Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 60
Filter
1.
Braz. j. otorhinolaryngol. (Impr.) ; 86(3): 281-286, May-June 2020. tab
Article in English | LILACS | ID: biblio-1132589

ABSTRACT

Abstract Introduction: Clinicians rely on clinical presentations to select therapeutic agents for acute bacterial rhinosinusitis. Streptococcus pneumoniae and Haemophilus influenzae are common in acute bacterial rhinosinusitis. Drug resistant Streptococcus pneumoniae and Haemophilus influenzae require different antibiotics. Objective: This study aimed to evaluate the associations between clinical features of acute bacterial rhinosinusitis and pathogenic bacteria. Methods: Sixty-four patients with acute bacterial rhinosinusitis were enrolled. Clinical features including nasal obstruction, discolored discharge, facial pain, smell disturbance, fever and laboratory findings of patients with acute bacterial rhinosinusitis were collected. The bacterial cultures of endoscopic middle meatal swabs were used as a reference. Results: Serum C-reactive protein level elevation correlated with the bacterial species (p = 0.03), by which was increased in 80.0% of Haemophilus influenzae rhinosinusitis and 57.1% of Streptococcus pneumoniae rhinosinusitis. The elevated C-reactive protein was the significant predictor for Haemophilus influenzae rhinosinusitis with the Odds Ratio of 18.06 (95% CI 2.36-138.20). The sensitivity of serum C-reactive protein level elevation for diagnosing Haemophilus influenzae rhinosinusitis was 0.80 (95% CI 0.49-0.94). Conclusion: Elevation of serum C-reactive protein level was associated with and predicted acute bacterial rhinosinusitis caused by Haemophilus influenzae.


Resumo: Introdução: Os médicos se baseiam nas características clínicas para a escolha dos agentes terapêuticos para o tratamento da rinossinusite bacteriana aguda. Streptococcus pneumoniae e Haemophilus influenzae são agentes comuns na rinossinusite bacteriana aguda. Streptococcus pneumoniae e Haemophilus influenzae resistentes a antibióticos requerem medicamentos diferentes. Objetivo: Avaliar as associações entre as características clínicas da rinossinusite bacteriana aguda e bactérias patogênicas. Método: O estudo incluiu 64 pacientes com rinossinusite bacteriana aguda. Foram coletadas e registradas as características clínicas, inclusive obstrução nasal, secreção com cor alterada, dor facial, distúrbios do olfato, febre e achados laboratoriais de pacientes com rinossinusite bacteriana aguda. As culturas bacterianas obtidas por swab endoscópico do meato médio foram usadas como referência. Resultados: A elevação do nível sérico de proteína C-reativa estava correlacionada com a espécie bacteriana (p = 0,03); ela estava aumentada em 80,0% das rinossinusites por Haemophilus influenzae e em 57,1% das rinossinusites por Streptococcus pneumoniae. A proteína C-reativa elevada foi um significativo fator preditor de rinossinusite por Haemophilus influenzae, com razão de probabilidade de 18,06 (IC 95% 2,36-138,20). A sensibilidade da elevação dos níveis séricos de proteína C-reativa para o diagnóstico de rinossinusite por Haemophilus influenzae foi de 0,80 (IC 95% 0,49 ± 0,94). Conclusão: A elevação dos níveis séricos de proteína C-reativa é um preditor de rinossinusite bacteriana aguda causada por Haemophilus influenzae.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Sinusitis/microbiology , Rhinitis/microbiology , Gram-Positive Bacterial Infections/microbiology , Gram-Negative Bacterial Infections/microbiology , Acute Disease , Cross-Sectional Studies
2.
Int. j interdiscip. dent. (Print) ; 13(1): 35-39, abr. 2020. graf
Article in Spanish | LILACS | ID: biblio-1114891

ABSTRACT

La cirugía de elevación de seno maxilar se considera como la técnica de aumento óseo más predecible. Sin embargo, no está exenta de complicaciones las cuales deben ser manejadas adecuadamente. Se presenta un caso clínico rehabilitado, con un seguimiento de 3 años, en el cual se realizó un manejo multidisciplinario y resolutivo de complicaciones asociadas a la técnica quirúrgica de elevación de membrana sinusal vía ventana lateral. Frente a una infección postoperatoria, como la presentada en el caso, hay que considerar iniciar un tratamiento antibiótico en el momento adecuado para impedir el agravamiento del cuadro clínico o un cambio de esquema en caso de resistencia antimicrobiana.


Maxillary sinus lift surgery is considered the most predictable bone augmentation technique. However, this procedure is not without complications, which must be handled properly. We present a rehabilitated clinical case, with a 3-year follow-up, in which a multidisciplinary and resolutive management of complications associated with the surgical technique of sinus lift procedure, using lateral window approach, was performed. In case of postoperative infection, such as the one presented in this report, it is necessary to consider starting an antibiotic treatment at the adequate moment to prevent the aggravation of the illness or change the pharmacological treatment in case of antimicrobial resistance.


Subject(s)
Humans , Female , Adult , Sinusitis/therapy , Bacterial Infections/therapy , Rhinitis/therapy , Sinus Floor Augmentation/adverse effects , Postoperative Complications/rehabilitation , Sinusitis/etiology , Sinusitis/microbiology , Bacterial Infections/etiology , Dental Implants , Rhinitis/etiology , Rhinitis/microbiology , Acute Disease , Follow-Up Studies , Treatment Outcome
3.
Rev. chil. infectol ; 37(1): 77-81, feb. 2020. graf
Article in Spanish | LILACS | ID: biblio-1092725

ABSTRACT

Resumen Los episodios de neutropenia febril son cuadros graves, que requieren un estudio etiológico exhaustivo y un inicio rápido de antimicrobianos. Dentro de los posibles microorganismos causales se encuentran los de origen fúngico, los que, dependiendo de su grado de invasión tisular, pueden llegar a presentar una alta mortalidad. Presentamos el caso de un niño con una leucemia mieloide aguda, que tras su quimioterapia de inducción, presentó un episodio de neutropenia febril, con una infección rino-sinusal por Exserohilum rostratum, hongo filamentoso que raramente se asocia a cuadros patológicos. Se inició rápidamente terapia antifúngica, lo cual, asociado a un aseo quirúrgico precoz, lograron una respuesta clínica favorable, sin complicaciones. Luego del seguimiento, y tras recibir profilaxis secundaria durante los episodios de neutropenia, no ha vuelto a presentar nuevas lesiones ni compromiso rino-sinusal.


Abstract The episodes of febrile neutropenia are severe cases that require an exhaustive etiological study and a quick start of antimicrobial agents. Within the possible microorganisms, fungal origins are also found, and depending on its tissue invasion, they can reach a high mortality rate. A case of a pediatric patient who suffered from acute myeloid leukemia is reported, and after his induction chemotherapy, the patient showed an episode of febrile neutropenia, which matches a rhinosinusal infection caused by Exserohilum rostratum, a filamentous fungi that is uncommonly associated with pathological cases. An antifungal therapy and an early surgical treatment were started, which lead to a positive response, without complications to the patient. After the monitoring and receiving secondary prophylaxis during the episodes of neutropenia, the patient hasn't presented new injuries nor rhinosinusal damage.


Subject(s)
Humans , Child , Ascomycota/isolation & purification , Sinusitis/complications , Sinusitis/microbiology , Sinusitis/drug therapy , Leukemia, Myeloid, Acute/complications , Mycoses/complications , Mycoses/drug therapy , Antifungal Agents/therapeutic use , Treatment Outcome , Neutropenia/etiology
4.
Rev. otorrinolaringol. cir. cabeza cuello ; 79(3): 366-373, set. 2019. graf
Article in Spanish | LILACS | ID: biblio-1058709

ABSTRACT

RESUMEN La rinosinusitis fúngica invasiva aguda (RSFIA) es una enfermedad poco frecuente caracterizada por una infiltración fúngica de la submucosa y vasos sanguíneos de las cavidades nasal y paranasal. Afecta a pacientes con grados variables de inmunosupresión, destacando entre estas patologías subyacentes la diabetes mellitus y las neoplasias malignas hematológicas. Presenta una alta tasa de mortalidad, pudiendo reducirse significativamente si el diagnóstico y el tratamiento se realizan precozmente. Este artículo tiene por objetivo presentar una revisión actualizada de la literatura respecto a la presentación clínica, microbiología, factores de riesgos, métodos diagnósticos, tratamiento y pronóstico de la RSFIA, tanto en adultos como en niños.


ABSTRACT Acute invasive fungal rhinosinusitis (AIFS) is a rare disease characterized by fungal infiltration of the submucosa and blood vessels of the nasal y paranasal cavities. It affects almost exclusively patients with different degrees of immunosuppression, with underlying pathologies such as diabetes mellitus and hematological malignancies. AIFS has a high mortality rate, but it can be significantly reduced if the diagnosis and treatment are carried out early in the course of disease. This article aims to present an updated literature review regarding clinical presentation, microbiology, risk factors, diagnostic methods, treatment and prognosis of AIFS, both in adults and children.


Subject(s)
Humans , Child , Adult , Sinusitis/diagnosis , Sinusitis/microbiology , Sinusitis/therapy , Rhinitis/diagnosis , Rhinitis/microbiology , Rhinitis/therapy , Prognosis , Acute Disease , Risk Factors , Immunocompromised Host , Debridement , Mycoses , Antifungal Agents/therapeutic use
5.
Int. arch. otorhinolaryngol. (Impr.) ; 23(2): 152-156, 2019. tab
Article in English | LILACS | ID: biblio-1010241

ABSTRACT

Introduction: A common practice in the management of patients with chronic rhinosinusitis (CRS), the empirical use of antibiotics may contribute to treatment failure and to the development of antimicrobial resistance. Objective: To determine the antibiotic sensitivity pattern of aerobic and anaerobic bacteria associated with CRS. Methods: This was a prospective cross-sectional study in which endoscopically guided middlemeatal swabs (IBMSpss, version 16.0, Chicago, IL, USA) were aseptically taken from patients diagnosed with CRS after obtaining informed consent and ethical clearance. The samples were sent to the laboratory for qualitative and semiquantitative analysis via gram stain, aerobic, anaerobic cultures and antibacterial sensitivity tests. The collected data was analyzed using SPSS for Windows, version 16 (SPSS Inc, Chicago, IL, USA). Simple statistical parameters and paired sample t-test were used, as appropriate. Results: There were 74 (56.92%) bacterial growths, out of which 55 (74.32%) were aerobic and 19 (25.68%) were anaerobic isolates, from a total of 130 patients. About 13 (17.5%- 18%) of these bacterial growths yielded a mixed growth of aerobic and anaerobic isolates. Themost common bacterial isolates were 26 (35.14%) Staphylococcus aureus, Haemophilus influenzae 9 (12.16%), Streptococcus viridians 8 (10.81%), and Streptococcus pneumoniae 5 (6.76%). Augmentin, ciprofloxacin, and Peflacine were found to bemost effective, followed by levofloxacin, Rocephin, erythromycin and Zinat in that order (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Bacteria, Anaerobic , Bacteria, Aerobic , Anti-Bacterial Agents/administration & dosage , Sinusitis/microbiology , Microbial Sensitivity Tests , Rhinitis/microbiology , Chronic Disease , Cross-Sectional Studies , Prospective Studies , Amoxicillin-Potassium Clavulanate Combination , Drug Resistance, Bacterial , Nigeria
6.
Arch. argent. pediatr ; 116(4): 594-598, ago. 2018. ilus, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-950049

ABSTRACT

La infección fúngica invasora ha aumentado en frecuencia a lo largo de la última década, y la sinusitis fúngica es cada vez más habitual. Los hongos del género Exserohilum (familia Pleosporaceae, orden Pleosporales) son filamentosos y dematiáceos, de localización ubicua. Se trata de patógenos emergentes, que producen, en la mayoría de los casos, infecciones sistémicas que afectan, principalmente, a los senos paranasales y los pulmones. Son más frecuentes en pacientes inmunosuprimidos, aunque pueden presentarse en pacientes inmunocompetentes. El tratamiento de estas infecciones comprende el tratamiento antifúngico, resección quirúrgica y restitución de la inmunidad. Se presenta el caso de una paciente con recaída medular de leucemia linfoblástica aguda con sinusitis fúngica invasiva por Exserohilum rostratum.


Invasive fungal infection has increased in frequency over the last decade, with fungal sinusitis becoming more frequent. The fungi of the genus Exserohilum (family Pleosporaceae, order Pleosporales) are filamentous and dematiaceous of ubiquitous location. It is an emerging pathogen, which in most cases produces a systemic infection that mainly affects the paranasal sinuses and lungs. It is more common in immunosuppressed patients, although it may occur in immunocompetent patients. The treatment is based on three pillars: antifungal treatment, surgical debridement and restitution of immunity. We present the case of a patient with medullary relapse of acute lymphoblastic leukemia with invasive fungal sinusitis by Exserohilum rostratum.


Subject(s)
Humans , Female , Child, Preschool , Ascomycota/isolation & purification , Sinusitis/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Invasive Fungal Infections/diagnosis , Recurrence , Sinusitis/microbiology , Sinusitis/therapy , Acute Disease , Debridement/methods , Invasive Fungal Infections/microbiology , Invasive Fungal Infections/therapy , Antifungal Agents/therapeutic use
8.
Braz. j. otorhinolaryngol. (Impr.) ; 80(6): 480-489, Nov-Dec/2014. tab, graf
Article in English | LILACS | ID: lil-730452

ABSTRACT

Introduction: For decades, animals have been used in sinonasal experimental models, and the practice has increased substantially in the last few years. This study aimed to assess the pathogenesis of infectious process and medication efficiency to treat rhinosinusitis. Objective: To evaluate the efficiency of the proposed experimental model to induce an acute bacterial sinonasal infectious process through histological analysis and sinus secretion cultures. Methods: This was an experimental study with 22 New Zealand rabbits, divided into: group A (six rabbits), group B (seven rabbits), group C (seven rabbits), and group D (control group with two rabbits). Rhinosinusitis was induced by the insertion of a synthetic sponge into the right nasal cavity of 20 animals (study groups), followed by the instillation of bacterial strains (50% Staphylococcus sp. and 50% Streptococcus sp.). The groups were euthanized within 10 days (group A), 17 days (group B), and 30 days (groups C and D). Results: All the rabbits of the study group developed acute bacterial rhinosinusitis, which was diagnosed through macroscopic evaluation, histological analysis, and sinus secretion culture. Conclusion: The proposed model is technically simple to perform, it is similar to the rhinogenic model in human beings, and it is highly efficient to reproduce an acute bacterial sinus infection. .


Introdução: A realização de modelos experimentais nasossinusais em animais vem sendo realizada há décadas, com substancial aumento nos últimos anos. Tem como objetivos identificar as alterações fisiopatológicas ocasionadas pelo processo infeccioso sinusal e avaliar a eficácia de medicamentos no tratamento da rinossinusite. Objetivo: Avaliar a eficácia do modelo experimental proposto para a indução de um processo infeccioso nasossinusal agudo bacteriano, utilizando parâmetros histopatológicos e cultura da secreção sinusal. Método: Estudo experimental com 22 coelhos da raça Nova Zelândia, divididos em: grupo A (6 coelhos), grupo B (7 coelhos), grupo C (7 coelhos) e grupo D (controle com 2 coelhos).Induzido quadro de rinossinusite através da inserção de esponja sintética nas fossas nasais direita dos 20 coelhos (grupos de estudo), seguido por instilação de toxoide bacteriano (50% estreptocócico, 50% estafilocócico). Os grupos foram sacrificados com 10 dias (grupo A), 17 dias (grupo B) e 30 dias (grupos C e D). Resultados: Todos os coelhos do grupo de estudo apresentaram quadro de rinossinusite aguda bacteriana, através da identificação macroscópica, análise histológica e cultura das secreções. Conclusão: O modelo proposto apresenta simplicidade técnica para sua execução, similaridade ao quadro rinogênico que acomete os humanos e é altamente eficaz na produção de um quadro infeccioso bacteriano agudo sinusal. .


Subject(s)
Animals , Female , Male , Rabbits , Disease Models, Animal , Rhinitis/microbiology , Sinusitis/microbiology , Acute Disease , Rhinitis/pathology , Sinusitis/pathology
9.
Rev. Soc. Bras. Med. Trop ; 47(4): 533-536, Jul-Aug/2014. graf
Article in English | LILACS | ID: lil-722298

ABSTRACT

Aspergillosis is an infection caused by saprophytic fungi of the genus Aspergillus, which typically occurs in immunosuppressed individuals, but has also been reported in immunocompetent patients. The main routes of entry are the respiratory tract, skin, cornea, and ear, and the infection may be localized or disseminated by contiguity or vascular invasion. We report a severe case of rhinosinusitis with cutaneous involvement, caused by invasive aspergillosis, in an immunocompetent user of inhaled cocaine. Invasive aspergillosis related to cocaine abuse has not yet been reported in the literature. After itraconazole treatment and surgical debridement, complete clinical remission was achieved. Nasal reconstruction with a skin graft over a silicone prosthesis resulted in a satisfactory esthetic outcome.


Subject(s)
Adult , Female , Humans , Aspergillosis/etiology , Cocaine-Related Disorders/complications , Nose Deformities, Acquired/microbiology , Rhinitis/microbiology , Sinusitis/microbiology , Immunocompromised Host
10.
Rev. chil. infectol ; 30(3): 319-322, jun. 2013. ilus
Article in Spanish | LILACS | ID: lil-679905

ABSTRACT

Curvularia inaequalis (Shear) Boedijn is a fungus dematiaceo, saprophyte and plant pathogen found mainly in tropical and subtropical areas, associated with various organic substrates. Rarely been identified in systemic infections, skin and there is only one report of allergic rhinosinusitis described above. A case of allergic fungal rhinosinusitis by Curvularia inaequalis (Shear) Boedijn in which diagnosis was considered the signs and symptoms, sinus CT and cultivation of mucin.The patient was treated with endoscopic surgical toilet, plus use of inhaled steroids and itraconazole systemic. With good clinical response, is asymptomatic at one year.


Curvularia inaequalis (Shear) Boedijn es un hongo dematiáceo, saprófito y fitopatógeno, presente principalmente en áreas tropicales y subtropicales, asociado a distintos sustratos orgánicos. Se ha identificado escasamente en infecciones sistémicas, cutáneas y sólo existe una comunicación de un caso de rinosinusitis alérgica descrito anteriormente. Presentamos el caso clínico de un paciente con una rinosinusitis alérgica fúngica por Curvularia inaequalis (Shear) Boedijn en cuyo diagnóstico se consideró los síntomas y signos clínicos, la TAC de senos paranasales y el cultivo de la mucina. El paciente fue tratado con un aseo quirúrgico por vía endoscópica, además del uso de corticoesteroides inhalatorios e itra-conazol sistémico. Presentó una buena respuesta clínica, encontrándose asintomático a un año del tratamiento.


Subject(s)
Humans , Male , Middle Aged , Ascomycota , Rhinitis, Allergic, Perennial/microbiology , Sinusitis/microbiology , Ascomycota/classification , Paranasal Sinuses , Tomography, X-Ray Computed
11.
Braz. j. otorhinolaryngol. (Impr.) ; 78(4): 35-41, jul.-ago. 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-646768

ABSTRACT

A rinossinusite é uma das principais causas de febre em pacientes críticos e deve ser sistematicamente pesquisada. OBJETIVO: Avaliar o impacto da punção do seio maxilar à beira leito, no diagnóstico e no tratamento dos pacientes com rinossinusite infecciosa internados em Unidade de Terapia Intensiva de um hospital universitário de alta complexidade. MATERIAIS E MÉTODOS: Estudo retrospectivo que avaliou os pacientes em ventilação mecânica com febre de origem indeterminada e sinais tomográficos de rinossinusite submetidos à punção do seio maxilar pelo meato inferior. RESULTADOS: A amostra total do estudo consistiu de 27 pacientes (70,3% do sexo masculino com média de idade 45,3 anos). Os diagnósticos de admissão mais frequentes na Unidade de Terapia Intensiva foram Trauma Crânio Encefálico e Acidente Vascular Cerebral. No exame tomográfico, os seios paranasais mais acometidos foram o maxilar, em 85,2%, e esfenoidal, em 74,1%. A secreção purulenta foi visualizada no meato médio em 30,7% das fossas nasais. Os microrganismos mais frequentes nos aspirados dos seios foram Pseudomonas aeruginosa e Acinetobacter baumannii. CONCLUSÃO: A punção do seio maxilar à beira leito demonstrou-se uma importante ferramenta diagnóstica e terapêutica nos pacientes de UTI com rinossinusite hospitalar, submetidos à ventilação mecânica invasiva.


Rhinosinusitis is one of the most commom causes of fever of unknown origin in critically ill patients and should be systematically searched. OBJECTIVE: This study aims to evaluate the diagnostic and therapeutic effect of maxillary sinus puncture performed at the bedside in patients with infective rhinosinusitis hospitalized in an Intensive Care Unit of a high complexity care hospital. MATERIALS AND METHODS: This retrospective study looks into patients on mechanical ventilation with fever of unknown origin and signs of rhinosinusitis on CT images who were submitted to inferior meatus maxillary sinus puncture. RESULTS: The total study sample consisted of 27 patients (70.3% male; mean age 45.3 years). The most common Intensive Care Unit admission diagnoses were head trauma and stroke. CT scans revealed the maxillary (85.2%) and sphenoid (74.1%) sinuses were the most involved paranasal sinuses. Middle meatus purulent drainage was seen in 30.7% of the nasal cavities. Fever was reduced in 70.4% of the patients after puncture (p < 0.001). The most commonly found organisms in sinus aspirates were Pseudomonas aeruginosa and Acinetobacter baumannii. CONCLUSION: Maxillary sinus puncture performed at the bedside of the patients is an important diagnostic and theraupetic tool for critically ill patients.


Subject(s)
Female , Humans , Male , Middle Aged , Cross Infection/diagnosis , Rhinitis/diagnosis , Sinusitis/diagnosis , Cross Infection/microbiology , Cross Infection/therapy , Intensive Care Units , Punctures , Retrospective Studies , Rhinitis/microbiology , Rhinitis/therapy , Sinusitis/microbiology , Sinusitis/therapy
13.
Indian J Med Microbiol ; 2012 Apr-June; 30(2): 229-232
Article in English | IMSEAR | ID: sea-143953

ABSTRACT

The aetiology of fungal sinusitis is diverse and changing. Aspergillus species has been the most common cause for fungal sinusitis, especially in dry and hot regions like India. Trichosporon species as a cause for fungal sinusitis has been very rarely reported the world over. Here, we report a rare case of allergic fungal sinusitis caused by Trichosporon inkin in a 28-year-old immunocompetent woman. Bilateral nasal obstruction, nasal discharge and loss of smell were her presenting complaints. Diagnostic nasal endoscopy showed bilateral multiple polyps. Functional endoscopic sinus surgery was performed and many polyps were removed. Based on mycological and histopathological studies, the pathogen was identified as T. inkin.


Subject(s)
Adult , Endoscopy , Female , Histocytochemistry , Humans , Hypersensitivity/diagnosis , Hypersensitivity/pathology , India , Nasal Cavity/pathology , Polyps/complications , Polyps/diagnosis , Polyps/surgery , Sinusitis/diagnosis , Sinusitis/microbiology , Sinusitis/pathology , Trichosporon/isolation & purification , Trichosporonosis/diagnosis , Trichosporonosis/microbiology , Trichosporonosis/pathology
14.
Rev. otorrinolaringol. cir. cabeza cuello ; 72(1): 15-22, abr. 2012. ilus
Article in Spanish | LILACS | ID: lil-627556

ABSTRACT

Introducción: La rinosinusitis, corresponde a un grupo de desórdenes que se caracteriza por la inflamación de la mucosa tanto de cavidades paranasales (CPN) como de fosas nasales. Está determinada por factores del huésped y ambientales que interactúan causando un estado inflamatorio persistente que produce remodelación de la mucosa. Entre éstos se destacan la alergia y otras alteraciones inmunológicas junto con la colonización por agentes infecciosos. Objetivo: Determinar las características demográficas, clínicas, inmunológicas y agentes infecciosos involucrados en la rinosinusitis crónica (RSC) y rinosinusitis aguda (RSA) recurrente de niños y adolescentes sometidos a cirugía endoscópica funcional (CEF). Establecer las posibles asociaciones de estas características con la necesidad de reoperación y la recurrencia de la enfermedad. Material y método: Estudio retrospectivo observacional en que se evalúan 28 niños y adolescentes sometidos a CEF en el servicio de ORL de Clínica Las Condes durante los años 2000 a 2009. Todos los pacientes contaban con estudio inmunológico y test cutáneo preoperatorio más biopsia de mucosa de CPN y cultivos intraoperatorios de secreción de CPN. Los análisis estadísticos se realizaron con test de Anova para los análisis descriptivos y para el análisis de grupos el test de Fisher. Considerando como significativo un p <0,05. Resultados: Se analizaron 28 pacientes; el 89,2 por ciento tuvo test cutáneo positivo y biopsia inflamatoria crónica eosinofílica (53,6(0) por ciento). El 17 por ciento presentó algún tipo de deficiencia inmunológica. Se obtuvo cultivos positivos intraoperatorios en el 71 por ciento de las muestras, en su mayoría agentes aeróbicos (57,1 por ciento), con 14,2 por ciento de anaerobios y sin presencia de hongos. Veinte y siete pacientes tuvieron seguimiento posoperatorio de 5 años. Cuatro de ellos (14 por ciento) debió ser reoperado...


Introduction: Rhino sinusitis is a group of disorders characterized by inflammation of the mucosa of both sinuses and nostrils. It is determined by environmental and host factors that interact causing a persistent inflammatory condition that causes remodeling of the mucosa. Chief among these are allergy and other immune disorders with colonization by infectious agents. Aim: To determine the demographic, clinical, immunologic and infectious agents involved in chronic Rhino sinusitis (CRS) and Recurrent Acute Rhino sinusitis (RAR) in children and adolescents undergoing functional endoscopic sinus surgery (FESS). Establish the possible associations of these characteristics with the need for re operation and recurrence of the disease. Material and method: Retrospective observational study that evaluated 28 children and adolescents involved in the ENT department at Clínica Las Condes, Santiago, Chile during the years 2000 to 2009. All study patients had preoperative Prick test, immune workout and intraoperative Para nasal mucosal biopsy and cultures of Para nasal secretion. Statistical analysis was performed using ANOVA test for descriptive analysis and cluster analysis with Fisher Exact test. Results were considered significant with p <0.05 Results: We analyzed 28 patients, 89.2 percent had positive Prick test and 53.6 percent showed biopsy with eosinophilic inflammatory disease. 17 percent had some type of immune deficiency. Positive intraoperative cultures were obtained in 71 percent of the samples, mostly aerobic agents (57.1 percent), with 14.2 percent anaerobes and negatives cultures for fungi. Twenty seven patients had postoperative follow-up of 5 years. Four of them (14 percent) had to be re-operated. During the monitoring period, 22 percent developed RAR. It was considered a poor surgical outcome the need for re-operation or recurrence of RAR. We couldn't find association of variables with a poor outcome after surgery...


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Endoscopy , Rhinitis/surgery , Sinusitis/surgery , Bacteriological Techniques , Follow-Up Studies , Recurrence , Reoperation , Retrospective Studies , Rhinitis/immunology , Rhinitis/microbiology , Skin Tests , Sinusitis/immunology , Sinusitis/microbiology
15.
Indian J Med Microbiol ; 2011 Oct-Dec; 29(4): 439-442
Article in English | IMSEAR | ID: sea-143876

ABSTRACT

Schizophyllum commune is widely distributed in the nature, but it rarely causes human infection. We have isolated this mould in a 46-year-old immunocompetent, non-diabetic patient with chronic sinusitis, previously treated with multiple antibiotics and topical steroid nasal drops with no response. Materials obtained from the nasal sinus during the endoscopic surgery, on KOH mount and histopathological study revealed broad septed hyaline hyphae. Growth on the Sabouraud's dextrose agar and potato dextrose agar produced white moulds with microscopic and macroscopic characters of S. commune. Till date there are few reports of S. commune sinusitis in immunocompetent individuals Worldwide. This is the first reported case in India to the best of our knowledge.


Subject(s)
Biopsy , Chronic Disease , Culture Media/chemistry , Female , Histocytochemistry , Humans , India , Microscopy , Middle Aged , Mycology/methods , Mycoses/diagnosis , Mycoses/pathology , Schizophyllum/cytology , Schizophyllum/growth & development , Schizophyllum/isolation & purification , Sinusitis/microbiology , Sinusitis/pathology
16.
Braz. j. otorhinolaryngol. (Impr.) ; 77(4): 522-525, July-Aug. 2011. tab
Article in English | LILACS | ID: lil-595801

ABSTRACT

Immunosuppressed patients are often susceptible to upper airway infections, especially those of the paranasal sinuses. These can sometimes jeopardize treatment success and even lead to a fatal outcome. OBJECTIVE: To study the paranasal microbiology of immunosuppressed patients with clinical evidence of rhinosinusitis, and compare it with that from immunocompetent patients. MATERIAL AND METHOD: Retrospective study, in which 42 immunosuppressed and 16 immunocompetent patients were selected. All had clinically evident acute or recurrent rhinosinusitis and were submitted to ethmoidal or sphenoid sinusectomy or maxillary sinus puncture to gather material for microbiological cultures. RESULTS: There were 92 percent positive cultures, and 21 percent were negative. Of the positive cultures, 38 percent were bacterial, with P. aeruginosa being the most frequent agent; 64 percent were fungal, which occurred in the most immunocompromised patients. In the immunocompetent group, there were 62. 5 percent positive cultures and 37. 5 percent negative ones. All the positive ones were bacterial, with no fungi. CONCLUSIONS: Transplant recipients were prone to develop bacterial rhinosinusitis by Gram positive and Gram negative agents, the most common of the latter being Pseudomonas aeruginosa. Fungal infections occurred in the severely immunosuppressed, and it was absent in immunocompetent patients.


Os pacientes imunossuprimidos têm maior risco de infecções de vias aéreas superiores, principalmente seios paranasais. Estas podem ter evolução fatal ou impedir a recuperação e o tratamento das doenças iniciais. OBJETIVO: Verificar a microbiologia dos seios paranasais dos pacientes imunossuprimidos com rinossinusite, em nosso serviço, e comparar com a microbiologia de pacientes imunocompetentes. MATERIAL E MÉTODO: Estudo retrospectivo, no qual foram selecionados 42 pacientes imunossuprimidos e 16 pacientes imunocompetentes. Todos tinham diagnóstico de rinossinusite aguda ou recorrente e foram submetidos à punção de seio maxilar ou sinusectomia etmoidal ou esfenoidal para coleta de secreção para cultura. RESULTADOS: Obteve-se 92 por cento de cultura positiva e 21 por cento negativa nos imunossuprimidos. Dos positivos, 38 por cento foram bacterianos e 64 por cento, fúngicos, sendo a bactéria mais frequente a P. aeruginosa. Os fungos apareceram nos pacientes com imunossupressão grave. Nos imunocompetentes, obteve-se cultura positiva em 62,5 por cento dos pacientes, e negativa em 37,5 por cento deles, com 100 por cento de positividade para bactérias e ausência de fungos. CONCLUSÃO: Pacientes imunossuprimidos adquirem rinossinusites por bactérias Gram positivas, Gram negativas das mais diversas espécies, sendo Pseudomonas aeruginosa a mais frequente. As infecções fúngicas são mais frequentes em pacientes imunossuprimidos graves e ausentes em imunocompetentes.


Subject(s)
Adult , Female , Humans , Male , Fungi/isolation & purification , Gram-Negative Bacteria/isolation & purification , Gram-Positive Bacteria/isolation & purification , Immunocompromised Host , Rhinitis/microbiology , Sinusitis/microbiology , Acute Disease , Hospitals, University , Immunocompetence , Recurrence , Retrospective Studies , Rhinitis/immunology , Sinusitis/immunology
18.
Journal of Medical Council of Islamic Republic of Iran. 2010; 28 (2): 163-168
in Persian | IMEMR | ID: emr-97863

ABSTRACT

Chronic rhinosinusitis is one of the most common chronic diseases which can adversely affect patients' quality of life with a considerable economical burden. Bacteriology of chronic rhino sinusitis is not well defined. Recently, Helicobacter pylori gained a considerable concern in respect to its probable association with upper respiratory tract diseases. This study aimed to evaluate the relationship between H. pylori colonization in sinonasal mucosa and chronic rhinosinusitis. This case-control study was conducted in Ayatollah Taleghani General Hospital - Tehran in 2007-2008. All patients with chronic rhinosinusitis who failed to respond to the medical therapy [32 patients], enrolled as case group and samples were taken from involved sinonasal mucosa during endoscopic surgery. Patients with nasal septum deviation [65 cases] recruited as control group and samples were evaluated for Helicobacter colonization by using polymerase chain reaction [PCR] technique and results in two groups were compared. 97 patients [61% male and 39% female] were studied ranging in age from 12 to 53 years, with an average of 29.6 years. Out of 32 patients in the case group, 56% were male and 44% female, aging from 12 to 53 years [averagely 32.16 years]. 65 cases of the control group [63% male and 37% female] were 16-50 years old with an average age of 28.34 years. After the evaluation of samples from 97 patients in both study groups, 16 patients out of 32 in chronic rhino sinusitis group [50%] and 7 out of 65 patients in control group [10.7%] had positive results for helicobacter colonization in their sinonasal and bulla ethmoidalis mucosa which was statistically significant [p<0.001, and Odds Ratio= 8.28, 95% CI= 2.9-23.59]. There was no statistically significant relation between H. pylori colonization and site of involved sinus or typical symptoms of gastro-esophageal reflux. According to the results of current study, there was a significantly higher rate of Helicobacter pylon colonization in chronic rhinosinusitis patients compared to the control group. This finding suggests that Helicobacter pylori may play an etiologic role in pathogenesis of chronic rhinosinusitis


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Paranasal Sinuses/microbiology , Sinusitis/microbiology , Case-Control Studies
19.
Braz. j. otorhinolaryngol. (Impr.) ; 75(6): 788-793, nov.-dez. 2009. ilus, tab
Article in English, Portuguese | LILACS | ID: lil-539372

ABSTRACT

Apatogenia da rinossinusite crônica não está completamente estabelecida e existem algumas explicações para essa doença, como a osteíte, os superantígenos, a hipersensibilidade mediada por fungos e, mais recentemente, o biofilme. Não existem publicações na língua portuguesa sobre biofilmes na rinossinusite crônica. Objetivo: Reproduzir um método para evidenciar a presença de biofilmes em pacientes com rinossinusite crônica com polipose nasossinusal. Material e método: Amostras de bula etmoidal de nove pacientes com rinossinusite crônica com polipose nasossinusal sem resposta ao tratamento clínico submetidos à cirurgia foram analisadas com microscopia eletrônica de varredura para evidenciar o biofilme. Desenho do estudo: Estudo de coorte contemporânea com corte transversal. Resultados: Observamos o biofilme em 55,56 por cento (5/9) dos pacientes, através da visualização da estrutura tridimensional, de estruturas esféricas envolvidas por uma matriz amorfa e dos canais de água. Conclusão: Reproduzimos um método de visualização de biofilme bacteriano através da microscopia eletrônica de varredura e evidenciamos a sua presença nos pacientes com rinossinusite crônica com polipose nasossinusal.


Chronic rhinosinusitis pathogenesis is not completely established and there are some explanations for this disease, such as osteitis, superantigens, fungal-mediated hypersensitivity and, more recently, biofilms. There are no reports in Portuguese about biofilms in chronic rhinosinusitis. AIM: To reproduce a method for visualization of biofilms in patients with chronic rhinosinusitis and nasal polyps. Patients and methods: Samples of ethmoid bulla of nine patients with chronic rhinosinusitis with nasal polyps without response to clinical treatment who underwent surgery were analyzed with scanning electron microscopy to evidence bacterial biofilms. Study design: A contemporary cross-sectional cohort study Results: In 55.56 percent (5/9) of the patients we observed biofilms by seeing three-dimensional structures, spherical structures surrounded by an amorphous matrix and water-channels. Conclusion: We reproduced a method for visualization of bacterial biofilms by scanning electron microscopy and evidenced its presence in chronic rhinosinusitis with nasal polyps.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Biofilms , Nasal Mucosa/microbiology , Nasal Polyps/microbiology , Rhinitis/microbiology , Sinusitis/microbiology , Chronic Disease , Cohort Studies , Cross-Sectional Studies , Microscopy, Electron, Scanning , Nasal Mucosa/ultrastructure , Nasal Polyps/surgery , Pilot Projects , Reproducibility of Results , Rhinitis/surgery , Sinusitis/surgery
20.
Rev. chil. infectol ; 26(5): 453-456, oct. 2009. ilus
Article in Spanish | LILACS | ID: lil-532138

ABSTRACT

Scedosporium species can cause colonization, superficial and deep localized infection or systemic disease, espe-cially in irnmunocompromised hosts. We report a case of localized infection due to Scedosporium apiospermum in a 47 year oíd woman, with previous nasal surgery. She consulted for recurrent mucopurulent post-nasal discharge not responding to antibiotics. Computed tomography showed opacification of right maxillary sinus. Surgery was performed to removed abnormal tissue from sinus; biopsy revealed chronic sinusitis with aggregate of tightly packed hyphae suggestive of filamentous fungi. The microbiology fungal culture reported Scedosporium apiospermum.


Las infecciones por Scedosporium sp pueden traducirse en colonización, infecciones localizadas superficiales y profundas, o enfermedad diseminada. Presentamos un caso clínico de infección rinosinusal por Scedosporium apiospermum en una paciente de 47 años, con antecedente de cirugía por cuerpo extraño en la fosa nasal derecha. Consultó por descarga posterior muco-purulenta y recurrente, sin respuesta a tratamiento antibacteriano. Las imágenes de cavidades paranasales mostraron opacidad del seno maxilar derecho. Se realizó cirugía de remoción de contenido sinusal cuyo estudio histológico reveló sinusitis crónica erosiva, colonias de hongos con morfología sugerente de hongo filamentoso y desarrollo de S. apiospermum en el cultivo.


Subject(s)
Female , Humans , Middle Aged , Immunocompetence , Mycetoma/microbiology , Rhinitis/microbiology , Scedosporium/isolation & purification , Sinusitis/microbiology , Chronic Disease , Mycetoma/diagnosis , Mycetoma/surgery , Rhinitis/diagnosis , Rhinitis/surgery , Sinusitis/diagnosis , Sinusitis/surgery
SELECTION OF CITATIONS
SEARCH DETAIL