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Arq. bras. cardiol ; 112(2): 121-128, Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-983822


Abstract Background: Obesity is associated with an increased risk of type 2 diabetes mellitus (DM), ischemic heart disease (IHD) and cardiovascular mortality. Several studies have demonstrated the diagnostic and prognostic value of single photon computed tomography-myocardial perfusion scintigraphy (SPECT-MPI) in the evaluation of patients with suspected IHD, including in obese population. Data on clinical risk factors and their association with abnormal myocardial perfusion in obese patients are scarce in the Brazilian population. Objective: To determine the factors associated with abnormal myocardial perfusion in obese individuals without known IHD. Methods: We studied obese patients without known IHD who were referred for evaluation through SPECT-MPI between January 2011 and December 2016. Clinical variables and results of SPECT-MPI were obtained systematically. The distribution of continuous variables was assessed using the Shapiro-Wilk and Shapiro-Francia tests. We used the unpaired Student t test to compare the means of continuous variables with normal distribution and the Chi Square test for binomial variables analysis. A p value < 0.05 was considered statistically significant. The association of the clinical variables for the presence of factors associated with abnormal myocardial perfusion was determined by univariate and multivariate logistic regression analysis, and respective odds ratios (OR) and 95% confidence intervals (CI). Results: The study sample consisted of 5,526 obese patients. Mean body mass index (BMI) of our patients was 33.9 ± 3.7 kg/m2, 31% had DM, and myocardial perfusion abnormalities was observed in 23% of the total sample. The factors associated with abnormal myocardial perfusion on multivariate analysis were: age (OR: 1.02, 95% CI 1.01-1.03, p < 0.001), DM (OR: 1.57, 95% CI 1.31-1.88, p < 0.001), typical angina before the test (OR: 2.45, 95% CI: 1.82-3.31, p < 0.001), need for pharmacologic stress test (OR: 1.61, 95% CI: 1.26-2.07, p < 0.001), less physical effort evaluated in metabolic equivalents (METs) during the exercise treadmill test (OR: 0.89, 95% CI: 0.85-0.94, p < 0.001) and a lower post-stress left ventricular ejection fraction after stress (LVEF; OR: 0.989, 95% CI: 0.984-0.994, p < 0.001). Conclusion: The factors associated with abnormal myocardial perfusion in obese patients without known IHD were age, DM, presence of typical angina, ventricular dysfunction, and inability to undergo physical stress as clinical variables, in addition to functional capacity during physical stress.

Resumo Fundamento: A obesidade associa-se a um risco aumentado de diabetes mellitus do tipo 2 (DM), doença cardíaca isquêmica (DCI) e mortalidade cardiovascular. Vários estudos demonstraram o valor diagnóstico e prognóstico da cintilografia de perfusão miocárdica com tomografia computadorizada por fóton único (CPM-SPECT) na avaliação de pacientes com suspeita de DCI, inclusive na população de obesos. Dados sobre fatores de risco clínicos, e sua associação com perfusão miocárdica anormal em obesos, são escassos na população brasileira. Objetivo: Determinar quais são os fatores associados à anormalidade de perfusão miocárdica em obesos sem DCI conhecida. Métodos: Estudamos pacientes obesos sem DCI conhecida que foram encaminhados para avaliação por CPM-SPECT entre janeiro de 2011 até dezembro de 2016. Variáveis clínicas e resultados da CPM-SPECT foram obtidos de forma sistematizada. A distribuição das variáveis contínuas foi avaliada utilizando-se os testes de Shapiro-Wilk e Shapiro-Francia. Utilizou-se o teste t de Student não pareado para comparar as médias das variáveis contínuas com distribuição normal, e o teste do Chi quadrado para análise das variáveis binomiais. Considerou-se o valor de p < 0,05 como estatisticamente significativo. A associação das variáveis clínicas para a presença de anormalidade de perfusão miocárdica foi determinada por análise de regressão logística univariada e multivariada, calculando-se e apresentando-se os respectivos odds ratios (OR) e intervalos de confiança (IC) de 95. Resultados: A amostra do estudo foi de 5.526 pacientes obesos. O índice de massa corporal médio dos nossos pacientes foi de 33,9 ± 3,7 kg/m2, 31% eram portadores de DM, e anormalidades de perfusão foram observadas em 23% do total da amostra. Os fatores associados à anormalidade de perfusão miocárdica, após análise multivariada, foram: idade (OR: 1,02, IC 95%: 1,01-1,03, p < 0,001), DM (OR: 1,57, IC 95%: 1,31-1,88, p < 0,001), presença de angina típica antes do exame (OR: 2,45, IC 95%: 1,82-3,31, p < 0,001), necessidade de utilização de protocolo com estresse farmacológico (OR: 1,61, IC 95%: 1,26-2,07, p < 0,001), menor esforço físico avaliado em equivalentes metabólicos durante o teste ergométrico (OR: 0,89, IC 95%: 0,85-0,94, p < 0,001) e menor fração de ejeção do ventrículo esquerdo após estresse (OR: 0,989, IC 95%: 0,984-0,994, p < 0,001). Conclusão: Os fatores associados à anormalidade de perfusão miocárdica em pacientes obesos sem DCI conhecida foram idade, DM, presença de angina típica, disfunção ventricular e incapacidade para o estresse físico como variáveis clínicas, além da capacidade funcional durante o estresse físico.

Humans , Male , Female , Adult , Middle Aged , Aged , Myocardial Ischemia/physiopathology , Heart/physiology , Myocardium , Obesity/physiopathology , Reference Values , Stroke Volume/physiology , Body Mass Index , Logistic Models , Sex Factors , Predictive Value of Tests , Prospective Studies , Risk Factors , Ventricular Function, Left/physiology , Statistics, Nonparametric , Risk Assessment/methods , Myocardial Perfusion Imaging/methods , Single Photon Emission Computed Tomography Computed Tomography/methods , Heart/diagnostic imaging
LMJ-Lebanese Medical Journal. 2018; 66 (1): 10-15
in English | IMEMR | ID: emr-170968


Objectives: The purpose of this study was to compare SPECT/CT and planar lymphoscintigraphy in detecting hot nodes

Methods: In this retrospective study, planar and SPECT/CT lymphoscintigraphy were performed in 119 consecutive women with invasive breast cancer. Both images were assessed for the number of lymph nodes and their anatomical site. Hot nodes were categorized based on the classification used by surgeons as level I, II, III nodes. In addition, pathology reports were retrieved which provided additional information concerning the characteristics of the lesions missed or detected by either or both imaging modalities

Results: SPECT/CT detected hot nodes in 81 [68%] patients, while planar lymphoscintigraphy detected hot nodes in 70 [58.8%] patients. SPECT/ CT and planar imaging had 38 [32%] patients in common where they did not detect any hot nodes. According to histopathology, 15 [12.6%] out of 36 patients with negative lymphoscintigraphic sentinel node identification on both modalities had nodal metastasis. The higher lymph node detection rate by SPECT/CT was significant [p = 0.019]

Conclusion: When compared to planar lymphoscintigraphy, SPECT/CT refines preoperative lymph node detection and thus [N] staging. As such, we recommend that SPECT/CT ought to be performed in a particular set of patients, for it improves localization of the draining nodes, detects nodes missed on planar, and excludes false positives in cases of lymphatic/blood vessel radiotracer accumulation

Humans , Female , Sentinel Lymph Node/diagnostic imaging , Single Photon Emission Computed Tomography Computed Tomography , Retrospective Studies , Lymphoscintigraphy
Arch. endocrinol. metab. (Online) ; 61(3): 288-290, May-June 2017. graf
Article in English | LILACS | ID: biblio-887560


SUMMARY The whole-body iodine-131 scintigraphy is an imaging technique in monitoring patients with a history of thyroid cancer. Although the rate of false positives is negligible, it is not nonexistent. We report the case of an intervened and treated patient for thyroid cancer with good clinical and biochemical response. Scintigraphic findings were consistent with unsuspected bone metastasis. Fused SPECT/CT data allowed accurate diagnosis of giant diaphragmatic hernia associated with intrathoracic stomach, a very rare pathology that can lead to false positive results.

Humans , Female , Aged , Bone Neoplasms/secondary , Bone Neoplasms/diagnostic imaging , Carcinoma/pathology , Carcinoma/diagnostic imaging , Single Photon Emission Computed Tomography Computed Tomography/methods , Hernia, Diaphragmatic/diagnostic imaging , Stomach/diagnostic imaging , Thyroid Neoplasms/pathology , Thyroid Neoplasms/diagnostic imaging , Carcinoma, Papillary , Diagnosis, Differential , Whole Body Imaging , Thyroid Cancer, Papillary , Iodine Radioisotopes
Article in English | WPRIM | ID: wpr-633545


Bone scan is a sensitive imaging procedure for cancer patients who are at high risk for bone metastases. Despite the high sensitivity, Tc-99m methylene diphosphonate (MDP) is not a specific tracer and its increased uptake may also be seen in extra-osseous areas. In cases where localization of extra-osseous sites of MDP uptake on planar imaging prove to be difficult, single photon emission computed tomography with computed tomography (SPECT/CT) may be useful. A known lung cancer patient was referred for whole body bone scan to detect bone metastasis. Planar images showed tracer accumulation in the left area of the head, suspicious for skull metastasis. SPECT-CT imaging of the head was done for further evaluation, which showed Tc-99m MDP uptake in the left temporoparietal lobe. Magnetic resonance imaging (MRI) of the brain was subsequently done, which showed a subacute brain infarct corresponding to the Tc-99m MDP-avid focus. Thus, SPECT-CT was helpful in proper anatomical localization of the focal Tc-99m MDP uptake in the head, which otherwise might have been easily mistaken for skull metastasis should only planar imaging was used.

Humans , Male , Aged , Technetium Tc 99m Medronate , Single Photon Emission Computed Tomography Computed Tomography , Skull , Magnetic Resonance Imaging , Brain , Lung Neoplasms
Rev. otorrinolaringol. cir. cabeza cuello ; 75(2): 129-136, ago. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-757894


Introducción: En pacientes con rinosinusitis crónica (RSC) por fibrosis quística (FQ), los microorganismos que colonizan la vía aérea alta son los mismos que dañan el pulmón. Los tratamientos locales con nebulización de las cavidades perinasales (CPN) serían de ayuda. Objetivo: Evaluar la penetración de las partículas nebulizadas a las cavidades perinasales. Material y método: Voluntarios sanos y pacientes con RSC por FQ con cirugía endoscópica funcional (CEF). Se utilizó el nebulizador pulsátil que PARI LC SPRINT® SINUS. La penetración de partículas a las CPN se evaluó con fusión de imágenes cintigráficas SPECT y de tomografía computarizada (CT). Resultados: Se evaluaron 5 voluntarios y 2 pacientes con FQ. El procedimiento indicado por el fabricante del nebulizador fue imposible de realizar. Se modificó la forma de nebulización. Se observó solo el 9% del material nebulizado en las CPN en voluntarios y el 4% en pacientes. Una proporción importante del material nebulizado se depositó en pulmones y tubo digestivo. Conclusión: Los resultados iniciales motivaron la interrupción del estudio original considerando que sería difícil demostrar la diferencia en la efectividad del nebulizado para alcanzar las CPN entre pacientes con y sin CEF. Además, el depósito mayoritario del nebulizado fuera de las CPN, impide aclarar el valor del efecto local respecto a un posible efecto por vía general.

Introduction: In cystic fibrosis patients with chronic rhinosinusitis, the same microorganisms that colonize the upper airway are the ones who damage the lung. Local treatments by nebulization of perinasal sinuses would be helpful in these cases. Aim: To evaluate the penetration ability of nebulized particles into perinasal sinuses. Material and method: Healthy volunteers and cystic fibrosis patients with chronic rhinosinusitis with endoscopic sinus surgery had nasal nebulization using the pulsating nebulizer PARI LC Sprint® SINUS. Fusion of scintigraphic SPECT and CT images was used to evaluate the particles penetration ability into perinasal sinuses. Results: Five volunteers and 2 patients with CF were evaluated. It was not possible to perform the nebulization procedure as indicated by the manufacturer. A continous nebulization was done instead. 9% of the nebulized material was deposited in the perinasal sinuses in volunteers and 4% in patients with CF, while the rest of the particles were distributed in the body, specially in lungs and digestive tract. Conclusions: The main deposition of the nasal nebulized solution was outside the perinasal sinuses. These results led to discontinuation of the study because it would be difficult to prove a difference in the effectiveness of nebulized particles among patients with and without surgery. It also seems impossible to define the real value of local perinasal sinus therapies considering a probable systemic effect.

Humans , Male , Female , Middle Aged , Aged , Aerosols/administration & dosage , Nebulizers and Vaporizers , Paranasal Sinuses/drug effects , Administration, Inhalation , Nasal Cavity/drug effects , Pharmacokinetics , Postoperative Period , Prospective Studies , Rhinitis , Single Photon Emission Computed Tomography Computed Tomography , Sinusitis
Iranian Journal of Nuclear Medicine. 2012; 20 (1): 39-41
in English | IMEMR | ID: emr-155506


Parathyroid adenoma involving a single parathyroid gland is the underlying cause of 80-85% of primary hyperparathyroidism [PHPT]. Skeletal system is significantly affected by PHPT. Brown tumors are known to have affinity for [99m]Tc-MIBI. We report a rare case of PHPT presenting with diffuse bony pain, high calcium level and significantly elevated alkaline phosphatase level. [99m]Tc-pertechnetate/[99m]Tc-MIBI subtraction, performed as a part of routine protocol, showed several brown tumors showing affinity for both [99m]Tc-pertechnetate and [99m]Tc-MIBI. They were further characterized using hybrid SPECT/CT. To the best of our knowledge, [99m]Tc-pertechnetate affinity in brown tumors has not been previously described

Humans , Male , Adult , Adenoma , Sodium Pertechnetate Tc 99m , Hyperparathyroidism, Primary , Technetium Tc 99m Sestamibi , Single Photon Emission Computed Tomography Computed Tomography
Jordan Medical Journal. 2012; 46 (4): 375-380
in English | IMEMR | ID: emr-155533


Reconstruction of the anterior cruciate ligament [ACL] is one of the most frequently performed procedures in orthopaedics.1 Although most of the patients show a satisfactory outcome reflecting stable and pain free knees, some complain about persistent or recurrent instability or pain after ACL reconstruction.2 The state-of-the-art diagnostic follow-up in these patients includes a thorough history and clinical examination, blood work [CRP and leucocytes], joint aspiration or biopsies from a diagnostic arthroscopy, conventional radiographs [anterior-posterior and lateral weight bearing, tunnel view and skyline view of the patella], computerized tomography [CT], and magnetic resonance imaging [MRI]. To date, single photon emission tomography and combined conventional CT [SPECT/CT] was used only in a few cases.3,4 With this case, we strive to present the diagnostic work-up in a patient with pain after ACL reconstruction and introduce SPECT/CT as a new diagnostic imaging modality. Furthermore, the possible clinical value of SPECT/CT as new diagnostic imaging modality is highlighted

Humans , Young Adult , Pain, Postoperative/diagnosis , Single Photon Emission Computed Tomography Computed Tomography