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Chinese Journal of Pathology ; (12): 19-24, 2023.
Article in Chinese | WPRIM | ID: wpr-970119


Objective: To investigate the clinicopathological features, immunophenotypes and molecular genetics of EWSR1-SMAD3 positive fibroblastic tumor (ESFT) with an emphasis on differential diagnosis. Methods: The clinicopathological data, immunohistochemical profiles and molecular profiles of 3 ESFT cases diagnosed at the Department of Pathology, Fudan University Shanghai Cancer Center from 2018 to 2021were analyzed. The related literature was also reviewed. Results: There were two males and one female. The patients were 24, 12 and 36 years old, respectively. All three tumors occurred in the subcutis of the foot with the disease duration of 6 months to 2 years. The tumors were presented with a slowly growing mass or nodule, accompanied with pain in 1 patient. The tumors ranged in size from 0.1 to 1.6 cm (mean, 1.0 cm). Microscopically, the tumors were located in the subcutaneous tissue with a nodular or plexiform growth pattern. They were composed of cellular fascicles of bland spindle cells with elongated nuclei and fine chromatin. One of the tumors infiltrated into adjacent adipose tissue. There was no nuclear atypia or mitotic activities. All three tumors showed prominent stromal hyalinization with zonal pattern present in one case. Focal punctate calcification was noted in two cases. The immunohistochemical studies showed that tumor cells were diffusely positive for ERG and negative for CD31 and CD34, with Ki-67 index less than 2%. Fluorescence in situ hybridization on the two tested cases identified EWSR1 gene rearrangement. The next generation sequencing analysis demonstrated EWSR1-SMAD3 fusion in all three cases. During the follow up, one patient developed local recurrence 24 months after the surgery. Conclusions: ESFT is a benign fibroblastic neoplasm and has a predilection for the foot, characterized by ERG immunoreactivity and EWSR1-SMAD3 fusion. Local recurrence might occur when incompletely excised. Familiarity with its clinicopathological features is helpful in distinguishing it from other spindle cell neoplasms that tend to occur at acral sites.

Adult , Child , Female , Humans , Male , Biomarkers, Tumor/analysis , China , In Situ Hybridization, Fluorescence , Neoplasms, Fibrous Tissue/pathology , RNA-Binding Protein EWS/genetics , Smad3 Protein/genetics , Soft Tissue Neoplasms/surgery
Rev. chil. ortop. traumatol ; 62(3): 227-231, dic. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1435082


El tumor fibroblástico superficial de tejidos blandos positivo para antígeno CD34 (CD34) es un tumor raro, de baja frecuencia, que se caracteriza histológicamente por un marcado pleomorfismo, baja actividad mitótica, e inmunoreactividad difusa para CD34. Puede tener un comportamiento similar al de un tumor mesenquimal de malignidad intermedia. Existen sólo 52 casos publicados en la literatura. Se presenta el caso de una paciente de 31 años con una masa en tejidos blandos en región inguinal izquierda, de crecimiento progresivo, de varios meses de evolución dolorosa. La masa fue biopsiada y, con la sospecha de un tumor fibroblástico superficial positivo para CD34, fue posteriormente tratada con una resección ampliada de la lesión y con cobertura del defecto en la piel con un colgajo local de avance de V-Y, con una evolución satisfactoria en su seguimiento postquirúrgico. El reporte de patología confirmó la sospecha diagnóstica de un tumor con reactividad fuerte para CD34, con proteína P53 en 60% a 70%, antígeno Ki67 menor al 15%, sin pérdida de proteína nuclear INI-1, y negatividad para CD31, CD163, AE1AE3, CAM5.2, EMA, CD30, receptores de progestágenos, proteína S100, y desmina, con bordes negativos.

Superficial CD34 (CD34) antigen positive fibroblastic soft-tissue tumor is a rare, lowfrequency tumor, characterized histologically by marked pleomorphism, low mitotic activity, and diffuse immunoreactivity for CD34. It may behave like a mesenchymal tumor of intermediate malignancy. There are only 52 cases published in the literature. We present the case of a 31-year-old patient with a long progressive and painful growth of a soft-tissue lesion in the left inguinal region. The mass was biopsied and, with the suspicion of a superficial CD34-positive fibroblast tumor, it was subsequently treated with an enlarged resection of the lesion and covering the skin defect with a local V-Y advancement flap, with a satisfactory evolution in the postoperative follow-up. The pathology report confirmed the diagnostic suspicion of a tumor with strong reactivity for CD34, with P53 protein in 60% to 70%, Ki67 antigen in less than 15%, without loss of INI-1, and with negativity for CD31, CD163, AE1AE3, CAM5.2, EMA, CD30, progestin receptors, S100 protein and desmin, with negative borders.

Humans , Female , Adult , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/pathology , Antigens, CD34 , Skin Neoplasms/pathology
Rev. bras. cir. plást ; 32(4): 513-522, out.-dez. 2017. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-878769


Introdução: Apesar do avanço no diagnóstico e no tratamento das pacientes com neoplasia mamária, ainda há casos que se apresentam como doença localmente avançada. Nesse contexto, o controle oncológico requer ressecções extensas e complexos procedimentos reparadores. A participação do cirurgião plástico nas equipes multidisciplinares de tratamento oncológico tem apresentado importância crescente tanto nas etapas de planejamento como de execução. O objetivo é analisar prospectivamente casos de pacientes com extensas ressecções no tórax e reconstrução de parede torácica quanto aos seus resultados e complicações no período de 2014-2016. Métodos: Seguimento prospectivo por 6 meses de 15 casos de pacientes submetidas a extensas ressecções oncológicas no tórax e reconstrução por um mesmo cirurgião plástico em hospitais da rede pública de São Paulo-SP. Foram coletados os dados: idade, diagnóstico, queixa pré-operatória, extensão da área de ressecção e incidência de complicações locais. Resultados: As pacientes tinham idade média de 49,2 anos, a queixa mais comum era massa papável, o diagnóstico mais comum era neoplasia da mama (80%), a maioria das ressecções preservou o plano muscular e a área média de ressecção foi de 259,2 cm2. O retalho miocutâneo do grande dorsal em V-Y foi o mais utilizado, e o toracoabdominal foi o segundo. Epiteliólise foi detectada em 13,3% das pacientes e necrose parcial menor que 5% do retalho em 13,3%. Conclusão: Na presente casuística, as pacientes portadoras de neoplasias extensas no tórax representaram um desafio para a reconstrução local, necessitando de planejamento pré-operatório minucioso e com múltiplas opções. A participação do cirurgião plástico no tratamento desses casos contribuiu para redução de morbidade e demonstrou baixo índice de complicações.

Introduction: In spite of advances in the diagnosis and treatment of patients with breast cancer, there are still cases that present with locally advanced disease. In this context, cancer control requires extensive resections and complex repair procedures. The participation of the plastic surgeon in the multidisciplinary cancer treatment teams has been increasingly important in both the planning and execution stages. The aim of this study is to prospectively analyze patients who underwent extensive chest resections and thoracic wall reconstruction with regard to their results and complications in the period 2014-2016. Methods: Prospective 6-month follow-up of 15 patients who underwent extensive oncological resections in the chest and reconstruction by the same plastic surgeon in public hospitals of São Paulo was done. The following data were collected: age, diagnosis, preoperative complaint, extent of resection area, and incidence of local complications. Results: Patients had a mean age of 49.2 years, the most common complaint was a papillary mass, the most common diagnosis was breast cancer (80%), the most resection area preserved was the muscular plane, and the mean resection area was 259.2 cm2. The V-Y latissimus dorsi myocutaneous flap was the most used, and the thoracoabdominal flap was the second. Epitheliolysis was detected in 13.3% of the patients, and partial necrosis less than 5% of the flap in 13.3%. Conclusion: In the present study, patients with extensive cancers in the thorax presented a challenge for local reconstruction, requiring detailed preoperative planning and multiple options. The participation of the plastic surgeon in the treatment of these patients contributed to the reduction of morbidity rate and low rate of complications.

Humans , Female , Adult , Middle Aged , History, 21st Century , Postoperative Complications , Soft Tissue Neoplasms , Breast , Breast Neoplasms , Prospective Studies , Mammaplasty , Plastic Surgery Procedures , Thoracic Wall , Intraoperative Complications , Postoperative Complications/surgery , Soft Tissue Neoplasms/surgery , Breast/surgery , Breast Neoplasms/surgery , Breast Neoplasms/therapy , Mammaplasty/methods , Plastic Surgery Procedures/methods , Thoracic Wall/surgery , Intraoperative Complications/surgery
An. bras. dermatol ; 92(4): 546-549, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-886990


Abstract: Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.

Humans , Male , Adult , Soft Tissue Neoplasms/pathology , Lipoma/pathology , Liposarcoma/pathology , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/diagnosis , Biopsy , Buttocks/pathology , Diagnosis, Differential , Lipoma/surgery , Lipoma/diagnosis , Liposarcoma/surgery , Liposarcoma/diagnosis
Arq. bras. med. vet. zootec ; 69(1): 106-110, jan.-fev. 2017. ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-834124


Este trabalho descreve o diagnóstico e o tratamento instituído para um cão com um raro cisto ósseo aneurismático originado em tecido mole. O paciente foi apresentado para atendimento no Hospital de Clínicas Veterinárias da Universidade Federal do Rio Grande do Sul devido à dificuldade de locomoção, fraqueza nos membros pélvicos e disquesia havia 15 dias. Já estava recebendo tratamento medicamentoso sem sucesso. Ao exame clínico, notou-se aumento de volume sólido na região perineal direita, e foram solicitados exames complementares de imagem. A radiografia da região sugeriu hérnia perineal direita ou neoplasia. O cão foi encaminhado para cirurgia, na qual foi removida uma estrutura tumoral, arredondada, de aspecto ossificado. O exame histopatológico diagnosticou a estrutura como um cisto ósseo aneurismático em tecido mole, e o paciente recuperou-se totalmente após a excisão cirúrgica.(AU)

This paper describes the diagnosis and treatment of a dog with a rare aneurysmal bone cyst in soft tissue. The patient was attended in the Veterinary Clinic Hospital at the Fedral University of Rio Grande do Sul due to limited mobility, weakness in hind limbs, and dyschezia for 15 days. It was already receiving medical treatment without success. Upon clinical examination a solid increase volume in the right perineal region was detected, and complementary imaging tests were requested. Radiography of the region suggested right perineal hernia or neoplasia. The dog was submitted to surgery, and a rounded and ossified tumoral structure was removed. The histopathological exam diagnosed the structure as an aneurysmal bone cyst in soft tissue, and the patient recovered fully after surgical excision.(AU)

Animals , Male , Dogs , Bone Cysts, Aneurysmal/diagnosis , Bone Cysts, Aneurysmal/surgery , Soft Tissue Neoplasms/surgery , Perineum/pathology
Rev. bras. cir. plást ; 30(4): 668-673, sep.-dec. 2015. ilus
Article in English, Portuguese | LILACS | ID: biblio-1423


Introdução: O leiomioma cutâneo piloeretor (LCP) é um tumor benigno de pele, de incidência rara, proveniente do músculo eretor do pelo. Sua apresentação clínica mais frequente é o aparecimento de nódulos isolados ou em grande número. Em geral, são dolorosos, sensíveis ao frio, toque, pressão e à emoção. Vários agentes farmacológicos têm sido utilizados com algum sucesso para redução da dor e do desconforto local. Entretanto, em casos nos quais os sintomas dolorosos são intensos ou causam restrição social, a cirurgia torna-se uma abordagem alternativa a ser considerada. Neste artigo relatamos o caso de um paciente do sexo masculino, portador de múltiplos leiomiomas cutâneos na parede torácica anterior à esquerda e no abdome, bem como a terapêutica utilizada para seu caso. Métodos: O tratamento compreendeu a ressecção cirúrgica total da lesão, com fechamento da ferida com o uso de enxerto de pele parcial, retirado da região anterolateral da coxa direita. Resultados: A reconstrução imediata do defeito resultante, com enxerto de pele parcial, assegurou a cicatrização sem intercorrências. Após o tratamento, houve completa remissão do quadro doloroso, o que permitiu completa reintegração social do paciente, tendo sido alcançado ainda resultado estético aceitável. Conclusão: O LCP constitui patologia de difícil tratamento, embora tenha várias possibilidades terapêuticas. A ressecção cirúrgica completa de múltiplos leiomiomas cutâneos pode impedir a recorrência da doença, embora alguma recidiva local seja relatada na literatura.

Introduction: Cutaneous pilar leiomyoma (CPL) is a rare benign skin tumor arising from arrector pili muscles. Its most common clinical manifestation is the appearance of nodules that may either be isolated or clustered. In general, these tumors are painful and sensitive to cold, touch, pressure, and emotional stimuli. Several pharmacological agents have been used with some success to reduce local pain and discomfort. However, in cases with intensely painful symptoms or that cause social constraints to the patient, surgery becomes an alternative approach. Here, we report the case of a male patient with multiple cutaneous leiomyomas in the left anterior chest wall and abdomen, and the therapeutic approaches used for this case. Methods: The treatment included a complete surgical resection of the tumor and wound closure with partial skin graft taken from the anterolateral region of the right thigh. Results: The immediate reconstruction of the resulting defect with a partial skin graft ensured healing without complications. After the treatment, complete remission of the pain symptoms occurred, in addition to an acceptable aesthetic outcome, which allowed the full social reintegration of the patient. Conclusion: CPL is a disease that is difficult to treat; however, several therapeutic approaches can be used. The complete surgical resection of multiple cutaneous leiomyomas can prevent the recurrence of the disease, although some local recurrences have been reported in the literature.

Humans , Male , Adult , History, 21st Century , Scopolamine , Skin , Skin Neoplasms , Soft Tissue Neoplasms , Wounds and Injuries , Skin Transplantation , Plastic Surgery Procedures , Thoracic Wall , Clinical Study , Hip , Leiomyoma , Scopolamine/therapeutic use , Skin/injuries , Skin/pathology , Skin Neoplasms/surgery , Skin Neoplasms/pathology , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/complications , Wounds and Injuries/surgery , Wounds and Injuries/drug therapy , Skin Transplantation/methods , Plastic Surgery Procedures/methods , Thoracic Wall/surgery , Hip/surgery , Leiomyoma/surgery , Leiomyoma/pathology
Rev. otorrinolaringol. cir. cabeza cuello ; 75(3): 261-264, dic. 2015. ilus
Article in Spanish | LILACS | ID: lil-771699


En el siguiente artículo se presenta un caso clínico de un adolescente de 14 años que consulta por presentar un aumento de volumen supraclavicular derecho y cuyo diagnóstico final realizado mediante estudio histológico luego de exéresis de la masa, concluye ser un hibernoma. Considerando la infrecuencia con la que se presentan este tipo de tumores benignos de los tejidos blandos, presentamos una descripción, mediante revisión bibliográfica, de dicha patología.

In this article, we present a clinical case of a 14 years old teen who presented a su-pracavicular growing mass and whose diagnosis made by histologic examination after performing excision, proves to be a hibernoma. Given the infrequency with wich these types of benign tumors of the soft tissues occur, we present a description, based on a literature review of such pathology.

Humans , Male , Adolescent , Head and Neck Neoplasms/surgery , Head and Neck Neoplasms/diagnosis , Lipoma/surgery , Lipoma/diagnosis , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/diagnosis , Biopsy , Tomography, X-Ray Computed , Clavicle/surgery
Rev. bras. cir. plást ; 30(3): 477-481, 2015. ilus
Article in English, Portuguese | LILACS | ID: biblio-1163


O presente estudo tem o objetivo de apresentar um relato de caso sobre condroma extra-esquelético ou de partes moles, uma lesão rara e benigna diagnosticada através da clínica, radiologia e exame histopatológico. O paciente (24 anos) compareceu ao Setor de Ortopedia do Hospital Unimed Betim com queixa de aumento de volume no polegar esquerdo, indolor há aproximadamente um ano. Durante o exame físico verificou-se presença de uma lesão nodular, de consistência dura, móvel, indolor que não acarretava em alteração funcional do dedo. O paciente foi encaminhado para setor de radiologia do hospital onde foi realizado RX e posteriormente ultrasonografia e ressonância magnética do polegar esquerdo. Diante dos achados dos estudos de imagem a equipe optou pela biópsia excisional da lesão. O exame histopatológico confirmou o diagnóstico de condroma extra-esquelético. Os elementos definidores do condroma de partes moles são: 1) curso clinico benigno e sintomatologia frusta; 2) ausência de conexão entre o tumor e estruturas adjacentes como periosteo, capsula articular ou osso; 3) crescimento lento; 4) ausência de prevalência por sexo; 5) características radiológicas e histológicas do tumor. O diagnóstico raramente é aventado quando confrontamos tumores de partes moles das mãos. A excisão é simples e deve ser completa para se evitar recorrências. A avaliação histopatológica deve ser realizada para confirmação diagnóstica.

The present study presents a case report of extraskeletal chondroma or soft tissue chondroma, a rare and benign lesion, diagnosed by clinical findings, imaging studies and histopathological exam. The 24-year-old patient presented at the Orthopedics Section of Unimed Betim Hospital with a slow painless growth on the left thumb about 1 year ago. During the physical examination, a nodular lesion was noted; it had a hard consistency, was mobile and painless, and didn't cause functional impairment for the finger. The patient was referred to the imaging unit of the hospital, where an X-ray was performed; later on, ultrasound and magnetic resonance imaging of the left thumb was done. After the imaging studies, the medical team chose excisional biopsy of the lesion. The histopathological examination confirmed the diagnosis of extra-skeletal chondroma or soft-tissue chondroma. Soft tissue chondroma is usually not considered for a soft-tissue tumor of the hand. Excision is easy and must be complete if recurrences are to be avoided. Histopathological evaluation is required for the final diagnosis.

Soft Tissue Neoplasms , Surgical Procedures, Operative , Thumb , Case Reports , Chondroma , Histological Techniques , Finger Phalanges , Electromagnetic Radiation , Neoplasms , Soft Tissue Neoplasms/surgery , Surgical Procedures, Operative/methods , Thumb/surgery , Chondroma/surgery , Histological Techniques/methods , Finger Phalanges/surgery , Neoplasms/surgery
Clinics ; 69(9): 579-584, 9/2014. tab, graf
Article in English | LILACS | ID: lil-725406


OBJECTIVE: Unplanned excision of soft tissue sarcomas is common because benign soft tissue lesions are very frequent. This study evaluated the impact of unplanned resections on overall survival, local recurrence and distant metastasis in patients with soft tissue sarcomas of the extremities. METHODS: In total, 52 patients who were diagnosed with soft tissue sarcomas between May 2001 and March 2011 were analyzed in a retrospective study. Of these patients, 29 (55.8%) had not undergone previous treatment and the remaining 23 (44.2%) patients had undergone prior resection of the tumor without oncological planning. All subsequent surgical procedures were performed at the same cancer referral center. The follow-up ranged from 6 to 122 months, with a mean of 39.89 months. Age, lesion size and depth, histological grade, surgical margins, overall survival, local and distant recurrence and adjuvant therapies were compared. RESULTS: Residual disease was observed in 91.3% of the re-resected specimens in the unplanned excision group, which exhibited greater numbers of superficial lesions, low histological grades and contaminated surgical margins compared with the re-resected specimens in the planned excision group. No differences were observed in local recurrence and 5-year overall survival between the groups, but distant metastases were significantly associated with planned excision after adjustment for the variables. CONCLUSIONS: There was no difference between patients undergoing unplanned excision and planned excision regarding local recurrence and overall survival. The planned excision group had a higher risk of distant metastasis, whereas there was a high rate of residual cancer in the unplanned excision group. .

Adolescent , Adult , Aged , Aged, 80 and over , Humans , Middle Aged , Young Adult , Extremities/surgery , Sarcoma/surgery , Soft Tissue Neoplasms/surgery , Kaplan-Meier Estimate , Multivariate Analysis , Neoplasm Grading , Risk Factors , Sarcoma/mortality , Sarcoma/pathology , Soft Tissue Neoplasms/mortality , Soft Tissue Neoplasms/pathology , Treatment Outcome , Tumor Burden
Rev. bras. cir. plást ; 29(3): 346-351, jul.-sep. 2014. tab, ilus
Article in English, Portuguese | LILACS | ID: biblio-718


INTRODUÇÃO: Revisão da literatura sobre o retalho miocutâneo inferior do músculo trapézio, apresentando suas vantagens, técnica cirúrgica e complicações. MÉTODOS: Estudo de 19 casos tratados no INCA, através de técnica específica, e comparação dos dados com a literatura internacional. RESULTADOS: Todas as reconstruções atingiram seus objetivos, com correção dos defeitos em partes moles e pele. O efeito estético foi considerado bom pelos pacientes e pela equipe médica. Foi observada uma taxa de 21% de complicações. Não houve necrose ou infecção nos retalhos. Em relação às funções, 89,5% apresentaram função motora preservada e 10,5%, déficit funcional por acometimento tumoral do nervo acessório. CONCLUSÃO: A despeito do aprimoramento contínuo das técnicas microcirúrgicas, os retalhos miocutâneos pediculados ainda encontram indicações nas reconstruções após ressecções oncológicas alargadas. O retalho miocutâneo inferior do músculo trapézio é uma alternativa segura e aplicável para as reconstruções de partes moles das regiões cervicais lateral e posterior, da região lateral da cabeça, da região do ombro e para as regiões paraespinhal superior e paraescapulares.

INTRODUCTION: In this article, we present a literature review on the lower myocutaneous trapezius flap, and report its advantages, surgical technique, and complications. METHODS: We studied 19 patients treated at INCA with a specific technique, and compared the outcomes with those reported in the international literature. RESULTS: All reconstructions achieved the procedural objectives, and the defects of soft tissues and skin were repaired. The aesthetic outcome was considered satisfactory by the patients and medical staff. The rate of complications was 21%. No necrosis or signs of infection were detected in the flaps. Concerning the functions, 89.5% of patients preserved their motor function, whereas reduced functional movements were observed in 10.5% of the patients due to tumor invasion to the accessory nerve. CONCLUSIONS: Despite the continuous advancements in microsurgical techniques, pedicle myocutaneous flaps are still indicated for reconstruction procedures after extended cancer resections. The use of the lower trapezius myocutaneous flap is safe and represents a suitable option for the reconstruction of soft tissues of the lateral and posterior cervical regions, side of the head, shoulder, and upper paravertebral and parascapular regions.

Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , History, 21st Century , Soft Tissue Neoplasms , Thorax , Comparative Study , Medical Records , Review , Plastic Surgery Procedures , Evaluation Study , Myocutaneous Flap , Head , Neck , Soft Tissue Neoplasms/surgery , Medical Records/standards , Plastic Surgery Procedures/methods , Myocutaneous Flap/surgery , Head/surgery , Neck/surgery
Rev. bras. cir. plást ; 29(3): 319-323, jul.-sep. 2014. ilus
Article in English, Portuguese | LILACS | ID: biblio-711


O lipoblastoma é um tumor mesenquimal raro, composto de lipoblastos que continuam sua proliferação após o período pós-natal e que acometem, predominantemente, a população pediátrica. Apresenta prognóstico excelente, apesar do potencial de invasão local e do crescimento rápido. Os autores relatam o caso de uma paciente pediátrica portadora de volumosa lesão em antebraço direito, ocasionando importante comprometimento funcional do membro acometido. Aspectos relevantes no diagnóstico diferencial e manejo são discutidos neste trabalho, visto tratar-se de lesão com potencial risco incapacitante futuro, caso não manejada corretamente.

Lipoblastoma is a rare mesenchymal tumor occurring primarily in pediatric patients and formed by lipoblasts that proliferate after the postnatal period. Despite its potential for local invasion and rapid growth, its prognosis is excellent. In this study, we report the case of a pediatric patient with a ponderous lesion in the right forearm that caused considerable functional impairment of the affected limb. We also discuss the relevant aspects concerning the differential diagnosis and management of the disease, as it has the potential to cause incapacity without proper treatment.

Humans , Female , Infant , History, 21st Century , Soft Tissue Neoplasms , Surgery, Plastic , Wounds and Injuries , Review Literature as Topic , Adipose Tissue , Adipocytes , Evaluation Study , Lipoma , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/pathology , Surgery, Plastic/methods , Wounds and Injuries/surgery , Adipose Tissue/embryology , Adipose Tissue/metabolism , Adipocytes/physiology , Adipocytes/metabolism , Lipoblastoma , Lipoblastoma/surgery , Lipoblastoma/pathology , Lipoma/surgery , Lipoma/pathology
An. bras. dermatol ; 89(1): 147-149, Jan-Feb/2014. tab, graf
Article in English | LILACS | ID: lil-703540


Superficial Acral Fibromyxoma is a rare tumor of soft tissues. It is a relatively new entity described in 2001 by Fetsch et al. It probably represents a fibrohistiocytic tumor with less than 170 described cases. We bring a new case of SAF on the 5th toe of the right foot, in a 43-year-old woman. After surgical excision with safety margins which included the nail apparatus, it has not recurred (22 months of follow up). We carried out a review of the location of all SAF published up to the present day.

Adult , Female , Humans , Fibroma/pathology , Nail Diseases/pathology , Skin Neoplasms/pathology , Soft Tissue Neoplasms/pathology , Biopsy , Diagnosis, Differential , Fibroma/surgery , Nail Diseases/surgery , Skin Neoplasms/surgery , Soft Tissue Neoplasms/surgery , Treatment Outcome
Rev. Col. Bras. Cir ; 40(5): 427-429, set.-out. 2013. ilus
Article in Portuguese | LILACS | ID: lil-698082


Forequarter amputations are an uncommon option for the treatment of upper limb and shoulder girdle tumors nowadays. This procedure can be done by different approaches and general anesthesia is commonly used. The authors report a case of forequarter amputation by the posterior approach performed for treatment of a soft-tissue sarcoma under a brachial plexus block associated with venous sedation and local anesthesia.

Female , Humans , Middle Aged , Anesthesia, Conduction , Amputation, Surgical/methods , Arm/surgery , Sarcoma/surgery , Shoulder/surgery , Soft Tissue Neoplasms/surgery
Rev. bras. cir. plást ; 28(3): 522-525, jul.-set. 2013. ilus
Article in English, Portuguese | LILACS | ID: lil-776136


Lipomas are the most common mesenchymal tumors, which may develop in different parts of the body. However giant lipomas are rare and sometimes difflcult to diagnose owing to their location and the presenting clinical consequences. In this report, we present the case of a patient with a giant lipoma in lhe left popliteal region that was surgícally treated after a detailed radiologícal assessment. Further, we discuss lhe preoperative diagnosis and its difficulties, often caused by the deep localization of the tumor and the impossibility of obtaining a conclusive radiological diagnosis. Moreover, we describe the successful treatment, along with the step-by-step surgical approach and the final outcome achieved.

Os lipomas são os tumores Mesenquimais mais frequentes e podem ocorrer em diversas partes do corpo. Entretanto lipomas gigantes são raros por vezes de difícil diagnóstico, em decorrência de sua localização e com consequência clinicas. Neste artigo é apresentado um caso de lipoma gigante em região poplítea esquerda tratado cirurgicamente após detalhado estudo radiológico. São discutidos o diagnóstico pré-operatório e suas dificuldades, muitas vezes causadas pela localização profunda e pela impossibilidade de diagnóstico conclusivo pela imagem. O tratamento foi concluído com sucesso, sendo descritos a abordagem cirúrgica passo a passo e o resultado final.

Humans , Male , Aged , Adipocytes , Intraoperative Complications , Lipomatosis , Lymphoma/surgery , Mesoderm/surgery , Soft Tissue Neoplasms/surgery , Therapeutics , Diagnostic Techniques and Procedures , Methods , Neoplasms , Patients
Clinics in Orthopedic Surgery ; : 334-337, 2013.
Article in English | WPRIM | ID: wpr-34834


We present a rare case of glomus tumor of Hoffa's fat pad in a 42-year-old woman. Magnetic resonance imaging findings along with the characteristic clinical picture led us to suspect a glomus tumor as the possible etiology. An ischemia test was found to be positive and this further substantiated our diagnosis. An arthroscopic excision was performed and the histology confirmed the diagnosis of glomus tumor of Hoffa's fat pad. The patient responded well to the excision with immediate complete resolution of pain and she remains asymptomatic at the last follow-up after 15 months. To our knowledge, this is the second reported case of glomus tumor of Hoffa's fat pad and the first ever to be managed by simple arthroscopic excision. The tumor poses a great challenge to an orthopedic surgeon. However, knowledge of its characteristic clinical presentation and the recognition of such a rare entity can help achieve an early diagnosis and timely management.

Adult , Female , Humans , Adipose Tissue/pathology , Arthroscopy , Glomus Tumor/secondary , Knee/pathology , Magnetic Resonance Imaging , Soft Tissue Neoplasms/surgery
Rev. cuba. cir ; 50(3)jul.-sept. 2011. tab
Article in Spanish | LILACS | ID: lil-616271


Se revisan aspectos teóricos en los tumores primarios de la pared torácica, sobre todo en la clasificación y en aspectos clínicos, diagnósticos y terapéuticos, con el propósito de conocer los resultados del tratamiento en el centro. Se realizó un estudio retrospectivo descriptivo para analizar los resultados del tratamiento quirúrgico en 22 pacientes (muestra) con tumores primarios de la pared torácica, en un período de 15 años (enero de 1993 a diciembre de 2008), en los servicios de cirugía general y ortopedia del Hospital Amalia Simoni de Camagüey. Hubo ligero predominio del sexo femenino y del grupo de edad entre 17 a 44 años (media 39,4), la comorbilidad que predominó fue la hipertensión arterial, el hemitórax derecho fue el más afectado, y las costillas de la 1 a la 4 las más lesionadas, y predominaron las afecciones benignas, entre ellas, el osteocondroma. El tratamiento más utilizado fue la resección quirúrgica, y la complicación posoperatoria que predominó fue la bronconeumonía. El índice de recidiva tumoral fue alto, no siempre por cáncer. Hubo 4 fallecidos por enfermedad maligna avanzada, y no se presentaron muertes perioperatorias. Conclusiones: fueron comparados los resultados con los de otros reportes y se hallaron puntos de coincidencia en diversos aspectos, pero también discrepantes, se trata de unificar criterios para mejorar el diagnóstico y los resultados del tratamiento en estos enfermos. La mayoría de los pacientes no presentaron complicaciones, y la recidiva tumoral estuvo por encima de lo esperado. La resección tumoral siempre debe ser amplia. El resultado global fue satisfactorio(AU)

the theoretical features in the primary tumors of the thorax wall, especially in the classification and clinical, diagnostic y therapeutical features were reviewed to know the results of treatment in our institution. A descriptive and retrospective study was conducted to analyze the results of surgical treatment in 22 patients (sample) with primary tumors of the thorax wall during 15 years (from January,1993 to December, 2008) in the services of general surgery and orthopedics of the Amalia Simoni Hospital of the Camagüey province. There was a slight predominance of female sex and the age group from 17 to 44 years (mean, 39.4), the predominant comorbid disease was the high blood pressure, the right hemithorax was the more involved and the ribs from 1 to 4 were the more injured with predominance of benign affections including the osteochondroma. The treatment more applied was the surgical resection and the postoperative complication predominant was the bronchopneumonia. The tumor relapse rate was high but not always due to cancer. The were 4 deceased due to advanced malignant disease without perioperative deaths. Conclusions: results were compared to other reports with coincidence points in different features but also differing and try to unify criteria to improve diagnosis y the results of treatment of these patients. Most of patients were without complications and the tumor relapse was over the expected. The tumor resection always must to be wide. Global result was satisfactory(AU)

Humans , Female , Adult , Soft Tissue Neoplasms/surgery , Osteochondroma/surgery , Thoracic Wall/diagnostic imaging , Epidemiology, Descriptive , Retrospective Studies
Rev. bras. cir. plást ; 26(3): 418-427, July-Sept. 2011. ilus
Article in English, Portuguese | LILACS | ID: lil-608199


BACKGROUND: Pressure ulcers are defined as lesions of ischemic etiology in the skin or soft tissue. These lesions are secondary to increased external pressure and usually occur over bony prominences. Classification of various stages of pressure ulcers is important for the development of therapeutic strategies. The fundamental surgical treatments are debridement and excision of underlying bursa and involved bone tissue, followed by tissue coverage. This study reports our experience in repairing pressure ulcers and analyzes patient characteristics, outcomes, and complications. METHODS: A total of 33 pressure ulcers were treated in 17 patients, the most prevalent of which was sacral ulcer. The development of pressure ulcers in hospitals accounted for 82 percent of the cases. Treatment options included debridement, primary synthesis, random skin flaps, rhomboid skin flap, myocutaneous flaps of the gluteus maximus in V-Y, classic fasciocutaneous flaps of fascia lata, fasciocutaneous flap of fascia lata in V-Y, and posterior fasciocutaneous flaps of the thigh in V-Y. RESULTS: Complications occurred in 39 percent of cases. Preoperative anemia was associated with complications. CONCLUSIONS: Pressure ulcers can be avoided in most cases, given sufficient knowledge of their pathogenesis and correct management of patients at risk. Multi-professional and family participation is essential for the treatment of patients with pressure ulcers since complications, recurrence, and the incidence of new ulcers are common. Complication risk factors such as anemia should be avoided in order to provide a better prognosis and proper closure of the ulcer.

INTRODUÇÃO: Úlceras por pressão são definidas como lesões cutâneas ou de partes moles de etiologia isquêmica, secundárias ao aumento da pressão externa, predominando sobre proeminência óssea. A classificação em estágios é importante na elaboração de estratégias terapêuticas. Os princípios fundamentais no tratamento cirúrgico são: debridamento e exérese de bursa subjacente e tecido ósseo envolvido, seguida de cobertura tecidual. Este estudo teve por objetivo relatar a experiência em reparação de úlceras por pressão, analisando características dos pacientes, resultados e complicações. MÉTODO: Em 17 pacientes, foram tratadas 33 úlceras por pressão, sendo a localização sacral a mais prevalente. O desenvolvimento de úlceras por pressão no ambiente hospitalar correspondeu a 82 por cento dos casos. As opções de tratamento foram: debridamento, síntese primária, retalhos cutâneos ao acaso, retalho cutâneo romboide, retalhos miocutâneos de glúteo máximo em V-Y, retalhos fasciocutâneos de fascia lata clássicos, retalho fasciocutâneo de fascia lata em V-Y, e retalhos fasciocutâneos posteriors da coxa em V-Y. RESULTADOS: Complicações ocorreram em 39 por cento dos casos. A anemia pré-operatória foi associada a complicações. CONCLUSÕES: O conhecimento da patogênese da úlcera por pressão e o correto manejo do paciente de risco podem evitá-la na maioria dos casos. É indispensável a participação multiprofissional e dos familiares para o tratamento do paciente portador de úlcera por pressão, pois complicações, recidivas e incidência de novas úlceras são comuns. Fatores de risco para complicações, como anemia, devem ser evitados, para obtenção de melhor prognóstico e fechamento adequado da úlcera.

Humans , Male , Adult , Middle Aged , Aged , History, 21st Century , Postoperative Complications , Soft Tissue Neoplasms , Surgical Flaps , Ulcer , Buttocks , Risk Factors , Pressure Ulcer , Anemia , Intraoperative Complications , Postoperative Complications/therapy , Soft Tissue Neoplasms/surgery , Soft Tissue Neoplasms/therapy , Surgical Flaps/surgery , Ulcer/surgery , Buttocks/surgery , Pressure Ulcer/surgery , Pressure Ulcer/etiology , Anemia/complications , Anemia/therapy , Intraoperative Complications/therapy