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1.
Medwave ; 21(6): e8223, 31-07-2021.
Article in English | LILACS | ID: biblio-1284251

ABSTRACT

Objective This living systematic review aims to provide a timely, rigorous and continuously updated summary of the evidence available on the role of pulmonary rehabilitation in the treatment of patients with COVID-19. Design This is the protocol of a living systematic review. Data sources We will conduct searches in the L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that maps PICO questions to a repository maintained through regular searches in electronic databases, preprint servers, trial registries and other resources relevant to COVID-19. No date or language restrictions will be applied. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the effect of pulmonary rehabilitation as monotherapy or in combination with other interventions-versus sham or no treatment in patients with COVID-19. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will pool the results using meta-analysis and will apply the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assess the certainty of the evidence for each outcome. Ethics and dissemination No ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.


Subject(s)
Humans , COVID-19/rehabilitation , Lung Diseases/rehabilitation , Research Design , Randomized Controlled Trials as Topic , Meta-Analysis as Topic , Databases, Factual , Recovery of Function , Systematic Reviews as Topic , COVID-19/complications , Lung Diseases/virology
2.
Rev. cuba. reumatol ; 23(1): e870, tab
Article in Spanish | LILACS, CUMED | ID: biblio-1280402

ABSTRACT

Introducción: La COVID-19 causa una variada gama de manifestaciones clínicas. En pacientes con enfermedades reumáticas destacan, además de las manifestaciones respiratorias, las manifestaciones articulares, dermatológicas, generales y cardiovasculares. Objetivo: Identificar las manifestaciones cardiovasculares que con mayor frecuencia se presentan en pacientes con enfermedades reumáticas afectados por la COVID-19. Métodos: Se realizó una investigación básica, no experimental, con alcance exploratorio, descriptivo y explicativo de un universo constituido por 37 pacientes con diagnóstico previo de enfermedad reumática y diagnóstico confirmado de COVID-19. Se empleó la observación dirigida y la revisión documental como técnicas de investigación para identificar la presencia de manifestaciones cardiovasculares en este tipo de pacientes. Resultados: Predominaron las pacientes femeninas (59,56 por ciento), con diagnóstico de osteoartritis (72,97 por ciento) y artritis reumatoide (72,97 por ciento) y con comorbilidades asociadas (83,78 por ciento). La hipertensión arterial (61,29 por ciento) y el hipotiroidismo (38,71 por ciento) fueron las comorbilidades más frecuentes. El 70,27 por ciento de los pacientes presentaron manifestaciones cardiovasculares: hipertensión arterial (65,38 por ciento), trastornos del ritmo cardiaco (57,69 por ciento) y el síndrome de Raynaud (53,85 por ciento). El 80,0 por ciento de los pacientes masculinos presentaron manifestaciones cardiovasculares, al igual que el 80,64 por ciento de los casos con enfermedad reumática, COVID-19 y comorbilidades asociadas. Conclusiones: Las manifestaciones cardiovasculares se presentaron con elevada frecuencia en los pacientes reumáticos con diagnóstico de COVID-19, sobre todo pacientes masculinos con comorbilidades asociadas. Las manifestaciones cardiovasculares más frecuentes fueron la hipertensión arterial, los trastornos del ritmo y el síndrome de Raynaud(AU)


Introduction: COVID-19 generates a wide range of clinical manifestations in general. In patients with rheumatic diseases, in addition to respiratory manifestations, joint, dermatological, general and cardiovascular manifestations, among others, stand out. Objective: To identify the cardiovascular manifestations that most frequently occur in patients with rheumatic diseases and COVID-19. Methods: A basic, non-experimental research was carried out, with an exploratory, descriptive and explanatory scope. Universe made up of 37 patients with a previous diagnosis of rheumatic disease and a confirmed diagnosis of COVID-19. Directed observation and documentary review were used as research techniques to identify the presence of cardiovascular manifestations in this type of patient. Results: Predominance of female patients (59.56 percent), diagnosed with osteoarthritis (72.97 percent) and rheumatoid arthritis (72.97 percent) and with associated comorbidities (83.78 percent). Hypertension (61.29 percent) and hypothyroidism (38.71 percent) were the most frequent comorbidities. 70.27 percent of the patients presented cardiovascular manifestations, predominantly arterial hypertension (65.38 percent), rhythm disorders (57.69 percent) and Raynaud´s syndrome (53.85 percent). 80.0 percent of the male patients presented cardiovascular manifestations, as did 80.64 percent of the cases with rheumatic disease, COVID-19 and associated comorbidities. Conclusions: Cardiovascular manifestations occurred with high frequency in rheumatic patients diagnosed with COVID-19; being more frequent in male patients and with associated comorbidities. High blood pressure, rhythm disorders and Raynaud's syndrome were the most frequent(AU)


Subject(s)
Humans , Arthritis, Rheumatoid/complications , Signs and Symptoms , Cardiovascular Diseases/complications , Coronavirus Infections/complications , Early Diagnosis , Research Design
3.
Rev. Círc. Argent. Odontol ; 79(229): 9-17, abr. 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1253242

ABSTRACT

La aparición de aparatología preadjustada ha colaborado en la efectividad de los tratamientos de ortodoncia, pero para que la expresión de esta aparatología se logre, es necesario una correcta colocación de los brackets y la permanencia de estos en boca durante todo el tratamiento. La precisión en la colocación mejora con la técnica de cementado indirecta, ya que permite el acceso a las zonas posteriores, a lugares donde se ve disminuida la visión y además disminuye la condensación de aliento y contaminación salival. Si bien esta técnica requiere tiempo extra de laboratorio, es más rápida en la etapa clínica (AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Silicone Elastomers , Cementation/methods , Orthodontic Brackets , Phosphoric Acids/chemistry , Research Design , Schools, Dental , Acid Etching, Dental/instrumentation , Efficacy , Dental Impression Technique , Dental Bonding/instrumentation , Composite Resins , Dental Models
4.
Edumecentro ; 13(1): 149-166, ene.-mar. 2021. tab
Article in Spanish | LILACS | ID: biblio-1149238

ABSTRACT

RESUMEN Fundamento: la hipertensión arterial es una enfermedad de elevada prevalencia a nivel mundial, a menudo con graves consecuencias para la vida de las personas que la padecen. Objetivo: valorar la efectividad de un programa de intervención educativa para modificar conocimientos sobre estilos de vida saludables en pacientes hipertensos. Métodos: se realizó una investigación acción en el consultorio médico de familia 17-5 del Policlínico Universitario "Chiqui Gómez-Lubián" de Santa Clara, Villa Clara, entre enero-marzo de 2020. Se emplearon métodos teóricos: análisis-síntesis, inducción-deducción e histórico-lógico; empíricos: análisis documental y encuesta en forma de cuestionario a los pacientes antes y después de aplicado el programa; para valorar su efectividad se realizó un análisis estadístico. Resultados: el diagnóstico aplicado demostró que la mayoría de los pacientes tenían desconocimiento sobre su enfermedad y estilos de vida saludables relacionados con los beneficios de sus medicamentos para controlar la hipertensión, la educación nutricional, ingestión de bebidas alcohólicas, el hábito de fumar, el ejercicio físico, el estrés, la obesidad y el consumo de café, por lo que se aplicó una programa de intervención educativa que fue valorado por especialistas. Conclusiones: su efectividad se evidenció porque se modificaron de forma significativa los conocimientos sobre la enfermedad y las prácticas inadecuadas de estilos de vida de los pacientes muestreados.


ABSTRACT Background: hypertension is a highly prevalent disease worldwide, often with serious consequences for the live of people who suffer from it. Objective: to assess the effectiveness of an educational intervention program to modify knowledge about healthy lifestyles in hypertensive patients. Methods: an action research was carried out in the family doctor's office 17-5 of the "Chiqui Gómez-Lubián" University Polyclinic of Santa Clara, Villa Clara, from January toMarch 2020. Theoretical methods were used: analysis-synthesis, induction- deduction and historical-logical; empirical ones: documentary analysis and survey in the form of a questionnaire to patients before and after applying the program; to assess its effectiveness, a statistical analysis was carried out. Results: the applied diagnosis showed that most of the patients had ignorance about their disease and healthy lifestyles related to drug benefits to control hypertension, nutritional education, ingestion of alcoholic beverages, smoking, physical exercises, stress, obesity and coffee intake, for which an educational intervention program was applied that was assessed by specialists. Conclusions: its effectiveness was evidenced because knowledge about the disease and inappropriate lifestyle practices of the sampled patients were significantly modified.


Subject(s)
Research Design , Risk Factors , Health Status Indicators , Health Strategies , Risk Assessment , Education, Medical , Health Promotion
5.
Rev. cuba. med ; 60(1): e1640,
Article in Spanish | LILACS, CUMED | ID: biblio-1156551

ABSTRACT

La pesquisa activa en salud ha sido definida por Fernández Sacasas JA y Díaz Novás J, como el conjunto de acciones diagnósticas que tienden a identificar el estado de salud individual en grupos de población, con la finalidad de establecer los factores de riesgo existentes y descubrir tempranamente la morbilidad oculta, con el objetivo de ser incluidos en programas y de este modo, garantizar su seguimiento y atención continuada.1 Dicho concepto se patentiza en el Sistema Nacional de Salud Cubano, al hacer que la Atención Primaria de Salud sea la base angular del sistema, dándole accesibilidad a los servicios de salud a la totalidad de la población del país. Esto permite dar atención médica continua con un manejo integrador de sus problemas y sus determinantes sociales de salud. Es, por tanto, que en su concepción, desde que en el año 1984 se funda el Programa del Médico y la Enfermera de la Familia, la pesquisa activa que realizan los especialistas de la Medicina General


Subject(s)
Research Design/standards , Coronavirus Infections/epidemiology , Cuba
6.
Rev. baiana saúde pública ; 45(Especial 1): 125-139, 20210101.
Article in Portuguese | LILACS | ID: biblio-1178368

ABSTRACT

A pandemia de Covid-19 impactou a vida dos indivíduos, causando adoecimento, sofrimento psíquico e morte de milhares de pessoas. Propõe-se apresentar, neste artigo, estratégias metodológicas de pesquisa-intervenção com objetivo de rastrear casos de transtorno mental comum (TMC) em trabalhadores(as) no estado da Bahia no contexto da pandemia. Foi realizada revisão bibliográfica para delineamento da proposta de vigilância em saúde a partir dos descritores "transtornos mentais", "Covid-19", "pandemia por Coronavírus e transtorno mental" e "Covid-19", com busca na base Medline e no site Google Acadêmico. Delimitou-se ações em duas dimensões específicas: (1) rastreamento dos casos de TMC a partir dos sistemas de informação e-SUS VE e Sivep-Gripe; articulação com entidades representativas de trabalhadores(as) e rastreamento de tentativas de suicídios e óbitos por causas externas a partir de dados secundários; (2) investigação da relação do transtorno mental com o trabalho e sua consequente notificação em sistema de informação. O rastreamento dos TMC em trabalhadores(as) permitirá conhecer a magnitude do evento na população. O delineamento de projeto piloto como uma estratégia de ação possibilita a identificação de facilitadores e barreiras no processo de implantação, tendo em vista a adequação e/ou ampliação da intervenção para outras regiões do estado, no âmbito da Rede Estadual de Saúde do Trabalhador. A articulação interinstitucional ensino-serviço no desenvolvimento do projeto piloto amplia a capacidade de compreensão e delimitação de respostas da vigilância em saúde à problemática, subsidiando ações individuais e coletivas, de assistência e prevenção dos transtornos mentais na população de trabalhadores(as).


The Covid-19 pandemic affected the peoples' life, causing illness, psychological distress and death. This article presents methodological research-intervention strategies to survey cases of common mental disorder (CMD) in workers of the state of Bahia relating it to the pandemic. A Bibliographic review was conducted to outline the health surveillance proposal based on the descriptors: "transtornos mentais", "Covid-19", "pandemia por Coronavírus e transtorno mental" and Covid-19, with search on the Medline database and Google Scholar website. Actions were delimited in specific dimensions: (1) searching for CMD cases from the e-SUS VE and Sivep-Gripe information systems; articulation with representative bodies of workers and search for suicide attempts and deaths from external causes based on secondary data; (2) investigating of the relationship between mental disorder and work and its consequent notification in an information system. The survey of CMD in workers will allow knowing the magnitude of the event in the population. The design of a pilot project as an action strategy allows the identification of facilitators and barriers in the implementation process considering the adapting and/or expanding needs of the intervention to other regions within the State Workers' Health Network. The interinstitutional teaching-service articulation expands the capacity for understanding and delimiting health surveillance responses, supporting individual and collective actions, assistance and prevention of mental disorders in the worker population.


La pandemia del Covid-19 afectó a la vida de las personas causando enfermedades, angustia psicológica y muerte. En este artículo se propone presentar estrategias metodológicas de investigación-intervención con el objetivo de rastrear casos de trastorno mental común (TMC) en trabajadores del estado de Bahía en el contexto de la pandemia. Se realizó una revisión bibliográfica para perfilar la propuesta de vigilancia de la salud a partir de los descriptores: "trastornos mentales"; "Covid-19"; "Pandemia de coronavirus y trastorno mental" y "Covid-19", con búsqueda en la base de datos Medline y el sitio web de Google Scholar. Las acciones se delimitaron en dos dimensiones específicas: (1) seguimiento de casos de TMC en los sistemas de información e-SUS VE y Sivep-Gripe; articulación con órganos representativos de trabajadores y seguimiento de intentos de suicidio y muertes por causas externas con base en datos secundarios; (2) investigación de la relación entre trastorno mental y trabajo y su consiguiente notificación en un sistema de información. El rastreo de los trastornos mentales en trabajadores permitirá conocer su magnitud en la población. El diseño de un proyecto piloto como estrategia de acción posibilita la identificación de facilitadores y barreras en el proceso de implementación con miras a adaptar y/o expandir la intervención a otras regiones del estado, en la Red Estadual de Salud de los Trabajadores. La articulación interinstitucional docencia-servicio en el desarrollo del proyecto piloto amplía la capacidad para comprender y delimitar las respuestas de vigilancia en salud a la problemática, subsidiando acciones individuales y colectivas, de atención y prevención de trastornos mentales en la población de trabajadores.


Subject(s)
Humans , Male , Female , Mental Health , Public Health Surveillance , COVID-19/psychology , Mental Disorders/epidemiology , Research Design , Brazil/epidemiology , Mass Screening , Occupational Health , Mental Disorders/diagnosis
7.
Article in Chinese | WPRIM | ID: wpr-879199

ABSTRACT

Chinese traditional medicine compound is the main form of Chinese medicine clinical application. The elucidation of the effective components of traditional Chinese medicine is one of the key scientific issues to promote the modernization of traditional Chinese medicine. At present, there are many research ideas on the effective components of traditional Chinese medicine compounds. By analyzing the current status and existing problems of existing research ideas, the author proposes a "double reduction network pharmacology"(2 R network pharmacology) research method based on "prediction of dominant components-potential target selection". Chemical components with good properties were selected by ADMET property prediction technology, and compared with the blood components and target organ components to determine the dominant components with potential therapeutic effect, that is "reducing constituents"; the potential core regulatory pathway of traditional Chinese medicine compound was enriched by RNA-Seq technology combined with network database, and then the target of traditional Chinese medicine compound was mined based on the signal pathway, that is "reducing targets". To improve the efficiency and accuracy of effective component screening, the network relationship of "component target" was established by the related technology of network pharmacology. The purpose of this study is to provide practical research ideas and methods for clarifying the effective components of traditional Chinese medicine, revealing the law of compatibility of traditional Chinese medicine and clarifying the target of drug action.


Subject(s)
Databases, Factual , Drugs, Chinese Herbal/pharmacology , Medicine, Chinese Traditional , Molecular Docking Simulation , Research Design
8.
Article in Chinese | WPRIM | ID: wpr-879143

ABSTRACT

Pharmacology network was used to investigate the common key target and signaling pathway of Notoginseng Radix et Rhizoma in the protection against diabetic nephropathy(DN), diabetic encephalopathy(DE) and diabetic cardiomyopathy(DCM). The chemical components of Notoginseng Radix et Rhizoma were obtained through TCMSP database and literature mining, and SwissTargetPrediction database was used to predict potential targets of Notoginseng Radix et Rhizoma. The disease targets of DN, DE and DCM were obtained through OMIM and GeneCards databases. The overlapped targets of component targets and disease targets of DN, DE and DCM were obtained, and the network of "chemical component-target-disease" was established. The enriched GO and KEGG of the overlapped genes were investigated by using ClueGo plug-in with Cytoscape. At the same time, the PPI network was constructed through STRING database, and the common key targets for the treatment of three diseases by Notoginseng Radix et Rhizoma were obtained through topological parametric mathematical analysis by Cytoscape. A total of 166 chemical components and 835 component targets were screened out from Notoginseng Radix et Rhizoma. Briefly, 216, 194 and 230 disease targets of DN, DE and DCM were collected, respectively. And 54, 45 and 57 overlapped targets were identified when overlapping these disease targets with component targets of Notoginseng Radix et Rhizoma, respectively. Enrichment analysis indicated that the AGE-RAGE signaling pathway and FoxO signaling pathway were the common pathways in the protection of Notoginseng Radix et Rhizoma against DN, DE and DCM. Network analysis of the overlapped targets showed that TNF, STAT3, IL6, VEGFA, MAPK8, CASP3 and SIRT1 were identified as key targets of Notoginseng Radix et Rhizoma against DN, DE and DCM, the selected key targets were verified by literature review, and it was found that TNF, IL6, VEGFA, CASP3 and SIRT1 had been reported in the literature. In addition, there were the most compounds corresponding to the commom core target STAT3, indicating that more compounds in Notoginseng Radix et Rhizoma could regulate STAT3. This study indicated that Notoginseng Radix et Rhizoma potentially protected against DN, DE and DCM through regulating AGE-RAGE signaling pathway and FoxO signaling pathway and 7 common targets including TNF, STAT3, IL6, VEGFA, MAPK8, CASP3 and SIRT1. This study provided a reference for the research of "different diseases with same treatment" and also elucidated the potential mechanism of Notoginseng Radix et Rhizoma against DN, DE and DCM.


Subject(s)
Brain Diseases , Diabetes Mellitus , Diabetic Cardiomyopathies/genetics , Diabetic Nephropathies/genetics , Humans , Research Design , Signal Transduction
9.
Article in Chinese | WPRIM | ID: wpr-879123

ABSTRACT

This paper introduced the basic definition, application scope, advantages and challenges of the master protocol, basket design, umbrella design and platform trial, and put forward the idea of using master protocol, basket design and umbrella design in Chinese medicine(CM) by considering the characteristics of CM and research experiences. The author pointed out that master protocol, basket design and umbrella design, as a high-efficiency research and design strategy, can be used in the clinical research on the treatment of the same disease with different therapies, the treatment of different diseases with the same therapy and the combination of diseases and CM syndromes. In particular, the exploration from the classification of CM syndromes can supplement the gaps in the cli-nical research on CM syndromes. In the application of such designs, it is also necessary to pay attention to their potential challenges and develop reasonable and feasible plans on research implementation, management and statistical analysis in advance to meet these challenges.


Subject(s)
Dietary Supplements , Medicine, Chinese Traditional , Precision Medicine , Records , Research Design
10.
Article in Chinese | WPRIM | ID: wpr-879109

ABSTRACT

The research on endophytes of medicinal plants mainly relies on the traditional culture and isolation methods. Because of their functions such as promoting host growth, improving stress resistance, promoting the accumulation of medicinal active ingredients or directly producing medicinal active ingredients, the endophytes of medicinal plants have gradually attracted wide attention. However, it was found that the strains isolated by traditional methods were not the true dominant endophytes of medicinal plants by comparing the results of traditional culture isolation with high-throughput sequencing. The blind and random nature of traditional methods leads to the lack of standards in terms of medium selection, culture time and interaction between species. On the contrary, high-throughput sequencing technology is an emerging molecular biology technology developed in recent decades. Due to its high resolution level and indepen-dent culture, it can be used for thorough analysis of the community structure and diversity of environmental microorganisms. Therefore, we proposed the strategy of using high-throughput sequencing technology to guide the traditional culture and isolation of endophytes from medicinal plants. Firstly, the endophytic structure and diversity of medicinal plants were completely clear by high-throughput sequencing technology, and the dominant endophytes of the host were unequivocal. Then according to the characteristics of each dominant endophytes design or query suitable medium for its growth to culture and isolation. Finally, the function of the isolates was studied. This method can prevent researchers from missing out on the important functional strains of the host, expand the research scope of endophytes of medicinal plants, and facilitate the in-depth excavation and utilization of endophytes of medicinal plants.


Subject(s)
Endophytes/genetics , High-Throughput Nucleotide Sequencing , Plants, Medicinal , Research Design
11.
Article in Chinese | WPRIM | ID: wpr-879083

ABSTRACT

To sort out the key points in "PICOS" design of clinical trial scheme for influenza, and optimize the clinical trial scheme of Chinese patent medicine in the treatment of influenza by strictly following the principle of evidence-based medicine, focusing on the clinical practice of the disease, and highlighting the characteristics of traditional Chinese medicine. "The design of a randomized, double-blind, positive parallel control study of a certain herbal preparation for the treatment of non-severe influenza" was taken as an example in this study, and the key points in the clinical trial design of Chinese patent medicine for the treatment of influenza were specifically discussed from six aspects, including the type of study, object of study, intervention measures, control measures, outcome indicators and frequently asked questions in test design. From methodological suggestions, in the design scheme of clinical trial on efficacy and safety of Chinese patent medicine in the treatment of influenza, the randomized controlled study should be the first choice for type of study; the inclusion criteria should define both the diagnostic criteria of Western medicine and the syndromes of traditional Chinese medicine(TCM); the exclusion criteria should include a comprehensive list of confounding factors and special circumstances lea-ding to bias in the study results; the interventions should be based on a well-defined dosing programme; internationally recognized positive drugs or guidelines should be used as control measures, with median antipyretic time as the main outcome indicator. For the evalua-tion of curative effect, disease symptom scale can be set, and the TCM syndrome scoring scale was carefully used in this study, with time nodes set for the efficacy evaluation standard. The full name of the drugs should be written in the regulations on combined drug use and prohibited drug use.


Subject(s)
Double-Blind Method , Drugs, Chinese Herbal/therapeutic use , Evidence-Based Medicine , Humans , Influenza, Human/drug therapy , Medicine, Chinese Traditional , Randomized Controlled Trials as Topic , Research Design , Treatment Outcome
12.
Article in Chinese | WPRIM | ID: wpr-879063

ABSTRACT

The research on the historical production areas of Dao-di herbs is of great value to the quality evaluation, production base and protection for geographic indications of Dao-di herbs. Current studies mostly focused on the sorting of written sources, but neglected the excavation of image records such as historical maps and topographic maps. This paper aims at exploreing the geographical scope and evolution mode of historical production area of the Dao-di herbs by combining the method of historical map labelling with the traditional literature and historical research methods. It can be divided into three steps: production area name extraction, historical map labelling and textual research on the historical production area of Dao-di herbs. This method may provide a better way to show the geographical scope and topographic features of the historical production areas of Dao-di herbs through historical maps labelling, which is essential to further explore the evolution of production areas of Dao-di herbs from ancient times to the present by comparing historical maps of different periods, and may be helpful to discover the reasons for the formation and evolution of historical producing areas of Dao-di herbs from different perspectives such as environment, climate, humanities, economy, policy, etc. In addition, the historical map database can be used for map labelling to help establish the relationship between the dynasties, historical names, and change cha-racteristics of the scope of the historical production areas of Dao-di herbs in the following research.


Subject(s)
Drugs, Chinese Herbal , Geography , Medicine, Chinese Traditional , Plants, Medicinal , Research Design
13.
Article in Chinese | WPRIM | ID: wpr-879032

ABSTRACT

The innovation and patent layout of traditional Chinese medicine compounds reflects the innovation level of the traditio-nal Chinese medicine industry to a certain extent. Lianhua Qingwen Formula was taken as an example to analyze the innovation and patent layout of traditional Chinese medicine compounds. The study first proposed an innovative technology system for traditional Chinese medicine compounds, and then analyzed the advantages and disadvantages of Lianhua Qingwen Formula in innovation and patent layout based on 56 patents and other relevant patents. The analysis results showed that Lianhua Qingwen Formula had the following characte-ristics in terms of patent layout. In terms of innovation technical route, the patented technical route of Lianhua Qingwen Formula was mainly based on the composition and preparation of granules as the first choice, followed by corresponding process improvements, new uses, and detection methods as the main improvement routes. In terms of the corresponding patent layout, the basic patent protection scope of Lianhua Qingwen Formula completely covered marketed drugs, and then took new functions as the main layout strategy for subsequent patent applications. With the advancement of modern technical means, the preparation process and testing methods have been optimized continuously. At the same time, the international patent layout was given the priority in domestic patent application. Based on the above characteristics, the study gave suggestions for follow-up innovation and patent work for Lianhua Qingwen Formula, so as to provide enlightenment for other traditional Chinese medicine companies in exploring original innovation of traditional Chinese medicine compounds, improving innovative methods, and enhancing the ability of patent layout of innovative achievements.


Subject(s)
Drugs, Chinese Herbal , Medicine, Chinese Traditional , Research Design , Technology
14.
Article in Chinese | WPRIM | ID: wpr-879002

ABSTRACT

To analyze the study advance of Strychni Semen, a kind of traditional Chinese medicine, this study systematically retrieved the related Chinese literatures about Strychni Semen from CNKI database platforms and the core database of Web of Science, and used bibliometrics and CiteSpace 5.6.R5 software to visually display the authors, research institutions, keywords and other contents. A total of 1 895 Chinese literatures and 1 599 English literatures were included in the study. The analysis of Chinese and English literature authors showed that CAI Bao-chang and CHEN Jun had the most publications on Strychni Semen, and CAI Bao-chang's team was the core research team. According to the analysis of publishing institutions, Nanjing University of Traditional Chinese Medicine and Chinese Academy of Science were the research institutions with the largest number of Chinese and English literatures, respectively. But there was less cooperation between Chinese and English study institutions. The analysis of keywords in Chinese and English literatures showed that the research contents of Strychni Semen mainly focused on component analysis, research methods, receptor targets, clinical application, synergistic and attenuation measures. Break analysis showed that the apoptosis induced by Strychni Semen was a hot research topic, and research on components, toxicity and pharmacokinetics will be the research hotspot in future. The research on Strychni Semen is still in the developing period. This study has provided reference for the rapid grasp of the research contents and the judgment of research hotspots.


Subject(s)
Bibliometrics , Databases, Factual , Medicine, Chinese Traditional , Research Design , Semen
15.
Article in Chinese | WPRIM | ID: wpr-878970

ABSTRACT

Polygonatum cyrtonema is a famous bulk medicinal material which is the medicinal and edible homologous. With the implementation of the traditional Chinese medicine industry to promote precise poverty alleviation, the planting area of P. cyrtonema in Jinzhai is becoming larger and larger in recent years. Jinzhai is located in the Dabie Mountainous area, which is the largest mountain area and county in Anhui Province. The cultivation of P. cyrtonema is scattered, and the traditional Chinese medicine resources investigation is not only inefficient and accurate. In this study,the "Resource 3"(ZY-3) remote sensing image was used as the best observation phase,and the method of support vector machine classification was used. The method of parallelepiped, minimum distance, mahalanob is distance, maximum likelihood classification and neural net were used to classify and recognize the P. cyrtonema in the whole region. In order to determine the accuracy and reliability of classification results, the accuracy of six supervised classification results was evaluated by confusion matrix method, and the advantages and disadvantages of six supervised classification methods for extracting P. cyrtonema field planting area were compared and analyzed. The results showed that the method of support vector machine classification was more appropriate than that using other classification methods. It provides a scientific basis for monitoring the planting area of P. cyrtonemain field.


Subject(s)
Medicine, Chinese Traditional , Polygonatum , Reproducibility of Results , Research Design , Support Vector Machine
16.
Article in Chinese | WPRIM | ID: wpr-877614

ABSTRACT

Pilot study is essential prerequisite for large-scale research. Acupuncture is a complex intervention measure. The factors of its clinical effect and effect mechanism are complicated. Hence, the resource waste is easily induced in research if the large-scale clinical research is rashly carried out before scientific verification. Currently, there is still a lack of high-quality evidence of clinical research, which affects the promotion and application of the curative effect of acupuncture. The pilot study of acupuncture can evaluate the feasibility and the process coordination of trial, optimize program and process and provide the basis of sample size calculation prior to launching a full-scale trial. Thereby, the methodological quality of acupuncture research and the reliability of trial results can be improved. In the paper, the arguments focus on the definition, design and report of pilot study so as to provide the approaches and references for the design and implementation of pilot study of clinical research of acupuncture.


Subject(s)
Acupuncture Therapy , Pilot Projects , Reproducibility of Results , Research Design , Treatment Outcome
17.
Article in Chinese | WPRIM | ID: wpr-877513

ABSTRACT

Field survey is an important foundation for of birth cohort. In a field survey, data such as the environmental exposures, genetics, lifestyle and biological samples will be collected. This document establishes specifications for institutions' establishment, site preparation, coding system, the recruitment of participants, and quality control in the field survey of birth cohort research.


Subject(s)
Cohort Studies , Environmental Exposure , Humans , Quality Control , Research Design
18.
Cad. Saúde Pública (Online) ; 37(9): e00352520, 2021. tab, graf
Article in Portuguese | LILACS | ID: biblio-1339563

ABSTRACT

O objetivo do estudo foi analisar o nível de sedimentação da avaliação de tecnologias em saúde (ATS) hospitalar em diversos contextos. Foi realizada revisão de escopo segundo metodologia do Instituto Joanna Briggs, cujo modelo de análise dos dados foi composto pela combinação das dimensões de estrutura, processo e resultado de Donabedian e das dimensões do projeto Adopting Hospital Based Health Technology Assessment in European Union (AdHopHTA). Foram identificados 270 estudos, após remoção de duplicatas e leitura de textos completos, 36 referências atenderam aos critérios de elegibilidade. Trinta e seis hospitais foram identificados, sendo 24 hospitais de grande porte com capacidade extra de leitos. Vinte e três hospitais tinham vínculos universitários. Destaque ao Canadá, com cinco hospitais universitários, sendo quatro com financiamento público. Metade dos hospitais identificados tinham unidades de ATS hospitalar (18/36). Hospitais com nível sedimentado corresponderam a 75% (27/36) e parcialmente sedimentado a 25% (9/36). Não houve hospital com sedimentação incipiente. Mensurar o nível de sedimentação da ATS nos hospitais identificados contribui para o entendimento de como a inserção ocorre no campo da ATS hospitalar. Neste estudo, mostrou-se a importância de identificar fatores como sustentabilidade, crescimento e evolução da ATS hospitalar em países com e sem tradição com o tema.


El objetivo del estudio fue analizar el nivel de sedimentación en la evaluación de tecnologías de salud (ATS) en hospitales dentro de diversos contextos. Se realizó una revisión de alcance, según la metodología del Instituto Joanna Briggs, cuyo modelo de análisis de datos estuvo compuesto por la combinación de las dimensiones: estructura, proceso y resultado de Donabedian, así como las dimensiones del proyecto Adopting Hospital Based Health Technology Assessment in European Union (AdHopHTA). Se identificaron 270 estudios, tras la eliminación de duplicados y lectura de textos completos, 36 referencias atendieron a los criterios de elegibilidad. Se identificaron treinta y seis hospitales, 24 de los cuales, de gran porte, con capacidad extra de camas. Veintitrés hospitales contaban con vínculos universitarios. Canadá merece una mención especial, con cinco hospitales universitarios, cuatro de los cuales con financiación pública. La mitad de los hospitales identificados tenían unidades de ATS hospitalaria (18/36). Hospitales con un nivel sedimentado correspondieron a un 75% (27/36), y parcialmente sedimentado a un 25% (9/36). No hubo hospital con sedimentación incipiente. Medir el nivel de sedimentación de la ATS en los hospitales identificados contribuye al entendimiento de cómo se produce la inserción en el campo de la ATS hospitalaria. En este estudio, se mostró la importancia de identificar factores como: sostenibilidad, crecimiento y evolución de la ATS hospitalaria en países con y sin tradición en este ámbito.


The aim of this study was to analyze the level of sedimentation of hospital-based health technology assessment (HTA) in diverse contexts. A scoping review was conducted according to the methodology of the Joanna Briggs Institute, whose data analysis model consisted of the combination of Donabedian's structure, process, and outcome categories and the dimensions of the project Adopting Hospital Based Health Technology Assessment in European Union (AdHopHTA). We identified 270 studies, and after removing duplicates and reading full texts, 36 references met the eligibility criteria. Thirty-six hospitals were identified, of which there were 24 large-scale hospitals with extra bed capacity. Twenty-three hospitals were affiliated with universities. Canada stood out with five university hospitals, four of which with public funding. Half of the identified hospitals had hospital-based HTA units (18/36). Hospitals with sedimented levels of HTA corresponded to 75% of the sample (27/36), and the remainder had partially sedimented HTA, or 25% of the hospitals in the review (9/36). There were no hospitals with incipient sedimentation. Measuring the level of HTA sedimentation in the hospitals contributed to understanding how their participation has occurred in the field of hospital-based HTA. This study revealed the importance of identifying factors such as sustainability, growth, and evolution of hospital-based HTA in countries with and without a tradition in this field.


Subject(s)
Humans , Research Design , Technology Assessment, Biomedical , Brazil , Canada , Hospitals, University
19.
Rev. bras. educ. méd ; 45(2): e067, 2021. tab
Article in Portuguese | LILACS | ID: biblio-1288291

ABSTRACT

Resumo: Introdução: O crescimento socioeconômico de um país acontece por meio do desenvolvimento de ciência e tecnologia, e, por isso, a parceria com o terceiro setor é positiva ao auxiliar o financiamento de projetos científicos. Objetivos: Assim, o presente estudo objetiva avaliar as formas de captação de recursos mais utilizadas pelos docentes de Medicina para a execução de seus estudos científicos e verificar se há o reconhecimento do terceiro setor como opção para tal obtenção. Métodos: Trata-se de um estudo transversal analítico com abordagem quali-quantitativa, construído por meio do uso de um formulário individual aplicado aos docentes do curso médico de cinco instituições do ensino superior do Norte/Nordeste do Brasil. Os dados obtidos foram analisados por estatísticas descritiva e analítica. Resultados: Participaram 138 professores, de ambos os sexos, com idade média ± 43,2 anos. A pesquisa mais comumente desenvolvida pelos docentes foi a básica (56,1%); 68,8% utilizaram recursos próprios para o desenvolvimento de seus estudos; 18,8% obtiveram recursos de entidades de apoio à pesquisa; 75,4% conheciam alguma fundação de amparo à pesquisa, e as mais citadas foram a Fapespa (26,9%) e o CNPq (26,9%); 13,8% relataram conhecer sites e empresas multinacionais que fomentam projetos de pesquisas, mas somente 2,2% submeteram sua iniciativa às chamadas públicas em instituições internacionais para captação; quando perguntados sobre o terceiro setor, seus fundamentos e atores definidos pela legislação, o estudo apontou uma falta de conhecimento, com 100% de inadequação nas respostas sobre tais entidades; quanto à parceria entre o terceiro setor e o Estado, 83,3% sinalizaram desconhecimento;100% dos entrevistados desconhecem os critérios para uma entidade integrar tal setor, ao mesmo tempo que 76,8% afirmaram que a falta de orientação dos conceitos do ramo não é entrave para a captação de recursos às pesquisas. Conclusão: A maioria dos docentes utilizava recursos próprios para a realização de seus projetos, seguidos pelo uso de recursos públicos. Ademais, grande parte dos profissionais não reconheceu o terceiro setor como fonte patrocinadora, carecendo de informações que lhes possibilitassem desenvolver atividades de forma ampla e com as diversas oportunidades existentes, oferecidas por entidades desse setor.


Abstract: Introduction: The socio-economic growth of a country is reflected by the development of science and technology. Partnership with the third sector is therefore positive in terms of financial support for scientific projects. Objective: Accordingly, the present study aims to evaluate the most commonly used methods of fundraising by medical professors to conduct their scientific studies and whether there is recognition of the third sector as an option for such fundraising. Method: A cross-sectional analytical study with a qualitative and quantitative approach. The data were collected using an individual form, applied to medical course professors from five different universities in the north of Brazil, and analyzed using descriptive-analytical statistics. Results: The study included 138 professors, of both sexes, with an average age of ± 43.2 years. The type of research most commonly performed by professors was basic (56.1%); 68.8% used their own resources to develop their studies; 18.8% obtained funds from research support entities; 75.4% knew of a research support foundation, primarily FAPESPA (26.9%) and CNPQ (26.9%); 13.8% reported knowledge of websites and multinational companies that promote research projects, but only 2.2% submitted their initiative to public calls for funding from international institutions; when asked about the third sector, its fundamentals and actors defined by legislation, the study indicated a lack of knowledge, with 100% of inadequate answers about such entities; regarding partnership between the third sector and the State, 83.3% signaled ignorance; 100% of the interviewees were unaware of the criteria for an entity to be part of the sector, while 76.8% stated that lack of orientation about the concepts of the area is not an obstacle to raising funds for research. Conclusion: Most professors use their own funds to carry out their projects, followed by the use of public funds. Furthermore, most professionals did not recognize the third sector as a source of sponsorship, lacking information that would allow them to develop broad activities and enjoy the various opportunities offered by entities in this sector.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Research Design/statistics & numerical data , Organizations , Research Financing , Fund Raising , Cross-Sectional Studies , Faculty, Medical
20.
Article in Spanish | LILACS, COLNAL | ID: biblio-1152200

ABSTRACT

La universidad es la ventana al conocimiento, pasar por ahí significa enfrentar diversos obstáculos y generar aprendizajes que quedan para toda la vida. Dentro del campus hay muchas oportunidades van surgiendo según el camino que toma cada estudiante, para así poder tener un punto de vista diferente. En ese sentido, la investigación es eso, ver más allá de lo que rodea a la malla académica, es el aumento de la responsabilidad y una decisión que puede cambiar la vida. Para los estudiantes del área de la salud puede resultar difícil el manejo de tal combinación, ya que se requiere de entrega, al igual que en las asignaturas y las prácticas. Por ello, es necesario encontrar estrategias que permitan el aumento de la participación de los estudiantes para promover la investigación y de esta manera contribuir a la producción de literatura científica.


The university is the window to knowledge, passing through it means facing various obstacles and generating learning that remains for life. Within the campus there are many opportunities that are emerging according to the path that each student takes, so that they can have a different point of view. In that sense, research is that, to see beyond what surrounds the academic mesh, is the increase of responsibility and a decision that can change life. For students in the area of health it can be difficult to manage such a combination, as it requires delivery, as well as in subjects and practices. Therefore, it is necessary to find strategies that allow the increased participation of students to promote research and thus contribute to the production of scientific literature.


Subject(s)
Humans , Students, Health Occupations , Research Promotion , Research Design , Community Participation , Knowledge , Scientific Publication Indicators
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