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1.
Article in English | LILACS, BBO | ID: biblio-1346679

ABSTRACT

ABSTRACT Objective: To evaluate the effectiveness of oil pulling in the management of oral submucous fibrosis (OSMF). Material and Methods: A total of 62 patients clinically and histopathologically diagnosed as OSMF were incorporated in the present study. The subjects are randomly divided equally into two groups, Group A (oil pulling group) and Group B (placebo group). Subjects in Group A were asked to perform OP with sesame oil on an empty stomach in the morning for 3 months and Group B was given placebo capsules for 3 months. Assessment of various clinical parameters was done regularly, and data were analyzed using the Chi-square test. Results: Eighty-two percent had a habit of betel nut chewing, while 18% of the patients had tobacco chewing habits, which were among the main causative factors for OSMF. Clinical improvements in mouth opening, tongue protrusion, difficulty in speech and deglutition, and burning sensation were significant in the Group A. None of the patients reported any discomfort or side effects. The symptoms were not severe in nature and resolved in few days without stopping the therapy. Conclusion: Oil pulling can bring about significant clinical improvements in the symptoms like a mouth opening and tongue protrusion.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Oral Submucous Fibrosis/pathology , Precancerous Conditions/pathology , Therapeutics , Effectiveness , Sesame Oil , Chi-Square Distribution , Visual Analog Scale , India/epidemiology
2.
J. oral res. (Impresa) ; 9(2): 111-115, abr. 30, 2020. tab
Article in English | LILACS | ID: biblio-1151906

ABSTRACT

Objetive: To characterize patients diagnosed with oral epithelial dysplasia and carcinoma in situ, according to their severity, location, age, sex and smoking habits. Materials and Methods: A descriptive study, based on 126 histopathological reports of biopsies diagnosed with mild, moderate, severe epithelial dysplasia and carcinoma in situ, with information regarding anatomical location, age and gender of the patient, recorded in the biopsy reports of the histopathology services of the Faculty of Dentistry of Andrés Bello University and Major University, between the years 2000 and 2014. The dichotomous qualitative variables were described based on percentage and age using the Shapiro-Wilk test, presenting as average and standard deviation, in the STATA 12® program (StataCorpLP, Texas, USA). Result: A similar frequency was found for men and women diagnosed with OED, 53.17% and 46.83% respectively. A mild degree of OED was the most diagnosed in both sexes. The group most affected by OED was between 50 and 69 years old (57.94%) and the most frequent anatomic location was the lateral border of the tongue (34.13%). Conclusion: Most of the analyzed cases corresponded to mild degrees of dysplasia; however, it is important to always carry out a histopathological diagnosis of the lesion, patient follow-up and education regarding risk habits.


Objetivo: Caracterizar a pacientes con diagnóstico de displasia epitelial oral (DEO) y carcinoma in situ (CIS) según su severidad, localización, edad, género y hábito tabáquico. Materiales and Métodos: Se realizó un estudio descriptivo, en base a 126 informes histopatológicos de biopsias diagnosticadas con displasia epitelial leve, moderada, severa y carcinoma in situ, que contaban con información relativa a localización del diagnóstico, edad y género del paciente, registrados en los informes de biopsias de los servicios de histopatología de la Facultad de Odontología de la Universidad Andrés Bello y Universidad Mayor, entre los años 2000 y 2014. Las variables cualitativas dicotómicas se describieron en base a porcentaje y la edad mediante el test de Shapiro-Wilk, presentándose como media y desviación estándar, en el programa STATA 12 ® (StataCorpLP, Texas, USA). Resultados: Se encontró una frecuencia levemente aumentada de mujeres y hombres con diagnóstico de DEO, 67 (53,17%) y 59 (46,83%), respectivamente. El grado leve de DEO fue el más diagnosticado en ambos sexos. El grupo más afectado por DEO fue entre los 50 a 69 años (57,94%) y la localización anatómica más frecuente fue el borde lateral de la lengua (34,13%). Conclusión: La mayoría de los casos analizados correspondieron a grados leve de displasia; no obstante, es importante realizar siempre un diagnóstico histopatológico de la lesión, seguimiento al paciente y educación en cuanto a hábitos de riesgo.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Precancerous Conditions/pathology , Tobacco Use Disorder , Mouth Neoplasms/pathology , Carcinoma in Situ , Smoking , Epidemiology, Descriptive
3.
Braz. oral res. (Online) ; 34: e002, 2020. tab, graf
Article in English | LILACS | ID: biblio-1055528

ABSTRACT

Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF)궱, oral lichen planus, and (OSMF)궱 with leucoplakia. The samples were also classified as non-dysplastic, or with mild, moderate, and severe dysplasia according to their histopathological reports. The salivary miRNA-21 and 31 expressions were studied using real-time PCR. The statistical analysis was carried out using SPSS version 22. Salivary miRNA-21 (p-value = 0.02) and 31 (p-value = 0.01) were significantly upregulated in severe dysplasia compared with control. Among the different lesions, leucoplakia had significant upregulation of miRNA-21 and 31. miRNA-21 can be used as a diagnostic marker with specificity of 66% and sensitivity of 69%. The area under the ROC curve was 0.820 for miRNA-21 and 0.5 for miRNA-31, which proved that miRNA-21 is a better diagnostic marker than miRNA-31 for OPMD.


Subject(s)
Humans , Precancerous Conditions/pathology , Saliva/chemistry , Mouth Neoplasms/pathology , MicroRNAs/analysis , Oral Submucous Fibrosis/pathology , Reference Values , Severity of Illness Index , Leukoplakia, Oral/pathology , Mouth Neoplasms/chemistry , Biomarkers, Tumor/analysis , Case-Control Studies , Linear Models , ROC Curve , Analysis of Variance , Lichen Planus, Oral/pathology , Real-Time Polymerase Chain Reaction
4.
Int. j. morphol ; 37(3): 917-927, Sept. 2019. graf
Article in Spanish | LILACS | ID: biblio-1012376

ABSTRACT

El carcinoma gástrico (CG) de tipo intestinal se origina en un epitelio displásico, que a su vez se desarrolla en medio de una atrofia gástrica (AG) y metaplasia intestinal (MI). La infección por Helicobacter pylori (HP) es la causa más frecuente de AG, causando una pangastritis atrófica multifocal. Entre otras condiciones que producen inflamación crónica de la mucosa gástrica se encuentran también la gastritis autoinmune y la anemia perniciosa. El marco conceptual sobre el cual descansa gran parte de la investigación actual y nuestra comprensión de los cambios que ocurren en la mucosa gástrica se debe a la denominada "cascada de Correa"; quien planteó que la mucosa gástrica crónicamente inflamada, da paso a la AG, que va adquiriendo focos de MI y en dicho epitelio se desarrollará finalmente una displasia (DIS). Se ha acuñado el término lesiones preneoplásicas gástricas (LPG), para referirse a: AG, MI y DIS.Después de la erradicación de HP, se ha demostrado una reducción general de la incidencia de CG; efecto que no es tan claro, cuando la pangastritis por HP ha evolucionado a AG extensa. De tal modo que el efecto de la erradicación de HP medido a través de EC, ha sido poco consistente. La AG grave diagnosticada por histología representa la condición de mayor riesgo. Por otra parte, la MI puede ser de tipo intestinal (delgado-entérica ó incompleta) y la colónica (colónica ó completa) considerándose a esta última, como la variedad de peor pronóstico. El diagnóstico histológico de este tipo de lesiones determina que quien las padece, debe someterse a vigilancia endoscópica. El objetivo de este manuscrito fue resumir la evidencia existente respecto de las LPG, en términos de su caracterización morfológica y sus repercusiones diagnóstico-terapéuticas (significado patológico, graduación del riesgo, vigilancia recomendada; y factores de riesgo).


Gastric carcinoma (GC) of intestinal type, originates from a dysplastic epithelium, which in turn develops in the midst of gastric atrophy (GA) and intestinal metaplasia (IM). Helicobacter pylori (HP) infection is the most frequent cause of GA, causing a multifocal atrophic pangastritis. Among other conditions that produce chronic inflammation of gastric mucosa are also autoimmune gastritis and pernicious anemia. The conceptual framework on which much of current research rests and our understanding of the changes that occur in the gastric mucosa is due to the so-called "Correa waterfall"; who stated that gastric mucosa chronically inflamed, gives way to the GA, which is acquiring foci of IM and in said epithelium a dysplasia (DIS) will eventually develop. The term precancerous conditions (PCC) of the gastric mucosa have been coined to refer to: GA, IM and DIS. After HP eradication, a general reduction in the incidence of GC has been demonstrated; effect that is not so clear, when pangastritis by HP has evolved to extensive GA. Thus, the effect of HP eradication measured through clinical trials has been inconsistent. Severe GA diagnosed represents the highest risk condition. On the other hand, IM can be enteric (grade I), enterocolic (grade II) or colonic (grade III); considering IM III as the variety with the worst prognosis. Histological diagnosis of gastric PCC, determines that the one who suffers them, must undergo endoscopic surveillance. The aim of this manuscript was to update morphological aspects and diagnostic-therapeutic scope of gastric PCC.


Subject(s)
Humans , Precancerous Conditions/pathology , Stomach Neoplasms/pathology , Precancerous Conditions/microbiology , Stomach Neoplasms/microbiology , Risk Factors , Helicobacter pylori , Helicobacter Infections/complications , Helicobacter Infections/pathology , Risk Assessment , Gastritis, Atrophic/microbiology , Gastritis, Atrophic/pathology , Intestines/microbiology , Intestines/pathology , Metaplasia/microbiology , Metaplasia/pathology
5.
Arq. gastroenterol ; 56(1): 41-44, Jan.-Mar. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001321

ABSTRACT

ABSTRACT BACKGROUND: Esophageal cancer is the eighth most common cancer. The prognosis is bleak in patients with advanced stages. Patients with early disease have a better prognosis than those with advanced stage. There are several techniques for the screening of premalignant and superficial lesions including chromoendoscopy. OBJECTIVE: This article aimed to determine the effectiveness of chromoendoscopy with toluidine blue combined with Lugol's solution for diagnosis of esophageal premalignant and superficial neoplastic lesions in high risk patients. METHODS: Routine white light upper endoscopy was performed. Toluidine blue was sprayed from the gastroesophageal junction to 20 cm of the dental arch. Then the uptake dye areas were characterized. Later Lugol's solution was sprayed. Areas with less-intense staining were characterized. Biopsy of the toluidine blue capturing areas and areas with less-intense staining of Lugol's solution were taken. In the cases where lesions were not evidenced after application of dyes, biopsies four quadrants of the esophageal mucosa were taken. The samples were evaluated by a digestive pathologist. RESULTS: Barrett's esophagus was the most common premalignant lesion and the early neoplastic lesion was adenocarcinoma with a sensitivity of 100%, specificity 85.7%, positive predictive value 30%, negative predictive value 100%, positive likelihood ratio 7 negative likelihood ratio 0. CONCLUSION: Chromoendoscopy with toluidine blue combined with Lugol's solution is a useful tool in the screening of esophageal premalignant lesions and superficial neoplasms.


RESUMO CONTEXTO: O câncer de esôfago é o oitavo câncer mais comum. O prognóstico é sombrio em pacientes com estágios avançados. Pacientes com doença precoce têm um melhor prognóstico do que aqueles com estágio avançado. Existem várias técnicas para a triagem de lesões pré-malignas e superficiais, incluindo cromoendoscopia. OBJETIVO: Este artigo objetivou determinar a efetividade da cromoendoscopia com azul de toluidina combinada com a solução de Lugol para o diagnóstico de lesões neoplásicas pré-malignas e superficiais esofágicas em pacientes de alto risco. MÉTODOS - A endoscopia de luz branca de rotina foi realizada de forma rotineira. O azul do toluidina foi pulverizado desde a junção gastroesofágica até 20 cm da arcada dentária. As áreas impregnadas pela tintura da tomada foram então caracterizadas. Mais adiante a solução de Lugol foi pulverizada. Áreas com coloração menos intensa foram caracterizadas. Foram realizadas biópsias das áreas de captura de azul de toluidina e áreas com coloração menos intensa da solução de Lugol. Nos casos onde as lesões não foram evidenciadas após a aplicação das tinturas, foram feitas biópsias em quatro quadrantes da mucosa esofágica. As amostras foram avaliadas por um patologista especializado. RESULTADOS: O esôfago de Barrett foi a lesão pré-maligna mais frequente e a lesão neoplásica precoce foi adenocarcinoma com sensibilidade de 100%, especificidade de 85,7%, valor preditivo positivo de 30%, valor preditivo negativo 100%, razão de verossimilhança positiva 7 e razão de verossimilhança negativa 0. CONCLUSÃO: A cromoendoscopia com azul de toluidina combinada com a solução de Lugol é uma ferramenta útil na triagem de lesões pré-malignas esofágicas e neoplasias superficiais.


Subject(s)
Humans , Male , Female , Adult , Precancerous Conditions/diagnostic imaging , Esophageal Neoplasms/diagnostic imaging , Esophagoscopy/methods , Early Detection of Cancer/methods , Precancerous Conditions/pathology , Tolonium Chloride/administration & dosage , Barrett Esophagus/pathology , Barrett Esophagus/diagnostic imaging , Esophagitis, Peptic/diagnostic imaging , Cross-Sectional Studies , Predictive Value of Tests , Prospective Studies , Sensitivity and Specificity , Coloring Agents/administration & dosage , Esophageal Mucosa/pathology , Esophageal Mucosa/diagnostic imaging , Iodides/administration & dosage , Middle Aged
6.
Rev. bras. ginecol. obstet ; 41(3): 176-182, Mar. 2019. tab
Article in English | LILACS | ID: biblio-1003547

ABSTRACT

Abstract Objective The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym). Methods The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018. Results A total of 57 women were included, with a mean age of 48.42 years old (15.43- 80.77), of which 30 (52.63%) were postmenopausal, and 18 (31.58%) were < 40 years old. All of the women underwent surgery. A total of 37 women (64.91%) were submitted to complete surgical staging for BOT, and none (0/57) were submitted to pelvic or paraortic lymphadenectomy. Chemotherapy was administered for two patients who recurred. The final histological diagnoses were: serous in 20 (35.09%) cases, mucinous in 26 (45.61%), seromucinous in 10 (17.54%), and endometrioid in 1 (1.75%) case. Intraoperative analyses of frozen sections were obtained in 42 (73.68%) women, of which 28 (66.67%) matched with the final diagnosis. The mean follow-up was of 42.79 months (range: 2.03-104.87 months). Regard ingthe current status of the women, 45(78.95%) are alive without disease, 2(3.51%) arealive with disease, 9 (15.79%) had their last follow-up visit > 1 year beforethe performanceof the present study but arealive, and 1 patient(1.75%) died of another cause. Conclusion Women in the present study were treated according to the current guidelines and only two patients recurred.


Resumo Objetivo O objetivo do presente estudo foi descrever uma série de 57 mulheres com tumores borderline de ovário (TBO) em relação às características histológicas, clínicas, e ao manejo do tratamento realizado no Departamento de Obstetrícia e Ginecologia da Universidade Estadual de Campinas (Unicamp). Métodos O presente estudo retrospectivo analisou dados obtidos dos registros clínicos e histopatológicos de mulheres com TBO tratadas em um único centro oncológico de 2010 a 2018. Resultados Um total de 57 mulheres foram incluídas, com uma média de idade de 48,42 anos (15,43-80,77), das quais 30 (52,63%) eram menopausadas, e 18 (31,58%) tinham < 40 anos. Todas as mulheres foram operadas. Um total de 37 mulheres (64,91%) foram submetidas a cirurgia de estadiamento completo para TBO, e nenhuma foi submetida a linfadenectomia pélvica ou paraórtica. O tratamento com quimioterapia foi administrado em duas pacientes que recidivaram. Os diagnósticos histológicos finais foram: seroso em 20 mulheres (35,09%), mucinoso em 26 (45,61%), seromucinoso em 10 (17,54%) e endometrióide em 1 (1,75%). A avaliação histológica intraoperatória foi realizada em 42 (73,68%) das mulheres, das quais 28 (66,67%) foram compatíveis com os diagnósticos finais. O tempo médio de seguimento foi de 42,79 meses (variando de 2,03 a 104,87 meses). Em relação ao status atual das mulheres, 45 (78.95%) estão vivas sem doença, 2 (3,51%) estão vivas com doença, 9 (15.79%) tiveram a última consulta de seguimento há > 1 ano antes da realização do presente estudo, mas estão vivas, e 1 paciente faleceu por outra causa. Conclusão As mulheres do presente estudo foram tratadas de acordo com as recomendações atuais e apenas duas mulheres apresentaram recorrência.


Subject(s)
Humans , Female , Adolescent , Adult , Aged , Aged, 80 and over , Young Adult , Ovarian Neoplasms/pathology , Precancerous Conditions/pathology , Ovarian Neoplasms/surgery , Ovarian Neoplasms/drug therapy , Precancerous Conditions/surgery , Precancerous Conditions/drug therapy , Brazil , Cancer Care Facilities/statistics & numerical data , Menopause/physiology , Retrospective Studies , Treatment Outcome , Age Distribution , Organ Sparing Treatments/statistics & numerical data , Salpingo-oophorectomy/statistics & numerical data , Hysterectomy/statistics & numerical data , Middle Aged , Neoplasm Recurrence, Local/etiology , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/drug therapy , Antineoplastic Agents/therapeutic use
7.
Braz. j. med. biol. res ; 52(1): e7517, 2019. tab
Article in English | LILACS | ID: biblio-974267

ABSTRACT

The aim of this study was to explore the value of different combination schemes of liquid-based cytology (LBC) and high-risk human papilloma virus (HPV) test in the screening of high-grade (≥CIN 2) cervical lesions. From 5727 women who had undergone examinations with LBC and high-risk HPV test, 1884 patients with positive results of either or both LBC and HPV test were included in this study and underwent cervical biopsy. Based on the pathological examination results, comparisons of the assessment indicators of all diagnostic tests were made, and the application values of LBC and high-risk HPV test and different combination schemes of the two in the screening of high-grade (≥CIN II) cervical lesions were estimated. Compared with the single test method, the sensitivity and negative predictive value of the combination scheme of LBC+HPV (with one positive result) were increased significantly (98.7% and 99.7%), but the specificity (60.8%) and accuracy rate (65.4%) dropped significantly (P<0.05). The sensitivity of LBC+HPV (with two positive results) was the lowest (80.7%), but the specificity and accuracy rate were the highest (83.5% and 83.1%, P<0.05). Z test showed that differences in the screening efficiency of four schemes were not statistically significant (P>0.05). Both LBC and HPV test were effective methods in the screening of high-grade cervical lesions; combination of the two tests did not improve the screening efficiency, but the scheme of LBC+HPV (with two positive results) significantly increased the sensitivity and negative predictive value, which was of better cost-benefit value.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Precancerous Conditions/pathology , Cervical Intraepithelial Neoplasia/pathology , Papillomavirus Infections/pathology , Liquid Biopsy/methods , Predictive Value of Tests , Sensitivity and Specificity , Papillomavirus Infections/complications , Diagnostic Screening Programs
8.
Biol. Res ; 52: 30, 2019. tab, graf
Article in English | LILACS | ID: biblio-1011432

ABSTRACT

BACKGROUND: Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenvironment and gene mutation in C57BL/6 mice. METHODS: Immune and bacterial prostatitis mouse models were created through abdominal subcutaneous injection of rat prostate extract protein immunization (EAP group) or transurethral instillation of uropathogenic E. coli 1677 (E. coli group). Prostate histology, serum cytokine level, and genome-wide exome (GWE) sequences were examined 1, 3, and 6 months after immunization or injection. RESULT: In the EAP and E. coli groups, immune cell infiltrations were observed in the first and last months of the entire experiment. After 3 months, obvious proliferative inflammatory atrophy (PIA) and prostatic intraepithelial neoplasia (PIN) were observed accompanied with fibrosis hyperplasia in stroma. The decrease in basal cells (Cytokeratin (CK) 5+/p63+) and the accumulation of luminal epithelial cells (CK8+) in the PIA or PIN area indicated that the basal cells were damaged or transformed into different luminal cells. Hic1, Zfp148, and Mfge8 gene mutations were detected in chronic prostatitis somatic cells. CONCLUSION: Chronic prostatitis induced by prostate extract protein immunization or E. coli infection caused a reactive prostatic inflammation microenvironment and resulted in tissue damage, aberrant atrophy, hyperplasia, and somatic genome mutation.


Subject(s)
Animals , Male , Mice , Precancerous Conditions/genetics , Prostatitis/genetics , Escherichia coli Infections/pathology , Mutation/genetics , Precancerous Conditions/microbiology , Precancerous Conditions/pathology , Prostatitis/microbiology , Prostatitis/pathology , Immunohistochemistry , Chronic Disease , Disease Models, Animal , Mice, Inbred C57BL
9.
Rev. odontol. UNESP (Online) ; 48: e20190005, 2019. tab
Article in English | LILACS, BBO | ID: biblio-1043177

ABSTRACT

Abstract Introduction Actinic cheilitis is a inflammatory condition affecting mainly the lower lip and it is caused by chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. Objective Identifying clinical and histopathologic characteristics in 40 cases histopathologically diagnosed as actinic cheilitis. In addition, to investigate possible associations between these aspects. Method Defined as an observational, transversal, retrospective and descriptive study, it registered data regarding age, gender, occupation, symptomatology, records of sun exposure, frequency of sunblock use, tabagism, skin color, clinical aspect and histopathological classification. The data was submitted to the chi square test of Pearson (p<0.05). Result There was a predominance of male gender, leucodermia, and ages ranging between 50 and 60 years. The most common occupation was farming. From our sample, 85% had history of chronic sun exposure, in which 50% reported the use of some type of sunblock and only 25% were smokers. The main clinical condition was non-ulcerated leukoplakia and in the histopathological study, the hyperkeratosis were more common. A correlation between the degree of tissue alteration verified in the histopathological diagnosis and the studied clinical variables was not established (p=0.112). Conclusion The clinical aspect of the wound can conceal tissue alterations in different stages, emphasizing the importance of a premature diagnosis.


Resumo Introdução A queilite actínica e uma condição de natureza inflamatória que acomete o lábio inferior, e é causada pela exposição prolongada e crônica dos lábios à radiação ultravioleta proveniente dos raios solares. Objetivo Identificar as características clínicas e histopatológicas em uma série de 40 casos diagnosticados histopatologicamente como queilite actínica. Além disso, investigar possíveis associações entre estes aspectos. Método Caracterizado como um estudo observacional, transversal, retrospectivo e descritivo. Foram registrados dados a respeito da idade, gênero, ocupação, sintomatologia, histórico de exposição ao sol, uso de proteção solar, tabagismo, cor da pele, aspecto clínico e classificação histopatológica. Os dados foram submetidos ao teste de Qui-Quadrado de Pearson (p<0,05). Resultado Houve uma prevalência do gênero masculino, leucodermas, com faixa etária entre 50 e 60 anos e a ocupação mais presente foi a de agricultor. Da amostra, 85% apresentou histórico de exposição crônica ao sol, onde 50% relatou uso de algum tipo de proteção solar e apenas 25% era tabagista. A principal apresentação clínica foi leucoplasia não ulcerada, e no estudo histopatológico as hiperceratoses foram as mais presentes. Não foi possível correlacionar o grau de alteração tecidual verificada no diagnóstico histopatológico com as variáveis clínicas estudadas (p=0,112). Conclusão Não foi possível correlacionar o grau de alteração tecidual verificada no diagnóstico histopatológico com os aspectos clínicos observados. O aspecto clínico da lesão pode mascarar alterações teciduais em diversos estágios, o que enaltece a importância do diagnóstico precoce.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Precancerous Conditions/pathology , Cheilitis , Clinical Study , Pathology, Clinical , Clinical Diagnosis
11.
Gastroenterol. latinoam ; 29(1): 9-15, 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-1116687

ABSTRACT

Background: Atrophic gastritis (AG) and intestinal metaplasia (IM) are stages that appear in the process of gastric carcinogenesis. Their presence requires programmed endoscopic vigilance. Objectives: To determine the frequency of AG and IM in gastric biopsies (GB) taken according to Sydney Protocol and to correlate them with endoscopic findings. Methods: Retrospective descriptive analysis of 233 upper gastrointestinal endoscopies with GB per Sydney Protocol. OLGA (Operative Link for Gastritis Assessment) and OLGIM (Operative Link for Gastric Intestinal Metaplasia Assessment) scores were calculated based on the GB description. Endoscopic findings were analyzed for atypical findings and compared to the GB report. Statistic analysis for Kappa and ANOVA was performed via Stata 12. Results: Mean age of patients was 58 ± 12 years. 69% were women. The frequency of AG and IM was 44% and 33% in the antrum, 31% and 20% in the angular incisure and 14% and 9% in the body, respectively. AG and IM were more frequent in the antrum (p < 0.05). AG and IM were more severe in the angular incisure and body (p < 0.05). We were unable to calculate OLGA and OLGIM in 6% and 9% of cases, respectively, due to absence of severity description in GB. 53% were OLGA 0, 42% OLGA I-II and 5% OLGA III-IV. 70% were OLGIM 0, 25% OLGIM I-II and 5% OLGIM III-IV. Agreement between endoscopic and histological findings was best for IM in the antrum (75.5%, Kappa 0.4). Sensitivity and specificity of endoscopic findings were 39% and 70% for AG, and 30% and 85% for IM, respectively. Conclusion: AG and IM are frequent findings in our patients. Due to the low endoscopic sensitivity for AG and IM, we suggest a systematic GB sampling using Sydney Protocol in patients over 40 years old.


Introducción: La gastritis crónica atrófica (GCA) y la metaplasia intestinal (MI) son etapas en el proceso de carcinogénesis gástrica, su presencia requiere control endoscópico programado. Objetivos: Determinar la frecuencia de GCA y MI en biopsias gástricas (BG) por protocolo de Sydney y relacionarlas con el hallazgo endoscópico. Métodos: Estudio descriptivo mediante revisión de 233 endoscopias digestivas altas con BG por Protocolo Sydney. Se graduó puntaje OLGA (Operative Link for Gastritis Assessment) y OLGIM (Operative Link for Gastric Intestinal Metaplasia Assessment) según la descripción de la BG. Se definió el hallazgo endoscópico según su informe y se comparó con BG como patrón de referencia. Estadística: Stata 12 para Kappa y ANOVA. Resultados: Edad promedio 58 ± 12 años, 69% mujeres. La frecuencia de GCA y MI en antro fue de 44 y 33%, en ángulo 31 y 20% y en cuerpo 14 y 9%, respectivamente. Hubo mayor frecuencia de GCA y MI en antro (p < 0,05). La graduación de GCA y MI fue mayor en ángulo y cuerpo (p < 0,05). No se obtuvo OLGA en 6% y OLGIM en 9% por ausencia de graduación. La frecuencia de OLGA 0 fue de 53%, OLGA I-II 42%, OLGA III-IV 5%, OLGIM O 70%, OLGIM I-II 25% y OLGIM III-IV 5%. La mejor correlación se observó entre la MI antral endoscópica con la histológica (75,5%, Kappa 0,4). La sensibilidad y especificidad endoscópica fue de 39 y 70% para GCA y 30 y 85% para MI. Conclusión: GCA y MI son hallazgos frecuentes en nuestros pacientes. Por la baja sensibilidad endoscópica en la identificación de GCA y MI sugerimos la toma sistemática de BG por protocolo de Sydney en pacientes mayores de 40 años.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Precancerous Conditions/diagnosis , Precancerous Conditions/epidemiology , Gastritis, Atrophic/diagnosis , Gastritis, Atrophic/epidemiology , Metaplasia/diagnosis , Metaplasia/epidemiology , Precancerous Conditions/pathology , Biopsy/methods , Chile/epidemiology , Clinical Protocols , Mass Screening/methods , Epidemiology, Descriptive , Prevalence , Retrospective Studies , Analysis of Variance , Endoscopy, Gastrointestinal , Sensitivity and Specificity , Gastric Mucosa/pathology , Gastritis, Atrophic/pathology , Metaplasia/pathology
12.
Rev. cuba. obstet. ginecol ; 43(3): 4-14, jul.-set. 2017. ilus, tab
Article in Spanish | LILACS, CUMED | ID: biblio-901310

ABSTRACT

Introducción: el cáncer cervicouterino es una de las amenazas más graves para la vida de las mujeres. Actualmente en el mundo lo padecen más de un millón de ellas. En Ecuador, ocupa el segundo lugar en incidencia y causa 1,2 por ciento de muertes anuales en el país. Su detección oportuna es posible gracias a la citología cervicovaginal que contribuye eficazmente a detectar lesiones precancerosas y disminuir significativamente el carcinoma del cuello uterino. El estudio de la paciente se complementa con colposcopia y toma de biopsia para aumentar la certeza diagnóstica. En algunos casos, no se ha observado una buena correlación diagnóstica. Objetivo: determinar la relación citocolpohistológica en pacientes atendidas con Papanicolaou alterado en consulta de Patología del Tracto Genital Inferior. Métodos: se revisaron 82 historias clínicas de pacientes atendidas con Papanicolaou alterado en la consulta de Patología del Tracto Genital Inferior en el Hospital Básico Píllaro de Ecuador desde abril de 2015 hasta abril de 2016. Resultados: del total de pacientes, 32,9 por ciento tenían entre 30 y 39 años de edad; 90,2 por ciento iniciaron sus relaciones sexuales durante la adolescencia. De ellas, 89 por ciento tuvo entre una y cinco parejas sexuales; 59,7 por ciento tuvo entre uno y tres partos. Existió un 21,4 por ciento de correlación cito-colposcópica en el diagnóstico de las lesiones intraepiteliales de bajo grado. La relación colpo-histológica mostró un 87,5 por ciento de coincidencias en las lesiones intraepiteliales de bajo grado y en las lesiones intraepiteliales de alto grado un 71,4 por ciento. Conclusiones: el inicio precoz de la actividad sexual, las múltiples parejas sexuales y la multiparidad continúan resaltando en la aparición de las lesiones premalignas del cuello uterino(AU)


Introduction: Cervical cancer is one of the most serious threats to the lives of women. In the world today, more than a million of them suffer from it. In Ecuador, it ranks second in incidence and causes 1.2 percent of annual deaths in the country. Its timely detection is possible thanks to cervicovaginal cytology that contributes effectively to detecting precancerous lesions and significantly decreasing carcinoma of the cervix. The patient's study is complemented by colposcopy and biopsy to increase diagnostic certainty even when good diagnostic correlation has not been observed in some cases. Objective: Determine the cyto-colpo-histological relationship in patients treated due to altered Papanicolaou, in consultation of Pathology of the Lower Genital Tract in Píllaro Basic Hospital. Ecuador. Methods: In the present study, we reviewed 82 clinical records of patients treated with altered Papanicolaou in the Lower Genital Tract Pathology consultation at the Píllaro Basic Hospital, Ecuador from April 2015 to April 2016. Results: 32.9 percent of patients aged 30 to 39 years; 90.2 percent started sexual intercourse throughout adolescence. 89 percent had one to five sexual partners. 59.7 percent had one to three deliveries. There was 21.4 percent cyto-colposcopic correlation in the diagnosis of low-grade intraepithelial lesions (LSIL). The colpo-histological relationship showed 87.5 percent of coincidences in the LSIL and 71.4 percent. showed high-grade intraepithelial lesions (HSIL)(AU)


Subject(s)
Humans , Female , Adult , Uterine Cervical Neoplasms/prevention & control , Uterine Cervical Neoplasms/diagnostic imaging , Colposcopy/methods , Precancerous Conditions/pathology , Epidemiology, Descriptive , Retrospective Studies , Histocytological Preparation Techniques/methods , Ecuador , Papanicolaou Test/methods
13.
An. bras. dermatol ; 92(1): 107-109, Jan.-Feb. 2017. graf
Article in English | LILACS | ID: biblio-838021

ABSTRACT

Abstract: Nevus spilus is a melanocytic cutaneous lesion consisting of a light brown background macule with numerous superimposed darker maculopapular speckles. Melanoma arising from a nevus spilus is rare, with less than 40 cases reported to date. The absolute risk for malignant transformation is not well defined, lacking a standardized management approach. We report a new case of melanoma arising from nevus spilus, with the additional peculiarity of multifocality. We offer our recommendations for the management of the condition.


Subject(s)
Humans , Male , Aged, 80 and over , Skin Neoplasms/pathology , Melanoma/pathology , Neoplasms, Multiple Primary/pathology , Nevus, Pigmented/pathology , Precancerous Conditions/pathology , Melanocytes/pathology
14.
Einstein (Säo Paulo) ; 14(1): 35-40, Jan.-Mar. 2016. tab
Article in English | LILACS | ID: lil-778489

ABSTRACT

ABSTRACT Objective To determine the incidence of potentially malignant oral lesions, and evaluate and correlate their clinical and pathological aspects. Methods The sample consisted of cases clinically diagnosed as oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, and oral lichen planus treated at a diagnostic center, between May 2012 and July 2013. Statistical tests were conducted adopting a significance level of 5% (p≤0.05). Results Out of 340 patients, 106 (31.2%) had potentially malignant oral lesions; and 61 of these (17.9%) were submitted to biopsy. Actinic cheilitis was the most frequent lesion (37.5%) and the lower lip was the most affected site (49.6%). Among 106 patients in the sample, 48 (45.3%) reported nicotine consumption, 35 (33%) reported alcohol intake and 34 (32.1%) sun exposure while working. When clinical and histopathological diagnoses were compared, oral erythroplakia and atypical ulcer were the lesions that exhibited greater compatibility (100% each). Conclusion In most cases, clinical and histopathological diagnoses were compatible. An association between the occurrence of erythroplakia, leukoplakia and erythroleukoplakia with smoking was observed. Similarly, an association between actinic cheilitis and sun exposure was noted. Erythroleukoplakia presented the highest malignancy grade in this study. Finally, dental surgeons should draw special attention to diagnosis of potentially malignant oral lesions, choose the best management, and control the lesions to avoid their malignant transformation.


RESUMO Objetivo Verificar a incidência das lesões orais potencialmente malignas, e avaliar e correlacionar seus aspectos clínico-patológicos. Métodos A amostra foi composta pelos casos diagnosticados clinicamente como leucoplasia oral, eritroplasia oral, eritroleucoplasia, queilite actínica e líquen plano oral em um serviço de diagnóstico no período entre maio de 2012 e julho de 2013. Foram realizados testes estatísticos adotando-se nível de significância de 5% (p≤0,05). Resultados Dos 340 pacientes examinados, 106 (31,2%) se apresentaram com lesões orais potencialmente malignas; destes, 61 (17,9%) biópsias foram realizadas. A lesão mais frequente foi a queilite actínica (37,5%), e o sítio anatômico mais acometido foi o lábio inferior (49,6%). Entre os 106 pacientes da amostra, 48 (45,3%) relataram consumo de nicotina, 35 (33%) ingeriam bebidas alcoólicas e 34 (32,1%) trabalhavam expostos ao sol. Comparando o diagnóstico clínico com o histopatológico, as lesões que apresentaram maior compatibilidade foram a eritroplasia oral e a lesão ulcerada atípica (100% ambas). Conclusão Na maioria dos casos, houve compatibilidade do diagnóstico clínico com o histopatológico. Notou-se correlação entre a ocorrência de eritroplasia, leucoplasia e eritroleucoplasia com o hábito de fumar, e entre a queilite actínica com a exposição solar. A eritroleucoplasia foi a lesão que demonstrou maior grau de malignização neste estudo. Diante do exposto, recomenda-se maior atenção por parte dos cirurgiões-dentistas ao diagnóstico das lesões orais potencialmente malignas, para aplicação da melhor conduta e controle da lesão, impedindo sua transformação maligna.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Precancerous Conditions/pathology , Leukoplakia, Oral/pathology , Mouth Neoplasms/pathology , Cheilitis/pathology , Erythroplasia/pathology , Precancerous Conditions/epidemiology , Brazil/epidemiology , Leukoplakia, Oral/epidemiology , Mouth Neoplasms/epidemiology , Smoking , Cheilitis/epidemiology , Incidence , Cross-Sectional Studies , Retrospective Studies , Risk Factors , Lichen Planus, Oral/pathology , Lichen Planus, Oral/epidemiology , Erythroplasia/epidemiology
15.
Rev. chil. radiol ; 22(4): 158-163, 2016. ilus, tab
Article in Spanish | LILACS | ID: biblio-844622

ABSTRACT

Abstract: Objective. Assess the performance of digital 2D mammography and tomosynthesis in the characterisation of architectural breast distortion (ABD). Material and method. A retrospective study, approved by the Ethics Committee, was conducted on mammographic studies on cases with a diagnosis of ABD selected from August 2015-August 2016. Cases with imaging modalities available on PACS were included: digital mammography (2D), tomosynthesis (TS), ultrasound (US), magnetic resonance (MR), and with biopsy performed at our institution. ABD cases associated with micro-calcifications and post-surgical changes were excluded. Detection rates and imaging characteristics were analysed, as well as the histopathological concordance. Results. A total of 81 cases of ABD without microcalcifications were detected on the mammographs, but only 52 met the inclusion criteria. According to histopathology, 23 (44%) were malignant, 17 (33%) were benign, and 12 (23%) were high-risk lesions. All were detected by TS and US, and classified as suspicious lesions (BI-RADS 4 or 5). In 2D mammography, 24 cases (46%) were not seen and 8 (33%) of these were malignant. Malignant lesions showed dense centres in 87% of cases. The most frequent lesion on ultrasound was a hypoechogenic area (60%) in 86% of lesions with penetrating vessels. A total of 21 MRI were performed, with mass enhancement being identified in all of them. Conclusion. ABD is better displayed in TS than 2D mammography. Despite its characteristics, histological examination is essential (even when a radiolucent centre is observed). Focused US should be the next procedure to follow, since it allows to visualize the lesion to be visualised, and can direct the percutaneous biopsy in most cases.


Resumen: Objetivo. Determinar en qué método de imagen se logra visualizar y caracterizar mejor una distorsión de la arquitectura mamaria (DAM). Material y método. Estudio retrospectivo, aprobado por el Comité de Ética. Se seleccionaron los estudios mamográficos con diagnóstico de DAM en nuestro servicio entre agosto de 2015 y agosto de 2016. Se incluyeron casos estudiados con al menos 3 de las modalidades de imágenes disponibles en PACS: mamografía digital (2D), tomosíntesis (TS), ecografía (US), resonancia (RM) y que fueron biopsiados en nuestra institución. Se excluyeron casos de DAM asociadas con microcalcificaciones y cambios posquirúrgicos. Se evaluaron la tasa de detección, las características imagenológicas y la concordancia histopatológica. Resultados. En 15 meses se detectaron 81 casos de DAM en mamografía; de estos, 52 cumplieron con los criterios de inclusión. Según la histopatología, 23 (44%) resultaron malignas, 17 (33%) benignas y 12 (23%) lesiones de alto riesgo (LAR). Todas fueron detectadas por TS y US, clasificadas como lesiones sospechosas (BI-RADS 4 o 5). En mamografía 2D, 24 casos (46%) quedaron ocultos, y de estos, 8 (33%) resultaron malignos. Las lesiones malignas presentaron centro denso en el 87% de los casos. La lesión más frecuente en ecografía fue el área hipoecogénica (60%), en el 86% de las lesiones con vasos penetrantes. Se contó con 21 RM, identificándose captación tipo masa en las patologías malignas. Conclusión. La DAM es mejor visualizada en TS que en mamografía 2D. Pese a sus características, un estudio histológico es indispensable (incluso al observar un centro radiolúcido). El US dirigido es el paso a seguir, ya que permite visualizar la lesión y dirigir su biopsia percutánea en la mayoría de los casos.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/pathology , Breast/pathology , Carcinoma, Ductal, Breast/diagnostic imaging , Carcinoma, Ductal, Breast/pathology , Mammography , Precancerous Conditions/pathology , Retrospective Studies
16.
Gastroenterol. latinoam ; 27(4): 207-214, 2016. ilus, tab
Article in Spanish | LILACS | ID: biblio-907638

ABSTRACT

Introduction: Gastric cancer (GC) is the leading cause of cancer mortality in Chile. The development ofgastric adenocarcinoma its preceded by a histopathologic cascade composed of gastric atrophy, intestinal metaplasia and gastric dysplasia. Sydney protocol has been proposed as the standard method for diagnosingthese conditions. The aim of this research study was to establish whether Sydney protocol increase thedetection of premalignant gastric lesions, as gastric atrophy and intestinal metaplasia, compared to non protocolizedendoscopies/biopsies. Methods: Upper gastroduodenal endoscopies (GDE) from Hospital Clí-nico Universidad Católica de Chile between April-May 2015 and April-May 2016 was analyzed. Patientswith histological study with 18 years-old or older were included. Patients with history of GC or malignantlesions at GDE where excluded. Detection of gastric atrophy, intestinal metaplasia and suggestive findingsof autoimmune gastritis where compared between Sydney protocol and non-protocolized endoscopies/biopsies...


Introducción: El cáncer gástrico (CG) es la principal causa de muertes por cáncer en Chile. El desarrollo del adenocarcinoma gástrico es precedido por una cascada histopatológica (gastritis; atrofia gástrica/AG; metaplasia intestinal/MI). Se ha propuesto la biopsia del cuerpo, ángulo y antro a través del protocolo de Sydney para la búsqueda de estas condiciones. Objetivo: Determinar la diferencia en la detección delesiones premalignas gástricas a través del protocolo de Sydney comparado con el estudio endoscópico habitual. Métodos: Se analizaron las endoscopias digestivas altas (EDA) realizadas en el Centro de Endoscopia Digestiva del Hospital Clínico de la Universidad Católica en los períodos entre abril y mayo del 2015 y 2016. Se incluyeron las EDA de pacientes mayores de 18 años con estudio histológico. Fueron excluidos los pacientes con antecedente personal de CG o lesiones de aspecto maligno macroscópicas. Se comparó la detección de AG, MI y gastritis autoinmune (GA) en el estudio histológico entre los pacientes con protocolo Sydney y el estudio endoscópico no protocolizado...


Subject(s)
Male , Female , Humans , Adult , Young Adult , Middle Aged , Aged , Aged, 80 and over , Biopsy/methods , Precancerous Conditions/pathology , Stomach Neoplasms/pathology , Atrophy/pathology , Chile , Clinical Protocols , Endoscopy, Digestive System , Helicobacter Infections/pathology , Metaplasia/pathology , Retrospective Studies
17.
Braz. j. infect. dis ; 19(6): 557-562, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769630

ABSTRACT

ABSTRACT OBJECTIVE: The goal of this study was to determine the prevalence of human papillomavirus infection infection and cervical lesions and its associated factors among HIV infected women attending an AIDS clinic in Amazonas state, Brazil. METHODS: Cross-sectional study. Women attending an AIDS clinic in the city of Manaus between March and December 2011 for gynecological examination were invited to participate. Enrolled patients answered a standardized interview including demographical, behavioral, and clinical data. Additionally, patients underwent a gynecological evaluation with collection of cervical samples for cytological analysis and high-risk human papillomavirus infection hybrid capture. A blood sample was also obtained to determine CD4 and viral load levels. RESULTS: A total of 310 (82.9%) women participated in the study. High-risk human papillomavirus infection was detected in 191 (61.6%) cases; 24 (13.5%) had low-grade squamous intraepithelial lesion (SIL) and 4 (2.2%) high-grade SIL. No invasive cervical cancer was diagnosed. Median age was 32 (interquartile range (IQR): 27-38) years and median of education was 8.5 (IQR 4-11) years of schooling and 56.1% had a monthly income up to US$180. In multivariate analysis, being less than 30 years old [OR = 1.7 (95% CI: 1.2-2.4,p = 0.005)], high-grade SIL [OR = 6.5 (95% CI: 1.6-23.0, p = 0.009)], and CD4 counts <200 cells/mm3 [OR = 1.6 (95% CI: 1.2-2.0, p < 0.001)] were associated with high risk human papillomavirus infection infection. CONCLUSIONS: In the present study high-risk human papillomavirus infection was frequent and it was associated to high-SIL. These results show the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.


Subject(s)
Adolescent , Adult , Female , Humans , Middle Aged , Young Adult , HIV Infections/complications , Papillomavirus Infections/epidemiology , Uterine Cervical Neoplasms/epidemiology , Brazil/epidemiology , Cross-Sectional Studies , DNA, Viral/analysis , Papanicolaou Test , Prevalence , Papillomavirus Infections/complications , Precancerous Conditions/epidemiology , Precancerous Conditions/pathology , Precancerous Conditions/virology , Risk Factors , Socioeconomic Factors , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Viral Load
18.
Braz. j. med. biol. res ; 48(11): 1039-1047, Nov. 2015. tab, graf
Article in English | LILACS | ID: lil-762910

ABSTRACT

We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia, squamous metaplasia, moderate dysplasia, adenomatous hyperplasia, severe dysplasia, squamous cell carcinoma and adenocarcinoma. Matched lung parenchyma tissue samples included 25 squamous cell carcinomas and 31 adenocarcinomas. Immunohistochemistry was performed to analyze for the distribution of hyaluronidase (Hyal)-1 and −3, and hyaluronan synthases (HAS)-1, −2, and −3. Hyal-1 showed significantly higher expression in basal cell hyperplasia than in moderate dysplasia (P=0.01), atypical adenomatous hyperplasia (P=0.0001), or severe dysplasia (P=0.03). Lower expression of Hyal-3 was found in atypical adenomatous hyperplasia than in basal cell hyperplasia (P=0.01) or moderate dysplasia (P=0.02). HAS-2 was significantly higher in severe dysplasia (P=0.002) and in squamous metaplasia (P=0.04) compared with basal cell hyperplasia. HAS-3 was significantly expressed in basal cell hyperplasia compared with atypical adenomatous hyperplasia (P=0.05) and severe dysplasia (P=0.02). Lower expression of HAS-3 was found in severe dysplasia compared with squamous metaplasia (P=0.01) and moderate dysplasia (P=0.01). Epithelial Hyal-1 and −3 and HAS-1, −2, and −3 expressions were significantly higher in pre-neoplastic lesions than in neoplastic lesions. Comparative Cox multivariate analysis controlled by N stage and histologic tumor type showed that patients with high HAS-3 expression in pre-neoplastic cells obtained by lung/bronchial biopsy presented a significantly higher risk of death (HR=1.19; P=0.04). We concluded that localization of Hyal and HAS in lung/bronchial pre-neoplastic and neoplastic lesions was inversely related to malignancy, which implied that visualizing these factors could be a useful diagnostic procedure for suspected lung cancer. Finalizing this conclusion will require a wider study in a randomized and prospective trial.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Bronchial Neoplasms/enzymology , Carcinoma, Squamous Cell/enzymology , Glucuronosyltransferase/metabolism , Hyaluronoglucosaminidase/metabolism , Lung Neoplasms/enzymology , Neoplasm Proteins/metabolism , Precancerous Conditions/enzymology , Bronchial Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Cell Adhesion Molecules/analysis , Hyaluronoglucosaminidase/analysis , Hyperplasia/enzymology , Immunohistochemistry , Kaplan-Meier Estimate , Lung Neoplasms/pathology , Multivariate Analysis , Metaplasia/enzymology , Prognosis , Precancerous Conditions/pathology , Severity of Illness Index , Statistics, Nonparametric
19.
Rev. argent. coloproctología ; 26(2): 45-53, jul. 2015. tab
Article in Spanish | LILACS | ID: biblio-973149

ABSTRACT

Introducción: El carcinoma anal escamoso (CAE) representa el 2% de todas las neoplasiascolorrectoanales. Afecta a 2/100.000 habitantes por año en la población general. Se incrementa en lospacientes con serología positiva para el virus de la inmunodeficiencia humana (VIH-positivos), 60/100.000habitantes por año y asciende a 92-144/100.000 habitantes por año en los hombres que tienen sexocon hombres (HSH) VIH-positivos. Al igual que en el carcinoma escamoso del cuello uterino, el virus delpapiloma humano (VPH) está implicado en su génesis, y se encuentra presente en el 92% de los casos.El cáncer cervical y anal comparten el mismo origen embriológico, formando la zona de transformación,sitio donde se desarrollan las lesiones intraepiteliales escamosas (SIL) como resultado de la infección ypersistencia del VPH, en especial de los genotipos de alto riesgo que pueden progresar a CAE invasor. Elaumento significativo de CAE en las últimas décadas ha llevado a desarrollar la pesquisa de SIL anal (ASIL)mediante citología (PAP) y anoscopía de alta resolución (AAR) con técnica colposcópica, emulando losprotocolos de detección temprana para prevención el cáncer de cuello uterino.Objetivo: Conocer prevalencia de lesiones precursoras del CAE. Determinar sensibilidad (S), especificidad (E),valor predictivo positivo (VPP) y negativo (VPN) del PAP para la detección de displasias en población de riesgo.Material y Método: Diseño: Prospectivo, transversal, observacional, analítico. Se incluyeron individuos dealto riesgo (VIH-positivos, HSH, individuos con historia de VPH anogenital, mujeres con antecedentes decáncer o neoplasia intraepitelial genital inferior) estudiados en forma consecutiva, entre abril 2012 y febrero2014, en Consultorio de Detección Temprana del Cáncer Ana...


Introduction: Anal squamous cell carcinoma (SCC) represents 2% of all colo-recto-anal malignancies. It is confirmed a higher rate of anal cancer among HIV-infected population in comparison with the HIVuninfected population (60/100,000 person-years, versus 2/100,000 person-years). Among HIV-infected men who have sex with men (MSM), the incidence of anal cancer is as high as 92-144/100,000 population. Like cervical cancer, squamous-cell canal cancer is caused predominantly by high-risk, oncogenic strains of human papillomaviruses (HPV) detected in 92% of HIV-positive MSM. The cervical and anal cancer share the same embryological origin, and occurs at a squamo-columnar transition zone, site of squamous intraepithelial lesions (SIL) as a result of the persistence HPV infection, especially the high-risk genotypes that may progress to invasive cancer. In the last decades, the incidence of squamous-cell anal carcinoma is increasing rapidly forcing the research of anal SIL (ASIL) cytology (PAP) and high-resolution anoscopy (HRA) colposcopic technique, emulating protocols for early detection of cervical cancer as a primary prevention. Objective: This study aimed to determine the prevalence of SCC precursor lesions. Determine sensitivity (S), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) for the detection of anal dysplasia in the risk population. Material and Methods: Design prospective, cross-sectional, observational, analytical study. High-risk patients (HIV-positive MSM, patients with history of anogenital HPV, women with history of cancer or lower genital intraepithelial neoplasia) were included consecutively between April 2012 and February 2014 in Anal Early Detection Cancer Clinic...


Subject(s)
Male , Female , Humans , Adult , Young Adult , Middle Aged , Anus Neoplasms/diagnosis , Anus Neoplasms/prevention & control , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/prevention & control , Squamous Intraepithelial Lesions of the Cervix/diagnosis , Papanicolaou Test , Proctoscopy/methods , Anal Canal/cytology , Anal Canal/injuries , Precancerous Conditions/diagnosis , Precancerous Conditions/pathology , Sensitivity and Specificity , Predictive Value of Tests , Risk Factors , Cross-Sectional Studies , Prospective Studies , Observational Studies as Topic
20.
Arq. bras. cardiol ; 104(6): 487-491, 06/2015. tab
Article in English | LILACS | ID: lil-750704

ABSTRACT

Background: Cardiovascular diseases affect people worldwide. Individuals with Down Syndrome (DS) have an up to sixteen-time greater risk of mortality from cardiovascular diseases. Objective: To evaluate the effects of aerobic and resistance exercises on blood pressure and hemodynamic variables of young individuals with DS. Methods: A total of 29 young individuals with DS participated in the study. They were divided into two groups: aerobic training (AT) (n = 14), and resistance training (TR) (n = 15). Their mean age was 15.7 ± 2.82 years. The training program lasted 12 weeks, and had a frequency of three times a week for AT and twice a week for RT. AT was performed in treadmill/ bicycle ergometer, at an intensity between 50%-70% of the HR reserve. RT comprised nine exercises with three sets of 12 repetition-maximum. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and hemodynamic variables were assessed beat-to-beat using the Finometer device before/after the training program. Descriptive analysis, the Shapiro-Wilk test to check the normality of data, and the two-way ANOVA for repeated measures were used to compare pre- and post-training variables. The Pearson’s correlation coefficient was calculated to correlate hemodynamic variables. The SPSS version 18.0 was used with the significance level set at p < 0.05. Results: After twelve weeks of aerobic and/or resistance training, significant reductions in variables SBP, DBP and MBP were observed. Conclusion: This study suggests a chronic hypotensive effect of moderate aerobic and resistance exercises on young individuals with DS. .


Fundamento: As doenças cardiovasculares atingem as pessoas em todo o mundo. Pessoas com Síndrome de Down (SD) apresentam um risco até dezesseis vezes maior de mortalidade por doenças cardiovasculares. Objetivo: Avaliar os efeitos do exercício aeróbio e resistido na pressão arterial e variáveis hemodinâmicas de jovens com SD. Métodos: Participaram do estudo 29 jovens com SD, divididos em dois grupos: (TA) Treinamento Aeróbio (n = 14) e (TR) Treinamento Resistido (n = 15), idade 15,7 ± 2,82 anos. O programa de treinamento teve doze semanas, frequência de três vezes por semana para TA, e duas vezes, para TR. TA foi realizado com esteira/bicicleta, intensidade entre 50%-70% da FC de reserva. TR teve nove exercícios com três séries de doze repetições máximas. Avaliações de Pressão Arterial Sistólica (PAS), Pressão Arterial Diastólica PAD), Pressão Arterial Média (PAM) e variáveis hemodinâmicas foram realizadas batimento a batimento por meio do Finometer antes/após o programa de treinamento. Foram usados estatística descritiva, teste de Shapiro-Wilk para verificação da normalidade dos dados e teste ANOVA two-way para medidas repetidas para a comparação das variáveis pré e pós-treinamento. Para correlacionar as variáveis hemodinâmicas, foi calculado o coeficiente de correlação de Pearson. Utilizou-se o programa estatístico SPSS versão 18.0, adotando nível de significância (p < 0,05). Resultados: Após doze semanas de treinamento, aeróbio e/ou resistido, ocorreram reduções significativas pós‑intervenção nas variáveis de PAS, PAD e PAM. Conclusão: Sugere um efeito hipotensivo crônico do exercício aeróbio e resistido moderado em jovens com SD. .


Subject(s)
Humans , Biometry/methods , Colorectal Neoplasms/epidemiology , Colorectal Neoplasms/pathology , Data Interpretation, Statistical , Databases, Factual , Diagnosis, Computer-Assisted/methods , Precancerous Conditions/epidemiology , Precancerous Conditions/pathology , Computer Simulation , Models, Biological , Models, Statistical , Signal Processing, Computer-Assisted , Statistics as Topic
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