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1.
An. bras. dermatol ; 96(6): 726-729, Nov.-Dec. 2021. graf
Article in English | LILACS | ID: biblio-1355633

ABSTRACT

Abstract Carney complex is a rare genodermatosis characterized by cardiac and cutaneous myxomas, among other tumors. In the majority of cases, cutaneous myxomas precede the diagnosis of cardiac myxomas, which are the main cause of death in these patients. Despite the fact that the diagnosis of cutaneous myxomas is histopathological, high-frequency ultrasonography plays an essential role in the differential diagnosis with other cutaneous and subcutaneous tumors. The authors of the present study describe, for the first time in the literature, the ultrasonographic features of both variants of cutaneous myxomas, superficial and subcutaneous, in a patient with a Carney complex.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Carney Complex/diagnostic imaging , Heart Neoplasms/diagnostic imaging , Myxoma/diagnostic imaging , Diagnosis, Differential
2.
An. bras. dermatol ; 96(5): 609-612, Sept.-Oct. 2021. graf
Article in English | LILACS | ID: biblio-1345155

ABSTRACT

Abstract The penile localization of pigmented Bowen's disease has been rarely reported and has been mostly related to human papillomavirus infection. Early diagnosis and treatment are important to prevent progression to invasive squamous cell carcinoma. However, diagnosis can be challenging because it may be difficult to distinguish from melanoma, even using dermoscopy. Reflectance confocal microscopy may be useful in suggesting the bedside diagnosis before the histopathological confirmation. A case of penile pigmented Bowen's disease is described along with its dermoscopy and reflectance confocal microscopy findings and their correlation with histopathology.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Bowen's Disease/diagnostic imaging , Microscopy, Confocal , Dermoscopy , Diagnosis, Differential
4.
An. bras. dermatol ; 96(4): 422-428, July-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1285110

ABSTRACT

Abstract Background: Pemphigus foliaceus is exceedingly rare around the world, except within the few regions where it occurs as an endemic variant. Various factors can trigger immune mechanisms that induce pemphigus foliaceus or worsen its course. Objective: To determine the demographic and clinical characteristics of the patients with pemphigus foliaceus in a large series from a non-endemic country, investigate the triggering factors, and seasonal patterns. Methods: The data of the patients diagnosed with pemphigus foliaceus in the study's center between 1989-2018 were retrospectively analyzed. Results: Sixty-eight patients (mean age, 45.7 ± 14.5 years) were included in the study. The number of onsets reached its peak in spring-summer (p = 0.008). A total of 117 relapses occurred in 42 patients and were most common in spring-summer (not significant). Specific trigger factors were detected in 45 relapses. In the other 72 relapses, the peak was observed in spring-summer (p = 0.005). There were no significant differences in the demographic and clinical variables investigated between relapsed and non-relapsed patients. Study limitations: Retrospective design. Conclusions: Triggering factors could not be identified in more than half of the relapses in the study's series. The subgroup of relapses (without identified causes), as well as the onsets of the disease, showed a significant seasonal variation with a peak in spring-summer; however, the seasonal variable did not justify the total group of relapses. Although the seasonal variation may be caused by a combination of factors, UV radiation should be considered a trigger factor for the peaks in spring-summer, particularly in Turkey.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Acanthoma/diagnostic imaging , Dermoscopy
5.
An. bras. dermatol ; 96(2): 139-147, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1248748

ABSTRACT

Abstract Background: Dermoscopy increases the sensitivity of the diagnosis of melanoma, leading to its early identification and increasing the chances of cure. Objective: To describe the clinical and dermoscopic characteristics of superficial spreading melanomas, and to detect the differences between in situ and invasive 1-mm thick melanomas. Methods: This was a cross-sectional study in which dermoscopic images of 58 melanomas, grouped according to their thickness, were evaluated. Results: 24 in situ melanomas were evaluated, 28 invasive melanomas with Breslow ≤ 1 mm (0.50 ± 0.22 mm) and six with Breslow > 1 mm (2.35 ± 2.02 mm). In situ melanomas were smaller than invasive melanomas. The most commonly found dermoscopic criteria were asymmetry (84.5%), three or more colors (81.0%), and atypical network (79.3%). A non-specific pattern was more common in in situ melanomas (p = 0.028) and atypical network in invasive melanomas with Breslow 1 mm presented inverted network (p = 0.018). Study limitations: The sample was selected by convenience, since it was necessary to have a preoperative photo of the tumor, which may have led to the loss of clinically less significant lesions, as well as those highly suggestive of melanoma. Conclusions: Melanomas in early stages showed a more frequent nonspecific pattern and atypical network, while invasive melanomas showed a multicomponent pattern, three or more colors, and an inverted network.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Melanoma/diagnostic imaging , Cross-Sectional Studies , Retrospective Studies , Dermoscopy
6.
An. bras. dermatol ; 95(6): 748-750, Nov.-Dec. 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1142128

ABSTRACT

Abstract Polypoid melanoma is a variant of nodular melanoma, whose poor prognosis depends on its thickness and the presence of ulceration at the time of diagnosis. The authors report two cases of polypoid melanoma, presenting as broad, cauliflower-like, polypoid masses. Dermoscopy was characterized by a multicolored pattern, atypical polymorphic vessels, and the fiber sign. Clinical and dermoscopic features can help to diagnose polypoid melanoma and exclude other possible differential diagnoses. However, histology remains mandatory to confirm the diagnostic suspicion.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Melanoma/diagnostic imaging , Skin , Dermoscopy , Diagnosis, Differential
7.
An. bras. dermatol ; 95(6): 773-775, Nov.-Dec. 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1142115
8.
An. bras. dermatol ; 95(3): 379-382, May-June 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130887

ABSTRACT

Abstract In situations in when a dermoscopic record of a large lesion is desirable, the resulting images are usually restricted to a small field of view due to the limited diameter of dermatoscope lenses. This limitation often produces several photographs separately, thus losing the possibility of a single-image global evaluation. In these case reports, we show examples of a recently published image montage technique called Wide Area Digital Dermoscopy, in this case, applied to basal cell carcinomas.


Subject(s)
Humans , Male , Skin Neoplasms/diagnostic imaging , Image Processing, Computer-Assisted/methods , Carcinoma, Basal Cell/diagnostic imaging , Dermoscopy/methods , Skin Neoplasms/pathology , Software , Carcinoma, Basal Cell/pathology , Reproducibility of Results , Middle Aged
11.
An. bras. dermatol ; 95(1): 95-97, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088711

ABSTRACT

Abstract The Borst-Jadassohn phenomenon is a morphological finding that consists of the presence of well-defined nests of cells located in the spiny stratum of an acanthotic epidermis. One of the neoplasms where this phenomenon is found is hidroacanthoma simplex. This neoplasm is considered the intraepidermal form of the eccrine poroma. Despite its benign nature, malignant transformations are reported. The present article reports a case of hidroacanthoma simplex and discusses the dermoscopy of this phenomenon.


Subject(s)
Humans , Female , Aged, 80 and over , Skin Neoplasms/pathology , Skin Neoplasms/diagnostic imaging , Acanthoma/pathology , Acanthoma/diagnostic imaging , Biopsy , Dermoscopy/methods , Epidermis/pathology , Epidermis/diagnostic imaging
12.
An. bras. dermatol ; 94(6): 637-657, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1054878

ABSTRACT

Abstract Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection. They may also be pigmented and show variable degrees of infiltration; when multiple they then constitute the so-called field cancerization. Their prevalence ranges from 11% to 60% in Caucasian individuals above 40 years. Ultraviolet radiation is the main factor involved in pathogenesis, but individual factors also play a role in the predisposing to lesions appearance. Diagnosis of lesions is based on clinical and dermoscopic examination, but in some situations histopathological analysis may be necessary. The risk of transformation into squamous cell carcinoma is the major concern regarding actinic keratoses. Therapeutic modalities for actinic keratoses include topical medications, and ablative and surgical methods; the best treatment option should always be individualized according to the patient.


Subject(s)
Humans , Dermoscopy/methods , Keratosis, Actinic/therapy , Keratosis, Actinic/diagnostic imaging , Skin Neoplasms/pathology , Skin Neoplasms/diagnostic imaging , Severity of Illness Index , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/diagnostic imaging , Risk Factors , Keratosis, Actinic/pathology
13.
Rev. Hosp. Ital. B. Aires (2004) ; 39(3): 98-100, sept. 2019. ilus.
Article in Spanish | LILACS | ID: biblio-1048365

ABSTRACT

El adenocarcinoma mucinoso primario de piel es una neoplasia anexial, maligna e infrecuente, que afecta principalmente a hombres en una relación 2:1 con respecto a las mujeres. Presenta mayor incidencia entre la sexta y séptima década de la vida, y se manifiesta como un tumor único, asintomático, de tamaño variable. La localización más frecuente es la región periorbitaria y el cuero cabelludo. Se comunica el caso de una paciente de 92 años, con diagnóstico de carcinoma mucinoso primario de piel, sin evidencia de enfermedad sistémica ni recurrencia local al año de la resección por cirugía micrográfica de Mohs. Describimos sus principales características clínicas, dermatoscópicas y hallazgos histopatológicos. (AU)


Primary mucinous adenocarcinoma of the skin is an adnexal, malignant, and infrequent neoplasm that mainly affects men with a 2: 1 ratio, with respect to women. It presents higher incidence between the sixth and seventh decade of life, and manifests as a single tumor, asymptomatic, of variable size. The most frequent location is the periorbital region and scalp. We report the case of a 92-year-old patient with a diagnosis of primary mucinous skin carcinoma, without evidence of systemic disease or local recurrence one year after resection by Mohs micrographic surgery. We describe its main clinical features, dermatoscopic and histopathological findings. (AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Skin Neoplasms/diagnostic imaging , Adenocarcinoma, Mucinous/diagnostic imaging , Neoplasm Metastasis/diagnostic imaging , Scalp/pathology , Carcinoma, Squamous Cell/surgery , Adenocarcinoma, Mucinous/surgery , Adenocarcinoma, Mucinous/etiology , Adenocarcinoma, Mucinous/ultrastructure , Adenocarcinoma, Mucinous/epidemiology , Eccrine Glands/ultrastructure
14.
An. bras. dermatol ; 93(6): 899-901, Nov.-Dec. 2018. graf
Article in English | LILACS | ID: biblio-973631

ABSTRACT

Abstract: Dermoscopic examination allows visualization of horizontal images on the skin, showing well-defined patterns. The authors propose ex vivo dermoscopic visualization using a vertical view of skin sections. The new image clearly distinguishes the stratum corneum, epidermis, and dermis as well as the anatomical location of the pigment. Will this new approach be useful in dermoscopic diagnosis? Further studies are needed.


Subject(s)
Humans , Male , Skin Neoplasms/diagnostic imaging , Dermoscopy/methods , Melanoma/diagnostic imaging , Nevus, Pigmented/diagnostic imaging , Skin Neoplasms/pathology , Biopsy , Reproducibility of Results , Diagnosis, Differential , Melanoma/pathology , Nevus, Pigmented/pathology
16.
An. bras. dermatol ; 93(1): 114-115, Jan.-Feb. 2018. graf
Article in English | LILACS | ID: biblio-887164

ABSTRACT

Abstract: Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically indolent lesions on the nail unit can shorten the diagnostic process and avoid destructive treatment and functional damage.


Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/diagnostic imaging , Carcinoma, Basal Cell/diagnostic imaging , Carcinoma, Basosquamous/diagnostic imaging , Nail Diseases/diagnostic imaging , Skin Neoplasms/pathology , Carcinoma, Basal Cell/pathology , Carcinoma, Basosquamous/pathology , Dermoscopy , Nail Diseases/pathology
17.
An. bras. dermatol ; 92(4): 565-567, July-Aug. 2017. graf
Article in English | LILACS | ID: biblio-887002

ABSTRACT

Abstract: Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. The uvea is the most common site of origin of ocular melanomas, while conjunctival melanoma accounts for about 1-5% of cases. In this article, we describe a rare case of synchronic conjunctival melanoma and lentigo maligna on the face.


Subject(s)
Humans , Male , Female , Aged, 80 and over , Skin Neoplasms/pathology , Hutchinson's Melanotic Freckle/pathology , Conjunctiva/pathology , Conjunctival Neoplasms/pathology , Melanoma/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/diagnostic imaging , Biopsy , Hutchinson's Melanotic Freckle/diagnostic imaging , Conjunctiva/diagnostic imaging , Conjunctival Neoplasms/diagnostic imaging , Dermoscopy , Face , Melanoma/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging
18.
Rev. Assoc. Med. Bras. (1992) ; 63(2): 109-111, Feb. 2017. graf
Article in English | LILACS | ID: biblio-842538

ABSTRACT

Summary Early diagnosis and staging of non-Hodgkin lymphoma (NHL) is essential for therapeutic strategy decision. Positron emission tomography/computed tomography (PET/CT) with fluordeoxyglucose (FDG), a glucose analogue, labeled with fluor-18 (18F-FDG) has been used to evaluate staging, therapy response and prognosis in NHL patients. However, in some cases, 18F-FDG has shown false-positive uptake due to inflammatory reaction after chemo and/or radiation therapy. In this case report, we present a NHL patient evaluated with 18F-FDG and 18F-choline PET/CT scan imaging pre- and post-therapy. 18F-FDG and 18F-choline PET/CT were performed for the purpose of tumor staging and have shown intense uptake in infiltrative tissue as well as in the lymph node, but with some mismatching in the tumor. Post-treatment 18F-FDG and 18F-choline PET/ CT scans revealed no signs of radiotracer uptake, suggesting complete remission of the tumor. 18F-choline may be a complimentary tool for staging and assessment of therapeutic response in non-Hodgkin lymphoma, while non-18F-FDG tracer can be used for targeted therapy and patient management.


Subject(s)
Humans , Male , Skin Neoplasms/diagnostic imaging , Lymphoma, Non-Hodgkin/diagnostic imaging , Choline , Radiopharmaceuticals , Neoplasms/diagnostic imaging , Sternum , Fluorodeoxyglucose F18 , Positron Emission Tomography Computed Tomography , Lymph Nodes/diagnostic imaging , Middle Aged , Neoplasm Staging
19.
Yonsei Medical Journal ; : 51-58, 2017.
Article in English | WPRIM | ID: wpr-65063

ABSTRACT

PURPOSE: We aimed to investigate the effectiveness of ferritin as a contrast agent and a potential reporter gene for tracking tumor cells or macrophages in mouse cancer models. MATERIALS AND METHODS: Adenoviral human ferritin heavy chain (Ad-hFTH) was administrated to orthotopic glioma models and subcutaneous colon cancer mouse models using U87MG and HCT116 cells, respectively. Brain MR images were acquired before and daily for up to 6 days after the intracranial injection of Ad-hFTH. In the HCT116 tumor model, MR examinations were performed before and at 6, 24, and 48 h after intratumoral injection of Ad-hFTH, as well as before and every two days after intravenous injection of ferritin-labeled macrophages. The contrast effect of ferritin in vitro was measured by MR imaging of cell pellets. MRI examinations using a 7T MR scanner comprised a T1-weighted (T1w) spin-echo sequence, T2-weighted (T2w) relaxation enhancement sequence, and T2*-weighted (T2*w) fast low angle shot sequence. RESULTS: Cell pellet imaging of Ad-hFTH in vitro showed a strong negatively enhanced contrast in T2w and T2*w images, presenting with darker signal intensity in high concentrations of Fe. T2w images of glioma and subcutaneous HCT116 tumor models showed a dark signal intensity around or within the Ad-hFTH tumor, which was distinct with time and apparent in T2*w images. After injection of ferritin-labeled macrophages, negative contrast enhancement was identified within the tumor. CONCLUSION: Ferritin could be a good candidate as an endogenous MR contrast agent and a potential reporter gene that is capable of maintaining cell labeling stability and cellular safety.


Subject(s)
Animals , Brain Neoplasms/diagnostic imaging , Cell Line, Tumor , Cell Tracking/methods , Colonic Neoplasms/diagnostic imaging , Contrast Media/administration & dosage , Disease Models, Animal , Female , Ferritins/administration & dosage , Genes, Reporter , Glioma/diagnostic imaging , Humans , Injections, Intravenous , Macrophages , Magnetic Resonance Imaging/methods , Male , Mice , Neoplasm Transplantation , Skin Neoplasms/diagnostic imaging , Time Factors
20.
An. bras. dermatol ; 91(6): 764-769, Nov.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-837998

ABSTRACT

Abstract BACKGROUND: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod. OBJECTIVE: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. METHOD: The authors designed a prospective study. Patients with pigmented basal cell carcinoma were included and data regarding the dermatoscopy features were collected following the Menzies criteria, prior to initiating the imiquimod treatment. Subsequent dermatoscopic evaluations were performed at weeks 4 and 8, following imiquimod discontinuation. RESULTS: Twenty lesions were included. The most common pigmented dermatoscopy features were large blue-grey ovoid nests (80%), followed by blue-grey globules (50%) and leaf-like areas (30%). No spoke wheel areas were observed. In 17 out of 20 patients, a response was noted during the first evaluation at 4 weeks, while the clearance was noted at the second check-up after 8 weeks. In two patients, the clearance was found at the initial evaluation at 4 weeks, while in one patient, the response remained unchanged. Blue-grey globules were the fastest to exhibit clearance (50% at week 4), followed by leaf-like areas (15%) and large blue-grey ovoid nests (6.25%). CONCLUSION: According to our results, dermatoscopic evaluation enhances the accuracy in the assessment of the clinical response to imiquimod in pigmented basal cell carcinoma.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Skin Neoplasms/diagnostic imaging , Carcinoma, Basal Cell/drug therapy , Carcinoma, Basal Cell/diagnostic imaging , Dermoscopy/methods , Aminoquinolines/therapeutic use , Antineoplastic Agents/therapeutic use , Pigmentation Disorders/pathology , Pigmentation Disorders/drug therapy , Pigmentation Disorders/diagnostic imaging , Skin/pathology , Skin Neoplasms/pathology , Time Factors , Carcinoma, Basal Cell/pathology , Prospective Studies , Reproducibility of Results , Treatment Outcome
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