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1.
Medicina (B.Aires) ; 76(5): 317-320, Oct. 2016. mapas, tab
Article in Spanish | LILACS | ID: biblio-841601

ABSTRACT

Al quinto día de retirarse del Parque Nacional El Rey, provincia de Salta, Argentina, donde realizó turismo rural, una mujer italiana de 47 años desarrolló un cuadro febril agudo seguido de un exantema petequial y purpúrico que progresó rápidamente a falla multiorgánica y falleció al sexto día de internación. Existieron referencias a mordeduras por garrapatas y se constató una lesión cutánea similar a la denominada tache noire. La autopsia mostró una vasculitis generalizada, ascitis, edema de pulmón, necrosis tubular aguda y necrosis portal centrolobulillar. Se procesó tejido esplénico y hepático con técnica de PCR para Rickettsia spp, basada en la detección del gen gltA. El resultado fue positivo. Los amplicones obtenidos fueron secuenciados y los resultados se compararon con las secuencias preestablecidas en el programa BLAST, coincidiendo en un 99% con R. rickettsii. La baja sensibilidad del sistema de salud en reconocer la enfermedad y la insuficiente información producida desde los medios relacionados con el turismo, son factores que inciden en el retardo de implementar un tratamiento eficaz y las normas de prevención adecuadas.


On the fifth day after leaving the Parque Nacional El Rey, province of Salta, Argentina, where she made rural tourism, a woman of Italian origin, aged 47, developed an acute fever followed by a petechial and purpuric rash that progressed rapidly to multiorgan failure. She died on the sixth day after hospitalization. There were references to tick bites and a skin lesion similar to tache noire was found. The autopsy showed generalized vasculitis, ascites, pulmonary edema, acute tubular necrosis and portal centrilobular necrosis. Spleen and liver tissue were processed for PCR Rickettsia spp, based on the detection of the gltA gene. The result was positive. The amplicons obtained were sequenced and the results were compared with the preset sequences on the BLAST program, 99% coinciding with R. rickettsii. The low sensitivity of the health system to recognize this disease and the insufficient information generated from tourism-related media are factors that affect the delay to implement effective treatment and appropriate prevention standards.


Subject(s)
Humans , Animals , Female , Middle Aged , Rickettsia rickettsii/isolation & purification , Rocky Mountain Spotted Fever/microbiology , Argentina , Rocky Mountain Spotted Fever/complications , Fatal Outcome , Ixodidae/microbiology , Multiple Organ Failure/microbiology
2.
Rev. chil. infectol ; 31(1): 54-65, feb. 2014. ilus, tab
Article in Spanish | LILACS | ID: lil-706547

ABSTRACT

Tick-borne rickettsioses are worldwide infectious diseases that are considered emerging and re-emerging. Until recently the only tick-borne rickettsiosis present in Latin America was Rickettsia rickettsii infection, but to date, with the incorporation of new tools as PCR and sequencing and the quick cellular close tube cultures (Shell-vial), new species has been involved as human pathogens. In these guidelines, we offer an update of the microbiological assays for diagnosing rickettsioses. Besides we have included a section in which the most important hard ticks involved in human rickettsioses in Latinoamerica are detailed.


Las rickettsiosis transmitidas por garrapatas son afecciones de distribución mundial, que por diferentes motivos se pueden considerar emergentes y reemergentes. Hasta hace escasos años la única rickettsiosis transmitida por garrapatas en Latinoamérica era la infección por Rickettsia rickettsii, pero en la actualidad y fundamentalmente, gracias a la incorporación de nuevas herramientas para el diagnóstico microbiológico como la reacción en cadena de la polimerasa y secuenciación o el cultivo celular rápido en tubo cerrado, se han descrito e involucrado otras especies de Rickettsia en la producción de patología humana. En estas guías se detallan y describen las diferentes técnicas utilizadas para el diagnóstico microbiológico de las rickettsiosis. Además, se incluye una sección en la que se detallan las especies más importantes de garrapatas duras relacionadas con las rickettsiosis en Latinoamérica, con claves para su clasificación taxonómica.


Subject(s)
Animals , Humans , Arachnid Vectors/microbiology , Rickettsia Infections/diagnosis , Rickettsia/classification , Tick-Borne Diseases/diagnosis , Ticks/microbiology , Cell Culture Techniques , Fluorescent Antibody Technique, Indirect , Latin America , Polymerase Chain Reaction , Rickettsia Infections/microbiology , Rickettsia Infections/transmission , Rickettsia/isolation & purification , Rocky Mountain Spotted Fever/diagnosis , Rocky Mountain Spotted Fever/microbiology , Tick-Borne Diseases/microbiology , Ticks/anatomy & histology , Ticks/classification
3.
Mem. Inst. Oswaldo Cruz ; 103(7): 696-701, Nov. 2008. graf, tab
Article in English | LILACS, SES-SP | ID: lil-498380

ABSTRACT

The bacterium Rickettsia rickettsii is the etiological agent of an acute, severe disease called Rocky Mountain spotted fever in the United States or Brazilian spotted fever (BSF) in Brazil. In addition to these two countries, the disease has also been reported to affect humans in Mexico, Costa Rica, Panama, Colombia and Argentina. Like humans, dogs are also susceptible to R. rickettsii infection. However, despite the wide distribution of R. rickettsii in the Western Hemisphere, reports of R. rickettsii-induced illness in dogs has been restricted to the United States. The present study evaluated the pathogenicity for dogs of a South American strain of R. rickettsii. Three groups of dogs were evaluated: group 1 (G1) was inoculated ip with R. rickettsii; group 2 (G2) was infested by R. rickettsii-infected ticks; and the control group (G3) was infested by uninfected ticks. During the study, no clinical abnormalities, Rickettsia DNA or R. rickettsii-reactive antibodies were detected in G3. In contrast, all G1 and G2 dogs developed signs of rickettsial infection, i.e., fever, lethargy, anorexia, ocular lesions, thrombocytopenia, anemia and detectable levels of Rickettsia DNA and R. rickettsii-reactive antibodies in their blood. Rickettsemia started 3-8 days after inoculation or tick infestation and lasted for 3-13 days. Our results indicate that a Brazilian strain of R. rickettsii is pathogenic for dogs, suggesting that canine clinical illness due to R. rickettsii has been unreported in Brazil and possibly in the other South American countries where BSF has been reported among humans.


Subject(s)
Animals , Dogs , Female , DNA, Bacterial/blood , Dog Diseases/microbiology , Rickettsia rickettsii/pathogenicity , Rocky Mountain Spotted Fever/veterinary , Ticks/microbiology , Disease Models, Animal , Dog Diseases/transmission , Rocky Mountain Spotted Fever/microbiology , Rocky Mountain Spotted Fever/transmission
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