies of the interactions among constituent phytochemicals from P. pellucida within various signalling pathways shall support the use of the plant as an alternative therapeutic source.

Animals , Ethnopharmacology , Eye Diseases/drug therapy , Peperomia , Phytochemicals/therapeutic use , Phytotherapy , Plant Extracts/therapeutic use , Plants, Medicinal
Ibom Medical Journal ; 15(2): 166-174, 2022. tables
Article in English | AIM | ID: biblio-1380086


Context: Despite the commonness of polyherbal therapy among the locals in the treatment of malaria in Nigeria, there are no adequate data on the therapeutic potentials and safety profile of these herbal combinations. The use of these plants in combination in the treatment of suspected and confirmed malaria infection is very common among the Niger Delta dwellers in Nigeria. Aim: To evaluate the therapeutic potential of co-administration of Hippocratea Africana, a medicinal plant with well documented antimalarial properties, and Eremomastax speciosa, a tropical plant with well reported antianaemic potential and haematoprotective properties. Materials and Methods: Thirty albino mice, whose weights ranged between 32 - 37g, were divided into five groups having six mice in each. Clinical features, weight changes and parasite clearance were evaluated to determine therapeutic potential of treatments. An inoculum which consisted of 5 x 107 Plasmodium berghei infested erythrocytes per ml of blood from a donor mouse with 64% parasitaemia was injected into each mouse by intraperitoneal route. The mice were kept at room temperature of 28.0 ± 20C for 7 days for the parasite to develop. A non-parasitized mice group served as normal control. After parasitaemia was confirmed using standard procedure, 200mg/kg and 300mg/Kg body weights of Hippocratea Africana root bark and Eremomastax speciosa leaf extracts respectively, were administered by oral routes to the respective groups of mice for 6 days. A parasitized group was treated with fixed doses of 3mg/kg body weight of Artemether and 18mg/kg body weight of Lumefantrine. Another parasitized group was left untreated. Results: Mice treated concurrently with the extracts of H. africana and E. speciosa showed a significant improvement in clinical signs in comparison to the untreated group. The mean body weights of mice administered both extracts was significantly (P < 0.05) increased when compared to the parasitized untreated mice and those treated with extracts separately. The mice treated concurrently with the two extracts also showed significant (P < 0.05) reduction in percentage parasitaemia and significant (P < 0.05) increase in percentage parasite clearance comparable to that of Artemether-lumefantrine. The parasitized untreated group recorded 50% mortality, while the group treated concurrently with the two extracts did not record any mortality.

Hippocrateaceae , Therapeutics , Apocynaceae , Malaria , Phytotherapy , Mice
Braz. j. biol ; 82: e237642, 2022. tab
Article in English | LILACS | ID: biblio-1249264


Abstract The aim of this research is to make a survey of the socio-environmental characteristics and the ethnobotanical study of medicinal plants used in a traditional community in the Brazilian Northeast, Alagoas. The study was made based on visits with the application of a questionnaire with questions related to the socio-economic element and on the diversity of plants used in herbal medicine. The research was made from March/2019 to February/2020, where families and interviewed plant exhibitors were interviewed for botanical identification. The studied community, which were 24 interviewees, was compiled by residents of the Quilombola community from Pau D'arco in Arapiraca city - Alagoas. Residents interviewed, 15 (62.5%) attended between 56 to 80 years, 11 interviewees about 46% were born in the community and 13 (54%) had a fundamentally incomplete nature. At the end, there were mentioned 30 plant species used for phytotherapeutic purposes, from which presents bigger usage as plants against arterial hypertension (Salvia rosmarinus Schleid), diabetes Mellitos (Croton heliotropiifolius Kunth), pain and inflammation (Alternanthera tenella Colla), present the biggest number of species in the community. The species cited are related to numerous medicinal uses, among which there will be predominant associations associated with cardiovascular and inflammatory processes. The tea is the main way of preparing plants. It is perceived that medicinal plants are only widely used by this Quilombola community of and growth of the crops in the backyard are considered a tradition.

Resumo Esta pesquisa teve como objetivo realizar um levantamento das características socioambientais e estudo etnobotânico de plantas medicinais utilizadas por uma comunidade tradicional do nordeste brasileiro, Alagoas, Brasil. O estudo se deu por meio de visitas com aplicação de um questionário contendo perguntas relacionadas aos fatores socio-econômicos e sobre a diversidade das plantas utilizadas como medicinais. O trabalho foi realizado no período de março/2019 a fevereiro/2020, onde foram entrevistadas famílias e catalogadas amostras de plantas para identificação botânica. A população estudada, com 24 entrevistados, foi composta por moradores da comunidade Quilombola Pau D'arco da cidade de Arapiraca - Alagoas. Dos moradores entrevistados, 15 (62,5%) apresentavam idade entre 56 e 80 anos, 11 dos entrevistados cerca de 46%, são naturais da comunidade e 13 (54%) possuíam ensino fundamental incompleto. Ao todo, foram citadas 30 espécies de plantas utilizadas para fins terapêuticos, das quais apresentam maior utilização as plantas contra a hipertensão arterial (Salvia rosmarinus Schleid), diabetes Mellitos (Croton heliotropiifolius Kunth), dor e inflamação (Alternanthera tenella Colla). As espécies citadas estão relacionadas a inúmeras utilizações medicinais, entre os quais predominaram as doenças associadas ao aparelho cardiovascular e processos inflamatórios. O chá é principal forma de preparo das plantas. Percebe-se que as plantas medicinais são amplamente utilizadas por essa comunidade quilombola e o cultivo no quintal é considerado uma tradição.

Humans , Plants, Medicinal , Brazil , Surveys and Questionnaires , Ethnobotany , Phytotherapy
Braz. j. biol ; 82: e243811, 2022. tab, graf
Article in English | LILACS | ID: biblio-1249262


Abstract An ethnobotanical study was conducted to document indigenous medicinal plants and their usage from knowledgeable and elderly persons in Razzar and Gadoon valley of Swabi and Allai and Tanawal valley of Hazara region of Pakistan during 2016-2019. Several systematic field visits and questionnaire surveys were carried out in selected sites of the study area to gather relevant information from the local community. Rapid assessment method was adopted for data collection by interviewing the local people having enough knowledge of medicinal plants use for treatment of different ailments. UV (UV) formula was applied to calculate the relative importance of medicinal plant species in each site of the study area. In the present study, 221 medicinal plants belonging to 105 families have been reported through 580 respondents (385 males, 138 females and 57 local health healer) from the Swabi and Hazara region. The main sources of herbal medicines were leaves (21%) followed by fruits (21%), seeds (17%), whole plants (14%), roots (9%), bark (9%), flowers (7%) and gum (2%). Mentha spicata L. and Berberis lycium Royle were reported with highest UV (UV) i.e. 0.92 and 0.68 in Razzar tehsil and Gadoon valley of Swabi, whereas Mentha longifolia L and Geranium wallichianum D were reported with highest UV i.e. (0.65) and (0.88) in Allai and Tanawal valley of Hazara region, respectively. It was concluded that Swabi and Hazara region is rich in medicinal plants species and associated traditional knowledge. Moreover, ethno-medicines have played significant role in the indigenous healthcare system of the study area. However, uprooting the entire plant for ethno-medicine is a big threat to conservation of medicinal plants diversity in the study area.

Resumo Um estudo etnobotânico foi realizado para documentar as plantas medicinais indígenas e seu uso por pessoas experientes e idosas em Razzar e Gadoon, no vale de Swabi e no vale Allai e Tanawal da região de Hazara, no Paquistão, durante 2016 a 2019. Várias visitas sistemáticas de campo e pesquisas por questionário foram realizadas em locais selecionados da área de estudo para coletar informações relevantes da comunidade local. O método de avaliação rápida foi adotado para a coleta de dados por meio de entrevistas com a população local, com conhecimento suficiente do uso de plantas medicinais para o tratamento de diferentes enfermidades. A fórmula UV (UV) foi aplicada para calcular a importância relativa das espécies de plantas medicinais em cada local da área de estudo. No presente estudo, 221 plantas medicinais pertencentes a 105 famílias foram relatadas por 580 entrevistados (385 homens, 138 mulheres e 57 curandeiros locais) da região de Swabi e Hazara. As principais fontes de medicamentos fitoterápicos foram folhas (21%), seguidas de frutas (21%), sementes (17%), plantas inteiras (14%), raízes (9%), cascas (9%), flores (7%) e goma (2%). Mentha spicata L. e Berberis lycium Royle foram relatados com maior UV (UV), ou seja, 0,92 e 0,68 em Razzar tehsil e vale Gadoon de Swabi, enquanto Mentha longifolia L. e Geranium wallichianum D. foram relatados com maior UV, isto é, 0,65 e 0,88 no vale Allai e Tanawal da região de Hazara, respectivamente. Concluiu-se que a região de Swabi e Hazara é rica em espécies de plantas medicinais e conhecimentos tradicionais associados. Além disso, etnomedicamentos têm desempenhado um papel significativo no sistema de saúde indígena da área de estudo. No entanto, arrancar a planta inteira para etnomedicina é uma grande ameaça à conservação da diversidade de plantas medicinais na área de estudo.

Humans , Male , Female , Aged , Plants, Medicinal , Pakistan , Ethnobotany , Phytotherapy , Medicine, Traditional
Braz. arch. biol. technol ; 65: e22210032, 2022. tab, graf
Article in English | LILACS | ID: biblio-1364475


Abstract Zika fever is a viral infection of great relevance in public health, especially in tropic regions, in which there is a predominance of mosquitoes of the genus Aedes, vectors of the disease. Microcephaly in neonatal children and Guillain-Barré syndrome in adults can be caused by the action of the Zika virus (ZIKV). Non-structural proteins, such as NS2B, NS3 and NS5, are important pharmacological targets, due to their action in the life cycle. The absence of anti-Zika drugs raises new research, including prospecting for natural products. This work investigated the in silico antiviral activity of bixin and six other derived molecules against the Zika viral proteins NS2B-NS3 and NS5. The optimized structure was subjected to molecular docking to characterize the interaction between bixinoids and ZIKV non-structural proteins, where significant interactions were observed with amino acid residues in the catalytic site in each enzyme. These results suggest that bixin and ethyl bixin has the potential to interfere with the enzymatic activity of NS2B, NS3 and NS5, thus being an indication of being a promising anti-Zika agent.

Antiviral Agents/therapeutic use , Plant Extracts/therapeutic use , Bixa orellana/therapeutic use , Zika Virus Infection/drug therapy , Phytotherapy , Virus Replication/drug effects
Braz. arch. biol. technol ; 65: e22210268, 2022. tab
Article in English | LILACS | ID: biblio-1364472


Abstract: Sulfur mustard is one of the chemical warfare agent. It rapidly reacts with the cutaneous tissues and other tissues, leading to various devastating long-term effects on human health. Mustard-exposed veterans suffer from its chronic skin problems, including itching, burning sensation, and eczema. We aimed to evaluate the protective effects of Myrtus communis L. (myrtle) on chronic skin lesions and quality of life of sulfur mustard-exposed veterans. In this randomized, double-blind clinical trial, 60 sulfur mustard-exposed patients were evaluated. Thirty patients received myrtle essence 5% cream (case group) and 30 patients received Eucerin cream (placebo group) twice in a day for one month. Then, We assessed the chronic skin problems and itching-related parameters (such as the itching time, severity, distribution, frequency, and calculated itching score), duration of sleep, number of waking up at night, and quality of life in the both groups. Our analysis of data revealed that application of myrtle cream effectively decreased skin problems including; itching and burning sensation. Additionally, myrtle markedly decreased skin lesion symptoms such as excoriation in the case group as compared with before treatment. Noticeably, myrtle cream significantly improved quality of life of the patients in the case group. The present study provides more in-depth information regarding the protective role of myrtle on the sulfur mustard-induces skin complication. Also, myrtle effectively improved quality of life of the sulfur mustard-exposed veterans.

Humans , Middle Aged , Skin Diseases/chemically induced , Plant Extracts/therapeutic use , Chemical Warfare Agents/toxicity , Myrtus communis/therapeutic use , Phytotherapy , Mustard Gas/toxicity , Pruritus/chemically induced , Quality of Life , Veterans , Indicators of Quality of Life , Eczema/chemically induced , War Exposure/adverse effects , Iran