Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 1.089
Filter
1.
Rev. latinoam. enferm. (Online) ; 29: e3397, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1150012

ABSTRACT

Objective: to describe scientific evidence regarding the use of prone positioning in the care provided to patients with acute respiratory failure caused by COVID-19. Method: this is a scoping review. PRISMA Extension for Scoping Reviews was used to support the writing of this study. The search was conducted in seven databases and resulted in 2,441 studies, 12 of which compose the sample. Descriptive statistics, such as relative and absolute frequencies, was used to analyze data. Results: prone positioning was mainly adopted in Intensive Care Units, lasted from a minimum of 12 up to 16 hours, and its prescription was based on specific criteria, such as PaO2/FiO2 ratio, oxygen saturation, and respiratory rate. The most prevalent complications were: accidental extubation, pressure ulcer, and facial edema. Decreased hypoxemia and mortality rates were the main outcomes reported. Conclusion: positive outcomes outweighed complications. Various cycles of prone positioning are needed, which may cause potential work overload for the health staff. Therefore, an appropriate number of trained workers is necessary, in addition to specific institutional protocols to ensure patient safety in this context.


Objetivo: descrever as evidências científicas acerca da utilização da posição prona na assistência ao paciente com insuficiência respiratória aguda provocada por COVID-19. Método: trata-se de uma scoping review. O instrumento PRISMA Extension for Scoping Reviews foi utilizado para a redação do estudo. As buscas foram realizadas em sete bases de dados, resultando em 2.441 estudos dos quais 12 compõem a amostra. Uma análise descritiva dos dados foi realizada empregando frequências relativas e absolutas. Resultados: a utilização da posição prona ocorreu principalmente em Unidades de Terapia Intensiva, com duração mínima de 12 a 16 horas, e teve como fundamentos de indicação critérios específicos, tais como a relação PaO2/FiO2, a saturação de oxigênio e a frequência respiratória. As complicações mais prevalentes da sua utilização foram: extubação acidental, lesão por pressão e edema facial. Identificou-se a redução da hipoxemia e da mortalidade como principais desfechos evidenciados na amostra. Conclusão: os desfechos positivos sobressaíram-se face às complicações. São necessários vários ciclos de pronação do paciente, fator causador de possível sobrecarga de trabalho da equipe de saúde. Portanto, são importantes um adequado dimensionamento dos profissionais, uma equipe treinada e protocolos institucionais específicos a fim de se garantir a segurança do paciente nesse contexto.


Objetivo: describir las evidencias científicas acerca de la utilización de la posición prona en la atención al paciente con insuficiencia respiratoria aguda provocada por COVID-19. Método: se trata de una revisión de escopo. El instrumento PRISMA Extension for Scoping Reviews fue utilizado para la redacción del estudio. Las búsquedas fueron realizadas en siete bases de datos, resultando en 2.441 estudios de los cuales 12 integran la muestra. Un análisis descriptivo de los datos fue desarrollado empleando frecuencias relativas y absolutas. Resultados: la utilización de la posición prona ocurrió principalmente en Unidades de Terapia Intensiva, con duración mínima de 12 a 16 horas, y tuvo como fundamentos de indicación criterios específicos, tales como la relación PaO2/FiO2, la saturación de oxígeno y la frecuencia respiratoria. Las complicaciones más frecuentes de su uso fueron: desintubación accidental, lesión por presión y edema facial. Se identificó la reducción de la hipoxemia y de la mortalidad como principales resultados evidenciados en la muestra. Conclusión: los resultados positivos se destacaran ante las complicaciones. Son necesarios varios ciclos de pronación del paciente, factor causante de una posible sobrecarga de trabajo del equipo de salud. Por lo tanto, son importantes un adecuado dimensionamiento de los profesionales, un equipo capacitado y protocolos institucionales específicos a fin de garantizar la seguridad del paciente en ese contexto.


Subject(s)
Patient Care Team , Respiratory Distress Syndrome , Respiratory Insufficiency , Respiratory Tract Infections , Prone Position , Coronavirus Infections , Pressure Ulcer , Edema , Alkalies , Equipment and Supplies , Airway Extubation , Critical Care Nursing , Intensive Care Units , Hypoxia
2.
MedUNAB ; 24(1): 92-99, 23-04-2021.
Article in Spanish | LILACS | ID: biblio-1222780

ABSTRACT

Introducción. La pandemia del SARS-CoV-2 se empezó a reportar desde diciembre de 2019 en la localidad de Wuhan, China, luego se presentaron miles de casos en el mundo. Dentro de las medidas adoptadas a nivel mundial en todos los aspectos, se encuentra el distanciamiento social, lo que ha conllevado al cierre de distintos sectores de la economía; entre ellos la educación superior. La educación médica sufre un cambio repentino al suspender las clases presenciales y los campos de práctica; de este modo, se tuvo que afrontar distintos cambios e innovaciones en sus procesos educativos. El objetivo de este trabajo es realizar una revisión sobre las modalidades implementadas y reportadas en la literatura mundial durante la pandemia en las facultades de medicina. Temas a tratar. Educación médica durante pandemia, facultades de medicina, educación virtual, medidas de educación médica durante tiempos de pandemia, experiencias en educación médica previas a la pandemia, educación a distancia y presencialidad asistida por tecnología, plataformas digitales en el proceso de enseñanza, situación futura e interrogantes. Conclusiones. La implementación de la tecnología en la educación médica de una manera única permitirá a los estudiantes desarrollar habilidades de colaboración y mejorar la adaptabilidad. Es todo un reto la educación médica frente a la pandemia de SARS-CoV-2. Cómo citar: Zuluaga-Gómez M.Valencia-Ortiz NL. Educación en facultades de medicina del mundo durante el periodo de contingencia por SARS-COV-2. MedUNAB. 2021;24(1): 92-99. doi: https://doi.org/10.29375/01237047.3942


Introduction. The SARS-CoV-2 pandemic started being reported in December 2019 in the locality of Wuhan, China. Subsequently, thousands of cases arose around the world. Among the measures adopted worldwide in all aspects is social distancing, which has led to closure of various sectors of the economy, among which is higher education. Medical education experienced a sudden change when on-site classes and fields of practice were suspended. In this way, people had to face different changes and innovations in their educational processes. The objective of this study is to review the implemented and reported modalities in the global literature of faculties of medicine during the pandemic. Areas to be Addressed. Medical education during the pandemic, faculties of medicine, virtual education, medical education measures during the pandemic, experiences in medical education prior to the pandemic, e-learning and on-site education assisted by technology, digital platforms in the teaching process, future situations and questions. Conclusions. Uniquely implementing technology in medical education will allow students to develop collaborative skills and improve their adaptability. This is a challenge to medical education during the SARS-CoV-2 pandemic. Cómo citar: Zuluaga-Gómez M.Valencia-Ortiz NL. Educación en facultades de medicina del mundo durante el periodo de contingencia por SARS-COV-2. MedUNAB. 2021;24(1): 92-99. doi: https://doi.org/10.29375/01237047.3942


Introdução. A pandemia SARS-CoV-2 começou a ser relatada em dezembro de 2019 na cidade de Wuhan, China, depois milhares de casos foram notificados em todo o mundo. Entre as medidas adotadas mundialmente em todos os aspectos, está o distanciamento social, que tem levado ao fechamento de diversos setores da economia, entre eles, o ensino superior. Aeducação médica sofreu uma mudança repentina com a suspensão de aulas presenciais e dos campos de prática; dessa forma, diferentes mudanças e inovações tiveram de ser enfrentadas em seus processos educacionais. O objetivo deste trabalho é realizar uma revisão sobre as modalidades implementadas e relatadas na literatura mundial durante a pandemia nas faculdades de medicina. Tópicos a abordar. Educação médica durante a pandemia, faculdades de medicina, educação virtual, medidas de educação médica em tempos de pandemia, experiências na educação médica antes da pandemia, educação a distância e educação presencial assistida por tecnologia, plataformas digitais no processo de ensino, situação futura e questões. Conclusões. A implementação da tecnologia na educação médica de uma maneira única permitirá que os alunos desenvolvam habilidades colaborativas e melhorem a adaptabilidade. A educação médica face à pandemia da SARS-CoV-2 é um grande desafio. Cómo citar: Zuluaga-Gómez M.Valencia-Ortiz NL. Educación en facultades de medicina del mundo durante el periodo de contingencia por SARS-COV-2. MedUNAB. 2021;24(1): 92-99. doi: https://doi.org/10.29375/01237047.3942


Subject(s)
Education, Medical , Respiratory Distress Syndrome , Schools, Medical , Coronavirus Infections , Education, Distance , Education, Higher , Pandemics
3.
Rev. cuba. pediatr ; 92(4): e973, oct.-dic. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1144518

ABSTRACT

Introducción: El síndrome de dificultad respiratoria aguda es una enfermedad que cursa con hipoxemia severa, poco frecuente en las unidades de cuidados intensivos pediátricos, pero con elevada mortalidad. Objetivo: Determinar la relación entre variables demográficas y clínicas con la duración de la ventilación mecánica y la supervivencia en niños con síndrome de dificultad respiratoria aguda. Métodos: Estudio retrospectivo de los pacientes ingresados en 15 unidades de cuidados intensivos pediátricos, con diagnóstico de síndrome de dificultad respiratoria aguda. Se evaluaron variables demográficas, las formas clínicas del síndrome de dificultad respiratoria aguda, duración de la ventilación mecánica y la supervivencia. Las variables cualitativas se expresaron en valores absolutos y porcentajes, las variables cuantitativas se analizaron con la prueba ji-cuadrada de Pearson y comparación de medias. Resultados: Se registraron 282 pacientes, de ellos 63,7 por ciento menores de seis años, el 54,4 por ciento del sexo masculino y el 51,1 por ciento de piel blanca. Las formas clínicas pulmonares prevalecieron (58,1 por ciento) y se correlacionaron (p= 0,022) con la supervivencia, la mediana de la duración de la ventilación mecánica fue de 10 días. Existió relación (p= 0,000) entre la duración de la ventilación y la mortalidad. Se registró una mortalidad global de 40,78 por ciento, (n= 115). Conclusiones: El síndrome de dificultad respiratoria aguda tiene mayor incidencia en los menores de seis años y en las formas clínicas pulmonares que se relacionan con una mayor supervivencia, la cual se eleva en la medida que aumentan los días de ventilación mecánica(AU)


ABSTRACT Introduction: The acute respiratory distress syndrome is a disease that evolves with severe hypoxemia, and it is not frequent in pediatric intensive care units, but it has high mortality rates. Objective: To determine the relation between demographic and clinical variables with the mechanical ventilation and survival in children with acute respiratory distress syndrome. Methods: Retrospective study in patients admitted in 15 pediatric intensive care units with diagnosis of acute respiratory distress syndrome. There was an assessment of the demographic variables, the clinical forms of this syndrome, the duration of mechanical ventilation and the survival rates. Qualitative variables were presented in absolute values and percentages, and were analyzed with the Pearson´s ji-square test and means comparison. Results: 282 patients were recorded, 63.7 percent of them were under 6 years old, 54.4 percent were males and 51.1 percent were white. Pulmonary clinical forms prevailed (58,1 percent) and were correlated (p= 0,022) with the survival rates, and the mean of mechanical ventilation´s duration was of 10 days. There was relation (p= 0,000) between the duration of ventilation and mortality. It was recorded a total mortality of 40.78 percent (n= 115). Conclusions: Acute respiratory distress syndrome has higher incidence in children under 6 years and in the pulmonary clinical forms that are related with a higher survival, which increases in the same way that mechanical ventilation´s amount of days do(AU)


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Respiration, Artificial/mortality , Respiratory Distress Syndrome/epidemiology , Intensive Care Units, Pediatric , Child Health , Survival Analysis , Retrospective Studies
4.
Acta bioquím. clín. latinoam ; 54(3): 293-307, set. 2020. graf, tab
Article in Spanish | LILACS | ID: biblio-1130604

ABSTRACT

La enfermedad por coronavirus 2019 o COVID-19 que causa neumonía viral y que puede llegar al síndrome de distrés respiratorio agudo, falla multiorgánica y muerte generó un problema de salud de gran relevancia a nivel mundial. Este nuevo agente etiológico de reciente aparición, ha ocasionado desconcierto en los equipos de salud. La heterogeneidad de la presentación clínica del COVID-19 genera nuevos desafíos para la medicina de laboratorio. Hasta el momento se han informado múltiples hallazgos bioquímicos que cambian según las características clínicas del individuo infectado. Los informes de casos son diversos y varían según el lugar y los datos recopilados. En este contexto es necesario poder relacionar dichos sucesos con el desarrollo y curso de la enfermedad. La injerencia del laboratorio no está restringida únicamente al diagnóstico etiológico inicial. Los parámetros bioquímicos juegan un rol fundamental tanto en el monitoreo como en la estadificación y en el pronóstico de la enfermedad. El objetivo de la presente revisión fue abordar las principales alteraciones de parámetros de laboratorio relacionadas a la infección por SARS-CoV-2.


Coronavirus 2019 or COVID-19, a disease which causes viral pneumonia and can reach acute respiratory distress syndrome, multi-organ failure and death, has generated a major health problem, with worldwide relevance. This new etiological agent of recent appearance has caused great confusion among health teams. The heterogeneity of the clinical presentation of COVID-19 brings about new challenges for laboratory medicine. So far, various biochemical findings have been reported, varying according to the infected individual's clinical characteristics as well as to the location and data collected. In this context, it is necessary to be able to relate these events to the development and course of the disease. The role of the laboratory is not restricted only to the initial etiological diagnosis; biochemical parameters play a fundamental role in monitoring and both staging and prognosis of the disease. The objective of this review is to provide an overview of the main laboratory parameter alterations related to SARS-CoV-2 infection.


A doença por coronavírus 2019 ou COVID-19, que causa pneumonia viral podendo chegar à síndrome de angústia respiratória, falha de múltiplos órgãos e morte, provocou um problema de saúde de grande relevância em nível mundial. Esse novo agente etiológico de recente aparecimento causou grande perplexidade nas equipes de saúde. A heterogeneidade da apresentação clínica do COVID-19 cria novos desafios para a medicina laboratorial. Até agora foram relatadas várias descobertas bioquímicas que variam de acordo com as características clínicas da pessoa infectada. Os relatórios dos casos são diversos e variam de acordo ao lugar e dados coletados. Nesse contexto é necessário poder relacionar esses fatos com o desenvolvimento e andamento da doença. O papel do laboratório não é restrito apenas ao diagnóstico etiológico inicial. Os parâmetros bioquímicos desempenham um papel fundamental tanto no monitoramento quanto no estadiamento e prognóstico da doença. O objetivo da presente revisão foi abordar as principais alterações de parâmetros laboratoriais relacionadas com a infecção por SARS-CoV-2.


Subject(s)
Play and Playthings , Pneumonia, Viral , Prognosis , Respiratory Distress Syndrome , Role , Syndrome , Coronavirus Infections , Coronavirus , Geological Fault , Equipment and Supplies , Reference Parameters , Betacoronavirus/pathogenicity , Infections , Patient Care Team , Patients , Disease , Causality , Confusion , Monitoring , Death , Growth and Development , Diagnosis , Research Report , Betacoronavirus , Embarrassment , Laboratories
6.
Lima; IETSI; 17 jun. 2020. ilus.
Non-conventional in Spanish | LILACS, BRISA | ID: biblio-1100102

ABSTRACT

INTRODUCCIÓN: La actual pandemia de COVID-19 esta presentando un grave problema de salud pública, debido a su impacto tanto en la salud como en la economía de los ciudadanos. Si bien esta enfermedad se puede presentar de manera leve o inclusive asintomática, aproximadamente el 17% de los pacientes pueden llegar a presentar edema pulmonar, falla multiorgánica, y síndrome de distrés respiratorio agudo (SDRA), lo que amerita una suplementación de oxigeno invasiva. El síndrome de distrés respiratorio agudo se define a traves de los criterios de Berlin, la cual aborda dimensiones como el tiempo, imagen de tórax, origen del edema, y la oxigenación. Se ha registrado que el 10% de los pacientes que ingresan a UCI pueden presentar SDRA, puediendo ser producido por sepsis y neumonía, con una mortalidad que varía entre el 30% y 40. Debido a la alta mortalidad en los pacientes que desarrollan SDRA, se ha evaluado la posibilidad de complementar el tratamiento estándar, basado en una ventilación mecánica a presión positiva, con otras forma posible para poder mejorar la oxigenación y sobrevivencia de los pacientes, en este caso surge la ventilación prona como una medida de bajo costo probablemente efectiva. La ventiación prona se basa en colocar al paciente en decúbito prono para mejorar el reclutamiento de las regiones dorsales pulmonares, aumentar el volumen final espiratorio, aumentar la expansión de la pared torácica, disminuir el shunt alveolar, y mejorar el volumen tidal. Ante la necesidad de establecer estrategias efectivas para mejorar la supervivencia en los pacientes COVID-19 que desarrollan SDRA, se realiza la presente síntesis rápida de evidencia sobre los artículos publicados que evalúen la efectividad y seguridad de la ventilación prona en los pacientes de SDRA, por cualquier etiología, y por COVID 19. MÉTODOS: Criterios de Elegibilidad: Criterios de Inclusion: Relacionados con el tema a tratar: Ventilación Prona en Síndrome de Distrés Respiratorio Agudo y/o COVID-19. En población Adulta. Tipos de estudio: Revisiones sistemáticas con o sin meta-análisis, y estudios observacionales. Idioma: Aquellos publicados en inglés, español. Publicados en los últimos 5 años. Criterios de Exclusion: Tipo de estudio: cartas al director, editoriales, comentarios, fichas técnicas e informes breves. RESULTADOS: Busqueda Bibliografica: Para la PICO 1 se identificó 56 revisiones sistemáticas (RS) publicadas como artículos científicos, de los cuales se excluyeron 27 mediante título y abstract por no abordar los criterios de la pregunta PICO, quedando un total de 29 RS. De estas se excluyeron 23, debido a que tuvieron un fecha de búsqueda de estudios mayor de 5 años, incluyéndose sólo 6 RS. Para la PICO 2 inicialmente se realizó una búsqueda de revisiones sistemáticas, dentro de la cual no se identificó algún estudio que repondiera a la pregunta planteada, por lo que se procedió a realizar la búsqueda de estudios primarios. En ella se identificaron 39 estudios primarios, de los cuales se excluyeron 32 mediante título y abstract, por no abordar los criterios de la pregunta PICO, quedando un total de 6 estudios. De estos se excluyeron 4 debido a que no hacían las comparaciones entre la intevención y comparador o correspondían a un reporte de caso. Finalmente se incluyó sólo 2 estudios observacionales para la síntensis de evidencia. Evaluacion de Calidad: Se realizó una evaluación de la calidad de las revisiones sitemáticas utilizando la herramienta AMSTAR-2. De las 6 evaluadas, 1 tuvo una confianza alta, 3 moderada, y 2 tuvieron confianza baja o criticamente baja. Así mismo, la evaluación de los estudios no experimentales se realizó mediante el instrumento ROBINS-I, donde se evidenció un alto riesgo de sesgo para ambos estudios incluídos. Estudios que Evaluan Pacientes con Sdra y uso de Ventilación Prona: Para la PICO 1 se incluyeron seis revisiones sistemáticas, de las cuales sólo se selecionaron dos para la síntesis de evidencia, debido a que realizaban un análisis más complejo que abordaba la comparación de la ventilación prona con todas las estrategias ventilatorias. Se seleccionaron la RS con network meta-analisis de Wang 2016 (5) y Aoyama 2019. CONCLUSIONE: Pacientes con Sdra y uso de Ventilación Prona: El uso de la ventilación prona en SDRA tiene una base científica bastante grande, la cual se ha venido desarrollando y actualizando con el tiempo, que sugieren beneficios en aspectos de mortalidad frente a otras terapias ventilarias o en combinaciones. Se concluye que la ventilación prona disminuye la mortalidad a los 28 días efectividad cuando se compara con VMO ECMO y LPV en pacientes con SDRA moderado a severo y SDRA severo, respectivamente (evita 170 y 124 muertes más en 1000 pacientes, respectivamente). Así mismo, al combinar estrategias, la LVT+FiO2-HPEEP más la posición prona es considerada como una posible estrategias de ventilación óptima para pacientes con SDRA. No existe diferencias estadísticamente signficativas entre el uso de ventilación prona y otras estrategias de ventilación en cuanto a la seguridad para el riesgo de barotrauma en pacientes con SDRA. Los estudios seleccionados no han abordado otros outcomes de seguridad como las úlceras por presión y las movilizaciones del tubo orotraqueal, las cuales son las complicaciones más frecuentes reportadas en los pacientes que utilizan ventilación prona. Sólo un estudio ha diferenciado según la severidad del SDRA, incluyendo pacientes con SDRA de severidad moderada a severa y severa. Sin embargo, en ambos casos tuvieron una mayor proporción estudios con pacientes con SDRA severo. Por lo que es necesario la realización de futuros estudios que aborden o que hagan distinción de los resultados según subgrupos de severidad. Pacientes con Covid-19 y uso de Ventilación Prona: No se han encontrado ensayos clínicos aleatorizados que aborden la efectividad el uso de ventilación prona en pacientes COVID-19. Se han identificado dos estudios primarios tipo series de casos que han evaluado los cambios en la saturación de oxígeno, PaO2/FiO2, y compliance pulmonar antes y posterior al uso ventilación de prona. Los estudios incluidos presentan algunas limitaciones como que no han abordado outcomes de seguridad (como eventos adversos, etc.), presentan un alto riesgo de sesgo general, y sólo han includio muestras pequeñas de pacientes (<100 participantes). Así mismo, no han realizado un análisis estadístico ajustado por confusores. Ambos estudios sólo han reportado sus resultados descriptivamente, y en un caso se ha realizado una prueba de hipótesis. Con la evidencia disponible no es posible determinar la eficacia ni la seguridad del uso de la ventilación prona en pacientes con COVID-19.


Subject(s)
Humans , Respiration, Artificial/methods , Respiratory Distress Syndrome/therapy , Coronavirus Infections/therapy , Technology Assessment, Biomedical , Health Evaluation
7.
Rev. Hosp. Ital. B. Aires (2004) ; 40(2): 53-55, jun. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1102484

ABSTRACT

Una de las características de la afección pulmonar por enfermedad por coronavirus (COVID-19) es la disociación entre la gravedad de la hipoxemia y el mantenimiento de una mecánica respiratoria relativamente conservada. En este contexto se ha establecido una teoría en relación con dos fenotipos de pacientes con síndrome de distrés respiratorio del adulto (SDRA): un fenotipo Low, caracterizado por baja elastancia y baja reclutabilidad, y un fenotipo High, con características de alta elastancia y alta reclutabilidad. Presentamos el caso de un paciente que cursó internación en la Unidad de Terapia Intensiva de Adultos de nuestro hospital, con clínica, mecánica ventilatoria y patrón tomográfico compatible con el fenotipo Low de SDRA por COVID-19. (AU)


Dissociation between severity of hypoxemia and relative preserved respiratory mechanics is a characteristic observed in lung impairment due to coronavirus disease (COVID-19). Patients with COVID-19 that present adult respiratory distress syndrome (ARDS) are identified for one of two phenotypes according to a theory recently established. The Low phenotype is distinguished by low elastance and low recruitability; and the High phenotype, by high elastance and high recruitability. The case describes a patient admitted in the adult Intensive Care Unit of Hospital Italiano de Buenos Aires with observed symptoms, ventilatory mechanics and tomographic pattern that are compatible with Low phenotype of ARDS due to COVID-19. (AU)


Subject(s)
Humans , Male , Middle Aged , Respiratory Distress Syndrome/microbiology , Coronavirus Infections/therapy , Phenotype , Respiratory Distress Syndrome/genetics , Respiratory Mechanics , Coronavirus Infections/diagnosis , Coronavirus Infections/physiopathology , Cough/etiology , Dyspnea/etiology , Fever/etiology , Hypertension/complications , Intensive Care Units , Hypoxia/physiopathology , Obesity/complications
8.
ABCS health sci ; 45: [1-6], 02 jun 2020. tab
Article in English | LILACS | ID: biblio-1097558

ABSTRACT

INTRODUCTION: Pregnancy-related diseases have aggravated the situation of postpartum women, who end up using Mechanical Ventilation (MV) when admitted to Intensive Care Units (ICU). Although MV has benefits, it is associated with deleterious effects that can be minimized with the use of Electrical Impedance Tomography (EIT). OBJECTIVE: The aim was to analyze the epidemiological profile and ventilatory parameters of mothers, which developed HELLP Syndrome, sepsis and/or Acute Respiratory Distress Syndrome (ARDS), under MV and monitored with EIT. METHODS: The study was observational, cross-sectional, retrospective and prospective conducted between March and September 2018, using data collection forms filled from the database and sociodemographic, obstetric and ventilatory records of postpartum women admitted to adult ICU. RESULTS: The sample consisted of 13 postpartum women, 8 with sepsis (61.5%), 7 with HELLP syndrome (53.8%) and 4 with ARDS (30.8%). Five patients (38.5%) evolved with more than one of these conditions. Regarding the ventilatory parameters evaluated, VT 378.9 (±103.9) mL were observed and mean values found for PEEP 9.8 (±1.9) cmH2O and driving pressure 11.1 (±1.4) cmH2O are below recommendations in the literature, predicting lower mortality and morbidity index. CONCLUSION: The relevance of the driving pressure assessment in the MV setting was demonstrated, a parameter assessed by the EIT and directly related to static lung compliance (Cstat), PEEP, VT and optimization of regional pulmonary ventilation. It is highlighted the need for future research with greater clinical significance regarding the profile of postpartum women about the increasingly frequent diseases in this population.


INTRODUÇÃO: As doenças relacionadas à gravidez tem agravado o quadro de puérperas, que acabam fazendo uso de Ventilação Mecânica (VM) quando internadas em Unidades de Terapia Intensiva (UTI). A VM, apesar de trazer benefícios, está associada a efeitos deletérios que podem ser minimizados com o uso da Tomografia por Impedância Elétrica (TIE). OBJETIVO: Analisar o perfil epidemiológico e parâmetros ventilatórios de puérperas que evoluíram com Síndrome HELLP, Sepse e/ou Síndrome do Desconforto Respiratório Agudo (SDRA), sob VM e monitoradas com a TIE. MÉTODOS: Estudo observacional, transversal retrospectivo e prospectivo, realizado entre março e setembro de 2018, por meio de fichas de coletas preenchidas a partir de banco de dados/prontuários sociodemográficos, obstétricos e ventilatórios de puérperas internadas em UTI. RESULTADOS: Amostra composta por 13 puérperas, oito com Sepse (61,5%), sete com Síndrome HELLP (53,8%) e quatro com SDRA (30,8%), demonstrando que cinco (38,5%) pacientes evoluíram com mais de uma dessas patologias. Acerca dos parâmetros ventilatórios avaliados, observou-se VT 378.9 (± 103.9) e que valores médios encontrados para PEEP 9.8 (±1.9) e driving pressure 11.1 (±1.4) estão abaixo dos preconizados pela literatura, predizendo menores índices de mortalidade e morbidade. CONCLUSÃO: Demonstrou-se relevância da avaliação de driving pressure no cenário da VM, parâmetro avaliado por meio da TIE e diretamente relacionado à Cst, PEEP, VT e otimização da ventilação pulmonar regional. Destaca-se a necessidade de pesquisas futuras que apresentem maiores significâncias clínicas voltadas ao perfil de puérperas em relação às doenças cada vez mais frequentes nesta população.


Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications, Infectious , Respiratory Distress Syndrome , HELLP Syndrome , Postpartum Period , Respiration, Artificial , Health Profile , Electric Impedance , Intensive Care Units
10.
Medellín; Unidad de Evidencia y Deliberación para la Toma de Decisiones UNED. Facultad de Medicina, Universidad de Antioquia; 20200000. 57 p.
Monography in Spanish | PIE, LILACS, PIE | ID: biblio-1095463

ABSTRACT

Los hallazgos de esta síntesis rápida están organizados de tal manera que responden las 4 preguntas planteadas. Cada subsección presenta los hallazgos relevantes de las revisiones sistemáticas, y los resultados del metaanálisis realizado con 20 estudios observacionales específicos para COVID-19 no incluidos en las revisiones sistemáticas. Los factores clínicos y paraclínicos considerados en el metaanálisis de efectos aleatorios fueron la edad, comorbilidades como la hipertensión arterial, diabetes mellitus, enfermedad cardiovascular, malignidad, y enfermedad renal crónica; y los paraclínicos dímero D, proteína C reactiva (PCR), interleuquina 6 (IL-6), procalcitonina, deshidrogenasa láctica (LDH), y recuento linfocitario.


Subject(s)
Humans , Mortality , Respiratory Distress Syndrome , Coronavirus Infections , Delivery of Health Care , Multiple Organ Failure
11.
Autops. Case Rep ; 10(3): e2020194, 2020. graf
Article in English | LILACS | ID: biblio-1131834

ABSTRACT

We report on a 3-month old infant male who had a seven-days history of fever and rhinorrhea associated with wheezing prior to his death, during the Covid-19 pandemic. Viral testing for Covid-19 (SARS-CoV-2) was negative but was positive for Coronavirus 229E and RP Human Rhinovirus. The pulmonary histological examination showed diffuse alveolar damage along with thrombotic microangiopathy affecting alveolar capillaries. Also, thrombotic microangiopathy was evident in the heart, lungs, brain, kidneys and liver. Thrombotic microangiopathy is a major pathologic finding in Acute Respiratory Distress Syndrome and in the multiorgan failure. This is the first report that illustrates thrombotic microangiopathy occurring in lung, heart, liver, kidney and brain in Acute Respiratory Distress Syndrome with Coronavirus 229E with Rhinovirus co-infection. The clinical presentation and pathological findings in our case share common features with Covid-19.


Subject(s)
Humans , Male , Infant , Respiratory Distress Syndrome , Rhinovirus , Coronavirus Infections/complications , SARS Virus , Thrombotic Microangiopathies/complications , Autopsy , Fatal Outcome , Coinfection , Multiple Organ Failure
12.
Guatemala; MSPAS; [2020?]. 78 p. graf.
Non-conventional in Spanish | LILACS, LIGCSA | ID: biblio-1151708

ABSTRACT

Elaborados por MSPAS y asociaciones de médicos especialistas en mayo del 2020 y actualizados en julio del mismo año, estos protocolos pretenden orientar a los profesionales a cargo de la atención de pacientes moderados y críticos con COVID-19. Esta seccionado en una parte general, que incluye los síntomas de las condiciones de alto riesgo, flujogramas y detalles de lo que puede presentarse, así como la sección de adultos, niños y mujeres embarazadas. El estudio afirma que, "el 14% acaba presentando un cuadro grave que requiere hospitalización y oxigenoterapia, y el 5% tiene que ser ingresado en una unidad de cuidados intensivos" Incluye flujogramas de Factores de Riesgo en Paciente Adulto y Mujer Embarazada por categorías, así como notas, comentarios y recomendaciones de los médicos participantes.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Infant , Child, Preschool , Child , Adult , Aged , Pneumonia, Viral/diagnosis , Respiratory Insufficiency/complications , Shock/complications , Shock/drug therapy , Oxygenation/methods , Coronavirus Infections/diagnosis , Coronavirus Infections/drug therapy , Pediatrics/organization & administration , Pneumonia, Viral/drug therapy , Pregnancy Complications/prevention & control , Respiratory Distress Syndrome , Respiratory Insufficiency/drug therapy , Coronavirus Infections/mortality , Pandemics/prevention & control , Betacoronavirus , Guatemala , Intensive Care Units , Intubation
14.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-827023

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
16.
Rev Assoc Med Bras (1992) ; 66(4): 498-501, 2020. graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1136239

ABSTRACT

SUMMARY The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic shows a rapid increase in cases and deaths. The World Health Organization (WHO) has shown that more than 200.000 confirmed cases have been identified in more than 166 countries/territories. Public health authorities in Brasil have reported 532 confirmed cases by March 19. Approximately 5% of the patients will require intensive care unit treatment with oxygen therapy and mechanical ventilation. Limited data are available about rehabilitation protocols for severe illness and intensive care treatment of COVID-19 increase. Thus, we aim to show current information about COVID-19, describing symptoms and the respiratory management for critical patients and preventive care. Physical therapists and all health care professionals need to recognize the challenges they will face in the coming months.


RESUMO O surgimento da pandemia do Coronavírus 2019 (COVID-19) tem demonstrado rápido aumento dos casos e das mortes. A Organização Mundial da Saúde (OMS) apontou que mais de 200.000 casos confirmados foram identificados em mais de 166 países/territórios. As autoridades de saúde pública no Brasil relataram 532 casos confirmados até 19 de março. Aproximadamente 5% dos pacientes necessitarão de tratamento em unidade de terapia intensiva com oxigenoterapia e ventilação mecânica. Temos disponíveis dados limitados sobre protocolos de reabilitação para doenças graves e tratamento em unidade de terapia intensiva de pacientes com COVID-19. Assim, nosso objetivo é mostrar informações atuais sobre o COVID-19, descrevendo sintomas e controle respiratório de pacientes críticos e cuidados preventivos. Fisioterapeutas e todos os profissionais de saúde precisam reconhecer os desafios que enfrentaremos nos próximos meses.


Subject(s)
Humans , Pneumonia, Viral/therapy , Physical Therapy Modalities/standards , Coronavirus Infections/therapy , Physical Therapists/standards , Betacoronavirus , Pneumonia, Viral/physiopathology , Pneumonia, Viral/prevention & control , Respiratory Distress Syndrome/therapy , Respiratory Therapy/standards , Brazil , Practice Guidelines as Topic/standards , Coronavirus Infections , Coronavirus Infections/physiopathology , Coronavirus Infections/prevention & control , Critical Care/standards , Pandemics/prevention & control
17.
Rev. Soc. Bras. Med. Trop ; 53: e20190481, 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1136849

ABSTRACT

Abstract INTRODUCTION: Patients with acute respiratory failure due to influenza require ventilatory support. However, mechanical ventilation itself can exacerbate lung damage and increase mortality. METHODS: The aim of this study was to describe a feasible and protective ventilation protocol, with limitation of the tidal volume to ≤6 mL/kg of the predicted weight and a driving pressure ≤15 cmH2O after application of the alveolar recruitment maneuver and PEEP titration. RESULTS: Initial improvement in oxygenation and respiratory mechanics were observed in the four cases submitted to the proposed protocol. CONCLUSIONS: Our results indicate that the mechanical ventilation strategy applied could be optimized.


Subject(s)
Humans , Male , Female , Aged , Respiratory Distress Syndrome , Influenza, Human , Respiration, Artificial , Tidal Volume , Positive-Pressure Respiration , Middle Aged
18.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-828750

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
19.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-828586

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
20.
Chinese Medical Journal ; (24): 1390-1396, 2020.
Article in English | WPRIM | ID: wpr-827665

ABSTRACT

BACKGROUND@#Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and those receiving maximal medical support, have been noted to progress to irreversible fatal respiratory failure. Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.@*METHODS@#From February 10 to March 10, 2020, three male patients were urgently assessed and listed for transplantation. After conducting a full ethical review and after obtaining assent from the family of the patients, we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.@*RESULTS@#Two of the three recipients survived post-LT and started participating in a rehabilitation program. Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved. The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. Government health affair systems, virology detection tools, and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.@*CONCLUSIONS@#LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis. If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT, LT provided the final option for these patients to avoid certain death, with proper protection of transplant surgeons and medical staffs. By ensuring instant seamless care for both patients and medical teams, the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained.


Subject(s)
Aged , Betacoronavirus , Coronavirus Infections , Mortality , Extracorporeal Membrane Oxygenation , Humans , Lung Transplantation , Methods , Male , Middle Aged , Pandemics , Pneumonia, Viral , Mortality , Pulmonary Fibrosis , Mortality , General Surgery , Respiratory Distress Syndrome , Mortality , General Surgery
SELECTION OF CITATIONS
SEARCH DETAIL