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1.
An. bras. dermatol ; 96(2): 163-170, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1248745

ABSTRACT

Abstract Background: Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. Objective: To evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity. Methods: Cross-sectional study. Sample comprised the following groups: healthy controls without periodontitis or with mild periodontitis (n = 21), healthy controls with moderate or severe periodontitis (n = 18), individuals with psoriasis without or mild periodontitis (n = 11), and individuals with psoriasis and moderate or severe periodontitis (n = 32). Levels of IL-17A, IL-22, IL-23, S100A8, and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA. Results: No inter-group differences in the levels of IL-17A, IL-22, IL-23, and S100A7 were found. S100A8 levels were higher in psoriatic patients than controls (p < 0.05). S100A8 was positively correlated with psoriasis severity in the group with psoriasis (p < 0.05). S100A9 exceeded the detection limits. Study limitations: This pilot study presents a small sample size. Conclusions: The concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health/status. S100A8 was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis vs. healthy controls.


Subject(s)
Humans , Periodontitis , Gingival Crevicular Fluid , S100 Proteins , Pilot Projects , Cross-Sectional Studies , Interleukins , Interleukin-17 , Calgranulin A , Interleukin-23 Subunit p19
2.
An. bras. dermatol ; 95(2): 173-179, Mar.-Apr. 2020. tab
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130863

ABSTRACT

Abstract Background: Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal differentiation complex on chromosome 1q21. Objective: To evaluate the polymorphisms in the filaggrin 2 gene (rs 12568784 and rs 16899374) in children and adults with atopic dermatitis and to verify the association of these with the severity of the clinical picture, presence of other allergic diseases, and socio-demographic factors. Method: The study was carried out with patients and control group. Questionnaires were used to evaluate ethnicity, sex, age, family history, scoring, atopic dermatitis (SCORAD), among other parameters. Genotyping of the filaggrin 2 gene was performed by real-time polymerase chain reaction. Results: Forty-eight patients and 83 controls were evaluated. No correlation was found between the variables studied in patients with atopic dermatitis and polymorphisms, no significant difference between the prevalence of polymorphisms in the patients and in the control group p > 0.05. Study limits: The exclusive use of self-reported ethnicity information and the sample size. Results: The results of this work can be an incentive for the study of the polymorphisms in atopic dermaititis, considering the characteristic of the Brazilian multi ethnic population. Conclusion: This is an unpublished work in Brazil and the first study in the world to have a control group to evaluate alterations in the gene of filaggrin 2.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Young Adult , Polymorphism, Genetic/genetics , S100 Proteins/genetics , Dermatitis, Atopic/genetics , Socioeconomic Factors , Severity of Illness Index , Brazil , Case-Control Studies , Sex Factors , Cross-Sectional Studies , Surveys and Questionnaires , Dermatitis, Atopic/ethnology , Dermatitis, Atopic/pathology , Real-Time Polymerase Chain Reaction
3.
Autops. Case Rep ; 9(3): e2019099, July-Sept. 2019. ilus, tab
Article in English | LILACS | ID: biblio-1020994

ABSTRACT

Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.


Subject(s)
Humans , Female , Child, Preschool , Breast Neoplasms/pathology , Granular Cell Tumor/pathology , Schwann Cells/pathology , S100 Proteins
4.
Rev. bras. cir. cardiovasc ; 34(4): 464-471, July-Aug. 2019. tab
Article in English | LILACS | ID: biblio-1020500

ABSTRACT

Abstract Objective: Cerebrospinal fluid (CSF) drainage is a technique that has significantly reduced the incidence of spinal cord ischaemia (SCI). We present results of a systematic review to assess the literature on this topic in relation to thoracoabdominal aortic aneurysm repair (TAAR). Methods: Major medical databases were searched to identify papers related to CSF biomarkers measured during TAAAR. Results: Fifteen papers reported measurements of CSF biomarkers with 265 patients in total. CSF biomarkers measured included S-100ß, neuron-specific endolase (NSE), lactate, glial fibrillary acidic protein A (GFPa), Tau, heat shock protein 70 and 27 (HSP70, HSP27), and proinflammatory cytokines. Lactate and S-100ß were reported the most, but did not correlate with SCI, which was also the case with NSE and TAU. GFPa showed significant CSF level rises, both intra and postoperative in patients who suffered SCI and warrants further investigation, similar results were seen with HSP70, HSP27 and IL-8. Conclusions: Although there is significant interest in this topic, there still remains a significant lack of high-quality studies investigating CSF biomarkers during TAAR to detect SCI. A large and multicentre study is required to identify the significant role of each biomarker.


Subject(s)
Humans , Phosphopyruvate Hydratase/blood , Biomarkers/cerebrospinal fluid , Aortic Aneurysm, Thoracic/surgery , Spinal Cord Ischemia/cerebrospinal fluid , Electrochemical Techniques/methods , Biomarkers/blood , S100 Proteins/cerebrospinal fluid , S100 Proteins/blood , Drainage , Lactic Acid/cerebrospinal fluid , Lactic Acid/blood , Spinal Cord Ischemia/blood
5.
Rev. cir. traumatol. buco-maxilo-fac ; 19(4): 7-12, out.-dez. 2019. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-1253605

ABSTRACT

Introdução: Os tumores neurais são lesões, que têm origem nos nervos periféricos e representam um percentual de 45% dos neoplasmas, que atingem a região de cabeça e pescoço. A alta incidência nessa área é justificada pela quantidade relativamente grande de terminações nervosas periféricas agrupadas. Ainda que sejam de mesma origem neural, sua heterogeneidade microscópica e patogenética lhes conferem um variado padrão de apresentação clínica e histopatológica, diferindo na sua forma de tratamento. O objetivo do presente estudo foi analisar, por meio da técnica imuno-histoquímica, a expressão das proteínas S100 e CD68 em tumores neurais, localizados na cavidade bucal de pacientes atendidos no Serviço de Patologia Bucal da Universidade de Odontologia de Pernambuco. Metodologia: Todos os casos referentes a tumores neurais do Serviço de Patologia oral e maxilofacial da Faculdade de Odontologia de Pernambuco foram revistos. Avaliaram-se dados relativos à idade, ao sexo e à localização anatômica. A técnica imunohistoquímica foi realizada por meio do método estreptavidina-biotina, utilizando-se os anticorpos anti: S100 e CD68. A análise foi feita de forma descritiva, conforme dados da pesquisa. Resultados: foram avaliados 23 casos de tumores neurais da cavidade bucal, 15 neurofibromas, 6 neuromas traumáticos, 1 neurilemoma e 1 neuroma encapsulado em paliçada. Verificou-se que a proteína S100 foi expressa em todos os casos estudados com positividade variada, e a proteína CD68 apresentou expressão positiva em 18 casos (neuroma traumático, neurofibroma). Conclusões: os tumores neurais da cavidade bucal foram considerados raros, visto que ocorreram em apenas 23 casos entre 5.761, ou seja, em 2,3% das lesões biopsiadas da FOP-UPE... (AU)


Introduction: Neural tumors are lesions that originate from peripheral nerves and represent a percentage of 45% of neoplasms that reach the head and neck region. The high incidence in this area is explained by the relatively large number of grouped peripheral nerve endings. Although they are of the same neural origin, their microscopic and pathogenetic heterogeneity give them a varied pattern of clinical and histopathological presentation, as well as differing in their form of treatment. The aim of the present study was to analyze by immunohistochemical technique the expression of S100 and CD68 proteins in neural tumors located in the oral cavity of patients treated at the Oral Pathology Service of the University of Dentistry of Pernambuco. Methodology: All cases referring to neural tumors of the Service of Oral and Maxillofacial Pathology of the School of Dentistry of Pernambuco were reviewed. Data regarding age, sex, and anatomical location were evaluated. The immunohistochemical technique was performed by the streptavidin-biotin method using the anti-S100 and CD68 antibodies. The analysis was made in a descriptive way according to the research data. Results: 23 cases of neural tumors of the buccal cavity, 15 neurofibromas, 6 traumatic neuromas, 1 neurilemoma and 1 palisade encapsulated neuroma were evaluated. It was verified that S100 protein was expressed in all the cases studied with varied positivity, and the CD68 protein showed positive expression in 18 cases (traumatic neuroma, neurofibroma). Conclusions: Neural tumors of the oral cavity were considered rare, since they occurred in only 23 cases among 5,761, that is, 2.3% of FOP-UPE biopsied lesions... (AU)


Subject(s)
Humans , Male , Female , Pathology, Oral , Peripheral Nerves , Immunohistochemistry , S100 Proteins , Incidence , Neoplasms , Dentistry , Mouth , Nerve Endings
6.
An. bras. dermatol ; 94(1): 79-81, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-983755

ABSTRACT

Abstract: We report the case of a 47-year-old male patient with S100 negative granular cell tumor of the oral cavity, focusing on dermoscopic features as well as surgical approach, not previously reported in the literature. The study contributes to the literature on dermoscopy and surgical treatment for this tumor and provides a practical approach to differentiating non-neural granular cell tumors and granular cell tumors.


Subject(s)
Humans , Male , Middle Aged , Mouth Neoplasms/surgery , Mouth Neoplasms/pathology , Mouth Neoplasms/chemistry , Mouth Neoplasms/diagnostic imaging , S100 Proteins , Granular Cell Tumor/surgery , Granular Cell Tumor/pathology , Granular Cell Tumor/chemistry , Granular Cell Tumor/diagnostic imaging , Dermoscopy/methods , Treatment Outcome
7.
Article in English | WPRIM | ID: wpr-765631

ABSTRACT

STUDY DESIGN: Case report. OBJECTIVES: We report a case of paraspinal ancient schwannoma located at the upper thoracic level that mimicked an atypical lipoma or complicated epidermoid cyst. SUMMARY OF LITERATURE REVIEW: Few case reports of paraspinal schwannoma have been reported and the incidence of ancient schwannoma in the paraspinal muscle layer is very rare. MATERIALS AND METHODS: A 39-year-old man complained of a growing palpable back mass for 5 years. He experienced aggravated chronic discomfort around the mass while lying down. Both T1- and T2- weighted magnetic resonance imaging (MRI) showed a well-capsuled and heterogeneous high-signal mass in the muscle layer at the level from the T1 to T4 vertebral bodies on the right side of the midline. The tumor was completely removed by en bloc resection. RESULTS: The pathologic examination revealed S-100 protein expression with degenerative changes. The lesion was diagnosed as an ancient schwannoma. CONCLUSIONS: Schwannoma is one among the multiple possible causes of benign back masses. If a mass reveals a well-encapsulated heterogeneous mass on contrast MRI, a schwannoma should be suspected.


Subject(s)
Adult , Back Muscles , Deception , Epidermal Cyst , Humans , Incidence , Lipoma , Magnetic Resonance Imaging , Neurilemmoma , Paraspinal Muscles , S100 Proteins
8.
Article in Korean | WPRIM | ID: wpr-759733

ABSTRACT

BACKGROUND: Juvenile xanthogranuloma is a benign, self-limited disorder that usually occurs in infants and young children. Xanthogranuloma is rare in adults, and therefore studies reporting adult xanthogranuloma are limited. OBJECTIVE: We investigated the clinical, histopathological, and immunohistochemical characteristics of adult xanthogranuloma. METHODS: In this study, we evaluated 20 lesions in 19 patients with adult xanthogranuloma. RESULTS: A male predominance was observed (male : female ratio 1.4 : 1), and the mean age of patients was 35.1±16.3 years (range 15∼66 years), with the peak incidence observed in patients in their 20s. Notably, 65.0% of the lesions developed on the head and neck. The nodular form was more common than the papular form of this condition. Histopathological examination revealed dense monomorphic histiocytic infiltration without lipidization and scattered eosinophils without multinuclear giant cells in 5 lesions (25.0%), foamy histiocytic infiltration with variations of completely developed Touton giant cells in 10 lesions (50.0%), and fibrohistiocytic proliferation in 3 lesions (15.0%). On immunohistochemical examination, histiocytes including giant cells showed positive test results with Factor XIIIa (90.9%), vimentin (100%), and CD68 (100%) and negative test results with CD1a, smooth muscle actin, and S-100 protein stains. Tumor excision was the treatment for choice. CONCLUSION: Adult xanthogranuloma most commonly manifested as the nodular form of the disease on the head and neck of men in their late 20s. Histopathologically, the classic Touton cell-rich stage was most commonly observed, followed by the stage of early predominantly mononuclear infiltration. This was a single-center, small-sized retrospective study; however, we expect the results of this study to contribute to a better understanding of adult xanthogranuloma.


Subject(s)
Actins , Adult , Child , Coloring Agents , Eosinophils , Factor XIIIa , Female , Giant Cells , Head , Histiocytes , Humans , Incidence , Infant , Male , Muscle, Smooth , Neck , Retrospective Studies , S100 Proteins , Vimentin , Xanthogranuloma, Juvenile
9.
Acta Physiologica Sinica ; (6): 279-286, 2019.
Article in Chinese | WPRIM | ID: wpr-777188

ABSTRACT

The aim of this study was to investigate the role of S100 calcium binding protein A16 (S100A16) in lipid metabolism in hepatocytes and its possible biological mechanism. HepG2 cells (human hepatoma cell line) were cultured with fatty acid to establish fatty acid culture model. The control model was cultured without fatty acid. Each model was divided into three groups and transfected with S100a16 over-expression, shRNA and vector plasmids, respectively. The concentration of triglyceride (TG) in the cells was measured by kit, and the lipid droplets was observed by oil red O staining. Immunoprecipitation and mass spectrometry were used to find the interesting proteins interacting with S100A16, and the interaction was verified by immunoprecipitation. The further mechanism was studied by Western blot and qRT-PCR. The results showed that the intracellular lipid droplet and TG concentrations in the fatty acid culture model were significantly higher than those in the control model. The accumulation of intracellular fat in the S100a16 over-expression group was significantly higher than that in the vector plasmid transfection group. There was an interaction between heat shock protein A5 (HSPA5) and S100A16. Over-expression of S100A16 up-regulated protein expression levels of HSPA5, inositol-requiring enzyme 1α (IRE1α) and pIREα1, which belong to endoplasmic reticulum stress HSPA5/IRE1α-XBP1 pathway. Meanwhile, over-expression of S100A16 up-regulated the mRNA expression levels of adipose synthesis-related gene Srebp1c, Acc and Fas. In the S100a16 shRNA plasmid transfection group, the above-mentioned protein and mRNA levels were lower than those of vector plasmid transfection group. These results suggest that S100A16 may promote lipid synthesis in HepG2 cells through endoplasmic reticulum stress HSPA5/IRE1α-XBP1 pathway.


Subject(s)
Endoplasmic Reticulum Stress , Endoribonucleases , Physiology , Heat-Shock Proteins , Physiology , Hep G2 Cells , Humans , Lipid Metabolism , Protein-Serine-Threonine Kinases , Physiology , S100 Proteins , Physiology , Triglycerides , X-Box Binding Protein 1 , Physiology
10.
Article in English | WPRIM | ID: wpr-718719

ABSTRACT

OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and S100 proteins within the first 24 hours after the return of spontaneous circulation were associated with good neurological outcomes in cardiac arrest survivors. METHODS: This retrospective observational study was based on prospectively collected data from a single emergency intensive care unit (ICU). Twenty-nine out-of-hospital cardiac arrest survivors who were admitted to the ICU for post-resuscitation care were enrolled. Blood samples were collected at 0 and 24 hours after ICU admission. According to the 6-month cerebral performance category (CPC) scale, the patients were divided into good (CPC 1 and 2, n=12) and poor (CPC 3 to 5, n=17) outcome groups. RESULTS: No difference was observed between the two groups in terms of the serum levels of ICAM-1, VCAM-1, E-selectin, and S100 at 0 and 24 hours. A simultaneous decrease in the serum levels of VCAM-1 and S100 as well as E-selectin and S100 was associated with good neurological outcomes. When other variables were adjusted, a simultaneous decrease in the serum levels of VCAM-1 and S100 was independently associated with good neurological outcomes (odds ratio, 9.285; 95% confidence interval, 1.073 to 80.318; P=0.043). CONCLUSION: A simultaneous decrease in the serum levels of soluble VCAM-1 and S100 within the first 24 hours after the return of spontaneous circulation was associated with a good neurological outcome in out-of-hospital cardiac arrest survivors.


Subject(s)
Blood-Brain Barrier , Cardiopulmonary Resuscitation , Cell Adhesion , Cell Adhesion Molecules , E-Selectin , Emergencies , Endothelium , Heart Arrest , Humans , Intensive Care Units , Intercellular Adhesion Molecule-1 , Observational Study , Out-of-Hospital Cardiac Arrest , Prospective Studies , Retrospective Studies , S100 Proteins , Survivors , Vascular Cell Adhesion Molecule-1
11.
Article in Korean | WPRIM | ID: wpr-717115

ABSTRACT

A primary benign schwannoma of the liver is extremely rare. Only 30 cases have been reported in the medical literature worldwide, and only one case has been reported in Korea previously. A 56-year-old man was admitted to Gil Medical Center with incidental findings of a hepatic mass by abdominal computed tomography. The computed tomography and magnetic resonance image revealed a 3×2 cm-sized solid mass in the left lobe of the liver. Histological examination confirmed the diagnosis of a benign schwannoma, proven by positive immunoreaction with the neurogenic marker S-100 protein and a negative response to CD34, CD117, and smooth muscle actin. We report a primary benign schwannoma of the liver and review the literature.


Subject(s)
Actins , Diagnosis , Humans , Incidental Findings , Korea , Liver , Middle Aged , Muscle, Smooth , Neurilemmoma , Peripheral Nervous System Neoplasms , S100 Proteins
12.
Immune Network ; : e27-2018.
Article in English | WPRIM | ID: wpr-716244

ABSTRACT

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.


Subject(s)
Alzheimer Disease , Arthritis, Rheumatoid , Atherosclerosis , Biomarkers , Heat-Shock Proteins , Immune System , Inflammation , Lupus Erythematosus, Systemic , Osteoarthritis , Parkinson Disease , Receptors, Pattern Recognition , S100 Proteins
14.
Article in English | WPRIM | ID: wpr-184096

ABSTRACT

Microglandular adenosis (MGA) of the breast is a rare, benign proliferative lesion but with a significant rate of associated carcinoma. Herein, we report an unusual case of metaplastic carcinoma with chondroid differentiation associated with typical MGA. Histologically, MGA showed a direct transition to metaplastic carcinoma without an intervening atypical MGA or ductal carcinoma in situ component. The immunohistochemical profile of the metaplastic carcinoma was mostly similar to that of MGA. In both areas, all the epithelial cells were positive for S-100 protein, but negative for estrogen receptor, progesterone receptor, HER2/neu, and epidermal growth factor receptor. An increase in the Ki-67 and p53 labelling index was observed from MGA to invasive carcinoma. To the best of our knowledge, this is the first case of metaplastic carcinoma with chondroid differentiation arising in MGA in Korea. This case supports the hypothesis that a subset of MGA may be a non-obligate morphologic precursor of breast carcinoma, especially the triple-negative subtype.


Subject(s)
Breast , Breast Neoplasms , Carcinoma, Intraductal, Noninfiltrating , Epithelial Cells , Estrogens , Fibrocystic Breast Disease , Korea , ErbB Receptors , Receptors, Progesterone , S100 Proteins
15.
Article in English | WPRIM | ID: wpr-184095

ABSTRACT

Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.


Subject(s)
Acinar Cells , Breast , Carcinoma, Intraductal, Noninfiltrating , Fibrocystic Breast Disease , Follow-Up Studies , Humans , Recurrence , S100 Proteins , Triple Negative Breast Neoplasms
16.
Annals of Dermatology ; : 776-778, 2017.
Article in English | WPRIM | ID: wpr-225292

ABSTRACT

A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS.


Subject(s)
Biopsy , Child , Coloring Agents , Cytoplasm , Forearm , Granular Cell Tumor , Humans , Infant , Nevus , Parturition , S100 Proteins , Vimentin
17.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 54(4): 420-424, 2017. ilus
Article in English | LILACS, VETINDEX | ID: biblio-912055

ABSTRACT

Malignant peripheral nerve sheath tumor is rare and rarely reported in dogs. The term neurofibroma/sarcoma is classically used when the tumor is composed of Schawann and perineural cells. This work describes the clinical, histopathological, and immunohistochemical case of a subcutaneous malignant peripheral nerve sheath tumor, most likely a malignant neurofibroma located in the pelvic member of a Rottweiler dog. Histopathological features and immunohistochemical analysis corroborated the diagnosis, showing positivity for S-100 protein, vimentin, and CD57, and was useful to distinguish this type of neoplasm from other malignancies of similar morphologies.(AU)


O tumor maligno da bainha do nervo periférico é raro e pouco descrito em cães. Classicamente, o termo "neurofibroma/sarcoma" é empregado quando o tumor é composto por células de Schwann e células perineurais. Neste relato são descritos os achados clínicos, histopatológicos e imuno-histoquímicos de um caso de tumor maligno da bainha do nervo periférico, provavelmente neurofibrossarcoma, localizado no subcutâneo do membro pélvico de um cão da raça Rottweiler. Os achados histopatológicos associados às observações imuno-histoquímicas contribuíram para o diagnóstico, sendo observada positividade para proteína S-100, vimentina e CD57, permitindo a diferenciação da neoplasia em questão de outros tumores malignos com características morfológicas similares.(AU)


Subject(s)
Animals , Dogs , Biomarkers, Tumor/analysis , Neurofibrosarcoma/veterinary , Pelvis , CD57 Antigens , Immunohistochemistry/veterinary , Nerve Sheath Neoplasms/veterinary , S100 Proteins , Vimentin
18.
Article in Korean | WPRIM | ID: wpr-179981

ABSTRACT

PURPOSE: Solitary plexiform neurofibroma of the eyelid without neurofibromatosis is a rare disease. We report a case of solitary plexiform pigmented neurofibroma of the eyelid without neurofibromatosis. CASE SUMMARY: A 12-year-old male visited our clinic with a painless palpable subcutaneous mass on the right lower eyelid. He had a history of Batter syndrome and attention deficit hyperactivity disorder. On initial presentation, clinical features regarding neurofibromatosis such as Lisch nodule, optic nerve glioma, or high myopia were not observed. We performed excision and biopsy of the lower lid mass under general anesthesia. Macroscopically, the tumor was 4.0 × 1.5 × 1.5 cm in size with irregular nodules. Microscopically, the tumor consisted of multiple, variably sized tortous enlarged nerve fascicles with clusters of pigmented cells. Immunohistochemical results revealed expression of S-100 protein. Pigmented cells express both S-100 and melan-A proteins, while nonpigmented cells express S-100 protein only. The tumor was finally diagnosed as plexiform pigmented neurofibroma. Dermatological evaluation revealed no evidence of systemic neurofibromatosis. CONCLUSIONS: Plexiform neurofibroma should be considered in the differential diagnosis of an eyelid mass, even if the patient does not have a history or clinical features of neurofibromatosis. Plexiform neurofibroma can be successfully managed with surgical excision.


Subject(s)
Anesthesia, General , Attention Deficit Disorder with Hyperactivity , Biopsy , Child , Diagnosis, Differential , Eyelids , Humans , Male , MART-1 Antigen , Myopia , Neurofibroma , Neurofibroma, Plexiform , Neurofibromatoses , Neurofibromatosis 1 , Optic Nerve Glioma , Rare Diseases , S100 Proteins
19.
Article in Korean | WPRIM | ID: wpr-56578

ABSTRACT

PURPOSE: To report a rare case of upper eyelid schwannoma presenting as a chalazion. CASE SUMMARY: A 54-year-old male presented to our clinic with a slowly growing, painless recurred mass located in the middle area of the right upper eyelid margin. Surgical incision had been performed on a similar mass two year previous, although no histological analysis had been performed. On examination, a 4 × 3-mm-sized, firm, nonpigmented mass was palpable in the right upper eyelid, and no signs of neurofibromatosis were present elsewhere. The lesion was initially thought to be an eyelid mass, so we performed an excisional biopsy under local anesthesia. The lesion was easily isolated from the surrounding tissue and was excised completely. Histopathologically, the excised mass showed a compact arrangement of spindle cells forming palisades with Verocay bodies (Antoni A patterns). Immunohistochemistry revealed diffuse and strong S-100 protein positivity. These findings resulted in the diagnosis of eyelid schwannoma. CONCLUSIONS: Because of its rarity and solitary feature, eyelid schwannoma can be confused with chalazion. Thus, ophthalmologists should consider schwannoma in the differential diagnosis of a slowly growing, painless recurred mass or a lesion with malignant transformation after incomplete excision.


Subject(s)
Anesthesia, Local , Biopsy , Chalazion , Diagnosis , Diagnosis, Differential , Eyelids , Humans , Immunohistochemistry , Male , Middle Aged , Neurilemmoma , Neurofibromatoses , S100 Proteins
20.
Article in Korean | WPRIM | ID: wpr-53858

ABSTRACT

Hyalinizing Spitz nevus was first introduced in 1994 by Suster. It is considered a rare variant in the spectrum of Spitz nevus, with only a dozen cases having been reported to date. Herein we report a case of a 28-year-old Korean woman who had a brown papular lesion on the left palm, which was diagnosed as hyalinizing Spitz nevus. Upon histopathological investigation, discohesive growth patterns of nevus cells in a hyalinized stroma were noted. Immunohistochemical stains showed positive reactivity of nevus cells with S-100 protein and vimentin, but negative stains with HMB-45 and CD68. This case demonstrates a rare variant of Spitz nevus located on an unusual site, and calls for awareness in the diagnosis of cutaneous lesions that histologically exhibit a prominent hyalinized stroma.


Subject(s)
Adult , Biopsy , Coloring Agents , Diagnosis , Diagnosis, Differential , Female , Humans , Hyalin , Nevus , Nevus, Epithelioid and Spindle Cell , S100 Proteins , Vimentin
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