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1.
West China Journal of Stomatology ; (6): 218-224, 2023.
Article in English | WPRIM | ID: wpr-981115

ABSTRACT

OBJECTIVES@#This study aims to predict the risk of deep caries exposure in radiographic images based on the convolutional neural network model, compare the prediction results of the network model with those of senior dentists, evaluate the performance of the model for teaching and training stomatological students and young dentists, and assist dentists to clarify treatment plans and conduct good doctor-patient communication before surgery.@*METHODS@#A total of 206 cases of pulpitis caused by deep caries were selected from the Department of Stomatological Hospital of Tianjin Medical University from 2019 to 2022. According to the inclusion and exclusion criteria, 104 cases of pulpitis were exposed during the decaying preparation period and 102 cases of pulpitis were not exposed. The 206 radiographic images collected were randomly divided into three groups according to the proportion: 126 radiographic images in the training set, 40 radiographic images in the validation set, and 40 radiographic images in the test set. Three convolutional neural networks, visual geometry group network (VGG), residual network (ResNet), and dense convolutional network (DenseNet) were selected to analyze the rules of the radiographic images in the training set. The radiographic images of the validation set were used to adjust the super parameters of the network. Finally, 40 radiographic images of the test set were used to evaluate the performance of the three network models. A senior dentist specializing in dental pulp was selected to predict whether the deep caries of 40 radiographic images in the test set were exposed. The gold standard is whether the pulp is exposed after decaying the prepared hole during the clinical operation. The prediction effect of the three network models (VGG, ResNet, and DenseNet) and the senior dentist on the pulp exposure of 40 radiographic images in the test set were compared using receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score to select the best network model.@*RESULTS@#The best network model was DenseNet model, with AUC of 0.97. The AUC values of the ResNet model, VGG model, and the senior dentist were 0.89, 0.78, and 0.87, respectively. Accuracy was not statistically different between the senior dentist (0.850) and the DenseNet model (0.850)(P>0.05). Kappa consistency test showed moderate reliability (Kappa=0.6>0.4, P<0.05).@*CONCLUSIONS@#Among the three convolutional neural network models, the DenseNet model has the best predictive effect on whether deep caries are exposed in imaging. The predictive effect of this model is equivalent to the level of senior dentists specializing in dental pulp.


Subject(s)
Humans , Deep Learning , Neural Networks, Computer , Pulpitis/diagnostic imaging , Reproducibility of Results , ROC Curve , Random Allocation
2.
ABCS health sci ; 47: e022223, 06 abr. 2022. ilus, tab
Article in English | LILACS | ID: biblio-1398278

ABSTRACT

INTRODUCTION: Rheumatoid arthritis (RA) is classified as an autoimmune, chronic disease affecting diarthrodial joints and periarticular structures. OBJECTIVE: To evaluate whether low-intensity laser treatment (LLLT) and/or exercise reduce the deleterious effects of tissue in a rheumatoid arthritis model. METHODS: 128 rats were divided into two inflammatory periods: acute (7 days) and chronic (28 days) and subdivided into control, injury and treatment. The protocol with Freund's Complete Adjuvant was used in two inoculations, one intradermal and one intraarticular in the tibiofemoral joint, the control animals received saline solution. For treatment, LLLT 660 nm, 5 J/cm² was used in the sensitized joint and climbing exercise in stairways with an overload of 100 grams. After the experimental period, the animals were euthanized and the joints were prepared for morphometric analysis of the total thickness, superficial, deep, and cellular density of the articular cartilage. Generalized Linear Models with Sidak post-test were chosen. RESULTS: The control group was found to be different from the lesion group with greater joint cartilage thickness, andthe animals treated with exercise alone increased the joint cartilage compared to thecontrol group. CONCLUSION: The animals treated with laser association and exercise showed improvement in the morphometric aspects of the articular cartilage.


Subject(s)
Animals , Rats , Arthritis, Rheumatoid/radiotherapy , Rats/anatomy & histology , Exercise , Cartilage, Articular/anatomy & histology , Freund's Adjuvant , Low-Level Light Therapy , Random Allocation , Intervention Studies , Models, Animal
3.
Chinese Acupuncture & Moxibustion ; (12): 85-90, 2022.
Article in Chinese | WPRIM | ID: wpr-927339

ABSTRACT

Heat-sensitive moxibustion is the appropriate technique of the external treatment in traditional Chinese medicine and it is widely used in community because of its "easy learning, simple operation and clear curative effect". Pragmatic randomized controlled trial is a main intervention design in the real world study, which provides a high-level evidence for the effectiveness assessment of heat-sensitive moxibustion in community management. Focusing on the key links of randomization, e.g. block randomization, stratified randomization, cluster randomization, sample size allocation, allocation concealment and blinding, the paper elaborates the advantages, disadvantages and technical details of two-stage randomization with consideration of patient preference in pragmatic randomized controlled trials of heat-sensitive moxibustion in community. It facilitates improving the quality of evidence, reproducibility and methodological homogeneity among different trials.


Subject(s)
Humans , Hot Temperature , Moxibustion , Patient Preference , Random Allocation , Reproducibility of Results
4.
Rev. bras. oftalmol ; 81: e0054, 2022. tab
Article in English | LILACS | ID: biblio-1387978

ABSTRACT

ABSTRACT Purpose Evaluate blue-violet light filter and additional power of +0.40 D in the near zone ophthalmic lenses, on convergence, accommodative functions, and symptoms of digital asthenopia (DA). Methods Randomized study in cross-over design conducted on 49 volunteers (age, 29 ± 5.5 years; male: female, 18:31). Each subject wore test (+0.40 D in the near zone) and control lenses (regular single vision) for 4 weeks in randomized order. Both lenses had a selective blue-violet light filter. A baseline measurement was taken with the subjects' current updated glasses. Accommodation amplitude (AA) and near point of convergence (NPC) were measured binocularly with the RAF ruler. DA was evaluated by a questionnaire. Results No significant difference (p=.52) was found for AA comparing baseline (11.50±1.88 D), test (11.61± 1.62 D), and control SV lenses (11.88±1.50 D). No significant difference was found for NPC (p=.94), between baseline (6.50 ± 2.89cm), test (6.71± 3.49) and control SV lenses (6.82± 3.50 cm). No significant difference was found comparing test and control SV lenses in symptoms of DA (p=0.20). Conclusions The +0.40 D lenses have no negative impact on convergence or loss of accommodation power. The +0.40 D and control SV lenses had a similar impact on attenuating symptoms of DA.


RESUMO Objetivo Avaliar os efeitos do uso de lentes oftálmicas com filtro seletivo de luz azul-violeta, sem e com poder adicional de + 0,4D na zona de perto nas funções de acomodação e convergência e para sintomas de astenopia digital (AD). Métodos Ensaio clínico controlado, randomizado e mascarado, com 49 voluntários (idade, 29 ± 5,5 anos; masculino: feminino, 18: 31). Cada participante usou lentes de teste (+0,40 D na zona de perto) e controle (visão simples), por 4 semanas de forma randomizada. Ambas as lentes tinham filtro seletivo de luz azul-violeta. A medição inicial (baseline) foi feita com os óculos atualizados de cada participante. A amplitude de acomodação (AA) e o ponto de convergência próximo (PPC) foram medidos binocularmente com a régua RAF. A AD foi avaliada por um questionário. Resultados Não houve diferença estatisticamente significante (p=0,52) para as medidas de AA comparando as lentes baseline (11,50±1,88 D), teste (11,61±1,62 D) e controle VS (11,88±1,50 D). Nenhuma diferença significativa foi encontrada para a medida do PPC (p=0,94), entre as lentes baseline (6,50 ± 2,89cm), teste (6,71±3,49) e controle VS (6,82±3,50 cm). Nenhuma diferença significativa foi encontrada comparando lentes teste de VS e controle nos sintomas de AD (p=0,20). Conclusões As lentes com +0,40 D não têm impacto negativo na convergência ou na perda de acomodação. As lentes +0,40 D e controle VS, tiveram impacto semelhante na redução dos sintomas de AD.


Subject(s)
Humans , Male , Female , Adult , Lighting/adverse effects , Computers , Asthenopia/prevention & control , Eyeglasses , Filtration/instrumentation , Light/adverse effects , User-Computer Interface , Dry Eye Syndromes/etiology , Dry Eye Syndromes/prevention & control , Random Allocation , Asthenopia/etiology , Surveys and Questionnaires , Computers, Handheld , Smartphone , Accommodation, Ocular/physiology
5.
Acta Paul. Enferm. (Online) ; 35: eAPE02116, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1393706

ABSTRACT

Resumo Objetivo Comparar o tempo de execução do banho no leito pelo método tradicional e a seco e seus efeitos sobre as alterações oxi-hemodinâmicas em pacientes críticos. Métodos Ensaio clínico randomizado crossover, aberto, com 50 pacientes submetidos aos dois tipos de banho no leito: tradicional e a seco. Avaliou-se o tempo de execução dos banhos e as variáveis oxi-hemodinâmicas (temperatura timpânica e axilar, saturação de oxigênio arterial, frequência respiratória, frequência cardíaca e pressão arterial média), obtidas no início dos banhos, aos dez minutos, no início e no fim da lateralização dos pacientes, ao final do procedimento e 15 minutos depois. Para análise utilizou-se Teste T de Student pareado e modelo de equações de estimação generalizadas. Resultados O banho no leito a seco foi executado em menor tempo que o tradicional (18,59 versus 26,45 minutos; p<0,001). No banho tradicional, ao longo do tempo, houve redução da temperatura axilar e elevação da frequência respiratória (p<0,001). No banho a seco, apenas a temperatura axilar sofreu alteração, tornando-se menor que o valor inicial (p<0,001). Conclusão O banho a seco foi superior ao tradicional em decorrência do menor tempo de execução e menor instabilidade oxi-hemodinâmica dos pacientes entre os períodos observados. A monitorização dos pacientes é fundamental para identificar tais alterações.


Resumen Objetivo Comparar el tiempo de ejecución del baño en cama mediante el método tradicional y a seco y sus efectos sobre las alteraciones oxihemodinámicas en pacientes críticos. Métodos Ensayo clínico aleatorizado crossover, abierto, con 50 pacientes sometidos a dos tipos de baño en cama: tradicional y a seco. Se evaluó el tiempo de ejecución de los baños y las variables oxihemodinámicas (temperatura timpánica y axilar, saturación del oxígeno arterial, frecuencia respiratoria, frecuencia cardíaca y presión arterial promedio), obtenidas al comienzo de los baños, a los diez minutos, al comienzo y al final de la lateralización de los pacientes, al final del procedimiento y 15 minutos después. Para el análisis se utilizó el Test-T de Student pareado y el modelo de ecuaciones de estimación generalizadas. Resultados El baño en cama a seco fue ejecutado en menor tiempo que el tradicional (18,59 versus 26,45 minutos; p<0,001). En el baño tradicional, a lo largo del tiempo, hubo reducción de la temperatura axilar y elevación de la frecuencia respiratoria (p<0,001). En el baño a seco, solo la temperatura axilar estuvo alterada, fue menor que el valor inicial (p<0,001). Conclusión El baño a seco fue superior al tradicional como consecuencia del menor tiempo de ejecución y menor inestabilidad oxihemodinámica de los pacientes entre los períodos observados. El monitoreo de los pacientes es fundamental para identificar tales alteraciones.


Abstract Objective To compare the bed bath execution time using the traditional and dry method and its effects on the oxy-hemodynamic changes in critically ill patients. Methods This is a crossover, open, randomized clinical trial, with 50 patients submitted to two types of bed bath: traditional and dry. The duration of the baths and the oxy-hemodynamic variables (tympanic and axillary temperature, arterial oxygen saturation, respiratory rate, heart rate and mean arterial pressure), obtained at the beginning of the baths, at ten minutes, at the beginning and at the end of patient lateralization, at the end of the procedure and 15 minutes later. Paired Student's t-test and generalized estimating equations model were used for analysis. Results Dry bed bath was performed in less time than the traditional bath (18.59 versus 26.45 minutes; p<0.001). In traditional bath, over time, there was a reduction in axillary temperature and an increase in respiratory rate (p<0.001). In the dry bath, only the axillary temperature changed, becoming lower than the initial value (p<0.001). Conclusion Dry bath was superior to the traditional one, due to the shorter time of execution and lesser oxy-hemodynamic instability of patients between the periods observed. Monitoring patients is essential to identify such changes.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Aged , Baths , Beds , Critical Care , Hemodynamics , Intensive Care Units , Nursing Care , Random Allocation , Cross-Over Studies
6.
Rev. bras. oftalmol ; 81: e0035, 2022. tab
Article in English | LILACS | ID: biblio-1376791

ABSTRACT

ABSTRACT Objective: To evaluate the efficacy of mitomycin C in anatomical and functional success after modified transcanalicular diode laser dacryocystorhinostomy. Methods: A prospective, double-blinded, randomized placebo-controlled study compared the effect of topical mitomycin C on modified transcanalicular diode laser dacryocystorhinostomy. Group 1 had modified transcanalicular diode laser dacryocystorhinostomy with topical saline, while Group 2 had modified transcanalicular diode laser dacryocystorhinostomy with topical mitomycin C. Success was defined as anatomical patency and relief of symptoms at the end of 6 months. Results: Six months after surgery, Group 1 (30 patients) showed anatomical and functional success rates of 86.7% and 83.3%, respectively. Group 2 (32 patients) showed anatomical and functional success rates of 87.5% and 84.3%, respectively. There was no statistically significant difference between the groups 1 and 2 (p = 1.000). Conclusion: The use of mitomycin C did not improve the anatomical and functional success rates of modified transcanalicular diode laser dacryocystorhinostomy compared to placebo.


RESUMO Objetivo: Avaliar a eficácia da mitomicina C no sucesso anatômico e funcional após dacriocistorrinostomia transcanalicular com laser de diodo. Métodos: Estudo prospectivo, duplo-cego, randomizado e controlado por placebo. Comparou o efeito da mitomicina C tópica na dacriocistorrinostomia transcanalicular com laser de diodo. No Grupo 1, foi utilizada apenas solução salina tópica, enquanto no Grupo 2 foi utilizada mitomicina C tópica. O sucesso foi definido como permeabilidade da via lacrimal e alívio dos sintomas ao final de 6 meses. Resultados: Seis meses após a cirurgia, o Grupo 1 (30 pacientes) apresentou taxas de sucesso anatômico e funcional de 86,7% e 83,3%, respectivamente. O Grupo 2 (32 pacientes) apresentou taxas de sucesso anatômico e funcional de 87,5% e 84,3%, respectivamente. Não houve diferença estatística significante entre os Grupos 1 e 2 (p=1,000). Conclusão: O uso de mitomicina C não melhora as taxas de sucesso anatômico e funcional do dacriocistorrinostomia transcanalicular com laser de diodo em comparação ao placebo.


Subject(s)
Humans , Male , Female , Middle Aged , Dacryocystorhinostomy/methods , Mitomycin/administration & dosage , Mitomycin/therapeutic use , Mitomycin/pharmacology , Lasers, Semiconductor/therapeutic use , Nasolacrimal Duct/drug effects , Placebos , Random Allocation , Double-Blind Method , Prospective Studies , Follow-Up Studies , Treatment Outcome , Chemotherapy, Adjuvant , Dacryocystitis/surgery , Laser Therapy/methods , Lacrimal Duct Obstruction/therapy , Nasolacrimal Duct/surgery
7.
Acta Paul. Enferm. (Online) ; 35: eAPE0010345, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1374001

ABSTRACT

Resumo Objetivo Avaliar parâmetros hematológicos de crianças desnutridas após intervenção nutricional com farinha da castanha de caju. Métodos Ensaio clínico randomizado, controlado, cego. O estudo foi realizado no período de abril a dezembro de 2017, em duas Unidades Básicas de Saúde. A amostra foi composta de crianças menores de 5 anos que preencheram os critérios de inclusão, sendo 15 no Grupo Intervenção (farinha da castanha de caju) e 15 crianças no Grupo Controle (farinha de carboximetilcelulose), alocadas nos grupos de forma randômica aleatória simples. Foram analisados os parâmetros de eritrócitos, hemoglobina e hematócrito (série vermelha) e de leucócitos, neutrófilos, segmentados, eosinófilos, monócitos e linfócitos (série branca). A coleta de sangue foi realizada em dois momentos: o primeiro antes da implementação da intervenção e o segundo após 32 semanas de utilização da farinha da castanha de caju. Para avaliação da normalidade e homogeneidade da amostra, utilizaram-se os testes de Shapiro-Wilk e de variância de Bartlett, respectivamente. Utilizou-se o teste T pareado dentro de cada grupo e, para avaliar possíveis associações entre os Grupos Intervenção e Controle e o nível de leucócitos (abaixo, normal e acima), utilizaram-se o teste exato de Fisher e/ou o teste Fisher-Freeman-Halton. Resultados Houve incremento na média das células individuais da série vermelha do hemograma, sobretudo nos padrões de hemoglobina de crianças desnutridas do Grupo Intervenção (p<0,05). A investigação também apontou diferença intragrupo no parâmetro da hemoglobina, tanto no Grupo Controle (p=0,007) como no Intervenção (p<0,001), bem como no parâmetro hematócrito para ambos os grupos (p=0,001). Especificamente na série branca, após a intervenção, evidenciou-se diminuição significativa nos leucócitos (p=0,04) e linfócitos (p<0,01) Conclusão Após intervenção, a utilização da farinha da castanha de caju melhorou os parâmetros hematológicos das crianças desnutridas. Registro Brasileiro de Ensaios Clínicos (REBEC): U1111.1213.9219


Resumen Objetivo Evaluar parámetros hematológicos de niños desnutridos después de la intervención nutricional con harina da castaña de cajú. Métodos Ensayo clínico aleatorizado, controlado, ciego. El estudio se realizó en el período de abril a diciembre de 2017, en dos Unidades Básicas de Salud. La muestra se compuso por niños menores de 5 años que cumplieron con los criterios de inclusión, 15 en el Grupo Intervención (harina de castaña de cajú) y 15 niños en el Grupo Control (harina de carboximetilcelulosa), repartidas en los grupos de forma muestreo aleatorio simple. Se analizaron los parámetros de eritrocitos, hemoglobina e hematocrito (serie roja) y de leucocitos, neutrófilos, segmentados, eosinófilos, monocitos e linfocitos (serie blanca). La muestra de sangre se realizó en dos momentos: el primero antes de la implementación de la intervención y el segundo después de 32 semanas de utilización de la harina da castaña de cajú. Para la evaluación de la normalidad y la homogeneidad de la amuestra, se utilizaron los tests de Shapiro-Wilk y de varianza de Bartlett, respectivamente. Se utilizó la prueba T pareada dentro de cada grupo y, para evaluar posibles asociaciones entre los Grupos Intervención y Control y el nivel de leucocitos (debajo, normal y superior), se utilizó la prueba exacta de Fisher o prueba de Fisher-Freeman-Halton. Resultados Hubo un aumento en el promedio de las células individuales de la serie roja del hemograma, sobre todo en los estándares de hemoglobina de niños desnutridos del Grupo Intervención (p<0,05). La investigación también apuntó una diferencia intragrupo en el parámetro de la hemoglobina, tanto en el Grupo Control (p=0,007) como en la Intervención (p<0,001), así como en el parámetro hematocrito para ambos grupos (p=0,001). Específicamente en la serie blanca, después de la intervención, se evidenció una disminución significativa en los leucocitos (p=0,04) y linfocitos (p<0,01) Conclusión Después de la intervención, la utilización de la harina de la castaña de cajú mejoró los parámetros hematológicos de los niños desnutridos.


Abstract Objective To assess hematological parameters of malnourished children after nutritional intervention with cashew nut flour. Methods This is a randomized, controlled, blind trial. The study was conducted from April to December 2017, in two Basic Health Units. The sample consisted of children under 5 years of age who met the inclusion criteria, 15 in the Intervention Group (cashew nut flour) and 15 children in the Control Group (carboxymethylcellulose flour), randomly allocated to the groups. The parameters of erythrocytes, hemoglobin and hematocrit (red blood cells) and leukocytes, neutrophils, segmented, eosinophils, monocytes and lymphocytes (white blood cells) parameters were analyzed. Blood collection was performed in two moments: the first before intervention implementation and the second after 32 weeks of use of cashew nut flour. To assess the sample normality and homogeneity, Shapiro-Wilk and Bartlett variance tests were used, respectively. The paired t-test was used within each group and, to assess possible associations between the Intervention and Control Groups and the level of leukocytes (below, normal and above), Fisher's Exact test and/or Fisher-Freeman-Halton test were used. Results There was an increase in the mean of the individual red blood cell count, especially in the hemoglobin patterns of malnourished children in the Intervention Group (p<0.05). The investigation also showed an intragroup difference in the hemoglobin parameter, both in the Control Group (p=0.007) and in the Intervention (p<0.001) as well as in the hematocrit parameter for both groups (p=0.001). Specifically in the white blood cells, after intervention, there was a significant decrease in leukocytes (p=0.04) and lymphocytes (p<0.01) Conclusion After intervention, the use of cashew nut flour improved the hematological parameters of malnourished children. Brazilian Clinical Trial Registry (REBEC): U1111.1213.9219


Subject(s)
Humans , Male , Female , Child, Preschool , Blood Cell Count , Child Nutrition Disorders , Random Allocation , Dietary Supplements , Hematologic Tests
8.
Archiv. med. fam. gen. (En línea) ; 18(3): 30-37, Nov. 2021. tab
Article in Spanish | LILACS, InstitutionalDB, BINACIS, UNISALUD | ID: biblio-1395335

ABSTRACT

Introducción: Determinantes sociales y de género, así como las características del barrio de residencia se vinculan con la hipertensión arterial (HTA). Objetivo: Examinar asociaciones de HTA por género en una población socio-segregada de la ciudad de Córdoba, año 2019. Método: Estudio epidemiológico observacional, cuantitativo, de corte transversal. Muestra aleatoria (n = 380) adultos usuarios de un hospital público. Se realizaron mediciones objetivas de tensión arterial y una entrevista sobre características sociodemográficas e indicadores de género. Se realizaron análisis, bivariado y multivariado: modelos regresión logística simple y múltiple; estratificados por género. Resultados: Identificamos determinantes sociales cómo el género asociadas con la HTA; así las mujeres quienes dedicaron mayor tiempo al trabajo no remunerado tuvieron mayores probabilidades de presentar HTA (OR 1,01; IC 95% 1,00- 1,02). Aunque en nuestro estudio la HTA fue mayor en hombres (53,43% vs 36,51% en mujeres); la presentación de HTA en mujeres se asoció a roles de género. La HTA en este espacio segregado fue superior a la prevalencia nacional. Conclusión: HTA varía según el nivel socioeconómico, género, nivel de privación social del barrio (AU)


Introduction: Social and gender determinants, as well as the characteristics of the neighborhood of residence are linked to hypertension (HT). Objective: To examine associations of HT by gender in a socio-segregated population of the city of Córdoba, year 2019. Method:Cross-sectional, quantitative, observational epidemiological study. Random sample (n = 380) adult users of a public hospital. Objective measurements of blood pressure and an interview on sociodemographic characteristics and gender indicators were carried out. Bivariate and multivariate analyzes were performed: simple and multiple logistic regression models; stratified by gender. Results: We identified social determinants such as gender associated with hypertension, women who dedicated more time to unpaid work were more likely to present hypertension (OR 1.01; 95% CI 1.00-1.02). Although in our study, HT was higher in men (53.43% vs 36.51% in women); unlike men, the presentation of HT in women was associated with gender roles. HT in this segregated socio-space was higher than the national prevalence. Conclusion: HT varies according to the socioeconomic level, gender, level of social deprivation of the neighborhood (AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Social Determinants of Health , Hypertension/epidemiology , Argentina/epidemiology , Random Allocation , Logistic Models , Cross-Sectional Studies , Multivariate Analysis , Sex Distribution , Octogenarians , Sociodemographic Factors
9.
RFO UPF ; 26(2): 323-333, 20210808. tab
Article in English | LILACS, BBO | ID: biblio-1452537

ABSTRACT

Objetivo: O objetivo deste estudo foi responder qual é a melhor técnica para remoção de pinos de fibra de vidro e pinos metálicos fundidos considerando tempo, preservação da estrutura dentária e custos. Métodos: Foi realizado um estudo in vitro, randomizado e cego. Sessenta dentes tratados endodonticamente foram randomizados em dois grupos de acordo com o tipo de pino. Uma segunda randomização foi realizada para cada tipo de técnica de remoção (ultrassom, broca ou combinada; n=10). One-way ANOVA foi usado para comparar o tempo de remoção do pino, teste t pareado comparou a quantidade de estrutura dentária removida e Kruskal Wallis seguido pelo teste post hoc de Mann-Whitney foram usados para análise de custo (P = 0,05). Resultados: Não houve diferença no tempo de remoção do pino considerando o tipo ou técnica do pino (P=0,630). A perda média de estrutura dentária na região cervical foi superior a 30% quando apenas uma ponta diamantada foi usada para remover pino de fibra de vidro (P<0,00001) e pino metálico fundido (P=0,008). Conclusão: De acordo com os resultados deste estudo, podemos concluir que a seleção da técnica de remoção dependerá da habilidade do operador, e sempre ocorrerá alguma perda de estrutura dentária, embora seja esperada uma perda maior quando apenas pontas diamantadas são usadas para este fim.(AU)


Objective: The aim of this study was to answer which is the best technique to removing glass fiber post and cast metal post considering time, preservation of tooth structure, and costs. Methods: An in vitro, randomized, blinded study was conducted. Sixty endodontically treated teeth were randomized into two groups according to post type. A second randomization was performed for each type of removal technique (ultrasound, drill, or combined; n=10). One-way ANOVA was used to compare the time to post removal, paired t-test compared the amount of tooth structure removed and Kruskal Wallis followed by post hoc Mann-Whitney test were used for cost analysis (P=0.05). Results: There was no difference in post removal time considering post type or technique (P=0.630). The average loss of tooth structure in the cervical region was greater than 30% when only a diamond bur was used to remove fiber glass post (P<0.00001) and cast metal post (P=0.008). Conclusion: According to the results of this study, we can conclude that the selection of the removal technique will depend on the skill of the operator, and some loss of tooth structure will always occur, although greater loss is expected when only diamond burs are used for this purpose.(AU)


Subject(s)
Humans , Post and Core Technique/economics , Device Removal/economics , Dental Pins/economics , Reference Values , Time Factors , Random Allocation , Analysis of Variance , Statistics, Nonparametric , Costs and Cost Analysis , Device Removal/methods
10.
RFO UPF ; 26(2): 206-212, 20210808. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-1443776

ABSTRACT

Objetivos: avaliar a sujidade de limas rotatórias e reciprocantes após instrumentação e procedimentos de limpeza pré-esterilização. Materiais e métodos: 24 limas rotatórias e as 24 limas reciprocantes foram divididas, aleatoriamente, em dois grandes grupos. No primeiro grupo, as 12 limas rotatórias e as 12 limas reciprocantes foram divididas, aleatoriamente, em seis subgrupos (SG): SG1 (controle negativo 1/n=1) ­ 1 lima rotatória não submetida à instrumentação; SG2 (controle negativo 2/n=1) ­ 1 lima reciprocante não submetida à instrumentação; SG3 (controle positivo 1/n=1) ­ 1 lima rotatória submetida à instrumentação e não submetida a qualquer protocolo de limpeza; SG4 (controle positivo 2/n=1) ­ 1 lima reciprocante submetida à instrumentação e não submetida a qualquer protocolo de limpeza; SG5 (grupo teste/n=10) ­ 10 limas rotatórias submetidas à instrumentação e submetidas ao protocolo de lavagem manual; SG6 (grupo teste/ n=10) ­ 10 limas reciprocantes submetidas à instrumentação e submetidas ao protocolo de lavagem manual. No segundo grupo, as 12 limas rotatórias e as 12 limas reciprocantes foram divididas, aleatoriamente, nos mesmos subgrupos, substituindo, nos subgrupos 5 e 6, a lavagem manual pela lavagem em cuba ultrassônica. A análise do nível de sujidade foi realizada por microscopia eletrônica de varredura (MEV), sendo os dados submetidos ao teste de Kruskal-Wallis, com nível de significância de 5%. Resultados: a menor média de sujidade entre os grupos experimentais foi encontrada no SG5 do G1, sem diferença significante em relação aos demais grupos testados (p>0,05). Conclusão: conclui-se que os protocolos de limpeza testados não foram completamente efetivos para a remoção de sujidade das limas endodônticas.(AU)


Objective: to evaluate the dirt of rotary and reciprocating files after instrumentation and pre- -sterilization cleaning procedures. Materials and Methods: 24 rotary files and the 24 reciprocating files were randomly divided into two groups. In the 1st group, 12 rotary files and 12 reciprocating files were randomly divided into six subgroups (SG): SG1 (negative control 1/n=1) ­ 1 rotary file not subjected to instrumentation; SG2 (negative control 2/n=1) ­ 1 reciprocating file not subjected to instrumentation; SG3 (positive control 1/n=1) ­ 1 rotary file submitted to instrumentation and not submitted to any cleaning protocol; SG4 (positive control 2/n=1) ­ 1 reciprocating file submitted to instrumentation and not submitted to any cleaning protocol; SG5 (test group/n=10) ­ 10 rotary files submitted to instrumentation and submitted to the manual cleaning protocol; SG6 (test group/n=10) ­ 10 reciprocating files submitted to instrumentation and submitted to the manual cleaning protocol. In the 2nd group, the 12 rotary files and the 12 reciprocating files were randomly divided into the same subgroups, substituting, in subgroups 5 and 6, manual with ultrasonic bath cleaning. The analysis of dirt levels was performed by scanning electron microscopy (SEM), being the data submitted to the Kruskal-Wallis test, with a significance level of 5%. Results: the lowest average of dirt between the experimental groups was found in SG5 of G1, with no significant difference when compared to the other groups (p>0.05). Conclusion: it could be concluded that the cleaning protocols were not completely effective in removing dirt from endodontic files.(AU)


Subject(s)
Humans , Sterilization/methods , Root Canal Preparation/instrumentation , Dental Instruments , Reference Values , Microscopy, Electron, Scanning , Random Allocation , Equipment Contamination , Statistics, Nonparametric , Root Canal Preparation/methods
11.
West Indian med. j ; 69(1): 56-59, 2021. tab
Article in English | LILACS | ID: biblio-1341862

ABSTRACT

ABSTRACT Background: Gestational diabetes mellitus is an increasingly frequent metabolic disorder that is important for both baby and mother. New studies on the development and treatment of the disease are required. Objective: To investigate the effects on offspring's survival and the biochemical values of diabetes mellitus, induced by different doses of two chemical agents among 35 rats with advanced pregnancy. Methods: The rats were randomly divided into five groups, with the rats in Group 1 as the control group. Alloxan was administered intraperitoneally at doses of 40 and 60 mg/kg in Groups 2 and 3, respectively. Streptozotocin was injected intraperitoneally at doses of 40 and 60 mg/kg in Groups 4 and 5, respectively. Deliveries were monitored, and offspring numbers, survival rates and congenital anomalies were recorded. At the end of the study, blood was drawn from one female offspring in each group; glucose, total protein, albumin, triglyceride, cholesterol, calcium and phosphorus levels were measured, and inter-group comparisons were made. Diabetic agents administered at various doses prolonged the duration of pregnancy. Results: Offspring's deaths were most frequent in the alloxan groups. The number of offspring mortalities in the streptozotocin group was higher than that of the control group, but lower than that of the alloxan group. No differences in glucose, total protein, albumin, triglyceride, cholesterol, calcium and phosphorus levels were observed between the groups. These results indicate that the female offspring, born from rats with gestational diabetes mellitus induced by different chemicals, were only clinically affected. No effect of the type of chemicals on the results was found. Conclusion: The use of streptozotocin in the studies on female offspring born from rats with gestational diabetes mellitus is recommended.


Subject(s)
Animals , Female , Pregnancy , Rats , Pregnancy Complications , Diabetes Mellitus, Experimental , Animals, Newborn , Random Allocation , Rats, Wistar
12.
Biomedical and Environmental Sciences ; (12): 356-363, 2021.
Article in English | WPRIM | ID: wpr-878371

ABSTRACT

Objective@#This study aimed to investigate the effects of @*Methods@#In this study, 0.1% DMG was supplemented in 20% casein diets that were either folate-sufficient (20C) or folate-deficient (20CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.@*Results@#Folate deprivation significantly increased pHcy concentration in rats fed 20C diet (from 14.19 ± 0.39 μmol/L to 28.49 ± 0.50 μmol/L; @*Conclusion@#DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.


Subject(s)
Animals , Male , Rats , Biomarkers/metabolism , Chromatography, Liquid , Diet , Dietary Supplements , Folic Acid Deficiency/metabolism , Homocysteine/metabolism , Liver/metabolism , Random Allocation , Rats, Wistar , Sarcosine/metabolism
13.
Environmental Health and Preventive Medicine ; : 8-8, 2021.
Article in English | WPRIM | ID: wpr-880327

ABSTRACT

BACKGROUND@#Prenatal stress can cause neurobiological and behavioral defects in offspring; environmental factors play a crucial role in regulating the development of brain and behavioral; this study was designed to test and verify whether an enriched environment can repair learning and memory impairment in offspring rats induced by prenatal stress and to explore its mechanism involving the expression of insulin-like growth factor-2 (IGF-2) and activity-regulated cytoskeletal-associated protein (Arc) in the hippocampus of the offspring.@*METHODS@#Rats were selected to establish a chronic unpredictable mild stress (CUMS) model during pregnancy. Offspring were weaned on 21st day and housed under either standard or an enriched environment. The learning and memory ability were tested using Morris water maze and Y-maze. The expression of IGF-2 and Arc mRNA and protein were respectively measured by using RT-PCR and Western blotting.@*RESULTS@#There was an elevation in the plasma corticosterone level of rat model of maternal chronic stress during pregnancy. Maternal stress's offspring exposed to an enriched environment could decrease their plasma corticosterone level and improve their weight. The offspring of maternal stress during pregnancy exhibited abnormalities in Morris water maze and Y-maze, which were improved in an enriched environment. The expression of IGF-2, Arc mRNA, and protein in offspring of maternal stress during pregnancy was boosted and some relationships existed between these parameters after being exposed enriched environment.@*CONCLUSIONS@#The learning and memory impairment in offspring of prenatal stress can be rectified by the enriched environment, the mechanism of which is related to the decreasing plasma corticosterone and increasing hippocampal IGF-2 and Arc of offspring rats following maternal chronic stress during pregnancy.


Subject(s)
Animals , Female , Male , Pregnancy , Rats , Cytoskeletal Proteins/metabolism , Gene Expression Regulation , Hippocampus/metabolism , Insulin-Like Growth Factor II/metabolism , Learning , Learning Disabilities/psychology , Memory Disorders/psychology , Nerve Tissue Proteins/metabolism , Prenatal Exposure Delayed Effects/psychology , Random Allocation , Rats, Wistar , Social Environment , Stress, Psychological/genetics
14.
Rev. odontopediatr. latinoam ; 11(1): 220160, 2021. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1147621

ABSTRACT

Objetivo: Evaluar la eficacia de la musicoterapia para la reducción de la ansiedad dental en niños entre 5 a 12 años con discapacidad durante la atención odontológica. Materiales y métodos: Estudio cuasi experimental. Se evaluaron 40 pacientes, divididos aleatoriamente en 2 grupos: grupo de expuestos y no expuestos a musicoterapia. El nivel de ansiedad fue registrado por la escala de imagen facial antes y después de la atención clínica, el comportamiento durante la atención a través de la escala de Frankl y el nivel de ansiedad de los padres a través de la escala modificada de Corah. Se registraron las funciones vitales de ambos grupos antes y después de dicha atención. El análisis de los datos se realizó análisis descriptivo (media ± desviación estándar) y análisis inferencial: Test de T-Student y Chi cuadrado (p<0,05). Resultados: Se encontró que la presión arterial inicial/ final en el grupo expuesto fue (Sístole: 108.75 ± 8.56/ 95.50 ± 6.86, Diástole: 67.75 ± 7.15 / 57.75 ± 6.38), y en el grupo no expuesto (Sístole: 101.75 ± 8.77/ 110.15 ± 13.31, Diástole: 59.20 ± 6.08) respectivamente, y la frecuencia cardiaca inicial/final en el grupo expuesto (72.30 ± 7.18 / 63.95 ± 6.12); y en el grupo no expuesto (66.50 ± 9.88 / 73.90 ± 11.46). Se encontraron diferencias estadísticamente significativas en los valores de la presión arterial (sístole, p<0,001 y diástole, p=0,007) y frecuencia cardiaca final (p=0,001), así como una reducción de los niveles de ansiedad final en el grupo expuesto a musicoterapia (p=0,001).


Objetivo:Avaliar a eficacia da musicoterapia para redução da ansiedade dental em crianças com discapacidades entre 5 a 12 anos durante o atendimento odontológico. Materiais e métodos: Estudo quase experimental. Avaliou-se 40 pacientes divididos aleatoriamente em dois grupos: grupos de expostos e não expostos a musicoterapia. O nível de ansiedade foi registrado pela escala de imagem facial antes e durante o atendimento odontológico, o comportamento durante o atendimento foi através da escala de Frankl e o nível de ansiedade dos padres através da escala modificada de Corah. As funções vitais foram registradas antes e depois do atendimento. O análises de dados foi realizado através análises descritivas (média ± ds) e análises inferenciais: Teste de T-Student e Chi Quadrado (p<0,05). Resultados: A pressão arterial inicial/final no grupo exposto foi (Sístole: 108.75 ± 8.56/95.50 ± 6.86, Diástole: 67.75 ± 7.15/ 57.75 ± 6.38), e no grupo não exposto (Sístole: 101.75 ± 8.77/110.15 ± 13.31, Diástole: 59.20 ± 6.08) respetivamente, e a frequência cardíaca inicial/final no grupo exposto (72.30 ± 7.18/ 63.95 ± 6.12); e no grupo não exposto (66.50 ± 9.88 / 73.90 ± 11.46). Se encontraram diferenças estatisticamente significativas nos valores da pressão arterial (sístole, p=0,000 e diástole, p=0,007) e frequência cardíaca final (p= 0,001), assim como na redução dos níveis de ansiedade final no grupo exposto à musicoterapia (p=0,001). Conclusão: O uso da musicoterapia diminuiu significativamente os níveis da ansiedade durante o atendimento odontológico nos pacientes com discapacidades


Objective: To evaluate the effectiveness of music therapy in reducing dental anxiety in children with disabilities between 5 and 12 years old during dental care. Materials and methods: Quasi-experimental study. 40 patients were evaluated, randomly divided into 2 groups: a group exposed to music therapy and a group not exposed to it. The levels of anxiety were registered using the Facial Image Scale before and after the dental care, the behaviour during dental care using the Frank Scale and the level of anxiety of the parents using the Modified Corah Scale. The vital functions of both groups were registered before and after the dental care. The data analysis was performed using descriptive analysis (media ± standard deviation) and inferential analysis: T- Student test and Chi square (p<0,05). Results: It was found that the initial/final blood pressure in the exposed group was (Systole: 108.75 ± 8.56/ 95.50 ± 6.86, Diastole: 67.75 ± 7.15/ 57.75 ± 6.38), and in the unexposed group (Systole: 101.75 ± 8.77/ 110.15 ± 13.31, Diastole: 59.20 ± 6.08), and the initial/final heart rate in the exposed group was (72.30 ± 7.18/ 63.95 ± 6.12); and in the unexposed group (66.50 ± 9.88/ 73.90 ± 11.46). Statistically significant differences were found in the values of blood pressure (systole, p=0,000 y diastole, p=0,007) and heart rate (p= 0,001), as well as a reduction in the levels of anxiety in the exposed group to music therapy (p=0,001). Conclusion: The use of Music therapy significantly reduces levels of anxiety during dental care in patients with disabilities.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Tooth Diseases/therapy , Dental Anxiety/psychology , Dental Care for Children/methods , Disabled Children/psychology , Music Therapy , Blood Pressure , Random Allocation , Down Syndrome/psychology , Cognitive Dysfunction/psychology , Autism Spectrum Disorder/psychology , Heart Rate
15.
Braz. dent. sci ; 24(1): 1-13, 2021. ilus, tab
Article in English | BBO, LILACS | ID: biblio-1141394

ABSTRACT

Objective: to compare the clinical performance of newly introduced resin modified glass ionomer varnish (Clinpro™ XT) versus resin infiltration in treatment of post-orthodontic white spot lesions. Material and Methods: Six participants (70 teeth) were enrolled with post-orthodontic white spot lesions. Randomization was performed according to patient selection for the sealed envelope containing which half will receive the control (resin infiltration (ICON, DMG) and the other will receive the intervention (resin modified glass-ionomer cement varnish (Clinpro™ XT, 3M)). Follow up was done after 1 day, 1 week, 1 month, and 3 months, 6 months and 12 months. The color was assessed by spectrophotometer while the degree of demineralization was measured by Diagnodent pen 2910. Patient satisfaction was assessed using (VAS) Visual analogue scale Results:Regarding color change, significant improvement in lightness for ICON group, while Clinpro™ XT group, the change was insignificant. The demineralization data revealed significant decrease in demineralization with resin infiltration after immediate application. Clinpro™ XT showed also significant decrease after immediate assessment and significant increase in demineralization in 6 and 12 months. Conclusion: Resin infiltration can be considered more as an alternative treatment rather than fluoride varnish. Clinpro™ XTis considered as a preventive protocol, provided that renewal application is needed after 3 months (AU)


Objetivo: comparar o desempenho clínico do recém-introduzido verniz de ionômero de vidro modificado por resina (Clinpro ™ XT) com a infiltração de resina no tratamento de lesões de manchas brancas pós-ortodônticas. Material e Métodos: Seis participantes (70 dentes) foram inscritos com lesões pós-ortodônticas de manchas brancas. A randomização foi realizada de acordo com a seleção do paciente para o envelope lacrado contendo qual metade receberá o controle (infiltração de resina (ICON, DMG) e a outra metade receberá a intervenção (verniz de cimento de ionômero de vidro modificado por resina (Clinpro ™ XT, 3M)). O acompanhamento foi feito após 1 dia, 1 semana, 1 mês e 3 meses, 6 meses e 12 meses. A cor foi avaliada por espectrofotômetro, enquanto o grau de desmineralização foi medido pela caneta Diagnodent 2910. A satisfação do paciente foi avaliada usando (VAS) Escala visual analógica. Resultados: Em relação à mudança de cor, houve uma melhora significativa na luminosidade para o grupo ICON, enquanto o grupo Clinpro ™ XT, a mudança foi insignificante. Os dados de desmineralização revelaram diminuição significativa da desmineralização com infiltração de resina após a aplicação imediata. O grupo Clinpro ™ XT também mostrou diminuição significativa após avaliação imediata e aumento significativo na desmineralização em 6 e 12 meses. Conclusão: A infiltração de resina pode ser considerada mais como uma alternativa de tratamento do que o verniz fluoretado. O Clinpro ™ XT é considerado um protocolo preventivo, uma vez que a renovação é necessária após 3 meses. (AU)


Subject(s)
Humans , Random Allocation , Patient Satisfaction , Resin Cements , Fluorides , Glass Ionomer Cements
16.
Rev. bras. anestesiol ; 70(6): 627-634, Nov.-Dec. 2020. graf
Article in English | LILACS | ID: biblio-1155766

ABSTRACT

Abstract Background and objectives The mechanisms by which local anesthetics cause neurotoxicity are very complicated. Apoptosis and autophagy are highly coordinated mechanisms that maintain cellular homeostasis against stress. Studies have shown that autophagy activation serves as a protective mechanism in vitro. However, whether it also plays the same role in vivo is unclear. The aim of this study was to explore the role of autophagy in local anesthetic-induced neurotoxicity and to elucidate the mechanism of neurotoxicity in an intrathecally injected rat model. Methods Eighteen healthy adult male Sprague-Dawley rats were randomly divided into three groups. Before receiving an intrathecal injection of 1% bupivacaine, each rat received an intraperitoneal injection of vehicle or rapamycin (1 mg.kg-1) once a day for 3 days. The pathological changes were examined by Haematoxylin and Eosin (HE) staining. Apoptosis was analysed by TdT-mediated dUTP Nick-End Labelling (TUNEL) staining. Caspase-3, Beclin1 and LC3 expression was examined by Immunohistochemical (IHC) staining. Beclin1 and LC3 expression and the LC3-II/LC3-I ratio were detected by western blot analysis. Results After bupivacaine was injected intrathecally, pathological damage occurred in spinal cord neurons, and the levels of apoptosis and caspase-3 increased. Enhancement of autophagy with rapamycin markedly alleviated the pathological changes and decreased the levels of apoptosis and caspase-3 while increasing the expression of LC3 and Beclin1 and the ratio of LC3-II to LC3-I. Conclusions Enhancement of autophagy decreases caspase-3-dependent apoptosis and improves neuronal survivalin vivo. Activation of autophagy may be a potential therapeutic strategy for local anaesthetic-induced neurotoxicity.


Resumo Introdução e objetivos Os mecanismos de neurotoxicidade dos anestésicos locais são complexos. A apoptose e a autofagia são mecanismos altamente organizados que mantêm a homeostase celular durante o estresse. Estudos revelam que a ativação da autofagia atua como mecanismo de proteção in vitro. Não está claro se a autofagia também desempenha essa função in vivo. O objetivo deste estudo foi analisar o papel da autofagia na neurotoxicidade induzida por anestésico local e esclarecer o mecanismo dessa neurotoxicidade utilizando um modelo de injeção intratecal em ratos. Métodos Dezoito ratos Sprague‐Dawley machos adultos saudáveis foram divididos aleatoriamente em três grupos. Antes de receber a injeção intratecal de bupivacaína a 1%, cada rato recebeu injeção intraperitoneal de veículo ou rapamicina (1 mg.kg‐1) uma vez ao dia durante 3 dias. As alterações patológicas foram examinadas por coloração com Hematoxilina e Eosina (HE). A apoptose foi analisada por coloração com o método dUTP Nick‐End Labeling (TUNEL) mediado por TdT. A expressão de caspase‐3, Beclin1 e LC3 foram examinadas por coloração Imunohistoquímica (IHQ). A expressão de Beclin1 e LC3 e a razão LC3‐II/LC3‐I foram detectadas por análise de western blot. Resultados Após a injeção intratecal de bupivacaína, ocorreu lesão patológica nos neurônios da medula espinhal e os níveis de apoptose e caspase‐3 aumentaram. A ativação da autofagia causada pela rapamicina mitigou de forma expressiva as alterações patológicas e diminuiu os níveis de apoptose e caspase‐3, aumentando a expressão de LC3 e Beclin1 e a razão LC3‐II/LC3‐I. Conclusões O aumento da autofagia diminui a apoptose dependente da caspase‐3 e melhora a sobrevivência neuronal in vivo. A ativação da autofagia pode ser uma estratégia terapêutica potencial para a neurotoxicidade induzida por anestésicos locais.


Subject(s)
Animals , Male , Rats , Autophagy/drug effects , Bupivacaine/toxicity , Neurotoxicity Syndromes/prevention & control , Caspase 3/metabolism , Anesthetics, Local/toxicity , Neurons/drug effects , Spinal Cord/drug effects , Autophagy/physiology , Bupivacaine/administration & dosage , Random Allocation , Rats, Sprague-Dawley , Apoptosis/drug effects , Sirolimus/administration & dosage , In Situ Nick-End Labeling , Beclin-1/metabolism , Microtubule-Associated Proteins/metabolism , Neurons/pathology
17.
Rev. bras. anestesiol ; 70(6): 635-641, Nov.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1155763

ABSTRACT

Abstract Background and objectives: Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanism of the effects on coagulation are not fully understood. The objective of this research is to evaluate the effects of rocuronium, sugammadex and the rocuronium-sugammadex complex on coagulation in an experimental model in rats. Methods: This is an experimental randomized animal study. Wistar rats were randomly assigned into the following groups: the Control Group; the Ssal Group - 0.5 mL of intravenous saline; the Sugammadex Group - intravenous sugammadex (100 mg kg−1); and the Rocuronium-Sugammadex Group - intravenous solution with rocuronium (3.75 mg kg−1) and sugammadex (100 mg kg−1). Anesthesia was performed by using isoflurane with controlled ventilation. Coagulation factors were measured 10 minutes after the end of the preoperative preparation and 30 minutes after the administration of the drugs in accordance with the chosen groups. Results: Platelet counts, prothrombin times, and activated partial thromboplastin times were similar between the groups and between the moments within each group. There were reductions in the plasma fibrinogen levels between sample times 1 and 2 in the Rocuronium-Sugammadex group (p = 0.035). Conclusions: The rocuronium-sugammadex complex promoted reductions in plasma fibrinogen counts, although the levels were still within normal limits.


Resumo Introdução e objetivos: O sugamadex é uma substância farmacológica alternativa capaz de reverter o bloqueio neuromuscular sem as limitações apresentadas pelos anticolinesterásicos. Entretanto, há relatos de transtornos de coagulação relacionados ao tratamento com sugamadex sem que mecanismos exatos de seus efeitos sobre a coagulação sejam totalmente compreendidos. O objetivo da presente pesquisa foi avaliar os efeitos do rocurônio, sugamadex e do complexo rocurônio-sugamadex sobre a coagulação em um modelo experimental com ratos. Métodos: Este é um estudo randomizado experimental animal. Ratos Wistar foram aleatoriamente designados aos seguintes grupos: grupo controle; Grupo Ssal - 0,5 mL de solução salina intravenosa; Grupo sugamadex - sugamadex intravenoso (100 mg.kg-1); e Grupo rocurônio-sugamadex - solução intravenosa com rocurônio (3,75 mg.kg-1) e sugamadex (100 mg.kg-1). A anestesia foi realizada utilizando-se isoflurano com ventilação controlada. Os fatores de coagulação foram medidos 10 minutos após o final do preparo pré-operatório e 30 minutos após a administração de drogas de acordo com os grupos escolhidos. Resultados: Contagem de plaquetas, tempo de protrombina e tempo de tromboplastina parcial ativada foram semelhantes entre os grupos e entre os momentos dentro de cada grupo. Houve redução nos níveis de fibrinogênio plasmático entre os tempos 1 e 2 no grupo rocurônio-sugamadex (p = 0,035). Conclusões: O complexo rocurônio-sugamadex promoveu reduções na contagem de fibrinogênio plasmático, apesar de os níveis continuarem dentro dos limites normais.


Subject(s)
Animals , Rats , Blood Coagulation/drug effects , Neuromuscular Nondepolarizing Agents/pharmacology , Neuromuscular Blockade , Sugammadex/pharmacology , Rocuronium/pharmacology , Partial Thromboplastin Time , Platelet Count , Prothrombin Time , Fibrinogen/analysis , Random Allocation , Rats, Wistar , Neuromuscular Nondepolarizing Agents/administration & dosage , Anesthetics, Inhalation , Drug Combinations , Sugammadex/administration & dosage , Rocuronium/administration & dosage , Isoflurane , Anesthesia/methods
18.
Rev. bras. ativ. fís. saúde ; 25: 1-7, set. 2020. tab
Article in Portuguese | LILACS | ID: biblio-1128491

ABSTRACT

Distúrbios do equilíbrio consistem em um grande problema na doença de Parkinson (DP). A terapia por vibração do corpo inteiro mostra-se benéfica em pessoas saudáveis, mas apresenta eficácia incerta na DP. O objetivo desse estudo foi verificar os efeitos agudos da terapia por vibração do corpo inteiro sobre o equilíbrio de pacientes com DP e analisar o tamanho do efeito da intervenção para predizer o número ideal de participantes. Doze participantes com DP foram randomicamente divididos entre grupos intervenção e placebo. O grupo intervenção foi submetidos à terapia vibratória, tendo o equilíbrio avaliado em período anterior, imediatamente após e transcorrido cinco minutos da sessão. O grupo placebo fez uma intervenção simulada, tendo o equilíbrio avaliado nos mesmos períodos. Ambos os grupos tiveram seus olhos vendados para manter cegamento dos participantes sobre a intervenção. As variáveis analisadas foram deslocamento, área e velocidade de deslocamento. O tamanho do efeito foi verificado em análises univariadas e multivariadas, admitindo significância em 5%. Sobre os resultados, a terapia por vibração do corpo inteiro não apresentou eficácia sobre o equilíbrio na DP em momento imediato e transcorrido cinco minutos da aplicação da terapia. A análise que apresentou maior tamanho do efeito se deu quando o equilíbrio foi mensurado de forma multivariada, predizendo a necessidade de 46 pacientes. Em conclusão, os resultados desse estudo foram imprecisos quanto à eficácia da terapia por vibração do corpo inteiro no equilíbrio de pacientes com DP. Novas pesquisas com uma amostra superior a 46 participantes devem ser realizadas


Balance disorders are a major problem in Parkinson's disease (PD). The whole body vibration has benefits on the balance in healthy people, but it has imprecise effectiveness in PD. The aim of this study was to verify the effects of whole body vibration on balance in patients with PD and to predict the ideal number of participants from the effects size. Twelve participants with PD were randomly divided into intervention and placebo groups. Participants in the intervention group underwent whole body vibration and the subjects had their balance assessed prior therapy, immediately and five minutes after the session. The control group underwent a placebo intervention and the subjects had their balance assessed on the same periods. Both groups had their eyes closed during the intervention protocol. The variables assessed were body displacement, area and velocity of body displacement. The effect size of the intervention was analysed under univariate and multivariate analyses. Significance was set at 5%. With respect to the results, the whole body vibration was inefficient in improving balance immediately and five minutes after the session. The analysis that presented the strongest effect size occurred when balance was assessed under a multivariate basis, predicting the need of 46 participants. In conclusion, the results were imprecise as to the effects of whole body vibration on the balance in patients with PD. Studies with a sample size higher than 46 participants should be carried out to further address this topic


Subject(s)
Parkinson Disease , Random Allocation , Pilot Projects , Sample Size , Postural Balance
19.
Rev. Pesqui. Fisioter ; 10(3): 512-519, ago.2020. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-1224118

ABSTRACT

Ensaios clínicos randomizados (ECR) são o padrão ouro para desenho experimental de estudo ou ensaio clínico. Apenas por meio de uma investigação do tipo ECR é possível avaliar e demonstrar a relação de causa-e-efeito entre um conjunto de variáveis independentes e dependentes. O ECR adicionou vantagens em relação aos outros modelos experimentais, principalmente devido à presença de um grupo controle. Existem várias críticas à validade interna das pesquisas em saúde, incluindo preconceitos e desvantagens que são apontadas para seu descrédito. OBJETIVO: O objetivo do presente estudo é informar características, vantagens, desvantagens e desvios deste método científico. MATERIAL E MÉTODOS: Análise crítica de método científico com base em revisão narrativa da literatura. Foi consultada a base de dados Medline por meio dos portais PubMed e Scopus, sem data de início e até julho de 2020, para extração das informações relativas aos ECR. Apenas artigos de língua inglesa foram incluídos, usando as palavras-chave "estudo randomizado controlado", "ensaio clínico randomizado", "projeto experimental" e "estudo experimental", intercaladas pelos operadores booleanos "AND ," "OR" e "NOT". Anais de conferências e resumos não foram considerados para a análise dos dados. RESULTADOS: Dos ECR selecionados, foram extraídas características, vantagens, desvantagens, importância e vantagens dos controles em pesquisa, o princípio de equilíbrio, ensaios clínicos randomizados na população pediátrica, ECR na população geriátrica, ameaças à validade interna e medidas para minimização de viéses e preconceitos em ECR. CONCLUSÃO: Tópicos relevantes dos ECR foram explicados nesta revisão que devem guiar pesquisadores clínicos.


Randomized controlled trial (RCT) is the gold standard of experimental design or clinical trial design. Only by RCT in research, the cause-and-effect relationship between a set of independent and dependent variables could be demonstrated. RCT has added advantages over other experimental designs due to the presence of the control group. The importance of control in health research trials and its advantages to be elaborated. Though various threats to internal validity in health research trials could be minimized by RCT, various biases in RCT and disadvantages add to its discredit. OBJECTIVE: The aim of the present narrative review is to brief the characteristics, advantages, disadvantages, and various biases in RCT. METHODS: This review does not follow the PRISMA statement, as it was a narrative review. Two databases, namely, Medline through PubMed and Scopus, were searched from inception to July 2020 for the information pertaining to RCTs and included in this narrative review. Only English language articles were searched with the keywords, "Randomized controlled trial," "Randomized clinical trial," "experimental design," and "experimental study." These keywords are linked together by the Boolean words, "AND," "OR" and "NOT." Conference proceedings and only abstracts were not considered for the review. RESULTS: RCTs were explained under characteristics, advantages, disadvantages, importance, and advantages of controls in research, the principle of equipoise, RCTs in the pediatric population, RCTs in the geriatric population, threats to internal validity and steps to minimize them and various biases in RCTs. CONCLUSION: The narrative presentation of RCTs under various important topics have been explained in this review.


Subject(s)
Randomized Controlled Trial , Research Design , Random Allocation
20.
Arch. endocrinol. metab. (Online) ; 64(3): 251-256, May-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1131079

ABSTRACT

ABSTRACT Objective We aimed to evaluate the impact of minimal extrathyroidal extension (mETE) alone on the risk of recurrence of papillary thyroid carcinoma (PTC). The impact of other factors, including multifocality, age, tumor size, and stimulated thyroglobulin (sTg) values was also assessed. Subjects and methods We retrospectively analyzed 1,108 PTC patients from a medical institution, who presented tumors ≤ 4 cm without any adverse characteristics other than mETE. Patients were classified according to their response to initial treatment 12 to 24 months after surgery as proposed by the 2015 American Thyroid Association (ATA) guideline. Statistical analysis was performed using multivariate logistic regression and receiver operating characteristic (ROC) curve. Results In the multivariate logistic regression analysis, mETE did not have an impact on the response to initial treatment (p = 0.44), similar to multifocality, age, and tumor size. Initial Tg value was the only variable associated with a poor response (p < 0.01, odds ratio = 1.303, 95% confidence interval 1.25-1.36). The ROC analysis revealed that Tg was significant (area under curve = 0.8750); the cutoff value of sTg as a predictor of poor response was 10 ng/mL (sensitivity = 72.2%, specificity = 98.5%). Conclusion For low-risk PTC presenting mETE as the only aggressive feature, the initial sTg value is essential to identify patients who may have a poor response after initial treatment and benefit from further treatment. Arch Endocrinol Metab. 2020;64(3):251-6


Subject(s)
Humans , Male , Female , Adult , Young Adult , Thyroid Neoplasms/pathology , Thyroid Cancer, Papillary/pathology , Thyroidectomy , Thyroid Neoplasms/surgery , Random Allocation , Retrospective Studies , Tumor Burden , Thyroid Cancer, Papillary/surgery , Middle Aged , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Neoplasm Staging
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