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1.
Arq. bras. neurocir ; 39(3): 222-227, 15/09/2020.
Article in English | LILACS | ID: biblio-1362426

ABSTRACT

Introduction Angiosarcoma (AG) is a malignant mesenchymal neoplasm that predominantly affects the soft tissues and, to variable degrees, expresses themorphological and functional characteristics of the endothelium. The incidence of sarcomas of the central nervous system(CNS) is low (0.5% to 2.7%), and AGs involving the brain are even rarer. Case Description A 45-year-old male patient presented with complaints of headache, nausea, and vomiting. An examination showed bilateral papilledema and a right lung pleurotomy. The patient's previous history included drug addiction, pulmonary tuberculosis, lung abscess, pleural empyema, and pulmonary artery embolization for severe hemoptysis. Computed tomography/magnetic resonance imaging scans revealed a large intra-axial lesion extending into the right parietal and temporal lobes, with hemorrhagic zones. The patient underwent surgical resection of the lesion. Microscopy showed a poorly-differentiated, high-grade malignant tumor composed of plump/epithelioid cells forming small vascular spaces and solid nests, compatible with AG.In the postoperative period, the patient developed recurrent hemoptysis. A biopsy of the tissues adjacent to the pleurotomy determined the diagnosis of pulmonary AG. At 30 days after the resection, the patient died from hemoptysis, hemothorax, lung atelectasis, and intracranial hypertension related to the recurrence of the brain tumor. Conclusion Angiosarcoma is a rare neoplasia related to short survival due to the high proliferative index, which must be considered in patients presenting hemorrhagic tumors. No specific genetic abnormalities have been described for this neoplasia.


Subject(s)
Humans , Male , Middle Aged , Tuberculosis, Pulmonary/etiology , Anemia , Hemangiosarcoma/surgery , Hemangiosarcoma/complications , Prognosis , Soft Tissue Neoplasms/diagnosis , Central Nervous System Neoplasms/diagnosis , Hemangiosarcoma/physiopathology , Hemangiosarcoma/diagnostic imaging , Neoplasm Metastasis
2.
Rev. medica electron ; 41(2): 530-536, mar.-abr. 2019. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1004285

ABSTRACT

RESUMEN El dermatofibrosarcoma protuberante es un raro tumor fibrohistiocitario de la piel y grado intermedio de malignidad. Localmente tiene un comportamiento agresivo, se extiende al tejido celular subcutáneo y músculo subyacente. Su crecimiento es lento e indoloro con una alta frecuencia de recurrencia posterior a la intervención quirúrgica. Se presentó una paciente operada en el Servicio de Cirugía General del "Hospital Universitario Dr. Mario Muñoz Monroy" de Colón, Matanzas. Diagnosticada con dermatofibrosarcoma protuberans se presentó con un tumor de partes blandas, localizado en parrilla costal izquierdo, recidivante sobre una lesión resecada anteriormente hacia 8 meses. El tumor de superficie multinodular e irregular, de aproximadamente 3 a 4 cm de diámetro, presentaba zonas de color azuladas y otras más oscuras con un área enrojecida circundante, consistencia dura, y no adherida a planos profundos. Con el resultado anatomopatológico se ratificó el diagnóstico. Nuevamente se aplicó tratamiento quirúrgico con amplios márgenes libres de tumor. Las metástasis son raras y pocos frecuentes, pero localmente pueden infiltrar, grasa, fascia, músculos y hasta estructuras óseas. Cuando se presentan ocurren generalmente en pulmón y ganglios linfáticos regionales, en estos casos la supervivencia es muy poca.


ABSTRACT Dermatofibrosarcoma protuberant (DFSP) is a rare fibrohistiocytic skin tumor of intermediate level of malignance. Locally it has an aggressive behavior extending to the subcutaneous cellular tissue and underlying muscle. Its grow is slow and painless with a high recurrence frequency after surgery. The authors present the case of a female patient operated in the Service of General Surgery of the University Hospital ¨Dr. Mario Muñoz Monroy¨ of Colon, Matanzas. Diagnosed with dermatofibrosarcoma protuberant, she arrived to the consultation with a tumor of soft tissues located in left rib cage, recidivist on a lesion resected 8 months before. It had a multinodular and irregular surface, of around 3-4 cm diameter, with bluish and dark blue areas and a reddened surrounding area of hard consistence, not adhered to deep planes. The diagnosis was ratified by the neuropathologic result. The surgical treatment was applied again with wide free-tumors margins. Metastases are rare and few frequent, but locally they can infiltrate fat, fascia, muscles and even bone structures. When they present they occur mainly in lung and regional lymphatic ganglia; in these cases survival is scarce.


Subject(s)
Humans , Female , Adult , Dermatofibrosarcoma/surgery , Dermatofibrosarcoma/pathology , Dermatofibrosarcoma/diagnostic imaging , Skin Neoplasms/diagnosis , Soft Tissue Neoplasms/diagnosis , Neoplasm Recurrence, Local
3.
Acta ortop. mex ; 33(2): 81-87, mar.-abr. 2019. tab
Article in Spanish | LILACS | ID: biblio-1248639

ABSTRACT

Resumen: Introducción: Los tumores en la mano son poco frecuentes y los tumores malignos son particularmente raros; sin embargo, las lesiones seudotumorales primarias de la mano, como gangliones, son muy frecuentes. La mayoría de los tumores que se encontraron en el hueso y tejido blando pueden presentarse de igual manera en la mano, pero su frecuencia y distribución es distinta. A pesar de la baja incidencia de los tumores benignos y malignos en la mano, éstos pueden ser localmente invasivos o comprometer su función. El objetivo principal de este estudio es determinar la epidemiología, tipos, localización y manejo de los tumores y seudotumores de la mano en adultos en población mexicana. Material y métodos: Se diseñó un estudio retrospectivo mediante revisión de expedientes clínicos de pacientes de nuestra institución con diagnóstico de tumores o seudotumores en la mano de Enero de 2007 a Diciembre de 2016 evaluando variables como edad, género, lateralidad, abordaje diagnóstico, estirpe histológica, localización y tratamiento. Resultados: Nuestro estudio comprende 215 pacientes con una edad promedio de 44.23 años, predominantemente mujeres. Los seudotumores son los que con más frecuencia se detectan (quiste sinovial), seguidos de los tumores benignos de tejido blando, tumores óseos benignos y, por último, los tumores malignos. Discusión: Después de todo, sólo sugerimos una clasificación para la mano que es sencilla y reproducible y dar orientación para el tratamiento. La necesidad de un sistema de clasificación es inminente para estandarizar los diagnósticos, guiar futuras investigaciones, enfocar tratamientos y preservar la función de la mano, independientemente de la epidemiología que se observe.


Abstract: Introduction: Tumors in the hand are rare, and malignant tumors in the hand are peculiar; However, primary pseudotumoral lesions of the hand, such as ganglion, are very frequent. Most of the tumors found in the bone and soft tissue can be presented in the same way in the hand but their frequency and distribution is different. Despite the low incidence of benign and malignant tumors in the hand, these can be locally invasive or compromise the hand function. The main objective of this study is to determine the epidemiology, types, location and management of tumors and pseudotumors of the hand in adults in the Mexican population. Material and methods: We designed a retrospective study by review of clinical records of patients in our institution with diagnosis of tumors or pseudotumors in hand from January 2007 to December 2016 evaluating variables such as age, gender, laterality, Diagnosis, histological lineage, localization and treatment. Results: Our study comprises 215 patients with an average age of 44.23 years, predominantly women. Pseudotumors are the most frequently encountered (synovial cyst), followed by benign soft tissue tumors, benign bone tumors, and, finally, malignant tumors. Discussion: After all we suggests a possible new classification for the hand that is simple, reproducible and give guidance for treatment. The need for a classification system is imminent to standardize diagnostics, guide future research, focus treatments and preserve hand function.


Subject(s)
Humans , Male , Female , Adult , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/epidemiology , Bone Neoplasms/diagnosis , Bone Neoplasms/epidemiology , Hand/pathology , Incidence , Retrospective Studies
4.
Rev. chil. pediatr ; 89(5): 655-659, oct. 2018. graf
Article in Spanish | LILACS | ID: biblio-978139

ABSTRACT

Resumen: Introducción: el hamartoma fibroso de la infancia (HFI) es un tumor benigno de partes blandas que se presenta generalmente en población infantil y que posee una morfología histológica característica. Objetivo: describir un caso de HFI congénito de características clínicas e histológicas atípicas. Caso Clínico: recién nacido de término, sexo masculino, sin antecedentes mórbidos perinatales, es deriva do a dermatología por placa eritematosa congénita en región umbilical. Estudio histológico evidenció proliferación fusocelular en dermis e hipodermis, de morfología bifásica, con un patrón arremolina do infiltrante y otro de bandas de células fusadas con hábitos fibroblásticos y miofibroblásticos, aso ciada en profundidad a un componente de tejido adiposo maduro. El estudio inmunohistoquímico mostró positividad difusa a CD34 y focalmente para FXIIIa, con ausencia de inmunoreactividad a ac- tina, desmina, MyoD1, S100, HMB45, Melan A y EMA. Fluorescent in situ hybridization (FISH) para platelet-derived growth factor beta (PDGF beta) y para el gen ETV6 negativos, presentes en el dermatofibrosarcoma protuberans congénito y fibrosarcoma infantil, respectivamente. Estos antecedentes, sumado a los hallazgos histológicos previos, apoyaron el diagnóstico de HFI. Se realizó extirpación quirúrgica, sin signos de recidiva durante el seguimiento clínico. Conclusión: es importante consi derar el HFI dentro del diagnóstico diferencial de tumores subcutáneos infantiles, principalmente en población menor de 2 años. Si bien su comportamiento es benigno, presenta similitud con múltiples lesiones benignas y malignas, lo que hace imperativo realizar un estudio histológico exhaustivo ante lesiones clínicas sospechosas.


Abstract: Introduction: Fibrous hamartoma of infancy (FHI) is a benign, soft tissue tumor that usually oc curs in children and has a characteristic histological morphology. Objective: To describe a case of congenital FHI with atypical histological and clinical characteristics. Clinical case: Full-term male newborn, with no perinatal morbid history was referred to dermatology due to a congenital erythe matous plaque in the umbilical region. The histological study showed a fusocelullar proliferation in dermis and hypodermis of biphasic distribution, with an infiltrative, swirling pattern and bundles of spindle fibroblast-like and myofibroblast-like cells, associated in depth with a mature adipose tissue component. The immunohistochemical study revealed diffuse positivity for CD34, and focal posi tivity for FXIIIa, without immunoreactivity for actin, desmin, MyoD1, S100, HMB45, Melan-A, or EMA. Fluorescent in situ hybridization (FISH) was negative for platelet-derived growth factor recep tor beta (PDGFR-beta) and for ETV6 gene. PDGFR-beta and ETV6 gene are present in congenital dermatofibrosarcoma protuberans and infantile fibrosarcoma, respectively. This history, in addition to previous histological findings, supported the diagnosis of FHI. Surgical resection was performed, without signs of recurrence during clinical follow-up. Conclusion: It is important to consider the FHI within the differential diagnosis of subcutaneous tumors in children, especially in those under two years of age. Although its behavior is benign, it is similar to multiple benign and malignant le sions, which makes it imperative to perform a histological study in front of suspicious clinical lesions.


Subject(s)
Humans , Male , Infant, Newborn , Soft Tissue Neoplasms/diagnosis , Umbilicus/pathology , Hamartoma/diagnosis , Soft Tissue Neoplasms/congenital , Soft Tissue Neoplasms/pathology , Hamartoma/congenital , Hamartoma/pathology
6.
Rev. cuba. cir ; 57(1): 72-77, ene.-mar. 2018. ilus
Article in Spanish | LILACS | ID: biblio-960349

ABSTRACT

Los defectos de pared abdominal son un desafío para los cirujanos plásticos. El sarcoma de partes blandas es muy recidivante y hay que hacer amplias exéresis con margen oncológico y como consecuencia quedan amplias zonas por reconstruir. El colgajo transverso de recto abdominal es una opción reconstructiva de esta región con buenos resultados estéticos y funcionales. El objetivo del trabajo es mostrar los resultados de la reconstrucción inmediata de la pared abdominal luego de una amplia exéresis oncológica. Se presenta una paciente femenina, mestiza, de 60 años, con diagnóstico de sarcoma de partes blandas, que abarcaba todo el hemiabdomen ínfero izquierdo hasta límites del reborde costal izquierdo, comprometía aponeurosis, el músculo recto izquierdo, y pequeña parte del peritoneo que se reparó. Se decidió una amplia exéresis y se planificó la reconstrucción con un colgajo miocutáneo transverso de recto del abdomen. Se utilizaron mallas de polipropileno. Se logró la reconstrucción inmediata del defecto oncológico con buenos resultados estéticos y funcionales(AU)


Abdominal wall defects are a challenge for plastic surgeons. Soft-tissue sarcoma is very recurrent and it is necessary to make extensive exeresis with oncological margin and, as a result, there are large areas to be reconstructed. The transverse rectus abdominis flap is a reconstructive option for this region and with good aesthetic and functional results. The objective of the work is to show the results of the immediate reconstruction of the abdominal wall after an extensive oncological exeresis. We present the case of a female patient, mestiza, aged 60 years, with a diagnosis of soft-tissue sarcoma, which encompassed all the left inferior hemiabdomen to the left costal margin limits, compromised the aponeurosis, the left rectus muscle, and a small part of the peritoneum that was repaired. A wide exeresis was decided and the reconstruction was planned with a transverse rectus abdominis myocutaneous flap. Polypropylene meshes were used. The immediate reconstruction of the oncological defect was achieved with good aesthetic and functional results(AU)


Subject(s)
Humans , Female , Middle Aged , Soft Tissue Neoplasms/diagnosis , Surgical Mesh/statistics & numerical data , Abdominal Wall/surgery , Myocutaneous Flap/adverse effects
7.
An. bras. dermatol ; 92(4): 546-549, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-886990

ABSTRACT

Abstract: Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.


Subject(s)
Humans , Male , Adult , Soft Tissue Neoplasms/pathology , Lipoma/pathology , Liposarcoma/pathology , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/diagnosis , Biopsy , Buttocks/pathology , Diagnosis, Differential , Lipoma/surgery , Lipoma/diagnosis , Liposarcoma/surgery , Liposarcoma/diagnosis
8.
Gac. méd. espirit ; 17(3): 234-248, dic. 2015.
Article in Spanish | LILACS | ID: lil-769355

ABSTRACT

Fundamento: Los tumores que se originan en la región sacrococcígea son raros, representan del uno al siete por ciento de los tumores espinales primarios. Sin embargo, su diagnóstico y tratamiento imponen un reto para el equipo quirúrgico, por la complejidad de las relaciones anatómicas y las características biológicas de las lesiones más frecuentes. Objetivo: Actualizar y sistematizar los conocimientos sobre las generalidades de los tumores de la región sacrococcígea. Desarrollo: Son más frecuentes en adultos jóvenes del sexo masculino, debutan con dolor inespecífico en la espalda baja, a lo que se suman progresivamente la debilidad muscular, el déficit sensitivo y los trastornos esfinterianos. Pueden ser epidurales o intradurales, primarios o secundarios, neoplásicos o no y originarse en las partes blandas o en las estructuras óseas. La edad y la localización deben ser consideradas para evaluar el potencial de malignidad. La tomografía axial computarizada y la resonancia magnética nuclear son los estudios confirmatorios y permiten la selección del abordaje quirúrgico. Las lesiones que con más frecuencia se reportan son el cordoma, el quiste óseo aneurismático y el tumor de células gigantes. La radioterapia y la quimioterapia pueden complementar la cirugía en dependencia de la histología. Conclusiones: El diagnóstico precoz necesita la sospecha ante síntomas inespecíficos. El tratamiento de los tumores de la región sacrococcígea debe ser multidisciplinario y multimodal, para garantizar un mejor pronóstico y mayor supervivencia de los pacientes.


Background: tumors arising from sacrococcygeal region are weird and represent from one to seven percent of primary spinal tumors. However diagnosis and treatment are a challenge for the surgical staff because of the anatomic relations complexity and the more frequent lesions biological features. Objective: a review of the literature was done to update and systematize the knowledge about general aspects of sacrococcygeal tumors. Development: they are more frequent in male young adults, unspecific low back pain is the onset symptom and muscle weakness, sense deficit and sphincter disturbances join up later progressively. They can be epidural or intradural, primary or secondary, neoplastics or not and they could arise from soft tissues or bone structure. Age and location most be considered to evaluate malignant potential. CT scan and magnetic resonance imaging are the confirmatory tests and allow surgical approach selection. The most frequent affections are chordoma, aneurismal bone cyst and giant cell tumor. Radiotherapy and chemotherapy can support surgery according to histology. Conclusions: precocious diagnosis needs to be suspected before unspecific symptoms. Sacrococcygeal tumors treatment most be multidisciplinary and multimodal to assure better prognosis and patient´s life expectancy increasing.


Subject(s)
Humans , Sacrococcygeal Region/surgery , Soft Tissue Neoplasms/diagnosis , Early Detection of Cancer , Tomography, Spiral Computed
9.
Rev. otorrinolaringol. cir. cabeza cuello ; 75(3): 261-264, dic. 2015. ilus
Article in Spanish | LILACS | ID: lil-771699

ABSTRACT

En el siguiente artículo se presenta un caso clínico de un adolescente de 14 años que consulta por presentar un aumento de volumen supraclavicular derecho y cuyo diagnóstico final realizado mediante estudio histológico luego de exéresis de la masa, concluye ser un hibernoma. Considerando la infrecuencia con la que se presentan este tipo de tumores benignos de los tejidos blandos, presentamos una descripción, mediante revisión bibliográfica, de dicha patología.


In this article, we present a clinical case of a 14 years old teen who presented a su-pracavicular growing mass and whose diagnosis made by histologic examination after performing excision, proves to be a hibernoma. Given the infrequency with wich these types of benign tumors of the soft tissues occur, we present a description, based on a literature review of such pathology.


Subject(s)
Humans , Male , Adolescent , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/surgery , Lipoma/diagnosis , Lipoma/surgery , Biopsy , Clavicle/surgery , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/surgery , Tomography, X-Ray Computed
10.
Article in French | AIM | ID: biblio-1260264

ABSTRACT

Les tumeurs des tissus mous (TTM) sont un ensemble heteroclite; rare et de diagnostic histopathologique parfois difficile. L'immunohistochimie constitue un moyen complementaire d'un apport decisif. Nous rapportons ici une serie de 36 TTM; dont le diagnostic comparatif a ete fait entre Dakar et Bordeaux avec parfois utilisation de l'immunohistochimie (IHC) dans cette derniere ville pour la confirmation du diagnostic definitif. L'IHC a permis de redresser le type histologique dans 100 % des tumeurs benignes (2/2) et dans 60 % des tumeurs malignes (6/10). Bien etant une aide incontournable; l'IHC ne peut ni remplacer ni preceder un examen histologique standard qui represente la cle du diagnostic a condition que le pathologiste soit experimente


Subject(s)
Immunohistochemistry , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/physiopathology
11.
Article in English | WPRIM | ID: wpr-69212

ABSTRACT

BACKGROUND: We aimed to describe the clinical characteristics and outcomes of unplanned excisions of synovial sarcomas. METHODS: In total, 90 patients with synovial sarcomas in the extremities were retrospectively reviewed. Patients were divided into unplanned excision (n = 38) and planned excision (n = 52) groups. The average follow-up period was 6 years. The clinicopathological characteristics and oncologic outcomes were compared. RESULTS: The unplanned excision group showed longer duration of symptoms before diagnosis (p = 0.023), smaller lesion dimensions (p = 0.001), superficial location (p = 0.049), and predilection in the upper extremities (p = 0.037). Synovial sarcomas were most commonly misdiagnosed as neurogenic tumors (56%) in the upper extremities or as cystic masses (47%) in the lower extremities. Oncological outcomes, including disease-specific survival, metastasis-free survival, or local recurrence were not significantly different between the 2 groups (p = 0.159, p = 0.444, and p = 0.335, respectively). Repeated unplanned excision (p = 0.012) and delayed re-excision (p = 0.038) were significant risk factors for local recurrence in the unplanned excision group. CONCLUSIONS: Synovial sarcomas treated with unplanned excision had distinct characteristics. These findings are important for developing diagnostic and therapeutic strategies for synovial sarcoma.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Retrospective Studies , Sarcoma, Synovial/diagnosis , Soft Tissue Neoplasms/diagnosis , Treatment Outcome , Young Adult
13.
Rev. chil. dermatol ; 30(2): 138-150, 2014. ilus
Article in Spanish | LILACS | ID: biblio-835935

ABSTRACT

Los hemangiomas de la infancia (HI) son los tumores de partes blandas más frecuentes de la infancia. Se presentan en un 5 por ciento- 10 por ciento de la población pediátrica. El comportamiento de estos tumores es especial, ya que, a diferencia de otras neoplasias benignas, los HI tienden a regresar e involucionar espontáneamente en un 90 por ciento. Algunos pacientes con HI pueden sufrir complicaciones tales como ulceración y hemorragia. Estas complicaciones han llevado a la búsqueda de alternativas terapéuticas, donde, por mucho tiempo fueron los esteroides la primera opción de tratamiento. Esto hasta el año 2008, cuando se descubre accidentalmente el propranolol administrado por vía oral, como alternativa terapéutica para los HI severos, convirtiéndose hasta el día de hoy, en el gold standard de tratamiento. Dado la diversidad en su presentación, y las diferentes alternativas de manejo existentes, es que esta revisión pretende abordar la patogenia, clínica y enfrentamiento de estos tumores de la infancia.


Hemangiomas of infancy (HI) are the most common soft tissue tumors of childhood. They occur in up to percent-10 percent of the pediatric population and they have a special behaviour because, unlike other benign neoplasms, HI tend to regress spontaneously in up to 90 percent of the cases. Complications such as ulceration and hemorrhage can occur. These complications have led to search for new therapeutic options. Steroids were the first choice of treatment for a long time, until 2008, when oral propranolol was accidentally discovered as a potential treatment for large HI4. Today, propranolol is the gold standard for treatment. Given their variable clinical presentation and different therapeutic options available nowadays, this paper to review the pathogenesis, clinical presentation and approach of these tumors of infancy.


Subject(s)
Humans , Child , Hemangioma/diagnosis , Hemangioma/therapy , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/therapy , Diagnosis, Differential , Hemangioma/classification , Hemangioma/complications , Hemangioma/etiology , Soft Tissue Neoplasms/classification , Soft Tissue Neoplasms/complications , Soft Tissue Neoplasms/etiology
14.
Dermatol. argent ; 20(2): 113-118, 2014.
Article in Spanish | LILACS | ID: lil-784789

ABSTRACT

El sarcoma epitelioide es una neoplasia maligna de partes blandas, infrecuente.Suele ser diagnosticada en forma tardía, debido a que su presentación clínica ymorfológica es similar a la de otras afecciones. Presenta un alto índice de recurrencia local y de metástasis, principalmente en ganglios y pulmón.Se comunican dos pacientes jóvenes de sexo femenino con sarcoma epitelioide,una con la variante distal, con afectación de mano izquierda y la otra, embarazada,con la variante proximal en región inguinovulvar...


Subject(s)
Humans , Female , Young Adult , Soft Tissue Neoplasms/diagnosis , Sarcoma , Anatomy , Groin , Hand , Neoplastic Processes
15.
Article in English | WPRIM | ID: wpr-184383

ABSTRACT

Calcifying aponeurotic fibroma is a rare, benign fibroblastic tumor. The lesion has a propensity for local invasion and a high recurrent rate. Therefore, accurate preoperative diagnosis and complete excision are important to prevent the recurrence of the tumor after surgical removal. However, radiographic and magnetic resonance imaging findings of calcifying aponeurotic fibroma have been extremely rarely described in the radiology literature. Thus, we report a rare case of calcifying aponeurotic fibroma affecting the dorsal wrist in a 67-year-old man, describe radiographic and MR findings, and discuss the differential diagnosis of the tumor.


Subject(s)
Aged , Calcinosis/diagnosis , Diagnosis, Differential , Fibroma/diagnosis , Humans , Magnetic Resonance Imaging/methods , Male , Neoplasm Recurrence, Local/diagnosis , Soft Tissue Neoplasms/diagnosis , Wrist/pathology
16.
Article in Korean | WPRIM | ID: wpr-56667

ABSTRACT

Low-grade fibromyxoid sarcoma is a slowly growing soft tissue neoplasm that shows benign histologic features but may have clinical course of malignant disease. It has been reported to occur in the thigh, inguinal area, axilla, shoulder, neck, perineum or buttock. However, there have been few cases of abdominal organ involvement. A 21-year-old woman presented with a large palpable abdominal mass. A 7x4 cm sized round soft tissue tumor at right upper quadrant area was identified by abdominopelvic CT scan. Percutaneous ultrasound-guided biopsy revealed features of spindle cell tumor. On exploration, the tumor originated from transvers colon and was attached to gastrocolic ligament, transverse mesocolon and stomach. The tumor could be dissected with transverse colectomy and partial gastrectomy. The excised tumor, measuring 7x5x5 cm, was well demarcated and appeared as an ovoid mass with firm and myxoid cut surface. She was diagnosed with low-grade fibromyxoid sarcoma arising from transverse colon, and is currently being followed-up without recurrence or metastasis.


Subject(s)
Colon, Transverse , Female , Humans , S100 Proteins/metabolism , Sarcoma/diagnosis , Soft Tissue Neoplasms/diagnosis , Stomach Neoplasms/pathology , Tomography, X-Ray Computed , Young Adult
17.
Article in English | WPRIM | ID: wpr-18388

ABSTRACT

BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that usually affects young patients. Because of the rarity of the disease, most reports relating to ASPS are in the form of case reports or small series. METHODS: We performed a retrospective study to evaluate the clinicopathologic features, treatment, outcome and pattern of treatment failure in a consecutive series of patients with localized or metastatic ASPS between 1996 and 2011. Demographics, tumor sizes, sites and extent of disease, treatments provided, progression-free survival, and overall survival were evaluated. RESULTS: A total of 19 patients were identified. The clinical assumptive diagnosis of the first medical examination doctor was benign soft tissue tumor in 5 cases (26%) and benign hemangioma in 4 cases (21%), delaying treatment. The most common location of primary tumor was the thigh. The median diameter of the mass was 55 mm (range, 10 to 130 mm). An R0 resection was obtained in 11 cases. Adjuvant radiotherapy was delivered in 8 cases; postoperative systemic chemotherapy was delivered in 10 cases. Eight out of 15 patients (53%) exhibited metastases either at presentation or later. Median overall follow-up was 54 months. CONCLUSIONS: The treatment principle for alveolar soft tissue sarcoma is massive resection, and when the surgical margin is questionable, radiation treatment can be added for prevention of local recurrence. Also, due to discovery of metastases and local recurrence, even after 5 years of general treatment, outpatient department follow-up is needed, and we need to keep in mind that lung, intracranial, and bone metastases are common.


Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Retrospective Studies , Sarcoma, Alveolar Soft Part/diagnosis , Soft Tissue Neoplasms/diagnosis , Young Adult
18.
Indian J Cancer ; 2013 July-Sept; 50(3): 164-169
Article in English | IMSEAR | ID: sea-148643

ABSTRACT

BACKGROUND: Liposarcomas are among the most common soft tissue sarcomas in adulthood. AIM: The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions. MATERIALS AND METHODS: The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2. STATISTICAL ANALYSIS USED: Chi-Square test was applied. RESULTS: 20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01). CONCLUSION: p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.


Subject(s)
Female , Humans , Immunohistochemistry , Liposarcoma/classification , Liposarcoma/diagnosis , Liposarcoma/metabolism , Male , Proto-Oncogene Proteins c-mdm2/analysis , Proto-Oncogene Proteins c-mdm2/biosynthesis , Soft Tissue Neoplasms/classification , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/metabolism , Biomarkers, Tumor/analysis , Tumor Suppressor Protein p53/biosynthesis , World Health Organization
19.
West Indian med. j ; 62(6): 554-556, July 2013. ilus
Article in English | LILACS | ID: biblio-1045697

ABSTRACT

Hibernomas are uncommon benign tumours that arise from the remnants of fetal brown adipose tissue. They are usually asymptomatic and have a slow growth pattern. Intrathoracic and pleural locations are exceptional for localization of hibernoma. A review of the English language medical literature revealed more than 110 cases, 20 of which were intrathoracic. In the article below, we discuss a 40-year old male patient who had pleural involvement and was treated by surgical resection. Following resection, the patient has remained problem-free for nine years.


Los hibernomas son tumores benignos poco frecuentes que surgen de restos del tejido adiposo marrón fetal. Son generalmente asintomáticos y tienen un patrón de crecimiento lento. Las localizaciones intratorácicas y pleurales son excepcionales para la localización del hibernoma. Una revisión de la literatura médica en lengua inglesa reveló más de 110 casos, 20 de los cuales se trataban de hibernomas intratorácicos. En el siguiente artículo, discutimos el caso de un paciente de 40 años de edad, que tenía una afección pleural y fue tratado con una resección quirúrgica. Después de la resección, el paciente ha permanecido sin problemas durante nueve años.


Subject(s)
Humans , Adult , Soft Tissue Neoplasms/diagnosis , Thoracic Neoplasms/diagnosis , Lipoma/diagnosis , Thoracotomy , Tomography, X-Ray Computed
20.
Bahrain Medical Bulletin. 2013; 35 (4): 221-223
in English | IMEMR | ID: emr-143113

ABSTRACT

A fifty-three-year-old Bahraini male presented with a painless, slow growing mass in the left gluteal region. A work-up including pelvic MRI, chest CT scan and excisional biopsy was performed. The histology was low-grade fibromyxoid sarcoma [LGFMS]. Immunohistochemistry tests confirmed the diagnosis. He received local radiotherapy as an alternative for re-resection. Changes in the liver were suspicious but an ultrasound and MRI of the liver ruled out liver metastases. The patient is maintained under close observation because the tumor has high tendency of local recurrence and possible pulmonary and liver metastases. This specific distinctive entity of soft tissue sarcoma is yet to be reported in Bahrain; it has no clear protocol regarding the best follow-up recommendations.


Subject(s)
Humans , Male , Fibrosarcoma/diagnosis , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/pathology , Histocytochemistry , Rare Diseases , Neoplasm Metastasis , Health Planning Guidelines
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