Aspectos genéticos e imagenológicos de la enfermedad quística renal en pediatría: serie de casos / Genetic and radiological aspects of pediatric renal cystic disease: A case series

Las enfermedades quísticas renales son condiciones frecuentes cuya etiología puede ser muy heterogénea, por lo que se requiere un adecuado abordaje para su diagnóstico y manejo. El objetivo de este trabajo fue ilustrar parte del espectro de la enfermedad renal quística por medio de casos clínicos manejados en la Fundación Valle del Lili. Se describen 11 casos clínicos que incluyen enfermedades como displasia multiquística renal, enfermedad poliquística renal autosómica dominante y autosómica recesiva, entre otras. Las enfermedades quísticas renales varían en su presentación clínica, historia natural, hallazgos imagenológicos, bases genéticas y fisiopatológicas, por consiguiente, el enfoque diagnóstico y el manejo integral se debe realizar de forma individualizada y con un abordaje multidisciplinario.

Renal cystic diseases are common conditions whose etiology can be highly heterogeneous. They require a correct approach for adequate diagnosis and management. We aimed to illustrate part of the spectrum of renal cystic diseases through some clinical cases managed in our service. We describe 11 clinical cases including clinical entities such as renal multicystic dysplasia, and autosomal dominant and autosomal recessive polycystic renal disease, among other pathologies. Renal cystic diseases are heterogeneous in their clinical presentation, natural history, radiological findings, and genetic and pathophysiological basis. An integral clinical approach is needed to get a clear etiological diagnosis and offer adequate individualized care and follow-up for patients.

La profesora Raquel Pérez González y el signo de la muela de cangrejo / Professor Raquel Pérez González and crab claw sign

La Dra. Raquel Pérez González, más conocida entre colegas, alumnos y compañeros de trabajo por "la profe Raquel", obtuvo el título de Medicina en el año 1976. Comenzó por vía directa la residencia de Radiología y obtuvo el título de especialista de primer grado en 1979. Se convirtió así, el Hospital Militar Central "Dr. Carlos J. Finlay", en la cuna de su formación profesional y en años posteriores, en la casa que la vio crecer, especialmente como maestra de numerosas generaciones de radiólogos e imagenólogos. Hoy reposan en el jardín del Departamento de Imagenología, parte de sus cenizas, custodiadas por el amor que fue capaz de cultivar. En el 2016, una paciente femenina de 60 años de edad, acudió a la consulta de gastroenterología, con dolor abdominal difuso. La radiografía de abdomen simple, anteroposterior, en posición acostado mostró, una imagen en "muela de cangrejo", visible al tomar el aire dentro del hemicolon transverso izquierdo, como contraste, el cual bordea por ese lado parcialmente, una opacidad de partes blandas, que se extiende desde el mesogastrio, hasta la fosa ilíaca derecha, donde se observa el signo del menisco. Los estudios de imágenes realizados, evidenciaron signos radiológicos típicos de invaginación por causa tumoral maligna. En varias ocasiones, la profesora Raquel utilizó la imagen de este caso, como pregunta en exámenes de promoción de residentes. La publicación de este caso constituye un homenaje a quien será siempre un paradigma de docente.

Dr. Raquel Pérez González, better known among colleagues, students and co-workers as "professor Raquel", obtained her degree in Medicine in 1976. She began her Radiology residency directly and obtained the title of first-class specialist degree in 1979. Thus, the Central Military Hospital "Dr. Carlos J. Finlay" is the cradle of her professional training and in later years, in her home where she saw her grow up, especially as a teacher to numerous generations of radiologists and imaging scientists. Today, part of her ashes rest in the garden of the Imaging Department, guarded by the love that she was able to cultivate. In 2016, a 60-year-old female patient attended the gastroenterology clinic with diffuse abdominal pain. The simple, anteroposterior abdominal x-ray, in the lying position, showed a "crab claw" image, visible when breathing into the left transverse hemicolon, as contrast, which partially borders on that side, a soft tissue opacity, which extends from the mesogastrium to the right iliac fossa, where the meniscus sign is observed. The imaging studies performed showed typical radiological signs of invagination due to malignant tumor. On several occasions, Professor Raquel used the image of this case as a question in resident promotion exams. The publication of this case constitutes a tribute to someone who will always be a paradigm of a teacher.

Inteligência artificial aplicada aos exames de imagem odontológicos: uma revisão da literatura / Artificial intelligence applied to dental imaging: a review

Objetivo: investigar a literatura relacionada à aplicação e desempenho da Inteligência Artificial (IA) em exames de imagem odontológicos. Revisão de literatura: foram incluídos 70 trabalhos experimentais e revisões sistemáticas da literatura, publicados em inglês, no período entre 2018 e 2021, que analisaram a aplicabilidade da IA na detecção automática de: pontos cefalométricos, lesões de cárie, lesões apicais, perda óssea periodontal, sistemas de implantes, cistos e tumores odontogênicos, osteoporose, sinusite maxilar, terceiros molares e canal mandibular, ateromas em carótida, fratura radicular vertical, osteoartrite em articulação temporomandibular, avaliação de morfologia radicular e numeração dentária. Resultados:58,73% dos trabalhos analisados mostrou acurácia diagnóstica acima de 80% com a utilização de IA. Discussão: A maior limitação encontrada foi em relação à aquisição de amostras em quantidade suficiente para treinamento e teste dos modelos, já que imagens radiográficas têm sua disponibilidade limitada por questões éticas e legais relativas aos pacientes e Instituições. A falta de padronização na segmentação e processamento das imagens foi outro fator a influenciar os resultados obtidos, dificultando comparação e generalização. Apesar disso, diversos estudos apresentaram sugestões ou possíveis aperfeiçoamentos para pesquisas futuras, de forma a reduzir estas limitações. Conclusão: A aplicação da IA no diagnóstico por imagens mostrou-se promissora nas diversas áreas pesquisadas, com desempenhos muito semelhantes ou mesmo superiores, muitas vezes, ao desempenho dos profissionais humanos. Contudo, para a legitimação de sua utilização como parte do fluxo de trabalho na clínica, limitações ainda presentes devem ser superadas, especialmente no treinamento dos algoritmos para obtenção de melhores valores de acurácia.

Aim:to investigate the literature related to the application and performance of Artificial Intelligence (AI) in the analysis of dental imaging. Literature review: 70 experimental studies and systematic literature reviews published in English between 2018 and 2021 were included, which analyzed the applicability of AI models in the automatic detection of the following: cephalometric landmarks, dental caries, periapical diseases, alveolar bone loss, dental implant, odontogenic cysts and tumors, osteoporosis, maxillary sinusitis, third molars and mandibular canal, carotid atheromas, vertical root fracture, osteoarthritis in temporomandibular joint, evaluation of root morphology and numbering of dental elements. Results: 58.73% of the analyzed studies showed diagnostic accuracy above 80%.Discussion:the greatest methodological limitation was the acquisition of samples in sufficient quantity for training and testing phases, since radiographic images are limited to their availability due to ethical and legal issues related to patients and institutions. Lack of standardization in the segmentation and image processing was another factor to influence the results, which was difficult to compare and generalize. Despite this, several studies presented suggestions or possible improvements for future research, in order to reduce the impact of these limitations. Conclusion:the investigation of the applicability of AI in theanalysis of dental radiographic images seems to be still in its early days. The implementation of AI tools as radiologists'auxiliaries in their daily practice depends on overcoming the limitations of current studies and obtaining better diagnostic accuracy indices in future evaluations.

Ecografía Inteligente / Intelligent Ultrasound

Tras leer con atención y detenimiento el artículo de revisión Impacto de la Inteligencia Artificial en la Radiología escrito por D. Dannier Iglesias,1 nos gustaría aportar una visión ampliada sobre un área en particular que ha recibido atención insuficiente: la aplicación de la inteligencia artificial (IA) en la imagen diagnóstica de ultrasonido. Aunque se hace una breve referencia a la ecografía en la modalidad de elastografía cuando se comenta un estudio que analiza la detección de fibrosis hepática mediante tomografía computerizada,2 nos sorprendió la ausencia de una discusión en profundidad sobre los casos de éxito en el campo del ultrasonido, ya que se encuentra en una posición privilegiada para beneficiarse de los avances en IA. La Radiología ha sabido integrar los avances en Visión por Computador y Aprendizaje Profundo al mismo ritmo que se han ido produciendo en otros campos de aplicación más alejados de la Medicina, y la imagen de ultrasonido no es la excepción.3 Las ventajas de la ecografía frente a otras modalidades de imagen clínica son evidentes: la ausencia de radiación ionizante, su naturaleza no invasiva, la capacidad de proporcionar imágenes en tiempo real y medición de la velocidad de los fluidos internos han popularizado esta técnica en numerosas especialidades médicas. En comparación con modalidades como la resonancia magnética o la tomografía computarizada, los dispositivos de ultrasonido son significativamente más económicos y no requieren una infraestructura especial. Su popularidad ha llevado a una drástica disminución en el tamaño, peso, consumo energético y coste económico de estos dispositivos en las últimas décadas.4 Es precisamente su portabilidad la que ha favorecido el uso clínico del ultrasonido más allá de las paredes...(AU)

El renacimiento tecnológico de la Radiología: la revolución open source y la inteligencia artificial / The Technological Renaissance of Radiology: The Open Source Revolution and Artificial Intelligence

El campo de la radiología ha experimentado avances notables en las últimas décadas, con desarrollos que van desde la mejora de la calidad y digitalización de las imágenes hasta la detección asistida por computadora. Particularmente, la aparición de técnicas de Inteligencia Artificial basadas en Deep Learning y Visión Computacional han promovido soluciones innovadoras en el diagnóstico y el análisis radiológico. Se explora la relevancia de los desarrollos y modelos open source en el progreso de estas técnicas, resaltando el impacto que la colaboración y el acceso abierto han tenido en el avance científico del campo. La investigación tiene un enfoque cualitativo, con alcance descriptivo y retrospectivo, de corte longitudinal. Se realizó un análisis documental de la evolución y el impacto del open source en la Radiología, poniendo de relieve la colaboración multidisciplinar. Se examinaron casos de uso, ventajas, desafíos y consideraciones éticas en relación con la implementación de soluciones basadas en Inteligencia Artificial en Radiología. El enfoque open source ha mostrado ser una influencia positiva en la Radiología, con potencial para influir en la atención médica, ofreciendo soluciones más precisas y accesibles. No obstante, se presentan desafíos éticos y técnicos que requieren atención(AU)

The field of radiology has seen notable advances in recent decades, with developments ranging from image quality improvement and digitization to computer-aided detection. Particularly, the emergence of Artificial Intelligence techniques based on Deep Learning and Computer Vision have promoted innovative solutions in diagnosis and radiological analysis. This article explores the relevance of open source developments and models in the progress of these techniques, highlighting the impact that collaboration and open access have had on the scientific advancement in this field. This research has a qualitative approach, with a descriptive, retrospective, longitudinal scope. A documentary analysis of the evolution and impact of open source in Radiology was carried out, highlighting multidisciplinary collaboration. Use cases, advantages, challenges and ethical considerations were also examined in relation to the implementation of AI-based solutions in Radiology. The Open Source approach has been shown to be a positive influence in Radiology, with the potential to influence medical care, offering more precise and accessible solutions. However, there are ethical and technical challenges that require attention(AU)

Comparación de las características anatómicas del conducto nasopalatino en pacientes dentados y desdentados mediante tomografía computarizada de haz cónico. Lima 2018-2020 / Comparison of the anatomic characteristics of the nasopalatine duct in toothed and edentulous patients by cone beam computed tomography. Lima 2018-2020

Objetivo : Comparar las características anatómicas del CNP en pacientes dentados y desdentados mediante Tomografía Computarizada de Haz Cónico (TCHC) del Servicio de Radiología Bucomaxilofacial realizadas en el Centro Dental Docente de la Universidad Peruana Cayetano Heredia. Material y métodos : Se evaluaron todas las TCHC adquiridas entre los años 2018 y 2020, que cumplan con ciertos criterios; donde se comparó las características anatómicas del CNP. Los datos fueron registrados en una base de datos, luego representados en tablas. Resultados : Se evaluaron 216 volúmenes tomográficos (VT), divididos en dos grupos: dentados y desdentados. La forma cilíndrica y la forma de canal único fueron las más encontradas en ambos grupos. La longitud y la distancia fueron mayores en pacientes dentados, no se encontró asociación con relación al diámetro; la inclinación fue mayor en pacientes desdentados, encontrándose asociación con relación a la inclinación entre los grupos comparados. Conclusiones : Se encontraron múltiples diferencias anatómicas del CNP entre los pacientes dentados y desdentados evaluados con TCHC con relación al sexo y la edad.

Objective : To compare the anatomical characteristics of the NPC in dentate and edentulous patients using Cone Beam Computed Tomography (CBCT) of the Bucomaxillofacial Radiology Service performed at the Centro Dental Docente of the Universidad Peruana Cayetano Heredia. Material and methods : All TCHC acquired between the years 2018 and 2020, which meet certain criteria, were evaluated; where the anatomicals characteristics of the CNP were compared. The data were recorded in a database, then represented in tables. Results : 216 tomographic volumes were evaluated, divided into two groups: dentate and edentulous. The single cylindrical shape and the single channel shape were the most found in both groups. The length and distance were greater in dentate patients, no association was found in relation to the diameter, the inclination was greater in edentulous patients, finding an association in relation to the inclination between the compared groups. Conclusions : Multiple anatomical differences of the CNP were found between the dentate and edentulous patients evaluated with TCHC in relation to sex and age.

Diagnostic Value of American Thyroid Association Guidelines,American College of Radiology Thyroid Imaging Reporting and Data System,and Chinese Thyroid Imaging Reporting and Data System Alone and Combined With BRAFV600E Mutation in Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance / 中国医学科学院学报

Objective To explore the diagnostic efficacy of American Thyroid Association(ATA)guidelines,American College of Radiology Thyroid Imaging Report and Data System(ACR-TIRADS),and Chinese Thyroid Imaging Reporting and Data System(C-TIRADS)alone and combined with BRAFV600E mutation in atypia of undetermined significance/follicular lesion of undetermined significance(AUS/FLUS).Methods A total of 138 patients who underwent ultrasound-guided fine needle aspiration(FNA)in the Chinese PLA General Hospital from January 2020 to May 2023 were selected.The clinicopathological and ultrasound characteristics were retrospectively analyzed for each nodule.Each nodule underwent preoperative BRAFV600E mutation testing and was diagnosed according to the ATA guidelines,ACR-TIRADS,and C-TIRADS.The diagnostic efficacy of ATA guidelines,ACR-TIRADS,and C-TIRADS alone and combined with BRAFV600E mutation was assessed based on the results of histopathological diagnosis.Results The 138 AUS/FLUS thyroid nodules included 45(32.6%)benign ones and 93(67.4%)malignant ones.The patient age(t=1.444,P=0.151),gender(χ2=0.259,P=0.611),and location of nodules(χ2=2.055,P=0.358)had no statistical significance for the differentiation between benign and malignant nodules,while nodule size(Z=2.500,P=0.012),echo(χ2=14.693,P<0.001),composition(χ2=17.075,P<0.001),aspect ratio ≥1(χ2=9.477,P=0.002),and microcalcification(χ2=6.892,P=0.009)were of significance for the differentiation.When applied alone,BRAFV600E mutation showed high specificity(95.56%)and positive predictive value(95.65%).Among the three ultrasound grading systems,ACR-TIRADS had the highest sensitivity(χ2=37.923,P<0.001;χ2=40.462,P<0.001)and accuracy(χ2=81.595,P<0.001;χ2=76.912,P<0.001),while C-TIRADS had the highest specificity(χ2=11.746,P<0.001;χ2=21.235,P<0.001).However,the three systems showed no statistically significant difference in the diagnostic efficiency when applied alone(Z=1.177,P=0.239;Z=0.213,P=0.831;Z=1.016,P=0.310).The combination of BRAFV600E mutation with ACR-TIRADS or C-TIRADS improved the diagnostic efficacy of BRAFV600E mutation in distinguishing the benign and malignant AUS/FLUS nodules(Z=2.107,P=0.035;Z=2.752,P=0.006).The combination of ATA guidelines with BRAFV600E mutation increased the diagnostic accuracy of BRAFV600E mutation(χ2=20.679,P<0.001),while it had no statistically significant difference in distinguishing the benign and malignant AUS/FLUS nodules(Z=1.321,P=0.186).The combination of ATA guidelines,ACR-TIRADS,or C-TIRADS with BRAFV600E mutation improved the diagnostic efficacy of ultrasound grading systems for AUS/FLUS nodules(Z=2.770,P=0.006;Z=2.770,P=0.006;Z=2.890,P=0.004).Specifically,ACR-TIRADS combined with BRAFV600E mutation showed the highest sensitivity(χ2=4.712,P=0.030;χ2=4.712,P=0.030),while C-TIRADS combined with BRAFV600E mutation showed the highest accuracy(χ2=77.627,P<0.001;χ2=85.827,P<0.001).However,there were no statistically significant differences in diagnostic performance between the combinations(Z=1.276,P=0.202;Z=0.808,P=0.419;Z=1.615,P=0.106).Conclusion ATA guidelines,ACR-TIRADS,and C-TIRADS combined with BRAFV600E mutation can improve the diagnostic efficacy of BRAFV600E mutation or ultrasound grading system alone in AUS/FLUS nodules,which can facilitate the further management and treatment of such patients.

Avaliação clínica e epidemiológica de sarcomas: estudo retrospectivo de base de registro hospitalar de câncer do Estado de São Paulo / Clinical and epidemiological evaluation of Sarcomas: a retrospective study based on the hospital cancer registry in the State of São Paulo

Introdução: Os sarcomas são tumores raros e heterogêneos com origem mesenquimal. Atualmente são reconhecidos mais de 80 subtipos histológicos distintos. O tratamento compreende cirurgia, radioterapia e quimioterapia. A taxa de recidiva tumoral após a cirurgia e a sobrevida variam de acordo com o subtipo, graus histológicos e o estádio TNM. Por ser uma neoplasia rara, há inúmeras barreiras para o adequado diagnóstico e tratamento dos sarcomas.Objetivos: avaliar as características sociodemográficas e clínicas de pacientes com sarcomas tratados no estado de São Paulo. Objetivos secundários: Avaliar a frequência de sarcomas de partes moles no estado de São Paulo, as características sociodemográficas e clínicas, avaliar os padrões de tratamento, analisar a sobrevida global dos pacientes, analisar possíveis fatores prognósticos relacionados com a sobrevida. Metodologia: estudo observacional, de coorte retrospectiva, descritivo, de pacientes com diagnóstico de Sarcomas de Partes moles identificados na rede de registros hospitalares de câncer do Estado de São Paulo, Brasil, no período de 2008 a 2018. Foram analisadas variáveis sociodemográficas (sexo, idade, grau de escolaridade, tipo de instituição de tratamento e sistema de saúde), tempo do diagnóstico até o início do tratamento, subtipo histológico, localização do tumor primário, estadiamento TNM e tipo de tratamento empregado (cirurgia, radioterapia, quimioterapia e combinações). Foi realizada uma análise descritiva das variáveis, descrevendo as distribuições de frequência absoluta (n) e relativa (%) para as variáveis qualitativas, e as principais medidas resumo, como a média, desvio padrão, mediana, valores mínimo e máximo para as variáveis quantitativas. Para avaliar a associação entre variáveis qualitativas, foi utilizado o teste qui-quadrado ou o teste exato de Fisher, quando apropriado. A sobrevida global foi estimada pelo método de Kaplan Meier e a comparação entre as curvas de sobrevida foi feita pelo teste de log-rank. O modelo de regressão de Cox foi empregado para identificar variáveis relacionadas com o prognóstico. Adotou-se valor de significância de p de 0,05. Resultados foram incluídos na análise 3626 pacientes. A idade média foi de 51 anos (18-99 anos). Houve um discreto predomínio do sexo feminino (50,2%). A minoria tinha nível de ensino superior (10%), o tratamento ocorreu no SUS em 63,4% e na capital em 54,7% e 58,2% iniciaram o tratamento em menos de 60 dias. Houve predomínio de lipossarcoma e leiomiossarcoma (17,9% e 15,0%, respectivamente) e 45,8% tinham tumor nas extremidades e 31,5% no retroperitôneo. De acordo com o TNM, houve 6,4% estádio IA, 11,5% IB, 3,9% IIA, 6,1% IIB, 22% III, 20,8% IV, 11,3% X e 18,0% Y. Cirurgia, radioterapia e quimioterapia foram empregadas em 70,1%, 32,2% e 43,9%, respectivamente. Os pacientes tratados no SUS tiveram maior tempo para início do tratamento (76 x 58 dias, p <0,001) e foram tratados com menos cirurgia e radioterapia (68,7%x77,2%, p <0,001 e 31,8% x 37,2%, p 0,012, respectivamente). A sobrevida global mediana foi de 49 meses e a sobrevida global em 1, 2 e 5 anos foi de 76%, 63% e 46%, respectivamente. Na análise multivariada de Cox idade, local de tratamento, nível de escolaridade e sexo foram variáveis independentes para sobrevida global. Conclusão: Identificamos que houve atraso no início do tratamento após o diagnóstico para uma grande parcela dos pacientes. Além disso, encontramos discrepância significativa no tempo para início do tratamento de acordo com o sistema atendimento. Os pacientes do sistema público de saúde tiveram maior tempo para iniciar o tratamento. Nossos achados apontam para a existência de disparidades no sistema de saúde e reforçam a necessidade de mais estudos para entender melhor as barreiras enfrentadas pelos pacientes com diagnóstico de sarcomas.

Introduction: Sarcomas are rare and heterogeneous tumors with mesenchymal origin. Treatment includes surgery, radiotherapy, and chemotherapy. The tumor recurrence rate after surgery and survival varies according to the histological subtype. More than 80 distinct histological subtypes are currently recognized. Because it is a rare neoplasm, there are numerous barriers to proper diagnosis and treatment. Objectives: evaluation of sociodemographic and clinical characteristics of patients with sarcomas treated in the state of São Paulo. Secondary objectives: To evaluate the frequency of soft tissue sarcomas in the state of São Paulo, socio-demographic and clinical characteristics, evaluate treatment standards, analyze the overall survival of patients, and analyze possible prognostic factors related to survival. Methodology: observational, cohort, descriptive, retrospective study of patients diagnosed with soft tissue sarcomas identified in the network of hospital cancer registries in the state of São Paulo, Brazil, from 2008 to 2018. Socio demographic variables were analyzed (gender, age, educational level, type of treatment institution, health system), time from diagnosis to start of treatment, histological subtype, primary tumor location, tumor size, TNM staging, type of treatment employed (surgery, radiotherapy, chemotherapy and combinations). Statistical analysis: a descriptive analysis of the variables was performed, describing the absolute (n) and relative (%) frequency distributions for the qualitative variables, and the main summary measures, such as mean, standard deviation, median, minimum and maximum values were calculated. To assess the association between qualitative variables, the chi-square test or Fisher's exact test were used when appropriate. Overall survival was estimated using the Kaplan-Meier method and a comparison between survival curves was performed using the logrank test. A significance value of p value of 0.05 was adopted. Results: A total of 3626 patients were included in the analysis. The median age was 51 years (range 18 to 99 years). There was a slight predominance of females (50.2%). The minority had a higher education level (10%); the treatment took place in the public health care system (SUS) in 63.4% and in the capital in 54.7%, and 58.2% started treatment in less than 60 days. There was a predominance of liposarcoma and leiomyosarcoma (17,9.4% and 15.0%, respectively) and 45.8% had tumor in the extremities and 31.5% in the retroperitoneum. According to the TNM, there were 6.4% stage IA, 11.5% IB, 3.9% IIA, 6.1% IIB, 22% III, 20.8% IV, 11.3% X and 18.0% Y. Surgery, radiotherapy and chemotherapy were used in 70.1%, 32.2% and 43.9%, respectively. Patients treated at SUS had a longer time to start treatment (76 x 58 days, p <0.001) and were treated with less surgery and radiotherapy (68.7% x 77.2%, p <0.001 and 31.8% x 37.2%, p 0.012, respectively). The median overall survival was 49 months and the overall survival at 1, 2 and 5 years was 76%, 63% and 46%, respectively. In Cox's multivariate analysis, age, sex, educational level and local of treatment were independent variables for overall survival. Conclusion: We identified that there was a delay in starting treatment after diagnosis for a large proportion of patients. Furthermore, we found a significant discrepancy in the time to start treatment according to the care system. Patients in the public health system had longer time to start treatment. Our findings point to the existence of disparities in the healthcare system and reinforce the need for more studies to better understand the barriers faced by patients diagnosed with sarcomas.

Calidad radiográfica obtenida por estudiantes de Odontología mediante la técnica de bisectriz / Radiographic quality obtained by dental students using the bisecting angle technique

Objetivo: Evaluar la calidad radiográfica mediante técnica de la bisectriz ejecutada por estudiantes de Odontología de tercer año. Material y Método: Estudio observacional descriptivo. Se evaluaron 220 radiografías ejecutadas por 55 estudiantes de Odontología de tercer año. La calidad radiográfica fue evaluada por dos investigadores, mediante una pauta creada con cuatro parámetros: posición de la película, angulación horizontal, angulación vertical y rayos X centrado. Fue comparada la calidad según sector radiográfico, anterior y posterior. Se realizó estadística descriptiva y prueba de chi-2 para establecer diferencias entre calidad y sector radiográfico, con un valor de significancia estadística de p0.05. Conclusión: Las radiografías periapicales tomadas mediante técnica de la bisectriz por estudiantes de Odontología de tercer año, son mayoritariamente de calidad inaceptable, sin diferencias significativas entre sectores.

Objective: To evaluate radiographic quality using the bisecting angle technique performed by third-year dental students. Material and Method: Descriptive observational study. 220 radiographs were evaluated, performed by 55 third-year dental students. Radiographic quality was evaluated by two researchers, using a guideline created with four parameters: film position, horizontal angulation, vertical angulation and centered X-ray (conecut). The quality was compared according to the radiographic sector, anterior and posterior. Descriptive statistics and chi-2 test were applied to establish differences between radiographic sector and radiographic quality, setting a value of statistical significance of p 0.005. Conclusions: The periapical radiographs taken by third-year dental students using the bisecting angle technique is mostly of unacceptable quality, with no significant differences between sectors.

Medición radiológica del extremo proximal del fémur / Radiological measurement of the femoral proximal end

El objetivo de este trabajo es determinar las mediciones radiológicas del extremo proximal del fémur en pacientes adultos cuyos casos fueron presentados en las discusiones clínico-radiológicas del servicio de Traumatología y Ortopedia del Hospital Central de San Cristóbal entre 2015 y 2021. Se realizó un estudio prospectivo, descriptivo, transversal, que incluyó los estudios radiológicos de cadera sana en proyección anteroposterior de pelvis centrada en pubis con rotación interna de 15 %, de 126 pacientes entre 20 y 95 años. Se midieron: ángulo cervicodiafisario, lateralización femoral, longitud y ancho del cuello femoral y diámetro de la circunferencia cefálica, mediante el sotfware MicroDicom DICOM 4.0.0. La media de ángulo cervicodiafisario fue 130,8 ± 4,5 grados, en 57 individuos (45,2 %) estuvo entre 127,4 y 133,3 grados (p = 0,001); la circunferencia cefálica media fue 42,0 ± 2,4 mm, en 60 personas (47,6 %) estuvo entre 40,2 y 45,7 mm (p = 0,001); la longitud cervical media fue 78,6 ± 16,4 mm, en 54 individuos (42,9 %) estuvo entre 69,4 y 92 mm (p = 0,001); el ancho cervical medio fue 75,9 ± 12,1 mm, en 64 casos, (50,8 %) estuvo entre 62,9 y 78,7 mm (p = 0,001). En 60 individuos (47,6 %) la lateralización del fémur estuvo entre 92,6 - 117,7 mm. Las medidas son independientes del sexo; a medida que aumenta la edad, el ángulo cervicodiafisario es menor (p= 0,021). Se realizaron tablas percentiladas de las medidas radiológicas del extremo proximal del fémur, según edad y sexo, que pueden servir de referencia en pacientes futuros(AU)

The objective of this work is to determine the radiological measurements of the proximal end of the femur in adult patients whose cases were presented in the clinical-radiological discussions of the Traumatology and Orthopedics service of the Central Hospital of San Cristóbal between 2015 and 2021. A prospective study was carried out, descriptive, crosssectional, which included radiological studies of a healthy hip in anteroposterior projection of the pelvis centered on the pubis with internal rotation of 15%, of 126 patients between 20 and 95 years of age. The following were measured: cervicodiaphyseal angle, femoral lateralization, length and width of the femoral neck, and diameter of the head circumference, using the MicroDicom DICOM 4.0.0 software. The mean neck-diaphyseal angle was 130.8 ± 4.5 degrees, in 57 individuals (45.2%) it was between 127.4 and 133.3 degrees (p = 0.001); the mean head circumference was 42.0 ± 2.4 mm, in 60 people (47.6%) it was between 40.2 and 45.7 mm (p = 0.001); the mean cervical length was 78.6 ± 16.4 mm, in 54 individuals (42.9 %) it was between 69.4 and 92 mm (p = 0.001); the mean cervical width was 75.9 ± 12.1 mm, in 64 cases (50.8%) it was between 62.9 and 78.7 mm (p= 0.001). In 60 individuals (47.6%), the lateralization of the femur was between 92.6 - 117.7 mm. The measurements are independent of sex; as age increases, the cervical shaft angle is less (p= 0.021). Percentage tables of the radiological measurements of the proximal end of the femur were made, according to age and sex, which can serve as a reference in future patients(AU)

Efectividad del B-learning como Metodología de Enseñanza-Aprendizaje de Radiología Oral en 6 ° año de la Carrera de Odontología de la Universidad de los Andes, Chile / Effectiveness of B-learning as a Teaching-Learning Methodology for Oral Radiology in Undergraduate Students in Dentistry at the Universidad de los Andes

RESUMEN: Se realizó una innovación metodológica en el proceso de enseñanza-aprendizaje de radiología oral en la carrera de Odontología de la Universidad de los Andes. Se implementó un curso Radiología Oral con la modalidad b-learning en el 6° año 2018, basado en la plataforma Moodle. Esta intervención no constituía un cambio curricular, sino que solo metodológico. Se evaluó si el b-learning era una metodología efectiva para el proceso de enseñanza-aprendizaje en el curso de radiología oral de 6° año de Odontología de la Universidad de los Andes, Chile. Se compararon las calificaciones obtenidas en una prueba sumativa final por el grupo de estudio (b-learning) respecto de las obtenidas por el grupo control (metodología tradicional aplicada los 5 años anteriores). Se valoró la percepción de los estudiantes, respecto de la metodología b-learning, para lo cual se aplicó una encuesta que consideraba 4 variables: comprensión, tiempo ocupado, motivación y rol moderador del profesor. Los alumnos con modalidad b-learning obtuvieron notas significativamente más altas que los alumnos que siguieron el mismo curso con modalidad presencial. Los estudiantes que trabajaron con modalidad b-learning se declararon satisfechos con el enfoque b-learning para aprender radiología oral en 6 ° año de Odontología de la Universidad de los Andes. El 95,5 % señaló que esta metodología motiva su aprendizaje y el 100 % la recomendaría a un compañero. El 97,7 % de los alumnos indicó que la metodología b-learning les permitía contar con la ayuda oportuna del profesor y el 95,5 % que el actuar del profesor facilitó su aprendizaje. El b-learning es una metodología efectiva para el proceso de enseñanza-aprendizaje en el curso de radiología oral. Los alumnos con modalidad b-learning obtuvieron notas significativamente más altas que los alumnos que siguieron el mismo curso con modalidad presencial. Los estudiantes se declaran satisfechos con el enfoque b-learning.

ABSTRACT: A methodological innovation is carried out in the teaching-learning process of oral radiology in the Dentistry career of the Universidad de los Andes, an Oral Radiology course was implemented with the b-learning modality in the 6th year 2018, based on on the Moodle platform. This intervention does not constitute a curricular change, but only a methodological one. It was evaluated whether b-learning is an effective methodology for the teaching-learning process in the oral radiology course of the 6th year of Dentistry at the Universidad de los Andes. The scores obtained in a final summative test by the study group (b-learning) were compared with those obtained by the control group (traditional methodology applied the previous 5 years). The perception of the students regarding the b-learning methodology was assessed, for which a survey was applied that considers 4 variables: comprehension, time occupied, motivation and the moderating role of the teacher. The students with the b-learning modality obtained significantly higher grades than the students who followed the same course with the face-to-face modality. The students who worked with the b-learning modality declared themselves satisfied with the b-learning approach to learn oral radiology in the 6th year of Dentistry at the Universidad de los Andes. 95.5% indicated that this methodology motivates their learning and 100% would recommend it to a colleague. 97.7% of the students indicated that the b-learning methodology allows them to have timely help from the teacher and 95.5% that the teacher's actions facilitated their learning. B-learning is an effective methodology for the teaching-learning process in the oral radiology course. The students with the b-learning modality obtained significantly higher grades than the students who followed the same course with the face-to-face modality. The students declare themselves satisfied with the b-learning approach.

Guidelines for Diagnosis and Treatment of Pancreatic Cystic Neoplasms Based on Radiology / 中国医学科学院学报

As the detection rate of pancreatic cystic neoplasms (PCN) increases,recommendations or guidelines for the diagnosis and treatment of PCN have been released from professional organizations.From the perspective of radiology,we compared seven guidelines in terms of general introduction,preoperative monitoring methods and strategies,stratification of risk factors,surgical indications,and postoperative follow-ups,aiming to provide references for the evaluation of images and the formulation of individualized approach for the treatment of PCN.

CO-RADS: aplicación móvil para la estandarización del informe radiológico en el contexto de la COVID 19 / CO-RADS: Mobile Application for Standardization of the Radiological Report in the Context of COVID 19

El nuevo coronavirus denominado SARS-COV2 causa diversas manifestaciones clínicas englobadas bajo el término COVID-19. El sistema de informe y datos conocidos por sus siglas en inglés como RADS, determinadas a partir del consenso de expertos producido por un grupo de trabajo multidisciplinario con el objetivo de mejorar la comunicación de los resultados, establece un enfoque estándar para la notificación de manifestaciones imagenológicas. El presente trabajo presenta el prototipo de aplicación CO-RADS que propone una herramienta digital sobre la base de una revisión actualizada del papel y la idoneidad de los estudios de imagenología para el diagnóstico y seguimiento de pacientes con sospecha o infección conocida de COVID-19, proporcionando terminología estandarizada de imágenes para lograr comunicar los resultados al médico de asistencia de manera clara y consistente. CO-RADS es una aplicación gratuita que se encuentra disponible en: htttps://www.aplikis.cu/es/application/cu.sld.hlucia.corads(AU)

The new coronavirus called SARS-COV2 causes various clinical manifestations encompassed under the term COVID-19. The data and reporting system known by its acronym in English as RADS, establishes a standard approach for the notification of imaging manifestations with the aim of improving the communication of results; was determined from the consensus of experts produced by a multidisciplinary working group. This paper presents the CO-RADS application prototype that proposes a digital tool based on an updated review of the role and suitability of imaging studies for the diagnosis and follow-up of patients with suspected or known COVID-19 infection, providing standardized imaging terminology to achieve clear and consistent communication of results to the attending physician. CO-RADS is a free application that is available at: htttps://www.aplikis.cu/es/application/cu.sld.hlucia.corads(AU)

Rastreio radiológico para tuberculose em uma penitenciária do sul do Brasil / Radiological screening for tuberculosis in a prison in the south of Brazil

Introdução: Conhecer o perfil da população privada de liberdade da Penitenciária Modulada de Osório (PMO), do ponto de vista radiológico e estimar a prevalência da tuberculose ativa no presídio.Métodos: Foi realizada análise retrospectiva de 677 radiografias de tórax obtidas para rastreio de tuberculose e de dados da ficha de atendimento do setor de Radiologia no período de julho a outubro de 2019.Resultados: Foram detectadas 150 radiografias alteradas, o que representa 22% dos 677 exames. Dos 150 exames alterados, 109 (16% do total e 72% dos alterados) apresentavam lesões com características de doença granulomatosa. Dos 677 pacientes, 11,5% referiram tratamento atual ou prévio para tuberculose e estes representam 38% dos casos com radiografias alteradas. Foram detectados 50 pacientes sem história prévia de tuberculose com lesões de aspecto muito provavelmente devido a tuberculose com características de doença ativa (7,3% do total), os quais foram encaminhados para investigação como casos novos. Em relação ao questionário aplicado, não foi observada diferença significativa entre os pacientes que referiam ou negavam tosse entre os com exames normais e alterados.Conclusões: Os indivíduos privados de liberdade apresentaram alta prevalência de alterações radiológicas com aspecto sugestivo de doença granulomatosa. Estes achados permitem inferir que na Penitenciária Modulada de Osório há elevada prevalência de tuberculose, provavelmente em níveis semelhantes a outras casas prisionais do Brasil.

Introduction: To determine the radiologic profile of 'the prisoners at Osório Modular Prison and estimate the prevalence of active tuberculosis in the institution.Methods: We retrospectively analyzed 677 chest radiographs obtained for tuberculosis screening and data from the medical records of prisoners seen at the Radiology Department from July to October 2019.Results: Of 677 radiographs, 150 (22%) showed abnormalities. Of these, 109 (16% of total or 72% of abnormal radiographs) showed lesions characteristic of granulomatous disease. Of all 677 patients, 11.5% reported current or previous treatment of tuberculosis, accounting for 38% of all abnormal radiographs. Fifty patients with no previous history of tuberculosis had lesions that were most likely due to active tuberculosis (7.3% of total), and were referred for further investigation as new cases. The responses to the questionnaire revealed no significant difference between patients who reported or denied coughing when comparing those with normal vs abnormal radiographs.Conclusions: Individuals deprived of liberty had a high prevalence of radiologic abnormalities suggestive of granulomatous disease. These findings allow us to infer that there is a high prevalence of tuberculosis at Osório Modular Prison, probably at levels comparable to those of other prison facilities in Brazil.

Inteligencia artificial: una herramienta en la imagenología para los pacientes positivos a la COVID-19 / Artificial intelligence: an imaging tool for COVID-19 positive patients

RESUMEN Introducción: la enfermedad por SARS-Cov-2 refuerza la importancia del uso de las nuevas tecnologías de la información y las comunicaciones en función del desarrollo e implementación de sistemas de inteligencia artificial que favorecen el diagnóstico. Objetivo: describir la posibilidad del uso de la inteligencia artificial como una herramienta en la imagenología para los pacientes positivos a la COVID-19. Métodos: se realizó una revisión de fuentes bibliográficas en Infomed, SciELO, PubMed y Google Académico, comprendidas en los años 2015 al 2020 con el uso de palabras claves: coronavirus, COVID-19, neumonía, radiografía e inteligencia artificial. Se seleccionaron 28 documentos por su pertinencia en el estudio. Desarrollo: la creación de sistemas de inteligencia artificial que ayuden al diagnóstico médico requiere un enfoque interprofesional de la ciencia y constituye una de las líneas de trabajo en Cuba durante la pandemia. Una condición indispensable para la introducción de la inteligencia artificial en el diagnóstico radiológico es la capacitación que deben recibir los médicos para interactuar con ella, a través de un proceso formativo que incluya una evaluación y explicación de la calidad de los datos asociada tanto al aprendizaje como a las nuevas predicciones. Conclusiones: la utilización de inteligencia artificial mejorará el rendimiento del radiólogo para distinguir la COVID-19; la integración de estas tecnologías en el flujo de trabajo clínico de rutina puede ayudar a los radiólogos a diagnosticar con precisión.

ABSTRACT Introduction: SARS-Cov-2 disease reinforces the importance of the use of new information and communication technologies based on the development and implementation of artificial intelligence systems that favor diagnosis. Objective: to describe the possibility of using artificial intelligence as a tool in imaging for COVID-19 positive patients. Methods: a review of bibliographic sources was carried out in Infomed, SciELO, PubMed and Google Scholar, from 2015 to 2020 with the use of keywords: coronavirus, COVID-19, pneumonia, radiography and artificial intelligence. 28 documents were selected for their relevance in the study. Development: the creation of artificial intelligence systems that help medical diagnosis requires an interprofessional approach to science and constitutes one of the lines of work in Cuba during the pandemic. An essential condition for the introduction of artificial intelligence in radiological diagnosis is the training that doctors must receive to interact with it, through a training process that includes an evaluation and explanation of the quality of the data associated with both learning and to new predictions. Conclusions: the use of artificial intelligence will improve the radiologist's performance to distinguish COVID-19; integrating these technologies into routine clinical workflow can help radiologists diagnose accurately.

Giant pulmonary artery aneurysms / Aneurismas gigantes de arteria pulmonar

The accompanying images demonstrate giant pulmonary artery aneurysms in a patient with idiopathic pulmonary arterial hypertension (Image 1). In addition to the main pulmonary artery, both the left and right pulmonary arteries are aneurysmal and are compressing the lung parenchyma (Image 2).

Las imágenes adjuntas muestran aneurismas gigantes de la arteria pulmonar en un paciente con hipertensión arterial pulmonar idiopática (Imagen 1). Además de la arteria pulmonar principal, tanto la arteria pulmonar izquierda como la derecha son aneurismáticas y están comprimiendo el parénquima pulmonar (Imagen 2).

Analysis of Intraoperative Exposure to X-rays and Surgical Time in Different Techniques for Fixation of Transtrochanteric Fractures of the Femur / Análise da exposição intraoperatória ao raio X e do tempo cirúrgico em diferentes técnicas de fixação das fraturas transtrocanterianas do fêmur*

Abstract Objective The present study aimed to evaluate and compare the total surgical procedure time and intraoperative X-ray exposure during different techniques for fixation of transtrochanteric fractures of the femur in elderly patients, using extramedullary and intramedullary methods based on cephalic traction screws. Methods The Orthopedics and Traumatology Service from our hospital evaluated 107 patients with transtrochanteric fractures, including 34 males and 73 females, with age ranging from 61 to 101 years old. Fracture fixation was performed with a dynamic hip system (DHS) in 21 patients, a standard proximal femoral nail (PFN) in 55 subjects, and a standard gamma nail in 31 patients. All procedures were performed by the same surgeon and his team of nursing assistants, along with the same radiology technician using the same image intensifier. Total surgery time (in minutes) and X-ray emission (in centigrays [cGy]) were evaluated. Results Transtrochanteric fracture fixation with PFN provides a significantly shorter surgical time (p = 0.013) in comparison to the 2 other techniques. Intraoperative exposure to X-rays was significantly lower when using DHS (p = 0.015) as a fixation method when compared with gamma nail and PFN. Conclusion Although PFN resulted in the shortest surgical time, DHS was associated with the lowest X-ray exposure levels within the studied sample.

Resumo Objetivo Avaliar e comparar o tempo total do procedimento cirúrgico e a exposição ao raio X no intraoperatório em diferentes técnicas de fixação das fraturas transtrocanterianas do fêmur em pacientes idosos, utilizando técnicas extramedulares e intramedulares baseadas em parafuso de tração cefálico. Métodos Foram avaliados no serviço de ortopedia e traumatologia do nosso hospital 107 pacientes com fraturas transtrocanterianas, sendo 34 do sexo masculino e 73 do sexo feminino, com idade mínima de 61 anos e máxima de 101 anos. As fraturas fixadas, utilizando a técnica com dynamic hip system (DHS, na sigla em inglês) somaram 21 pacientes; em 55 pacientes, foi utilizado o proximal femur nail (PFN, na sigla em inglês) standard; e em 31 idosos, foi optado pelo uso do gama nail standard. Todos os procedimentos foram realizados pelo mesmo cirurgião acompanhado de sua equipe de auxiliares de enfermagem, assim como pelo mesmo técnico de radiologia manuseando o mesmo intensificador de imagens. Foram avaliados o tempo total da cirurgia (em minutos) e a emissão de raios X medida em centigrays. Resultados A fixação das fraturas transtrocanterianas com PFN proporciona um menor tempo cirúrgico com uma diferença estatística significativa (p =0,013), quando comparada com as demais técnicas utilizadas entre os grupos envolvidos. Foi observada, também, uma menor exposição intraoperatória aos raios X (p =0,015), a qual foi estatisticamente relevante quando utilizado o DHS como método de fixação comparado com o gama nail e o PFN. Conclusão Apesar do PFN ter o menor tempo de cirurgia, a técnica do DHS se mostrou com menores níveis de exposição dentro da amostra estudada.

Adult-onset non-5q proximal spinal muscular atrophy: a comprehensive review / Atrofia muscular espinhal não-5q proximal de início no adulto: uma revisão abrangente

Abstract Background: Adult-onset spinal muscular atrophy (SMA) represents an expanding group of inherited neurodegenerative disorders in clinical practice. Objective: This review aims to synthesize the main clinical, genetic, radiological, biochemical, and neurophysiological aspects related to the classical and recently described forms of proximal SMA. Methods: The authors performed a non-systematic critical review summarizing adult-onset proximal SMA presentations. Results: Previously limited to cases of SMN1-related SMA type 4 (adult form), this group has now more than 15 different clinical conditions that have in common the symmetrical and progressive compromise of lower motor neurons starting in adulthood or elderly stage. New clinical and genetic subtypes of adult-onset proximal SMA have been recognized and are currently target of wide neuroradiological, pathological, and genetic studies. Conclusions: This new complex group of rare disorders typically present with lower motor neuron disease in association with other neurological or systemic signs of impairment, which are relatively specific and typical for each genetic subtype.

RESUMO Antecedentes: Atrofia muscular espinhal (AME) de início no adulto representa um grupo de doenças neurodegenerativas hereditárias em expansão na prática clínica. Objetivo: Este artigo de revisão sintetiza os principais aspectos clínicos, genéticos, radiológicos, bioquímicos e neurofisiológicos relacionados às formas clássicas e recentemente descritas de AME proximal do adulto. Métodos: Os autores realizaram uma revisão crítica não sistemática descrevendo as principais apresentações de AME proximal de início no adulto. Resultados: Previamente restrito às apresentações de AME tipo 4 associada ao gene SMN1, este grupo atualmente envolve mais de 15 diferentes condições clínicas que compartilham entre si a presença de comprometimento progressivo e simétrico do neurônio motor inferior se iniciando no adulto ou no idoso. Novos subtipos clínicos e genéticos de AME proximal de início no adulto foram reconhecidas e são alvos atuais de estudos direcionados a aspectos neurorradiológicos, patológicos e genéticos. Conclusões: Este novo grupo complexo de doenças raras tipicamente se apresenta com doença do neurônio motor inferior em associação com outros sinais de comprometimento neurológico ou sistêmico, os quais apresentam padrões relativamente específicos para cada subtipo genético.