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2.
Arch. argent. pediatr ; 118(3): 193-201, jun. 2020. tab, ilus
Article in English, Spanish | LILACS (Americas), BINACIS | ID: biblio-1104196

ABSTRACT

Introducción. La infección respiratoria aguda baja por adenovirus es una importante causa de morbimortalidad en niños. Objetivos: Describir el patrón clínico-epidemiológico y los factores asociados en niños hospitalizados.Métodos. Estudio transversal en niños ingresados por infección respiratoria aguda baja al Hospital de Niños Ricardo Gutiérrez, Buenos Aires, en 2000-2018. El diagnóstico viral se realizó mediante inmunofluorescencia indirecta en secreciones nasofaríngeas. Se compararon características clínico-epidemiológicas de infección por adenovirus con otros virus respiratorios (virus sincicial respiratorio, influenza y parainfluenza). Se utilizó regresión logística múltiple para identificar predictores independientes de infección.Resultados. De 16018 pacientes con infección respiratoria aguda baja, 13545 fueron testeados para virus respiratorios y 6047 (el 45 %) fueron positivos. Adenovirus fue el agente menos frecuente [el 4,4 % (265) de los casos]; presentó una tendencia en descenso durante todo el período estudiado (pico en 2003) y circuló durante todo el año (pico en julio). El 63,8 % eran varones; mediana de edad: 11 meses (rango intercuartílico: 6-20). La presentación clínica más frecuente fue neumonía (el 63 %). El 50 % tenía internaciones previas por causa respiratoria; el 15,6 % eran reingresos; el 58,3 % tenía comorbilidades. El 19,2 % requirió asistencia ventilatoria; el 44 %registró complicaciones. La letalidad fue del 7,7 %. La infección por adenovirus se asoció a edad ≥ 12 meses, sexo masculino, presentación clínica de neumonía, internaciones previas por causas respiratorias y reinternaciones.Conclusiones. Los adenovirus fueron detectados con menor frecuencia que los otros virus respiratorios, aunque presentaron un importante perfil de morbimortalidad


Introduction. Acute lower respiratory tract infection (ALRTI) caused by adenovirus is a major cause of morbidity and mortality in children.Objectives. To describe the clinical and epidemiological pattern and associated factors in hospitalized children.Methods. Cross-sectional study in children admitted due to ALRTI to Hospital de Niños "Ricardo Gutiérrez," in the Autonomous City of Buenos Aires, between 2000 and 2018. Viral diagnosis was done by indirect immunofluorescence in nasopharyngeal secretions. The clinical and epidemiological characteristics of adenovirus infection were compared to other respiratory viruses (respiratory syncytial virus, influenza, and parainfluenza). A multiple logistic regression was done to identify independent predictors of infection.Results. Out of 16 018 patients with ALRTI, 13 545 were tested for respiratory viruses; 6047 (45 %) had a positive result. Adenovirus was the least common agent (4.4 % [265] of cases); it tended towards a reduction over the study period (peak in 2003) and circulated throughout the year (peak in July). In total, 63.8 % of patients were males; median age: 11 months (interquartile range: 6-20). The most common clinical presentation was pneumonia (63 %). Prior admissions due to respiratory conditions were seen in 50 %; 15.6 %were readmissions; 58.3 % had comorbidities. Ventilatory support was required by 19.2 %and complications were recorded in 44 %. The fatality rate was 7.7 %. Adenovirus infection was associated with age ≥ 12 months, male sex, clinical presentation of pneumonia, prior admissions due to respiratory conditions, and readmissions.Conclusions. Adenoviruses were less common than other respiratory viruses, although their morbidity and mortality were important


Subject(s)
Humans , Male , Female , Infant , Respiratory Tract Infections/epidemiology , Adenoviridae Infections/epidemiology , Pneumonia , Respiratory Tract Infections/virology , Epidemiologic Studies , Child, Hospitalized , Cross-Sectional Studies , Adenoviridae Infections/diagnosis , Fluorescent Antibody Technique, Indirect
3.
Arch. argent. pediatr ; 118(3): e305-e308, jun. 2020. tab
Article in Spanish | LILACS (Americas), BINACIS | ID: biblio-1116994

ABSTRACT

El síndrome urémico hemolítico asociado a Streptococcus pneumoniae (SUH-Sp) se define como anemia hemolítica microangiopática, plaquetopenia y lesión renal aguda, en un paciente con infección invasiva por Streptococcus pneumoniae (Sp). Varón de 2 años, con neumonía con derrame pleural por Sp aislado en hemocultivos y líquido pleural. A las 72 h, presentó palidez, decaimiento, quejido respiratorio y oliguria. En el análisis de laboratorio se encontró anemia, plaquetopenia, aumento de la urea, la creatinina y la lactato deshidrogenasa en sangre; coombs directa +; esquistocitos en frotis; fibrinógeno; coagulograma normal; dímero D aumentado. Orina con proteinuria y hematuria. En Terapia Intensiva requirió asistencia respiratoria mecánica y transfusión con glóbulos rojos lavados; se recuperó progresivamente. El Instituto Malbrán informó serotipo 38 de Sp. Es el primer paciente comunicado con este serotipo


Streptococcus pneumoniae associated hemolytic uremic syndrome (Sp-HUS) is defined as microangiopathic hemolytic anemia, thrombocytopenia and acute renal injury, in a patient with Streptococcus pneumoniae (Sp) invasive infection. A 2-year-old boy was admitted with pneumonia and empyema. Sp was isolated from blood and pleural fluid cultures. After 72 h, the patient showed paleness, asthenia, respiratory whining and oliguria. Laboratory showed anemia, low platelets, increased blood urea, creatirnina, lactate dehdrogenase, direct Coombs +, schistocytes, fibrinogen, normal coagulogram and increased D-dimer. Proteinuria and hematuria were detected in urine. Mechanical ventilatory assistance and transfusions of washed red blood cells were required. The patient recovered progressively. Sp serotype 38 was isolated in the National Reference Laboratory "Malbran". This is the first report associated to this serotype


Subject(s)
Humans , Male , Child, Preschool , Hemolytic-Uremic Syndrome , Pneumonia , Respiratory Insufficiency , Streptococcus pneumoniae , Renal Insufficiency , Anemia, Hemolytic
4.
Rev. argent. mastología ; 39(142): 5-11, jun. 2020.
Article in Spanish | LILACS (Americas) | ID: biblio-1104075

ABSTRACT

El 12 de diciembre de 2019 el mundo era rutinariamente normal y, muy escuetamente, las noticias mencionaban algunos casos de una rara neumonía viral observados en Wuhan, Provincia de Hubei, China. Entre el 30 de diciembre y el 3 de enero de 2020, todo drásticamente cambió. Se denunció, primero en un chat, una rara epidemia y, posteriormente, fue desmentida en un documento por quien la denunció, el oftalmólogo chino Li Weliang, bajo coacción del gobierno de su país "acusándolo de difundir rumores falsos". Dos días después, la Organización Mundial de la Salud (oms) alertó sobre un brote de neumonía de etiología desconocida en Wuhan; y recién el 7 de enero las autoridades chinas comunican que han identificado un nuevo virus causante de la nueva enfermedad: el 2019-nCoV


Subject(s)
Pneumonia , Pneumonia, Viral , Therapeutics , Breast Neoplasms , Coronavirus Infections , Epidemics
5.
Article in English | WPRIM (Western Pacific) | ID: wprim-816681

ABSTRACT

OBJECTIVE: This study presents a preliminary report on the chest radiographic and computed tomography (CT) findings of the 2019 novel coronavirus disease (COVID-19) pneumonia in Korea.MATERIALS AND METHODS: As part of a multi-institutional collaboration coordinated by the Korean Society of Thoracic Radiology, we collected nine patients with COVID-19 infections who had undergone chest radiography and CT scans. We analyzed the radiographic and CT findings of COVID-19 pneumonia at baseline. Fisher's exact test was used to compare CT findings depending on the shape of pulmonary lesions.RESULTS: Three of the nine patients (33.3%) had parenchymal abnormalities detected by chest radiography, and most of the abnormalities were peripheral consolidations. Chest CT images showed bilateral involvement in eight of the nine patients, and a unilobar reversed halo sign in the other patient. In total, 77 pulmonary lesions were found, including patchy lesions (39%), large confluent lesions (13%), and small nodular lesions (48%). The peripheral and posterior lung fields were involved in 78% and 67% of the lesions, respectively. The lesions were typically ill-defined and were composed of mixed ground-glass opacities and consolidation or pure ground-glass opacities. Patchy to confluent lesions were primarily distributed in the lower lobes (p = 0.040) and along the pleura (p < 0.001), whereas nodular lesions were primarily distributed along the bronchovascular bundles (p = 0.006).CONCLUSION: COVID-19 pneumonia in Korea primarily manifested as pure to mixed ground-glass opacities with a patchy to confluent or nodular shape in the bilateral peripheral posterior lungs. A considerable proportion of patients with COVID-19 pneumonia had normal chest radiographs.


Subject(s)
Cooperative Behavior , Coronavirus , Humans , Korea , Lung , Pleura , Pneumonia , Radiography , Radiography, Thoracic , Thorax , Tomography, X-Ray Computed
6.
Article in English | WPRIM (Western Pacific) | ID: wprim-816680

ABSTRACT

From December 2019, Coronavirus disease 2019 (COVID-19) pneumonia (formerly known as the 2019 novel Coronavirus [2019-nCoV]) broke out in Wuhan, China. In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. She was diagnosed with COVID-19 infection confirmed by real-time reverse-transcriptase-polymerase chain reaction. CT showed rapidly progressing peripheral consolidations and ground-glass opacities in both lungs. After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions.


Subject(s)
Adult , China , Coronavirus , Fatigue , Female , Fever , Humans , Lung , Pneumonia , Thorax , Tomography, X-Ray Computed
7.
Article in English | WPRIM (Western Pacific) | ID: wprim-816604

ABSTRACT

BACKGROUND: The weather has well-documented effects on infectious disease and reports suggest that summer peaks in the incidences of gram-negative bacterial infections among hospitalized patients. We evaluated how season and temperature changes affect bloodstream infection (BSI) incidences of major pathogens to understand BSI trends with an emphasis on acquisition sites.METHODS: Incidence rates of BSIs by Staphylococcus aureus, Enterococcus spp., Escherichia coli, Klebsiella pneumoniae, Acinetobacter spp., and Pseudomonas aeruginosa were retrospectively analyzed from blood cultures during 2008–2016 at a university hospital in Seoul, Korea according to the acquisition sites. Warm months (June–September) had an average temperature of ≥20℃ and cold months (December–February) had an average temperature of ≤5℃.RESULTS: We analyzed 18,047 cases, where 43% were with community-onset BSI. E. coli (N = 5,365) was the most common pathogen, followed by Enterococcus spp. (N = 3,980), S. aureus (N = 3,075), K. pneumoniae (N = 3,043), Acinetobacter spp. (N = 1,657), and P. aeruginosa (N = 927). The incidence of hospital-acquired BSI by Enterococcus spp. was weakly correlated with temperature, and the median incidence was higher during cold months. The incidence of community-onset BSI by E. coli was higher in warm months and was weakly correlated with temperature.CONCLUSION: We found seasonal or temperature-associated variation in some species-associated BSIs. This could be a useful information for enhancing infection control and public health policies by taking season or climate into consideration.


Subject(s)
Acinetobacter , Climate , Climate Change , Communicable Diseases , Enterococcus , Escherichia coli , Gram-Negative Bacterial Infections , Humans , Incidence , Infection Control , Klebsiella pneumoniae , Korea , Pneumonia , Pseudomonas aeruginosa , Public Health , Retrospective Studies , Seasons , Seoul , Staphylococcus aureus , Tertiary Care Centers , Weather
8.
Article in English | WPRIM (Western Pacific) | ID: wprim-782500

ABSTRACT

In December 2019, a viral pneumonia outbreak caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV), began in Wuhan, China. We report the epidemiological and clinical features of the first patient with 2019-nCoV pneumonia imported into Korea from Wuhan. This report suggests that in the early phase of 2019-nCoV pneumonia, chest radiography would miss patients with pneumonia and highlights taking travel history is of paramount importance for early detection and isolation of 2019-nCoV cases.


Subject(s)
China , Coronavirus , Humans , Korea , Pneumonia , Pneumonia, Viral , Radiography , Thorax
9.
Article in English | WPRIM (Western Pacific) | ID: wprim-782489

ABSTRACT

BACKGROUND: The purposes of this study were 1) to investigate the incidence of pneumonia during hospitalization in elderly hip fracture patients, 2) to evaluate the effect of pneumonia on 30 day to 1 year mortality and 3) to analyze the impact of age and gender on the mortality rate in the pneumonia patients using a nationwide cohort of Korea.METHODS: The Korean National Health Insurance Service (NHIS) database included approximately 5.5 million Korean enrollees > 60 years of age. A total of 588,147 participants were randomly selected for senior cohort using 10% simple random sampling. We identified senile (> 65 years old) patients who underwent hip fracture surgery from January 2005 to December 2014 and those who developed pneumonia during hospitalization from the NHIS-Senior cohort. The index date of hip fracture occurrence was defined as the date of admission to the acute care hospital. The last date of follow-up was defined as the date of death or 31 December 2015, whichever came first. A multivariable-adjusted Cox proportional hazards model was used to investigate the effects of pneumonia on all-cause mortality.RESULTS: During the enrollment period, a total of 14,736 patients, who were older than 65 years, underwent hip fracture surgeries. Among them, 1,629 patients (11.05%) developed pneumonia during the hospitalization. The pneumonia incidence was 16.39% (601/3,666) in men patients and 9.29% (1,028/10,042) in women patients. Compared to 13,107 non-pneumonia patients, adjusted relative risk (aRR) of death in pneumonia patients was 2.69 (95% confidence interval [CI], 2.14–3.38; P < 0.001) within postoperative 30-day, 3.40 (95% CI, 3.01–3.83; P < 0.001) within postoperative 90-day, 2.86 (95% CI, 2.61–3.15; P < 0.001) within postoperative 180-day and 2.31 (95% CI, 2.14–2.50; P < 0.001) within postoperative 1-year. According to patient's age, the aRR of death in pneumonia patients was 5.75 (95% CI, 2.89–11.43) in adults aged < 70 years, 5.14 (95% CI, 4.08–6.46) in those aged 70–79 years, 3.29 (95% CI, 2.81–3.86) in those aged 80–89 years and 2.02 (95% CI, 1.52–2.69) in those aged ≥ 90 years. The aRR was 3.63 (95% CI, 3.01–4.38) in men pneumonia patients, and 3.27 (95% CI, 2.80–3.83) in women pneumonia patients.CONCLUSION: The prevalence of pneumonia in elderly hip fracture patients was 11.05%. Men had higher incidence (16.39%) than women (9.29%). Compared to non-pneumonia patients, the pneumonia patients had higher 30-day to 1-year mortalities with aRR of 2.31 to 3.40. They had increased mortality in all age groups older than 65 years with aRR of 1.52 to 4.08. Both genders of pneumonia patients had higher risk of mortality (aRR, 3.63 in men and 3.27 in women) compared to non-pneumonia patients.


Subject(s)
Adult , Aged , Cohort Studies , Female , Follow-Up Studies , Hip , Hospitalization , Humans , Incidence , Korea , Male , Mortality , National Health Programs , Pneumonia , Prevalence , Proportional Hazards Models
10.
Article in English | WPRIM (Western Pacific) | ID: wprim-782485

ABSTRACT

BACKGROUND: Hypervirulent Klebsiella pneumoniae (hvKP) has been the most significant pathogen for liver abscesses in East Asia including the Republic of Korea (ROK). Although gastrointestinal colonization of K. pneumoniae may cross the intestinal barrier to invade the liver, characteristics of gastrointestinal carriage K. pneumoniae of hvKP liver abscess patients in the ROK are not well known.METHODS: Characteristics of K. pneumoniae isolated from stool samples and liver aspirate samples of patients with hvKP liver abscess at a tertiary care hospital in the ROK between 2017 and 2018 were evaluated.RESULTS: Out of 37 patients with hvKP liver abscess, 11 patients were noted to have K. pneumoniae isolated from stool samples and were enrolled for analysis. The median age was 71 years. For hvKP isolates from the liver aspirate samples, the most common serotype was K1 (72.7%) followed by K2 (27.3%). For K. pneumoniae isolates from the stool sample, the majority was non-K1/K2 serotype (72.7%). Among non-K1/K2 serotype isolates, high variability of sequence type (ST; ST15, ST307, ST37, ST273, ST2622, and ST42) with high rate of presence of extended-spectrum beta-lactamase (100.0%) was noted. The concordance rate of the K. pneumoniae isolates between the liver aspirate samples and the stool samples from the primary hvKP liver abscess was low (27.3%).CONCLUSION: This study suggests that significant heterogeneity of K. pneumoniae colonizing intestinal tract of the hvKP liver abscess patients. Further studies involving a larger number of hvKP liver abscess patients with continuing surveillance are needed to define the changing epidemiology and the role of gastrointestinal K. pneumoniae in the hvKP liver abscess patients in the ROK.


Subject(s)
beta-Lactamases , Colon , Epidemiology , Far East , Humans , Klebsiella pneumoniae , Klebsiella , Liver Abscess , Liver , Pneumonia , Population Characteristics , Republic of Korea , Serogroup , Tertiary Healthcare
11.
Article in English | WPRIM (Western Pacific) | ID: wprim-782219

ABSTRACT

BACKGROUND: Use of appropriate antibiotics for the treatment of pneumonia is integral in patients admitted to intensive care units (ICUs). Although it is recommended that empirical treatment regimens should be based on the local distribution of pathogens in patients with suspected hospital-acquired pneumonia, few studies observe patients admitted to ICUs with nursing home–acquired pneumonia (NHAP). We found factors associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via the emergency room (ER).METHODS: We performed a retrospective cohort study of 83 pneumonia patients with confirmed causative bacteria admitted to ICUs via ER March 2015–May 2017. We compared clinical parameters, between patients who received appropriate or inappropriate antibiotics using the Mann-Whitney U, Pearson's chi-square, and Fisher's exact tests. We investigated independent factors associated with inappropriate antibiotic use in patients using multivariate logistic regression.RESULTS: Among 83 patients, 30 patients (36.1%) received inappropriate antibiotics. NHAP patients were more frequently treated with inappropriate antibiotics than with appropriate antibiotics (47.2% vs. 96.7%, p<0.001). Methicillin-resistant Staphylococcus aureus was more frequently isolated from individuals in the inappropriate antibiotics–treated group than in the appropriate antibiotics–treated group (7.5% vs. 70.0%, p<0.001). In multivariate analysis, NHAP was independently associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via ER.CONCLUSION: NHAP is a risk factor associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via the ER.


Subject(s)
Anti-Bacterial Agents , Bacteria , Cohort Studies , Critical Care , Emergency Service, Hospital , Hospitals, Teaching , Humans , Intensive Care Units , Logistic Models , Methicillin-Resistant Staphylococcus aureus , Multivariate Analysis , Nursing , Pneumonia , Retrospective Studies , Risk Factors
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-811125

ABSTRACT

BACKGROUND: The number of patients with systemic lupus erythematosus (herein, lupus) undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) is increasing. There is disagreement about the effect of lupus on perioperative complication rates. We hypothesized that lupus would be associated with higher complication rates in patients who undergo elective primary THA or TKA.METHODS: Records of more than 6.2 million patients from the National Inpatient Sample who underwent elective primary THA or TKA from 2000 to 2009 were reviewed. Patients with lupus (n = 38,644) were compared with those without lupus (n = 6,173,826). Major complications were death, pulmonary embolism, myocardial infarction, stroke, pneumonia, and acute renal failure. Minor complications were wound infection, seroma, deep vein thrombosis, hip dislocation, wound dehiscence, and hematoma. Patient age, sex, duration of hospital stay, and number of Elixhauser comorbidities were assessed for both groups. Multivariate logistic regression models using comorbidities, age, and sex as covariates were used to assess the association of lupus with major and minor perioperative complications. The alpha level was set to 0.001.RESULTS: Among patients who underwent THA, those with lupus were younger (mean age, 56 vs. 65 years), were more likely to be women (87% vs. 56%), had longer hospital stays (mean, 4.0 vs. 3.8 days), and had more comorbidities (mean, 2.5 vs. 1.4) than those without lupus (all p < 0.001). In patients with THA, lupus was independently associated with major complications (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1 to 1.7) and minor complications (OR, 1.2; 95% CI, 1.0 to 1.5). Similarly, among patients who underwent TKA, those with lupus were younger (mean, 62 vs. 67 years), were more likely to be women (93% vs. 64%), had longer hospital stays (mean, 3.8 vs. 3.7 days), and had more comorbidities (mean, 2.8 vs. 1.7) than those without lupus (all p < 0.001). However, in TKA patients, lupus was not associated with greater odds of major complications (OR, 1.2; 95% CI, 0.9 to 1.4) or minor complications (OR, 1.1; 95% CI, 0.9 to 1.3).CONCLUSIONS: Lupus is an independent risk factor for major and minor perioperative complications in elective primary THA but not TKA.


Subject(s)
Acute Kidney Injury , Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Comorbidity , Female , Hematoma , Hip Dislocation , Hip , Humans , Inpatients , Knee , Length of Stay , Logistic Models , Lupus Erythematosus, Systemic , Myocardial Infarction , Pneumonia , Pulmonary Embolism , Risk Factors , Seroma , Stroke , Venous Thrombosis , Wound Infection , Wounds and Injuries
13.
Article in English | WPRIM (Western Pacific) | ID: wprim-811069

ABSTRACT

PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have yet to be fully elucidated.METHODS: Microbes in induced sputum samples were subjected to sequence analysis of 16S rRNA. Airway inflammatory phenotypes were defined as neutrophils (>60%) and eosinophils (>3%), and inflammation endotypes were defined by levels of T helper (Th) 1 (interferon-γ), Th2 (interleukin [IL]-5 and IL-13), Th-17 (IL-17), and innate Th2 (IL-25, IL-33, and thymic stromal lymphopoietin) cytokines, inflammasomes (IL-1β), epithelial activation markers (granulocyte-macrophage colony-stimulating factor and IL-8), and Inflammation (IL-6 and tumor necrosis factor-α) cytokines in sputum supernatants was assessed by enzyme-linked immunosorbent assay.RESULTS: The numbers of operational taxonomic units were significantly higher in the mixed (n = 21) and neutrophilic (n = 23) inflammation groups than in the paucigranulocytic inflammation group (n = 19; p < 0.05). At the species level, Granulicatella adiacens, Streptococcus parasanguinis, Streptococcus pneumoniae, Veillonella rogosae, Haemophilus parainfluenzae, and Neisseria perflava levels were significantly higher in the eosinophilic inflammation group (n = 20), whereas JYGU_s levels were significantly higher in the neutrophilic inflammation group compared to the other subtypes (P < 0.05). Additionally, IL-5 and IL-13 concentrations were correlated with the percentage of eosinophils (P < 0.05) and IL-13 levels were positively correlated with the read counts of Porphyromonas pasteri and V. rogosae (P < 0.05). IL-1β concentrations were correlated with the percentage of neutrophils (P < 0.05). had a tendency to be positively correlated with the read count of JYGU_s (P = 0.095), and was negatively correlated with that of S. pneumoniae (P < 0.05).CONCLUSIONS: Difference of microbial patterns in airways may induce distinctive endotypes of asthma, which is responsible for the neutrophilic or eosinophilic inflammation in asthma.


Subject(s)
Asthma , Colony-Stimulating Factors , Cytokines , Enzyme-Linked Immunosorbent Assay , Eosinophils , Haemophilus parainfluenzae , Inflammasomes , Inflammation , Interleukin-13 , Interleukin-33 , Interleukin-5 , Microbiota , Necrosis , Neisseria , Neutrophils , Phenotype , Pneumonia , Porphyromonas , Sequence Analysis , Sputum , Streptococcus , Streptococcus pneumoniae , Veillonella
14.
Article in English | WPRIM (Western Pacific) | ID: wprim-810989

ABSTRACT

No abstract available.


Subject(s)
Coronavirus , Pneumonia , Prognosis
15.
Article in English | WPRIM (Western Pacific) | ID: wprim-810977

ABSTRACT

Since the 2019 novel coronavirus (2019-nCoV or officially named by the World Health Organization as COVID-19) outbreak in Wuhan, Hubei Province, China in 2019, there have been a few reports of its imaging findings. Here, we report two confirmed cases of 2019-nCoV pneumonia with chest computed tomography findings of multiple regions of patchy consolidation and ground-glass opacities in both lungs. These findings were characteristically located along the bronchial bundle or subpleural lungs.


Subject(s)
China , Coronavirus , Lung , Pneumonia , Thorax , World Health Organization
17.
Article in English | WPRIM (Western Pacific) | ID: wprim-810943

ABSTRACT

Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.


Subject(s)
China , Clothing , Commerce , Coronavirus , Fever , Hospitalization , Humans , Korea , Male , Pneumonia , Thorax , Viral Load
18.
Article in English | LILACS (Americas) | ID: biblio-1100242

ABSTRACT

The 2019 novel coronavirus officially named as coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization, has spread to more than 180 countries. The ongoing global pandemic of severe acute respiratory syndrome coronavirus, which causes COVID-19, spread to the United Kingdom (UK) in January 2020. Transmission within the UK was confirmed in February, leading to an epidemic with a rapid increase in cases in March. As on April 25- 2020, there have been 148,377 confirmed cases of COVID-19 in the UK and 20,319 people with confirmed infection have died. Survival of critically ill patients is frequently associated with significant functional impairment and reduced health-related quality of life. Early physiotherapy and community rehabilitation of COVID-19 patients has recently been identified as an essential therapeutic tool and has become a crucial evidence-based component in the management of these patients. This comprehensive narrative review aims to describe recent progress in the application of physiotherapy management in COVID 19 patients. Assessment and evidence- based treatment of these patients should include prevention, reduction of adverse consequences in immobilization, and long-term impairment sequelae. A variety of techniques and modalities of early physiotherapy in intensive care unit are suggested by clinical research. They should be applied according to the stage of the disease, comorbidities, and patient's level of cooperation.


O novo coronavírus de 2019 oficialmente nomeado como pandemia da doença por coronavírus 2019 (COVID-19) pela Organização Mundial de Saúde, se espalhou para mais de 180 países. A pandemia global em curso da síndrome respiratória aguda grave causada pela COVID-19, se espalhou para o Reino Unido em janeiro de 2020. A transmissão no Reino Unido foi confirmada em fevereiro, levando a um rápido aumento de casos em março. Em 25 de abril de 2020, houve 148.377 casos confirmados de COVID-19 no Reino Unido e 20.319 pessoas, com infecção confirmada, morreram. A sobrevivência de pacientes críticos está frequentemente associada ao comprometimento funcional significativo e redução da qualidade de vida relacionada à saúde. A fisioterapia precoce e a reabilitação comunitária de pacientes com COVID-19 foram recentemente identificadas como uma ferramenta terapêutica essencial e tornaram-se um componente crucial baseado em evidências no tratamento desses pacientes. Esta revisão abrangente tem como objetivo descrever o progresso recente na aplicação do manejo da fisioterapia em pacientes com COVID-19. A avaliação e o tratamento baseado em evidências desses pacientes devem incluir a prevenção, a redução de consequências adversas da imobilização e as sequelas de comprometimento a longo prazo. Uma variedade de técnicas e modalidades de fisioterapia precoce em unidade de terapia intensiva são sugeridas por pesquisas clínicas. Eles devem ser aplicados de acordo com o estágio da doença, com as comorbidades e com o nível de cooperação do paciente.


Subject(s)
Coronavirus Infections , Pneumonia , Rehabilitation , Physical Therapy Specialty , Severe Acute Respiratory Syndrome , Medicine
19.
Rev. Ciênc. Plur ; 6(2): 140-155, 2020. tab
Article in Portuguese | LILACS (Americas), BBO | ID: biblio-1100322

ABSTRACT

Introdução:Nas últimas décadas, a qualidade do desenvolvimento e crescimento infantil tem sido utilizada como parâmetro para mensurar a qualidade do desenvolvimento humano e para ter o conhecimento dessa evolução se faz uso dos indicadores de mortalidade e morbidade. Objetivo: Avaliar a morbidade e mortalidade por causas respiratórias em crianças menores de cinco anos de idade no nordeste brasileiro no período de 2013 a 2017.Metodologia:Trata-se de um estudo ecológico, realizado nos estados do nordeste brasileiro utilizando os dados secundários no período de 2013 a 2017. Os dados foram extraídos no Departamento de Informática do Sistema Único de Saúde, através do Sistema de Informação sobre Mortalidade e do Sistema de Informações Hospitalares do Sistema Único de Saúde. Foram usadas as variáveis dependentes: óbitos e adoecimentos hospitalares em crianças de 1 a 4 anos de idade por causas respiratórias e como independentes,o ano e estado do Nordeste brasileiro. Resultados:Foi possível observar a prevalência de óbitos por pneumonia por microrganismo, variando entre 70,04% (470) a 75,66% (569) do total de agravos. Os números referentes a morbidade por pneumonia foram de 60% do total dos casos, seguido de asma com 30%. Conclusões:De acordo com os dados desse estudo é possível concluir a importância da abrangência dos programas de promoção e de prevenção da saúde e a fiscalização na execução delas, pois essas patologias podem ser prevenidas no decorrer do crescimento e desenvolvimento infantil a nível ambulatorial (AU).


Introduction:In the last decades, the quality of child development and growth has been used as aparameter to measure the quality of human development and to have knowledge of this evolution, indicators of mortality and morbidity are used.Objective:To assess morbidity and mortality from respiratory causes in children under five years oldin Northeastern Brazil in the period from 2013 to 2017. Methodology:This is an ecological study carried out in the states of northeastern Brazil using secondary data in period from 2013 to 2017. Data were extracted at the Informatics Department of the Unified Health System, through the Mortality Information System and the Unified Health System Hospital Information System. Dependent variables were used: deaths and hospital illnesses in children from 1 to 4 years of age due to respiratory causes and as independent, the year and state of Northeast Brazil.Results:It was possible to observe the prevalence of deaths due to pneumonia due to microorganisms, ranging from 70.04% (470) to 75.66% (569) of the total of diseases. The figures for pneumonia morbidity were 60% of the total cases, followed by asthma with 30%. Conclusions:According to the data from this study, it is possible to conclude the importance of the comprehensiveness of health promotion and prevention programs and the monitoring of their execution, as these pathologies can be prevented during the growth and development of children at an outpatient level (AU).


Introducción: En las últimas décadas, la calidad del desarrollo y el crecimiento infantil se ha utilizado como parámetro para medir la calidad del desarrollo humano y para tener conocimiento de esta evolución, se utilizan indicadores de mortalidad y morbilidad.Objetivo:Evaluar la morbilidad y la mortalidad por causas respiratorias en niños menores de cinco años en el noreste de Brasil en el período 2013-2017.Metodología: Este es un estudio ecológico realizado en los estados del noreste de Brasil utilizando datos secundarios en período de 2013 a 2017. Los datos se extrajeron en el Departamento de Informática del Sistema Único de Salud, a través del Sistema de Información de Mortalidad y el Sistema de Información Hospitalaria del Sistema Único de Salud. Se utilizaron variables dependientes: muertes y enfermedades hospitalarias en niños de 1 a 4 años debido a causas respiratorias y, de forma independiente, el año y el estado del noreste de Brasil.Resultados:Fue posible observar la prevalencia de muertes por neumonía por microorganismos, que van del 70.04% (470) al 75.66% (569) del total de enfermedades. Las cifras de morbilidad por neumonía fueron del 60% del total de casos, seguidas de asma con el 30%.Conclusiones:Según los datos de este estudio, es posible concluir la importancia de la integralidad delos programas de promoción y prevención de la salud y el monitoreo de su ejecución, ya que estas patologías pueden prevenirse durante el crecimiento y el desarrollo de los niños a nivel ambulatorio (AU).


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Pneumonia , Respiratory Tract Diseases , Brazil/epidemiology , Child , Infant Mortality , Epidemiology , Data Interpretation, Statistical , Ecological Studies
20.
Article in English | AIM (Africa) | ID: afr-201928

ABSTRACT

Background. Pneumonia remains the foremost cause of death in young children in sub-Saharan Africa. This phenomenon is largely driven by poor access to healthcare and delay in seeking medical care for childhood pneumonia. Objective. To assess the effectiveness of training caregivers to recognise the early clinical signs of pneumonia. Methods. The study involved a cohort of women presenting to the Child Welfare Clinic at the Komfo Anokye Teaching Hospital in Kumasi, Ghana, between 7 July and 8 September 2016. A total of 90 women with children younger than 10 weeks were recruited. Participants were trained on identifying early signs of pneumonia using low-cost equipment. Follow-up training and assessment sessions formed part of the programme.Results. At pre-training assessment, the majority of the participants (n=83/90; 92.2%) recognised lower chest indrawing as a sign of respiratory disease requiring immediate hospital intervention. Participants’ performance in determining rhythms of 50 breaths per minute (bpm) and 60 bpm improved significantly across sessions (p=0.011 and p≤0.001, respectively). After training, 87 participants (96.7%) were able to determine rapid breathing accurately compared with 73 participants (81.1%) before training (p=0.001).Conclusion. The results suggest that caregivers can be effectively trained to identify clinical signs of pneumonia in young children, even in low-resource settings. A training initiative as described in this study could be an effective public health intervention to help address the burden of pneumonia in low-resource settings.


Subject(s)
Pneumonia/diagnosis , Caregivers , Infant , Africa
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