Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 371
Filter
1.
Ciênc. Saúde Colet ; 26(10): 4737-4748, out. 2021. tab
Article in English, Portuguese | LILACS | ID: biblio-1345687

ABSTRACT

Resumo Este estudo de corte transversal investigou a associação entre raça/cor autorrelatada e dois desfechos - demanda psicossocial e demanda física no trabalho - em 1.032 trabalhadores da Limpeza Urbana e da Indústria Calçadista, na Bahia. Mensurou-se demanda psicossocial por meio do Job Content Questionnaire e demanda física, com questões sobre posturas e manuseio de carga. Regressão de Cox forneceu razões de prevalência (RP) ajustadas por idade, sexo e escolaridade. Entre os pretos há maior proporção de coletores de lixo e menor proporção de cargos de supervisão. Trabalhadores pretos estão mais submetidos à alta demanda psicológica e à baixo controle e, consequentemente, à mais alta exigência no trabalho (RP=1,65). Ademais, são mais expostos ao trabalho com braços elevados (RP=1,93) e ao manuseio de carga (RP=1,62), comparados com brancos. Pardos estão mais expostos ao baixo controle (RP=1,36), ao trabalho com braços elevados (RP=1,48) e com manuseio de carga (RP=1,25), também comparados com brancos. Apoio social é mais baixo entre os pretos e pardos. O estudo demonstrou iniquidades nas exposições psicossocial e física no trabalho que estão em acordo com a concepção estrutural do racismo e sua evidência pode contribuir para condutas que ampliem a equidade no mundo do trabalho.


Abstract This cross-sectional study investigated the association between self-reported race/skin color and two outcomes - psychosocial demand and physical demand at work - in 1,032 workers in an urban cleaning services company and two footwear manufacturers, located in the State of Bahia, Brazil. Psychosocial demand was measured through the Job Content Questionnaire and physical demand was measured through questions about postures and cargo handling. A Cox regression analysis provided prevalence ratios (PR) adjusted by age, gender, and educational level. Among blacks, there is a higher proportion of garbage collectors and a lower proportion of supervisory positions. Black workers are more subject to high psychological demand and low job control and, consequently, to high strain (PR=1.65). Also, they are more exposed to work with arms above shoulder level (PR=1.93), and material handling (PR=1.62), compared to white workers. Brown workers are more exposed to low job control (PR=1.36), work with arms above shoulder level (PR=1.48), and material handling (PR=1.25), also compared with whites. Social support is lower among blacks and brown. The study demonstrated inequities in psychosocial and physical exposures at work that are in line with the structural conception of racism. This evidence can contribute to the adoption of practices that increase equity in the world of work.


Subject(s)
Humans , Skin Pigmentation , Brazil , Prevalence , Cross-Sectional Studies , Surveys and Questionnaires
2.
Article in English | WPRIM | ID: wpr-922184

ABSTRACT

BACKGROUND@#Given the important repercussions that sociodemographic factors can have on physical activity, especially in the field of leisure, and cardiometabolic risk, it seems relevant to analyze the implications of these variables on the relationship between physical activity in leisure time (LTPA) and cardiometabolic risk. In this sense, the present study aims to verify the moderating role of biologic and socioeconomic factors in the relationship between LTPA and cardiometabolic risk in adolescents in southern Brazil.@*METHODS@#Cross-sectional study that included 1596 adolescents selected at random (58.2% girls), aged between 10 and 17 years. LTPA, biological and socioeconomic factors were assessed using a self-reported questionnaire and the cardiometabolic risk score (total cholesterol/HDL-c ratio, triglycerides, fasting glucose, systolic blood pressure, and waist circumference, considering the participant's age and sex) was included as an outcome. Associations and moderations were tested by multiple linear regression models.@*RESULTS@#It was observed a positive interaction of LTPA and sex (p = 0.048) and LTPA and school system (p = 0.037), and negative interaction of LTPA and skin color (p = 0.040), indicating that these factors were moderators in the relationship between LTPA and clustered cardiometabolic risk score (cMetS) in adolescents. A reduction in cardiometabolic risk was observed according to the increase in weekly minutes of LTPA among boys, non-white adolescents, and students from municipal schools.@*CONCLUSIONS@#The association between LTPA and cardiometabolic risk was moderated by sex, skin color, and school system in adolescents from southern Brazil.


Subject(s)
Adolescent , Age Factors , Brazil/epidemiology , Cardiometabolic Risk Factors , Child , Cross-Sectional Studies , Effect Modifier, Epidemiologic , Exercise , Female , Humans , Leisure Activities , Male , Sex Factors , Skin Pigmentation , Socioeconomic Factors
3.
Cad. Saúde Pública (Online) ; 37(11): e00224220, 2021. tab
Article in English | LILACS | ID: biblio-1350390

ABSTRACT

Abstract: This study aims to investigate whether the intersectional identities defined by race/skin color and gender are associated with smoking and excessive consumption of alcohol in a representative sample of Brazilian adults. This is a cross-sectional study with 48,234 participants in the Brazilian National Health Survey (PNS) - 2013. Crude and adjusted odds ratios (OR) and respective 95% confidence intervals (95%CI) were used to estimate the associations of intersectional categories of race/skin color and gender (white woman, brown woman, black woman, white man, brown man, black man) with smoking and excessive consumption of alcohol, based on the combination of weekly "days" and "servings". The prevalence of smoking varied from 10.6% for white women to 23.1% for black men, while the prevalence of elevated consumption of alcohol ranged from 3.3% to 14%, respectively. In comparison to white women, only white, brown, and black men presented greater chances of smoking, reaching the OR of 2.04 (95%CI: 1.66-2.51) in black men. As to excessive consumption of alcohol, all intersectional categories showed greater chances of consumption than white women, with the greatest magnitude in black men (OR = 4.78; 95%CI: 3.66-6.23). These associations maintained statistical significance after adjustments made for sociodemographic, behavioral, and health characteristics. Results demonstrated differences in smoking habit and excessive consumption of alcohol when the intersectional categories were compared to traditional analyses. These findings reinforce the significance of including intersectionality of race/skin color and gender in epidemiological studies.


Resumo: O estudo teve como objetivo investigar se as interseções de identidades definidas por raça/cor e gênero estão associadas ao tabagismo e ao consumo excessivo de álcool em uma amostra representativa de adultos brasileiros. Este foi um estudo transversal com 48.234 participantes da Pesquisa Nacional de Saúde (PNS) de 2013. Foram usadas odds ratio (OR) brutas e ajustadas com os respectivos intervalos de 95% de confiança (IC95%) para estimar as associações entre interseções de categorias de raça/cor e gênero (mulher branca, mulher parda, mulher preta, homem branco, homem pardo, homem preto) com tabagismo e consumo excessivo de álcool, derivados da combinação de "dias" e "doses" semanais. A prevalência de tabagismo variou de 10,6% em mulheres brancas a 23,1% em homens pretos, enquanto a prevalência de consumo elevado de álcool variou de 3,3% a 14%, respectivamente. Em comparação com mulheres brancas, apenas homens brancos, pardos e pretos apresentaram risco maior de tabagismo, chegando a um OR de 2,04 (IC95%: 1,66-2,51) em homens pretos. Quanto ao consumo excessivo de álcool, todas as categorias mostraram maior risco de consumo em comparação com as mulheres brancas, com a maior magnitude em homens pretos (OR = 4,78; IC95%: 3,66-6,23). As associações mantiveram a significância estatística depois de ajustar para fatores sociodemográficos, comportamentais e de saúde. Os resultados revelam diferenças no hábito de fumar e no consumo excessivo de álcool quando as categorias de interseções foram comparadas a análises tradicionais. Os achados reforçam a importância da inclusão de raça/cor e gênero em estudos epidemiológicos.


Resumen: El objetivo fue investigar si las identidades interseccionales, definidas por raza/color de piel y género, están asociadas con el consumo de tabaco y excesivo consumo de alcohol en una muestra representativa de adultos brasileños. Se trata de un estudio trasversal con 48.234 participantes en la Encuesta Nacional de Salud Brasileña (PNS) - 2013. Las odds ratio (OR) crudas y ajustadas y los respectivos intervalos de 95% confianza (IC95%) fueron usados para estimar las asociaciones de categorías interseccionales de raza/color de piel y género (mujer blanca, mujer mestiza, mujer negra, hombre blanco, hombre mestizo, hombre negro) con el consumo de tabaco y el excesivo consumo de alcohol, derivado de la combinación semanal de "días" y "cantidades consumidas". La prevalencia de consumo de tabaco varió de 10.6% en mujeres blancas al 23,1% en hombres negros, mientras que la prevalencia de consumo elevado de alcohol fue de un 3,3% al 14%, respectivamente. En comparación con las mujeres blancas, solo blancos, mestizos, y hombres negros presentaron oportunidades mayores de fumar, alcanzando la OR de 2,04 (95%CI: 1,66-2,51) en hombres negros. Así como que, para el excesivo consumo de alcohol, todas las categorías interseccionales mostraron oportunidades mayores de consumo que las mujeres blancas, con una magnitud más grande en hombres negros (OR = 4,78; 95%CI: 3,66-6,23). Estas asociaciones mantuvieron significancia estadística, tras los ajustes realizados para características sociodemográficas, comportamentales, y características de salud. Los resultados demostraron que el hábito de fumar y el excesivo consumo de alcohol mostraron diferencias cuando se compararon las categorías interseccionales con los análisis tradicionales. Estos resultados refuerzan la importancia de incluir la interseccionalidad de raza/color de piel y género en estudios epidemiológicos.


Subject(s)
Humans , Male , Female , Adult , Skin Pigmentation , Brazil/epidemiology , Alcohol Drinking/epidemiology , Smoking/epidemiology , Cross-Sectional Studies , Health Surveys
4.
Arq. bras. med. vet. zootec. (Online) ; 72(4): 1458-1468, July-Aug. 2020. tab, ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1131474

ABSTRACT

Caracterizaram-se fêmeas F1 Holandês x Zebu de diferentes bases maternas quanto às pelagens, despigmentações e características morfométricas. Foram utilizadas 266 fêmeas F1, progênies do cruzamento de 26 touros da raça Holandesa com fêmeas de composição genética zebuínas: Gir, Nelore, Guzonel, Nelogir. Foram aplicadas análise de distribuição de frequência para características qualitativas e medidas de dispersão e tendência central para características morfométricas, e as médias foram comparadas pelo teste de Tukey a 5% de probabilidade. Acima de 60,0% dos animais foram de pelagem preta. As vacas que tiveram origem na raça Gir apresentaram comprimento de cabeça 2,8cm maior (P<0,05) que as fêmeas da raça Nelore. O comprimento da orelha variou (P<0,05) conforme a base materna utilizada. As vacas com genes da raça Nelore são 5,0cm mais altas (P<0,05). O perímetro torácico foi a característica morfométrica que teve correlação fenotípica de elevada magnitude com o peso, acima de 0,70, para as fêmeas das bases maternas Gir, Nelore e Nelogir. A pelagem não é indicativa da base materna utilizada. As vacas F1 de base materna Gir tiveram estrutura corporal menor que as fêmeas que portam genes da raça Nelore.(AU)


F1 Holstein x Zebu females from different maternal bases were characterized regarding coat, depigmentation and morphometric characteristics. A total of 266 F1 female progenies from the crossbreeding of 26 Holstein bulls with females of Zebu genetic composition were used: Gir, Nellore, Guzonel, Nellogir. Frequency distribution analysis was applied for qualitative characteristics and dispersion measures and central tendency for morphometric characteristics, and means were compared by Tukey test at 5% probability. Over 60.0% of the animals had a black coat. The cows that originated from the Gir breed had a head length of 2.8cm (P<0.05) higher than the Nellore females. Ear length varied (P<0.05) according to the maternal base used. Cows with Nelore genes were 5.0cm taller (P<0.05). The thoracic perimeter was the morphometric characteristic that had a high magnitude phenotypic correlation with weight, above 0.70, for the females of the Gir, Nellore and Nellogir maternal bases. The coat is not indicative of the maternal base used. F1 Gir-based cows had a smaller body structure than females with Nellore genes.(AU)


Subject(s)
Animals , Female , Cattle , Phenotype , Body Weights and Measures/veterinary , Skin Pigmentation/genetics , Crosses, Genetic , Heredity/genetics
5.
Arq. bras. med. vet. zootec. (Online) ; 72(4): 1145-1153, July-Aug. 2020. tab, ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1131471

ABSTRACT

O presente estudo avaliou o perfil mineral de Cálcio (Ca), Cobre (Cu) e Zinco (Zn) no estojo córneo pré e pós-desmame e sua associação com pigmentação, gênero e idade de potros da raça Crioula criados em pastagens nativas no Rio Grande do Sul. Foram coletadas amostras do casco de potros da raça Crioula 41 dias pré e 28 dias pós-desmame. Os teores de Ca, Cu e Zn variaram no casco fetal (571,0±39,4; 14,5±7,6 e 130,0±30,5mg/kg, respectivamente; P<0,05) e no definitivo (653,0±169,2; 33,8±11,5 e 69,3±36,8mg/kg, respectivamente; P<0,05), no pré (620,0±184; 17,2±21,2 e 103,0±75,5mg/kg, respectivamente; P<0,05) e no pós-desmame (517,5±181; 0 e 79,0±41,7mg/kg, respectivamente; P<0,05). Houve associação positiva (P<0,05) com a faixa etária no pré-desmame para Ca (r=0,5) e Cu (r=0,57), e negativa para Zn (r=-0,69; P<0,05). No pós-desmame, houve associação positiva (P<0,05) para Ca (r=0,36) e Zn (r=0,64) e negativa para Cu (r=-0,39; P<0,05). Tanto a pigmentação quanto o gênero não afetaram o perfil mineral. Conclui-se que há diferenças nas concentrações de Ca, Cu e Zn na epiderme do casco de potros da raça Crioula no pré e pós-desmame, independentemente da pigmentação e do gênero, onde as concentrações de Ca e Cu aumentam com a idade, enquanto as de Zn diminuem.(AU)


The aim of this study was to evaluate the mineral profile of Ca, Cu and Zn in the hoof horny capsule at pre and post-weaning and its association with pigmentation, gender and age range of Crioulo foals raised in native pastures in RS. Samples were collected from the epidermis of the Crioulo foal's hoof at two times, 41 pre and 28 post-weaning. The contents of Ca, Cu, Zn Varied in the fetal hoof ( 571.0±139.4, 14.5±7.6 and 130.0±30.5mg/kg, respectively, P<0.05) and definitive (653.0±169.2, 33.8±11.5 and 69.3±36.8mg/kg, respectively, P<0.05), in the pre (620.0±184, 17.2±21.2 and103.0±75.5mg/kg, respectively, P<0.05) and post-weaning (517.5±181, 0.1 and 79.0±41.7mg/kg, respectively, P<0.05).There was a positive association (P<0.05) with a preweaning age for Ca (r=0.5) and Cu (r=0.57) and negative for Zn (r=-0.69, P<0.05). In the post weaning there was a positive association (P<0.05) for Ca (r=0.36) and Zn (r=0.64) and negative for Cu (r=-0.39; P<0.05). Neither pigmentation nor gender affected the mineral profile. It is concluded that there are differences in Ca, Cu, Zn concentrations in the epidermis of foals of the crioulo breed at the pre and post weaning, regardless of pigmentation and sex, where Ca and Cu concentrations increase with age, while Zn concentrations decrease.(AU)


Subject(s)
Animals , Skin Pigmentation/physiology , Hoof and Claw/cytology , Horses/growth & development , Minerals , Zinc , Calcium , Copper , Keratins
6.
Rev. cuba. salud pública ; 46(2): e1823, abr.-jun. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126867

ABSTRACT

Esta comunicación breve pretende aportar argumentos acerca de la importancia de considerar al color de la piel y al género como categorías que se intersecan en los análisis sobre determinación social en la salud. Para ello se ofrecen ejemplos de resultados investigativos previos, que ilustran el panorama contemporáneo en la Cuba de hoy. A la vez se problematiza sobre el pensamiento hegemónico en salud y se pondera aquel que caracteriza a la medicina social, con el fin de ubicar el enfoque socio-antropológico que reclaman estos temas(AU)


This brief communication is aimed at providing supporting ideas about the importance of considering skin color and gender as categories that are relevant for the analysis of social determinants of health. In view of that, we offer examples of previous research outcomes that show the contemporary situation in Cuba. At the same time, we approached the problem of hegemonic thinking in health, focusing on thinking as an aspect inherent in social medical care, in order to highlight the socio-anthropologic approach required for treating these topics(AU)


Subject(s)
Humans , Male , Female , Skin Pigmentation , Gender Equity , Cuba , Human Rights
7.
An. bras. dermatol ; 95(1): 46-51, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088734

ABSTRACT

Abstract Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or therapeutic investigation rather than animal and in vitro tests. Objective: Development of a cutaneous organoid culture model, aiming at the study of radiation-induced melanogenesis. Method: A validation study, which involved biopsies of the skin of the back of the adult ear. One sample was irradiated with different doses of UVB, UVA, or visible light (VL); the other was maintained in the dark for 72 h. The viability of the tissues was evaluated from the morphological and architectural parameters of the histology, and the expression of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, by real-time polymerase chain reaction (PCR). The radiation-induced melanin pigmentation was standardized according to the doses of each radiation and evaluated by digital image analysis (Fontana-Masson). Results: The primary skin culture was standardized at room temperature using DMEM medium. The doses of UVB, UVA, and VL (blue light) that induced differential melanogenesis were: 166 mJ/cm2, 1.524 J/cm2, and 40 J/cm2. The expression of the GAPHD constitutional gene did not differ between the sample of skin processed immediately after tissue collection and the sample cultured for 72 h in the standardized protocol. Study limitations: This was a preliminary study that evaluated only the viability and integrity of the melanogenic system, and the effect of the radiation alone. Conclusions: The standardized model maintained viable melanocytic function for 72 h at room temperature, allowing the investigation of melanogenesis induced by different forms of radiation.


Subject(s)
Humans , Adult , Ultraviolet Rays , Organoids/radiation effects , Cell Culture Techniques/standards , Light , Melanins/biosynthesis , Melanins/radiation effects , Radiation Dosage , Silver Nitrate , Time Factors , Biopsy , Skin Pigmentation/radiation effects , Gene Expression , Cells, Cultured , Reproducibility of Results , Real-Time Polymerase Chain Reaction
8.
Rev. ciênc. farm. básica apl ; 41: [11], 01/01/2020. graf, tab, ilus
Article in English | LILACS | ID: biblio-1128579

ABSTRACT

The skin is the largest and most exposed organ of the human body, therefore subject to diseases and alteration of its appearance. Among these alterations, the cutaneous hyperchromia may be cited. Currently, the market offers numerous products with depigmenting action to the treatment of such disorders. The aim of this work was to analyze depigmenting products commercialized in establishments in the city of Bento Gonçalves (RS, Brazil) and websites of cosmetic companies. It was found 45 products with depigmenting action and, from these, 59 different active agents were identified. The main active compounds found were kojic acid, arbutin, ascorbic acid, hydroquinone and glycolic acid. Another observed data was that in 78% of the studied products the active substances were being used in combination. The most used vehicles were also studied as a reference to the use of sunscreen in the treatment of cutaneous hyperchromia. The present work had identified in the market a variety of products with depigmentation action and, because of this, it aims to serve as a reference to the healthcare professionals, especially at the prescribing moment, looking for the best results, with regards to treatment efficiency and safety.(AU)


Subject(s)
Humans , Skin Pigmentation/drug effects , Hyperpigmentation/drug therapy , Cosmetics , Dermatologic Agents/analysis , Arbutin , Ascorbic Acid , Pyrones , Brazil , Drug Combinations , Glycolates , Hydroquinones
9.
Autops. Case Rep ; 10(4): e2020197, 2020. tab, graf
Article in English | LILACS | ID: biblio-1131843

ABSTRACT

Ochronosis is a cutaneous disorder caused by the accumulation of phenols, either endogenously as homogentisic acid in patients with alkaptonuria (autosomal recessive disorder with deficiency of the enzyme homogentisic acid oxidase), or exogenously in patients using phenol products such as topical creams containing hydroquinone or the intramuscular application of antimalarial drugs. Exogenous ochronosis (EO) typically affects the face and was reported in patients with dark skin such as Black South Africans or Hispanics who use skin-lightening products containing hydroquinone for extended periods. Recently more cases have been reported worldwide even in patients with lighter skin tones, to include Eastern Indians, Asians, and Europeans. However, just 39 cases of EO have been reported in the US literature from 1983 to 2020. Here we present two cases; a 69 and a 45-year-old female who were seen for melasma, given hydroquinone 4% cream daily and tretinoin 0.05%. Both patients noticed brown spots on their cheeks, which progressively enlarged and darkened in color. The diagnosis of ochronosis was confirmed by characteristic histopathological features on the punch biopsy. Unfortunately, neither patient responded to multiple treatments (to include, tazarotene 0.1% gel and pimecrolimus ointment, topical corticosteroids, and avoidance of hydroquinone containing products). We also present a case of classic (endogenous) ochronosis in a patient with alkaptonuria to picture the histological similarities of these two entities. EO is an important clinical consideration because early diagnosis and treatment may offer the best outcome for this notoriously refractory clinical diagnosis.


Subject(s)
Humans , Female , Middle Aged , Aged , Skin Pigmentation , Skin Cream/adverse effects , Ochronosis/diagnosis , Phenols , Skin , Skin Diseases , Cheek , Alkaptonuria , Homogentisic Acid
10.
Rev. latinoam. enferm. (Online) ; 28: e3362, 2020. tab
Article in English | LILACS, BDENF | ID: biblio-1139221

ABSTRACT

Objective: to evaluate and compare the self-esteem of young female university students aged between 18 and 24 years old according to race/skin color criteria. Method: a cross-sectional and quantitative study, developed with 240 undergraduate female students from a public Brazilian university. Data collection took place online through a structured questionnaire that included the participants' sociodemographic and lifestyle habits, and the Rosenberg Self-Esteem Scale. For data analysis, descriptive statistics, association test, and comparison of means were used. Results: most of the young women had a mean level of self-esteem. No statistically significant association was found among the "self-esteem level" and "self-reported skin color or race" variables. Conclusion: although no significant association was identified between self-reported skin color or race and level of self-esteem, young black women have lower mean self-esteem scores than young non-black women. Strategies that strengthen the self-esteem of young female university students are necessary to prevent harms to their physical and mental health, and, consequently, to their academic performance.


Objetivo: avaliar e comparar a autoestima de jovens universitárias com idade entre 18 e 24 anos segundo critério raça/cor. Método: estudo transversal, quantitativo, desenvolvido com 240 graduandas de uma universidade pública brasileira. A coleta de dados ocorreu de modo online através de um questionário estruturado que contemplava as características sociodemográficas e de hábitos de vida das participantes, e a Escala de Autoestima de Rosenberg. Para análise dos dados utilizou-se estatística descritiva, teste de associação e comparação de médias. Resultados: a maioria das jovens apresentou nível médio de autoestima. Não foi encontrada associação estatisticamente significativa entre as variáveis "nível de autoestima" e "cor ou raça autorreferida". Conclusão: embora não tenha sido identificada associação significativa entre cor ou raça autorreferida e nível de autoestima, jovens negras apresentam escores médios de autoestima inferiores ao de jovens não negras. Estratégias que fortaleçam a autoestima das jovens universitárias são necessárias para prevenir prejuízos à sua saúde física, mental, e, consequentemente, ao seu desempenho acadêmico.


Objetivo: evaluar y comparar la autoestima de jóvenes universitarias de entre 18 y 24 años en función de los criterios de raza/etnia. Método: estudio transversal, cuantitativo, desarrollado con 240 estudiantes universitarias de una universidad pública brasileña. La recopilación de datos se realizó online a través de un cuestionario estructurado que incluía los hábitos sociodemográficos y de estilo de vida de las participantes, y la Escala de Autoestima de Rosenberg. Para el análisis de datos, se utilizó estadística descriptiva, prueba de asociación y comparación de medias. Resultados: la mayoría de las mujeres jóvenes presentaban un nivel de autoestima promedio. No se encontró asociación estadísticamente significativa entre las variables "nivel de autoestima" y "etnia o raza autodeclarada". Conclusión: aunque no se identificó una asociación significativa entre la etnia o raza autodeclarada y el nivel de autoestima, las jóvenes negras presentan puntajes promedio de autoestima más bajos que las jóvenes no negras. Es necesario implementar estrategias que fortalezcan la autoestima de las jóvenes universitarias para evitar daños a su salud física, mental y, en consecuencia, a su rendimiento académico


Subject(s)
Humans , Female , Adolescent , Adult , Self Concept , Students , Universities , Brazil , Skin Pigmentation , Cross-Sectional Studies , Health Strategies , Continental Population Groups , Life Style
11.
Saúde Soc ; 29(1): e200018, 2020.
Article in Portuguese | LILACS | ID: biblio-1101911

ABSTRACT

Resumo Por meio de um exercício de walking ethnography, pretendemos apresentar uma etnografia da oferta cosmética destinada à despigmentação da pele no coração de Lisboa, focando num fragmento da cidade que junta diferentes propostas e produtos estéticos: spas chineses, salões de beleza e cabeleireiros africanos, lojas do comércio dito "étnico" ligado a imigrantes e portugueses descendentes de populações asiáticas ou africanas. Definimos esse passeio como "caminho do branqueamento" - parafraseando ironicamente o título de um dos mais famosos livros de Michael Jackson, Paths towards a clearing (1989). Considerando o corpo como um projeto em construção, pretendemos mostrar que os imaginários e os desejos ligados ao consumo desses tratamentos, assim como os padrões de beleza veiculados pelo marketing dos produtos de clareamento da pele, refletem e reproduzem variáveis sociais de género, classe e raça. Queremos também evidenciar como a maior parte dos produtos branqueadores, vendidos no centro da cidade, são proibidos pela legislação europeia de regulamentação de cosméticos, devido às altas concentrações de substâncias tóxicas. Essas substâncias, que circulam livremente nas redes do comercio informal, podem ser muito prejudiciais para a saúde dos consumidores, comportando severos riscos dermatológicos.


Abstract Through a walking ethnography exercise, we intend to present an ethnography of the cosmetic offer aimed at depigmenting the skin in the heart of Lisbon, focusing on a fragment of the city that brings together different proposals and aesthetic products: Chinese spas, beauty salons and African hairdressers, shops of the so-called "ethnic" trade linked to immigrants and Portuguese descendants of Asian or African populations. We defined this tour as a "whitening path" - ironically paraphrasing the title of one of Michael Jackson's most famous books, Paths towards a clearing (1989). Considering the body as a project under construction, we intend to show that the imaginary and desires related to the consumption of these treatments, as well as the beauty standards conveyed by the marketing of skin whitening products, reflect and reproduce social variables of gender, class and race. We also want to highlight how most whitening products, sold in the city center, are prohibited by European cosmetics regulation legislation due to the high concentrations of toxic substances. These substances - which circulate freely in the networks of informal commerce - can be very harmful to the consumers' health, carrying severe dermatological risks.


Subject(s)
Humans , Male , Female , Beauty , Skin Pigmentation , Cosmetics/standards , Esthetics , Cosmetic Industry , Anthropology, Cultural , Dermatology/legislation & jurisprudence , Dermatology/ethics
12.
Einstein (Säo Paulo) ; 18: eAO5432, 2020. tab, graf
Article in English | LILACS | ID: biblio-1133775

ABSTRACT

ABSTRACT Objective: To describe the morphology of the supra- and infraumbilical linea nigra in puerperal women. Methods: The study was conducted from September 2017 to April 2018, and included 157 puerperal women admitted for childbirth care at the Obstetrics Department of a public maternity hospital of the city of São Paulo (SP), Brazil. The abdomen of subjects was photographed on the first or second day postpartum, with the patient lying symmetrically in dorsal decubitus at a standardized distance. Contrast was slightly adjusted and the morphological pattern of supra and infraumbilical linea nigra in the proximity of the umbilical scar was characterized. The images were independently analyzed by two researchers and only the matching results from both observers were used. Results: Of the 157 observed cases, 139 (88.5%) images provided concordant results between the two researchers. Excluding 41 cases of absence or poor definition of the linea nigra, 98 images were analyzed. Supra- and infraumbilical linea nigra were analyzed separately and classified according to three directions (left, center and right of the umbilical scar). The combination of the supra- and infraumbilical images resulted in the formation of nine distinct patterns, being the most prevalent, in primiparous (72.2%) and multiparous women (50.0%), and the authors named as "anticlockwise spiralization of the linea nigra". Conclusion: The analysis of supra- and infraumbilical linea nigra in puerperal women showed a predominance of what the authors named "anti-clockwise spiralization of the linea nigra sign".


RESUMO Objetivo: Descrever a morfologia da linea nigra supra e infraumbilical em puérperas. Métodos: O estudo foi realizado no período de setembro de 2017 a abril de 2018 e incluiu 157 puérperas admitidas para o parto no Serviço de Obstetrícia de uma maternidade pública da cidade de São Paulo (SP). O abdome das pacientes foi fotografado no primeiro ou segundo dia pós-parto, com a paciente deitada simetricamente em decúbito dorsal a uma distância padronizada. O contraste foi ligeiramente ajustado, e o padrão morfológico da linea nigra supra e infraumbilical na proximidade da cicatriz umbilical foi caracterizado. As imagens foram analisadas independentemente por dois pesquisadores, e apenas os resultados concordantes dos dois observadores foram utilizados. Resultados: Dos 157 casos observados, 139 (88,5%) imagens apresentaram resultados concordantes entre os dois pesquisadores. Excluindo 41 casos de ausência ou má definição da linea nigra, 98 imagens foram analisadas. As linea nigra supra e infraumbilicais foram analisadas separadamente e classificadas de acordo com três direções (esquerda, centro e direita da cicatriz umbilical). A combinação das imagens supra e infraumbilicais resultou na formação de nove padrões distintos, sendo os mais prevalentes nas primíparas (72,2%) e multíparas (50,0%), o que os autores denominaram "espiralamento anti-horário da linea nigra". Conclusão: A análise das linea nigra supra e infraumbilical em puérperas mostrou predominância do que os autores denominaram "sinal do espiralamento anti-horário da linea nigra".


Subject(s)
Humans , Female , Skin/pathology , Umbilicus , Pregnancy/physiology , Skin Pigmentation , Hyperpigmentation/diagnosis , Brazil
13.
Einstein (Säo Paulo) ; 18: eAO4694, 2020. tab
Article in English | LILACS | ID: biblio-1039745

ABSTRACT

ABSTRACT Objective To determine the association among bone mineral content, sociodemographic, anthropometric and behavioral factors, and health status of Brazilian adults. Methods This was a cross-sectional, population-based study including 701 individuals from both sexes aged between 20 and 59 years. DEXA was used to evaluate dependent variable. The associations were evaluated using linear regression models stratified by sex. Results When mean bone mineral content values were compared, we found significant differences related to sex and all the independent variables evaluated. In the adjusted models, we identified an inverse association between bone mineral content and age in both sexes. Among men, to be overweight and/or obese, be highly educated, and have almost sufficiency of 25(OH)D were associated with higher bone mineral content values. On the other hand, among women, to be non-white skin color, overweight and/or obese were associated with better bone health. The main factors associated with low total bone mineral density were advanced age, white skin color, low level of formal education, eutrophy, and 25(OH)D deficiency. Conclusion Our results may help to identify adults who are at higher risk, and these findings should be used as guidelines for prevention and early diagnosis.


RESUMO Objetivo Verificar a associação entre o conteúdo mineral ósseo e fatores sociodemográficos, antropométricos, comportamentais e condições de saúde em adultos brasileiros. Métodos Estudo transversal, de base populacional, realizado com 701 indivíduos de ambos os sexos, com idade entre 20 e 59 anos. A variável dependente foi avaliada por DEXA. As associações foram avaliadas por modelos de regressão linear estratificados baseados no sexo dos indivíduos. Resultados Quando comparados os valores médios do conteúdo mineral ósseo, observamos diferença estatisticamente significante em relação aos sexos e para todas as variáveis independentes avaliadas. Nos modelos ajustados, identificamos associação inversa entre o conteúdo mineral ósseo e a idade em ambos os sexos. Entre os homens, sobrepeso e obesidade, alta escolaridade e suficiência de 25(OH)D foram associados a maiores valores de conteúdo mineral ósseo. Entre as mulheres, por sua vez, cor da pele não branca, sobrepeso e obesidade foram associados a melhor saúde óssea. Os principais fatores associados à baixa massa óssea total foram idade avançada, cor da pele branca, baixa escolaridade, eutrofia e deficiência de 25(OH)D. Conclusão Esses resultados podem auxiliar na identificação de adultos com maior risco e que devem ser alvo de medidas de prevenção e diagnóstico precoce.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Bone Density , Nutritional Status , Brazil , Skin Pigmentation , Exercise , Body Mass Index , Cluster Analysis , Sex Factors , Anthropometry , Cross-Sectional Studies , Surveys and Questionnaires , Risk Factors , Age Factors , Educational Status , Hydroxycholecalciferols/blood , Middle Aged
14.
Biol. Res ; 53: 04, 2020. tab, graf
Article in English | LILACS | ID: biblio-1089074

ABSTRACT

BACKGROUND: Pigmentation development, is a complex process regulated by many transcription factors during development. With the development of the RNA sequencing (RNA-seq), non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, are found to play an important role in the function detection of related regulation factors. In this study, we provided the expression profiles and development of ncRNAs related to melanocyte and skin development in mice with black coat color skin and mice with white coat color skin during embryonic day 15 (E15) and postnatal day 7 (P7). The expression profiles of different ncRNAs were detected via RNA-seq and also confirmed by the quantitative real-time PCR (qRT-PCR) method. GO and KEGG used to analyze the function the related target genes. RESULTS: We identified an extensive catalogue of 206 and 183 differently expressed miRNAs, 600 and 800 differently expressed lncRNAs, and 50 and 54 differently expressed circRNAs, respectively. GO terms and pathway analysis showed the target genes of differentially expressed miRNA and lncRNA. The host genes of circRNA were mainly enriched in cellular process, single organism process. The target genes of miRNAs were mainly enriched in chromatin binding and calcium ion binding in the nucleus. The function of genes related to lncRNAs are post translation modification. The competing endogenous RNA (ceRNA) network of lncRNAs and circRNAs displays a complex interaction between ncRNA and mRNA related to skin development, such as Tcf4 , Gnas , and Gpnms related to melanocyte development. CONCLUSIONS: The ceRNA network of lncRNA and circRNA displays a complex interaction between ncRNA and mRNA related to skin development and melanocyte development. The embryonic and postnatal development of skin provide a reference for further studies on the development mechanisms of ncRNA during pigmentation.


Subject(s)
Animals , Mice , Skin/embryology , Skin Pigmentation/genetics , Gene Expression Profiling , MicroRNAs/genetics , RNA, Long Noncoding/genetics , Melanocytes , Cell Differentiation , Real-Time Polymerase Chain Reaction
15.
Cad. Saúde Pública (Online) ; 36(10): e00121419, 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1132829

ABSTRACT

Abstract: Our study is based on the Colombia SABE survey (Health, Well-Being, and Aging Study), which included 23,694 individuals aged 60+ in urban and rural areas of the country. The analysis addresses adult self-perception of health status as a dependent variable and its relationships to ethnic/racial self-recognition and to interviewer-ascribed skin color as a phenotypic trait using a validated technique with a color palette. Social inequalities were determined based on the characterization of socioeconomic status, urban or rural residence, literacy, and the average years of education attained. Our study brought together socioeconomic factors, ethnic-racial self-recognition and skin color as factors of discrimination. Descriptive statistical tests and four adjusted logistic models were developed, controlling by the sex and the age of the individuals. The findings show that adults in households with better socioeconomic conditions have a better self-perception of health. Regarding ethnic-racial self-recognition, Afro-descendant, black, and mulatto adults have less good health perception than white-mestizo adults and face the worst socioeconomic conditions. In summary, skin color and ethnic and racial self-recognition categories, together with classic socioeconomic variables, are relevant to understand the health status self-perception of older adults as part of the processes of exclusion and discrimination that have consequences for health inequalities.


Resumen: Este estudio está basado en la encuesta Colombia SABE (Salud, Bienestar, y Estudio de Envejecimiento), que incluyó a 23.694 personas con 60 años o más en áreas urbanas y rurales del país. El análisis se dirige a la autopercepción del estado de salud que tienen los adultos, como variable dependiente y sus correlaciones con el autorreconocimiento étnico/racial, así como el color de piel adscrito por parte del entrevistador -como rasgo fenotípico-, usando una técnica validada mediante una gama de colores. Las inequidades sociales se determinaron basándose en la caracterización del estatus socioeconómico, residencia urbana o rural, alfabetización, y el promedio de años de educación completados. A través del análisis mencionado anteriormente, este estudio aunó factores socioeconómicos con el autorreconocimiento étnico-racial y el color de piel, como factor de discriminación. Se desarrollaron tests estadísticos descriptivos y cuatro modelos logísticos ajustados, que fueron desarrollados controlando sexo y edad de los participantes. Los resultados revelan que los adultos en los hogares con mejores condiciones socioeconómicas tuvieron una mejor autopercepción de salud. Respecto al autorreconocimiento étnico-racial, afrodescendiente, negro, y adultos mulatos, tienen una percepción menos buena de salud, en comparación con los adultos blancos-mestizos, además de enfrentar peores condiciones socioeconómicas. En resumen, color de piel, categorías étnicas, así como las raciales de autorreconocimiento, junto con las clásicas variables socioeconómicas, son relevantes para el autopercepción del estatus de salud de los adultos de edad avanzada, como parte de los procesos de exclusión y discriminación que tienen consecuencias, debido a las inequidades de salud.


Resumo: O artigo teve como base a pesquisa SABE (Saúde, Bem-Estar e Envelhecimento) da Colômbia, que incluiu 23.694 indivíduos com 60 anos ou mais nas áreas urbana e rural do país. A análise trata o autorrelato da saúde como variável dependente e as relações com o autorrelato étnico-racial e a cor da pele relatada pelo entrevistador enquanto traço fenotípico, através de uma técnica validada usando uma paleta de cores. As desigualdades sociais foram determinadas com base na caracterização da condição socioeconômica, residência urbana ou rural, alfabetização e anos de estudo. Através dessa análise, o estudo construiu fatores socioeconômicos com autorrelato étnico racial e cor da pele como fator de discriminação. Foram desenvolvidos testes estatísticos descritivos e quatro modelos logísticos, ajustados por sexo e idade. Os achados mostram que adultos com melhores condições socioeconômicas apresentam melhor autorrelato da saúde. Com relação ao autorrelato étnico-racial, os adultos afrodescendentes, negros e mulatos apresentam, em média, pior autorrelato da saúde quando comparados aos adultos brancos e mestiços, além de piores condições socioeconômicas. Em resumo, as categorias de cor e de autorrelato étnico e racial, junto com variáveis socioeconômicas tradicionais, são relevantes para compreender o autorrelato da saúde dos idosos como parte dos processos de exclusão e discriminação que têm consequências para as desigualdades em saúde.


Subject(s)
Humans , Aged , Skin Pigmentation , Socioeconomic Factors , Brazil , Cross-Sectional Studies , Colombia , Middle Aged
16.
Annals of Dermatology ; : 159-163, 2020.
Article in English | WPRIM | ID: wpr-811080

ABSTRACT

Happle-Tinschert syndrome is a rare disease characterized by unilateral, segmentally arranged basaloid follicular hamartoma (BFH) with osseous, dental, and cerebral anomalies. Although BFH has been demonstrated to be associated with mutations in the patched gene, the genetic basis for Happle-Tinschert syndrome is still unknown. We describe a case of Happle-Tinschert syndrome in a 26-year-old female. The patient presented with unilateral skin color change to brownish papules and atrophoderma following the development of Blaschko's lines, plantar pitting, and nail dystrophy on the right side of the body. She also had scoliosis, hemihypotrophy, and dental anomalies. The skin lesions were histologically confirmed as BFHs. Next-generation sequencing of the patient's genomic DNA obtained from a peripheral blood sample identified no pathogenic mutation. This case illustrates the characteristic clinical features of Happle-Tinschert syndrome. Thus far, 14 cases of Happle-Tinschert syndrome have been reported, and we report another case of this syndrome.


Subject(s)
Adult , DNA , Female , Hamartoma , Humans , Rare Diseases , Scoliosis , Skin , Skin Pigmentation
17.
Fisioter. Bras ; 20(3): 442-447, Junho 11, 2019.
Article in Portuguese | LILACS | ID: biblio-1281363

ABSTRACT

As estrias são atrofias cutâneas lineares derivadas de um processo cicatricial. Elas se formam quando a tensão do tecido provoca uma lesão do conectivo dérmico, ocasionando uma dilaceração das malhas, gerando a perda da elasticidade e da compactação. A micropigmentação, também conhecida como dermopigmentação, dermografia, dermatografia ou tatuagem é uma técnica que consiste em um procedimento minimamente invasivo, utilizado para implantar pigmento na camada subepidérmica, para corrigir pequenas anormalidades ou para fins estéticos. O objetivo deste trabalho foi verificar a eficácia da camuflagem de cicatrizes de estrias por meio da micropigmentação. Após aplicação da sessão de micropigmentação foi verificado melhora da aparência das estrias na voluntária que seguiu corretamente as orientações. (AU)


Striae are linear cutaneous atrophies derived from a cicatricial process, they are formed when the tissue tension causes a lesion of the dermal connective, causing a tear of the meshes, generating the loss of elasticity and compression causing an injury. Micropigmentation, or also known as dermopigmentation, dermography, dermatography, or tattooing is a technique that consists of a minimally invasive procedure, used to implant pigment in the subepidermal layer, to correct small abnormalities or for aesthetic purposes. The objective of this case study was to verify the efficacy of the camouflage of scars by micropigmentation. After application of the micropigmentation session, it was verified an improvement in the appearance of the striae in the volunteer who followed the guidelines correctly. (AU)


Subject(s)
Humans , Female , Skin Pigmentation , Striae Distensae , Skin , Tattooing , Efficacy , Cicatrix
18.
Rev. cir. traumatol. buco-maxilo-fac ; 19(1): 22-25, jan.-mar. 2019. tab
Article in Portuguese | LILACS, BBO | ID: biblio-1254108

ABSTRACT

Esse estudo teve como objetivo identificar e classificar os sulcos das impressões labiais obtidas, e estabelecer relação entre os tipos de sulcos presentes nas impressões labiais e o fenótipo cor da pele e o sexo. A amostra foi composta por 60 estudantes de graduação do curso de Odontologia, de ambos os sexos. Para determinação e classificação dos sulcos labiais (Tipos I, I', II, III, IV e V), fez-se uso de amostras individuais de batons para tomada das impressões em suporte de cartolina branca. O sulco labial mais comum encontrado foi o Tipo I, seguido pelo Tipo II e pelo Tipo I'. Nos sexos feminino e masculino, o Tipo I e Tipo II foram os padrões dominantes. Os sulcos do Tipo II e I` foram predominantes em melanodermas; nos faiodermas e leucoderma, no entanto, os padrões predominantes foram os Tipos I e II. Pode-se concluir que a análise da impressão labial tem o potencial para o reconhecimento do gênero de um indivíduo, embora requeira um estudo detalhado para a realização correta do queilograma... (AU)


The aim of this study was to identify and classify the grooves of lip prints obtained, and establish a relationship between the types of labial grooves present on the prints and the phenotype of skin color and gender. The sample consisted of 60 graduate students, of both sexes. For determination and classification of lip grooves (Types I, I', II, III, IV and V), individual lip printing taken from lipsticks on white cardboard were used. The most common labial groove found, according to the classification proposed by Suzuky and Tsuchihaschi (1970), was type I, followed by Type II and Type I'. In females and in males, Type I and II were the dominant patterns. The grooves of the type II and I' were prevalent in melanoderm, in faioderm and in Caucasian the predominants patterns were types I and II. It can be concluded that lip print analysis has the potential for the recognition of the gender of an individual, but requires a detailed study to correctly perform the cheilogram... (AU)


Subject(s)
Humans , Male , Female , Phenotype , Printing , Reference Standards , Skin Pigmentation , Forensic Dentistry , Gender Identity , Lip , Classification , Color
19.
An. bras. dermatol ; 94(2): 172-181, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001149

ABSTRACT

Abstract BACKGROUND: Excessive sun exposure is the major risk factor for skin cancer. Thus, sun exposure behavior is the major focus for prevention of this disease, since it is potentially modifiable. Increasing the knowledge on sun related habits and other skin cancer risk factors is fundamental in the development of preventive programs, especially when directed to young people. OBJECTIVES: To assess the photoprotection habits and the knowledge about skin cancer in college students. METHODS: We conducted a cross-sectional study from Oct. 16 to Feb. 17, including 371 students from the Federal University of Santa Maria, RS, Brazil, through a self-administered questionnaire. RESULTS: The level of knowledge about skin cancer and photoprotection was unsatisfactory in more than 10% of the students. The occurrence of sunburn was extremely high among students, and 25% reported at least one episode of second degree sunburn. Proper use of sunscreen was referred by only 34% of individuals. Students who reported having received photo education in college were associated with a more consistent use of sunscreen. STUDY LIMITATIONS: health area represented a large part of the sample; instrument validated outside Brazil. CONCLUSIONS: Young people are unaware of basic information about sun protection and exposure. Even among those with proper knowledge, the use of photoprotective measures is very low. The sun exposure has shown to be excessive in most of the students, which makes this population an important target for photo-educational measures.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Students/psychology , Sunlight , Health Knowledge, Attitudes, Practice , Environmental Exposure/statistics & numerical data , Habits , Skin Neoplasms/prevention & control , Sunburn/prevention & control , Sunscreening Agents/therapeutic use , Brazil , Skin Pigmentation , Cross-Sectional Studies , Surveys and Questionnaires/statistics & numerical data
20.
São Paulo; s.n; 2019. 115 p. ilust, tabelas, quadros.
Thesis in Portuguese | LILACS, Inca | ID: biblio-1179193

ABSTRACT

INTRODUÇÃO: O lentigo maligno (LM) é o subtipo do melanoma mais comum da face. O LM apresenta-se clinicamente como uma mácula acastanhada na sua fase inicial, sendo difícil sua diferenciação com lesões pigmentadas benignas da face ao exame clínico. A face, por apresentar particularidades anatômicas e histológicas, pode dificultar o diagnóstico do LM ao diferenciá-lo dos seus simuladores (ceratose actínica pigmentada, ceratose líquen plano-like, lentigo solar, ceratose seborreica). A microscopia confocal in vivo (MC) auxilia no diagnóstico das lesões dermatológicas em que a dermatoscopia possui limitação, permitindo assim, aumentar a acurácia diagnóstica e evitar procedimentos invasivos em lesões benignas, de maneira desnecessária. OBJETIVOS: Descrever as alterações celulares e arquiteturais significativas no exame de MC nas lesões isoladas da face para o diagnóstico de melanoma. Elaborar um método diagnóstico acurado utilizando os critérios da microscopia confocal. MÉTODOS: Estudo prospectivo e retrospectivo com amostragem não aleatória consecutiva no qual foram incluídos 105 pacientes com lesões pigmentadas solitárias da face provenientes do Núcleo de Câncer de Pele A.C.Camargo Cancer Center. Critérios avaliados na MC: padrão em "favo de mel" típico ou atípico; células dendríticas; células nucleadas redondas; disseminação pagetóide, Sheets of cells; ninhos celulares densos e homogêneos (típico) ou denso e esparsos, com atipias (atípico); célula nucleada redonda ou dendrítica na junção dermo-epidérmica; células dendríticas foliculares (célula dendrítica no epitélio folicular) e cords ou projeções bulbosas; ilhas tumorais e fendas. O teste Exato de Qui Quadrado foi aplicado aos critérios da MC. Regressão Logística Univariada foi realizada através de estimativas de risco pelo Odds Ratio. Foi realizado a Regressão Logística Múltipla, resultando em um Nomograma para quantificar, em porcentagem, a chance de ter o diagnóstico de melanoma de acordo com a presença, singular ou concomitante, dos critérios da microscopia confocal supracitados. RESULTADOS: Os critérios da MC célula redonda atípica nucleada na epiderme, célula dendrítica nucleada na epiderme, disseminação pagetóide, célula atípica na JDE, ninhos juncionais atípicos, célula dendrítica folicular, sheets of cells e ilhas tumorais ou silhuetas escuras apresentaram significância estatística (p<0,05). Enquanto que os critérios cords ou projeções bulbosas e padrão em favo de mel atípico não tiveram significância. O único critério que apresentou-se como fator protetor pelo odds ratio foi a presença de ilhas tumorais ou silhuetas escuras. A Regressão Logística Múltiplo resultou em 3 critérios: célula redonda nucleada na epiderme, disseminação pagetóide e célula dendrítica folicular. A partir destes dados, foi realizado o nomograma para definir a chance, em percentual, de ter o diagnóstico de melanoma de acordo com a presença ou ausência das alterações celulares encontradas na microscopia confocal. A presença destes 3 critérios concomitantes expressa 98% de probabilidade da lesão ser melanoma. CONCLUSÃO: Este estudo viabilizou uma estimativa de probabilidade por intermédio de um percentual executável para o referido diagnóstico de melanoma da face, de acordo com a presença, ausência e concomitância destes critérios, de maneira prática e factível à aplicação no cotidiano do consultório


INTRODUCTION: Lentigo maligna (LM) is the most common subtype of facial melanoma. LM presents clinically as a brownish macule in its initial phase, and it is a challenge to differentiate from others facial benign pigmented lesions. Anatomical and histological face's features may make difficult to diagnose LM and to distinguish it from its simulators (actinic keratosis, lichen planus-like queratosis, solar lentigo, seborrheic keratosis). In vivo reflectance confocal microscopy (RCM) assists in the diagnosis of dermatological lesions in which dermatoscopy is limited, allowing to increase diagnostic accuracy and avoid invasive procedures in benign lesions, unnecessarily. OBJECTIVES: Describe cellular and architectural characteristics that were significant in the RCM examination in lesions face for the diagnosis of melanoma. Also elaborate an accurate diagnostic method using the criterias of RCM. METHODS: A prospective and retrospective study with consecutive non-random sampling with 105 patients presenting solitary pigmented facial lesions from the A.C.Camargo Cancer Center Skin Center. RCM criteria: typical or atypical honeycomb; dendritic cells; round nucleated cells; pagethoid spread, Sheets of cells; nests dense and homogeneous (typical) or dense and sparse (atypical); round or dendritic nucleated cell at the dermo-epidermal junction; follicular dendritic cells (dendritic cell in the follicular epithelium) and bulbous cords or projections; tumor islands and dark silluets. The exact test of Chi Square was applied to the criteria of RCM. Univariate Logistic Regression was performed through risk estimates by the Odds Ratio. Multiple Logistic Regression model was performed, resulting in a Nomogram to quantify, in percentage, the chance of having the diagnosis of melanoma according to the singular or concomitant presence of the above mentioned RCM criteria. RESULTS: RCM criteria atypical round cell nucleated in the epidermis, nucleated dendritic cell in the epidermis, pagethoid spread, atypical cell in the JDE, atypical junctional nodes, follicular dendritic cell, sheets of cells and tumor islands or dark silhouettes presented statistical significance (p <0.05). While the criteria cords or projections bulbous and standard in atypical honeycomb had no significance. The only criterion that presented itself as a protective factor by odds ratio was tumor islands or dark silhouettes. The Multiple Logistic Regression resulted in 3 criteria: nucleated round cell in the epidermis, pagetoid spread and follicular dendritic cell. From these data, the nomogram was used to define the percentage chance of having the diagnosis of melanoma according to the presence or absence of cellular alterations found in RCM. The presence of these 3 concomitant criteria expresses 98% probability of the lesion being a melanoma. CONCLUSION: This study enabled estimate probability for the diagnosis of facial melanoma, according to the presence, absence and concomitance of RCM criteria, in a practical and feasible way to the daily medical practice


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Skin Pigmentation , Hutchinson's Melanotic Freckle , Microscopy, Confocal , Melanoma/diagnosis , Prospective Studies , Retrospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL