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An. bras. dermatol ; 94(6): 744-746, Nov.-Dec. 2019. graf
Article in English | LILACS (Americas) | ID: biblio-1054899


Abstract This report describes a case of unusual deep skin ulcers with tortuous sinus tract formation in an immunocompetent woman. She was initially diagnosed with a Staphylococcus aureus skin infection and histopathologically diagnosed with pyoderma gangrenosum. However, culture from the deep end of ribbon gauze inserted into the subcutaneous sinus tract revealed shiny, light-yellow mucoid colonies, which were identified as Cryptococcus neoformans var. grubii. She was treated with fluconazole for nine months and completely healed. Cryptococcosis is an opportunistic infection caused by variants of C. neoformans species. Cutaneous manifestations of cryptococcosis are quite divergent, rarely occurring as deep skin ulcers with sinus formation.

Humans , Female , Adult , Skin Ulcer/microbiology , Skin Ulcer/pathology , Cryptococcosis/pathology , Cryptococcus neoformans/isolation & purification , Dermatomycoses/pathology , Immunocompetence , Skin Ulcer/drug therapy , Fluconazole/therapeutic use , Immunocompromised Host , Cryptococcosis/microbiology , Cryptococcosis/drug therapy , Dermatomycoses/microbiology , Dermatomycoses/drug therapy , Antifungal Agents/therapeutic use
An. bras. dermatol ; 91(5,supl.1): 60-63, Sept.-Oct. 2016. tab, graf
Article in English | LILACS (Americas) | ID: biblio-837947


Abstract Lucio’s phenomenon is an uncommon reaction characterized by severe necrotizing cutaneous lesions that occurs in patients with Lucio’s leprosy and lepromatous leprosy. It is considered by some authors as a variant of type 2 or 3 reaction. Death can occur because of blood dyscrasia or sepsis. Precipitating factors include infections, drugs and pregnancy. We report a 31-year-old female patient exhibiting both clinical and histopathological features of lepromatous leprosy and Lucio’s phenomenon presenting favorable response to treatment. We complement our report with a literature review of the Brazilian cases of Lucio’s phenomenon published in Portuguese and English.

Humans , Female , Adult , Skin Ulcer/pathology , Leprosy, Lepromatous/pathology , Skin/pathology , Skin Ulcer/drug therapy , Biopsy , Severity of Illness Index , Brazil , Leprosy, Lepromatous/drug therapy , Treatment Outcome , Necrosis
Rev. bras. cancerol ; 61(4): 373-379, out./dez. 2015.
Article in Portuguese | LILACS (Americas) | ID: biblio-847140


Introdução: Feridas tumorais (FT) são formadas pela infiltração de células malignas na estrutura da pele, havendo perda da solução de continuidade cutânea em virtude da proliferação celular descontrolada. Sinais e sintomas como odor, dor, sangramento, exsudato e prurido são observados com frequência. Objetivo: Descrever as intervenções de enfermagem empregadas para minimizar sinais e sintomas da FT. Relato de casos: Dois pacientes com FT foram acompanhados para avaliação quanto ao estadiamento da ferida e controle de sinais e sintomas. Diferentes coberturas foram utilizadas nos curativos, de acordo com a demanda de cada FT. Para controle do odor, utilizaram-se carvão ativado, clorexidina degermante e metronidazol. O manejo do exsudato foi realizado por meio do uso de alginato de cálcio e sódio em fibra e curativos absortivos com carvão ativado. O sangramento era controlado com alginato de cálcio e sódio em fibra e gaze embebida em petrolato. A dor foi mensurada e controlada por meio de analgesia. Conclusões: As FT apresentam características peculiares e necessitam de atenção especializada. A associação de coberturas nos curativos possibilitou minimizar sinais e sintomas.

Introduction: Fungating wounds (FW) are formed by the infiltration of malignant cells in the skin structure, with local invasion, which occurs as the result of uncontrolled cell proliferation. The signs and symptoms such as odor, pain, bleeding, itching and exudate are observed with great frequency. Objectives: This study aimed to describe the nursing interventions employed to decrease the signs and symptoms of FW. Cases report: This is a series of two cases followed during the dressing change for evaluating FW in relation to staging and symptoms. Different dressings were used according to the characteristics of each FW. The odor was controlled with charcoal dressings, chlorhexidine gluconate 4% and metronidazole. To absorb and contain exudate, we used calcium and sodium alginate fiber and absorptive dressings with charcoal. The bleeding was controlled with sodium and calcium alginate fiber and petrolatum gauze. The pain was measured and controlled by analgesia. Conclusion: FW have individual characteristics and need specialized attention. The association between distinct dressing choices can decrease signs and symptoms.

Introducción: Úlceras tumorales (UT) se forman por la infiltración de células malignas en la estructura de la piel, con pérdida de la solución de continuidad de la piel debido a la proliferación celular. Los signos y síntomas más comunes son mal olor, dolor, sangrado, comezón y exudado. Objetivo: Este estudio tuvo como objetivo describir las intervenciones de enfermería para reducir los signos y síntomas de HT. Reporte de Casos: Dos pacientes fueron acompañados para la evaluación en relación al estado previo de la úlcera y el control de señales y síntomas. Diferentes apósitos se han utilizado según las características de cada UT. Para el control del mal olor se usó apósitos de carbón con plata, degermante clorhexidina y metronidazol. Se utilizó la fibra de alginato de calcio y sodio y apósitos absorbentes con carbón activado en la contención y absorción del exudado. El sangrado se controló con fibra de alginato de sodio y calcio y gasa con petrolatum. El dolor se midió y se controló con la analgesia. Conclusión: Las UT tienen características particulares y la necesitan de una atención especializada. La asociación entre distintos productos en el tratamiento de las úlceras tumorales puede reducir los signos y síntomas.

Humans , Male , Female , Oncology Nursing/methods , Skin Ulcer/complications , Skin Ulcer/drug therapy , Skin Ulcer/nursing , Pain/prevention & control , Palliative Care
An. bras. dermatol ; 90(3,supl.1): 101-103, May-June 2015. ilus
Article in English | LILACS (Americas) | ID: lil-755746



The granulomatosis with polyangiitis, initially known as Wegener's granulomatosis, is a small and medium vessels vasculitis. It's classic form presents a triad: necrotizing granuloma of respiratory tract, necrotizing cutaneous vasculitis and glomerulonephritis. This vasculitis has cytoplasmic antineutrophil antibodies as signal. This work illustrates a case, of multisystemic rare disease, in which the segment and treatment were considered satisfactory for symptoms remission.


Adolescent , Female , Humans , Granulomatosis with Polyangiitis/pathology , Skin Ulcer/pathology , Adrenal Cortex Hormones/administration & dosage , Facial Dermatoses/drug therapy , Facial Dermatoses/pathology , Granulomatosis with Polyangiitis/drug therapy , Leg Dermatoses/drug therapy , Leg Dermatoses/pathology , Necrosis/pathology , Skin Ulcer/drug therapy , Terminology as Topic
An. bras. dermatol ; 89(5): 822-824, Sep-Oct/2014. graf
Article in English | LILACS (Americas) | ID: lil-720787


The livedoid vasculopathy is an obstructive vascular process of etiology not yet fully known, being possibly associated with several prothrombotic events. It is clinically characterized by the presence of painful and recurring purpuric lesions, which usually suffer ulceration and evolve with formation of white atrophic scars usually located in the lower limbs. Two cases are here reported of painful ulcerated lesions on the lower limbs, in which the identification of VL enabled the diagnosis of systemic diseases.

Adult , Female , Humans , Livedo Reticularis/pathology , Skin Ulcer/pathology , Livedo Reticularis/drug therapy , Skin Ulcer/drug therapy , Treatment Outcome , Venous Thrombosis/drug therapy , Venous Thrombosis/pathology
An. bras. dermatol ; 89(4): 657-659, Jul-Aug/2014. graf
Article in English | LILACS (Americas) | ID: lil-715542


Acne fulminans is a rare and serious condition characterized by the sudden onset of nodular and ulcerative acne lesions associated with systemic symptoms. It has been recognized a subset of patients with a sudden worsening of acne, often during treatment with oral isotretinoin, but without the strong presence of systemic involvement. Recognized by some authors as "pseudo-acne fulminans" or " acne fulminans sine fulminans," we report a case with these features in order to draw attention to the recognition and early management of this manifestation.

Adolescent , Humans , Male , Acne Vulgaris/drug therapy , Dermatologic Agents/administration & dosage , Isotretinoin/administration & dosage , Acne Vulgaris/chemically induced , Dermatologic Agents/adverse effects , Glucocorticoids/administration & dosage , Isotretinoin/adverse effects , Prednisone/administration & dosage , Skin Ulcer/drug therapy , Treatment Outcome
Rev. APS ; 16(4)dez. 2013.
Article in Portuguese | LILACS (Americas) | ID: lil-718804


O relato apresenta a experiência de discentes e docentes do Curso de Enfermagem da Universidade Federal de São João Del Rei, em um projeto de extensão para a implantação de um protocolo municipal de assistência aos portadores de úlceras crônicas. Apesar de as úlceras afetarem uma parcela significativa da população e, consequentemente e, onerarem o gasto público com a realização de curativos diários, a maioria dos municípios brasileiros, incluindo o município do estudo ? Divinópolis/MG, não há atenção sistematizada ao portador de úlceras nem protocolo de atendimento formalizado que contribua para a qualidade da assistência e o uso adequado de produtos. A partir disso, desenvolveu-se o projeto, que foi elaborado com a finalidade de implantação da sistematização do cuidado ao portador de úlceras crônicas, partindo-se do pressuposto que o curativo com coberturas especiais, acompanhado de um protocolo assistencial, é mais efetivo por diminuir o custo final de tratamento de feridas, reduzir os impactos negativos da doença e por diminuir o tempo de cicatrização. Para isso, foi selecionada uma unidade básica de saúde para funcionar como piloto do estudo. Foram cadastrados 12 portadores de úlceras e todos foram submetidos à avaliação completa do estado de saúde, avaliação minuciosa da lesão e tratamento com curativo adequado. As intervenções e orientações seguiram as necessidades do indivíduo e a etiologia da úlcera. O projeto ainda desenvolveu capacitações aos profissionais de saúde da rede pública municipal sobre a abordagem ao portador de úlceras crônicas.

The report presents the experience of students and teachers in the Nursing Program, Federal University of São João Del Rei, in an Extension Project to implement a municipal assistance protocol for patients with chronic ulcers. Although ulcers affect a significant portion of the population and therefore place a burden on public spending - with the application of daily dressings, in most Brazilian municipalities, including the city of the study ? Divinópolis/MG, there is no systematic attention to patients with ulcers, nor a formalized care protocol that contributes to the quality of care and the proper use of products. Based on this situation, the Project was developed, being designed for the purpose of implementing systematic of care for patients with chronic ulcers, starting from the assumption that the dressing with special bandages, accompanied by a care protocol, is a more effective approach, by reducing the final cost of treatment of lesions, reducing the negative impacts of the disease, and by reducing the healing time. For this, we selected a basic health unit to function as a pilot study. Twelve patients with ulcers were enrolled and all underwent a full health status assessment, a thorough evaluation of the lesion, and treatment with appropriate dressings. The interventions and guidance followed the needs of the individual, and the etiology of the ulcer. The Project has even developed training for healthcare professionals in the municipal public network on the treatment of patients with chronic ulcers.

Skin Ulcer , Wound Healing , Skin Ulcer/drug therapy , Nursing Care
J. bras. med ; 101(4): 13-18, jul.-ago. 2013. ilus
Article in Portuguese | LILACS (Americas) | ID: lil-699659


O fenômeno de Raynaud (FRy) caracteriza-se por episódios reversíveis de vasoespasmos de extremidades, que ocorrem usualmente após estresse ou exposição ao frio. O FRy pode ser primário ou secundário a uma série de condições, principalmente a doenças do espectro da esclerose sistêmica (ES). Na ES, o FRy costuma ser mais grave, e lesões isquêmicas de extremidades são frequentes. Nos últimos anos, avanços no estudo da fisiopatologia do FRy e da doença vascular na ES propiciaram o surgimento de novas opções terapêuticas para esta manifestação. Os bloqueadores de canal de cálcio devem ser utilizados como tratamento de primeira escolha para o FRy. Novas drogas, como os inibidores da fosfodiesterase V e os prostanoides, podem ser utilizados em pacientes com FRy grave, e a bosentana (antagonista do receptor da endotelina-1) é indicada para a prevenção de úlceras digitais recorrentes.

Raynaud's phenomenon (RP) is characterized by episodic vasospasm of the extremities, usually in response to stress or cold exposure. It can be primary or secondary to several conditions, especially systemic sclerosis-related diseases. In systemic sclerosis (SSc), RP is usually more severe and digital ischemic lesions are a frequent problem. In recent years, advances in the understanding of the pathophysiology of RP and of SSc vasculopathy led to the development of new therapeutic options for this condition. Calcium-channel blockers are the first choice for the treatment of RP. New drugs including phosphodiesterase type V inhibitors and prostanoids can be used for severe RP, and bosentan (endothelin-1 receptor antagonist) for prevention of recurrent digital ulcers.

Humans , Male , Female , Raynaud Disease/physiopathology , Raynaud Disease/drug therapy , Scleroderma, Systemic/physiopathology , Scleroderma, Systemic/drug therapy , Microscopic Angioscopy/methods , Autoantibodies , Calcium Channel Blockers/therapeutic use , Vascular Diseases/physiopathology , /therapeutic use , Receptors, Endothelin/antagonists & inhibitors , Skin Ulcer/prevention & control , Skin Ulcer/drug therapy , Vasodilator Agents/therapeutic use
Bol. malariol. salud ambient ; 51(1): 25-33, jun. 2011. tab
Article in Spanish | LILACS (Americas) | ID: lil-630453


En Venezuela se utiliza la inmunoterapia por su bondad terapéutica y operacional en el tratamiento de la leishmaniasis cutánea y se aprecian diferencias de su efectividad entre los servicios locales de salud que la emplean. En el estado Mérida, donde se tiene un bajo nivel de falla terapéutica, se desconocen los factores de riesgo ó de protección que la determinan. Por ello se planteó realizar un estudio epidemiológico de casos y controles para evaluar los factores individuales demográficos, clínicos, inmunológicos y adherencia terapéutica que influyen en dicha efectividad. El ajuste con regresión logística determinó según definición: a) Demográfica: como riesgo las edades extremas, tabaquismo y de oficio doméstico, con protección en el alfabeto educativamente, b) Clínica: como riesgo la forma intermedia, cinco o más lesiones, infección secundaria y ubicación en pié, con protección en la forma localizada y tamaño menor a 60 mm, c) Inmunológica: de riesgo las bajas respuestas a leishmánina y PPD, d) Adherencia terapéutica: son riesgo la aplicación tópica y aseo local inadecuados. Se concluye, hay factores de riesgo y protección que modelan la eficacia de la inmunoterapia, lo que en consecuencia demanda una dinámica vigilancia clínico-epidemiológica para potenciar dicha terapéutica.

Immunotherapy is used in Venezuela as treatment of cutaneous leishmaniasis and there are differences among the health services that use it. In Merida State there are a low proportion of failures, but the factors that are related to this failure are unknown. A case-control study was planned to evaluate the demographics, clinical, immunological factors and the treatment compliance that can be related to the effectiveness. Logistic regression showed that the factors related to failure were: a) demographics: lower and older ages, smoking, domestic labor and illiteracy; b) clinical: intermediate leishmaniasis, five or more lesions, aggregated infection, lesions in feet, and lesion size above 60 mm; c) Immunology: low reactivity to Montenegro and tuberculin tests; d) treatment compliance: use of incorrect topical substances and inadequate cleaning of ulcer. As a conclusion, there are several factors that influence treatment response, that require clinical and epidemiological surveillance to increase the effect of therapy.

Humans , Male , Female , Leishmaniasis, Cutaneous/epidemiology , Leishmaniasis, Cutaneous/ethnology , Leishmaniasis, Cutaneous/immunology , Leishmaniasis, Cutaneous/prevention & control , Leishmaniasis, Cutaneous/drug therapy , Immunotherapy , Skin Ulcer/epidemiology , Skin Ulcer/parasitology , Skin Ulcer/prevention & control , Skin Ulcer/drug therapy
Acta cir. bras ; 23(3): 262-269, May-June 2008. ilus, graf
Article in English | LILACS (Americas) | ID: lil-484387


PURPOSE: The aim of the study was to determine the effect of a combination of medium chain triglycerides (caprylic, capric, caproic and lauric acids), linoleic acid (essential fatty acid), vitamins A and E and soy lecithin, through a morphometric study, on the wound healing kinetics of experimental cutaneous ulcers. METHODS: A total of 45 male Wistar rats were used, in which a skin flap of total thickness with an area of 4 cm² was removed. The animals were divided randomly into 3 groups of 15 rats each, Control, Reference and Test groups, which were treated topically with 0.9 percent NaCl, a preparation of clostebol combined with neomycin sulfate and the test formulation, respectively. The wound areas were measured by digital planimetry at days zero, 3, 7 and 12 postoperative. Based on the wound area, we determined the degree of tissue repair and mean rate of repair at different time intervals. RESULTS: At day 3, an expansion of the wound area was observed in the Reference group and slight contraction in the Control and Test groups. On the subsequent days, the healing process, according to the degree of repair, proceeded in a linear manner, such that, at day 12, the healed area reached 77.95 percent of the initial ulcerated region in the Control group, 78.40 percent in the Reference group and 83.49 percent in the Test group, showing no significant differences. The overall mean rate of repair was equally similar at 12 days of treatment: 25.79 mm²/dia in the Control group, 25.42 mm²/dia in the Reference group and 27.38 mm²/dia in the Test group. CONCLUSION: The test preparation, applied topically on the experimentally induced cutaneous ulcers in rats, did not accelerate the process of tissue repair by secondary union.

OBJETIVO: Avaliar o efeito da associação de triglicerídeos de cadeia média (ácidos caprílico, cáprico, capróico e láurico), ácido linoléico (ácido graxo essencial), vitaminas A e E e lecitina de soja, através de estudo morfométrico, na cinética de reparação de úlceras cutâneas experimentais. MÉTODOS: Utilizaram-se 45 ratos, machos, da linhagem Wistar, nos quais foi removido um retalho cutâneo de espessura total com 4 cm² de área. Os animais foram divididos aleatoriamente em 3 grupos constituídos de 15 ratos, Controle, Referência e Teste, que foram tratados por via tópica respectivamente, com solução salina 0,9 por cento, composto de clostebol associado a sulfato de neomicina e a formulação em teste. As áreas das feridas foram mensuradas por planimetria digital nos dias zero, 3, 7 e 12 de pós-operatório. A partir da área da ferida, calcularam-se ainda o grau de reparação e a taxa média de reparação em intervalo de tempo. RESULTADOS: No 3o dia observou-se uma expansão da área da ferida no grupo referência e uma leve contração nos grupos controle e teste. Nos dias subseqüentes o processo de reparação, medido pela variável grau de reparação, evoluiu de forma linear, de modo que, no 12º dia, a área reparada alcançou 77,95 por cento da região ulcerada inicial no grupo Controle, 78,40 por cento no grupo Referência e 83,49 por cento no grupo Teste, não sendo constatadas diferenças estatisticamente significante. Igualmente semelhantes foram os valores da taxa média de reparação referente aos 12 dias de tratamento: 25,79 mm²/dia no grupo Controle, 25,42 mm²/dia no grupo Referência e 27,38 mm²/dia no grupo Teste CONCLUSÃO: O composto em Teste, aplicado por via tópica em úlceras cutâneas experimentalmente induzidas em ratos, não acelerou o processo de reparação recidual por segunda intenção.

Animals , Male , Rats , Linoleic Acid/therapeutic use , Skin Ulcer/drug therapy , Soybean Proteins/therapeutic use , Triglycerides/therapeutic use , Vitamins/therapeutic use , Wound Healing/drug effects , Disease Models, Animal , Drug Combinations , Drug Evaluation, Preclinical , Rats, Wistar , Time Factors , Vitamin A/therapeutic use , Vitamin E/therapeutic use
Rev. Inst. Med. Trop. Säo Paulo ; 50(1): 51-52, Jan.-Feb. 2008.
Article in English | LILACS (Americas) | ID: lil-476764


We report here a rare case of cutaneous infection due to Corynebacterium pseudodiphtheriticum. The patient presented to the clinical laboratory with a skin ulcer on his left leg. Gram-stained preparation of the purulent secretion revealed the presence of numerous rod-shaped Gram-positive organisms in the absence of any other species. The organism was grown in pure culture on sheep blood agar and was further identified as C. pseudodiphtheriticum using a commercial identification system (API-Coryne, BioMérieux, France). The infection was successfully treated with ciprofloxacin. This case emphasizes the importance of the clinical microbiology laboratory in correctly identifying Gram-positive organisms obtained in pure culture from skin ulcers.

Reportamos o isolamento de Corynebacterium pseudodiphtheriticum de um caso de infecção cutânea. O paciente apresentou-se ao laboratório clínico com uma úlcera na perna esquerda. A coloração de Gram do material revelou a presença de bacilos Gram-positivos e ausência de outras espécies bacterianas. O organismo foi isolado em cultura pura no ágar sangue de carneiro e foi identificado como C. pseudodiphtheriticum através de um sistema de identificação comercial (API-Coryne, BioMérieux, França). A infecção foi tratada com sucesso através do uso de ciprofloxacina. Este caso reforça a importância do laboratório de microbiologia clínica na identificação de organismos Gram-positivos isolados de cultura pura de amostras de úlceras cutâneas.

Humans , Male , Corynebacterium Infections/microbiology , Corynebacterium/isolation & purification , Skin Diseases, Bacterial/microbiology , Skin Ulcer/microbiology , Anti-Infective Agents/therapeutic use , Ciprofloxacin/therapeutic use , Corynebacterium/classification , Immunocompromised Host , Skin Diseases, Bacterial/diagnosis , Skin Diseases, Bacterial/drug therapy , Skin Ulcer/diagnosis , Skin Ulcer/drug therapy
Yonsei Medical Journal ; : 573-585, 2007.
Article in English | WPRIM (Western Pacific) | ID: wprim-96541


Behcet's disease is particularly prevalent in "Silk Route" populations, but it has a global distribution. The diagnosis of the disease is based on clinical criteria as there is as yet no pathognomonic test, and mucocutaneous lesions, which figure prominently in the presentation and diagnosis, may be considered the diagnostic hallmarks. Among the internationally accepted criteria, painful oral and genital ulcers, cutaneous vasculitic lesions and reactivity of the skin to needle prick or injection (the pathergy reaction) are considered hallmarks of Behcet's disease, and often precede other manifestations. Their recognition may permit earlier diagnosis and treatment, with salutary results. This paper describes the various lesions that constitute the syndrome and focuses on those that may be considered characteristic.

Behcet Syndrome/drug therapy , Female , Humans , Male , Oral Ulcer/drug therapy , Skin Ulcer/drug therapy , Thrombophlebitis/drug therapy
Acta méd. costarric ; 48(3): 135-138, jul.-set. 2006. ilus
Article in Spanish | LILACS (Americas) | ID: lil-581186


Se discute el caso de un paciente con infección por el virus de inmunodeficiencia humana VIH avanzado que se presenta con una úlcera crónica de la rodilla derecha, a quien se le realizaron múltiples estudios de laboratorio y de gabinete, sin lograr aislarse ningún germen específico, sin embargo, un estudio histológico demostró la presencia de bacilos alcohol ácido resistentes. Se manejó médicamente con buena respuesta clínica al tratamiento.

A case of a patient with HIV infection and a chronic ulcer in the right knee is discussed. Several studies were done but none helped identifying the cause of the ulcer. However, histological examination of the ulcer showed acid alcohol resistant bacilli. The patient received medical treatment and had a good response.

Humans , Male , Adult , Acquired Immunodeficiency Syndrome , Knee Injuries , Skin Ulcer/drug therapy , Skin Ulcer/therapy
Rev. chil. dermatol ; 21(3): 198-199, 2005. ilus
Article in Spanish | LILACS (Americas) | ID: lil-455687


La sarcoidosis es una enfermedad granulomatosa crónica multisistémica de origen desconocido, caracterizada histológicamente por granulomas no caseosos. Los órganos más afectados son: pulmón, ojo, hueso y piel. La afectación cutánea ocurre en, aproximadamente, un 25 por ciento de los casos. Una presentación infrecuente es la sarcoidosis ulcerativa, encontrando en la bibliografía sólo 39 casos descritos previamente. La sarcoidosis ulcerativa afecta más frecuentemente a mujeres negras, jóvenes-adultas; la localización típica son las extremidades inferiores y el tratamiento de elección son los corticosteroides. Presentamos el caso de una mujer de 32 años, que sobre cicatrices desarrolló lesiones ulceradas. La biopsia demostró granulomas no caseosos. La respuesta al tratamiento con corticoides orales fue exitosa.

Adult , Humans , Female , African Continental Ancestry Group , Sarcoidosis/complications , Sarcoidosis/diagnosis , Skin Ulcer/etiology , Skin Ulcer/drug therapy , Age Factors , Skin Diseases/etiology , Prednisone/therapeutic use , Risk Factors
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2005; 15 (3): 187-8
in English | IMEMR (Eastern Mediterranean) | ID: emr-71523


Embolia cutis medicamentosa or Nicolau syndrome is an acute necrotic condition of skin and subcutis that follows intramuscular administration of certain medicines. A young lady from rural area presented with an irregular-contoured ulceration with livedoid features on left deltoid region which she developed after receiving intramuscular injection of diclofenac sodium. The histopathological examination of the biopsied tissue demonstrated dead keratinocytes with degenerated epidermis and dermis. The condition improved on local management of wound with a residual scar

Humans , Female , Skin Ulcer/pathology , Skin Ulcer/drug therapy , Administration, Topical , Drug Hypersensitivity/diagnosis , Diclofenac/adverse effects , Necrosis , Risk Assessment , Anti-Bacterial Agents