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1.
San Salvador; MINSAL; may. 11, 2022. 47 p. tab.
Non-conventional in Spanish | LILACS, BISSAL | ID: biblio-1372447

ABSTRACT

El presente Plan nacional contra la resistencia a los antimicrobianos, tiene como objetivo prevenir las enfermedades infecciosas, asegurando el uso adecuado de los tratamientos con medicamentos eficaces, seguros y de calidad garantizada, que se usen de modo responsable, tanto para el tratamiento de enfermedades infecciosas en humanos y animales, así como para garantizar la producción de alimentos. Este Plan se construye bajo la visión de «Una Salud¼ en el plano internacional, la OMS colabora estrechamente con la Organización de las Naciones Unidas para la Alimentación y la Agricultura (FAO) y la Organización Mundial de Sanidad Animal (OIE) para proponer soluciones viables a los peligros y riesgos generados por el uso inadecuado de antibióticos en la producción de alimentos de origen animal. En este plan nacional se contempla la participación de diversas instituciones relacionadas con la prestación de servicios de salud, producción de alimentos e instituciones formadoras de recursos humanos en salud, coordinadas todas por la Comisión Nacional contra la Resistencia a Antimicrobianos


This National Plan against antimicrobial resistance aims to prevent infectious diseases, ensuring the proper use of treatments with effective, safe and quality-guaranteed medicines, which are used responsibly, both for the treatment of infectious diseases in humans and animals, as well as to guarantee food production. This Plan is built under the vision of "One Health" at the international level, the WHO collaborates closely with the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (OIE) to propose solutions viable to the dangers and risks generated by the inappropriate use of antibiotics in the production of food of animal origin. This national plan contemplates the participation of various institutions related to the provision of health services, food production and training institutions for human resources in health, all coordinated by the National Commission against Antimicrobial Resistance


Subject(s)
Pharmaceutical Preparations , Health Services Programming , Anti-Infective Agents , Anti-Bacterial Agents , Solutions , Therapeutics , Health , El Salvador , Food
2.
Dent. press endod ; 11(2): 11-17, maio-ago.2021.
Article in Portuguese | LILACS | ID: biblio-1372773

ABSTRACT

A indicação das soluções anestésicas nos tratamentos endodônticos de rotina deve estar fundamentada nos conhecimentos dos possíveis efeitos que essas substâncias podem desencadear no paciente sistemicamente comprometido. Objetivo: O objetivo do presente estudo foi priorizar a indicação e discutir os possíveis efeitos secundários ou adversos passíveis de ocorrência com as substâncias que compõem as soluções anestésicas durante a rotina de tratamento dos canais radiculares (AU).


The indication of anesthetic solutions in routine endodontic treatments must be based on knowledge of the possible effects that these substances can trigger in systemically compromised patients. Aim: The aim of the present study was to prioritize the indication and discuss the possible secondary or adverse effects likely to occur with the use of substances of which anesthetic solutions are composed, during the routine treatment of root canals (AU).


Subject(s)
Humans , Root Canal Therapy , Anesthetics , Solutions/adverse effects
3.
Rev. colomb. gastroenterol ; 36(1): 39-50, ene.-mar. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1251520

ABSTRACT

Resumen Los parámetros de calidad para endoscopia digestiva alta han introducido indicadores intraprocedimiento, dentro de los cuales la adecuada visibilidad de la mucosa, libre de saliva, moco o burbujas, puede aumentar la posibilidad de detección de lesiones en fase temprana. Sin embargo, el uso de mucolíticos y antiburbujas ha mostrado gran variabilidad de eficiencia según las soluciones, concentraciones, tiempos de exposición y escala de visibilidad aplicados. Objetivos: determinar la efectividad de diferentes soluciones de premedicación para la limpieza de la mucosa digestiva; validar, mediante una prueba de concordancia interobservador, una nueva escala de adecuada visualización de la mucosa (TVMS) para el esófago, estómago y duodeno; y reportar eventos adversos o complicaciones relacionadas con las soluciones utilizadas y los procedimientos realizados. Material y métodos: estudio de cohortes prospectivas comparativas. Se incluyeron 412 pacientes adultos, ASA I y ASA II, para endoscopia diagnóstica bajo sedación consciente, distribuidos en 6 cohortes similares, divididas en dos grupos: no premedicación, 2 cohortes C1 (ayuno de 6 a 8 horas)y C2 (agua 100 mL); premedicación, 4 cohortes C3 a C6 (C3: agua 100 m L + simeticona 1000 mg; C4: agua 100 mL + simeticona 200 mg + N-acetilcisteína 600 mg; C5: agua 100 mL + simeticona 200 mg + N-acetilcisteína 1000 mg; C6: agua 100 mL + simeticona 200 mg + Hedera helix 70 mg). Se ingirió la solución 15 a 30 minutos antes del paso por cricofaríngeo. Se realizó la prueba de Kappa para medir la concordancia interobservador de la escala TVMS. Resultados: De 412 pacientes, 58% fueron de sexo femenino; 23% (136) fue de cohortes C1 y C2 y 67% (276) fue de cohortes C3 a C6. El tiempo medio de exposición a cada solución fue de 24,4 minutos. El volumen de lavado para lograr una adecuada visualización fue significativamente diferente entre ambos grupos: en los pacientes con premedicación se utilizaron 75,6 mL, mientras que en los pacientes sin premedicación se utilizaron 124 mL (p = 0,000), con una calidad de TVMS excelente de 88,7% frente al 41,4%, respectivamente. La cohorte C4 (agua 100 mL + simeticona 200 mg + N-acetilcisteína 600 mg) mostró ser la más efectiva con una diferencia significativa (p = 0,001) frente a C1 (ayuno) y C2 (placebo con agua 100 mL), y también tuvo una eficiencia superior frente a C3, C5 y C6 en su orden. No se presentaron eventos adversos o complicaciones en relación con la endoscopia, la sedación y los productos usados en la premedicación. Conclusiones: la solución más efectiva como premedicación para lograr una excelente visibilidad de la mucosa digestiva correspondió a la cohorte C4 (SIM 200 + NAC 600 + H2O 100 mL). La escala TVMS propuesta es una herramienta muy completa y fácil de aplicar por más de un observador. La premedicación ingerida, con antiburbuja, mucolítico y agua hasta 100 mL, entre 15 y 30 minutos previos a endoscopia, es segura en las condiciones descritas en este estudio.


Abstract Quality parameters for upper gastrointestinal endoscopy have introduced intraprocedural indicators, including adequate mucosal visualization free of saliva, mucus, or bubbles, which may increase the possibility of early-stage injury detection. The use of mucolytics and anti-foaming agents has shown great efficiency variability depending on the type of solution, concentrations, exposure times and visibility scale applied. Objectives: To determine the effectiveness of different premedication solutions for cleaning the digestive mucosa; to validate, by means of an interobserver concordance test, a new scale for the adequate visualization of the mucosa (TVMS) for the esophagus, stomach, and duodenum; and to report adverse events or complications associated with the solutions used and the procedures performed. Material and methods: Prospective, comparative cohort study. 412 adult patients, ASA I and ASA II, were included for diagnostic endoscopy under conscious sedation. They were distributed in 6 similar cohorts and divided into two groups: non-premedication, 2 in C1 (fasting 6 to 8 hours) and C2 (water 100 mL) cohorts; premedication, 4 C3 to C6 cohorts (C3: water 100 mL + simethicone 1000 mg; C4: water 100 ml + simethicone 200 mg + N-acetylcysteine 600 mg; C5: water 100 ml + simethicone 200 mg + N-acetylcysteine 1000 mg; C6: water 100 ml + simethicone 200 mg + Hedera helix 70 mg). The solution was swallowed 15 to 30 minutes passing through the cricopharyngeus muscle. The Kappa test was performed to measure interobserver concordance of the TVMS scale. Results: Of 412 patients, 58% were female; 23% (136) were included in the C1 and C2 cohorts; and 67% (276) were in the C3 to C6 cohorts. The average exposure time to each solution was 24.4 minutes. The wash volume for proper visualization was significantly different between the two groups. In premedicated patients, 75.6 mL of solution were used, while in patients without premedication, 124 mL were used (p = 0.000), with an excellent quality of TVMS of 88.7% versus 41.4%, respectively. The C4 cohort (water 100 mL + simethicone 200 mg + N-acetylcysteine 600 mg) was the most effective with a significant difference (p= 0.001) compared with the C1 (fasting) and C2 (placebo with water 100 mL) cohorts. It also had better efficiency compared to the C3, C5 and C6 cohorts in that order. There were no adverse events or complications associated with endoscopy, sedation, or premedication products. Conclusions: The most effective solution as a premedication to achieve excellent visibility of the digestive mucosa was that used in the C4 cohort (SIM 200 + NAC 600 + H2OR 100 mL). The proposed TVMS scale is a very complete and easy tool to apply by more than one observer. Premedication ingested, with anti-foam, mucolytic and water up to 100 mL, between 15 and 30 minutes before endoscopy, is safe under the conditions described in this study.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Premedication , Acetylcysteine , Simethicone , Hedera , Solutions , Endoscopy, Gastrointestinal
4.
Conexões (Campinas, Online) ; 19: e021006, 2021.
Article in Portuguese | LILACS | ID: biblio-1343221

ABSTRACT

Objetivo: analisar as competências profissionais dos árbitros internacionais de Bocha Paralímpica que atuaram nos Jogos Paralímpicos Rio 2016. Metodologia: Participaram do estudo onze árbitros, em que forneceram informações por meio de questionário online. Resultados e discussão: Os resultados apontam que as competências profissionais se caracterizaram pelo domínio das regras, estudo da modalidade, troca de informações entre os pares, participação no comitê de árbitros, domínio da regra no idioma oficial da modalidade, participação em competições internacionais. Conclusão: Com estes dados, foi possível aplicá-los no modelo de competências profissionais de Cheetham e Chivers(1996), em que descreve a competência cognitiva, funcional, pessoal e social e valores e ética, e, as metacompetências caracterizada pela competência que podem auxiliar na obtenção ou análise de outras competências, sendo estas atribuídas pela comunicação, autodesenvolvimento, criatividade, análise, solução de problemas, reflexão e agilidade mental.


Objective: The objective was to analyzethe professional skills of the international Boccia referees who participated in the Rio 2016 Paralympic Games. Methodology: Eleven referees participated in the study, in which they provided information through an online questionnaire. Results: The results show that professional competences were characterized by the mastery of the rules, study of the modality, exchange of information between peers, participation in the committee of referees, mastery of the rule in the official language of the modality, participation in international competitions. Conclusion: With these data, it was possible to apply them in the model of professional competences of Cheetham and Chivers (1996), in which it describes the cognitive, functional, personal and social competence and values and ethics, and the metacompetences characterized by the competence that can assist in the obtaining or analyzing other competences, which are attributed by communication, self-development, creativity, analysis, problem solving, reflection and mental agility.


Objetivo: El objetivo fue analizar las habilidades profesionales de los árbitros internacionales de Bochas Paralímpicas que participaron en los Juegos Paralímpicos de Río 2016. Metodología:En el estudio participaron once árbitros, en el que brindaron información a través de un cuestionario en línea. Resultados: Los resultados muestran que las competencias profesionales se caracterizaron por el dominio de las reglas, estudio de la modalidad, intercambio de información entre pares, participación en el comité de árbitros, dominio de la regla en el idioma oficial de la modalidad, participación en competencias internacionales. Conclusión: Con estos datos, fue posible aplicarlos en el modelo de competencias profesionales de Cheetham y Chivers (1996), en el que se describenlas competencias y valores cognitivos, funcionales, personales y sociales y la ética, y las metacompetencias caracterizadas por la competencia que puede ayudar en la obtener o analizar otras habilidades, que se atribuyen a la comunicación, el autodesarrollo, la creatividad, el análisis, la resolución de problemas, la reflexión y la agilidad mental.


Subject(s)
Humans , Professional Competence , Sports for Persons with Disabilities , Solutions , Communication , Creativity , Cultural Competency , Social Skills , Occupational Groups
5.
Psicol. ciênc. prof ; 41(spe3): e190115, 2021.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1340450

ABSTRACT

Resumo O artigo apresenta resultados de pesquisa em que se objetivou circunscrever e analisar a argumentação sustentada por profissionais de diferentes setores da sociedade que apoiam e divulgam a denominada "nova cultura da adoção". Ela se constitui em um conjunto de ideias que vêm sendo instauradas no Brasil desde os anos oitenta pelo movimento nacional de adoção, visando estimulá-la em nome do direito à convivência familiar e comunitária de crianças e adolescentes institucionalizados. A partir de uma pesquisa documental que teve como fonte de dados sete palestras apresentadas no I Congresso Nacional Online de Adoção, em 2015, emergiram cinco categorias que foram avaliadas por meio de análise de conteúdo. Concluiu-se que o discurso atual sobre a "nova cultura da adoção" enaltece a adoção enquanto solução para garantir os direitos do público infanto-juvenil, desconsiderando, porém, condicionantes socioeconômicos que atingem suas famílias de origem, que contribuem para sua disfuncionalidade e consequente destituição de seu poder familiar sobre a prole. Nesta perspectiva, a "nova cultura da adoção" muitas vezes desqualifica e culpabiliza as famílias de origem pela institucionalização dos filhos, enquadrando-se na lógica neoliberal vigente, à medida que prioriza a substituição pelos pais adotivos e não a reabilitação da organização familiar de origem por meio de investimento em políticas sociais eficazes desenvolvidas pelo Estado.(AU)


Abstract This paper presents the results of a research aimed to delimit and analyze the arguments presented by professionals from different social sectors who support and disseminate the so-called "new culture of adoption". This term designates a set of ideas that have emerged with the Brazilian national movement for adoption ever since the 1980s, encouraging the adoption of institutionalized children and teenagers, as well as their right to familiar and communitarian interaction. Five evaluation categories were obtained from on a Content Analysis of seven lectures presented in the 2015 National Adoption Conference. The results indicate that the current discourse of the "new culture of adoption" praises adoption as a solution to guarantee the rights of institutionalized children and teenagers. However, such understanding disregards the socioeconomic conditions of families of origin, which contribute to their dysfunctions and the consequent withdrawal of their legal authority upon their child. In this perspective, the "new culture of adoption" often disqualifies and blames the families of origin for the institutionalization of their children, thus being framed within the current neoliberal logic for it prioritizes the substitution of the biological family by adoptive parents rather than its rehabilitation through investment in effective social policies.(AU)


Resumen Este artículo presenta los resultados de la investigación cuyo objetivo fue delimitar y analizar la argumentación sostenida por profesionales de diferentes sectores de la sociedad que apoyan y divulgan la denominada "nueva cultura de la adopción". Se trata de un conjunto de ideas que son instauradas en Brasil, desde los años ochenta, por el movimiento nacional de adopción, con el fin de estimularla en nombre del derecho a la convivencia familiar y comunitaria de niños y adolescentes institucionalizados. Con base en una investigación documental que tuvo como fuente de datos siete charlas presentadas en el I Congreso Nacional online de Adopción, en 2015, surgieron cinco categorías, que fueron evaluadas por medio de análisis de contenido. Se concluyó que el discurso actual sobre la "nueva cultura de la adopción" enaltece la adopción como una solución para garantizar los derechos de este público infanto-juvenil, desconsiderando limitaciones socioeconómicas que afectan a sus familias de origen y contribuyen a la disfuncionalidad de estas y la consiguiente destitución de su poder familiar sobre la prole. En esta perspectiva, la "nueva cultura de la adopción" muchas veces descalifica a las familias de origen y las culpa por la institucionalización de los hijos, encuadrándose en la lógica neoliberal vigente en la medida en que prioriza la sustitución de las mismas por los padres adoptivos en vez de la rehabilitación de la organización familiar por medio de inversiones del Estado en políticas sociales eficaces.(AU)


Subject(s)
Humans , Male , Female , Social Isolation , Adoption , Family , Poverty , Psychology , Social Class , Societies , Solutions , Child, Abandoned , Child Development , Child, Institutionalized , Lecture , State , Malpractice
6.
Psicol. ciênc. prof ; 40: e215231, jan.-maio 2020.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1143527

ABSTRACT

Resumo Na perspectiva da teoria enativa da cognição, uma habilidade pode ser compreendida como uma relação flexível de um organismo com aspectos de seu ambiente de modo que ele possa agir de forma bem sucedida. Por sua vez, o conceito de políticas cognitivas nos ajuda a compreender como habilidades são promovidas e distribuídas em diversos contextos. Consideramos que os modelos de avaliação da produtividade acadêmica promovem arranjos que tendem a enfatizar um plano no qual os resultados ganham maior relevância na escala produtiva do que o desmembramento das "soluções" já existentes em problemas. Sendo assim, o objetivo deste artigo é entender o modo como as formas de avaliação dos programas de pós-graduação no Brasil podem modular noções de habilidades acadêmicas - hoje baseadas, principalmente, em publicações, invisibilizando outros processos que envolvem a produção de conhecimento e a experiência do pesquisador. Para tanto, realizamos uma pesquisa-intervenção junto a estudantes de cinco programas de pós-graduação de universidades públicas e privadas, na qual foram utilizados os procedimentos de entrevistas semiestruturadas e oficinas de fotografia. Por meio das entrevistas com as estudantes de engenharia e o estudante da veterinária, destacadas neste artigo, percebemos como o funcionamento acadêmico pressupõe a habilidade de pesquisar como um atributo que pertence ao indivíduo e reconhece/visibiliza em maior quantidade as habilidades consagradas nas sessões de procedimentos em métodos de artigos científicos, tratando como expert aquele que reproduz com precisão modos de fazer previamente especificados.


Abstract From the perspective of the enative theory of cognition, an ability can be understood as a flexible relationship of an organism with aspects of its environment so that it can act in a successful way. In turn, the concept of cognitive policies allows to understand how skills are promoted and distributed in diverse contexts. We consider that the models of evaluation of academic productivity promote more relevant results than transformation of existing "solutions" into problems. The objective of this article is to understand how the forms of evaluation of graduate programs in Brazil modulate a notion of academic abilities based, mainly, in publications, decreasing the importance of other processes involving the production of knowledge and the experience of the researcher. For such, we conducted an intervention research with students from five graduate programs of public and private universities utilizing semi-structured interviews and photography workshops. The results show how academic functioning assumes the ability to research as an attribute that belongs to the individual. They emphasise the abilities acknowledged only in scientific methods, considering as experts students able to reproduce standard practices.


Resumen En la perspectiva de la teoría enactiva de la cognición, una habilidad se entiende como una relación flexible de un organismo con aspectos de su ambiente para que pueda actuar de forma exitosa. Por su parte, el concepto de políticas cognitivas nos ayuda a comprender cómo las habilidades son promovidas y distribuidas en diversos contextos. Consideramos que los modelos de evaluación de la productividad académica promueven arreglos que tienden a enfatizar un plan en el cual los resultados ganan mayor relevancia en la escala productiva que el desmembramiento de las "soluciones" ya existentes en problemas. Ante esto, el objetivo de este artículo fue entender cómo las formas de evaluación de los programas de posgrado en Brasil pueden modular nociones de habilidades académicas, basadas actualmente en publicaciones, invisibilizando otros procesos que involucran la producción de conocimiento y la experiencia del investigador. Para ello, realizamos una investigación-intervención junto a estudiantes de cinco programas de posgrado de universidades públicas y privadas, en la cual se utilizaron los procedimientos de entrevistas semiestructuradas y talleres de fotografía. De las entrevistas con las estudiantes de ingeniería y el estudiante de veterinaria, destacadas en este artículo, percibimos cómo el funcionamiento académico presupone la habilidad de investigar como un atributo que pertenece al individuo y reconoce/posibilita en mayor cantidad las habilidades más consagradas en las sesiones de procedimientos en métodos de artículos científicos tratando como experto aquel que reproduce con precisión modos de hacer previamente especificados.


Subject(s)
Humans , Male , Female , Research , Students , Veterinary Medicine , Interview , Cognition , Engineering , Policy , Powders , Publications , Research Personnel , Solutions , Universities , Photography , Knowledge , Growth and Development , Education
7.
Dent. press endod ; 10(1): 27-31, Jan-Apr2020.
Article in English | LILACS | ID: biblio-1344084

ABSTRACT

Avaliar, por microscopia eletrônica de varredura (MEV), o efeito do uso individual e combinado do etidronato 18% (HEBP) na remoção da smear layer do canal radicular. Métodos: Trinta dentes humanos unirradiculares foram utilizados. As raízes foram preparadas com instrumentos rotatórios do Sistema ProTaper Universal e divididas aleatoriamente em três grupos, de acordo com o protocolo de irrigação empregado: G1 = hipoclorito de sódio 2,5% (NaOCl) e ácido etilenodiaminotetracético 17% (EDTA); G2 = NaOCl 2,5% e HEBP 18%; e G3 = NaOCl 2,5% + HEBP 18%, misturados em partes iguais. As raízes foram seccionadas longitudinalmente e metalizadas, para análise em MEV. As fotomicrografias obtidas dos terços cervical, médio e apical foram avaliadas por três examinadores calibrados, que atribuíram escores de 1 a 5 às imagens. Os grupos experimentais foram comparados usando o teste de Kruskal-Wallis e o teste de Student-New- man-Keuls. Os terços radiculares foram comparados pelo teste de Friedman. O nível de significância foi estabelecido em 5%. Resultados: A capacidade de remoção da smear layer com NaOCl 2,5% e 18% HEBP (G2) foi semelhante à obtida com NaOCl 2,5% e EDTA 17% (G1) no terço médio e cervical da raiz; o nível de limpeza do terço apical foi semelhante, independentemente do protocolo de irrigação utilizado. Conclusão: HEBP é uma solução promissora para uso em tratamentos endodônticos (AU).


Introduction: We evaluated the effect of individual and combined use of 18% etidronate (HEBP) in root canal smear layer removal using scanning electron microscopy (SEM). Methods: Thirty human single-rooted teeth were used. The roots were prepared with ProTaper Universal System rotary files and randomly divided into three groups according to the irrigation protocol used. G1: 2.5% sodium hypochlorite (NaOCl) and 17% ethylenediaminetetraacetic acid (EDTA); G2: 2.5% NaOCl and 18% HEBP; and G3: 2.5% NaOCl + HEBP 18%, mixed in equal parts. The roots were sectioned longitudinally and metallized for SEM analysis. The photomicrographs obtained from the cervical, middle, and apical thirds were evaluated by three calibrated examiners, who assigned scores from 1 to 5 to the images. The experimental groups were compared using the Kruskal-Wallis test and the Student-Newman-Keuls test. Root thirds were compared by the Friedman test. The level of significance was set at 5%. Results: The capacity for removal of the smear layer by 2.5% NaOCl and 18% HEBP (G2) was similar to that achieved with 2.5% NaOCl and 17% EDTA (G1) in the cervical and middle thirds of the root; the cleansing level of the apical third was similar, regardless of the irrigation protocol used. Conclusion: HEBP is a promising solution for use in endodontic treatments (AU).


Subject(s)
Humans , Microscopy, Electron, Scanning , Etidronic Acid , Lifting , Dental Pulp Cavity , Solutions , Efficacy , Dissolution , Organic Matter
8.
Braz. J. Pharm. Sci. (Online) ; 56: e18411, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132049

ABSTRACT

Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder cancer cell line and antimicrobial effect was evaluated on E. coli, S. aureus and C. albicans. One of the formulations (10% w/w of F127 and 5000 µM of resveratrol) was a monodispersed solution with high encapsulation rate, thus it was chosen for the cytotoxicity and antimicrobial assays. MS- 10+RES-3 was able to preserve the antimicrobial and cytotoxic activity of resveratrol. This is the first study that evaluated antimicrobial potential and cytotoxicity of micelles containing resveratrol on bladder cancer cells and the results showed that micellar nanostructures could ensure the maintenance of the biological activity of resveratrol.


Subject(s)
Urinary Bladder Neoplasms , Cells , Resveratrol/analysis , Neoplasms/pathology , Solutions/administration & dosage , In Vitro Techniques/instrumentation , Cell Line/classification , Vitis/classification , Hydrogen-Ion Concentration , Micelles
9.
Einstein (Säo Paulo) ; 17(2): eAO4328, 2019. tab, graf
Article in English | LILACS | ID: biblio-1001902

ABSTRACT

ABSTRACT Objective: To compare the enzyme activity of different presentations of papain solution to validate in-house preparations. Methods: Two papain solutions were prepared, and the third presentation was a commercial solution. Tests were carried out with samples of red cells typed as weak RhD. Results: In-house prepared papain solutions showed similar enzyme reactivity, and statistically no differences compared to the enzyme activity of the commercial solution. Conclusion: Evaluating the cost-benefit ratio, the in-house prepared papain solutions present more economic advantages, and can be incorporated into immunohematological routines as a way to cope with periods of financial crisis and cost-containment policies.


RESUMO Objetivo: Comparar a atividade enzimática de diferentes apresentações de solução de papaína para validação de preparados in-house. Métodos: Foram preparadas duas soluções de papaína, e a terceira apresentação tratou-se de uma solução comercial. Os testes comparativos das reações enzimáticas foram realizados com amostras de hemácias tipadas como RhD fraco. Resultados: As soluções de papaína preparadas in-house apresentaram reatividade enzimática semelhante e estatisticamente sem diferenças em comparação com a atividade enzimática da solução comercial. Conclusão: Avaliando-se a relação entre custo e benefício, as soluções de papaína preparadas in-house são economicamente vantajosas, podendo ser incorporadas às rotinas imuno-hematológicas como forma de enfrentamento em períodos de crise financeira e em políticas de retenção de gastos.


Subject(s)
Humans , Peptide Hydrolases/chemistry , Solutions/standards , Papain/chemistry , Erythrocytes/enzymology , Hematologic Tests/standards , Peptide Hydrolases/economics , Rh-Hr Blood-Group System/economics , Rh-Hr Blood-Group System/chemistry , Solutions/economics , Time Factors , Agglutination Tests/methods , Papain/economics , Reproducibility of Results , Hematologic Tests/economics
10.
Braz. dent. j ; 28(5): 624-631, Sept.-Oct. 2017. tab, graf
Article in English | LILACS | ID: biblio-888690

ABSTRACT

Abstract The aim of this study was to evaluate the degree of conversion, color stability, chemical composition, and bond strength of a light-cured resin cement contaminated with three different hemostatic solutions. Specimens were prepared for the control (uncontaminated resin cement) and experimental groups (resin cement contaminated with one of the hemostatic solutions) according to the tests. For degree of conversion, DC (n = 5) and color analyses (n = 10), specimens (3 mm in diameter and 2 mm thick) were evaluated by Fourier transform infrared spectroscopy (FTIR) and CIELAB spectrophotometry (L*, a*, b*), respectively. For elemental chemical analysis (n = 1), specimens (2 mm thick and 6 mm in diameter) were evaluated by x-ray energy-dispersive spectroscopy (EDS). The bond strengths of the groups were assessed by the microshear test (n = 20) in a leucite-reinforced glass ceramic substrate, followed by failure mode analysis by scanning electron microscopy (SEM). The mean values, except for the elemental chemical evaluation and failure mode, were evaluated by ANOVA and Tukey's HSD test. The color stability was influenced by storage time (p<0.001) and interaction between contamination and storage time (p<0.001). Hemostop and Viscostat Clear contamination did not affect the DC, however Viscostat increased the DC. Bond strength of the resin cement to ceramic was negatively affected by the contaminants (p<0.001). Contamination by hemostatic agents affected the bond strength, degree of conversion, and color stability of the light-cured resin cement tested.


Resumo O objetivo desse estudo foi avaliar o grau de conversão, estabilidade de cor, composição química e resistência de união de um cimento resinoso fotoativado contaminado com três soluções hemostáticas diferentes. Foram preparadas amostras para o grupo controle (cimento não contaminado) e grupos experimentais (cimento contaminado com uma das soluções hemostáticas) de acordo com os testes. Para o grau de conversão e análise de cor (n=10), as amostras (3 mm de diâmetro e 2 mm de espessura) foram avaliadas por espectroscopia de infravermelho com transformação de Fourier (FTIR) e espectrofotometria CIELAB (L*, A*, B*), respectivamente. Para a análise química elementar (n=1), os espécimes (2 mm de espessura e 6 mm de diâmetro) foram avaliados por espectroscopia de energia dispersiva de raios-x (EDS). As resistências de união dos grupos foram avaliadas pelo ensaio de microcisalhamento (n=20) em um substrato cerâmico de vidro reforçado com leucita, seguida da análise de modo de falha por microscopia eletrônica de varredura (MEV). Os valores médios, com exceção da avaliação química e do modo de falha, foram avaliados por ANOVA e pelo teste de Tukey. A estabilidade de cor foi influenciada pelo tempo de armazenagem (p<0,001) e interação entre a contaminação e o tempo (p<0,001). A contaminação pelo Hemostop e Viscostat Clear não influenciaram no GC, porém a contaminação com Viscostat aumentou o GC. A resistência de união do cimento a cerâmica foi negativamente afetada pelos contaminantes (p<0,001). A contaminação por agentes hemostáticos afetou a resistência de união, o grau de conversão e a estabilidade de cor do cimento resinoso fotoativado testado.


Subject(s)
Hemostatics , Resin Cements/chemistry , Color , Microscopy, Electron, Scanning , Solutions , Spectrum Analysis , Surface Properties
11.
Int. j. odontostomatol. (Print) ; 11(2): 173-177, June 2017. ilus
Article in English | LILACS | ID: biblio-893247

ABSTRACT

The aim of this study was to evaluate the extraction of dental DNA exposed to different chemical solutions. The sample was composed by 15 subjects, from which 5 samples of oral mucosal cells (reference population) and 15 teeth (experimental population) were collected. The experimental population was divided in three equal parts, which were exposed to different chemical solutions, namely hydrochloric acid (HCl) at 37 %, formaldehyde (CH2O) at 10 % and sodium hypochlorite (NaOCl) at 2.5 %. The DNA from the oral mucosa was extracted using organic method, while the dental DNA was extracted using the AFDIL method, including amplification by PCR and sequencing through capillary electrophoresis. The DNA exposed to hydrochloric acid dissolved, lacking extraction. The exposure of teeth to formaldehyde and sodium hypochlorite did not interfere in the extraction of DNA, once the amplification was visible in both experimental populations. The present outcomes demonstrated that DNA extraction may be limited under exposure to chemical solutions.


El objetivo de este estudio fue evaluar la extracción de ADN dental expuesto a diferentes soluciones químicas. La muestra estuvo compuesta por 15 sujetos, de los cuales se recogieron 5 muestras de células de la mucosa oral (población de referencia) y 15 dientes (población experimental). La población experimental se dividió en tres partes iguales, que fueron expuestas a diferentes soluciones químicas, a saber, ácido clorhídrico (HCl) al 37 %, formaldehído (CH2O) al 10 % e hipoclorito de sodio (NaOCl) al 2,5 %. El ADN de la mucosa oral se extrajo utilizando el método orgánico, mientras que el ADN dental se extrajo utilizando el método AFDIL, incluyendo la amplificación por PCR y la secuenciación a través de electroforesis capilar. El ADN expuesto al ácido clorhídrico se disolvió, careciendo de extracción. La exposición de los dientes al formaldehído e hipoclorito de sodio no interfirió en la extracción de ADN, una vez que la amplificación era visible en ambas poblaciones experimentales. Los resultados actuales demostraron que la extracción de ADN puede ser limitada bajo la exposición a soluciones químicas.


Subject(s)
Humans , DNA Fingerprinting/methods , Forensic Dentistry/methods , Solutions , Tooth , DNA/analysis , Forensic Genetics
12.
Rev. odontol. Univ. Cid. São Paulo (Online) ; 29(3): [237-242], set-dez. 2017. figuras
Article in Portuguese | LILACS, BBO | ID: biblio-908721

ABSTRACT

Objetivo: Determinar o pH crítico para ocorrer a corrosão de arcos NiTi em soluções de flúor a 1,1%, variando o pH de 3,5 a 7,0. Materiais e Métodos: Doze amostras com 10mm de comprimento de fio superelástico NiTi 0017 x 0025 (Abzil), obtidas do segmento distal dos arcos. As amostras foram aleatoriamente separadas e imersas dentro de recipientes contendo 40ml de seis soluções (água, soluções fluoretadas com pH: 3,5; 4,0; 4,5; 5,0; 5,5; 6,0; 6,5 e 7,0), sob uma mesa agitadora durante 90 minutos. Todas as amostras foram, então, levadas ao MEV. As imagens das amostras imersas em água e soluções fluoretadas com pH 7,0, 6,5 e 6,0 não se apresentaram diferentes, no entanto a partir da solução fluoretada com pH 5,5, as imagens superficiais apresentaram características diferentes dos grupos anteriores. Conclusão: Com base nos resultados obtidos neste estudo, o pH crítico para corrosão de arcos NiTi em soluções de flúor a 1,1% parece estar entre 6,0 e 5,5


Objective: To determine the critical pH to occur corrosion of NiTi arches in 1.1% fluoride solutions by varying the pH between 3.5 and 7.0. Materials and Methods: Twelve samples of 10 mm length superelastic NiTi wire 0017 x 0025 (Abzil) obtained in the distal segment of the arcs. The samples were randomly separated and immersed in 40 ml of six solutions (water, fluoride solutions with pH: 3.5; 4.0; 4.5; 5.0; 5.5; 6.0; 6.5 and 7.0) under a shaker table for 90 minutes. All samples were observed under SEM. The images of the samples immersed in water and fluoride solutions at pH 7.0, 6.5 and 6.0 did not show differences, however from the fluoride solution at pH 5.5, the surface characteristics of images presented differences from above groups. Conclusion: Based on the results obtained in this study the critical pH for corrosion of NiTi arches in fluoride solutions to 1.1% appears to be between 6.0 and 5.5


Subject(s)
Corrosion , Fluorine , Solutions
13.
Braz. oral res. (Online) ; 31: e76, 2017. graf
Article in English | LILACS | ID: biblio-952131

ABSTRACT

Abstract To evaluate the influence of rewetting solutions on bond strength to root dentin of conventional gutta-percha (GP) or niobium phosphate glass-based gutta-percha (GNb) associated with a bioceramic sealer. The root canals of 80 human mandibular premolars were prepared using nickel-titanium instruments and irrigation with sodium hypochlorite and EDTA. The teeth were randomly divided into four groups according to the gutta-percha used: GNb or GP associated with EndoSequence BC Sealer (BC) and the solution for rewetting dentin before filling (distilled water; phosphate buffer saline solution - PBS; simulated body fluid - SBF; or no solution). The root canals were filled with a single cone using warm vertical condensation. Micropush-out bond strengths associated with the filling materials in slices from middle root thirds was determined 30 days after root filling. The failure mode was analyzed with stereoscopic lens. The data were statistically analyzed by two-way ANOVA and Holm-Sidak test (p < 0.05). There was significant difference in the types of gutta-percha (p < 0.001) and in the different rewetting solutions (p = 0.003). The interaction between gutta-percha and rewetting solutions was not significant (p = 0.53). The SBF solution provided an increase in bond strength for both gutta-percha solutions. The GNb+BC (3.42 MPa) association increased bond strength when compared with GP+BC (2.0 MPa). The use of SBF as a dentin rewetting solution increased bond strength in the groups studied. Association of GNb with bioceramic sealer was beneficial, increasing the bond strength to dentin when compared with the association with GP.


Subject(s)
Humans , Solutions/chemistry , Ceramics/chemistry , Dental Bonding/methods , Dentin/drug effects , Gutta-Percha/chemistry , Reference Values , Surface Properties/drug effects , Biocompatible Materials/chemistry , Materials Testing , Reproducibility of Results , Analysis of Variance , Statistics, Nonparametric , Root Canal Preparation/methods , Dental Restoration Failure , Dentin/chemistry , Niobium/chemistry
14.
Rev. paul. pediatr ; 34(4): 403-407, Oct.-Dec. 2016. tab
Article in English | LILACS | ID: biblio-830745

ABSTRACT

Abstract Objective: Study the use of magistral oral solutions and suspensions in infants and children at a university hospital. Methods: This is a descriptive study based on the analysis of the assessed hospital's magistral drug request forms regarding the patients in the neonatal ICU, Obstetrics, Pediatrics and Pediatric Emergency from January 2012 to December 2013. The frequency of drug requests and dispensation was evaluated and the consumption of each active ingredient of the preparations was expressed as number of “infant defined daily dose” (iDDD) and of iDDD/100 bed-days. Results: A total of 657 forms were analyzed - a monthly average of 27 pediatric preparations. The neonatal ICU accounted for 69.6% of these requests. Twenty-one drug items were used, of which the most common were folinic acid (88 requests), sulfadiazine (85) and captopril (73). The consumption of the active principle in these preparations varied in number of iDDD, from 7.5 (hydralazine) to 16,520.0 (folic acid), and in number of iDDD/100 bed-days in the neonatal ICU, from 0.1 (zinc sulfate) to 146.1 (folic acid). Conclusions: The constant consumption of magistral oral solutions and suspensions by newborns and children of the assessed hospital indicates the need for such preparations as a pediatric therapeutic alternative in this hospital.


Resumo Objetivo: Estudar o uso de soluções e suspensões orais magistrais em recém-nascidos e crianças de um hospital universitário. Métodos: Foi feito um estudo descritivo a partir da análise dos formulários de solicitação de manipulação do hospital estudado referentes aos pacientes da UTI-neonatal, obstetrícia, pediatria e emergência pediátrica de janeiro de 2012 a dezembro de 2013. As frequências das solicitações e dispensações desses medicamentos foram avaliadas e o consumo de cada princípio ativo das preparações foram expressos sob a forma de número de infant defined daily dose (iDDD) e de iDDD/100 leitos-dia. Resultados: Foram analisados 657 formulários - média mensal de 27 preparações pediátricas. A UTI-neonatal foi responsável por 69,6% dessas solicitações. Foram usados 21 itens de medicamentos, destacou-se o uso de ácido folínico (88 solicitações), sulfadiazina (85) e captopril (73). O consumo de princípio-ativo nessas preparações variou, em número de iDDD, de 7,5 (hidralazina) a 16.520 (ácido fólico) e em número de iDDD/100 leitos-dia da UTI-neonatal, de 0,1 (sulfato de zinco) a 146,1 (ácido fólico). Conclusões: O consumo constante das soluções e suspensões orais magistrais pelos recém-nascidos e crianças do hospital estudado indica a necessidade dessas preparações como opção terapêutica pediátrica nesse hospital.


Subject(s)
Humans , Male , Infant, Newborn , Prescription Drugs/therapeutic use , Solutions/therapeutic use , Suspensions/therapeutic use , Intensive Care Units, Neonatal , Administration, Oral , Retrospective Studies , Drug Compounding , Hospitalization , Hospitals, University
15.
Article in English | WPRIM | ID: wpr-310908

ABSTRACT

<p><b>OBJECTIVE</b>To examine the relaxant effects of hydro-ethanolic, macerated aqueous (MA) and lipidfree macerated aqueous (LFMA) extract of Tymus vulgaris on tracheal chains of guinea pigs.</p><p><b>METHODS</b>The relaxant effects of five cumulative concentrations of each extract (0.4, 0.8, 1.2, 1.6 and 2.0 g/100 mL) were compared with saline as negative control and five cumulative concentrations of theophylline (0.1, 0.2, 0.4, 0.6 and 0.8 mmol/L) on precontracted tracheal smooth muscle of guinea pig with 60 mmol/L KCl (group 1) and 10 µmol/L methacholine (group 2, n=6 for each group).</p><p><b>RESULTS</b>In group 1 all concentrations of theophylline, three higher concentrations of hydro-ethanolic, two concentrations of LFMA and last concentration of MA extracts showed significant relaxant effects compared with that of saline (P<0.05 or P<0.01). Two lower concentrations of LFMA and all concentrations of MA except higher one caused contraction compared with saline (P<0.05 or 0.01). In group 2 experiments, all concentrations of theophylline, hydro-ethanolic, MA and LFMA extracts showed significant relaxant effects compared to that of saline (P<0.05 or P<0.01). In both groups, the relaxant effect of all concentrations of hydro-ethanolic extract were significantly higher than most concentrations of others (P<0.05 or P<0.01). The relaxant effect of different concentrations of three extracts were significantly greater in group 2 compared with group 1 experiments (all P<0.01). There were significantly positive correlations between the relaxant effects and concentrations for theophylline and all extracts in both groups (P<0.05 or P<0.01).</p><p><b>CONCLUSION</b>Hydro-ethanolic extract has a potent weaker relaxant effect for other extracts from Tymus vulgaris on tracheal chains of guinea pigs.</p>


Subject(s)
Animals , Bronchodilator Agents , Pharmacology , Guinea Pigs , In Vitro Techniques , Lamiaceae , Chemistry , Lipids , Chemistry , Muscle Relaxation , Muscle, Smooth , Physiology , Plant Extracts , Pharmacology , Solubility , Solutions , Theophylline , Trachea , Physiology , Water , Chemistry
16.
Article in Chinese | WPRIM | ID: wpr-263972

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of particle size and morphology on zinc cation adsorption by hydroxyapatite (HA) and dentifrice containing HA.</p><p><b>METHODS</b>Four HAs with different particle sizes and morphologies, HA-containing dentifrice and blank dentifrice were prepared into suspensions of serial concentrations. Zinc ion solutions with an initial concentration of 10 mg/L was mixed with the suspensions and kept for 24 h for adsorption reaction. The zinc ion concentration in the supernatant was measured by inductively coupled plasma emission spectrometer and the sorption rate of zinc ion was calculated.</p><p><b>RESULTS</b>HA and HA-containing dentifrice with various particle sizes and morphologies were all capable of absorbing zinc ions from simulated waste water, and the adsorption rate of HA-containing dentifrice was 3%-10% higher than that of HA. HA with a particle size of 12 µm and a spherical morphology showed the strongest adsorption ability, followed by short bar-shaped HA with a particle size of 30 µm. Both Langmuir and Freundlich equation could simulate the sorption processes of HA dentifrice, while only Langmuir equation could simulate the sorption processes of HA.</p><p><b>CONCLUSION</b>Incorporation of HA in dentifrice can enhance zinc ion adsorption capacity of the material. The particle size and morphology of HA both affect the adsorption of zinc ions, and 12-µm HA particle with a spherical morphology has the best adsorption ability.</p>


Subject(s)
Adsorption , Dentifrices , Chemistry , Durapatite , Chemistry , Particle Size , Solutions , Zinc , Chemistry
17.
Article in Chinese | WPRIM | ID: wpr-261195

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months.</p><p><b>METHODS</b>Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3.</p><p><b>RESULTS</b>A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD=-21.16, 95%CI -39.66 to -2.77, P<0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD=-13.83, 95%CI -20.88 to -6.78, P<0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Co</p><p><b>ONCLUSIONS</b>Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.</p>


Subject(s)
Crying , Humans , Infant , Pain , Solutions , Sucrose , Vaccination
18.
ABCD arq. bras. cir. dig ; 28(4): 262-265, Nov.-Dec. 2015. tab, graf
Article in Portuguese | LILACS | ID: lil-770252

ABSTRACT

Background: Endoscopic submucosal dissection carries an increased risk of bleeding and perforation. The creation of a long lasting submucosal cushion is essential for the safe and complete removal of the lesion. There is not a suitable experimental model for evaluation of the durability of the cushioning effect of different solutions. Aim: To describe an improved experimental model to evaluate submucosal injection solutions. Methods: A total of four domestic pigs were employed to evaluate two different submucosal fluid solutions in the gastric submucosa. After midline laparotomy, the anterior gastric wall was incised from the gastric body to the antrum and its mucosal surface was exposed by flipping inside out the incised gastric wall. Two different solutions (10% mannitol and normal saline) were injected in the submucosa of the anterior wall of the distal gastric body. All submucosal cushions were injected until they reach the same size, standardized as 1.0 cm in height and 2.0 cm in diameter. A caliper and a ruler were employed to guarantee accuracy of the measurements. Results: All four animal experiments were completed. All submucosal cushions had the exact same size measured with caliper and a ruler. By using the mannitol solution, the mean duration of the submucosal cushion was longer than the saline solution: 20 and 22 min (mean, 21 min) vs 5 and 6 min (mean, 5.5 min) Conclusions: This experimental model is simple and evaluate the duration, size, and effect of the submucosal cushion, making it more reliable than other models that employ resected porcine stomachs or endoscopic images in live porcine models.


Racional: Sabe-se que os maiores riscos na ressecção endoscópica da submucosa são o sangramento e a perfuração. A criação de um coxim submucoso duradouro é essencial para a remoção da lesão completa e com segurança. Atualmente não se conhece um modelo experimental adequado para avaliação da durabilidade do coxim submucoso com diferentes soluções. Objetivo : Descrever um modelo experimental melhorado para avaliar soluções de injeção de submucosa. Métodos: Foram utilizados quatro porcos domésticos para avaliar dois tipos diferentes de soluções para injeção na submucosa gástrica. Após laparotomia mediana, a parede gástrica anterior foi aberta no sentido corpo-antro e sua superfície mucosa foi exposta por eversão da abertura gástrica. Dois tipos diferentes de solução (manitol a 10% e solução salina normal) foram injetados na submucosa da parede gástrica anterior de corpo distal. Todos os coxins submucosos foram injetados até que alcançassem o mesmo tamanho, padronizado como 1,0 cm de altura por 2,0 cm de diâmetro. Foram aplicados régua e compasso para garantir a acurácia das medidas. Resultados: O experimento foi completo nos quatro animais. Todos os coxins submucosos tinham o mesmo tamanho, medido com régua e compasso. Com o uso da solução de manitol, a duração média do coxim submucoso foi maior que a da solução salina: 20 e 22 min (média 21 min) vs 5 e 6 min (média 5,5 min). Conclusões: Este modelo experimental é simples e permite analisar duração, tamanho e efeito do coxim submucoso, tornando-se mais confiável que outros modelos que empregam estômagos ressecados de porcos ou imagens endoscópicas de modelos porcinos vivos.


Subject(s)
Animals , Dissection/methods , Gastroscopy , Gastric Mucosa/surgery , Solutions/administration & dosage , Evaluation Studies as Topic , Injections , Models, Animal , Swine
19.
Rev. bras. anestesiol ; 65(3): 207-212, May-Jun/2015. tab, graf
Article in English | LILACS | ID: lil-748922

ABSTRACT

BACKGROUND AND OBJECTIVE: Postoperative pain treatment in mastectomy remains a major challenge despite the multimodal approach. The aim of this study was to investigate the analgesic effect of intravenous lidocaine in patients undergoing mastectomy, as well as the postoperative consumption of opioids. METHODS: After approval by the Human Research Ethics Committee of the Instituto de Medicina Integral Prof. Fernando Figueira in Recife, Pernambuco, a randomized, blind, controlled trial was conducted with intravenous lidocaine at a dose of 3 mg/kg infused over 1 h in 45 women undergoing mastectomy under general anesthesia. One patient from placebo group was. RESULTS: Groups were similar in age, body mass index, type of surgery, and postoperative need for opioids. Two of 22 patients in lidocaine group and three of 22 patients in placebo group requested opioid (p = 0.50). Pain on awakening was identified in 4/22 of lidocaine group and 5/22 of placebo group (p = 0.50); in the post-anesthetic recovery room in 14/22 and 12/22 (p = 0.37) of lidocaine and placebo groups, respectively. Pain evaluation 24 h after surgery showed that 2/22 and 3/22 patients (p = 0.50) of lidocaine and placebo groups, respectively, complained of pain. CONCLUSION: Intravenous lidocaine at a dose of 3 mg/kg administered over a period of an hour during mastectomy did not promote additional analgesia compared to placebo in the first 24 h, and has not decreased opioid consumption. However, a beneficial effect of intravenous lidocaine in selected and/or other therapeutic regimens patients cannot be ruled out. .


JUSTIFICATIVA E OBJETIVO: O tratamento da dor pós-operatória em mastectomia continua sendo um grande desafio apesar da abordagem multimodal. O objetivo deste estudo foi investigar o efeito analgésico da lidocaína intravenosa em pacientes submetidas a mastectomia, como também, o consumo de opioide pós-operatório. MÉTODOS: Após aprovação pelo comitê de ética e pesquisa em seres humanos do Instituto de Medicina Integral Prof. Fernando Figueira em Recife - Pernambuco foi realizado ensaio clínico aleatório encoberto placebo controlado com lidocaína intravenosa na dose de 3 mg/kg infundida em uma hora, em 45 mulheres submetidas a mastectomia sob anestesia geral. Excluída uma paciente do grupo placebo. RESULTADOS: Os grupos foram semelhantes quanto à idade, índice de massa corpórea, tipo de intervenção cirúrgica e necessidade de opioide no pós-operatório. Solicitaram opioide 2/22 pacientes nos grupos da lidocaína e 3/22 placebo (p = 0,50). Identificada a dor ao despertar em 4/22 no grupo lidocaína e 5/22 (p = 0,50) no grupo placebo; na sala de recuperação pós-anestésica em 14/22 e 12/22 (p = 0,37) nos grupos lidocaína e placebo respectivamente. Ao avaliar a dor 24 horas após o procedimento cirúrgico 3/22 e 2/22 (p = 0,50) das pacientes relataram dor em ambos os grupos respectivamente. CONCLUSÃO: A lidocaína intravenosa na dose de 3mg/kg administrada em um período de uma hora no transoperatório de mastectomia não promoveu analgesia adicional em relação ao grupo placebo nas primeiras 24 horas e não diminuiu o consumo de opioide. Contudo, um efeito benéfico da lidocaína intravenosa em pacientes selecionadas e/ou em outros regimes terapêuticos não pode ser descartado. .


JUSTIFICACIÓN Y OBJETIVO: El tratamiento del dolor postoperatorio en la mastectomía continúa siendo un gran reto a pesar del abordaje multimodal. El objetivo de este estudio fue investigar el efecto analgésico de la lidocaína intravenosa en pacientes sometidas a mastectomía, así como el consumo postoperatorio de opiáceos. MÉTODOS: Después de la aprobación por el Comité de Ética e Investigación en seres humanos del Instituto de Medicina Integral Prof. Fernando Figueira, en Recife, Pernambuco, se realizó un ensayo clínico aleatorizado, encubierto, placebo controlado con lidocaína intravenosa en una dosis de 3 mg/kg infundida en una hora, en 45 mujeres sometidas a mastectomía bajo anestesia general. Una paciente del grupo placebo fue excluida. RESULTADOS: Los grupos fueron similares en cuanto a la edad, índice de masa corporal, tipo de intervención quirúrgica y necesidad de opiáceos en el postoperatorio. Solicitaron opiáceos 2/22 pacientes en los grupos de la lidocaína y 3/22 placebo (p = 0,50). Fue identificado el dolor al despertar en 4/22 en el grupo lidocaína y 5/22 (p = 0,50) en el grupo placebo; en la sala de recuperación postanestésica en 14/22 y 12/22 (p = 0,37) en los grupos lidocaína y placebo, respectivamente. Al calcular el dolor 24 h después del procedimiento quirúrgico 3/22 y 2/22 (p = 0,50) de las pacientes relataron dolor en ambos grupos respectivamente. CONCLUSIÓN: La lidocaína intravenosa en una dosis de 3 mg/kg administrada en un período de una hora en el transoperatorio de mastectomía no generó analgesia adicional con relación al grupo placebo en las primeras 24 h y no disminuyó el consumo de opiáceos. Sin embargo, no puede ser descartado un efecto beneficioso de la lidocaína intravenosa en pacientes seleccionadas y/o en otros regímenes terapéuticos. .


Subject(s)
Humans , Metapneumovirus/genetics , Transcription, Genetic , Viral Proteins/chemistry , Amino Acid Sequence , Adenosine Monophosphate/metabolism , Crystallography, X-Ray , DNA , Edetic Acid/pharmacology , Molecular Dynamics Simulation , Molecular Sequence Data , Protein Binding , Protein Conformation , Protein Multimerization , Protein Stability , Protein Subunits/chemistry , RNA, Viral/metabolism , RNA, Viral/ultrastructure , Scattering, Small Angle , Solutions , Solvents , Viral Proteins/metabolism , Viral Proteins/ultrastructure , Zinc Fingers
20.
Braz. dent. j ; 26(1): 66-68, Jan-Feb/2015. tab
Article in English | LILACS | ID: lil-735832

ABSTRACT

The purpose of this study was to evaluate the effect of an alcohol-based caries detector (Kurakay) on the surface tension of a conventional sodium hypochlorite (NaOCl) preparation, and a product containing a surface-active agent (Chlor-XTRA). The surface tensions of the following solutions were tested: NaOCl, a mixture of NaOCl and Kurakay 9:1 w/w, Chlor-XTRA, a mixture of Chlor-XTRA and Kurakay 9:1 w/w. Ten measurements per test solution were made at 20 C, using an optical method called the "Pendant drop method", with a commercially available apparatus. The addition of Kurakay reduced the surface tension for NaOCl (p<0.05) whilst no significant difference was detected for Chlor-XTRA (p>0.05). Statistically significant differences between the NaOCl and Chlor-XTRA groups were found (p<0.05). The addition of an alcohol-based caries detector resulted in a reduction of the original surface tension values for NaOCl only. Taking into account the fact that mixtures of NaOCl and Kurakay have been used to assess the penetration of root canal irrigants in vitro, the related changes in surface tension are a possible source of bias.


O objetivo deste estudo foi avaliar o efeito de um detector de cárie com álcool (Kurakay) sobre a tensão superficial de um preparado convencional de hipoclorito de sódio (NaOCl) e um produto contendo um agente surfactante (Chlor-XTRA). Foram testadas as tensões superficiais das seguintes soluções: NaOCl, uma mistura de NaOCl e Kurakay na proporção de 9:1 em peso, Chlor-XTRA e um mistura de Chlor-XTRA e Kurakay na proporção de 9:1 em peso. Dez medidas foram feitas com cada solução, a 20 °C, utilizando um método óptico chamado "Método da gota pendente" (Pendant drop method) usando aparelhos disponíveis. Adição do Kurakay reduziu a tensão superficial do NaOCl (p<0,05), mas não houve diferença significante para Chlor-XTRA (p>0,05). Foram encontradas diferenças estatisticamente significantes entre os grupos NaOCl e Chlor-XTRA (p<0,05). Adição de um detector de cárie com álcool resultou na diminuição do valor original da tensão superficial apenas para NaOCl. Considerando que as misturas de NaOCl e Kurakay tem sido usadas para estudar a penetração in vitro dos irrigantes radiculares, as diferenças acima são uma possível fonte de desvio nos resultados.


Subject(s)
Ethanol/chemistry , Propylene Glycols/chemistry , Rhodamines/chemistry , Root Canal Irrigants/chemistry , Sodium Hypochlorite/chemistry , Surface-Active Agents/chemistry , Solutions , Surface Tension
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