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1.
Rev. méd. Urug ; 37(3): e37302, set. 2021. tab, graf
Article in Spanish | LILACS, BNUY | ID: biblio-1341550

ABSTRACT

Resumen: Las úlceras de pie diabético (UPD) generan un alto costo para el paciente y el sistema de salud. Una deficiente vascularización, la inhibición de la generación de factores de crecimiento y la migración celular, entre otros factores, influyen en su cronicidad. Los factores de crecimiento derivados de las plaquetas (PDGF) estimulan la quimiotaxis, la neovascularización y la regeneración tisular. Objetivo: evaluar la efectividad de una formulación de plasma rico en plaquetas autólogo (PRP) como una modalidad complementaria para el tratamiento de UPD, valorando su seguridad y efectos adversos. Materiales: estudio observacional. Se aplicó PRP a seis pacientes con UPD crónicas, Wagner II, III, con una media en el retraso de la cicatrización de 94 semanas. Se administró mediante punción y como gel sobre la lesión una vez por semana hasta el cierre de la úlcera o durante12 semanas. Las UPD se analizaron con respecto al área y su progresión mediante Mobile Wound Analyzer (MOWA), software de análisis de imágenes de úlceras. El porcentaje de reducción del área se calculó entre la medición inicial y la semana 12. Como criterio de mejoría se eligió una reducción >70% de la lesión. Resultados: predominó el sexo masculino con una media de edad de 53 años ± 7,3. Luego de 12 semanas de tratamiento, se reportó una reducción media del tamaño de la úlcera de 78%, con dos cicatrizaciones completas y dos en 99%. Un paciente recibió una amputación luego de presentar infección no controlada. Conclusión: la aplicación del PRP mejoró la regeneración de tejidos, acortando la duración de la úlcera, promoviendo su curación sin efectos adversos, al tiempo que eliminó la necesidad de procedimientos de manejo en una úlcera crónica.


Summary: Diabetic foot ulcers imply high expenditure for both patients and the health system. Vascular impairment, growth factor inhibition and cell migration, among other factors, affect the chronicity of the condition. Platelet-derived growth factors (PDGFs) stimulate chemotaxis, neovascularization and tissue regeneration. Objective: to evaluate effectiveness of a formulation of autologous platelet-rich plasma to complement the treatment of diabetic foot ulcer, assessing safety and adverse effects. Material: observational study. Platelet rich plasma was applied to six patients with chronic diabetic foot ulcer Wagner II, III, with an average delayed healing of 94 weeks. PRP gel was administered by puncture technique on the lesion, once a week until the ulcer healed or for 12 weeks. Diabetic foot ulcers were analysed in regards to surface area and progression through the Mobile Wound Analyzer (MOWA) software to analyse ulcer images. The area reduction percentage was calculated comparing the initial measurement and that of week 12. The improvement criteria was defined in a reduction that is >70% of the lesion. Results: men prevailed with an average age of 53 years ± 7.3. After 12 weeks of treatment an average reduction of 78% of the size of the ulcer was reported, two complete healings and two 99% healed. One patient required amputation because of uncontrolled infection. Conclusion: the application of PRP improved tissue regeneration and shortened the duration of the ulcer, promoting healing with no adverse effects, and it likewise eliminated the need for procedures to handle chronic ulcers.


Resumo: As úlceras do pé diabético (UPD) geram alto custo para o paciente e para o sistema de saúde. A vascularização deficiente, a inibição da geração de fatores de crescimento e migração celular, entre outros fatores, influenciam sua cronicidade. Os fatores de crescimento derivados de plaquetas (PDGF) estimulam a quimiotaxia, a neovascularização e a regeneração de tecidos. Objetivo: avaliar a eficácia de uma formulação autóloga de plasma rico em plaquetas (PRP) como modalidade complementar para o tratamento da UPD, avaliando sua segurança e efeitos adversos. Materiais: estudo observacional. O PRP foi aplicado a 6 pacientes com UPD crônica, Wagner II, III, com um atraso médio na cicatrização de 94 semanas. Foi administrado por punção e como gel sobre a lesão uma vez por semana até o fechamento da úlcera ou por 12 semanas. As UPD foram analisadas em relação à área e sua progressão, utilizando o software de análise de imagem de úlcera Mobile Wound Analyzer (MOWA). A redução percentual da área foi calculada entre a medição inicial e a semana 12. Como critério de melhora, optou-se pela redução > 70% da lesão. Resultados: predominou o sexo masculino com média de idade de 53 ± 7,3 anos. Após 12 semanas de tratamento, foi relatada uma redução média no tamanho da úlcera de 78%, sendo 2 com cicatrização completa e 2 em 99%. Um paciente foi amputado após desenvolver infecção descontrolada. Conclusão: a aplicação do PRP melhorou a regeneração tecidual, encurtando o tempo de duração da úlcera, promovendo sua cicatrização sem efeitos adversos, ao mesmo tempo que eliminava a necessidade de procedimentos de manejo na úlcera crônica.


Subject(s)
Diabetic Foot/therapy , Platelet-Rich Plasma , Foot Ulcer/therapy
2.
Medicina (B.Aires) ; 81(2): 297-300, June 2021. graf
Article in English | LILACS | ID: biblio-1287285

ABSTRACT

Abstract Contact electrical burns are more severe than other forms of contact burn injury. Moreover, treatment of hand burns is an important therapeutic challenge. We present a 17 year-old female of low voltage electric hand injury, admitted 5 days after injury. The patient was treated with autologous platelet rich plasma, porcine dermis heterograft and partial autologous skin graft, all of them with hyperbaric oxygen therapy (HBOT) at 1.45 ATA ≈100% O2 like adjuvant therapy. Good evolution and acceptable aesthetic results were reported. Although more studies are required, we suggest that multi-therapeutic approach could be effective in treatment for electric burns in hands.


Resumen Las quemaduras eléctricas por contacto son más graves que otras formas de quemaduras. Además, el tratamiento de las mismas en las manos es un importante desafío terapéutico. Presentamos el caso de una mujer de 17 años de edad con lesión en la mano por quemadura por electricidad de baja tensión. Fue ingresada 5 días después de la lesión y tratada con plasma rico en plaquetas autólogo, heteroinjerto de dermis porcina e injerto de piel autólogo parcial, todo con oxigenoterapia hiperbárica (TOHB) a 1.45 ATA ≈100% O2 como terapia adyuvante. Tuvo buena evolución y resultados estéticos aceptables. Aunque se requieren más estudios, sugerimos que el enfoque multi-terapéutico podría ser eficaz en el tratamiento de las quemaduras eléctricas en las manos.


Subject(s)
Humans , Animals , Female , Adolescent , Burns/therapy , Burns, Electric/therapy , Platelet-Rich Plasma , Hyperbaric Oxygenation , Swine , Skin Transplantation
3.
Arq. gastroenterol ; 58(2): 185-189, Apr.-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1285312

ABSTRACT

ABSTRACT BACKGROUND: Surgical treatment of recurrent anal fistulas can lead to numerous complications, including fecal incontinence. Therefore, sphincter preserving techniques are gaining more popularity. OBJECTIVE: The aim of the study was to assess effectiveness of platelet-rich plasma (PRP) therapy in the patients with recurrent cryptoglandular anal fistulas. METHODS: A cohort of 18 patients with anal fistulas was enrolled into a preliminary and prospective trial. They were divided into two groups consisting of eight and ten patients respectively. PRP was injected locally in all patients, however in the group II it was applied after 7 days drainage of fistulas with polyurethane foam or negative pressure wound therapy. On average, three doses of PRP were administered, but with the opportunity to double the number of applications if it was clinically justified. The patients were evaluated in an out-patient department after fortnight and then in 1, 6, and 12 months following the last PRP application. RESULTS: Anal fistulas were closed in 4 (50%) patients from the group I and in 7 (70%) patients form the group II. Although, the difference between both groups was not statistically significant, PRP therapy should be preceded with fistulous tract drainage in all patients. Summarizing, that successful result was achieved in 11 (60%) patients from the entire group of 18 participants. CONCLUSION: The rate of recurrent cryptoglandular anal fistulas closure reaching 60%, after topical treatment with PRP, exceeds the results of other sphincter-saving methods of treatment. Therefore, it might become a novel method of anal fistulas therapy.


RESUMO CONTEXTO: O tratamento cirúrgico de fístulas anais recorrentes pode levar a inúmeras complicações, incluindo incontinência fecal. Portanto, as técnicas de preservação do esfíncter estão ganhando mais popularidade. OBJETIVO: O objetivo do estudo foi avaliar a eficácia da terapia de plasma rico em plaquetas (PRP) nos pacientes com fístulas anais criptoglandulares recorrentes. MÉTODOS: Uma coorte de 18 pacientes com fístulas anais foi inscrita em ensaio preliminar e prospectivo. Eles foram divididos em dois grupos compostos por 8 e 10 pacientes, respectivamente. PRP foi injetado localmente em todos os pacientes, porém no grupo II foi aplicado espuma de poliuretano ou terapia de feridas por pressão negativa após 7 dias de drenagem de fístulas. Em média, foram administradas três doses de PRP, mas com a oportunidade de dobrar o número de aplicações se fosse clinicamente justificado. Os pacientes foram avaliados em ambulatório após quinze dias e depois em 1, 6 e 12 meses após a última aplicação do PRP. RESULTADOS: As fístulas anais foram fechadas em 4 (50%) pacientes do grupo I e em 7 (70%) pacientes do grupo II. Embora a diferença entre ambos os grupos não tenha sido estatisticamente significante, a terapia PRP deve ser precedida de drenagem do trato fístulo em todos os pacientes. Resumindo, esse resultado bem-sucedido foi alcançado em 11 (60%) pacientes de todo o grupo de 18 participantes. CONCLUSÃO: A taxa de fechamento recorrente de fístulas anais criptoglandulares chegando a 60%, após tratamento tópico com PRP, excede os resultados de outros métodos de tratamento que preservam o esfíncter. Portanto, pode se tornar um novo método de terapia das fístulas anais.


Subject(s)
Humans , Rectal Fistula , Platelet-Rich Plasma , Fecal Incontinence , Anal Canal , Prospective Studies , Treatment Outcome
4.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 605-612, May-June 2021. tab, ilus
Article in English | ID: biblio-1278352

ABSTRACT

The high prevalence of exercise-induced pulmonary hemorrhage (EIPH) in athletic horses constitutes to be a challenge to the racing industry and a source of major concern to animal welfare. Both experimental and clinical evidence indicate that the use of autologous platelet-rich plasma (PRP) is a promising effector of repair in a variety of pulmonary conditions. The present study evaluated the effect of intrabronchial instillation of PRP on EIPH endoscopic scores from 37 Thoroughbred racehorses. Inclusion criteria were for animals to be EIPH-positive in, at least, two consecutive post-exercise endoscopic exams and to receive 250mg of furosemide IV four hours before racing. Animals were randomly assigned into 3 groups: placebo, control, and PRP instillation. All 37 Thoroughbred racehorses included had EIPH endoscopic scores pre- and post- treatment compared by statistical analysis. The bleeding score from the group receiving PRP was significantly lower than in the control and placebo groups. No adverse effects were observed in any animal during or after the experiment. It was possible to conclude that the intrabronchial instillation of autologous PRP was effective in reducing EIPH scores in racehorses receiving furosemide and that this bioproduct can be considered as a promising coadjuvant in controlling EIPH in athletic horses.(AU)


A alta prevalência de hemorragia pulmonar induzida por exercício (HPIE) em cavalos atletas é um desafio de longa data para a indústria de corridas, além de figurar como grande preocupação sobre o bem-estar animal. As evidências experimentais e clínicas indicam que o uso do plasma rico em plaquetas (PRP) de fonte autógena é promissor na terapêutica de diversas lesões pulmonares. O presente estudo objetivou avaliar as mudanças após corrida no escore endoscópico de HPIE de 37 cavalos Puro-Sangue Inglês que receberam instilação intrabronquial de PRP autólogo. Os animais selecionados eram HPIE-positivos em, ao menos, dois exames endoscópicos consecutivos e recebiam 250mg de furosemida IV administrado quatro horas antes de cada corrida. Na comparação dos escores endoscópicos pré e pós-tratamento, verificou-se que o escore de HPIE do grupo tratado com PRP foi significantemente menor que o dos grupos controle e placebo. Nenhum efeito adverso foi observado nos animais durante ou após o experimento. Concluiu-se que a instilação intrabronquial de PRP autólogo foi efetiva na redução do escore de HPIE de cavalos de corrida usuários de furosemida e que este bioproduto pode ser considerado uma alternativa promissora no controle de HPIE em cavalos atletas.(AU)


Subject(s)
Animals , Physical Conditioning, Animal/adverse effects , Platelet-Rich Plasma , Acute Lung Injury/veterinary , Horses/physiology , Instillation, Drug , Furosemide/analysis , Hemorrhage/veterinary
5.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 613-621, May-June 2021. tab, ilus
Article in English | ID: biblio-1278361

ABSTRACT

The objective in this study was to evaluate the clinic effect of applying allogenic platelet-rich plasma (PRP) heated or not, for treating cornea ulcers, including the dosage of PDGF-BB in the cornea. The ulcers were induced, standardizing the left eye from 81 rats (Ratus norvegicus, albinus variety), assigned randomly into three groups (N=27): control group (CG) which did not receive any topic treatment; heated PRP group (GA) and PRP group (GP), which received topical treatment every eight hours for five days. Each group underwent evaluation at 24 hours (M1), three days (M3) and five days (M5). The clinical exam evaluated the opacity, vascularization and corneal repair. The corneal PDGF-BB was dosed through the ELISA method. The corneal opacity was decreased in PRP-treated animals (GA and GP) and corneal repair time reduced when compared to CG at M1 and M5. Furthermore, GP showed greater vascularization at M3 compared to M1. Applied allogenic PRP eye drops, heated or not, speed up corneal healing, and reduce corneal repair time. However, the corneal PDGF concentration was not altered in any of the treatments.(AU)


Objetivou-se avaliar o efeito clínico da aplicação de plasma rico em plaquetas alogênico (PRP) aquecido ou não, no tratamento de úlceras de córnea, como a dosagem de PDGF-BB na córnea. As úlceras foram induzidas, padronizando-se o olho esquerdo de 81 ratos (Rattus norvegicus, variedade albinus), aleatoriamente, nos três grupos (N = 27): grupo controle (CG), que não recebeu nenhum tratamento tópico; grupo PRP aquecido (GA) e grupo PRP (GP), que receberam tratamento tópico a cada oito horas, durante cinco dias. Cada grupo foi subdividido em 24 horas (M1), três dias (M3) e cinco dias (M5). O exame clínico avaliou a opacidade, a vascularização e o reparo corneano. O PDGF-BB corneano foi dosado pelo método Elisa. Houve diminuição da opacidade da córnea nos animais tratados com PRP (GA e GP) e diminuição do tempo de reparo da córnea em comparação com CG, M1 e M5. Além disso, foi observada maior vascularização no GP no momento M3 em relação ao M1. A aplicação de colírios de PRP alogênico, aquecidos ou não, acelera a cicatrização da córnea, além de reduzir o tempo de reparo da córnea. No entanto, a concentração de PDGF na córnea não se alterou em nenhum dos tratamentos.(AU)


Subject(s)
Animals , Rats , Ophthalmic Solutions/therapeutic use , Platelet-Derived Growth Factor/analysis , Corneal Ulcer/chemically induced , Platelet-Rich Plasma , Enzyme-Linked Immunosorbent Assay/veterinary , Animals, Laboratory
6.
Medisan ; 25(2)mar.-abr. 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1250340

ABSTRACT

Introducción: El uso de plasma rico en plaquetas para la regeneración de defectos óseos periodontales constituye una terapéutica eficaz. Objetivo: Identificar la evolución de pacientes con lesiones endoperiodontales tratados con plasma rico en plaquetas. Métodos: Se realizó un estudio observacional, descriptivo y longitudinal de 11 adultos con enfermedad endoperiodontal y tratamiento endodóntico finalizado, atendidos en la consulta de Periodoncia y Medicina Regenerativa del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, desde febrero del 2018 hasta diciembre del 2019, quienes requerían intervención quirúrgica periodontal y cumplían los criterios para recibir plasma rico en plaquetas. A tal efecto, se analizaron variables sociodemográficas, clínicas, radiográficas y de respuesta terapéutica, las que fueron expresadas estadísticamente por medio de frecuencias absolutas y relativas y de la media aritmética. Resultados: En la serie resultaron más frecuentes, antes de la terapia, el sangrado al sondaje (81,8 %), las características alteradas de las encías (72,7 %), la movilidad dentaria (72,7 %) y las bolsas periodontales de 7 a 9 milímetros, con pérdida ósea en el tercio apical (63,6 %); todo lo cual se revirtió a menores porcentajes luego de 6 meses de tratamiento. Conclusiones: La evolución de los pacientes afectados por lesiones periodontales fue satisfactoria con el empleo del plasma rico en plaquetas, lo que se evidenció clínica y radiográficamente.


Introduction: The use of platelets rich-plasm for the regeneration of periodontal bony defects constitutes an effective therapy. Objective: To identify the clinical course of patients with endoperiodontal lesions treated with platelets rich-plasm. Methods: An observational, descriptive and longitudinal study of 11 adults with endoperiodontal disease and concluded endodontics treatment was carried out. They were assisted in the Periodontics and Regenerative Medicine Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, from February, 2018 to December, 2019; who required periodontal surgical intervention and fulfilled the approaches to receive platelets rich-plasm. To such an effect, sociodemographic, clinical, radiographic and of therapeutic response variables were analyzed, which were statistically expressed by means of absolute and relative frequencies and of mean arithmetic. Results: In the series, bleeding on probing (81.8 %), altered characteristics of the gums (72.7 %), dental mobility (72.7 %) and 7 to 9 millimeters periodontal bags, with bony loss in the third apical (63.6 %) were more frequent before therapy; all of which was reverted to lower percentages after 6 months of treatment. Conclusions: The clinical course of the patients affected by periodontal lesions was satisfactory with the use of platelets rich-plasm, which was clinical and radiographically evidenced.


Subject(s)
Periodontal Diseases/therapy , Bone Regeneration , Platelet-Rich Plasma , Periodontics , Adult , Endodontics , Prolotherapy
7.
Rev. cuba. anestesiol. reanim ; 20(1): e683, ene.-abr. 2021.
Article in Spanish | LILACS, CUMED | ID: biblio-1156368

ABSTRACT

Introducción: La enfermedad degenerativa discal es una entidad frecuente y uno de los principales motivos de consulta. Genera altas tasas de discapacidad, años útiles perdidos, así como altos costos económicos por asistencia médica y grandes pérdidas monetarias. Su tratamiento es generalmente conservador, aunque en la actualidad se incluyen terapias biológicas novedosas. Objetivo: Describir las principales propiedades biológicas que hacen del plasma rico en plaquetas una terapéutica efectiva para la enfermedad degenerativa discal. Métodos: Se realizó una revisión no sistemática de la bibliografía basada en artículos que se publicaron en bases de datos indexadas en Infomed como Hinari, Ebsco, Scielo, Pubmed, Cubmed, Cocrhane, Scopus, LILACS; en idioma español, inglés y portugués, durante los últimos diez años. Desarrollo: Se expusieron características clínico epidemiológicas de la enfermedad degenerativa discal, así como las propiedades biológicas que le permiten al plasma rico en plaqueta tener una función activa en la regeneración del disco intervertebral o el retraso de la cascada de degradación de este. Se resaltan los principales estudios de acuerdo a la vía de administración del plasma rico en plaquetas y sus resultados. Conclusiones: De acuerdo con lo publicado por los autores, el plasma rico en plaquetas es una alternativa efectiva en el tratamiento de la enfermedad degenerativa discal por la producción de factores derivados de las plaquetas, que intervienen en la degeneración del disco intervertebral, siendo la vía intradiscal la que más se emplea(AU)


Introduction: Degenerative disc disease is a frequent condition and one of the main reasons to attend the consultation. It generates high rates of disability, useful years lost, as well as high economic costs for medical assistance and large monetary losses. Its treatment is generally conservative, although novel biological therapies are currently included. Objective: To describe the main biological properties that make platelet-rich plasma an effective therapy against degenerative disc disease. Methods: A nonsystematic review of the bibliography was carried out based on articles published, during the last ten years, in databases indexed in Infomed, such as Hinari, Ebsco, Scielo, Pubmed, Cubmed, Cocrhane, Scopus, and LILACS, in Spanish, English and Portuguese. Development: Clinical-epidemiological characteristics of degenerative disc disease were presented, as well as the biological properties that allow platelet-rich plasma to have an active function in the regeneration of the intervertebral disc or the delay of its degradation cascade. The main studies are highlighted, according to the route of administration of platelet-rich plasma and their results. Conclusions: According to what has been published by authors, platelet-rich plasma is an effective alternative in the treatment of degenerative disc disease, due to the production of factors derived from platelets, which intervene in the degeneration of the intervertebral disc, being the intradiscal pathway the most used(AU)


Subject(s)
Humans , Platelet-Rich Plasma/physiology , Intervertebral Disc Degeneration/therapy , Intervertebral Disc Degeneration/epidemiology , Intervertebral Disc Degeneration/surgery
8.
Int. braz. j. urol ; 47(2): 287-294, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1154463

ABSTRACT

ABSTRACT Purpose: Despite high success rates in the treatment of urinary incontinence, complications related to the use of polypropylene (PP) meshes are still a concern, especially in vaginal prolapses surgeries. The objective of this study was to assess the effect of autologous platelet-rich plasma (PRP) coating on the integration of PP meshes implanted in the vaginal submucosa of rabbits. Materials and Methods: Thirty adult New Zealand rabbits were randomly divided into two groups (n=15): PP, implanted with conventional PP meshes; and PRP, implanted with autologous PRP coated PP meshes. Animals in both groups (n=5) were euthanized at 7, 30 and 90 days postoperatively, the vaginas extracted and sent to immunohistochemical analysis for the assessment of the pro-inflammatory agent TNF-α, anti-inflammatory agents TGF-β and IL-13, collagen metabolism marker MMP-2, and angiogenesis marker CD-31. AxioVision™ image analysis was used for the calculation of the immunoreactive area and density. Statistical analysis was performed with ANOVA followed by Tukey test (p <0.05). Results: Animals in the PRP group showed significantly increased expression of the angiogenesis agent CD-31 at all experimental times when compared to the PP group (p <0.0001). However, no differences concerning the expression of the other markers were observed between the groups. Conclusion: The addition of autologous PRP gel to PP meshes can be simply and safely achieved and seems to have a positive effect on implantation site angiogenesis. Further investigations are required to ascertain PPR coated meshes clinical efficacy in prolapses and stress urinary incontinence surgeries.


Subject(s)
Animals , Female , Polypropylenes , Platelet-Rich Plasma , Rabbits , Surgical Mesh , Vagina/surgery , Collagen
10.
Braz. j. med. biol. res ; 54(2): e9944, 2021. tab, graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1142581

ABSTRACT

The aim of this study was to inhibit adipogenic differentiation by transfecting two growth factors, platelet-derived growth factor (PDGF-BB) and bone morphogenic protein 2 (BMP-2), into modified rat bone marrow mesenchymal stem cells (rBMSCs) and then compounded with platelet-rich plasma (PRP). To achieve rBMSCs, the osteoporosis model of rats was established, and then the rBMSCs from the rats were isolated and identified. Co-transfection of rBMSCs with PDGF-BB-GFP and BMP-2 and detection of PDGF-BB/BMP-2 expression in transfected BMSCs was assessed by qRT-PCR and western blot, respectively. Moreover, the effect of the two growth factors transfection of rBMSCs on adipogenic differentiation was evaluated by oil red O staining and western blot, respectively. Finally, construction of the two growth factors transfection of rBMSCs compounded with PRP and detection of adipogenic differentiation were assessed by oil red O staining, CCK-8, and western blot, respectively. In vitro studies revealed that the two growth factors transfection of rBMSCs compounded with PRP promoted cell viability and inhibited adipogenic differentiation and could be promising for inhibiting adipogenic differentiation.


Subject(s)
Animals , Rats , Cell Differentiation , Adipose Tissue/cytology , Platelet-Rich Plasma , Bone Morphogenetic Protein 2/genetics , Mesenchymal Stem Cells/cytology , Becaplermin/genetics , Transfection , Cells, Cultured
11.
Rev. Hosp. Clin. Univ. Chile ; 32(1): 4-16, 2021. tab, ilus, graf
Article in Spanish | LILACS | ID: biblio-1252505

ABSTRACT

Platelet rich plasma (PRP) is used to speed up tissue repair. Despite its widespread use, the therapeutic application of PRP generates controversies in clinical results due to the variability in methods of obtaining the different preparations and differences between the components of different types of PRP, so it's recommended to mention the type of platelet preparation used. In this article, we describe technical and biologics characteristics of our platelet product, and we compare them to different commercial preparations described in order to validate their clinical use. Our results determine that the preparation can be considered a platelet rich plasma with biological activity in vivo and in vitro, which supports its use as a valid therapeutic tool, alternative to products currently available in Regenerative Medicine. (AU)


Subject(s)
Humans , Regenerative Medicine/trends , Platelet-Rich Plasma , Cell- and Tissue-Based Therapy
12.
Med. lab ; 25(1): 419-440, 2021. tabs
Article in Spanish | LILACS | ID: biblio-1292915

ABSTRACT

Introducción. El empleo del plasma rico en plaquetas (PRP) o plasma autólogo con una cifra de plaquetas superior a la del plasma basal, ha tomado un auge notorio para estimular la regeneración tisular en las afecciones musculoesqueléticas y de tejidos blandos. El objetivo de este estudio fue revisar sistemáticamente la eficacia del tratamiento con PRP en algunas lesiones musculoesqueléticas y de tejidos blandos en cirugía plástica y maxilofacial, así como en odontología y dermatología, con su nivel de evidencia y grado de recomendación. Metodología. Se utilizaron los buscadores PubMed, Google Académico y la Biblioteca Cochrane con terminología MeSH. Se analizaron un total de 44 artículos que cumplieron los criterios de inclusión y exclusión. Resultados. El análisis de los estudios encontró que el nivel de evidencia fue de 1 en el 75%, nivel 2 en el 15,9%, nivel 3 en el 6,8%, y nivel 4 en el 2,2%. El grado de recomendación se distribuyó entre bueno y favorable; el 40,9% de los estudios reflejaron grado A, 50% grado B y 9% grado C. No obstante, el 50% de los estudios reportaron en sus conclusiones que hay una deficiencia en el diseño metodológico, con inconsistencia en sus resultados. Conclusión. Estos hallazgos señalan que en la evidencia encontrada se observan resultados contradictorios, la mayoría de ellos no muestran una prueba firme que apoye el empleo rutinario del PRP, porque sus diseños y poder estadístico son de baja calidad. Hace falta unificar criterios y diseños de investigación con evidencia científica altamente recomendable, para que el uso del PRP como agente ortobiológico en estas patologías, pueda ser ampliamente aceptado


Introduction. The use of platelet-rich plasma (PRP), autologous plasma with a number of platelets higher than that of basal plasma, after having been subjected to some extraction and concentration process, has taken a noticeable rise to stimulate tissue regeneration in musculoskeletal and soft tissue disorders. The objective of this study is to systematically review the efficacy of treatment with PRP in some musculoskeletal and soft tissue injuries, in plastic and maxillofacial surgery, as well as in dentistry and dermatology, with their level of evidence and grade of recommendation. Methodology. The search was performed using MeSH terms in PubMed, Google Scholar and the Cochrane Library. A total of 44 articles that met the inclusion and exclusion criteria were analyzed. Results. Analysis of the studies found that the level of evidence was level 1 in 75%, level 2 in 15.9%, level 3 in 6.8%, and level 4 in 2.2%. The grade of recommendation was distributed between good and favorable; 40.9% reflected grade A, 50% grade B, and 9% grade C. However, 50% of the studies reported in their conclusions that there is a deficiency in the methodology, with inconsistency in their results. Conclusion. These findings indicate that the evidence found shows contradictory results, most of them do not show a firm proof that supports their routine use, because their designs and statistical power are of low quality. It is necessary to unify criteria and research designs with highly recommended scientific evidence, so that the use of PRP as an orthobiological agent in these pathologies could be widely accepted


Subject(s)
Humans , Platelet-Rich Plasma , Osteoarthritis , Surgery, Oral , Surgery, Plastic , Musculoskeletal Diseases , Dermatology
13.
Braz. dent. sci ; 24(3): 1-7, 2021. ilus
Article in English | LILACS, BBO | ID: biblio-1281929

ABSTRACT

Objective: To test the ability of platelet-rich plasma clinically and radiologically for pulp regeneration of immature teeth with apical periodontitis. Material and Methods: An experimental study was conducted From (March/2018-July/2020) 12 upper central immature incisors with acute apical periodontitis and necrotic pulp from six patients receiving regenerative endodontic treatment using concentrated platelets rich plasma were performed by the same endodontist at Mediclinic Middle East Hospitals. Informed consent, including explanation of risks and alternative treatments or no treatment were prepared and filled by the patient parents. The therapeutic protocol was involved accessing the pulp chamber; irrigation copiously with sodium hypochlorite; applying calcium hydroxide as intracanal medicament and a provisionally sealing it after 4 weeks. The canal was cleaned, dried and injected with concentrated platelets rich plasma which serve as a scaffold for pulp regeneration. MTA was used to seal the chamber before final filling with composite. Evaluations: All teeth were monitored clinically (mobility, palpation, percussion, and sensitivity cold test) and radiographically. Results: Twenty months follow-up all teeth showed resolution of periapical radiolucencies, continued root development with positive response to sensitivity cold test and no discoloration. Conclusion: The results of this study confirmed the previous finding that pulp regeneration can be gained by using cPRP successfully. (AU)


Objetivo: Testar a capacidade do plasma rico em plaquetas clinicamente e radiograficamente para a regeneração pulpar em dentes imaturos com periodontite apical. Material e Métodos: O estudo experimental foi realizado em Março/2018 e Julho/2020, 12 incisivos centrais imaturos com periodontite apical aguda e necrose pulpar em 6 pacientes recebendo tratamento endodôntico regenerativo usando concentrado de plasma ricas em plaquetas. Foram realizadas pelo mesmo endodontista no Hospital Mediclinic Middle East. O consentimento informado incluindo explicação do risco e tratamentos alternativos ou de nenhum tratamento foi preenchido pelos responsáveis do paciente. O protocolo terapêutico envolveu acesso à câmara pulpar, irrigação abundante com hipoclorito de sódio, aplicação de hidróxido de cálcio como medicação intracanal e selado intracanal por 4 semanas. O canal foi limpo, seco e injetado concentrado de plasma rico em plaquetas que servem como um scaffold para a regeneração pulpar. Usou-se MTA para selar a câmara antes do preenchimento final com compósitos. Avaliações: Todos os dentes foram monitorados clinicamente (mobilidade, palpação, percussão e teste de sensibilidade com frio) e radiograficamente. Resultados: Após 20 meses de acompanhamento, todos os dentes apresentaram a resolução das radioluscências periapicais, desenvolvimento contínuo da raiz com resposta positiva ao teste de sensibilidade ao frio e sem descoloração. Conclusão: O resultado do estudo confirmou descobertas anteriores que a regeneração pulpar pode ser obtida usando cPRP com sucesso. (AU)


Subject(s)
Humans , Periodontitis , Bone Regeneration , Platelet-Rich Plasma
14.
Clinics ; 76: e2355, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153933

ABSTRACT

OBJECTIVES: To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients. METHODS: A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel. RESULTS: The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05). CONCLUSION: In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.


Subject(s)
Humans , Pressure Ulcer , Platelet-Rich Plasma , Negative-Pressure Wound Therapy , Quality of Life , Wound Healing
15.
Artrosc. (B. Aires) ; 28(1): 81-86, 2021.
Article in Spanish | LILACS, BINACIS | ID: biblio-1252455

ABSTRACT

Introducción: El objetivo del siguiente estudio fue evaluar la influencia de la edad, el sexo, el índice de masa corporal y el hemograma previo de los pacientes en la composición final del PRP. Materiales y métodos: Se realizó un análisis multivariado en trescientos pacientes para determinar la relación entre las mencionadas variables. Resultados: el número de plaquetas finales mostró una relación directa con las plaquetas basales (F (9.187) = 2.067, p = 0.034). Cuando las plaquetas basales aumentaron en una unidad, las plaquetas finales aumentan en promedio con un intervalo de valores de 0.236 a 4.618 (IC 95%, p = 0.00752). Discusión: el valor esperado medio de leucocitos para el protocolo "bajo" es de 1597 y para el nivel "rico" es de 9253, con un IC 95% se espera que el protocolo "rico" aumente en promedio la cantidad de leucocitos finales entre 280 y 785 % con respecto al protocolo "bajo" (p <0.001). Ninguna de las otras variables estudiadas tuvo una influencia significativa en la composición final del PRP. Conclusión: la cantidad de plaquetas en el hemograma basal afectó significativamente la concentración final de plaquetas en el PRP. Además, el protocolo de preparación afectó la concentración final de leucocitos, la que fue significativamente mayor en el protocolo de PRP rico en leucocitos que en el protocolo pobre en leucocitos. El sexo, el IMC y el HTO previo no influyeron significativamente en las concentraciones finales de plaquetas ni de leucocitos del PRP final. Nivel de Evidencia: IV


Introduction: The purpose of this study study was to evaluate the influence of age, sex, body mass index and previous blood count of patients on the final composition of the PRP. Material and methods: a multivariate analysis was performed in three hundred patients to determine the relationship between sex, age, body mass index (BMI) and the characteristics of the baseline blood count with the final composition of the PRP. Results: the number of final platelets showed a direct relationship with the basal platelets (F (9.187) = 2.067, p = 0.034). When the basal platelets increased by one unit, the final platelets increased on average with a range of values from 0.236 to 4.618 (95% CI, p = 0.00752).Discussion: the mean expected value of leukocytes for the "low" protocol is 1597 and for the "rich" level it was 9253, with a 95% CI the "rich" protocol is expected to increase on average the amount of final leukocytes between 280 and 785 % with respect to the "low" protocol (p <0.001). None of the other variables studied had a significant influence on the final composition of the PRP. Conclusion: the amount of platelets in the basal blood count significantly affected the final concentration of platelets in the PRP. Likewise, the preparation protocol affected the final leukocyte concentration, being the same significantly higher in the leukocyte-rich PRP protocol than in the leukocyte-poor protocol. Sex, BMI and previous HTO did not significantly influence the final platelet or leukocyte concentrations of the final PRP. Level of Evidence: IV


Subject(s)
Blood Cell Count , Body Mass Index , Musculoskeletal Diseases , Platelet-Rich Plasma
17.
Pesqui. vet. bras ; 41: e06999, 2021. tab, ilus
Article in English | ID: biblio-1351280

ABSTRACT

Platelet-rich plasma (PRP) has been considered a promising therapeutic alternative, since platelets are rich in growth factors that are used in the Regenerative Medicine field. However, fresh PRP cannot be stored for long periods. This study aimed to develop a protocol for obtaining lyophilized canine PRP capable of maintaining viability after its reconstitution. For that purpose, canine PRP extraction and lyophilization protocols were initially tested. Subsequently, assays were carried out to quantify the growth factors VEGF and TGF-β, before and after the lyophilization process, gelation test and the three-dimensional gel structure analysis of the reconstituted lyophilized PRP by electron microscopy, as well as in vitro cell proliferation test in lyophilized PRP gel. Additionally, the immunogenicity test was performed, using allogeneic samples of lyophilized PRP. The results showed that the lyophilized PRP had adequate therapeutic concentrations of growth factors VEGF and TGF-β (9.1pg/mL and 6161.6pg/mL, respectively). The reconstituted PRP gel after lyophilization showed an in vitro durability of 10 days. Its electron microscopy structure was similar to that of fresh PRP. In the cell proliferation test, an intense division process was verified in mesenchymal stem cells (MSCs) through the three-dimensional mesh structure of the lyophilized PRP gel. The immunogenicity test showed no evidence of an immune reaction. The findings were promising, suggesting the possibility of having a lyophilized canine PRP that can be marketed. New in vivo and in vitro studies must be carried out for therapeutic confirmation.(AU)


O plasma rico em plaquetas (PRP) é uma alternativa terapêutica promissora, pois as plaquetas são ricas em fatores de crescimento com ação na regeneração de tecidos. No entanto, o PRP fresco não pode ser armazenado por longos períodos. Esse trabalho teve como objetivo desenvolver um protocolo de obtenção de PRP liofilizado canino capaz de manter a viabilidade pós reconstituição. Portanto, foram testados diversos protocolos de extração e liofilização. Para validação do PRP canino liofilizado foi analisada a concentração dos fatores de crescimento VEGF e TGF-β antes e após o processo de liofilização, a estrutura tridimensional do PRP liofilizado reconstituído em forma de gel por microscopia eletrônica e seu efeito in vitro na proliferação de células-tronco mesenquimais. Os resultados demonstraram que o PRP liofilizado apresentou concentrações terapêuticas adequadas dos fatores de crescimento VEGF e TGF- β (9,1pg/ml e 6161,6pg/ml, respectivamente). O gel de PRP reconstituído após liofilização apresentou uma durabilidade in vitro de 10 dias, sua estrutura tridimensional mostrou-se semelhante ao PRP fresco e proporcionou intensa proliferação de células-tronco mesenquimais durante o cultivo. O teste de imunogenicidade não demonstrou evidências de reação imune. Os achados foram promissores, sugerindo a possibilidade de uso de PRP canino liofilizado para o mercado. Novos estudos in vivo e in vitro deverão ser conduzidos para comprovação terapêutica.(AU)


Subject(s)
Animals , Dogs , In Vitro Techniques , Platelet-Rich Plasma , Mesenchymal Stem Cells , Freeze Drying , Therapeutics , Dogs
18.
Cienc. tecnol. salud ; 7(3): 442-460, 26 de noviembre 2020. ^c27 cmilus
Article in Spanish | LILACS, LIGCSA, DIGIUSAC | ID: biblio-1141473

ABSTRACT

En las últimas décadas, la terapia de plasma rico en plaquetas (PRP) ha despertado mucha atención en el área de la medicina regenerativa, siendo aplicada a diferentes patologías sistémicas y localizadas. El PRP proporciona diversos factores de crecimiento y proteínas que pueden estimular al proceso de regeneración celular, representa un factor importante para su uso clínico generalizado, en diferentes tejidos en donde el suministro de sangre es lento o limitado y apoya la recuperación, cicatrización, activación biológica de células de defensa, estabilización en la regeneración celular y tisular, teniendo uso clínico en casi todas las especialidades médicas. Esta revisión tiene como objetivo presentar las bases teóricas para la potencial aplicación del PRP y sus factores de crecimiento en tratamientos que buscan una terapia regenerativa por bioestimulación de la aplicación autóloga, en patologías para las cuales aún no existe tratamiento específico. Se revisaron artículos de los últimos 10 años en los buscadores y bases de datos Google Scholar, PubMed y Scopus y se seleccionaron aquellos que pueden ayudar a entender la aplicación de PRP en diversos procesos de regeneración, con miras a utilizarse como un tratamiento alternativo y complementario a pacientes con COVID-19. Se encontró abundante literatura experimental y clínica en el uso de PRP autóloga, en diversos procesos de regeneración, inclusive en neumología e infectología, por lo que amerita comprobar su efecto con protocolos establecidos, en patologías respiratorias severas como apoyo biológico autólogo para activar la respuesta biológica innata de tipo celular.


Platelet-rich plasma (PRP) therapy has generated much attention in recent decades in regenerative medicine, being applied to different systemic and localized pathologies. PRP provides various growth factors and proteins that can stimulate the cell regeneration process. It is an important factor for its clinical use in different tissues where blood supply is slow or limited, and supports the recovery, healing, activation of defense cells, cellular stabilization, and tissue regeneration, having clinical use in almost all medical specialties. Articles from the last 10 years in Google Scholar, PubMed and Scopus were reviewed and selected those that can help to understand the application of PRP in various regeneration processes, with a view to use as an alternative and complementary treatment for patients with Covid-19. It was found that there is abundant experimental and clinical literature on the use of autologous PRP in various regeneration processes, including pneumology and infectious diseases. It worth evaluating its effect in severe respiratory diseases as an autologous biological support to activate the innate cellular response.


Subject(s)
Humans , Therapeutics , Regenerative Medicine , Platelet-Rich Plasma , Pulmonary Medicine , Communicable Diseases , Coronavirus Infections
19.
Arq. Ciênc. Vet. Zool. UNIPAR (Online) ; 23(2, cont.): e2312, jul-dez. 2020. ilus
Article in Portuguese | ID: biblio-1141382

ABSTRACT

A não união óssea é uma complicação ortopédica que ocorre normalmente devido à instabilidade da fratura em decorrência de uma escolha de fixação inadequada ou inapropriada, suprimento sanguíneo deficiente, osteomielite e afastamento excessivo dos fragmentos; sendo mais comumente em cães de raças pequenas e miniatura; e de maior ocorrência em regiões distais de rádio, ulna, tíbia e fíbula. Este trabalho relata a utilização da associação entre Hidroxiapatita e Plasma Rico em Plaqueta no tratamento de uma não união óssea de rádio e ulna e esclarece os benefícios desses biomateriais no processo de regeneração do tecido ósseo. O presente trabalho tem por objetivo relatar o caso de um canino com não união óssea de rádio/ulna devido ao alinhamento inadequado dos fragmentos ósseos no tratamento conservador com bandagem, proporcionando instabilidade do foco da fratura. O tratamento cirúrgico consistiu na colocação de uma placa óssea e enxertia com Hidroxiapatita e Plasma Rico em Plaqueta para melhor regeneração óssea. A utilização de tais biomateriais no tratamento da não união foi benéfica para a formação do calo ósseo primário, não produzindo efeitos adversos para o paciente. A partir desse resultado pode-se concluir que, a utilização desses biomateriais e enxertia precisa ser mais bem estudada e aprimorada na reparação óssea de uma não união, visto que, a aplicabilidade dessa associação mostrou-se um método eficiente, não apresentando sinais de infecção e nem evidência de rejeição.(AU)


Bone nonunion is an orthopedic complication that usually occurs due to fracture instability as a result of an inadequate or inappropriate choice of fixation, deficient blood supply, osteomyelitis, and excessive removal of fragments; which is more commonly seen in small and miniature breeds; and more frequent in the distal regions of radius, ulna, tibia, and fibula. This paper reports on the use of the association between Hydroxyapatite and Platelet-Rich Plasma in the treatment of a radius and ulna nonunion and clarifies the benefits of these biomaterials in the bone tissue regeneration process. This study reports the case of a dog presenting nonunion of radius and ulna bone due to inadequate alignment of bone fragments in a conservative treatment with bandage, providing instability of the fracture focus. The surgical treatment consisted of placing a bone plate and grafting with Hydroxyapatite and Platelet-Rich Plasma for better bone regeneration. The use of such biomaterials in the treatment of nonunion injuries was beneficial for the formation of the primary bone callus, without producing adverse effects for the patient. From this result, it can be concluded that the use of these biomaterials and grafting needs to be further studied and improved for use in bone repair of nonunion cases, since the applicability of this association proved to be an efficient method, with no signs of infection or evidence of rejection.(AU)


Ausencia de unión ósea es uma complicación ortopédica que normalmente ocurre debido a la instabilidade de la fractura como resultado de uma elección de fijación inadecuada o inapropriada, aporte sanguíneo deficiente, osteomielitis y remoción excessiva de fragmentos; que se observa com mayor frecuencia en perros de razas pequeñas y miniaturas; y más frecuente em regiones distales de radio, cúbito, tíbia y peroné. Este artículo informa sobre el uso de la asociación de Hidroxiapatita y Plasma rico en plaqueta en el tratamiento de ausencia de unión del radio e el cúbito, y aclara los benefícios de esos biomateriales en el processo de regeneración del tejido ósseo. Esa investigación ha tenido como objetivo reportar el caso de un perro sin unión de radio / cúbito por alineación inadecuada de fragmentos óseos en tratamiento conservador con vendaje, proporcionando inestabilidad del foco de la fractura. El tratamiento quirúrgico consistió en la colocación de una placa ósea e injerto con Hidroxiapatita y Plasma rico en plaqueta para uma mejor regeneración ósea. El uso de tales biomateriales en el tratamiento de ausencia de unión ha sido beneficioso para la formación del callo óseo primario, sin producir efectos adversos para el paciente. A partir de ese resultado se puede concluir que, el uso de esos biomateriales e injertos necesitan ser mejor estudiado y mejorado en la reparación de ausencia ósea, ya que la aplicabilidad de esa asociación demostró ser um método eficaz, sin presentar signos de infección y evidencia de rechazo.(AU)


Subject(s)
Animals , Dogs , Bone Regeneration , Dogs/injuries , Fractures, Bone , Platelet-Rich Plasma , Methods , Orthopedics
20.
Rev. bras. ortop ; 55(5): 551-556, Sept.-Oct. 2020. tab, graf
Article in English | LILACS | ID: biblio-1144208

ABSTRACT

Abstract Objectives This study aimed to analyze the efficacy of platelet-rich plasma obtained from the peripheral, autologous blood of the patients in pain complaints reduction and functional improvement of knee osteoarthritis compared with the standard treatment with injectable corticosteroid, such as triamcinolone. Methods The patients were followed-up clinically at the preinfiltrative visit, with quantitative evaluation using the Knee Society Score (KSS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and the Kellgren and Lawrence scales. In addition, they were reevaluated with the same scales after 1 month and 6 months of intervention with 2.5 mL of triamcinolone acetate or 5 mL of platelet-rich plasma. The study was performed on 50 patients with knee osteoarthritis treated at the Medical Specialty Center and randomly divided into equivalent samples for each therapy. Results The present study verified the reduction of pain scores, such as the WOMAC score, and elevations of functional scales, such as the KSS, evidenced in 180 days when using platelet-rich plasma, a therapy that uses the autologous blood of the patient and has fewer side effects. Conclusion Although both platelet-rich plasma and corticosteroid therapies have been shown to be effective in the reduction pain complaints and functional recovery, there was a statistically significant difference between them at 180 days. According to the results obtained, platelet-rich plasma presented longer-lasting effects within 180 days in the treatment of knee osteoarthritis.


Resumo Objetivo Analisar a eficácia do uso de plasma rico em plaquetas, obtido do sangue periférico e autólogo dos pacientes, na redução das queixas álgicas e melhoria funcional dos pacientes portadores de osteoartrite de joelhos, em comparação com o tratamento padrão com injeção de corticosteroides de depósito, como a triancilonola. Métodos Os pacientes foram acompanhados clinicamente na consulta pré-infiltrativa, com avaliação quantitativa através das escalas Knee Society Score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), e Kellgren and Lawrence. Além disso, os pacientes foram reavaliados com as mesmas escalas após 1 mês e 6 meses de intervenção com 2,5 mL de acetato de triancinolona ou 5 mL de plasma rico em plaquetas. O estudo foi feito em 50 pacientes portadores de osteoartrite de joelhos atendidos no Centro de Especialidades Médicas, divididos em amostras equivalentes randomizadas para cada terapia. Resultados No presente estudo, verificaram-se redução dos valores em escalas álgicas, como a WOMAC, e elevação das pontuações em escalas funcionais, como a KSS, evidenciadas em 180 dias após o uso de plasma rico em plaquetas, uma terapia feita a partir do sangue autólogo do paciente e com menos efeitos colaterais. Conclusão Embora ambas as terapias com plasma rico em plaquetas e corticosteroides tenham se mostrado eficazes na redução das queixas álgicas e na recuperação funcional, houve diferença significativa entre as terapias aos 180 dias. De acordo com os resultados obtidos, no tratamento da osteoartrite do joelho, o plasma rico em plaquetas demonstrou efeitos mais duradouros em 180 dias.


Subject(s)
Humans , Osteoarthritis , Blood , Triamcinolone , Efficacy , Adrenal Cortex Hormones , Osteoarthritis, Knee , Platelet-Rich Plasma , Recycling , Injections
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