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Arq. bras. oftalmol ; 83(2): 153-156, Mar.-Apr. 2020. graf
Article in English | LILACS | ID: biblio-1088973


ABSTRACT A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. A histological diagnosis of pilomatrix carcinoma was established. To prevent recurrence after surgery, we added bevacizumab (25 mg/mL, 1.25 mg/mL per drop) eye drops four times per day for three months. At the one-year follow-up, the patient showed no evidence of local recurrence or distant metastasis after initial excision and remains under close follow-up. Pilomatrix carcinoma should be considered in the differential diagnosis of a caruncular mass.

RESUMO Um homem de 45 anos apresentou história de massa na carúncula no olho direito durante 3 meses. Uma biópsia incisional foi realizada 1 mês antes por outro especialista e o laudo histopatológico mostrava carcinoma basocelular. A massa foi completamente excisada, com uma margem de segurança de 2 mm, e a grande lesão conjuntival foi reconstruída com uma folha de aloenxerto de membrana amniótica. Foi estabelecido um diagnóstico histológico de carcinoma pilomatricial. Para evitar a recorrência após a cirurgia, adicionamos colírio de bevacizumabe (25 mg/mL, 1,25 mg/mL por gota) quatro vezes ao dia durante três meses. No seguimento de 1 ano, o paciente não apresentou evidência de recidiva local ou metástase distante após a excisão inicial e continua sob acompanhamento próximo. O carcinoma pilomatricial deve ser considerado no diagnóstico diferencial de uma massa caruncular.

Humans , Male , Middle Aged , Carcinoma, Basal Cell/pathology , Pilomatrixoma/pathology , Conjunctival Neoplasms/pathology , Lacrimal Apparatus Diseases/pathology , Biopsy , Carcinoma, Basal Cell/surgery , Pilomatrixoma/surgery , Conjunctival Neoplasms/surgery , Hair Follicle/pathology , Hair Diseases/pathology , Lacrimal Apparatus Diseases/surgery
Rev. chil. dermatol ; 34(3): 102-105, 2018. ilus
Article in Spanish | LILACS | ID: biblio-995092


El Pilomatrixoma es un tumor anexial benigno. Presenta una variante histopatológica infrecuente denominada pilomatrixoma proliferante reportada en 1997 por Kaddu et al. Corresponde a una lesión compuesta predominantemente por una proliferación lobular de células basaloides, con atipia nuclear variable y figuras mitóticas, áreas focales que contienen material cornificado eosinófilo, junto con células sombra. Se propuso al pilomatrixoma proliferante como un subconjunto histopatológico distintivo del pilomatrixoma y se consideró como una variante proliferativa con un perfil histopatológico benigno. La dermatoscopía en este tumor, sobre todo en pacientes de edad avanzada, puede llegar a constituir una trampa dermatoscópica, que es difícil de diferenciar de otras lesiones, como el melanoma o el carcinoma de células basales. Existen múltiples reportes de casos en la literatura donde se informa de pilomatrixomas clásicos o proliferantes simulando otras neoplasias. Presentamos el caso de una paciente de 88 años con pilomatrixoma proliferante facial que simuló clínicamente un carcinoma de células escamosas y llevó a confusión diagnóstica inicial, se destacan las características histopatológicas y clínicas de los pilomatrixomas proliferantes.

Pilomatrixoma is a benign adnexal tumor. It has an infrequent histopathological variant called proliferating pilomatrixoma reported in 1997 by Kaddu et al. It corresponds to a lesion composed predominantly by a lobular proliferation of basaloid cells, with variable nuclear atypia and mitotic figures, focal areas containing eosinophilic cornified material, together with shadow cells. The proliferating pilomatrixoma was proposed as a distinctive histopathological subset of the pilomatrixoma and was considered as a proliferative variant with a benign histopathological profile. Dermatoscopy in this tumor, especially in elderly patients, can result in a dermatoscopic trap, which makes it difficult to differentiate from other lesions, such as melanoma or basal cell carcinoma. There are multiple reports of cases in the literature where classic or proliferating pilomatrixomas were reported simulating other neoplasms. We present the case of an 88-year-old patient with a proliferating facial pilomatrixoma that clinically simulated a squamous cell carcinoma and led to an initial diagnostic confusion, highlighting the histopathological and clinical characteristics of the proliferating pilomatrixoma.

Humans , Male , Aged, 80 and over , Skin Neoplasms/diagnosis , Carcinoma, Squamous Cell/diagnosis , Pilomatrixoma/diagnosis , Hair Diseases/diagnosis , Skin Neoplasms/pathology , Nose , Pilomatrixoma/pathology , Neoplasms, Squamous Cell/pathology , Dermoscopy , Diagnosis, Differential , Hair Diseases/pathology
Rev. chil. dermatol ; 34(2): 72-75, 2018. ilus
Article in Spanish | LILACS | ID: biblio-994884


El pilomatrixoma es una neoplasia anexial benigna, que habitualmente se presenta como pápula o nódulo subcutáneo, de crecimiento lento y asintomático. Es más frecuente en niños. El diagnóstico se basa en hallazgos clínicos, y la ecografía es útil como examen complementario. El tratamiento es su resección quirúrgica. Se presenta un caso infrecuente de pilomatrixoma quístico con verruga vulgar intraquística en un paciente adulto.

Pilomatricoma is a benign adnexal tumor, usually presenting as a slow growing asymptomatic subcutaneous papule or nodule. It is more common in children. The diagnosis is based on clinical findings, and ultrasound is useful as a complementary workup tool. Its treatment is surgical excision. We present a rare case of a cystic pilomatricoma with an intracystic verruca vulgaris in an adult patient.

Humans , Male , Middle Aged , Skin Neoplasms/pathology , Warts/pathology , Pilomatrixoma/pathology , Hair Diseases/pathology , Skin Neoplasms/surgery , Skin Neoplasms/diagnosis , Pilomatrixoma/surgery , Pilomatrixoma/diagnosis , Hair Diseases/surgery , Hair Diseases/diagnosis
Rev. AMRIGS ; 60(4): 370-373, out.-dez. 2016. ilus
Article in Portuguese | LILACS | ID: biblio-847858


Pilomatricoma é uma neoplasia folicular benigna relativamente rara. Pode ocorrer em qualquer idade, mas menos de 13% dos casos acontecem em pessoas com mais de 50 anos, sendo mais comum em mulheres (1,5 a 2,5 mulheres:1 homem). A localização mais frequente é a região cervical, seguida das áreas frontais, periorbitárias e pré-auriculares (1). Clinicamente, apresenta-se como um tumor subcutâneo ou intradérmico, endurecido e de crescimento lento. O diagnóstico pré-cirúrgico é quase sempre difícil (3). O tratamento padrão é o cirúrgico, com margens de segurança amplas para minimizar o risco de recorrência nas variantes malignas (2,3). Relatamos um caso atípico e exuberante de múltiplos pilomatricomas em membros superiores em um paciente do sexo masculino de 55 anos (AU)

Pilomatricoma is a relatively rare benign follicular neoplasm. It can occur at any age, but less than 13% of cases occur in people over 50 years old, and it is more common in women (1.5 to 2.5 women: 1 man). The most frequent location is the cervical region, followed by the frontal, periorbital and pre-auricular areas (1). Clinically it presents as a hardened and slowly growing subcutaneous or intradermal tumor. Preoperative diagnosis is almost always difficult (3). The standard treatment is surgical, with wide safety margins to minimize the risk of recurrence in malignant variants (2,3). We report an atypical and exuberant case of multiple pilomatricomas in upper limbs in a 55-year-old male patient (AU)

Humans , Male , Middle Aged , Pilomatrixoma/diagnosis , Pilomatrixoma/pathology , Diagnosis, Differential , Pilomatrixoma/surgery , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Upper Extremity
Bahrain Medical Bulletin. 2016; 38 (2): 108-109
in English | IMEMR | ID: emr-178831


Pilomatrixoma is a benign skin tumor that arises from the hair cell matrix. It is a rare tumor that commonly presents in certain locations of the body. We present a seventeen-year-old female with pilomatrixoma located in the lateral aspect of the right thigh. The tumor is rare and presented in a rare location

Humans , Female , Adolescent , Rare Diseases , Pilomatrixoma/pathology
An. bras. dermatol ; 90(3,supl.1): 94-96, May-June 2015. ilus
Article in English | LILACS | ID: lil-755790



Proliferating pilomatricoma is proliferative, rare tumor variant of pilomatricoma. It is a benign neoplasm of hair matrix that can have potentially involve local recurrence. We report the case of a 60-year-old man who presented an asymptomatic nodule on the scalp. Histological exam demonstrated a basaloid epithelium at the periphery, filled with eosinophilic cornified material containing shadow cells. The tumor was excised and there was no evidence of recurrence one year later.


Humans , Male , Middle Aged , Hair Diseases/pathology , Pilomatrixoma/pathology , Skin Neoplasms/pathology , Skin/pathology , Treatment Outcome , Tumor Burden
Dermatol. peru ; 24(2): 116-118, abr.-jun. 2014. ilus
Article in Spanish | LILACS, LIPECS | ID: lil-765235


El pilomatrixoma anetodérmico es una rara variante de pilomatrixoma, cuyo mecanismo etiopatogénico es desconocido. Se caracteriza por la presencia de una piel atrófica, plegada, con aspecto queloideo, que recubre un nódulo de consistencia dura. Su diagnóstico es clínico e histopatológico y el tratamiento es quirúrgico. Se reporta el caso de un paciente varón de 14 años con pilomatrixoma anetodérmico en omóplato derecho.

Anetodermic pilomatricoma is a rare variant of pilomatrixoma whose etiopathogenic mechanism is unknown. lts characterized by the presence of atrophic skin, fold, with keloidal appearance covering a hard nodule. The diagnosis is clinical and histopathological and the treatment is surgery. The case of a male patient of 14 years with anetodermic pilomatricoma in right shoulder blade is reported.

Humans , Male , Adolescent , Medical Illustration , Pilomatrixoma , Pilomatrixoma/diagnosis , Pilomatrixoma/pathology , Pilomatrixoma/therapy
KMJ-Kuwait Medical Journal. 2010; 42 (3): 222-226
in English | IMEMR | ID: emr-98638


Pilomatrixoma [PMX] is a benign skin appendage tumor with differentiation toward hair cells, particularly hair matrix. It has classic histomorphology. However, fine needle aspiration cytology [FNAC] diagnosis may be extremely dificult and it can be mistaken for a malignant tumor. To our knowledge there are isolated case reports and some handful of series of cases reported in the literature elaborating cytologic features of PMX. We describe clinical and cytological findings in a 29-year-old male patient with skin nodule on the right upper arm. We also review the literature and conclude that identification of unique constellation of cytological features, e.g., basaloid cells, ghost cells, refractile keratin material and foreign body giant cells etc., in appropriate clinical context are most helpful in diagnosis and obviate unnecessary radical surgery

Humans , Male , Hair Diseases , Pilomatrixoma/pathology , Biopsy, Fine-Needle , Review Literature as Topic
Arq. bras. oftalmol ; 72(3): 380-383, May-June 2009. ilus
Article in Portuguese | LILACS | ID: lil-521476


Pilomatricoma é um tumor benigno oriundo do folículo pilossebáceo, que surge como nódulo intradérmico durante a infância na maioria dos casos. Geralmente é recoberto por pele normal, alcança em média diâmetro de 1,5 cm e frequentemente não recidiva após exérese cirúrgica. Os autores descrevem um caso no qual uma lesão tumoral iniciou seu crescimento na região superciliar esquerda de um paciente de 26 anos, sendo realizada exérese total da mesma e diagnóstico através do exame anatomopatológico de pilomatricoma. Esta lesão teve um crescimento lento, de aproximadamente dois anos, segundo o paciente. Decorridos oito meses da intervenção cirúrgica houve novo crescimento tumoral no local, desta vez de maneira rápida e exacerbada e com ulceração de pequena área da pele que recobria a lesão, induzindo, portanto, suspeita de malignidade. Realizada nova exérese com margem de segurança, o exame anatomopatológico confirmou ser a lesão um pilomatricoma, não possuindo a peça cirúrgica sinais de malignização. O paciente encontra-se em seguimento há um ano, sem sinais de recidiva até o momento.

Pilomatricoma is a benign neoplasm originated in the pilosebaceous follicle wich appears as an intradermal nodule during childhood, in most cases. It is generally covered with normal skin, reaching a diameter of 1.5 cm on average, and it often shows no recurrence after surgical excision. The authors describe a case in wich a 26-year-old patient presented a tumoral lesion on the upper left superciliary area was submitted to total excision, and diagnosed as pilomatricoma by the histological study. According to the patient, this lesion had a progressive and slow growth of about two years. Eight months after the first surgical intervention, there was a new tumor growth in the region, this time quicker and worsen, with ulceration on the small skin area that covered the lesion, thus leading to malignity suspicion. After the conduction of a new excision within a security margin, the histological test confirmed that it was a pilomatricoma lesion and the piece displayed no sign of malignity. The patient has been followed up for one year, showing no signs of recurrence so far.

Adult , Humans , Male , Eyebrows , Hair Diseases , Pilomatrixoma , Skin Neoplasms , Diagnosis, Differential , Eyebrows/pathology , Hair Diseases/pathology , Hair Diseases/surgery , Neoplasm Recurrence, Local , Pilomatrixoma/pathology , Pilomatrixoma/surgery , Reoperation , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Time Factors
Arch. argent. dermatol ; 58(4): 161-164, jul.-ago. 2008. ilus
Article in Spanish | LILACS | ID: lil-501410


El pilomatrixoma es un tumor benigno con diferenciación hacia las células matriciales del folículo piloso. Usualmente se manifiesta como un nódulo firme, solitario y asintomático de crecimiento lento. Se trata de una neoplasia frecuente en la población pediátrica. El pilomatrixoma dispone de una amplia variedad de características clínicas; a menudo su diagnóstico es erróneo. El tratamiento es la excisión quirúrgica. El diagnóstico diferencial de pilomatrixoma también se debe considerar en pacientes adultos. Presentamos un caso clínico en un varón de 27 años con lesión tumoral clínicamente anetodérmica en muslo derecho cuya histología fue compatible con pilomatrixoma. Destacamos este caso por la baja frecuencia en adultos y su localización inusual.

Humans , Male , Adult , Pilomatrixoma/diagnosis , Pilomatrixoma/complications , Pilomatrixoma/pathology , Skin Neoplasms
Arch. argent. dermatol ; 57(4): 203-205, jul.-ago. 2007.
Article in Spanish | LILACS | ID: lil-508451


El pilomatrixoma es un tumor cutáneo epitelial benigno cuyo origen radica en las células de la matriz del folículo piloso. Es una patología que aparece con poca frecuencia. Considerando que el diagnóstico clínico de pilomatrixoma suele resultar dificultoso, el propósito de este trabajo es ratificar un signo que nos facilitó ese diagnóstico: la palpación de un tumor de consistencia pétrea, en el que se hacen evidentes planos unidos por aristas con el aspecto de un piedra facetada. Consideramos que el signo de la piedra facetada es patognomónico de pilomatrixoma. Este concepto fue publicado en un trabajo en 1989 en Medicina Cutánea.

Humans , Pilomatrixoma/diagnosis , Neoplasms, Adnexal and Skin Appendage/diagnosis , Pilomatrixoma/pathology
Arq. bras. oftalmol ; 70(3): 501-503, maio-jun. 2007. ilus, tab
Article in Portuguese | LILACS | ID: lil-459839


OBJETIVO: Relatar a experiência com pilomatrixoma palpebral no Hospital Universitário Prof°. Edgard Santos, em período de 30 anos. MÉTODOS: Revisão no Registro do Laboratório de Patologia Ocular, de todos os casos de tumores palpebrais no período de 1974 a 2004. Após a identificação dos casos de pilomatrixoma, foram coletados dados referentes a gênero, idade, tempo de sintomatologia, aspecto, localização e suspeita diagnóstica inicial. As lâminas coradas pela hematoxilina e eosina foram revisadas. RESULTADOS: Dentre os 621 casos de tumores palpebrais, quatro eram de pilomatrixoma (0,64 por cento). Três pacientes eram do sexo masculino. A idade média foi de 25 anos, variando de 8 a 54. O tempo de sintomatologia médio foi de cinco meses, variando de 2 a 12. Em três casos a lesão localizava-se na pálpebra inferior. Em apenas um caso o diagnóstico clínico foi correto. Ao exame anatomopatológico, dois casos apresentavam pseudocápsula. O caso cuja sintomatologia foi mais prolongada exibia predominância de células do tipo fantasma. Reação tipo corpo estranho foi vista em todos os casos, calcificação em apenas um. CONCLUSÕES: Trata-se de tumor benigno bastante raro, acometendo principalmente jovens. Devido a sua raridade e pleomorfismo à apresentação, dificilmente o diagnóstico clínico é correto.

PURPOSE: To report the experience with eyelid pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64 percent) were pilomatrixomas. Three patients were male. The mean age at diagnosis was 25 years (from 8 to 54). Mean duration of symptoms was 5 months (from 2 to 12). In three cases the lesion was located in the inferior lid. Only one patient had a correct clinical diagnosis. Two cases exhibited a pseudo-capsule on histology. The case with 12 months of history was composed mainly of shadow cells. Foreign body reaction was seen in all cases, calcification in only one. CONCLUSION: This is a very rare benign tumor of young patients. Due to its rarity and variable clinical presentation, clinical misdiagnosis is common.

Adult , Child , Female , Humans , Male , Middle Aged , Eyelid Neoplasms/pathology , Hair Diseases/pathology , Pilomatrixoma/pathology , Skin Neoplasms/pathology , Eyelid Neoplasms/surgery , Hair Diseases/surgery , Pilomatrixoma/surgery , Skin Neoplasms/surgery
Col. med. estado Táchira ; 15(2): 49-50, abr.-jun. 2006.
Article in Spanish | LILACS | ID: lil-531241


El pilomatrixoma es un tumor que deriva de la matrix del folículo piloso. Usualmente se manifiesta como un nódulo firme, solitario y asintomático. Es considerado como un tumor raro. Aproximadamente el 50 por ciento de las lesiones se observan en cabeza y cuello. Se presenta en la mayoría de veces en niños, pero su presentación en adultos es altamente reportada. Es más común en mujeres que en hombres. Su tratamiento se basa en la resección quirúrgica. Múltiples pilomatrixomas se han observado en asociación con distrofias musculares. La técnica anestésica ideal es aquella que permite mantener una adecuada estabilidad hemodinámica intraoperatoria, sin embargo los procedimientos extra e intracraneanos, están asociados a importantes variaciones en los estímulos nociceptivos, debido a lo cual se requiere frecuentes ajuste de la profundidad anestésica, el bloqueo somático de cabeza y cuello, proporciona una forma optima de anestesia, sola o como complemento de anestesia general, y produce una analgesia excelente en el período postoperatorio. En nuestro centro asistencial es frecuente el uso de bloqueo de cuero cabelludo, en los pacientes neuroquirúrgicos, a continuación se describe el uso de anestesia regional en un paciente masculino, con pilomatrixoma, realizada en el Instituto Autónomo Hospital Universitario de Los Andes.

Humans , Adult , Female , Anesthesia/methods , Creatinine/therapeutic use , Hair Follicle/abnormalities , Lidocaine/therapeutic use , Head and Neck Neoplasms/surgery , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/therapy , Lidocaine/pharmacology , Pilomatrixoma/surgery , Pilomatrixoma/pathology