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1.
Article in English | WPRIM (Western Pacific) | ID: wprim-762182

ABSTRACT

PURPOSE: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study. METHODS: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed. RESULTS: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74). CONCLUSIONS: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.


Subject(s)
Allergens , Analgesics , Animals , Antipyretics , Asian Continental Ancestry Group , Asthma , Bronchial Hyperreactivity , Cats , Child , Classification , Cohort Studies , Comorbidity , Dermatophagoides pteronyssinus , Disease Management , Humans , Methacholine Chloride , Odds Ratio , Ownership , Parturition , Phenotype , Prevalence , Rhinitis, Allergic , Risk Factors , Skin
2.
Article in English | WPRIM (Western Pacific) | ID: wprim-762179

ABSTRACT

PURPOSE: We evaluated the severity of olfactory disturbance (OD) in the murine model of allergic rhinitis (AR) and local allergic rhinitis (LAR) in mice. We also investigated the therapeutic effect of an intranasal steroid on OD. METHODS: Forty BALB/c mice were divided into 5 groups (n = 8 for each). The control group was sensitized intraperitoneally (i.p.) and challenged intranasally (i.n.) with saline. Mice in the AR group got i.p. and i.n. ovalbumin (OVA) administration for AR induction. The LAR group was challenged i.n. with 1% OVA for inducing local nasal allergic inflammation, without inducing the systemic allergy. The OD group got an i.p. methimazole administration (75 mg/kg) to induce total destruction of olfactory mucosa. Mice in the intranasal budesonide group received i.n. budesonide (12.8 μg per time, 30 minutes after the i.n. OVA challenge) while using OVA to cause systemic allergies. We conducted a buried-food pellet test to functionally assess the degree of OD in each group by measuring the time taken until finding hidden food. We evaluated the damage to olfactory epithelium using histopathologic evaluation and compared the degree of olfactory marker protein (OMP) expression in olfactory epithelium using immunofluorescent staining. RESULTS: Mice of the AR (81.3 ± 19.8 seconds) and LAR groups (66.2 ± 12.7 seconds) spent significantly more time to detect the pellets than the control group (35.6 ± 12.2 seconds, P < 0.01). After treatment, the intranasal budesonide group exhibited significantly better results (35.8 ± 11.9 seconds) compared with the AR and LAR groups (P < 0.01). The AR and LAR groups showed considerable olfactory epithelial damage and suppression of OMP expression compared with the control group. In the intranasal budesonide group, the olfactory lesions and OMP expression had improved substantially. CONCLUSIONS: OD may be caused by olfactory epithelial damage and suppression of OMP expression in nasal allergic inflammation and could be reversed using an intranasal steroid.


Subject(s)
Animals , Budesonide , Hypersensitivity , Inflammation , Methimazole , Mice , Olfaction Disorders , Olfactory Marker Protein , Olfactory Mucosa , Ovalbumin , Ovum , Quality of Life , Rhinitis, Allergic , Steroids
3.
Article in English | WPRIM (Western Pacific) | ID: wprim-762176

ABSTRACT

PURPOSE: Oak is the dominant tree species in Korea. Oak pollen has the highest sensitivity rate among all allergenic tree species in Korea. A deep neural network (DNN)-based estimation model was developed to determine the concentration of oak pollen and overcome the shortcomings of conventional regression models. METHODS: The DNN model proposed in this study utilized weather factors as the input and provided pollen concentrations as the output. Weather and pollen concentration data were used from 2007 to 2016 obtained from the Korea Meteorological Administration pollen observation network. Because it is difficult to prevent over-fitting and underestimation by using a DNN model alone, we developed a bootstrap aggregating-type ensemble model. Each of the 30 ensemble members was trained with random sampling at a fixed rate according to the pollen risk grade. To verify the effectiveness of the proposed model, we compared its performance with those of models of regression and support vector regression (SVR) under the same conditions, with respect to the prediction of pollen concentrations, risk levels, and season length. RESULTS: The mean absolute percentage error in the estimated pollen concentrations was 11.18%, 10.37%, and 5.04% for the regression, SVR and DNN models, respectively. The start of the pollen season was estimated to be 20, 22, and 6 days earlier than that predicted by the regression, SVR and DNN models, respectively. Similarly, the end of the pollen season was estimated to be 33, 20, and 9 days later that predicted by the regression, SVR and DNN models, respectively. CONCLUSIONS: Overall, the DNN model performed better than the other models. However, the prediction of peak pollen concentrations needs improvement. Improved observation quality with optimization of the DNN model will resolve this issue.


Subject(s)
Korea , Pollen , Quercus , Rhinitis, Allergic , Rhinitis, Allergic, Seasonal , Seasons , Trees , Weather
4.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-811453

ABSTRACT

Research on physical activity and health is actively being conducted. In the Korea National Health and Nutrition Examination Survey (KNHANES), the Global Physical Activity Questionnaire (GPAQ) was newly introduced in 2014. The purpose of this study was to investigate the levels of physical activity and related factors in Koreans who were assessed through the GPAQ by dividing the physical activity by occupation, leisure, and transport domain. This study used data from the KNHANES (2014–2016), the study population of which included 17,357 participants aged 12 to 80 years. We compared the differences in physical activity by sociodemographic factors, health-related factors, and psychological health-related factors. Moreover, we also compared the mean metabolic equivalent of task and daily sitting time according to physical activity domain by sex and age group. Finally, we investigated the sociodemographic factors, health-related factors, and psychological health-related factors that significantly affect the average physical activity per week. The various factors were found to differ in the frequency of physical activity levels. In addition, there was a difference in the amount of physical activity per occupation, leisure, and transport domain in each age group. Finally, age, sex, high-density lipoprotein cholesterol levels, arthritis, allergic rhinitis and sinusitis, sleeping time, and perceived health status significantly affected physical activity. The levels of physical activity significantly differed by sociodemographic factors, health-related factors, and psychological health-related factors. There was also a difference in the physical activity levels according to the age and sex per each domain of physical activity.


Subject(s)
Arthritis , Cholesterol , Humans , Korea , Leisure Activities , Lipoproteins , Metabolic Equivalent , Motor Activity , Nutrition Surveys , Occupations , Physical Fitness , Public Health , Rhinitis, Allergic , Risk Factors , Sinusitis , Social Determinants of Health , Surveys and Questionnaires
5.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-811292

ABSTRACT

E-cigarettes (ECs) and heated tobacco products (HTPs) have become popular in Korea; hence, it is important to determine whether ECs and HTPs are less hazardous than combustible cigarettes (CCs). In general, the levels of harmful and potentially harmful constituents (HPHCs) are lower in ECs and HTPs than in CCs, although the levels of some heavy metals and HPHCs are higher in ECs and HTPs than in CCs. ECs and HTPs showed possible adverse effects on respiratory and cardiovascular system function, which could result in chronic respiratory and cardiovascular system diseases in animals. An analysis of biomarkers showed that ECs had possible adverse health effects on the respiratory and cardiovascular systems, in addition the effects of HTP on respiratory and cardiovascular systems were not significantly different than those of CC. Epidemiological studies identified positive associations between EC use and asthma, chronic obstructive pulmonary disease, and myocardial infarction. Only one epidemiologic study reported a positive association between ever using HTPs and asthma, allergic rhinitis, and atopic dermatitis among adolescents. Modelling studies of ECs did not show consistent findings regarding the health effects compared with those of CCs. A modeling study of HTPs, performed by tobacco industry, has been criticized for many unfounded assumptions. Lower levels of HPHCs in ECs and HTPs, compared with those in CCs, cannot be directly translated into health benefits because the relationship between exposure and effects is non-linear for cardiovascular diseases and because the duration of exposure is more important than the level of exposure in determining lung cancer mortality. In summary, there is no definite health benefit in using ECs or HTPs instead of CCs, for the individual or the population; hence, tobacco control measures should be the same for ECs, HTPs, and CCs. ECs and HTPs have become popular in Korea; hence, it is important to determine whether ECs and HTPs are less hazardous than CCs.


Subject(s)
Adolescent , Animals , Asthma , Biomarkers , Cardiovascular Diseases , Cardiovascular System , Dermatitis, Atopic , Electronic Nicotine Delivery Systems , Epidemiologic Studies , Hot Temperature , Humans , Insurance Benefits , Korea , Lung Neoplasms , Metals, Heavy , Mortality , Myocardial Infarction , Pulmonary Disease, Chronic Obstructive , Rhinitis, Allergic , Smoking , Tobacco Industry , Tobacco Products , Tobacco
6.
Article in English | WPRIM (Western Pacific) | ID: wprim-782277

ABSTRACT

BACKGROUND: Although many epidemiological studies have reported the inverse associations between greenness and health outcomes, inconsistent associations in allergic diseases remain an issue. We aimed to identify associations between greenness and allergic diseases among Korean adults.METHODS: In total, 219,298 adults from the 2009 Korea Community Health Survey were included in this study. Individuals' allergy-related conditions, such as atopic dermatitis and allergic rhinitis, were evaluated. To identify the amount of green areas (m²) per capita in each administrative region, we used the 2009 data for green areas from the Korean Statistical Information Service.RESULTS: The risk for atopic dermatitis in the highest quartile of green areas was significantly lower compared with that of the lowest quartile. Physician's diagnosis and current treatment of odds ratios (ORs) with 95% confidence intervals (CIs) were 0.82 (0.73–0.91) and 0.77 (0.64–0.92), respectively. Similarly, the association results for allergic rhinitis showed that the highest level of green areas was significantly associated with a decreased risk of allergic rhinitis in full-adjustment model quartiles. Physician's diagnosis and current treatment of OR (95% CI) were 0.94 (0.89–0.99) and 0.91 (0.82–1.00), respectively.CONCLUSIONS: We observed inverse associations of green areas with atopic dermatitis and allergic rhinitis in Korean adults.


Subject(s)
Adult , Cross-Sectional Studies , Dermatitis, Atopic , Diagnosis , Epidemiologic Studies , Health Surveys , Humans , Immune System , Information Services , Korea , Odds Ratio , Parks, Recreational , Rhinitis, Allergic
7.
Annals of Dermatology ; : 38-46, 2020.
Article in English | WPRIM (Western Pacific) | ID: wprim-782142

ABSTRACT

BACKGROUND: Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited.OBJECTIVE: This study evaluated the natural history of CU and identified predictors for remission.METHODS: Total 329 Korean patients with CU, who had follow-ups more than 6 months after diagnosis during a 7-year period in the department of dermatology in three university hospitals were enrolled. Clinical data and laboratory findings obtained by medical records and telephone interviews were analyzed, retrospectively.RESULTS: The proportion recovered in 1, 3, and 5 years after the onset of CU was 10.8%, 18.8%, and 32.9%, respectively. The mean duration of CU was 6.3 years. There were no significant differences in median recovery time depending on sex, age group, severity of CU, and type of CU. The presence of angioedema was significantly related to CU severity. There were no differences in prognosis with respect to the presence of dermographism or angioedema. Patients with atopic dermatitis (AD) had a significantly worse prognosis than patients without a history of AD; but not in patients with the history of allergic rhinitis or asthma. Patients with abnormal laboratory findings did not differ significantly in prognosis.CONCLUSION: CU remission rate significantly differ according to the presence of AD. This study provides information about the natural course of CU of Korean patients.


Subject(s)
Angioedema , Asthma , Dermatitis, Atopic , Dermatology , Diagnosis , Epidemiology , Follow-Up Studies , Hospitals, University , Humans , Interviews as Topic , Korea , Medical Records , Natural History , Prognosis , Remission, Spontaneous , Retrospective Studies , Rhinitis, Allergic , Urticaria
8.
Article in English | WPRIM (Western Pacific) | ID: wprim-811104

ABSTRACT

BACKGROUND: Rhinitis was the most frequently diagnosed disorder among users of humidifier disinfectants (HDs). The aim of our study was to investigate on the relationship between allergic rhinitis (AR) and HD uses.METHODS: Our study used the data from the eighth Panel Study on Korean Children; a total of 1,540 participants were enrolled. The χ² test and multiple logistic regression analyses were conducted to debunk the association between AR and HD uses.RESULTS: In our analysis, odds ratios (ORs) of doctor-diagnosed AR increased significantly when simply the response of whether HDs were used in the past was considered. When the brands of HD were considered, ORs of doctor-diagnosed AR were found to be increased significantly for those who have used polyhexamethylene guanidine phosphate/oligo(2-[2-ethoxy]-ethoxyethyl)guanidinium-containing HDs (model 3: 1.41, 95% confidence interval [CI]: 1.02–1.95). However, once duration of usage was additionally considered, ORs of doctor-diagnosed AR increased significantly only for those who have used chloromethylisothiazolinone/methylisothiazolinone-containing HDs for more than or equal to 3 months (model 3: 2.08, 95% CI: 1.17–3.69). Further, past use of HD was associated with significantly increased ORs of AR diagnosed before 2013 (model 3: 1.35, 95% CI: 1.02–1.79).CONCLUSIONS: Results of our study suggest that past uses of HDs may be associated with an increased risk of AR.


Subject(s)
Child , Cross-Sectional Studies , Disinfectants , Guanidine , Humans , Humidifiers , Logistic Models , Odds Ratio , Rhinitis , Rhinitis, Allergic
9.
Asia Pacific Allergy ; (4): 6-2020.
Article in English | WPRIM (Western Pacific) | ID: wprim-785459

ABSTRACT

BACKGROUND: The prevalence of peanut allergy (PA) among children has increased significantly over the past decade. Even though the prevalence of PA in Singapore is considered low, peanut is the top trigger for food-induced anaphylaxis in Singaporean children.OBJECTIVE: To describe the demographic characteristics and clinical features of children with PA.METHODS: This is a 5-year retrospective review of children diagnosed with PA based on clinical history coupled with a positive skin prick test to peanut or positive oral food challenge results.RESULTS: There were 269 patients (53.9% males) with a clinical diagnosis of PA. The median age at first allergic presentation for the PA group was 24 months old, with interquartile range of 13–39 months. The most common form of peanut introduced was roasted peanut. The rate of peanut anaphylaxis was 7.1%. Concomitant tree nut sensitization was found in 32.3% of this cohort, predominantly to cashew nut. Majority of them have a personal history of atopy – 75.8% with eczema, 63.6% with allergic rhinitis, and 19.7% with asthma.CONCLUSION: This is the first large review of peanut-allergic children in Singapore. Prospective population-based studies are needed to establish the true prevalence and risk factors associated with the development of this potentially life-threatening condition.


Subject(s)
Anacardium , Anaphylaxis , Arachis , Asia , Asthma , Child , Cohort Studies , Diagnosis , Eczema , Humans , Nuts , Peanut Hypersensitivity , Prevalence , Prospective Studies , Retrospective Studies , Rhinitis, Allergic , Risk Factors , Singapore , Skin , Trees
10.
Asia Pacific Allergy ; (4): 7-2020.
Article in English | WPRIM (Western Pacific) | ID: wprim-785458

ABSTRACT

BACKGROUND: The incidence of asthma exacerbation (AE) and the predictive value of spirometry and fractional exhaled nitric oxide (FeNO) in school children have not been evaluated.OBJECTIVE: We sought to evaluate the efficacy of spirometry measurement and FeNO monitoring for predicting AE in school children in the Cheongju area in Korea.METHODS: With parental agreement, we studied 170 students aged 7–12 years. Children were evaluated by an asthma specialist using baseline spirometry, skin prick test, seasonal FeNO measurement, and asthma control test. The study participants underwent a physical examination and their medical history was also evaluated by the specialist. They were assessed for asthma control status during regular doctor visits for 1 year.RESULTS: In total, 160 children (94.1%) completed follow-up and FeNO monitoring. Of which, 26 children (16.3%) had AE. AE was associated with male children and children with allergic rhinitis (p < 0.05). While, children with AE tended to have higher FeNO than those without AE, no significant difference was found. The maximum value of FeNO ≥35 ppb was associated with AE (p < 0.05). Children with AE had a significantly decreased baseline forced expiratory volume in 1 second/forced vital capacity (FEV₁/FVC), %predicted, forced expiratory flow at 25%–75% of FVC (FEF(25%–75%)). FEV₁/FVC < 80% was associated with AE in children regardless of inhalant allergen sensitization (all p < 0.05).CONCLUSION: Baseline spirometry had a predictive value of AE in school children. Sensitive spirometric parameters such as FEV₁/FVC and FEF(25%–75%) can be used as prognostic factors to predict future childhood AE. FeNO value ≥ 35 ppb during monitoring was associated with AE in school children.


Subject(s)
Asthma , Child , Follow-Up Studies , Forced Expiratory Volume , Humans , Incidence , Korea , Male , Nitric Oxide , Parents , Physical Examination , Rhinitis, Allergic , Seasons , Skin , Specialization , Spirometry , Vital Capacity
11.
Asia Pacific Allergy ; (4): 11-2020.
Article in English | WPRIM (Western Pacific) | ID: wprim-785454

ABSTRACT

Air pollution, climate change, and reduced biodiversity are major threats to human health with detrimental effects on a variety of chronic noncommunicable diseases in particular respiratory and cardiovascular diseases. The extent of air pollution both outdoor and indoor air pollution and climate change including global warming is increasing-to alarming proportions particularly in the developing world especially rapidly industrializing countries worldwide. In recent years, Asia has experienced rapid economic growth and a deteriorating environment and increase in allergic diseases to epidemic proportions. Air pollutant levels in many Asian countries especially in China and India are substantially higher than are those in developed countries. Moreover, industrial, traffic-related, and household biomass combustion, indoor pollutants from chemicals and tobacco are major sources of air pollutants, with increasing burden on respiratory allergies. Here we highlight the major components of outdoor and indoor air pollutants and their impacts on respiratory allergies associated with asthma and allergic rhinitis in the Asia-Pacific region. With Asia-Pacific comprising more than half of the world's population there is an urgent need to increase public awareness, highlight targets for interventions, public advocacy and a call to action to policy makers to implement policy changes towards reducing air pollution with interventions at a population-based level.


Subject(s)
Administrative Personnel , Air Pollutants , Air Pollution , Air Pollution, Indoor , Allergy and Immunology , Asia , Asian Continental Ancestry Group , Asthma , Biodiversity , Biomass , Cardiovascular Diseases , China , Climate Change , Climate , Consumer Advocacy , Developed Countries , Economic Development , Family Characteristics , Global Warming , Humans , Hypersensitivity , India , Rhinitis, Allergic , Tobacco
12.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-785352

ABSTRACT

PURPOSE: Allergic rhinitis is the most common atopic disease and the most common chronic disease of children. Eosinophil count and percentage in nasal smear are useful for differential diagnosis of allergic rhinitis. The aim of this study is to investigate the correlation between nasal eosinophil count and percentage.METHODS: Between January 2017 and August 2018, 221 children patients with a clinical history of rhinitis were tested at the outpatient respiratory and allergy unit of the Department of Pediatrics, School of Medicine, The Catholic University of Korea. Nasal secretion was collected by swabbing a children's nasal inferior turbinate 3–4 times with a cotton swab and then placed on to a glass slide. Later, the smear was stained by Giemsa stain.RESULTS: This is the first study to assess the comparison of nasal eosinophil count and percent. There is a positive correlation between nasal eosinophil count and percent Y=1.02 X+2.82 (Y=Eosinophil count, X=Eosinophil percentage). To determine the usefulness of nasal eosinophil count and percentage in the diagnosis of allergic rhinitis, we analyzed receiver operating characteristic curves. The cutoff value of the nasal eosinophil count was 6.5/high-power field, and that of the nasal eosinophil ratio was 3% for the diagnosis of allergic rhinitis.CONCLUSION: In patients with suspected rhinitis, one of the values of nasal eosinophil count or percentage can be used in clinical practice.


Subject(s)
Azure Stains , Child , Chronic Disease , Diagnosis , Diagnosis, Differential , Eosinophils , Glass , Humans , Hypersensitivity , Korea , Outpatients , Pediatrics , Rhinitis , Rhinitis, Allergic , ROC Curve , Turbinates
13.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-785351

ABSTRACT

PURPOSE: Recently, the prevalence of allergic rhinitis (AR) in Korean children has been increased. The aim of this study was to investigate the clinical characteristics of rhinitis and to compare clinical parameters between AR and nonallergic rhinitis (NAR) in children.METHODS: We retrospectively reviewed the medical records of 1,034 children under 18 years of age who visited Korea University Anam Hospital for rhinitis symptoms from January 2008 to December 2017. Clinical data, including clinical features, comorbidities, blood test results, allergen sensitization profile, and pulmonary function test parameters, were collected.RESULTS: Among the 1,034 children with rhinitis, 737 (71.3%) were AR and 297 (28.7%) were NAR. The prevalence of AR gradually increased with age. The median levels of eosinophil count (4.1%), serum total IgE (204.4 IU/L), eosinophil cationic protein (ECP) concentration (17.9 µg/L), and fractional exhaled nitric oxide (FeNO) (22.0 ppb) were significantly higher in children with AR than in those with NAR. The sensitization rate to the inhalant allergens increased with age; however, food allergen sensitization rate tended to decrease. Median levels of eosinophil count, total IgE, ECP, and FeNO were significantly higher in the poly-sensitized group than in the mono-sensitized and nonsensitized groups.CONCLUSION: More than 70% of Korean children who have rhinitis symptoms are AR. Children with AR more likely to have higher levels of FeNO and bronchial asthma. Poly-sensitized children showed increased rates of atopic dermatitis and bronchial asthma.


Subject(s)
Allergens , Asthma , Child , Comorbidity , Dermatitis, Atopic , Eosinophil Cationic Protein , Eosinophils , Hematologic Tests , Humans , Immunoglobulin E , Korea , Medical Records , Nitric Oxide , Prevalence , Respiratory Function Tests , Retrospective Studies , Rhinitis , Rhinitis, Allergic
14.
Article in English | WPRIM (Western Pacific) | ID: wprim-785335

ABSTRACT

Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that primary nasal epithelial cells from allergic and non-allergic individuals showed comparable barrier function and secretion of cytokines.


Subject(s)
Cytokines , Epithelial Cells , Humans , Immunoglobulin E , Rhinitis, Allergic
15.
Vaccimonitor (La Habana, Print) ; 28(3)sept.-dic. 2019. tab
Article in Spanish | LILACS (Americas), CUMED | ID: biblio-1094631

ABSTRACT

Los ácaros Dermatophagoides pteronyssinus (Dp), Dermatophagoides siboney (Ds) y Blomia tropicalis (Bt), constituyen la herramienta fundamental para diagnóstico e inmunoterapia de rinitis alérgica (RA), que en muchas ocasiones se asocia al síndrome apnea-hipopnea obstructiva del sueño (SAHOS). Para diagnosticar SAHOS se seleccionaron 465 individuos del registro de alergia del Policlínico Previsora, Camagüey, Cuba, con diagnóstico presuntivo de RA. Se descartaron aquellos con prueba cutánea Prick test negativa a Dp, Ds y Bt y sin poligrafía cardio-respiratoria (PCR), quedando para estudio 236 pacientes entre 8 y 70 años de edad: 102 casos (43,2 por ciento) definidos como aquellos con respiración oral y ronquidos y 134 controles (56,7 por ciento) sin respiración oral ni ronquidos. La PCR se realizó utilizando el marcaje automático de eventos del dispositivo ApneaLink AirTM (Resmed Corp., RFA). La media del tamaño del habón fue de 5,9 mm en los casos (p=0,02). El índice de apnea e hipopnea (IAH) fue positivo en 129 pacientes (54,6 por ciento); de ellos, 97 casos (41,1 por ciento) y 32 controles (13,5 por ciento). Los pacientes con IAH˃20/h predominaron en los casos con 21 individuos (8,8 por ciento) (p꞊0,048). La sensibilidad del PCR fue del 95,10 por ciento, su especificidad del 76,12 por ciento. Los valores predictivos positivos y negativos del 75,19 por ciento y 95,33 por ciento respectivamente. Se estimó en 3,98 la razón de verosimilitud positiva y de 0,06 la negativa. Los pacientes con SAHOS en los casos y controles presentan incremento con predominio para casos (p=0,002). La PCR con el dispositivo ApneaLink permite hacer el diagnóstico de SAHOS en RA(AU)


The mites Dermatophagoides pteronyssinus (Dp), Dermatophagoides siboney (Ds) and Blomia tropicalis (Bt) are the primary tool for the diagnosis and immunotherapy of Allergic Rhinitis (AR), which is often associated with the Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). To diagnose OSAHS, 465 individuals were selected from the allergy registry of the Previsora Polyclinic, Camagüey, Cuba, with presumptive diagnosis of AR. Those with a skin test (Prick test) negative to Dp, Ds and Bt, and without a previous Cardiorespiratory Polygraphy (CRP) were discarded, leaving 236 patients between 8 and 70 years old: 102 cases (43.2 percent) those with oral breathing and snoring and 134 controls (56.7 percent) without oral breathing or snoring. The CRP data analysis was performed using the automatic algorithm of the ApneaLink AirTM device (Resmed Corp., Germany). The average size of the wheal was 5.9 mm in cases (p = 0.02). The Apnea Hypopnea Index (AHI) was greater than 5 events/hour in 129 patients (54.6 percent); of those, 97 cases (41.1 percent) and 32 controls (13.5 percent). Patients with AHI˃20/h predominated in cases with 21 individuals (8.8 percent) (p꞊0.048). The sensitivity of the PCR was 95.10 percent, its specificity 76.12 percent. The positive and negative predictive values were 75.19 percent and 95.33 percent respectively. The positive likelihood ratio was 3.98 and the negative one was 0.06. The prevalence of OSAHS was significantly higher in cases compared to controls (p =0.002). The CRP with the ApneaLink device allows the diagnosis of SAHOS in AR(AU)


Subject(s)
Skin Tests/methods , Sleep Apnea, Obstructive/diagnosis , Pyroglyphidae , Rhinitis, Allergic/diagnosis , Cuba
16.
Int. arch. otorhinolaryngol. (Impr.) ; 23(3): 325-330, July-Sept. 2019. tab
Article in English | LILACS (Americas) | ID: biblio-1040031

ABSTRACT

Abstract Introduction Oral antihistamines and intranasal corticosteroids have been shown to be effective and safe for the treatment of allergic rhinitis; however, the evidence suggests a level of superiority of corticosteroids, so they should be preferred over the former. Objective To know the prescription profile of two second generation antihistamines (cetirizine and levocetirizine) and two nasal corticosteroids (mometasone and furoateciclesonide) in a cohort of patients with allergic rhinitis, and to compare the clinical outcomes obtained. Methods A cohort study was carried including patients with allergic rhinitis treated with cetirizine, levocetirizine, mometasone furoate or ciclesonide. The improvement was evaluated with the total nasal symptoms score (TNSS). This scale yields results between 0 and 12. Zero indicates absence of symptoms. Results A total of 314 patients completed 12 weeks of follow-up. Seventy-five percent were treated with antihistamines, 20% with corticosteroids, and 5% with a combination of the above. The TNSS median for corticosteroid was 2.5 points; for antihistamines, its was 5 points, and for combination, it was 4 points. We found differences between corticosteroids and antihistamines. Conclusion The prescription percentage of second generation oral antihistamines is higher than that of intranasal corticosteroids. However, patients with allergic rhinitis treated with the second option obtained better control of symptoms.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Adrenal Cortex Hormones/therapeutic use , Rhinitis, Allergic/drug therapy , Histamine Antagonists/therapeutic use , Drug Prescriptions , Administration, Intranasal , Cohort Studies , Treatment Outcome , Cetirizine/therapeutic use , Adrenal Cortex Hormones/administration & dosage , Colombia , Mometasone Furoate/therapeutic use
17.
Distúrb. comun ; 31(2): 261-269, jun. 2019. ilus
Article in Portuguese | LILACS (Americas) | ID: biblio-1008214

ABSTRACT

Introdução: A asma e a rinite alérgica têm sido consideradas manifestações de uma mesma síndrome, uma vez que apresentam bases epidemiológicas, genéticas e fisiopatológicas comuns. A interação entre a dificuldade na função de respiração, a asma e a rinite alérgica podem promover alterações no sistema estomatognático, como as funções de mastigação e a deglutição, além de modificações anatômicas e funcionais, no crescimento facial e somático. Objetivo: Realizar uma revisão integrativa da avaliação da mastigação e deglutição em crianças e adolescentes com rinite e asma. Materiais e Métodos: Foi realizada uma pesquisa nas bases de dados Lilacs, MedLine, PubMed e Scielo, sobre artigos que abordavam a deglutição e mastigação em crianças e adolescentes com asma e rinite no período de janeiro e fevereiro de 2017, e a pesquisa foi atualizada em junho de 2018. Resultados: Foram encontrados 2.537 artigos, mas apenas cinco apresentaram os critérios de elegibilidade. Discussão: Poucos estudos referentes ao tema foram encontrados. Dos cinco artigos selecionados, três inferiram não encontrar alterações e dois encontraram padrões alterados, relacionando com o fator de obstrução nasal. É necessário que mais pesquisas sejam realizadas sobre o tema. Conclusão: Não há evidências científicas que afirmem a presença de alterações de mastigação e deglutição decorrentes da asma e da rinite em crianças e adolescentes.


Introduction: Asthma and allergic rhinitis have been considered as manifestations of the same syndrome, since they have common epidemiological, genetic and pathophysiological bases. The interaction between difficulty in breathing function, asthma and allergic rhinitis may promote changes in the stomatognathic system, such as chewing and swallowing functions, as well as anatomical and functional changes in facial and somatic growth. Objective: To perform an integrative review of chewing and swallowing assessment in children and teenagers with rhinitis and asthma. Materials and Methods: We searched the Lilacs, MedLine, PubMed and Scielo databases for articles on swallowing and chewing in children and teenagers with asthma and rhinitis in January and February 2017, and this research was updated in June 2018. Results: A total of 2,537 articles were found, but only five presented the eligibility criteria. Discussion: Few studies regarding the topic were found. Of the five articles selected, three inferred to find no alterations and two found altered patterns, relating to the nasal obstruction factor. More research is needed on the subject. Conclusion: There is no scientific evidence to support the presence of chewing and swallowing disorders due to asthma and rhinitis in children and teenagers.


Introducción: El asma y la rinitis alérgica se han considerado manifestaciones de un mismo síndrome, ya que presentan bases epidemiológicas, genéticas y fisiopatológicas comunes. La interacción entre la dificultad en la función de respiración, el asma y la rinitis alérgica pueden promover alteraciones en el sistema estomatognático, como las funciones de masticación y deglución, además de modificaciones anatómicas y funcionales, en el crecimiento facial y somático. Objetivo: Realizar una revisión integrativa de la evaluación de la masticación y deglución en niños y adolescentes con rinitis y asma. Materiales y Métodos: Se realizó una investigación en las bases de datos Lilacs, MedLine, PubMed y Scielo, sobre artículos que abordaban la deglución y masticación en niños y adolescentes con asma y rinitis en el período de enero y febrero de 2017, la investigación fue actualizada en junio de 2018. Resultados: Se encontraron 2.537 artículos, pero sólo cinco presentaron los criterios de elegibilidad. Discusión: Pocos estudios referentes al tema fueron encontrados. De los cinco artículos seleccionados, tres dedujeron no encontrar alteraciones y dos encontraron patrones alterados, relacionando con el factor de obstrucción nasal. Es necesario que más investigaciones se realicen sobre el tema. Conclusión: No hay evidencias científicas que afirmen la presencia de alteraciones de masticación y deglución derivadas del asma y de la rinitis en niños y adolescentes.


Subject(s)
Humans , Child , Adolescent , Asthma , Databases, Bibliographic , Deglutition , Speech, Language and Hearing Sciences , Rhinitis, Allergic , Mastication
18.
Acta otorrinolaringol. cir. cabeza cuello ; 47(1): 36-42, 2019. ^etab, grafilus
Article in Spanish | LILACS (Americas), COLNAL | ID: biblio-1053421

ABSTRACT

Introducción: La rinitis alérgica es una enfermedad común y prevalente que afecta aproximadamente el 32 % de la población colombiana. Clínicamente se caracteriza por estornudos, prurito nasal, rinorrea y obstrucción nasal. Debido a sus características inmunomoduladoras, los probióticos han sido blanco de diversos estudios en el manejo de la rinitis alérgica.Objetivo: Determinar la calidad de vida de pacientes con rinitis alérgica sin tratamiento médico y posterior a tratamiento con probióticos orales. Diseño: Observacional analítico tipo corte transversal. Metodología: 16 pacientes con diagnóstico de rinitis alérgica fueron analizados prospectivamente en la Clínica Pragma de Colombia, durante el período comprendido entre Enero a Abril de 2017. Se evaluaron los puntajes del cuestionario ESPRINT-15 validado en español, previo y posterior a 4 semanas de tratamiento con probióticos orales y antialérgico vía oral. Resultados: Posterior al ciclo vía oral de probióticos sistémicos se observa una reducción significativa en la severidad de síntomas, actividad, sueño y afectación psicológica con un Score ESPRINT-15 pretratamiento 4,42 respecto a un puntaje de ESPRINT-15 post tratamiento de 1,26 con un valor de p<0.001. Conclusiones: El uso de probióticos en pacientes con rinitis alérgica como terapia coadyuvante al tratamiento médico convencional con antihistamínicos disminuye los síntomas atópicos nasales y genera mejoría en la calidad de vida de los pacientes. Sin embargo, faltan estudios a largo plazo, una muestra más representativa y pruebas de su aplicabilidad en diversos grupos etarios para evaluar todos los posibles beneficios de esta terapia


Introduction: Allergic rhinitis is a common and prevalent disease that affects approximately 32% of the Colombian population. Clinically, they are classified as sneezing, nasal pruritus, rhinorrhea, and nasal obstruction. Due to its immunomodulatory characteristics, probiotics have been the target of various studies about the management of allergic rhinitis. Objective: To determine the quality of life of patients with allergic rhinitis prior to any medical treatment and after a treatment with oral probiotics. Design: Cross-sectional observational analytical study. Materials and methods: 16 patients diagnosed with allergic rhinitis were analyzed prospectively at the Pragma Clinic of Colombia between January-April 2017. The ESPRINT-15 (validated in Spanish) questionnaire scores, before and after 4 weeks of treatment with oral probiotics and oral antihistamines were assessed. Results: After completion of a comprehensive oral treatment of systemic probiotics, a significant reduction in the severity of symptoms, activity, sleep and psychological involvement was observed, with a 4.42 ESPRINT-15 score prior treatment in comparison with a 1.26 ESPRINT-15 score after treatment with a value of p < 0.001.Conclusions: The use of probiotics in patients with allergic rhinitis as adjuvant therapy to the conventional medical treatment with antihistamines, reduces the atopic nasal symptoms in this group of patients and improves their quality of life. Although there is a lack of long-term studies, more significant results and applicability in patients with different age groups in order to evaluate all possible benefits of this therapy. However, there is a lack of long-term studies, more representative samples and evidence of its applicability in various age groups to evaluate all the possible benefits of this therapy. Una vez diagnosticada, la Rinitis alérgica se puede cla-sificar en varios apartados según aparece en el mencionado documento ARIA, que utiliza parámetros de síntomas y cali-dad de vida para realizar la clasificación (Figura 1). Según la duración de los síntomas, hablaremos de rinitis intermitente o persistente y dependiendo de la gravedad de la misma y el impacto sobre la calidad de vida se trata de rinitis leve, moderada o grave (2,3).Figura 1. Clasificación de la duración y gravedad de la rinitis alérgica (ARIA 2001)2.En las regiones tropicales como nuestro país los facto-res ambientales como la humedad y un alto porcentaje de la población vive en zonas que normalmente superan los niveles de 65 a 70% de humedad (1,6,7) (Tabla 1), condi-ciones socioeconómicas y el pobre acceso a servicios de salud, pueden tener un impacto en el empeoramiento de las condiciones respiratorias de los pacientes con alergia en el tracto aéreo superior como asma y rinitis alérgica,


Subject(s)
Humans , Salaries and Fringe Benefits , Quality of Life , Rhinitis, Allergic
19.
Asia Pacific Allergy ; (4): e24-2019.
Article in English | WPRIM (Western Pacific) | ID: wprim-750187

ABSTRACT

BACKGROUND: Underdiagnosis and undertreatment of allergic rhinitis (AR) in patients with asthma can worsen treatment outcomes. There is limited evidence of clinical practices for management of coexistent AR-asthma in Thailand. METHODS: A multicountry, cross-sectional study (Asia-pacific Survey of Physicians on Asthma and allergic Rhinitis) to evaluate physician perceptions and management practices related to AR-asthma overlap in 6 Asian countries was conducted. For Thailand specifically, AR-asthma linkage questionnaires were developed and translated to Thailaland. General physicians (GPs) or pediatricians, randomly selected from hospitals in urban cities, routinely treating >10 asthma patients/month were interviewed. Here we present the results for Thailand. RESULTS: Two hundred physicians (100 GPs and 100 pediatricians), of whom 70% worked in government hospitals, were interviewed. In their experience, 50% of asthma patients had AR and 28% of AR patients had asthma. Among diagnosed asthma patients, 65% of physicians routinely asked for any AR symptoms at every visit. Among diagnosed AR patients, 63% of physicians routinely asked for any asthma symptoms at every visit. In patients with coexisting AR-asthma, 91% of physicians treated both diseases simultaneously, while 6% of physicians treated asthma as a chronic disease but managed AR symptomatically. The most preferred treatment options for patients with AR-asthma were inhaled corticosteroids with intranasal steroids (46% in GPs, 71% in pediatricians). CONCLUSION: The physicians interviewed in Thailand are aware about coexistent asthma-AR. There is a need to increase the awareness further for coexistent AR-asthma and to educate nonspecialist physicians in the proper management of AR-asthma patients.


Subject(s)
Adrenal Cortex Hormones , Asian Continental Ancestry Group , Asthma , Chronic Disease , Comorbidity , Cross-Sectional Studies , Humans , Rhinitis, Allergic , Steroids , Thailand
20.
Asia Pacific Allergy ; (4): e3-2019.
Article in English | WPRIM (Western Pacific) | ID: wprim-750171

ABSTRACT

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. He presented with a history of dry skin, eczema, and food allergy to egg. On clinical examination, his body temperature was 38.8°C, with dry skin and eczema almost all over the body, sparse eyebrows, and scalp hair. Laboratory investigations and physical examination did not show any evidence of infection. Radioallergosorbent test was positive to egg yolk, egg white, ovomucoid, milk, house dust, and house dust mite. As the child did not sweat despite the high fever, we performed the sweat test which revealed a total lack of sweat glands. Genetic examination revealed a mutation of the EDA gene and he was diagnosed as AED. His pyrexia improved upon cooling with ice and fan. His mother had lost 8 teeth and her sweat test demonstrated low sweating, suggestive of her being a carrier of AED. Atopy and immune deficiencies have been shown to have a higher prevalence in patients with AED. Disruption of the skin barrier in patients with AED make them more prone to allergic diseases such as atopic eczema, bronchial asthma, allergic rhinitis and food allergy. Careful assessment of the familial history is essential to differentiate AED when examining patients with pyrexia of unknown origin and comorbid allergic diseases.


Subject(s)
Asthma , Body Temperature , Child , Dermatitis, Atopic , Dust , Ectodermal Dysplasia , Eczema , Egg White , Egg Yolk , Eyebrows , Fever , Food Hypersensitivity , Hair , Humans , Hypohidrosis , Ice , Infant , Male , Milk , Mothers , Ovomucin , Ovum , Physical Examination , Prevalence , Pyroglyphidae , Radioallergosorbent Test , Rhinitis, Allergic , Scalp , Skin , Sweat , Sweat Glands , Sweating , Tooth
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