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Article in English | WPRIM | ID: wpr-150736

ABSTRACT

Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Carcinoma/pathology , Carcinoma/metabolism , Carcinoma/chemistry , Eyelid Neoplasms/pathology , Eyelid Neoplasms/metabolism , Eyelid Neoplasms/chemistry , Immunohistochemistry , Middle Aged , Necrosis , Receptor, ErbB-2/biosynthesis , Receptor, ErbB-2/analysis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Sebaceous Gland Neoplasms/pathology , Sebaceous Gland Neoplasms/metabolism , Sebaceous Gland Neoplasms/chemistry
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