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1.
Rev. colomb. neumol ; 34(2): 38-46, July-Dec. 2022.
Article in Spanish | LILACS, COLNAL | ID: biblio-1412775

ABSTRACT

Introducción: la tuberculosis es considerada como un problema de salud pública a nivel mundial, siendo la decimotercera causa de muerte y la enfermedad infecciosa más mortífera detrás del COVID-19 y por encima de la infección por VIH, llegando a un total de 1.5 millones de muertes en el 2020. Colombia es el quinto país de la región con mayor carga de casos de tuberculosis, reportándose en el Programa Nacional de Tuberculosis un total de 13.037 casos preliminares en el 2020, representando una importante carga para el Sistema General de Seguridad Social en Salud. Material y métodos: se realizó un estudio observacional de corte retrospectivo con una población de 130 pacientes con diagnóstico de tuberculosis en una institución de tercer nivel en la ciudad de Bogotá, con el fin de identificar posibles factores de riesgo asociados al desarrollo de complicaciones en estos pacientes. Resultados y discusión: en el grupo total encontramos que la presencia de desnutrición es un factor de riesgo independiente para presentar complicaciones asociadas a la infección por tuberculosis; mediante análisis de regresión condicionada por método exacto se identifica un HR de 2.53 [1.008;6.378] (p 0.002) y HR ajustado de 1.47 [0.400-2.556] (p 0.007). El resto de condiciones no presentaron asociación estadísticamente significativa con el desarrollo de complicaciones en pacientes con diagnóstico de tuberculosis. Conclusiones: en los pacientes con diagnóstico de tuberculosis que asistieron al hospital Santa Clara entre 2017 y 2018, encontramos que un estado nutricional inadecuado tuvo una asociación significativa a la presencia de complicaciones relacionadas con infección por tuberculosis. Otros factores como el nivel de educación, estrato socioeconómico o la presencia de comorbilidades no demostraron una influencia significativa en el objetivo del estudio.


Introduction: Tuberculosis is considered a public health problem worldwide, being the thirteenth cause of death and the deadliest infectious disease behind COVID-19 and above HIV infection, reaching a total of 1, 5 million deaths in 2020. Colombia is the fifth country in the region with the highest burden of tuberculosis cases, reporting a total of 13,037 preliminary cases in 2020 in the National Tuberculosis Program, representing a significant burden for the General System of Social Security in Health. Materials and methods: A retrospective observational study was carried out with a population of 130 patients diagnosed with tuberculosis in a third level institution at Bogotá city, to identify factors associated with the development of complications in tuberculosis patients. Results and discussion: In the total group, the presence of malnutrition is found to be an independent risk factor for tuberculosis complications by means of a conditioned regression analysis using the exact method we found an OR of 2.53 [1.008;6.378] (p 0.00202) and adjusted OR of 1.47 [0.400-2.556] (p 0.007), neither of the other conditions can't be associated with the presence of complications in patients diagnosed with tuberculosis. Conclusions: In patients diagnosed with tuberculosis who attended the Santa Clara hospital between 2017 and 2018, we found that an inadequate nutritional status is associated with the presence of major complications. Other factors such as level of education, socioeconomic status or the presence of comorbidities do not show a significant influence on the objective of the study.


Subject(s)
Humans , Tuberculosis , Communicable Diseases , Risk Factors , Social Security , Public Health , Regression Analysis , Malnutrition
2.
Oncología (Ecuador) ; 32(2): 194-207, 2 de Agosto del 2022.
Article in Spanish | LILACS | ID: biblio-1391903

ABSTRACT

In troducción: Una de cada 18 mujeres desarrolla a lo largo de su vida cáncer de mama, siendo esta la principal causa de muerte por cáncer en mujeres.El propósito del presente estudio fue establecer el valor predictivo de los factores histopatológicos presentes en tumores malignos de mama con recepto-res hormonales positivos Her2 negativo de un grupo de pacientes en un centro de referencia oncológico.Met odología: Este estudio longitudinal se realizó en el Instituto Oncológico Nacional "Dr Juan TancaMa-rengo", de Guayaquil -Ecuador. El período de inclusión del 2007 al 2009 con período de observación hasta diciembre del 2020. Con una muestra no probabilística, se incluyeron mujeres con cáncer de mama, hormonal positivo Her2Neu negativo, que hayan recibido tratamiento adyuvante durante un pe-riodo de seguimiento. Se midieron variables demográficas, clínicas, relacionadas al tumor, clasificación TNM y sobrevida.Se realiza un análisis univariado descriptivo de la muestra, un análisis bivariado, com-parando el grupo de pacientes fallecidas con el grupo de pacientes vivas; un análisis de correlación entre variables en escala; un análisis de supervivencia y finalmente se presenta una regresión COX para pre-decir la supervivencia en base a las variables.R esultados: Ingresaron al estudio 105 pacientes, de 54.1 ± 11.4 años. 58.1% de casos en etapa temprana y 41.9% en etapa localmente avanzada. La sobrevida global (SG) fue de 67.6%a 14 añosy la sobrevida librede progresión (SLP) del 59.05%. La terapia de bloqueo hormonal se asoció con la SLP (R=0.544, P<0.01) y con SG (R=0.399, P<0.05). El compromiso ganglionar en estadio N0 tuvo una SLP de 11.9 ± 0.4 años, en estadio N3 fue de 6.8 ± 1.6 años (P<0.01). El modelo de regresión de Cox para predecir el tiempo de vida libre de progresión o enfermedad fue estadísticamente significativo con la terapia de bloqueo hormonal (R2=0.607, P<0.001) Conclusión: Laterapia de bloqueo hormonal mantenida por más de 5 años tiene un impacto positivo en la supervivencia de las pacientes con cáncer de mama hormonal positivo Her2 Neu negativo


In troduction:One in 18 women develops breast cancer throughout her life, this being the leading cause of death from cancer in women. The purpose of the present study was to establish the predictive value of the histopathological factors present in malignant breast tumors with positive hormone receptors Her2 negative in a group of patients in an oncology reference center.Met hodology: This longitudinal study was conducted at the "Dr. Juan Tanca Marengo" National Oncology Institute in Guayaquil -Ecuador. The inclusion period was from 2007 to 2009, with an observation period until December 2020. With a non-probabilistic sample, women with hormone-positive Her2 Neu negative breast cancer who had received adjuvant treatment during a follow-up period were included. Demo-graphic, clinical, tumor-related, TNM classification and survival variables were measured. A descriptive univariate analysis of the sample is performed, a bivariate analysis comparing the group of deceased patients with the group of living patients; a correlation analysis between variables in scale; a survival analysis; and a COX regression is presented to predict survival based on the variables.R esults: 105 patients,54.1 ± 11.4 years old, entered the study. 58.1% of cases are in the early stage, and 41.9% are in a locally advanced stage. Overall survival (OS) was 67.6% at 14 years, and progression-free survival (PFS) was 59.05%. Hormone blocking therapy was associated with PFS (R=0.544, P<0.01) and OS (R=0.399, P<0.05). Lymph node involvement in stage N0 had a PFS of 11.9 ± 0.4 years; stage N3 was 6.8 ± 1.6 years (P<0.01). The Cox regression model to predict progression-free or disease-free life was statistically significant with hormone blockade therapy (R2=0.607, P<0.001).C o nclusion: Hormone blockade therapy maintained for more than five years positively impacts the sur-vival of patients with hormone-positive Her2 Neu negative breast cancer.


Subject(s)
Breast Neoplasms , Tamoxifen , Survival Analysis , Regression Analysis , Receptor, ErbB-2
3.
Rev. cuba. hematol. inmunol. hemoter ; 38(2): e1503, abr.-jun. 2022. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1408449

ABSTRACT

Introducción: La hemofilia es un trastorno hemorrágico que causa dolor y daños articulares graves. Las personas con esta condición de salud suelen presentar problemas psicosociales como baja autoestima y dificultad para enfrentar la enfermedad, lo cual puede impactar negativamente en su calidad de vida relacionada a la salud (CVRS). Objetivo: Analizar el efecto predictor de la autoestima y las estrategias de afrontamiento hacia la CVRS en personas con hemofilia. Métodos: Estudio cuantitativo, no experimental, de tipo correlacional, con muestra por conveniencia, realizado en 60 participantes con hemofilia, edades comprendidas entre 15 y 67 años (media = 27,43, desviación estándar = 11,32). Se utilizaron los cuestionarios: Calidad de Vida Específica para Hemofilia, Autoestima y Afrontamiento al Dolor Crónico. Se realizaron análisis descriptivos, correlación de Pearson y análisis de regresión lineal múltiple con el método por pasos. Resultados: Se obtuvo que el nivel de CVRS fue mayormente moderado; sin embargo, se observaron niveles bajos en las dimensiones Deporte y tiempo libre y Futuro. La dimensión Éxito de la escala de autoestima correlacionó positivamente con las dimensiones Deporte y tiempo libre (r(60)= 0,59), Salud física (r(60)=0,54) y Autopercepción (r(60)=0,48) de la escala calidad de vida; además de haber mostrado un nivel alto de predicción de la calidad de vida (R 2 = 0,35, p= 0,00). Conclusiones: Se comprobó que la autoestima resulta ser una variable predictora de la CVRS de los pacientes con hemofilia. Se requiere fortalecer la autoestima y la manera de enfrentarse ante el dolor crónico en personas con este padecimiento en pro de su calidad de vida y bienestar(AU)


Introduction: Hemophilia is a bleeding disorder that causes severe pain and damage to the joints. People with this health condition often present psychosocial problems such as low self-esteem and difficulty facing their disease, which can negatively impact their health-related quality of life (HRQoL). Objective: To analyze the predictive effect of self-esteem and coping strategies towards HRQL in people with hemophilia. Methods: This was a quantitative, non-experimental, correlational study, with a convenience sample, carried out in 60 participants with hemophilia, ages between 15 and 67 years (mean = 27.43, standard deviation = 11.32). The Specific Quality of Life for Hemophilia, Self-esteem and Coping with Chronic Pain questionnaires were used. Descriptive analyzes. Pearson correlation and multiple linear regression analysis were performed with the stepwise method. Results: It was found that the level of HRQL was mostly moderate, however, low levels were observed in the Sports and free time and Future dimensions. The Success dimension of the self-esteem scale positively correlated with the Sports and free time dimensions (r(60) = 0.59). Physical health (r(60) = 0.54) and Self-perception (r(60) = 0.48) of the quality of life scale, in addition to having shown a high level of prediction of quality of life (R2 = 0.35, p = 0.00). Conclusions: It was found that self-esteem turns out to be a predictor variable of HRQL in patients with hemophilia. It is necessary to strengthen self-esteem and the way of coping with chronic pain in people with this condition in favor of their quality of life and well-being(AU)


Subject(s)
Humans , Male , Quality of Life , Adaptation, Psychological , Regression Analysis , Chronic Pain , Hemophilia A , Surveys and Questionnaires
4.
Bol. malariol. salud ambient ; 62(1): 32-38, jun, 2022. tab, ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1379293

ABSTRACT

Hay dos tipos principales de tejido adiposo; el subcutáneo, que es menos activo metabólicamente, y el tejido adiposo visceral, que secreta constantemente citocinas inflamatorias y está relacionado a enfermedades metabólicas y cardiovasculares. Nuestro objetivo fue identificar la asociación entre el exceso de grasa visceral y la severidad de enfermedad en pacientes con COVID-19. Se realizó un estudio observacional analítico que incluyó a pacientes con COVID-19 admitidos al Hospital Carrión de Huancayo, Perú. Se utilizó la balanza de bioimpedancia para cuantificar la composición corporal, la variable dependiente fue la severidad de enfermedad. Se utilizó el análisis de regresión logística para determinar la asociación de la grasa visceral y otros parámetros antropométricos con severidad de enfermedad. Se analizaron a 120 personas con COVID-19, la edad promedio fue 50 años, el sexo masculino fue 60%. De acuerdo a los valores de la composición corporal emitidos por el equipo de bioimpedancia: La grasa visceral > 15Kg (OR 7,31; p = 0,001); la grasa corporal total > 35% (OR 5,58; p = 0,009) y el exceso de peso > 20Kg (OR 6,96; p = 0,011) fueron los parámetros asociados a enfermedad severa por COVID-19. La relación positiva entre el perímetro abdominal y la cantidad de grasa visceral fue significativo (p = 0,01). En la composición corporal, el exceso de grasa visceral es el mayor parámetro asociado a enfermedad severa por COVID-19(AU)


There are two main types of adipose tissue; the subcutaneous, which is less metabolically active, and the visceral adipose tissue, which constantly secretes inflammatory cytokines and is related to metabolic and cardiovascular diseases. Our objetive was to identify the association between the excess of visceral fat and disease severity in COVID-19 patients. An analytical observational study was carried out which included patients with COVID-19 admitted to the Carrión Hospital in Huancayo, Peru. The bioimpedance balance was used to quantify the body composition; the dependent variable was the severity of the disease. A logistic regression analysis was used to determine the association of visceral fat and other anthropometric parameters with the severity of the disease. Out of 120 people with COVID-19 were analyzed, the average age was 50 years, the male sex was 60%. According to the body composition values issued by the bioimpedance team: Visceral fat> 15Kg (OR 7.31; p = 0.001); Total body fat> 35% (OR 5.58; p = 0.009) and excess weight> 20Kg (OR 6.96; p = 0.011) were the parameters associated with severe disease due to COVID-19. The positive relationship between abdominal circumference and the amount of visceral fat was significant (p = 0.01). In body composition, excess visceral fat is the main parameter associated with severe COVID-19 disease(AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Aged , Aged, 80 and over , Respiratory Distress Syndrome, Newborn/epidemiology , Intra-Abdominal Fat/physiopathology , COVID-19/physiopathology , COVID-19/epidemiology , Obesity/physiopathology , Peru/epidemiology , Severity of Illness Index , Body Mass Index , Logistic Models , Regression Analysis , Hospitals
5.
Arq. bras. neurocir ; 41(1): 58-69, 07/03/2022.
Article in English | LILACS | ID: biblio-1362088

ABSTRACT

Introduction Vasospasm is a common and potentially devastating complication in patients with subarachnoid hemorrhage, causing high morbidity and mortality. There is no effective and consistent way to prevent or treat cerebral vasospasm capable of altering the morbidity and mortality of this complication. Animal and human studies have attempted to show improvement in aneurysmal vasospasm. Some sought their prevention; others, the treatment of already installed vasospasm. Some achieved only angiographic improvement without clinical correlation, others achieved both, but with ephemeral duration or at the expense of very harmful associated effects. Endovascular techniques allow immediate and aggressive treatment of cerebral vasospasm and include methods such as mechanical and chemical angioplasty. These methods have risks and benefits. Objectives To analyze the results of chemical angioplasty using nitroglycerin (GTN). In addition, to performa comprehensive review and analysis of aneurysmal vasospasm. Methods We describe our series of 77 patients treated for 8 years with angioplasty for vasospasm, either mechanical (with balloon), chemical (with GTN) or both. Results Eleven patients received only balloon; 37 received only GTN; 29 received both. Forty-four patients (70.1%) evolved with delayed cerebral ischemia and 19 died (mortality of 24.7%). Two deaths were causally related to the rupture of the vessel by the balloon. The only predictors of poor outcome were the need for external ventricular drainage in the first hours of admission, and isolated mechanical angioplasty. Conclusions Balloon angioplasty has excellent results, but it is restricted to proximal vessels and is not without complications. Chemical angioplasty using nitroglycerin has reasonable but short-lived results and further research is needed about it. It is restricted to vasospasm angioplasties only in hospitals, like ours, where better and more potent vasodilator agents are not available.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Nitroglycerin/therapeutic use , Angioplasty, Balloon/methods , Vasospasm, Intracranial/diagnosis , Vasospasm, Intracranial/physiopathology , Vasospasm, Intracranial/therapy , Subarachnoid Hemorrhage/therapy , Vasodilator Agents/therapeutic use , Chi-Square Distribution , Survival Analysis , Regression Analysis , Data Interpretation, Statistical
6.
Rev. chil. obstet. ginecol. (En línea) ; 87(1): 11-18, feb. 2022. ilus, tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388705

ABSTRACT

OBJETIVO: Evaluar los factores sociales y demográficos asociados al embarazo y al embarazo repetido en mujeres adolescentes de Perú MÉTODO: Estudio transversal analítico realizado a partir de las encuestas de población ENDES 2009 a 2018 en Perú. Participaron mujeres adolescentes entre 12 y 19 años de edad. Se recogió información de condición de embarazo y características sociales y demográficas. Se aplicó la prueba de χ2 y se calculó la razón de prevalencia ajustada con su intervalo de confianza al 95% usando regresión de Poisson con varianza robusta. RESULTADOS: En el estudio se incluyeron 49 676 mujeres adolescentes. El 12,6% tuvieron un embarazo y el 5,1% tuvieron dos o más embarazos. Se evidenció asociación entre edad, región geográfica, origen étnico, nivel educativo, nivel económico y embarazo adolescente (p < 0,001). Los niveles educativo y económico inferiores presentaron una mayor razón de prevalencia de embarazo adolescente, siendo mayor incluso en situaciones de dos o más embarazos. CONCLUSIONES: En la población de mujeres adolescentes de Perú, el 17,7% estuvieron embarazadas y el 5,1% tuvieron embarazo repetido. Existe asociación entre embarazo adolescente y bajos niveles económico y educativo; esta asociación se incrementa en situaciones de embarazo repetido.


OBJECTIVE: To assess the social and demographic factors associated with pregnancy and repeated pregnancy in adolescent women in Peru. METHOD: Analytical cross-sectional study carried out from the ENDES population surveys 2009 to 2018 in Peru. Adolescent women between 12 and 19 years of age participated. Information on pregnancy status and number of children was collected, as well as social and demographic characteristics. The χ2 test was applied, the adjusted prevalence ratio with its 95% confidence interval was calculated using Poisson regression with robust variance. RESULTS: 49 676 adolescent women were included in the study. The 17.7% had one or more pregnancies and 5.1% two or more pregnancies. The analysis showed an association between geographic region, age, ethnic origin, educational level, economic level and adolescent pregnancy (p < 0.001). The lower levels of educational level and economic level presented a higher prevalence ratio of adolescent pregnancy, being higher even in situations of two or more pregnancies. CONCLUSIONS: In the population of adolescent women in Peru, 17.7% were pregnant and 5.1% had repeated pregnancy. Adolescent pregnancy is associated with low economic and educational levels; this association increases in situations of repeated pregnancy.


Subject(s)
Humans , Female , Pregnancy , Child , Adolescent , Young Adult , Pregnancy in Adolescence/statistics & numerical data , Parity , Peru/epidemiology , Socioeconomic Factors , Demography , Cross-Sectional Studies , Multivariate Analysis , Regression Analysis
7.
Psico USF ; 27(1): 143-156, jan.-mar. 2022. tab
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1376036

ABSTRACT

A aposentadoria requer a reorganização de prioridades, atividades e papéis de vida. A teoria da continuidade considera que essa reorganização será maior quando a carreira profissional é uma prioridade pessoal ou quando objetivos de carreira não foram alcançados. Medidas de saliência de carreira, realização de carreira, ajustamento na aposentadoria, percepções de saúde, recursos financeiros e senso de domínio foram respondidas por 454 aposentados, com idade média de 64 anos, 66% mulheres, ativos e inativos. Realização e saliência de carreira explicaram o ajustamento para além dos dados demográficos e dos recursos financeiros e de saúde. A realização de carreira elevou o ajustamento em aposentados inativos e o prejudicou em aposentados ativos. Houve efeito supressor da saliência de carreira sobre a influência da realização de carreira no ajustamento. Conclui-se que a saliência e a realização de carreira são variáveis a serem levadas em consideração no planejamento de programas de preparação para a aposentadoria (AU).


Retirement is a transition that requires reorganizing priorities, routines, activities, and life roles. The continuity theory considers that this reorganization will be all the greater when the professional career is a priority or when career goals have not been achieved. Measures of career salience, career achievement, retirement adjustment, perceptions of health, financial resources, and mastery were answered by 454 retirees, with a mean age of 64, active and inactive, of which 66% were women. Career achievement and career salience explained the adjustment beyond demographic data and financial and health resources. Career achievement increased the adjustment in inactive retirees and impaired it in active retirees, revealing a moderating effect of post-retirement activity. There was a suppressive effect of career salience on the influence of career achievement on adjustment. It is concluded that salience and career achievement are variables to be taken into account when planning retirement preparation programs (AU).


La jubilación es una transición que requiere la reorganización de prioridades, rutinas, actividades y roles vitales. La teoría de la continuidad considera que esta reorganización será aún mayor cuando la carrera laboral sea una prioridad o cuando no se hayan alcanzado los objetivos profesionales. Medidas de prominencia de carrera, realización laboral, ajustamiento a la jubilación, percepciones de salud, recursos financieros y dominio fueran respondidas por 454 jubilados, con una edad media de 64 años, 66% mujeres, activos e inactivos. Realización y la prominencia de carrera explican el ajuste más allá de los datos demográficos y de los recursos financieros y de salud. La realización laboral aumentó el ajuste en los jubilados inactivos y lo perjudicó en los jubilados activos. Hubo un efecto supresor de la prominencia de carrera en la influencia de la realización laboral en el ajuste. Se concluye que la realización y la prominencia de carrera son variables a tener en cuenta al planificar los programas de preparación para la jubilación (AU).


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Retirement/psychology , Social Adjustment , Employment/psychology , Regression Analysis
8.
São Paulo; s.n; s.n; 2022. 88 p. tab, graf.
Thesis in Portuguese | LILACS | ID: biblio-1390664

ABSTRACT

Planejamento de Experimentos (DoE) permite obter e explorar conhecimentos sobre inúmeros sistemas, facilitando a coleta de informações com reduzido número de experimentos. No entanto, DoE é restrito ao delineamento do desenho experimental. Para superar essa limitação e permitir uma previsão precisa dos tempos de retenção para uma seleção de filtros UV orgânicos sob diversas condições, usamos a Relação Quantitativa entre Estrutura e Retenção combinada com o método de Monte Carlo para desenvolver uma plataforma in silico capaz de prever o perfil cromatográfico de filtros UV orgânicos. Sete analitos foram usados para estabelecer o modelo de predição: benzofenona-3, avobenzona, ethilhexil triazona, octil dimetil PABA, metoxicinamato de octila, tinosorb® S e octocrileno. Os valores residuais obtidos no modelo de análise de regressão múltipla mostraram distribuição normal, homocedasticidade e independência. Os coeficientes de determinação (R2) e predição (R2 pred) foram de 99,82% e 99,71%, respectivamente. A plataforma in silico apresentou grande potencial para predição do perfil cromatográfico de filtros UV orgânicos, da coeluição de analitos, de seus parâmetros cromatográficos, além de permitir, sem experimentação, uma visão geral do comportamento de retenção de compostos sob diversas condições cromatográficas


Design of Experiments (DoE) allows obtaining and explorer knowledge about innumerous systems, facilitating the information collection with reduced number of experiments. However, DoE is restricted to the limited range which experimental design was delineated. In order to overcome this limitation and enable accurate prediction of retention times for a selection of organic UV filters under various conditions, we used the Quantitative Structure-Retention Relationships tool combined with Monte Carlo method to develop an in silico platform capable of predicting chromatographic profile of organic UV filters. Seven analytes were used to established to prediction model: benzophenone-3, butyl methoxydibenzoilmethane, ethylhexyl triazone, ethylhexyl dimetyl PABA, ethylhexyl methoxycinnamate, bisethylhexyloxyphenol methoxyphenyl triazine and octocrylene. Residual values obtained from multiple regression analysis model showed normal distribution, homoscedasticity, and independence. Determination (R2) and prediction (R2 pred) coefficients were found to be 99,82% and 99,71%, respectively. In silico platform presented great potential for predicting chromatographic profile of organic UV filters, analytes coelution, chromatographic parameters and allowing, without experimentation, an overview of retention behavior of compounds under various chromatographic conditions


Subject(s)
Sunscreening Agents , Regression Analysis , Chromatography, Liquid/methods , Planning , Methods , Filters , Monte Carlo Method
9.
Article in English | WPRIM | ID: wpr-927628

ABSTRACT

OBJECTIVE@#This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index (BMI) or fat mass percentage and metabolic health status with the ten-year risk of cardiovascular disease (CVD) among Chinese adults.@*METHODS@#Data were obtained from a cross-sectional study. BMI and body fat mass percentage (FMP) combined with the metabolic status were used to define metabolic phenotypes. Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk.@*RESULTS@#A total of 13,239 adults aged 34-75 years were included in this study. Compared with the metabolically healthy non-obese (MHNO) phenotype, the metabolically unhealthy non-obese (MUNO) and metabolically unhealthy obese (MUO) phenotypes defined by BMI showed a higher CVD risk [odds ratio, OR (95% confidence interval, CI): 2.34 (1.89-2.89), 3.45 (2.50-4.75), respectively], after adjusting for the covariates. The MUNO and MUO phenotypes defined by FMP showed a higher CVD risk [ OR (95% CI): 2.31 (1.85-2.88), 2.63 (1.98-3.48), respectively] than the MHNO phenotype. The metabolically healthy obese phenotype, regardless of being defined by BMI or FMP, showed no CVD risk compared with the MHNO phenotype.@*CONCLUSION@#General obesity without central obesity does not increase CVD risk in metabolically healthy individuals. FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk. Obesity and metabolic status have a synergistic effect on CVD risk.


Subject(s)
Adipose Tissue/anatomy & histology , Adult , Aged , Body Mass Index , Cardiovascular Diseases/etiology , China/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Metabolic Diseases/etiology , Middle Aged , Obesity/complications , Phenotype , Regression Analysis , Risk Factors
10.
Chinese Journal of Epidemiology ; (12): 739-746, 2022.
Article in Chinese | WPRIM | ID: wpr-935453

ABSTRACT

Objective: To introduce and compare four analysis methods of multiple parallel mediation model, including pure regression method, method based on inverse probability weighting, extended natural effect model method and weight-based imputation strategies. Methods: For the multiple parallel mediation model, the simulation experiments of three scenarios were carried out to compare the performance of different methods in estimating direct and indirect effects in different situations. Dataset from UK Biobank was then analyzed by using the four methods. Results: The estimation biases of the regression method and the inverse probability weighting method were relatively small, followed by the extended natural effect model method, and the estimation results of the weight-based imputation strategies were quite different from the other three methods. Conclusions: Different multiple parallel mediation analysis methods have different application situations and their own advantages and disadvantages. The regression method is more suitable for continuous mediator, and the inverse probability weighting method is more suitable for binary mediator. The extended natural effect model method has better performances when the residuals of two parallel mediators are positively correlated and the correlation degree is small. The weight-based imputation strategies might not be appropriate for parallel mediation analysis. Therefore, appropriate methods should be selected according to the specific situation in practice.


Subject(s)
Bias , Computer Simulation , Humans , Mediation Analysis , Models, Statistical , Probability , Regression Analysis , Research Design
11.
Chinese Journal of Epidemiology ; (12): 403-408, 2022.
Article in Chinese | WPRIM | ID: wpr-935403

ABSTRACT

Reduced rank regression is an extended multivariate linear regression model with the function of dimension reduction. It has been more and more widely used in nutritional epidemiology research to understand people's dietary patterns in recent years. However, there has been no existing Stata package or command to implement reduced rank regression independently. Therefore, we developed a new user-written package named "rrr" for its implementation in Stata. This paper summarizes the methodology of reduced rank regression, the development and functions of the Stata rrr package and its application in the China Kadoorie Biobank dataset, with the aim of facilitating the future wide use of this statistical method in epidemiology and public health research.


Subject(s)
China , Humans , Models, Statistical , Public Health , Regression Analysis
12.
Chinese Journal of Epidemiology ; (12): 354-358, 2022.
Article in Chinese | WPRIM | ID: wpr-935395

ABSTRACT

Objective: To understand the characteristics and trend of the premature death rate of 4 major chronic diseases in Ji'nan from 2015 to 2020. Methods: The death cause surveillance data and population data during 2015-2020 in Ji'nan were collected, and abbreviated life table, Joinpoint regression analysis and other methods were used to analyze the characteristics and change trends of the premature death rates of 4 major chronic diseases. Results: The crude mortality rate and age standardized mortality rate changes for the 4 major chronic diseases from 2015 to 2020 range from 568.65/100 000 to 604.06/100 000 and 366.77/100 000 to 432.48/100 000, respectively. The annual premature death rate of 4 major chronic diseases declined by 3.33% averagely from 2015 to 2020 (95%CI: -6.25%--0.32%), which might be explained by the declines of the premature death rates of cardiovascular and cerebrovascular diseases [average annual percentage change (AAPC)=-3.23%, 95%CI: -6.32%--0.05%] and cancer (AAPC=-3.58%,95%CI:-6.83%--0.21%). The average decline rate in women (AAPC=-4.19%,95%CI:-7.56%- -0.70%) was higher than that in men (AAPC=-2.92%,95%CI: -5.65%--0.11%). Conclusions: The premature death rate of 4 major chronic diseases showed a downward trend in Ji'nan from 2015 to 2020. Men should be considered as a key population in the prevention and control of 4 major chronic diseases, and attention should also be paid to the non-significant declines in the premature death rates of chronic respiratory diseases and diabetes.


Subject(s)
Cerebrovascular Disorders , Chronic Disease , Diabetes Mellitus , Female , Humans , Male , Mortality, Premature , Regression Analysis
13.
Pesqui. bras. odontopediatria clín. integr ; 22: e210131, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1365225

ABSTRACT

Abstract Objective: To analyze and compare changes of quality of life parameter among dental patients rehabilitated by the implant-supported overdentures with different attachment systems. Material and Methods: Forty-eight patients were recruited as a study cohort. The implant placement procedure was based on the results obtained by CBCT scanning and individualized surgical templates manufactured for correct implant placement. Each individual received two k3Pro Implants (Sure Type with 4.0 or 4.5 mm in diameter) at the intraforaminal area due to standard protocol of implantation provided by the manufacturer under local anesthesia. All patients were distributed between two groups based on the fact of using either Locator- or ball-attachments. Rank correlation was measured using Spearman correlation coefficient, while linear correlation was evaluated by Pearson correlation coefficient. Results: No statistically meaningful differences were noted regarding patients' distribution among groups considering age (p>0.05) and gender (p>0.05). Provided patient-level analysis demonstrated that increase of conventional full denture service time was positively correlated with escalation of OHIP-EDENT scores. The most prominent inter-correspondences were noted specifically between longevity of denture service and elevation of scores within "Functional limitation" (r=0.61; p<0.05), "Physical pain" (r=0.51; p<0.05) and "Physical disability" (r=0.57; p<0.05) subdomains. No statistically argumented regressions were noted between increase tendency of OHIP-EDENT scores and gender (p>0.05) or age (p>0.05) parameters. Conclusion: Significant improvements of quality of life measured with OHIP-EDENT were noted for both types of attachments compared to the pre-treatment situation independently of additionally provided surface electromyography-based alignment.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Quality of Life , Dental Prosthesis, Implant-Supported/instrumentation , Electromyography/instrumentation , Masticatory Muscles , Ukraine , Surveys and Questionnaires , Regression Analysis , Cohort Studies , Statistics, Nonparametric , Occlusal Adjustment , Adaptation to Disasters , Dental Implantation , Denture, Complete , Denture, Overlay
14.
Article in English | LILACS, BBO | ID: biblio-1365233

ABSTRACT

ABSTRACT Objective To determine the relationship between dental anxiety and self-reported periodontal status. Material and Methods The study was conducted among 263 patients at the Family Medicine Clinic of the Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria. Self-assessed gingival and periodontal disease was measured using the validated periodontal disease self-report surveillance questionnaire. The Modified Dental Anxiety Scale (MDAS) was used for evaluating dental anxiety. Student's t-test was used to test for association between categorical variables. P-value < 0.05 was considered to be statistically significant. Results Seventy-seven (29.3%) participants had high dental anxiety, while 49 (18.6%) had very high dental anxiety. The prevalence of periodontal disease was higher among those with very high dental anxiety (77.6%), while female respondents had a significantly higher proportion of self-reported periodontitis (34.1%). There was a significantly higher prevalence of very high dental anxiety among respondents who had never visited the dentist (23.2%). Similarly, females (19.4%), middle-class respondents (30.8%), and those with a primary level of school education (23.5%) had a higher prevalence of high dental anxiety, even though the association was not significant. Conclusion The prevalence of self-reported periodontal disease among the respondents with very high dental anxiety was higher than in those with high dental anxiety and those without dental anxiety, but the difference was not significant.


Subject(s)
Humans , Male , Female , Adult , Periodontal Diseases/prevention & control , Oral Health/education , Dental Anxiety , Self Report , Nigeria/epidemiology , Periodontitis , Prevalence , Multivariate Analysis , Surveys and Questionnaires , Regression Analysis , Data Interpretation, Statistical , Dentists
15.
Pesqui. bras. odontopediatria clín. integr ; 22: e210076, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1365222

ABSTRACT

ABSTRACT Objective To evaluate the frequency of occupational hazards and the criteria for their prevention among Iranian dentists. Material and Methods This cross-sectional study was conducted on 187 general dentists in Kerman. The data collection tool was a questionnaire including personal information (gender, age, marital status, condition and place and years of employment, and the average of weekly working hours) and a valid and reliable questionnaire of occupational hazards, including 24 questions about occupational hazards (6 domain) and nine questions about criteria for the prevention of the risks of dentistry. The t-test, chi-square, and linear regression were used. Results 92 (49.2%) were men. The mean and standard deviation of the score of occupational hazards was 27.04±16.21 out of 96, and the criteria of prevention were 22.00±7.28 out of 36. Regression analysis showed significant correlations between single statuses, years of occupational and type of employment, weekly work hours and occupational hazards, participation in occupational injury identification courses, and hepatitis vaccination. In addition, there were significant correlations between gender, age, weekly work hours, and preventive measures. Moreover, 3.2% of dentists were in a high-risk group and 26.2% were weak in preventive measures. Conclusion A total of 32.6% of dentists are at moderate risk of occupational hazards, and 10.7% meet the prevention criteria properly. It is recommended to hold training classes to identify occupational hazards and the criteria for their prevention among dentists.


Subject(s)
Humans , Male , Female , Adult , Occupational Risks , Risk Factors , Dentists , Iran/epidemiology , Occupational Diseases/etiology , Occupational Dentistry/instrumentation , Chi-Square Distribution , Linear Models , Cross-Sectional Studies/methods , Surveys and Questionnaires , Regression Analysis , Occupational Health , Disease Prevention , Occupational Injuries
16.
Article in English | LILACS, BBO | ID: biblio-1386807

ABSTRACT

Abstract Objective: To evaluate the impact of daily toothbrushing frequency on parental reports of dental pain and discomfort in preschoolers. Material and Methods: An observational cross-sectional study was conducted involving 376 children between four and five years of age at public preschools in the city of Campo Magro, Brazil. Parents/guardians answered a socioeconomic questionnaire that contained a single question on the child's daily toothbrushing frequency and the Brazilian version of the Dental Discomfort Questionnaire (DDQ-B). Statistical analysis involved bivariate and multivariate Poisson regression analyses (α=0.05). Results: After the adjustments in the multivariate analysis, the prevalence of dental pain and discomfort was lower among children whose last visit to the dentist was for prevention (PR = 4.42; 95% CI: 1.75- 11.14; p=0.002) and those with a higher daily toothbrushing frequency (PR = 2.13; 95% CI: 1.12-4.05; p=0.021). Conclusion: A lower toothbrushing frequency is associated with parental reports of dental pain and discomfort in preschoolers. Educational and preventive measures that stimulate an increase in daily toothbrushing frequency can contribute to a better oral health status in preschoolers, consequently, less prevalence of dental pain and discomfort.


Subject(s)
Humans , Male , Female , Child, Preschool , Toothache/prevention & control , Toothbrushing/methods , Oral Health/education , Health Education, Dental , Pediatric Dentistry , Parents , Socioeconomic Factors , Child, Preschool , Cross-Sectional Studies/methods , Multivariate Analysis , Surveys and Questionnaires , Regression Analysis , Data Interpretation, Statistical , Dentists
17.
Texto & contexto enferm ; 31: e20200525, 2022. tab
Article in English | LILACS, BDENF | ID: biblio-1357477

ABSTRACT

ABSTRACT Objective: determining the multidimensional factors associated with the severity of chronic back pain is essential to design appropriate interventions. The objective of this study was to assess the physical and emotional factors associated with the severity of chronic back pain in adults. Method: a descriptive, analytical and cross-sectional study, carried out between November 2017 and December 2018 in Family Health Strategies, with 198 adults with chronic back pain. Pain severity, assessed by the Brief Pain Inventory, was considered the outcome variable; and the pain interference in daily activities (Brief Pain Inventory), physical disability (Roland Morris Disability Questionnaire), quality of life (World Health Organization Quality of Life-Brief) and pain threshold (digital algometer) variables were considered explanatory. A Multivariate Multiple Linear Regression analysis, using the stepwise method with 5% significance, was preformed to establish an explanatory model of pain severity. Results: the mean age was 48.03 years old (standard deviation: 12.41). Most of the participants were women, married and worked. The variables that had a significant and joint impact on pain severity were pain interference in daily activities (parameter: 0.196; p-value<0.001) and in mood (parameter: 0.054; p-value=0.039) and physical domain of quality of life (parameter: -0.032; p-value<0.001). Conclusion: physical factors (pain interference in daily activities and physical domain of quality of life) and emotional factors (pain interference in mood) play an important role in the severity of chronic back pain, which reinforces its multidimensional character.


RESUMEN Objetivo: determinar los factores multidimensionales asociados a la gravedad del dolor de espalda crónico es esencial para diseñar intervenciones apropiadas. El objetivo de este estudio fue evaluar los factores físicos y emocionales asociados a la gravedad del dolor de espalda crónico en adultos. Método: estudio descriptivo y analítico, de corte transversal, realizado entre noviembre de 2017 y diciembre de 2018, en unidades de la Estrategia de Salud Familiar, con 198 adultos que sufren dolor de espalda crónico. La gravedad del dolor, evaluada por medio del Brief Pain Inventory, se consideró como variable de resultado; y las variables interferencia del dolor en las actividades cotidianas (Brief Pain Inventory), discapacidad física (Cuestionario de Discapacidad de Roland Morris), calidad de vida (World Health Organization Quality of Life-Brief) y umbral de dolor (algómetro digital) se consideraron como variables explicativas. Se realizó un análisis multivariado de Regresión Lineal Múltiple, usando el método stepwise con 5% de significancia, para establecer el modelo explicativo de la gravedad del dolor. Resultados: la media de edad fue de 48,03 años (desviación estándar: 12,41). La mayoría de los participantes fueron mujeres, casadas y con alguna actividad laboral. Las variables que ejercieron un impacto sobre la gravedad del dolor en forma significativa y conjunta fueron las siguientes: interferencia del dolor en las actividades cotidianas (parámetro: 0,196; valor p<0,001) y en el estado de ánimo (parámetro: 0,054; valor p=0,039) y el dominio físico de la calidad de vida (parámetro: -0,032; valor p<0,001). Conclusión: los factores físicos (interferencia del dolor en las actividades cotidianas y el dominio físico de la calidad de vida) y emocionales (interferencia del dolor en el estado de ánimo) desempeñan un rol importante en la gravedad del dolor de espalda crónico, lo que refuerza su carácter multidimensional.


RESUMO Objetivo: determinar os fatores multidimensionais associados à severidade da dor crônica nas costas é essencial para traçar intervenções apropriadas. O objetivo deste estudo consistiu em avaliar os fatores físicos e emocionais associados à severidade da dor crônica nas costas em adultos. Método: estudo descritivo analítico, de corte transversal, realizado entre novembro de 2017 e dezembro de 2018, em Estratégias de Saúde da Família, com 198 adultos com dor crônica nas costas. A severidade da dor, avaliada pelo Brief Pain Inventory, foi considera variável de desfecho; as variáveis interferência da dor nas atividades cotidianas (Brief Pain Inventory), incapacidade física (Questionário de Incapacidade de Rolland Morris), qualidade de vida (World Health Organization Quality of Life-Brief) e limiar de dor (algômetro digital) foram consideradas variáveis explicativas. Análise multivariada de Regressão Linear Múltipla, usando o método stepwise com 5% de significância, foi conduzida para estabelecer modelo explicativo da severidade da dor. Resultados: a média de idade foi de 48,03 anos (desvio padrão: 12,41). A maioria eram mulheres, casadas e que trabalhavam. As variáveis que tiveram impacto na severidade da dor de forma significativa e conjunta foram interferência da dor nas atividades cotidianas (parâmetro: 0,196; valor p<0,001) e no humor (parâmetro: 0,054; valor p=0,039) e domínio físico da qualidade de vida (parâmetro: -0,032; valor p<0,001). Conclusão: fatores físicos (interferência da dor nas atividades cotidianas e domínio físico da qualidade de vida) e emocionais (interferência da dor no humor) desempenham importante papel na severidade da dor crônica nas costas, o que reforça o seu caráter multidimensional.


Subject(s)
Humans , Pain Measurement , Regression Analysis , Back Pain , Chronic Pain , Activities of Daily Living , Cross-Sectional Studies , Multivariate Analysis , Nursing , National Health Strategies
18.
Ciênc. rural (Online) ; 52(10): e20210403, 2022. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1364724

ABSTRACT

The plants physiological processes such as transpiration and photosynthetic efficiency are directly related to leaf area, which is difficult to quantify in a nondestructive manner. To generate a model to estimate the total leaf area of plants of banana cv. Vitória, simple and multiple linear regressions utilizing the length and width of the third leaf, the product of length and width of the third leaf, and the total number of leaves of 'Vitória' plants, were tested. The data to develop the model were obtained from 'Vitória' banana plants from different edafoclimatic conditions and management. The best performance of the model was obtained using stepwise multiple regression with r2=0.93 and r2= 0.94. Validation of the model resulted in an r2 of 0.74.


Processos fisiológicos das plantas como transpiração e eficiência fotossintética estão diretamente relacionados à área foliar, a qual é difícil quantificar de forma não destrutiva. Para gerar um modelo para estimar a área foliar total de plantas da cv. Vitória, foram testadas regressões lineares simples e múltiplas utilizando comprimento e largura da terceira folha, o produto comprimento e largura da terceira folha e número total de folhas. Os dados para desenvolver o modelo foram obtidos de cultivos com diferentes condições edafoclimáticas e de manejo. O melhor modelo foi obtido por meio de regressão múltipla stepwise com r2 = 0,93 e r2 = 0,94. A validação do modelo resultou em r2 de 0,74.


Subject(s)
Plant Leaves/anatomy & histology , Musa/anatomy & histology , Genotype , Regression Analysis
19.
Ciênc. rural (Online) ; 52(10): 20210022, 2022. tab
Article in English | LILACS, VETINDEX | ID: biblio-1364721

ABSTRACT

This research analyzed the efficiency situation of corn farms operating in the Adana province of Turkey. In this context, required farm management data were collected from 111 corn farmers by using face to face survey method during the 2019-2020 cultivation season. To determine the technical efficiency (TE) levels of corn farms, Data Envelopment Analysis (DEA) was applied. Furthermore, factors that cause the inefficiency in corn farms were detected by using the Tobit regression model. According to research results, the average TE levels of corn farms in the research area under the variable return to scale conditions are reported as 0.887 (111 farms). These results suggested that if farms reduced their input use by 11.3% on average, they can achieve the same output level and be able to reach full technical efficiency. The most ineffective source in terms of farms performance is machine expenditures with 68.2% of excessive use followed by labor use. In this regard, mechanization modernization, education and training of the labor force and more sensitive fertilizers and pesticide use can increase the efficiency of corn farms. Results of the Tobit regression model indicated that factors such as experience, education, number of tractors and size of the irrigated area positively influenced the TE, whereas family size in corn farming has a negative effect.


Esta pesquisa tem como objetivo analisar a situação de eficiência das fazendas de milho operando na província de Adana, na Turquia. Neste contexto, os dados necessários de gestão da fazenda foram coletados de 111 produtores de milho usando o método de pesquisa frente a frente durante a temporada de cultivo de 2019-2020. Para determinar os níveis de eficiência técnica (TE) das fazendas de milho, foi aplicada a Análise Envoltória de Dados (DEA). Além disso, os fatores que causam a ineficiência nas fazendas de milho foram detectados por meio do modelo de regressão Tobit. De acordo com os resultados da pesquisa, os níveis médios de TE das fazendas de milho na área de pesquisa sob as condições de retorno variável à escala são encontrados em 0,887 (111 fazendas). Esses resultados sugerem que, se as fazendas reduzirem o uso de insumos em 11,3% em média, podem atingir o mesmo nível de produção e alcançar eficiência técnica plena. A fonte mais ineficaz em termos de desempenho das fazendas são os gastos com máquinas, com 68,2% do uso excedente continuado com o uso de mão de obra. Nesse sentido, a mecanização, a modernização, a educação e o treinamento da força de trabalho e o uso de fertilizantes e pesticidas mais sensíveis podem ser sugeridos para aumentar a eficiência das fazendas de milho. Os resultados do modelo de regressão Tobit indicam que fatores como experiência, escolaridade, número de tratores e tamanho da área irrigada influenciaram positivamente no TE, enquanto o tamanho da família na cultura do milho tem efeito negativo.


Subject(s)
Cost Efficiency Analysis , Agricultural Cultivation , Zea mays , Turkey , Regression Analysis
20.
Rev. cuba. enferm ; 37(4)dic. 2021.
Article in Spanish | LILACS-Express | LILACS, BDENF, CUMED | ID: biblio-1408295

ABSTRACT

Introducción: La procrastinación académica es la conducta negativa de postergar sin razón diversas tareas. Se ha relacionado con diferentes variables, sin embargo, se desconoce si los hábitos de lectura influyen en su reducción. Objetivo: Determinar la influencia de los hábitos de lectura en la procrastinación académica en estudiantes de enfermería. Métodos: Estudio descriptivo, correlacional causal, con una muestra de 271 estudiantes de enfermería de primero a quinto año de formación en la Universidad Nacional de San Agustín de Arequipa, Perú. Se usaron dos instrumentos: el Inventario de hábitos de lectura de Muñoz y la escala de procrastinación de Busko. Se aplicó la prueba r de Pearson y el análisis de regresión lineal. Resultados: Las estudiantes de enfermería tuvieron edades que fluctúan entre los 16 y 25 años, con predominio del sexo femenino. Los hábitos de lectura fueron de nivel medio en el 66,79 por ciento y alto en el 30,99 por ciento de los casos. El 97,05 por ciento de estudiantes tuvo algún nivel de procrastinación, de los cuales 2,58 por ciento registró un nivel alto. Existe asociación significativa tanto entre hábitos de lectura y edad, como entre procrastinación y año de estudios. Conclusión: Los hábitos de lectura se relacionan de forma inversa con la procrastinación académica y predicen su disminución(AU)


Introduction: Academic procrastination is the negative behavior of putting off various tasks without reason. It has been related to different variables; however, it is unknown whether reading habits influence its reduction. Objective: To determine the influence of reading habits on academic procrastination in nursing students. Methods: Descriptive study, causal correlation, with a sample of 271 nursing students from first to fifth year of training at the National University of San Agustín de Arequipa, Peru. Two instruments were used: Muñoz Reading Habits Inventory and Busko Procrastination Scale. Pearson's r test and linear regression analysis were applied. Results: The nursing students had ages that fluctuate between 16 and 25 years, with a predominance of females. Reading habits were medium level in 66.79 percent and high in 30.99 percent of the cases. Certain level of procrastination was identified in 97.05 percent of students, 2.58 percent of them registered a high level. There is significant association between reading habits and age, as well as between procrastination and year of studies. Conclusion: Reading habits are inversely related to academic procrastination and predict its decline(AU)


Subject(s)
Humans , Reading , Students, Nursing , Procrastination , Epidemiology, Descriptive , Regression Analysis
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