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Indian J Exp Biol ; 1993 Jul; 31(7): 587-9
Article in English | IMSEAR | ID: sea-59890


Hypothyroidism (surgical thyroidectomy) inhibited the activities of acid phosphatase and Mg(2+)-ATPase in seminal vesicular tissue and fluid and that of Ca(2+)- and Na+/K(+)-ATPases in fluid alone, and T4 supplementation restored normalcy in all, except acid phosphatase. Hyperthyroidism (T4 25 micrograms/100g body weight/day for 60 days, im) enhanced the activities of alkaline phosphatase and ATPases in seminal vesicular tissue and fluid, and decreased acid phosphatase activity in tissue alone. Withdrawal of T4 treatment from hyperthyroid rats (after 30 days) augmented the activity of ATPases in tissue and impaired the same in fluid, while phosphomonoesterases remained at hyperthyroid level. The results suggest specific responses of various seminal vesicular phosphatases to altered thyroid hormone status. Modification in the specific threshold of androgen/estrogen action on different phosphatases in seminal vesicles appears to be the plausible mechanism underlying these changes in hypo- and hyperthyroid conditions.

Adenosine Triphosphatases/metabolism , Albinism/enzymology , Animals , Ca(2+) Mg(2+)-ATPase/metabolism , Calcium-Transporting ATPases/metabolism , Hyperthyroidism/enzymology , Hypothyroidism/enzymology , Male , Phosphoric Monoester Hydrolases/metabolism , Rats , Rats, Wistar , Seminal Vesicles/enzymology , Sodium-Potassium-Exchanging ATPase/metabolism
Indian J Exp Biol ; 1991 Mar; 29(3): 205-7
Article in English | IMSEAR | ID: sea-62639


Impact of thyroidectomy (hypothyroidism) on few glycosidases was studied in the seminal vesicles of young albino rats. Thyroidectomy was performed at 30 days post partum. Seminal vesicular beta-D-glucosidase, beta-D-galactosidase, and N-acetyl-beta-D-galactosaminidase exhibited a similar response of decreased activities under short- (30 days) and long-term (60 days) hypothyroid conditions. On the other hand, N-acetyl-beta-D-glucosaminidase registered a temporal biphasic response of increased and decreased activities in the seminal vesicles of rats subjected to short- and long-term hypothyroidism, respectively. The data obtained in the present study suggest that thyroid hormones have specific influences on different glycosidases in the seminal vesicles of rats and euthyroid status is essential for the maintenance of normal activities of these enzymes.

Animals , Glycoside Hydrolases/metabolism , Male , Rats , Rats, Inbred Strains , Seminal Vesicles/enzymology , Thyroid Gland/physiology , Thyroidectomy
Indian J Exp Biol ; 1990 Dec; 28(12): 1128-31
Article in English | IMSEAR | ID: sea-56275


E ects of prolactin (PRL), bromocriptine (Br), testosterone propionate (TP), dihydrotestosterone (DHT) and the combinations of these androgens with PRL/Br on specific activities of adenosine triphosphatases (ATPases) of seminal vesicles and cranial and caudal prostates were studied in castrated adult bonnet monkeys. Castration decreased all ATPases (sodium/potassium, magnesium and calcium dependent) of seminal vesicles and both the lobes of prostate. PRL restored the normal activities of all ATPases in both the organs. Br given alone decreased all ATPases of prostate but caused no significant alteration, particularly calcium dependent ATPases of seminal vesicles and caudal prostate. TP/DHT replacement restored all ATPases of both the organs to the normal levels. PRL + TP/DHT further enhanced all the ATPases activities of all the regions studied. Br + TP/DHT decreased all ATPases but it did not produce any alteration in the calcium ATPases of seminal vesicles. The results suggest that prolactin facilitates membrane transport enzymes in the cranial and caudal prostate and seminal vesicles of adult castrated bonnet monkeys.

Adenosine Triphosphatases/metabolism , Animals , Bromocriptine/pharmacology , Dihydrotestosterone/pharmacology , Macaca radiata , Male , Orchiectomy , Prolactin/physiology , Prostate/enzymology , Seminal Vesicles/enzymology , Testosterone/physiology
Indian J Physiol Pharmacol ; 1985 Jan-Mar; 29(1): 1-6
Article in English | IMSEAR | ID: sea-107512


Studies on the distribution of Na+, K+-dependent, Mg2+ dependent and Ca2+ dependent Adenosine Triphosphatase (ATP-ases) in the testes, epididymis, seminal vesicles and prostate glands of mature bonnet monkeys were carried out with and without Testosterone propionate (TP) treatment. Comparatively, the Ca2+ dependent ATP-ase was very active in the testes, caput and cauda epididymis and prostate of control animals. However, the Mg2+-dependent ATP-ase activity was predominant in the seminal vesicles. In all the genital tissues the Na+, K+ dependent ATP-ase exhibited low activity compared to other ATP-ase systems. On TP treatment at 1 mg/kg body wt. dose for 30 consecutive days to the second group of animals, all classes of ATP-ases drastically decreased in the testes, cauda epididymis, seminal vesicles and prostate. While in caput epididymis the Mg2+-dependent ATP-ase was stimulated, the Na+, K+-dependent ATP-ase was decreased both in the caput and corpus epididymis by the hormone treatment. The present study reveals the general inhibitory influence on the ATP-ase systems and thereby ionic transport after long term TP administration.

Adenosine Triphosphatases/antagonists & inhibitors , Animals , Ca(2+) Mg(2+)-ATPase/antagonists & inhibitors , Calcium-Transporting ATPases/antagonists & inhibitors , Epididymis/enzymology , Genitalia, Male/drug effects , Macaca radiata , Male , Prostate/enzymology , Seminal Vesicles/enzymology , Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors , Testis/enzymology , Testosterone/pharmacology