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1.
Article in Chinese | WPRIM | ID: wpr-927886

ABSTRACT

Ewing's sarcoma in the cervix is characterized by extremely rare occurrence,high degree of malignancy,and rapid progression.The diagnosis of this disease is based on pathology and immunohistochemistry. The main image of the case reported in this paper showed the cervical cyst with solid mass,large volume,and uneven density and signal,and the solid part can be strengthened in enhanced scanning.Because of the rapid growth,the lesion is prone to liquefaction necrosis and bleeding.Since the metastasis occurs early,timely diagnosis is essential.


Subject(s)
Cervix Uteri/pathology , Female , Humans , Immunohistochemistry , Neuroectodermal Tumors, Primitive, Peripheral/pathology , Sarcoma, Ewing/pathology , Uterine Cervical Neoplasms
2.
Autops. Case Rep ; 10(3): e2020199, 2020. tab, graf
Article in English | LILACS | ID: biblio-1131830

ABSTRACT

We present the autopsy findings and differential diagnosis in a 42year old male who presented with fever and rapidly progressive respiratory symptoms like breathlessness, nonproductive cough and right sided chest pain. Initial imaging workup done at our hospital revealed a large unilateral tumor with tracheal shift. While being evaluated patient developed facial puffiness, tachypnea suggestive of superior vena cava obstruction. Antemortem biopsy of lung mass was attempted twice and that suggested malignant lesion. Unfortunately, the individual had a rapid downhill course following admission. Post mortem examination was conducted that on opening the thoracic cavity revealed total replacement of right lung tissue by a necrotic growth which was deeply adherent to the rib cage. The contralateral lung as well as all other visceral organs were unremarkable grossly. Histopathology confirmed primary Ewing sarcoma of the lung. We hereby, report a rare case of primary lung Ewing sarcoma diagnosed at autopsy.


Subject(s)
Humans , Male , Adult , Sarcoma, Ewing/pathology , Bone Neoplasms/pathology , Neuroectodermal Tumors/pathology , Lung Neoplasms/pathology , Autopsy , Fatal Outcome , Diagnosis, Differential
4.
Clin. biomed. res ; 37(3): 263-265, 2017. ilus
Article in Portuguese | LILACS | ID: biblio-859867

ABSTRACT

O sarcoma congênito da família Ewing é uma doença extremamente rara, que se manifesta através do surgimento de uma massa e sinais sistêmicos como dor e febre. Cerca de 70 a 80% dos casos ocorrem antes dos 20 anos de idade. Histologicamente se caracteriza pela presença de pequenas células arredondadas e azuis. Além disso, pode se manifestar em tecidos moles ou osso e em qualquer parte do corpo, sendo a forma congênita mais comumente encontrada nas extremidades. O diagnóstico é estabelecido através de exames de imagem, histopatologia e imuno-histoquímica. Esses tumores costumam ser agressivos e apresentar elevada mortalidade. Aqui, relatamos o caso de um recém-nascido que apresentou uma massa no membro superior esquerdo diagnosticada como sarcoma congênito da família Ewing por biópsia cutânea por punch e pela presença do marcador CD99 (AU)


Congenital Ewing's sarcoma is an extremely rare disease, manifested by the appearance of a mass and systemic signs such as pain and fever. About 70-80% of cases occur before 20 years of age. This condition is histologically characterized by the presence of small round blue cells and can manifest in bone or soft tissue, anywhere in the body, with the congenital form being the most commonly found in the extremities. The diagnosis is established by imaging, histopathology, and immunohistochemistry. These tumors tend to be aggressive and have high mortality rates. Here, we report the case of a newborn who presented a mass in the left upper limb diagnosed as congenital Ewing's sarcoma by punch skin biopsy and the presence of the CD99 marker (AU)


Subject(s)
Humans , Male , Infant, Newborn , Sarcoma, Ewing/congenital , Bone Neoplasms/congenital , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Neuroectodermal Tumors, Primitive, Peripheral/congenital , Sarcoma, Ewing/diagnostic imaging , Sarcoma, Ewing/pathology
5.
Article in English | WPRIM | ID: wpr-22492

ABSTRACT

OBJECTIVE: To comprehensively analyze the spectrum of imaging features of the primary tumors and metastatic patterns of the Extraskeletal Ewing sarcoma family of tumors (EES) in adults. MATERIALS AND METHODS: We performed a computerized search of our hospital's data-warehouse from 1996 to 2013 using codes for Ewing sarcoma and primitive neuroectodermal tumors as well as the demographic code for > or = 18 years of age. We selected subjects who were histologically confirmed to have Ewing sarcoma of extraskeletal origin. Imaging features of the primary tumor and metastatic disease were evaluated for lesion location, size, enhancement pattern, necrosis, margin, and invasion of adjacent organs. RESULTS: Among the 70 patients (mean age, 35.8 +/- 15.6 years; range, 18-67 years) included in our study, primary tumors of EES occurred in the soft tissue and extremities (n = 20), abdomen and pelvis (n = 18), thorax (n = 14), paravertebral space (n = 8), head and neck (n = 6), and an unknown primary site (n = 4). Most primary tumors manifested as large and bulky soft-tissue masses (mean size, 9.0 cm; range, 1.3-23.0 cm), frequently invading adjacent organs (45.6%) and showed heterogeneous enhancement (73.7%), a well-defined (66.7%) margin, and partial necrosis/cystic degeneration (81.9%). Notably, 29 patients had metastatic disease detected at their initial diagnosis. The most frequent site of metastasis was lymph nodes (75.9%), followed by bone (31.0%), lung (20.7%), abdominal solid organs (13.8%), peritoneum (13.8%), pleura (6.9%), and brain (3.4%). CONCLUSION: Primary tumors of EES can occur anywhere and mostly manifest as large and bulky, soft-tissue masses. Lymph nodes are the most frequent metastasis sites.


Subject(s)
Adolescent , Adult , Aged , Asians , Bone Neoplasms/pathology , Brain Neoplasms/pathology , Female , Humans , Lymph Nodes/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Metastasis , Neuroectodermal Tumors, Primitive/pathology , Positron-Emission Tomography , Sarcoma, Ewing/pathology , Tomography, X-Ray Computed , Young Adult
6.
An. bras. dermatol ; 89(3): 501-503, May-Jun/2014. graf
Article in English | LILACS | ID: lil-711621

ABSTRACT

Ewing sarcoma is a primitive neuroectodermal tumor rarely occurs in the skin and sobcutaneous tissues. Generally Ewing's sarcoma is a primary bone tumor, but when present in soft tissues it characterizes an extremely uncommon clinical picture. It usually involves the deep subcutaneous tissue or muscles, and more rarely occurs like a primary skin cancer. Most patients are white, women, and in the second decade of life. The clinical features are a superficial mass, in average measuring 2-3 cm, of soft consistency, freely mobile and sometimes painful. The more affected locations are upper and lower extremities, trunk, head, neck or multiple lesions. The presence of metastases is very rare.


Subject(s)
Adult , Female , Humans , Sarcoma, Ewing/pathology , Skin Neoplasms/pathology , Subcutaneous Tissue/pathology , Diagnosis, Differential
7.
Article in English | IMSEAR | ID: sea-154391

ABSTRACT

Askin tumour, a primitive neuroectodermal tumour of the thoracopulmonary region, is a rare tumour presenting in childhood. Its presentation in adults is rare. We report a case of an Askin tumour in an adult patient who presented to us with worsening breathlessness and vague chest pain. Investigations including immunohistochemistry confirmed the diagnosis of Askin tumour.


Subject(s)
Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Biopsy , Bone Neoplasms/drug therapy , Bone Neoplasms/pathology , Bone Neoplasms/physiopathology , Disease Progression , Humans , Lung/pathology , Lung Neoplasms/pathology , Lymphatic Metastasis , Male , Neuroectodermal Tumors, Primitive, Peripheral/pathology , /secondary , Pleura/pathology , Pleural Neoplasms/pathology , Pleural Neoplasms/secondary , Sarcoma, Ewing/drug therapy , Sarcoma, Ewing/pathology , Sarcoma, Ewing/physiopathology , Thoracic Wall/pathology , Tomography, X-Ray Computed/methods , Treatment Outcome
8.
Indian J Pathol Microbiol ; 2012 Oct-Dec 55(4): 569-571
Article in English | IMSEAR | ID: sea-145667

ABSTRACT

Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the prostate is extremely rare. Here, we report a case of ES/PNET of prostate in a 24-year-old man presenting with dysuria and pelvic discomfort. Computed tomography scan revealed a heterogeneous mass involving the prostate without evidence of distant metastases. Histologically, the tumor was composed of small round blue cells strongly and diffusely positive for CD99 and epithelial markers. Fluorescence in situ hybridization confirmed rearrangement of the Ewing's sarcoma region on chromosome 22.


Subject(s)
Humans , Keratins/metabolism , Male , Neuroectodermal Tumors, Primitive, Peripheral/diagnosis , Neuroectodermal Tumors, Primitive, Peripheral/epidemiology , Neuroectodermal Tumors, Primitive, Peripheral/pathology , Prostate , Review Literature as Topic , Sarcoma, Ewing/diagnosis , Sarcoma, Ewing/epidemiology , Sarcoma, Ewing/pathology , Tomography, X-Ray Computed , Young Adult
9.
Article in English | IMSEAR | ID: sea-157366

ABSTRACT

Ewing sarcoma is a rare malignant round cell tumor of the bone. It is the second most common primary malignant tumor of bone found in children. It commonly affects long bones, pelvis and ribs. An 11 year old boy presented with painful swelling at the medial end of left clavicle. X-ray revealed a diaphyseal lesion of the medial end of the left clavicle with destruction of bone and mottled appearance. FNAC was done and reported as Malignant round cell tumor suggestive of Ewing sarcoma. Histopathologically the diagnosis of Ewing sarcoma was confirmed with special stains. Ewing sarcoma affecting clavicle is uncommon. Clavicle can be often resected with no need of reconstruction in young children.


Subject(s)
Child , Clavicle/pathology , Humans , Male , Sarcoma, Ewing/cytology , Sarcoma, Ewing/diagnosis , Sarcoma, Ewing/pathology , Sarcoma, Ewing/diagnostic imaging
10.
Bol. Acad. Nac. Med. B.Aires ; 89(2): 199-207, jul.-dic. 2011.
Article in Spanish | LILACS | ID: lil-689093

ABSTRACT

La existencia de un grupo distintivo de neoplasias de células redondas de hueso y partes blandas altamente malignas fue reconocida desde el siglo pasado. Este grupo de tumores de células redondas y pequeñas comprenden un conjunto heterogéneo de neoplasias pobremente diferenciadas formadas por células pequeñas, redondas u ovales con alto índice nuclear-citoplasmático, núcleos redondos con cromatina dispersa o agrupada y nucléolo poco evidente. En el año 1921, James Ewing, profesor de Patología de la Universidad de Cornell, USA, describió estas características histológicas en un tumor que denominó endotelioma difuso de hueso. Charles Oberling, en Paris, en el año 1928, denominó la neoplasia como Sarcoma de Ewing. De manera resumida podemos plantear la evolución de las técnicas diagnósticas aplicadas en el estudio de la siguiente forma: 1) Aplicacion de técnicas convencionales histológicas: H&E. 2) Histoquímica convencional: PAS, Carmin de Best. 3) Microscopía Electrónica. 4) Inmunohistoquímica: marcadores mesenquimales, neurales, epiteliales y otros. 5) Cultivos celulares. 6) Xenotrasplante de tumores. 7) Estudios citogenéticos convencionales: traslocaciones cromosómicas principales. 8) FISH. 9) Biología molecular: reordenamiento genético y tipos de genes de fusión. Se presenta una visión global de los distintos aspectos de la morfología, ultra estructura inmunohistoquímica, genética convencional y molecular asi como nuevas aproximaciones a la terapéutica de este tumor óseo.


Subject(s)
Sarcoma, Ewing/classification , Sarcoma, Ewing/diagnosis , Sarcoma, Ewing/pathology , Sarcoma, Ewing/therapy , Academies and Institutes , Histology , Immunohistochemistry , Pathology , Pathology, Molecular , Histological Techniques/methods
11.
Indian J Pathol Microbiol ; 2011 Oct-Dec 54(4): 803-805
Article in English | IMSEAR | ID: sea-142117

ABSTRACT

Congenital extraskeletal Ewing's sarcoma or peripheral primitive neuroectodermal tumor is an extremely uncommon and invariably fatal tumor. We report a case of extraskeletal congenital Ewing's sarcoma in a female fetus delivered at 34 weeks of gestation who died immediately after birth. In English literature, majority of cases of Ewing's sarcoma in neonates reported were skeletal. To the best of our knowledge, very few cases of extra-skeletal Ewing's sarcoma in neonates are reported in the literature.


Subject(s)
Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Fatal Outcome , Female , Fetus , Humans , Infant, Newborn , Pregnancy , Sarcoma, Ewing/diagnosis , Sarcoma, Ewing/pathology , Thoracic Wall/pathology , Young Adult
12.
Rev. venez. oncol ; 23(3): 175-183, jul.-sept. 2011.
Article in Spanish | LILACS | ID: lil-618745

ABSTRACT

Precisar la importancia de realizar el estudio de inmunohistoquímica y su correlación con el diagnóstico anatomopatológico de rutina para el diagnóstico de los tumores sólidos malignos de células redondas en pacientes pediátricos. Se realizó un estudio transversal, descriptivo, retrospectivo no experimental. Se estudiaron 147 pacientes con diagnóstico de neoplasia de células redondas, de los cuales 96 cumplieron con criterios de inclusión. La mayor frecuencia de casos la obtuvo el linfoma No Hodgkin (20,8%), seguido del linfoma de Hodgkin (15,6%) y tumor de Wilms (17,7%). El grupo etario mayormente afectado fue el escolar (37,5%). El género predominante fue el masculino (60,4%). Las manifestaciones clínicas más frecuentes fueron masa palpable (76,04%), fiebre(44,79%), anemia (41,67%), dolor (41,30%) y pérdida de peso (33,33%). Se evidenció la mayor correlación diagnóstica en el tumor de Wilms (100%), seguido del linfoma No Hodgkin (80%) y el linfoma de Hodgkin (75%); la menor correlación la presentaron el sarcoma de Ewingy el neuroblastoma (41,7%, ambos). La correlación total resultó “considerable” según la fuerza de concordancia del coeficiente de Kappa (k: 0,601. P=0,000). Se requiere la integración del examen histopatológico de rutina como método diagnóstico de pesquisa y del estudio de inmunohistoquímica como método auxiliar diagnóstico, para determinar la histogénesis de las neoplasias, descartar diagnósticos diferenciales, realizar un diseño terapéutico apropiado y precisar el pronóstico.


To precise the state and the importance o fthe study of immunohistochemistry and its correlation with the routine pathological diagnosis to use in diagnosis of malignant solid tumors of round cells in pediatric patients. We was performed a transversal, descriptive and retrospective non-experimental study. We studied 147 patients diagnosed with round cell tumor, 96 of them weremet in inclusion criteria. The highest frequency of the cases was Non-Hodgkin lymphoma (20.8%), followed by the Hodgkin lymphoma (15.6%) and the Wilms tumor(17.7%). The age group most affected was the school(37.5%). The male gender was the predominant (60.4%).The most frequent clinical manifestations were a palpablemass (76.04%), the fever (44.79%), the anemia (41.67%),the pain (41.30%) and the weight loss (33.33%). Evidencedthe highest correlation in the diagnosis of Wilms tumor(100%), followed by Non-Hodgkin lymphoma (80%) and Hodgkin lymphoma (75%); showed the lowest correlation between the Ewing sarcoma and neuroblastoma (41.7%, both). The total correlation is “considerable” accordingto strength of agreement the Kappa coefficient (k: 0.601.P=0.000). It requires the integration of routine histopathological examination as diagnostic method of research and study of immunohistochemistry as an auxiliary diagnostic method to determine the histogenesis of neoplasm and exclude the differential diagnoses, make anappropriate therapeutic design and the determine prognosis of this group of patients.


Subject(s)
Humans , Male , Adolescent , Female , Infant , Child, Preschool , Child , Hodgkin Disease/pathology , Immunohistochemistry/methods , Lymphoma, Non-Hodgkin/pathology , Sarcoma, Ewing/pathology , Wilms Tumor/immunology , Wilms Tumor/drug therapy , Histocytochemistry , Burkitt Lymphoma/pathology , Medulloblastoma/pathology , Osteosarcoma
13.
Braz. dent. j ; 21(1): 74-79, Jan. 2010. ilus, tab
Article in English | LILACS | ID: lil-552357

ABSTRACT

Ewing's sarcoma (ES) is a malignancy primarily affecting bone tissue that is commonly diagnosed in adolescents and young adults. Its occurrence in the head and neck region is unusual and generally involves the mandible and maxilla. An extensive review of the literature shows only few cases of the oral ES in patients under the age of 5. This paper reports a rare case of ES of the mandible in a 4-year-old girl, which had been previously misdiagnosed and treated as a dental abscess. In the clinical examination, a hard immobile expansive mass of 5 cm in diameter was observed on the left side of the mandible. Radiographic examination revealed a radiolucent lesion with ill-defined borders and wide vestibular bone plate destruction. Microscopically, the tumor was composed by monotonous small round cells that exhibited immunoreactivity for CD99, vimentin and pancytokeratin. The patient was subjected to multiagent chemotherapy with ifosfamide, carboplatin, etoposide, vincristine, cyclophosfamide and doxorrubycin (VAC/ICE regimen). However, after the first chemotherapeutic cycle, the patient died due to disseminated infection. This case elucidates the importance of professional knowledge of the relevant aspects of malignant lesions such as ES.


O sarcoma de Ewing é um tumor maligno primário do osso, comumente diagnosticado em adolescentes e adultos jovens. Sua ocorrência na região de cabeça e pescoço não é usual, e geralmente ocorre em maxila ou mandíbula. Após revisão extensiva da literatura, poucos casos foram identificados acometendo pacientes com menos de 5 anos de idade. Nós relatamos um caso raro de SE em uma criança de 4 anos de idade que foi previamente diagnosticada e tratada como abscesso dentoalveolar. Ao exame clínico, uma massa expansiva endurecida e imóvel de 5 cm de diâmetro foi observada no lado esquerdo da mandíbula. O exame radiográfico mostrou lesão radiolúcida, com bordas mal definidas e ampla destruição da tábua óssea vestibular. Microscopicamente, o tumor era composto por células pequenas e arredondadas que exibiam imunorreatividade para CD99, vimentina e pancitoqueratina. O paciente foi submetido à quimioterapia com ifosfamida, carboplatina, e etoposide além de vincristina, ciclofosfamida e doxorrubicina (regime VAC/IE). Entretanto, após o primeiro ciclo da quimioterapia, o paciente foi a óbito por infecção disseminada. Este caso salienta a importância do conhecimento profissional no diagnóstico de tumores malígnas tais como o SE.


Subject(s)
Child, Preschool , Female , Humans , Mandibular Neoplasms/diagnosis , Sarcoma, Ewing/diagnosis , Abscess/diagnosis , Antigens, CD/analysis , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cell Adhesion Molecules/analysis , Diagnostic Errors , Fatal Outcome , Keratins/analysis , Mandibular Neoplasms/pathology , Sarcoma, Ewing/pathology , Tomography, X-Ray Computed , Tooth Diseases/diagnosis , Vimentin/analysis
14.
Rev. venez. oncol ; 21(4): 240-243, oct.-dic. 2009.
Article in Spanish | LILACS | ID: lil-571105

ABSTRACT

El sarcoma de Ewing o también llamado tumor neuroectodérmico primitivo es una entidad muy rara, cuyo diagnóstico se realiza con la utilización de estudios de inmunohistoquímica, su comportamiento es muy agresivo con una supervivencia limitada. Se presenta el caso de un paciente masculino de 18 años de edad que consultó por presentar un tumor renal, se le realizó nefrectomía radical con diagnóstico definitivo de sarcoma de Ewing extra esquelético. Esta es una patología quirúrgica poco frecuente, lo que nos motivó a su presentación y a la revisión de la literatura.


The Ewing sarcoma is also denominated primitive neuroectodermic tumor and is considered how a rare entity, the diagnostic is realize with the utilization of immunohistochemestry study’s, his clinical curse is very aggressive with a limite superlife. We presented and study a clinical case of a sex male patient of 18 years old which consult us for present a renal tumor. He underwent a radical nefrectomy with a definitive diagnostic of extra osseous Ewing sarcoma. This is a less frequent surgical pathology, we motive us to present and review the literature.


Subject(s)
Humans , Male , Adult , Immunohistochemistry/methods , Nephrectomy/methods , Kidney Neoplasms/surgery , Kidney Neoplasms/pathology , Neuroectodermal Tumors, Primitive/pathology , Medical Oncology , Sarcoma, Ewing/pathology
15.
Col. med. estado Táchira ; 18(1): 24-26, ene.-mar. 2009.
Article in Spanish | LILACS | ID: lil-530716

ABSTRACT

Los tumores óseos primitivos son neoplasias que se originan en el hueso, siendo los mas comunes en la infancia el osteosarcoma y el sarcoma de Ewing (aproximadamente 5% del total), aparecen en la segunda década de la vida son excepcionales antes de los 5 años de edad y es mas frecuente en el sexo masculino. Se presenta el caso de un escolar masculino de 6 años que inició enfermedad actual de 25 días de evolución caracterizada por dolor de fuerte intensidad a nivel de miembro inferior izquierdo que no mejora con la administración de analgésicos, posteriormente presenta aumento de volumen, e imposibilidad para la marcha. Asimetria de miembros inferiores dada por aumento de volumen de pierna izquierda con respecto a la derecha con 3 cm. de diferencia, dolorosa a la movilización. Rx de miembro inferior izquierdo: Levantamiento del periostio en tercio medio de peroné izquierdo. RMN de miembro inferior izquierdo se evidencia LOE en diáfisis de peroné izquierdo con infiltración de masa muscular. Se realizó exéresis del TU y tejidos adyacentes. La biopsia confirma el diagnóstico de sarcoma de Ewing con compromiso de partes blandas adyacentes y bordes libres de resección ósea libres de neoplasia. Recibió quimioterapia adyuvante. Finalizó tratamiento en Octubre del 2007. Actualmente Vivo sin enfermedad con excelente evolución pos-tratamiento y en seguimiento. El Sarcoma de Ewing es poco frecuente en menores de 10 años de edad, el pronóstico depende del tamaño, localización, metástasis al diagnóstico, niveles de LDH y respuesta a la quimioterapia inicial, debe individualizarse el tratamiento con el fin de lograr control local y erradicación de la enfermedad residual.


Subject(s)
Humans , Male , Child , Bone Neoplasms/surgery , Bone Neoplasms/pathology , Bone Neoplasms/drug therapy , Osteosarcoma , Fibula/anatomy & histology , Fibula/injuries , Biopsy/methods , Sarcoma, Ewing/surgery , Sarcoma, Ewing/pathology , Sarcoma, Ewing/drug therapy , Leg Injuries/etiology
16.
J Cancer Res Ther ; 2008 Jul-Sep; 4(3): 137-9
Article in English | IMSEAR | ID: sea-111561

ABSTRACT

An eleven-year-old boy presented with a swelling in his left elbow. Radiologically the features were that of an Ewing's sarcoma involving the ulna. Histopathology showed small round cell tumor strongly positive for Monoclonal Imperial Cancer research fund 2 (MIC2) antigen. Similar cells in the bone marrow were involved with MIC2 positivity. The patient developed skin lesions, which on biopsy were found to be chloromas. The initial biopsies were reevaluated with special stains revealing granulocytic sarcomas in acute myeloid leukemia masquerading as Ewing's due to its MIC2 positivity. The possibility of myeloid neoplasms should be considered routinely with known MIC2 positive round cell tumors.


Subject(s)
Child , Diagnosis, Differential , Elbow/pathology , Flow Cytometry , Humans , Leukemia, Myeloid, Acute/metabolism , Male , Sarcoma, Ewing/pathology , Sarcoma, Myeloid/metabolism , Biomarkers, Tumor/analysis
17.
Article in English | IMSEAR | ID: sea-51412

ABSTRACT

Ewing's sarcoma is an uncommon malignancy that occurs usually in childhood. In most reported cases, the occurrence of this tumor is more in the mandible than the maxilla. A case of Ewing's sarcoma of the maxilla together with its associated structures is presented and discussed with complete clinical, radiographic, and histological evaluation. Although the prognosis remains poor, an increased rate of survival is now associated with early diagnosis and combined therapy.


Subject(s)
Adolescent , Humans , Male , Maxillary Neoplasms/pathology , Radiography, Panoramic , Sarcoma, Ewing/pathology , Tomography, X-Ray Computed
18.
Biomedica. 2007; 23 (January-June): 8-11
in English | IMEMR | ID: emr-135829

ABSTRACT

In this study a total of 14 patients of paediatric age group were included with round cell tumours of Retinoblastoma, Neuroblastoma, Ewings's sarcoma and Rhabdomyosarcoma. The frequency of metastatic involvement of the bone marrow was determined by aspiration and biopsy from posterior iliac crest. Routine investigations like haemoglobin, total leukocyte count and, platelets count were also carried out in all cases. Results show that the neuroblastoma was most common to metastasize to bone marrow. It was also noted that, aspirate and biopsy were found complementary in diagnosis of metastasis. However further work is needed to find out the frequency of metastatic involvement of bone marrow in a larger series of cases


Subject(s)
Humans , Male , Female , Bone Neoplasms/secondary , Neoplasm Invasiveness , Neoplasm Metastasis , Pediatrics , Retinoblastoma/pathology , Neuroblastoma/pathology , Sarcoma, Ewing/pathology , Rhabdomyosarcoma/pathology , Bone Marrow
20.
Indian J Dermatol Venereol Leprol ; 2005 Nov-Dec; 71(6): 423-5
Article in English | IMSEAR | ID: sea-53120

ABSTRACT

Ewing's sarcoma (ES) is a small round cell tumor, usually arising from flat bones and diaphyseal region of long bones. It is commonly found in the first two decades of life. It is curable when diagnosed in the localized stage and requires multimodality treatment. ES is a chemosensitive tumor. It metastasizes commonly to lung, pleura and other bones. Less common sites of metastasis are lymph nodes, CNS and liver. Skin metastasis is extremely uncommon. It occurs in up to 9% of all patients with cancer. Growth pattern of cutaneous metastasis is unpredictable and may not reflect that of primary tumor. We hereby report three cases of Ewing's sarcoma that developed skin metastasis.


Subject(s)
Adolescent , Adult , Bone Neoplasms/secondary , Child , Fatal Outcome , Female , Humans , Male , Sarcoma, Ewing/pathology , Skin Neoplasms/secondary
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