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Rev. méd. Minas Gerais ; 31: 31411, 2021.
Article in Portuguese | LILACS | ID: biblio-1291393


A paralisia periódica hipocalêmica tireotóxica é uma complicação rara do hipertireoidismo. Caracteriza-se por episódios de fraqueza muscular recorrente, associado à tireotoxicose e hipocalemia. Ocorre frequentemente em pacientes do sexo masculino e de origem asiática. Nesse contexto, o objetivo deste estudo é descrever o relato de caso de um paciente acometido por paralisia periódica hipocalêmica tireotóxica com redução acentuada da qualidade de vida e internações recorrentes devido a quadro agudo de tetraparesia flácida ascendente associado a hipocalemia grave por não adesão ao tratamento do hipertireoidismo. A paralisia periódica hipocalêmica tireotóxica apresenta evolução favorável quando reconhecida e tratada com controle inicial dos sintomas para normalização sérica do potássio e posterior resolução do quadro tireotóxico.

Thyrotoxic hypokalemic periodic paralysis is a rare complication of hyperthyroidism. The issue has been characterized by episodes of recurrent muscle weakness associated with thyrotoxicosis and hypokalemia. It occurs most often in male patients of Asian origin. This study aims on describing the case report of a patient affected by thyrotoxic hypokalemic periodic paralysis with intense reduction in life quality and recurrent hospitalizations due to ascending acute flaccid tetraparesis associated with severe hypokalemia due to non-adherence to treatment of hyperthyroidism. Thyrotoxic hypokalemic periodic paralysis presents a favorable evolution when identified and treated with initial symptom control for serum potassium normalization and subsequent resolution of the thyroid toxicity.

Humans , Male , Adult , Thyrotoxicosis , Hypokalemic Periodic Paralysis , Potassium , Thyroid Gland , Muscle Weakness , Asian Continental Ancestry Group , Hyperthyroidism , Hypokalemia
Article in English | WPRIM | ID: wpr-921372


OBJECTIVES@#This study aims to explore the effect and molecular mechanism of long non-coding RNA (lncRNA) potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) on proliferation and osteogenic differentiation in human periodontal ligament stem cells (hPDLSCs).@*METHODS@#The hPDLSCs of normal periodontal tissues were isolated and cultured. The mineralized solution induced the osteoblast differentiation of hPDLSCs. The down-regulation of lncRNA KCNQ1OT1, the overexpression of anti-miR-24-3p on the proliferation and the levels of osteocalcin (OCN), osteopontin (OPN) and alkaline phosphatase (ALP) of hPDLSCs were investigated. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the levels of lncRNA KCNQ1OT1, miR-24-3p, OCN, OPN, and ALP. Methyl thiazolyl tetrazolium (MTT) method was used to detect cell viability and activity. Cell proliferation was evaluated by MTT. Western blot was used to detect protein expression. The targeted relationship between lncRNA KCNQ1OT1 and miR-24-3p was detected by double-luciferase experiment.@*RESULTS@#The expression level of lncRNA KCNQ1OT1 increased, and that of miR-24-3p decreased during the osteogenesis of hPDLSCs (@*CONCLUSIONS@#Down-regulation of lncRNA KCNQ1OT1 inhibited the proliferation and osteogenic differentiation of hPDLSCs by targeting the up-regulated expression of miR-24-3p.

Cell Differentiation , Cell Proliferation , Humans , MicroRNAs/genetics , Osteogenesis , Periodontal Ligament/cytology , Potassium , Potassium Channels, Voltage-Gated , RNA, Long Noncoding/genetics , Stem Cells/cytology
Braz. j. biol ; 81(2): 241-245, 2021. tab
Article in English | MEDLINE, LILACS, VETINDEX | ID: biblio-1153370


Pet rabbits have increased their popularity in a lot of countries. However, most of the laboratory profiles in rabbit medicine come from the observations made in rabbit as biomodels or meat production. So that further researches are necessary to obtain reference values for hematology and biochemical profiles in pet rabbits and the different breeds, especially, in relation to acid-base balance. The aim of this report was to offer the mean values of the main parameters connected with acid-base profile in Netherland Dwarf breed. Thirty-five healthy rabbits (15 males and 20 females) were studied. Venous blood sample from lateral saphenous vein was analyzed to measure: haematocrit, haemoglobin, blood urea nitrogen, glucose, blood pH, partial pressure of CO2 (pCO2), total CO2, ions bicarbonate, chloride, sodium, potassium, base excess and anion Gap. Results showed a shorter range that those reported by different researchers. Moreover, differences between genders were showed in pCO2, its values were higher in males. It may be associated with a greater cellular metabolism. Values obtained in this research should be taken into account by veterinary clinicians for this breed in their clinical assessments. Besides, these values provide new results in parameters with few reference values.

A popularidade de coelhos como animais de estimação aumentou em muitos países. No entanto, a maioria dos perfis de laboratório em medicina de coelhos advém das observações de biomodelos animais ou da produção de carne. Assim, são necessárias pesquisas adicionais para obter valores de referência para hematologia e perfis bioquímicos em coelhos de estimação, e das diferentes raças, especialmente, em relação ao equilíbrio ácido-base. O objetivo deste relatório foi oferecer os valores médios dos principais parâmetros ligados ao perfil ácido-base na raça Anã Holandês. Trinta e cinco coelhos saudáveis ​​(15 machos e 20 fêmeas) foram estudados. A amostra de sangue venoso da veia safena lateral foi analisada para mensuração: hematócrito, hemoglobina, nitrogênio ureico sanguíneo, glicose, pH sanguíneo, pressão parcial de CO2 (pCO2), CO2 total, íons bicarbonato, cloreto, sódio, potássio, excesso de base e ânion Gap. Os resultados apresentaram um intervalo menor do que aqueles relatados por diferentes pesquisadores. Além disso, as diferenças entre os gêneros foram mostradas na pCO2, seus valores foram maiores no sexo masculino. Pode estar associado a um maior metabolismo celular. Os valores obtidos nesta pesquisa devem ser levados em consideração pelos clínicos veterinários para esta raça em suas avaliações clínicas. Além disso, esses valores fornecem novos resultados em parâmetros com poucos valores de referencia.

Animals , Male , Female , Rabbits , Potassium/blood , Sodium/blood , Acid-Base Equilibrium , Pets/blood , Reference Values , Blood Specimen Collection/veterinary
J. venom. anim. toxins incl. trop. dis ; 27: e20200164, 2021. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1279407


Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors. There have been reports of a conotoxin acting on two ion channels, but rare reports of a conotoxin acting on three ion channels. Methods Vr3a, a proline-rich M-superfamily conotoxin from a worm-hunting Conus varius, was obtained by solid-phase synthesis and identified by mass spectrometry. The effects of synthesized Vr3a on sodium, potassium and calcium currents were tested on rat DRG cells by patch clamp experiments. The further effects of Vr3a on human Cav1.2 and Cav2.2 currents were tested on HEK293 cells. Results About 10 μM Vr3a has no effects on the peak sodium currents, but can induce a ~10 mV shift in a polarizing direction in the current-voltage relationship. In addition, 10 μM Vr3a can increase 19.61 ± 5.12% of the peak potassium currents and do not induce a shift in the current-voltage relationship. An amount of 10 μM Vr3a can inhibit 31.26% ± 4.53% of the peak calcium currents and do not induce a shift in the current-voltage relationship. The IC50 value of Vr3a on calcium channel currents in rat DRG neurons is 19.28 ± 4.32 μM. Moreover, 10 μM Vr3a can inhibit 15.32% ± 5.41% of the human Cav1.2 currents and 12.86% ± 4.93% of the human Cav2.2 currents. Conclusions Vr3a can simultaneously affect sodium, potassium and calcium currents. This novel triple-target conotoxin Vr3a expands understanding of conotoxin functions.(AU)

Proline/analysis , Conotoxins/analysis , Potassium , Sodium , Calcium
Article in Chinese | WPRIM | ID: wpr-879006


The study aiming at exploring the potassium-dissolving capacity of rhizosphere potassium-dissolving bacteria from diffe-rent sources and screen the strains with high potassium-dissolving ability, so as to lay a theoretical foundation for cultivation and quality improvement of Paris polyphylla var. yunnanensis sources. The rhizosphere soil of 10 wild and transplanted species from Yunnan, Sichuan and Guizhou provinces was used as the research object. Potassium-dissolving bacteria were isolated and purified, and their potassium-dissolving capacity was determined by flame spectrophotometry, and identified by physiological, biochemical and molecular biological methods. Twenty-six potassium-dissolving bacteria were purified and 13 were obtained from wild and transplanted strains respectively. It was found through the determination of potassium-dissolving capacity that the potassium-dissolving capacity of 26 strains was significantly different, and the mass concentration of K~+ in the fermentation broth were 1.04-2.75 mg·L~(-1), the mcentration of potassium were 0.01-1.82 mg·L~(-1). The strains were identified as Bacillus, Agrobacterium rhizome and Staphylococcus by physiological, biochemical and 16 S rDNA molecular methods, among them Bacillus amylolyticus(4 strains) was the dominant bacterium of Bacillus. The physiology and biochemistry of rhizosphere potassium-dissolving bacteria in P. polyphylla var. yunnanensis rhizosphere were diffe-rent, and the living environment were different, so the potassium-dissolving capacity also changed. Strain Y4-1 with the highest potassium decomposability was Bacillus amylolytic with a potassium increase of 1.82 mg·L~(-1). The potassium-dissolving ability and the distribution of potassium-dissolving bacteria were different in various habitats. The screening of potassium-dissolving bacteria provided a new strain for the preparation of microbial fertilizer. It is expected that B. amyloidococcus Y4-1 can be used as an ideal strain to cultivate mycorrhizal seedlings of P. polyphylla var. yunnanensis.

China , Liliaceae , Paenibacillus , Potassium , Rhizosphere , Soil
Chinese Medical Journal ; (24): 539-545, 2021.
Article in English | WPRIM | ID: wpr-878022


BACKGROUND@#The low accuracy of equations predicting 24-h urinary sodium excretion using a single spot urine sample contributed to the misclassification of individual sodium intake levels. The application of single spot urine sample is limited by a lack of representativity of urinary sodium excretion, possibly due to the circadian rhythm in urinary excretion. This study aimed to explore the circadian rhythm, characteristics, and parameters in a healthy young adult Chinese population as a theoretical foundation for developing new approaches.@*METHODS@#Eighty-five participants (mean age 32.4 years) completed the 24-h urine collection by successively collecting each of the single-voided specimens within 24 h. The concentrations of the urinary sodium, potassium, and creatinine for each voided specimen were measured. Cosinor analysis was applied to explore the circadian rhythm of the urinary sodium, potassium, and creatinine excretion. The excretion per hour was computed for analyzing the change over time with repeated-measures analysis of variance and a cubic spline model.@*RESULTS@#The metabolism of urinary sodium, potassium, and creatinine showed different patterns of circadian rhythm, although the urinary sodium excretion showed non-significant parameters in the cosinor model. A significant circadian rhythm of urinary creatinine excretion was observed, while the circadian rhythm of sodium was less significant than that of potassium. The circadian rhythm of urinary sodium and creatinine excretion showed synchronization to some extent, which had a nocturnal peak and fell to the lowest around noon to afternoon. In contrast, the peak of potassium was observed in the morning and dropped to the lowest point in the evening. The hourly urinary excretion followed a similar circadian rhythm.@*CONCLUSION@#It is necessary to consider the circadian rhythm of urinary sodium, potassium, and creatinine excretion in adults while exploring the estimation model for 24-h urinary sodium excretion using spot urine.

Adult , China , Circadian Rhythm , Creatinine , Humans , Potassium , Sodium , Urine Specimen Collection , Young Adult
Article in Chinese | WPRIM | ID: wpr-880455


OBJECTIVE@#To evaluate the capacity of laboratories participated in the proficiency testing (PT) of determination potassium in serum and improve the quality of testing, and put forward technical suggestions for unsatisfied laboratories.@*METHODS@#According to the requirements of CNAS related documents, the homogeneity and stability of the real PT sample were evaluated by one-way ANOVA and t test, respectively. The values of real PT samples were assigned by reference method which was used in PT results assay. It is required that the deviation of value of real PT samples (code:2, 3, 5) between the measured value and the assigned value shall be within ±15.0%. The precision of values for all samples should not be greater than 3.0%.@*RESULTS@#All the laboratories submitted valid data according to the requirements. Only one laboratory did not meet the requirements, and the satisfaction rate was 90.9%.@*CONCLUSIONS@#The ability of most of laboratories are accurate and reliable.

Drinking Water/analysis , Laboratories , Laboratory Proficiency Testing , Potassium
Rev. colomb. gastroenterol ; 35(4): 436-446, dic. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1156326


Resumen Introducción: el cáncer colorrectal es un problema de salud pública; sin embargo, la detección temprana reduce su morbimortalidad. La colonoscopia es el procedimiento de elección para detectar lesiones premalignas y el éxito depende de una limpieza adecuada. El objetivo es evaluar el desempeño de dos preparaciones de bajo volumen empleados en un hospital de alto nivel. Materiales y métodos: estudio prospectivo en adultos que asistieran a colonoscopia en la Fundación Santa Fe de Bogotá, Colombia. Las preparaciones se evaluaron con la escala de Boston, con puntaje ≥ 6 puntos para una limpieza adecuada. Se realizó un análisis de regresión logística para establecer la efectividad de los medicamentos con un cálculo de no inferioridad del 3 %-5 %. Resultados: 598 pacientes fueron evaluados. El 49 % (293) fue expuesto al picosulfato de sodio/citrato de magnesio y el 51 % (305) fue expuesto al sulfato de sodio/potasio/magnesio. Con un promedio de Boston de 6,98 ± 1,86 (78 % con puntaje de Boston ≥ 6) y 7,39 ± 1,83 (83 %), respectivamente (p = 0,649). Según el análisis de la presencia y frecuencia de síntomas no deseados, el picosulfato fue mejor tolerado (p < 0,001). Conclusiones: los estudios de preparación intestinal en pacientes de un escenario real son muy escasos. Los medicamentos de bajo volumen obtuvieron una efectividad global y por segmento de colon similar, confirmando la no-inferioridad; el picosulfato de sodio/citrato de magnesio fue mejor tolerado. Un estudio de costo-efectividad podría definir esto según las necesidades de la población de estudio.

Abstract Introduction: Colorectal cancer is a public health problem; however, early detection reduces morbidity and mortality. Colonoscopy is the procedure of choice for detecting precancerous lesions, and success depends on proper bowel cleansing. Objective: To evaluate the performance of two low-volume agents used in a high-level hospital. Materials and methods: Prospective study in adults who underwent colonoscopy at the Fundación Santa Fe in Bogotá, Colombia. Preparations were evaluated using the Boston Bowel Preparation Scale. A score ≥6 points indicated adequate preparation. A logistic regression analysis was carried out to establish the effectiveness of the medicines with a non-inferiority ratio of 3-5%. Results: 598 patients were evaluated. 49% (293) received sodium picosulfate/magnesium citrate and 51% (305) received sodium sulfate/potassium/magnesium, with an average Boston score of 6.98±1.86 (78% Boston ≥6) and 7.39±1.83 (83%), respectively (p=0.649). According to the analysis of the presence and frequency of unwanted symptoms, picosulfate was better tolerated (p < 0.001). Conclusions: Bowel preparation studies in patients from a real-life scenario are scarce. Low-volume agents had similar overall and segmental effectiveness in the colon, confirming non-inferiority; sodium picosulfate/magnesium citrate was better tolerated. A cost-effectiveness study could establish the best option according to the needs of the study population.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Patients , Pharmaceutical Preparations , Colorectal Neoplasms , Prospective Studies , Colonoscopy , Potassium , Sodium , Effectiveness , Citric Acid , Costs and Cost Analysis , Preparedness , Magnesium
Bol. méd. postgrado ; 36(2): 21-25, dic.2020. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1117893


El síndrome de lisis tumoral (SLT) es una complicación potencialmente letal provocada por la liberación masiva de ácidos nucleicos, potasio y fosfato hacia la circulación sistémica lo cual se asocia a graves trastornos del metabolismo hidroelectrolítico. Se realizó una revisión retrospectiva de historias clínicas con el objetivo de describir las características clínicas de los pacientes con sospecha de SLT que ingresaron al Servicio de Medicina Interna del Hospital General Universitario Dr. Luis Gómez López durante el lapso 2017-2018. El 50% de los pacientes tenían una edad comprendida entre 51 y 70 años, siendo el 65% de sexo femenino. Los canceres más frecuentemente encontrados fueron el cáncer de mama (29%), cáncer gástrico (15%) y el linfoma no Hodgkin (12%). Todos los pacientes presentaron al menos tres de las manifestaciones clínicas asociadas al SLT entre las cuales se encuentran náuseas, vómitos, anorexia, debilidad, calambres, hiperreflexia, oliguria, anuria, hematuria, hipotensión, convulsiones y deshidratación. El 46% de los pacientes presentaron hiperpotasemia, mientras que 36% mostraron hipocalcemia y 18% hiperfosfatemia. El 76% de los pacientes cursaron con una creatinina > 1,4 mg/dl. El diagnóstico definitivo de SLT no fue posible realizarlo en ninguno de los pacientes incluidos en este estudio debido a la falta de estudios paraclínicos necesarios para satisfacer los criterios según los lineamientos internacionales(AU)

Tumor lysis syndrome (TLS) is a potentially lethal complication due to massive release of nucleic acids, potassium and phosphate into the systemic circulation which is associated with severe hydroelectrolitic metabolic disorders. A retrospective review of clinical charts was performed in order to describe clinical characteristics of patients with possible TLS that were admitted to the Servicio de Medicina Interna of the Hospital General Universitario Dr. Luis Gómez López during the period 2017-2018. The results show that 50% of patients were between 51 and 70 years old and 65% were female. Breast cancer (29%), stomach cancer (15%) and Non-Hodgkin lymphoma (12%) were more frequent in patients with possible TLS. All patients showed at least three of the clinical features commonly associated with TLS such as nausea, vomiting, anorexia, weakness, cramps, hyperreflexia, oliguria, anuria, hematuria, hypotension, convulsion and dehydration. 46% of patients had hyperkalemia, 36% hypocalcemia and 18% hyperphosphatemia. Creatinine levels > 1,4 mg/dl were seen in 76% of patients. Definitive diagnosis of TLS was not possible in any of the patients included in this study due to the lack of laboratory studies required according to international guidelines(AU)

Humans , Phosphates , Potassium , Radiotherapy , Breast Neoplasms , Nucleic Acids , Tumor Lysis Syndrome/physiopathology , Drug Therapy , Drug Prescriptions , Critical Care , Hematology , Internal Medicine , Medical Oncology
Biosci. j. (Online) ; 36(6): 1867-1878, 01-11-2020. tab, graf
Article in English | LILACS | ID: biblio-1147948


Nutrient deficiency is a limiting factor in saline-sodic soils resulting in low crop production. The study investigated wheat response to P and K added to soils. The K was applied at 0 (K0), 75 (K1), 150 (K2) kg K2O ha-1 as K2S04 and at (0 (P0), 60 (P1), 120 (P2) kg P2O5 ha-1 as (NH4)2HPO4 in three replications under two-factorial randomized complete block (RCB) design. Both treatments significantly enhanced wheat grain (118%) and dry matter yield (60%) at P2K2 compared to control. The P treatments significantly affected leaf P, Mg, SO4, Ca:P, SO4:P ratios and soil P, Ca:P, Cl:P and SO4:P ratios, while K on leaf K, Na, Ca, SO4 concentration, K:Na, K:Ca, SO4:P,Ca:P ratios and soil pH, Na, K, Ca, SO4 concentrations, SAR, Na:K, Ca:K and Na:Ca ratios. Leaf Na was decreased to 85.3 mmol (+) kg-1 at K2 compared to 105.3 mmol (+) kg-1at P2K0. Negative correlation (R2=0.906) of leaf K:Na was found with leaf Na concentration. The correlation of dry matter was higher (R2=0.851) with leaf K:Na ratio than grain yield (R2=0.392). It is concluded that the addition of K and P addition shows beneficial effects in improving crop nutrition and wheat yield in the saline-sodic soil environment.

A deficiência de nutrientes é um fator limitante em solos salino-sódicos, resultando em baixa produção agrícola. O estudo investigou a resposta do trigo ao P e K adicionados ao solo. O K foi aplicado em 0 (K0), 75 (K1), 150 (K2) kg K2O ha-1 como K2S04 e em (0 (P0), 60 (P1), 120 (P2) kg P2O5 ha-1 como (NH4)2HPO4 em três repetições sob delineamento de blocos completos casualizados (RCB) de dois fatores. Ambos os tratamentos aumentaram significativamente o rendimento de grãos de trigo (118%) e de matéria seca (60%) em P2K2 em comparação com o controle. Os tratamentos com P afetaram significativamente o P foliar, Mg, SO4, as razões Ca:P, SO4:P e o P do solo, e as razões Ca:P, Cl:P e SO4:P, enquanto K no K foliar, Na, Ca, concentração de SO4, razões K:Na, K:Ca, SO4:P, Ca:P e pH do solo, Na, K, Ca, concentrações de SO4, SAR, razões Na:K, Ca:K e Na:Ca. O Na da folha foi reduzido para 85,3 mmol (+) kg-1 em K2 em comparação com 105,3 mmol (+) kg-1 em P2K0. Correlação negativa (R2 = 0,906) do K:Na na folha foi encontrada com a concentração de Na na folha. A correlação da matéria seca foi maior (R2 = 0,851) com a relação K:Na da folha do que rendimento de grãos (R2 = 0,392). Conclui-se que a adição de K e P apresenta efeitos benéficos na melhoria da nutrição da cultura e na produtividade do trigo em solo salino-sódico

Phosphorus , Potassium , Triticum , Soil Acidity , Arid Zone
Biosci. j. (Online) ; 36(5): 1577-1582, 01-09-2020. tab
Article in English | LILACS | ID: biblio-1147812


This study aimed to verify whether inoculation with strains of diazotrophic bacteria, with proven ability to solubilize potassium (K) in vitro, contributes towards the release of K in the soil after fertilization with phonolite rock powder. The experiment was conducted in containers with 0.3 dm-3 of soil containing low potassium content. Fifteen treatments were used, namely, 12 inoculated with the bacterial strains, a control treatment (without phonolite and without inoculation), one containing phonolite without inoculation and one containing KCl, soluble fertilizer, without inoculation. In treatments with phonolite and KCl, the doses of these materials were applied to provide the soil with 195 mg dm-3 of K. A completely randomized design with four replications was used. The soil was incubated during 90 days at room temperature and humidity at about 70% retention capacity. After this period, the content of K+ (Mehlich and resin), pH value and potential acidity (H+Al) were evaluated. Phonolite, associated with inoculation with most bacterial strains, increased the availability of potassium in the soil, pH rate and reduced potential acidity. Among the strains tested, UNIFENAS 100-01, UNIFENAS 100-16, UNIFENAS 100-27, UNIFENAS 100-39 and UNIFENAS 100-93 were the most efficient for the solubilization of K+ of the phonolite. In spite of the observed results, K content released by the bacterial strains in the soil decreased when compared to in vitroconditions, thus justifying the need for studies on bio-solubilization of soil to select the most efficient strains in the process.

O objetivo desse estudo foi avaliar se a inoculação com estirpes de bactérias diazotróficas de comprovada capacidade de solubilizar potássio (K) in vitro, contribui para a liberação de K no solo, após adubação com o pó da rocha fonolito. O experimento foi conduzido em recipientes contendo 0,3 dm-3 de solo contendo baixo teor de potássio. Foram utilizados 15 tratamentos, sendo: 12 com fonolito inoculados com as estirpes bacterianas e 3 tratamentos controle, um sem fonolito e sem inoculação, um contendo fonolito sem inoculação e um contendo KCl, fertilizante solúvel, sem inoculação. Nos tratamentos contendo fonolito e KCl, foi aplicada doses desses materiais para fornecer ao solo 195 mg dm-3 de K. Foi utilizado delineamento inteiramente casualizado com quatro repetições. O solo foi incubado por 90 dias, em temperatura ambiente e a umidade foi mantida a cerca de 70% da capacidade de retenção. Após esse período, foram avaliados o teor de K+ (Mehlich e resina), valor de pH e da acidez potencial (H+Al). A utilização do fonolito, associado a inoculação com a maioria das estirpes bacterianas contribuiu para aumentar a disponibilidade de potássio no solo, o valor de pH e reduzir a acidez potencial. Dentre as estirpes testadas, destacaram-se UNIFENAS 100-01, UNIFENAS 100-16, UNIFENAS 100-27, UNIFENAS 100-39 e UNIFENAS 100-93, que foram as mais eficientes para a solubilização do K+ do fonolito. Apesar dos resultados observados, verificou-se que o teor de K liberado pelas estirpes bacterianas no solo foi reduzido quando comparado às condições in vitro, justificando assim, a necessidade de estudos de biossolubilização no solo visando selecionar as estirpes mais eficientes para desempenhar o processo

Potassium , Soil , Bacteria
Biosci. j. (Online) ; 36(5): 1590-1599, 01-09-2020. tab, ilus
Article in English | LILACS | ID: biblio-1147825


The aim of this study was to identify and categorize new bean cultivars regarding their efficiency and responsiveness to nitrogen, phosphorus, and potassium, both individually and simultaneously, as well as to stipulate the cultivars that would suit each niche market based on this classification. Three experiments were conducted in the field separated by nutrients adopting the randomized block design in a factorial scheme (11 x 4) of 11 cultivars in four doses with three replications. Grain yield was the variable investigated and the means were the basis for the classification separated by in four availabilities: low, partial, adequate dose, and nutritional excess. Genetic variability was observed among the bean cultivars for efficiency and responsiveness (agronomic efficiency) to nitrogen, phosphorus, and potassium. The following cultivars: BRS Agreste, BRS Estilo, BRS Notável, and Pérola revealed the greatest values of efficiency and responsive ratings for nitrogen, phosphorus, and potassium, with indications for low and high technological levels. On the contrary, the cultivars BRS Ametista and BRS Sublime based on the efficiency and non-responsive classification showed a low ability to acquire or utilize the nutrients for grain formation. The BRS Pontal cultivar for all three nutrients displayed a high degree of efficiency with a value exceeding the average under different conditions of stress, suggesting that a more rustic cultivar best suits the market niche of small farmers.

O objetivo do trabalho foi identificar e classificar novas cultivares de feijoeiro quanto a eficiência e responsividade ao nitrogênio, fósforo e potássio, de forma individual e simultânea, além de indicar as cultivares para cada nicho de mercado, de acordo com essa classificação. Foram realizados três experimentos em campo, separados por nutriente, com delineamento de blocos casualizados, em esquema fatorial (11 x 4), sendo 11 cultivares em quatro doses, com três repetições. A variável analisada foi a produtividade de grãos e as médias utilizadas para a classificação, separando-se por nutriente, em quatro disponibilidades, sendo baixo, parcial, dose adequada e excesso nutricional. Existe variabilidade genética para eficiência e responsividade (eficiência agronômica) entre os cultivares de feijão, para nitrogênio, fósforo e potássio. As cultivares BRS Agreste, BRS Estilo, BRS Notável e a Pérola são as que possuem maior número de classificações eficientes e responsivas para nitrogênio, fósforo e potássio, sendo indicadas para baixo e alto nível tecnológico. Em sentido oposto, as cultivares BRS Ametista e a BRS Sublime com classificação ineficiente e não-responsiva, com baixa capacidade de adquirir ou utilizar os nutrientes para a formação de grãos. A cultivar BRS Pontal para nitrogênio, fósforo e potássio, apresenta uma eficiência alta ou acima da média sob os diferentes estresses, o que indica que é uma cultivar mais rústica e que atende o nicho de mercado de pequenos produtores.

Phosphorus , Potassium , Phaseolus , Nitrogen
Biosci. j. (Online) ; 36(4): 1238-1250, 01-06-2020. graf, tab
Article in English | LILACS | ID: biblio-1147237


West Indian cherry stands out among the fruits cultivated for the pharmacological and alimentary importance, but its quality can be affected by irrigation water salinity and fertilization management. In this context, this study aimed to evaluate the effect of irrigation water of different salinities and combinations of nitrogen and potassium fertilization on the physical and physico-chemical quality of bioactive compounds in West Indian cherry fruits. The experiment was carried out in the field, using lysimeters of 60 L, in the Experimental Area of the Centro de Ciências e Tecnologia Agroalimentar (CCTA) of Universidade Federal de Campina Grande (UFCG), Pombal, PB, in a randomized block design, with treatments arranged in a 5 x 4 factorial scheme, referring to five irrigation water salinities (ECw): 0.3, 1.3, 2.3, 3.3 and 4.3 dS m-1 and four combinations (C) of doses of nitrogen (N) and potassium (K2O): C1 = 70% N + 50% K2O; C2 = 100% N + 75% K2O; C3 = 130% N + 100% K2O and C4 = 160% N + 125% K2O, of the recommended dose for West Indiancherry, with three replicates and one plant per plot consisting of a lysimeter. The cv. Flor Branca grafted on cv. Junco was used in the study. The increase in salinity of irrigation water reduced the size, weight and vitamin C content of the fruits, but, the combinations of N and K fertilization did not affect fruit shape and the content of anthocyanin, carotenoids, pH, titratable acidity, total soluble solids and fruit flavor. Fertilization combinations consisting of C1 and C2 treatments promoted the largest fruit size under irrigation with ECw of up to 1.3 dS m-1 and greater mass accumulation. Fertilization doses above C2 combinations negatively affected fruit quality.

A aceroleira se destaca entre as fruteiras cultivadas pela importância farmacológica e alimentícia de seus frutos, porém sua qualidade pode ser afetada pela salinidade da água de irrigação e o manejo da adubação. Neste sentido, objetivou-se com o trabalho estudar o efeito de diferentes salinidades da água de irrigação e de combinações de adubação nitrogenada e potássica sobre a qualidade física, físico-química e de compostos bioativos em frutos de aceroleira. O experimento foi conduzido em campo, usando lisímetros de 60 L, na Área Experimental do Centro de Ciências e Tecnologia Agroalimentar (CCTA) da Universidade Federal de Campina Grande (UFCG), Pombal, PB, em delineamento de blocos ao acaso e esquema fatorial 5 x 4, referentes a cinco níveis de salinidade da água de irrigação (CEa): 0,3; 1,3; 2,3; 3,3 e 4,3 dS m-1 e quatro combinações (C) de adubação nitrogenada e potássica: C1 = 70% N + 50% K2O; C2 = 100% N + 75% K2O; C3 = 130% N + 100% K2O e C4 = 160% N + 125% K2O da dose recomendada para aceroleira, com três repetições e uma planta por parcela constituída de um lisímetro. Estudou-se a cv. Flor Branca enxertada sobre porta-enxerto da cv. Junco, sendo a qualidade dos frutos avaliada entre 260 e 295 dias após o transplantio. O incremento na salinidade da água de irrigação reduziu o tamanho, o peso e o teor de vitamina C nas acerolas, porém, assim como as combinações de adubação de N e K, não afetaram o formato de frutos e os teores de antocianinas, carotenoides, pH, acidez titulável, sólidos solúveis totais e o sabor dos frutos. As combinações de adubação C1 e C2 proporcionaram o maior tamanho de frutos pela irrigação com CEa de até 1,3 dS m-1 e promoveram maior acúmulo de massa. Doses de fertilização acima da combinação C2 afetaram negativamente a qualidade dos frutos mesmo em plantas irrigadas com água de baixa salinidade.

Potassium , Saline Waters , Malpighiaceae , Nitrogen
Biosci. j. (Online) ; 36(3): 761-767, 01-05-2020. ilus, graf, tab
Article in English | LILACS | ID: biblio-1146964


Boron (B) retranslocation may confer greater tolerance to B deficiency or toxicity, resulting in plants and fruits with better nutritional quality. Most plants do not demonstrate phloem mobility for B; however, some plants have natural mobility and others express it under stress conditions, such as nutritional stress. Therefore, we investigated the phloem mobility of B in cherry tomato plants with different nutritional status. The plants were cultivated in nutrient solution with adequate and insufficient doses of Potassium (K) and B. Furthermore, the plants received foliar fertilization with B in a mature leaf (F) in a localized form. The B content and amount in leaves near F were compared with leaves of the same age and position on control plants. The experiment was carried out in a protected environment and conducted in a randomized complete block design in a subdivided plot scheme with four replicates. Re-translocation of B between neighboring leaves was observed when the plant was without K deficiency and with B deficiency. In this nutritional status, leaves next to fertilized leaf with B (F) showed higher B amount when compared to leaves of the same position of control plants. Evidence suggests that retranslocation of B over relatively short distances (between leaves) can be influenced by the nutritional status the cherry tomato plants.

A retranslocação de Boro (B) pode conferir maior tolerância à deficiência ou toxidez de B, resultando em plantas e frutos com melhor qualidade nutricional. A maioria das plantas não demonstra mobilidade floemática para o B, contudo, algumas plantas possuem mobilidade natural e outras a expressam sob condições de estresse, como o estresse nutricional. Nesse sentido, foi investigada a mobilidade floemática do B em plantas de tomate cereja com diferentes status nutricionais. As plantas foram cultivadas em solução nutritiva com doses adequada e insuficiente de Potássio (K) e B. Adicionalmente, as plantas receberam, de forma localizada, fertilização foliar com B em uma folha madura (F). Os teores e os conteúdos de B nas folhas vizinhas a F foram comparados com folhas de mesma idade e posição de plantas controle. O experimento foi realizado em ambiente protegido e conduzido no delineamento de blocos casualizados em esquema de parcelas subdivididas com quatro repetições. Evidenciou-se retranslocação de B entre folhas vizinhas quando a planta estava sem deficiência de K e com deficiência de B. Neste status nutricional, as folhas vizinhas à folha aplicada (F) apresentaram maiores teores e conteúdos de B quando comparadas às folhas de mesma posição das plantas controle. As evidências sugerem que a retranslocação de B em distâncias relativamente curtas (entre folhas) pode ser influenciada pelo status nutricional de plantas de tomate cereja.

Potassium , Boron , Lycopersicon esculentum , Phloem
Biosci. j. (Online) ; 36(3): 799-809, 01-05-2020. tab, graf
Article in English | LILACS | ID: biblio-1146970


The effects of intense cropping and potassium fertilization on potassium (K) dynamics and non-exchangeable K release from three lowland soils of Paraná State, Brazil, were investigated in this study. Samples of three lowland soils were fertilized or not with K and subjected to six successive croppings (soybeans, pearl millet, wheat, common beans, soybeans, and maize). The crops were grown in 8-L pots for 45 days, and at the end of the sixth cropping, the soil from each pot was sampled to the determination of soil K pools. The lowland soils differ in the ability to K supply to the plants in the short to medium term due to the wide range of origin material and the concentration of K in solution, exchangeable K, non-exchangeable K, and structural K. When the soils were not fertilized with K, the successive cropping resulted in continuous depletion process of non-exchangeable and exchangeable K; however, this depletion was less pronounced in soils with a higher potential buffer capacity of K. Non-exchangeable and exchangeable K concentrations were increased with the addition of K fertilizer, indicating the occurrence of K fixation in soil. The non-exchangeable K contribution to K nutrition of plants ranged from 44 to 69% in the treatments without the addition of K fertilizer, reporting the importance of non-exchangeable K pools in the supply of this nutrient to plants in agricultural production systems.

Os efeitos dos cultivos sucessivos e da adubação potássica na dinâmica de potássio (K) do solo e na mobilização do K não-trocável para às plantas em três solos de varzea do Estado do Paraná, Brasil, foram investigados neste estudo. Amostras dos três solos de várzea foram submetidas à adição ou não de fertilizante potássico e a seis cultivos sucessivos de plantas (soja, milheto, trigo, feijão, soja e milho). As culturas foram cultivadas em vasos de 8-L por 45 dias e, ao final do sexto cultivo, foram coletadas amostras de solos para a deteminação das diferentes formas de K do solo. Os solos de vázea diferenciaram-se na capacidade de suprir K às plantas a curto e médio prazo, devido à ampla variação do material de origem e dos teores de K na solução, K trocável, K não-trocável e K estrutural. Quando os solos não foram adubados com K, o cultivo sucessivo de plantas resultou em um processo contínuo de esgotamento das formas de K não-trocável e K trocável, sendo menos acentuada nos solos com maior poder tampão de potássio. Os teores de K não-trocável e K trocável aumentaram com a adição de fertilizantes potássicos, indicando a ocorrência de fixação de K pelo solo. A contribuição do K não-trocável para a nutrição das plantas durante os seis cultivos variou de 44 a 69% no tratamento sem adição de fertilizante potássico. Estes resultados reportam a importância das formas de K não-trocável para o suprimento deste nutriente às plantas nos sistemas de produção agrícolas.

Potassium , Soil , Agricultural Cultivation
Biosci. j. (Online) ; 36(3): 810-826, 01-05-2020. tab, graf
Article in English | LILACS | ID: biblio-1146972


Soil liming is a common practice in agriculture. It aims to reduce soil acidity and to supply calcium and magnesium. Lime, however, is not easily soluble in the soil, and its reaction products are often concentrated in the application zone, which is mainly the topsoil layer. In order to increase the concentration of nutrients in deeper layers, agricultural gypsum­a byproduct of phosphoric acid production process, rich in calcium and sulfur­is used. In this context, the objective of this study was to evaluate the chemical attributes of the oxysoil and the corn ́s yield to the application of gypsum associated with potassium (K) rates. The study was developed in Uberaba city, Minas Gerais state, Brazil. The factorial scheme was used 5x5, with five rates of K (0, 100, 180, 240, 360 kg ha-1 K2O) and five gypsum rates (0, 500, 1000, 2000, 4000 kg ha-1) in a randomized complete block design with four replications. The soil chemical attributes were evaluated at 0.0-0.20 m and 0.20-0.40 m depth and the biometric and productive attributes of corn. The application of gypsum resulted in the increase of calcium (Ca) and sulfur (S) contents in all depths; reduced the levels of pH, manganese, potential acidity (H + Al) in the 0.0-0.20 m depth, and increase the levels of base of saturation and sum of bases on the 0.20-0.40 m depth. Corn yield and biometric attributes no were influenced by the factors evaluated.

A calagem é uma prática comum na agricultura. Esta prática visa reduzir a acidez do solo, além de fornecer cálcio e magnésio. Contudo, devido ao fato de o calcário apresentar baixa solubilidade no solo, os produtos de sua reação ficam retidos na camada onde o produto foi aplicado, a qual geralmente é na camada superficial do solo. Para se aumentar a concentração de nutrientes em camadas mais profundas, o gesso agrícola - um subproduto da produção de ácido fosfórico, rico em cálcio e enxofre tem sido usado. Neste contexto, o objetivo deste trabalho foi avaliar a influência da aplicação de diferentes doses de gesso em associação a doses de potássio, nos atributos químicos do solo e na produtividade de grãos de milho. O estudo foi conduzido no Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro (IFTM), Campus Uberaba, localizado no município de Uberaba-MG, Brasil. O experimento foi instalado em esquema fatorial 5x5, sendo cinco doses de gesso (0, 500, 1000, 2000 e 4000 kg ha-1) e cinco doses de K2O (0, 100, 180, 240 e 360 kg ha-1) no delineamento em blocos completos casualizados, com quatro repetições. Os atributos químicos do solo foram avaliados nas camadas de 0,0 a 0,20 m e de 0,20 a 0,40 m, além das características biométricas e produtivas da cultura do milho. A aplicação de gesso resultou no aumento de cálcio e enxofre em ambas as profundidades; reduziu os níveis de pH, manganês, acidez potencial (H + Al) na camada de 0,0-0,20m; e, aumentou os níveis de saturação por bases e soma de bases na camada de 0,20-0,40 m. A produção de milho não foi influenciada pelos fatores avaliados.

Potassium , Soil , Calcium Sulfate , Zea mays
J. coloproctol. (Rio J., Impr.) ; 40(2): 143-148, Apr.-Jun. 2020. tab
Article in English | LILACS | ID: biblio-1134967


ABSTRACT Background Post-operative pain is the major consequence of Ksarasutra, Seton technique employed in Ayurvedic management of Low anal fistula. Surgeons are forced to prescribe Opioids and NSAIDs with pronounced untoward effects. Non pharmacological measures like Balneotherapy are used to improve circulation and relieve spasm in contemporary sciences. Aim To compare the efficacy of Khadira (Acacia catechu) and Sphatika (Potash alum) hot sitzbath with plain hot sitzbath in patients of low anal fistula treated with Ksarasutra. Method The study was single blind, double armed; prospective, randomized control clinical trial in which 30 patients were randomly allocated into two groups of 15 each on the basis of inclusion and exclusion criteria. Group A received hot sitzbath using Acacia catechu and alum infusion twice daily for 21 days. Group B received hot sitzbath using warm water for 21 days. The assessments were made on pain, post-surgical satisfaction burning sensation, tenderness, discharge, constipation, itching and incontinence. Result The disease was prevalent in the 4th decade of life, more in males (86.67%) involved in sedentary work (53.33%) residing in urban domicile, consuming mixed diet (100%). Both groups showed statistically significant improvement in outcome measures like pain, burning sensation, tenderness, discharge, constipation and itching. Conclusion On comparative analysis Acacia and Alum hot sitzbath was more effective in outcomes like pain, surgical satisfaction, burning sensation and discharge. There was no difference in the effect of both interventions with respect to outcome measures like constipation, itching and incontinence.

RESUMO Justificativa A dor pós-operatória é a principal consequência da técnica que utiliza seton de Ksarasutra no tratamento ayurvédico de fístula anal baixa. Os cirurgiões são impelidos a prescrever opiáceos e AINEs que possuem efeitos indesejáveis pronunciados. Medidas não farmacológicas como a balneoterapia são usadas nas ciências contemporâneas para melhorar a circulação e aliviar o espasmo. Objetivo Comparar a eficácia do banho quente de assento com Khadira (Acacia catechu) e Sphatika (Potash alum) com apenas banho de assento em pacientes com fístula anal baixa tratados com Ksarasutra. Método Estudo clínico prospectivo, cego e controlado de dois braços randomizados, no qual 30 pacientes foram alocados aleatoriamente em dois grupos de 15 pacientes cada com base nos critérios de inclusão e exclusão. O Grupo A recebeu banho de assento com Acacia catechu e infusão de alume duas vezes ao dia por 21 dias. O Grupo B recebeu banho de assento com água morna por 21 dias. Os desfechos avaliados foram dor, satisfação pós-cirúrgica, sensação de queimação, sensibilidade, corrimento, constipação, prurido e incontinência. Resultado A doença foi prevalente na 4ª década de vida, mais frequente no sexo masculino (86,67%), nos envolvidos em trabalho sedentário (53,33%), nos residentes em domicílios urbanos e nos que consumiam dieta mista (100%). Ambos os grupos apresentaram melhora estatisticamente significativa na avaliação dos resultados, tais como dor, sensação de queimação, sensibilidade, corrimento, constipação e prurido. Conclusão Na análise comparativa, o banho quente de assento com acácia e alume foi mais eficaz nos desfechos de dor, satisfação cirúrgica, sensação de queimação e corrimento. Não houve diferença em relação ao efeito de ambas as intervenções sobre os desfechos de constipação, prurido e incontinência.

Humans , Male , Female , Pain, Postoperative , Baths , Rectal Fistula/surgery , Areca , Potassium , Aluminum Sulfate , Acacia
Acta bioquím. clín. latinoam ; 54(1): 13-18, mar. 2020. graf, tab
Article in Spanish | LILACS | ID: biblio-1130574


La deteccion de trastornos metabolicos minerales puede explicar diversas anomalias fisiologicas que exigen para su interpretacion la comparacion con valores de referencia validados. El objetivo de este trabajo fue la determinacion de valores de referencia en la poblacion infantil uruguaya, de los analitos sodio, potasio, calcio, magnesio, fosforo y urato relacionados con la creatinina en muestras de la segunda miccion de la manana en 470 escolares (240 ninas y 230 ninos) con edades comprendidas entre 7 y 12 anos. Las medianas obtenidas fueron: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. A excepcion de los cocientes Na/Crea y K/Crea se encontro una disminucion de la excrecion de estos analitos con la edad, independientemente del sexo. Los valores obtenidos resultaron ser analogos a los de otras poblaciones con tipo de alimentacion similar.

The detection of mineral metabolic disorders can explain several pathologies which require the comparison with reference values for their interpretation. The aim of this study was to determine the reference values of 470 Uruguayan school children with ages between 7 and 12 for sodium, potassium, calcium, magnesium, phosporous and urate and their relationship with creatinine in urine samples of the second urination of the morning. The median obtained were: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. A diminishment of excretion with the age was found, regardless the sex, except for Na/Crea and K/Crea. The values obtained were similar to those of others populations with a similar diet.

A detecção de distúrbios metabólicos minerais pode explicar várias anomalias fisiológicas, que exigem a comparação com valores de referência validados para serem interpretados. O objetivo deste estudo foi determinar valores de referência na população infantil uruguaia, dos analitos sódio, potássio, cálcio, magnésio, fósforo e urato relacionados com a creatinina em amostras da segunda micção da manhã em 470 alunos (240 meninas e 230 meninos) com idades entre 7 e 12 anos. As medianas obtidas foram: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. Com exceção dos quocientes Na/Crea e K/Crea, foi encontrada uma diminuição na excreção destes analitos com a idade independentemente do sexo. Os valores obtidos foram análogos aos de outras populações com um tipo similar de dieta.

Humans , Male , Female , Child , Reference Values , Urine/chemistry , Phosphorus , Potassium , Sodium , Students , Uric Acid , Calcium , Determination , Creatinine , Diet , Magnesium , Minerals
Rev. Inst. Adolfo Lutz ; 79: 1-4, 31 mar. 2020. ilus
Article in Portuguese | ColecionaSUS, LILACS, ColecionaSUS, SES-SP, CONASS, SESSP-ACVSES, SESSP-IALPROD, SES-SP, SESSP-IALACERVO | ID: biblio-1342958


Foi realizada reavaliação sobre o estado de preservação de ovos de helmintos e cistos de protozoários mantidos por cerca de 40 anos em solução de iodo­mercurato de potássio a 0,2%. Foi observado que ovos de Schistosoma mansoni, Ancylostomidae e Trichuris trichiura e oocistos de Isospora belli mantiveram­se em condições adequadas para a sua identificação ao microscópio ótico comum. No material examinado, foi possível verificar a presença de miracídio em ovo de Schistosoma mansoni, forma larvada em ovo de T. trichiura e esporozoitos em oocistos de I. belli. (AU)

A reassessment was carried out on the preservation status of helminth eggs and protozoan cysts maintained for about 40 years in 0.2% potassium iodine­mercurate solution. It was observed that Schistosoma mansoni, Ancylostomidae and Trichiuris trichiura eggs and Isospora belli oocysts were kept in conditions suitable for their identification under a common light microscope. In the examined material, it was possible to verify the presence of miracidium in S. mansoni egg, larvae in T. trichiuraegg and sporozoites in I. belli oocysts. (AU)

Mercury Compounds , Storage of Substances, Products and Materials , Oocysts , Helminths , Iodine , Potassium
Medicina (B.Aires) ; 80(1): 87-90, feb. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1125042


El síndrome de Gitelman forma parte de las denominadas tubulopatías perdedoras de sal. El bloqueo parcial de la reabsorción de sodio en el túbulo contorneado distal determina la aparición de hipokalemia e hipomagnesemia. Se realizó un estudio descriptivo de una serie de cinco casos de síndrome de Gitelman (4 mujeres, de 28 a 85 años de edad) atendidos en nuestra institución entre los años 2004 y 2015. La forma de diagnóstico más frecuente en nuestra serie fue por hallazgo de laboratorio. El único síntoma clínico manifestado en forma espontánea fue astenia. En cuanto a los valores de laboratorio, la potasemia fue 2.5 ± 0.5 mmol/l, con un valor mínimo de 2.1. Adicionalmente, el valor de magnesio en sangre fue 1.3 ± 0.3 mg/dl. Como conclusión, observamos que las formas de presentación consisten en alteraciones bioquímicas con o sin manifestaciones inespecíficas, lo que representa actualmente la mayor dificultad diagnóstica y refuerza la importancia de lograr un diagnóstico oportuno, en especial en pacientes jóvenes y con valores críticos de potasio sérico.

Gitelman syndrome is one of the salt losing tubulopathies. Hypokalemia and hypomagnesemia appear in the setting of the partial blockade of salt absorption in the distal tubule. We conducted a descriptive study of a case series of five patients with Gitelman syndrome (4 women, from 28 to 85 years) in our institution, between the years 2004 and 2015. The most frequent form of diagnosis in our series was by laboratory finding. The only acknowledged clinical symptom was malaise. Regarding laboratory findings, the mean potassemia was of 2.5 ± 0.5 mmol/l, with a minimum value of 2.1 mmol/l. Additionally, the serum magnesium value was of 1.3 ± 0.3 mg/dl. In conclusion, we observed that the forms of presentation consist of biochemical alterations with or without nonspecific manifestations, which currently represents the greatest diagnostic difficulty and reinforces the importance to achieve a timely diagnosis, especially in young patients with critical serum potassium values.

Humans , Male , Female , Adult , Middle Aged , Aged, 80 and over , Gitelman Syndrome/diagnosis , Gitelman Syndrome/therapy , Potassium/analysis , Asthenia/diagnosis , Calcium/analysis , Gitelman Syndrome/metabolism , Magnesium/analysis