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1.
Coluna/Columna ; 19(1): 48-51, Jan.-Mar. 2020. tab
Article in English | LILACS (Americas) | ID: biblio-1089636

ABSTRACT

ABSTRACT Objective This paper proposes a retrospective analysis of the spinal cord trauma at a regional hospital that is a Unified Health System (SUS) reference in Orthopedics and Traumatology, considering epidemiological data and comparing treatments and hospitalization costs. Methods This study is a retrospective, analytical-descriptive, exploratory documental analysis, using data from the medical records of patients treated for spinal cord trauma during 2016 at the São José Municipal Hospital (Joinville, SC). Results Twenty-three patients were included in the study, 20 of whom (87%) were male. As to etiology, traffic accidents accounted for 47.8% of the cases and gunshot wounds were in second place with 26.1% of the injuries. The correlation between the cost of hospitalization and the days of hospitalization was statistically significant (p = 0.013), as was the correlation between the cost of hospitalization and the number of procedures (p = 0.000). Conclusions Surgical treatment demands greater amounts of financial and human resources. The purpose of this study is to provide local epidemiological data to encourage discussion about other studies, as well as planning for resource allocation and public policy. Level of evidence II; Retrospective Study.


RESUMO Objetivo O presente estudo propõe uma análise retrospectiva relacionada ao traumatismo raquimedular de um hospital de referência regional em Ortopedia e Traumatologia pelo Sistema Único de Saúde (SUS), considerando dados epidemiológicos, comparações entre tratamentos e custos das internações. Métodos Trata-se de um estudo retrospectivo, analítico-descritivo de análise exploratória documental, utilizando dados de prontuários médicos de pacientes atendidos com traumatismo raquimedular durante o ano de 2016 no Hospital Municipal São José (Joinville - SC). Resultados Foram incluídos no estudo 23 pacientes, sendo 20 (87%) do sexo masculino. Quanto à etiologia, os acidentes de trânsito foram responsáveis por 47,8% dos casos e os ferimentos por arma de fogo ocuparam o segundo lugar com 26,1% dos agravos. A correlação entre o custo da internação e os dias da internação foi estatisticamente significativa (p=0,013), assim como a correlação entre o custo da internação e o número de procedimentos (p=0,000). Conclusões O tratamento cirúrgico demanda maior quantidade de recursos financeiros e humanos. O propósito do presente trabalho consiste em fornecer os dados epidemiológicos locais para fomentar a discussão de outros trabalhos, assim como o planejamento para alocação de recursos e de políticas públicas. Nível de evidência II; Estudo Retrospectivo.


RESUMEN Objetivo El presente estudio propone un análisis retrospectivo relacionado al traumatismo raquimedular de un hospital de referencia regional en Ortopedia y Traumatología por el Sistema Único de Salud (SUS), considerando datos epidemiológicos, comparaciones entre tratamientos y costos de las internaciones. Métodos Se trata de un estudio retrospectivo, analítico-descriptivo de análisis exploratorio documental, utilizando datos de prontuarios médicos de pacientes atendidos con traumatismo raquimedular durante el año 2016 en el Hospital Municipal São José (Joinville - SC). Resultados Fueron incluidos en el estudio 23 pacientes, siendo 20 (87%) del sexo masculino. Cuanto a la etiología, los accidentes de tránsito fueron responsables por 47,8% de los casos y las heridas por arma de fuego ocuparon el segundo lugar, con 26,1% de los agravios. La correlación entre el costo de la internación y los días de internación fue estadísticamente significativa (p=0,013), así como la correlación entre el costo de internación y el número de procedimientos (p=0,000). Conclusiones El tratamiento quirúrgico demanda mayor cantidad de recursos financieros y humanos. El propósito del presente trabajo consiste en suministrar los datos epidemiológicos locales para fomentar la discusión de otros trabajos, así como la planificación para la asignación de recursos y de políticas públicas. Nivel de evidencia II; Estudio Retrospectivo.


Subject(s)
Humans , Public Policy , Spinal Cord Injuries , Unified Health System
2.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-781779

ABSTRACT

OBJECTIVE@#To compare the clinical effect on intestinal dysfunction of spinal cord injury (SCI) between the comprehensive therapy of moxibustion (moxibustion for opening the governor vessel and regulating the spirit) and rehabilitation training and the simple treatment with rehabilitation training.@*METHODS@#A total of 60 patients with intestinal dysfunction of SCI were randomized into a comprehensive therapy group and a rehabilitation group, 30 cases in each one (3 cases were dropped out in each group). On the base of the routine western medicine treatment and rehabilitation training, the bowel training and rectal function training were provided, once a day in the rehabilitation group. In the comprehensive therapy group, on the base of the treatment as the rehabilitation group, the moxibustion was exerted at Yaoyangguan (GV 3), Mingmen (GV 4), Zhiyang (GV 9), Dazhui (GV 14) and Baihui (GV 20), etc, once a day, 30 min each time. In both groups, the treatment for 4 weeks was as one course and 3 courses of treatment were required. Separately, before treatment, after 4, 8 and 12 weeks of treatment, the scores of neurogenic bowel dysfunction (NBD) and World Health Organization quality of life scale (WHOQOL-BREF) were observed and the clinical effect was evaluated after 12 weeks of treatment.@*RESULTS@#After treatment, the total effective rate was 88.9% (24/27) in the comprehensive therapy group, which was higher than 74.1% (20/27) in the rehabilitation group (<0.05). After 4, 8 and 12 weeks of treatment, NBD scores were all reduced obviously as compared with those before treatment in the two groups (all <0.01). After 8 and 12 weeks of treatment, NBD scores in the comprehensive therapy group were lower than the rehabilitation group (both <0.05). After 4, 8 and 12 weeks of treatment, the scores of all of the domains (psychology, physiology, social relations and environment) in WHOQOL-BREF were higher than those before treatment in the two groups (all <0.01). After 4 weeks of treatment, the scores in the psychology and physiology domains in the comprehensive therapy group were higher than the rehabilitation group (all <0.05). After 8 and 12 weeks of treatment, the scores of all of the domains in the comprehensive therapy group were higher than the rehabilitation group (all <0.05).@*CONCLUSION@#The comprehensive treatment of moxibustion and rehabilitation training achieves the better effect on intestinal dysfunction of SCI than the simple rehabilitation training and greatly improves the quality of life in SCI patients.


Subject(s)
Acupuncture Points , Humans , Moxibustion , Quality of Life , Spinal Cord Injuries , Therapeutics
3.
Article in English | WPRIM (Western Pacific) | ID: wprim-785548

ABSTRACT

Robots are being used to assist the recovery of walking ability for patients with neurologic disorders. This study aimed to evaluate the feasibility and functional improvement of training with robot-assisted gait training (RAGT) using the Morning Walk®, an end-effector type robot using footplates and saddle seat support. A total of 189 individuals (65.1% men, 34.9% women; mean age, 53.2 years; age range: 5–87 years) with brain lesions, spinal cord injuries, Parkinson's disease, peripheral neuropathies, and pediatric patients were involved in this retrospectively registered clinical trial. Each participant performed 30 minutes of RAGT, five times a week, for a total of 24 sessions. Failure was defined as an inability to complete all 24 sessions, and the reasons for discontinuation were analyzed. Parameters of Medical Research Council scales and Functional Ambulation Categories were analyzed before and after RAGT training. Among the 189 patients, 22 (11.6%) failed to complete the RAGT. The reasons included decreased cooperation, musculoskeletal pain, saddle seat discomfort, excessive body-weight support, joint spasticity or restricted joint motion, urinary incontinence from an indwelling urinary catheter, and fatigue. Comparison between the pre- and post-training motor and ambulatory functions showed significant improvement. The result of the study indicates that the Morning Walk® is feasible and safe and useful for functional improvement in patients with various neurologic disordersTRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0003627


Subject(s)
Brain , Fatigue , Female , Gait , Humans , Information Services , Joints , Male , Muscle Spasticity , Musculoskeletal Pain , Nervous System Diseases , Parkinson Disease , Peripheral Nervous System Diseases , Retrospective Studies , Spinal Cord Injuries , Urinary Catheters , Urinary Incontinence , Walking , Weights and Measures
4.
ABCS health sci ; 44(3): 161-166, 20 dez 2019. tab
Article in English, Portuguese | LILACS (Americas) | ID: biblio-1047658

ABSTRACT

INTRODUÇÃO: A lesão medular acarreta em perda da independência funcional, autonomia e status social. Essa enorme mudança contribui para o aparecimento dos sintomas depressivos nessa população. OBJETIVO: Avaliar os sintomas depressivos e disfunção sexual em homens com lesão medular traumática, analisando a associação entre eles. MÉTODOS: Estudo observacional, realizado com 44 homens com lesão medular traumática, idade entre 18 e 60 anos, tempo de lesão superior a um ano e vida sexual ativa. O grau de comprometimento neurológico foi avaliado através da versão revisada em 2011 da ASIA Impairment Scale, os sintomas depressivos através do Inventário de Depressão de Beck e a função sexual através do Índice Internacional de Função Erétil. Foram aplicadas técnicas de estatística descritiva e análise bivariada para verificar associação, utilizando um nível de significância de 0,05. RESULTADOS: Os voluntários possuíam média de idade de 34,1 anos, e tempo médio de lesão de 7,7 anos. Todos os indivíduos da amostra tinham nível de lesão acima do segmento medular L2, sendo as incompletas as mais frequentes (68,2%). O tempo médio da última relação sexual foi de 56,5 dias e a frequência semanal de relação sexual foi a mais relatada (65,9%). Da amostra, apenas 17,6% tinham sintomas depressivos, sendo 6,8% com disforia e 6,8% apresentando sintomas leves a moderados. Não foi encontrada associação entre sintomas depressivos e disfunção sexual, exceto para o domínio da disfunção de satisfação geral (p=0,02). CONCLUSÃO: Não existe associação entre sintomas depressivos e disfunção sexual em homens com lesão medular crônica.


INTRODUCTION: Spinal cord injury results in loss of functional independence, autonomy and social status. This enormous change contributes to the appearance of depressive symptoms in this population. OBJECTIVE: To evaluate depressive symptoms and sexual dysfunction in men with traumatic spinal cord injury, and to analyze their association. METHODS: Observational study was performed with 44 men with traumatic spinal cord injury, age between 18 and 60 years, injury time over 1 year and active sexual life. The degree of neurological impairment was assessed through the revised 2011 ASIA Impairment Scale, depressive symptoms through the Beck Depression Inventory, and sexual function through the International Erectile Function Index. Descriptive statistics techniques and bivariate analysis were applied to verify association, using a level of significance of 0.05. RESULTS: The volunteers had a mean age of 34.1 years, and an average injury time of 7.7 years. All individuals in the sample had lesion level above the medullary segment L2, with incomplete injury being the most frequent (68.2%). The mean time of the last sexual intercourse was 56.5 days and the weekly frequency of intercourse was the most reported (65.9%). Only 17.6% of the sample presented depressive symptoms, ranging from dysphoria (6.8%) to mild to moderate symptoms (6.8%). No association was found between depressive symptoms and sexual dysfunction, except for the domain of general satisfaction dysfunction (p=0.02). CONCLUSION: There is no association between depressive symptoms and sexual dysfunction in men with chronic spinal cord injury.


Subject(s)
Humans , Male , Adolescent , Adult , Middle Aged , Young Adult , Quality of Life , Spinal Cord Injuries , Sexuality , Depression , Erectile Dysfunction
5.
Licere (Online) ; 22(3): 579-602, set.2019. tab
Article in Portuguese | LILACS (Americas) | ID: biblio-1046739

ABSTRACT

Intervenções com a Realidade Virtual (RV) tem sido descritas como alternativas para o tratamento de pessoas com lesão da medula espinal (LME). O presente estudo buscou oferecer uma visão geral das intervenções que utilizaram a RV na reabilitação e como estratégia de lazer destes indivíduos. Foi realizada uma revisão sistemática, nas bases de dados PubMed (Medline), Biblioteca Virtual em Saúde (BVS), Scielo e Lilacs nos últimos cinco anos. Um total de 13 artigos foram identificados. A RV foi utilizada para diversos objetivos como: verificar a melhora da função dos membros superiores; associar com estímulos sensoriais durante a marcha; identificar os efeitos da caminhada virtual sobre o grau de dor. Assim, percebe-se que a RV pode ser usada para diversas finalidades, além de fornecer um meio mais envolvente de tratamento para pessoas com LME, adicionando uma dimensão de prazer e um momento para o lazer.


Interventions with Virtual Reality (VR) have been described as alternatives for the treatment of people with spinal cord injury (LME). The present study sought to provide an overview of the interventions that used VR in the rehabilitation of these individuals. A systematic review was performed in the PubMed (Medline), Virtual Health Library (VHL), Scielo and Lilacs databases in the last 5 years. A total of 13 articles have been identified. VR was used for several purposes such as: to verify the improvement of upper limb function; associated with sensory stimuli during gait; to identify the effects of virtual walking on the degree of pain. Thus, it can be seen that RV can be used for different purposes, as well as providing a more involving means of treatment for people with LME, adding a dimension of pleasure and a moment for leisure.


Subject(s)
Humans , Adult , Psychomotor Performance , Quality of Life , Rehabilitation , Socialization , Spinal Cord Injuries , Chronic Pain/therapy , Pain Management , Virtual Reality , Health Promotion , Leisure Activities
6.
Av. enferm ; 37(1): 19-26, ene.-abr. 2019. tab
Article in Portuguese | LILACS (Americas), BDENF, COLNAL | ID: biblio-1011384

ABSTRACT

Resumo Objetivo: O objetivo do estudo é realizar levantamento de dados clínicos e epidemiológicos dos pacientes com feridas em uma unidade do sistema prisional no estado de São Paulo. Metodologia: Estudo retrospectivo e descritivo onde foram coletados dados dos prontuários de uma unidade prisional anotados em livros de registros e prontuários de saúde entre janeiro de 2015 e janeiro de 2016. Resultados: Foram analisados 52 prontuários de pacientes com feridas. Todos os pacientes eram do sexo masculino, sendo 51,92 % brancos e 53,85 % possuíam entre 30-39 anos. Foram encontradas lesões de 10 etiologias diferentes, sendo as queimaduras as mais frequentes (22,95 %), seguidas de lesões por pressão (21,31 %). A doença mais constante nos pacientes em tratamento de feridas foi lesão medular. Conclusão: Os pacientes com feridas no sistema prisional eram em sua maior parte brancos, do sexo masculino, com idade média de 37,21 anos, sendo mais frequentes as queimaduras e as lesões por pressão.


Resumen Objetivo: Realizar el levantamiento de los datos clínicos y epidemiológicos de los pacientes con heridas en una unidad del sistema penitenciario en el estado de São Paulo. Metodología: Estudio retrospec-tivo-descriptivo donde se recolectan datos de los prontuarios de una unidad penitenciaria registrados en libro-acta y prontuarios de salud entre enero de 2015 y enero de 2016. Resultados: Fueron analizados 52 prontuarios de pacientes con heridas. Todos los pacientes fueron del sexo masculino, 51,92 % blancos, 53,85 % tenían entre 30-39 años. Se encontraron lesiones de 10 etiologías diferentes, siendo las quemaduras las más frecuentes 22,95 %, seguidas de lesiones por presión 21,31 %. La enfermedad más común de los pacientes en tratamiento de heridas fue lesión medular. Conclusión: Los pacientes con heridas en el sistema penitenciario eran en su mayor parte blancos, todos del sexo masculino, con una edad media de 37,21 años, siendo más frecuentes las quemaduras y las lesiones por presión.


Abstract Objective: To perform the lifting of the epidemiological and clinical data of patients with wounds in a unit of the prison system in the State of São Paulo. Methodology: Retrospective and descriptive study where there are collected data of compendium of a prison unit registered in a record book and health compendium between January 2015 and January 2016. Results: 52 compendia of patients with wounds were analyzed. All patients were male, 51.92 % white, 53.85 % were between 30 and 39 years old. Injuries of 10 different etiologies were found, being burns the most frequent (22.95 %), followed by lesions by pressure (21.31 %). The most common disease among patients in treatment of wounds was spinal cord injury. Conclusion: In the prison system, patients with wounds are predominantly white, all male, with an average age of 37.21 years old, being more frequent burns and injuries by pressure.


Subject(s)
Humans , Male , Adult , Prisons , Wounds and Injuries , Pressure , Spinal Cord Injuries , Burns , Male
7.
Acta fisiátrica ; 26(1)mar. 2019.
Article in English, Portuguese | LILACS (Americas) | ID: biblio-1046642

ABSTRACT

Objetivo: Descrever o processo de desenvolvimento e validação do instrumento baseado no Core Set resumido da Classificação Internacional da Funcionalidade, Incapacidade e Saúde para indivíduos com lesão medular aguda. Método: No estudo metodológico foi desenvolvido um instrumento para avaliação da funcionalidade de indivíduos com lesão medular aguda traumática. A validação de face e conteúdo do instrumento foi realizada por um comitê de especialistas, compreendendo as etapas preconizadas na literatura. Como parte desse processo, foi realizado o pré-teste, com 10 indivíduos com lesão medular aguda traumática, com até 6 meses de lesão. Resultados: Na maioria dos itens do instrumento, os participantes fizeram sugestões que visavam à modificação de termos técnicos, para serem substituídos ou reformulados para melhor compreensão pelo público alvo. Para a análise de dados o mínimo de concordância estabelecido foi de 80%. Conclusão: A contribuição do estudo refere-se à possibilidade de utilizar uma ferramenta inovadora pela equipe multidisciplinar na prática clínica.


The research aimed to describe the instrument development and validation process based on the brief Core Set of the International Classification of Functioning, Disability and Health for individuals with Acute Spinal Cord Injury. In the methodological study, an instrument was developed to evaluate the functionality of individuals with acute traumatic spinal cord injury. The face and content validation of the instrument was performed by an expert committee, understanding the steps recommended in the literature. As part of this process, a pretest was performed with 10 individuals with acute traumatic spinal cord injury with up to 6 months of injury. In the results, in most items of the instrument, participants made suggestions to modify technical terms, to be replaced or reformulated for better understanding by the target audience. For data analysis the minimum agreement established was 80%. In conclusion, the contribution of the study refers to the possibility of using an innovative tool by the multidisciplinary team in clinical practice.


Subject(s)
Humans , Spinal Cord Injuries/rehabilitation , International Classification of Functioning, Disability and Health , Validation Study
8.
Acta fisiátrica ; 26(1)mar. 2019.
Article in English, Portuguese | LILACS (Americas) | ID: biblio-1046648

ABSTRACT

A disponibilidade de instrumentos para avaliação da saúde sexual é muito importante para uma boa prática clínica, pois permite que os profissionais da área da saúde avaliem e intervenham de forma eficaz, atingindo os melhores padrões de avaliação e intervenção, e assim, melhorem a vida sexual dessa população. Objetivo: Revisar sistematicamente os instrumentos de avaliação da sexualidade em homens e mulheres após a lesão medular disponíveis na literatura, em relação ao seu uso e propriedades de medida. Método: Trata-se de uma revisão sistemática da literatura das bases de dados Pubmed, Lilacs, Scielo e Cinahl, de todos os estudos até maio de 2019, em que a estratégia de busca consistiu na utilização das palavras-chave: sexuality, spinal cord injury, evaluation, assessment e questionnaires. Os artigos identificados pela estratégia de busca inicial foram avaliados conforme critérios de inclusão pré-estabelecidos. Os desfechos foram mecanismos sexuais (excitação, ejaculação, ereção e orgasmo), desejo, satisfação, frequência sexual, ajuste, educação sexual e relação com o parceiro. Os dados foram organizados em tabelas foram apresentados através de uma análise descritiva dos resultados dos estudos incluídos. Resultados: Dezoito estudos atenderam aos critérios de elegibilidade e foram incluídos. Foram encontrados sete instrumentos validados para avaliação da sexualidade em indivíduos com lesão medular, nove genéricos e doze instrumentos para avaliação de fatores possivelmente relacionados a sexualidade. Dois avaliaram as propriedades de medida, sendo que em ambos foram adequadas. Conclusão: Esta revisão identificou um total de 28 instrumentos que foram utilizados na avaliação da sexualidade em indivíduos com lesão medular, entretanto, apenas sete desses instrumentos foram validados.


The availability of tools for sexual health assessment is very important for good clinical practice as it enables health professionals to evaluate and intervene effectively, achieving the best standards of assessment and intervention, and thus improving sex life of this population. Objective: To systematically review the instruments for assessing sexuality in men and women after spinal cord injury available in the literature regarding their use and measurement properties. Methods: This is a systematic literature review of the Pubmed, Lilacs, Scielo and Cinahl databases from all studies up to May 2019, in which the search strategy consisted of using the keywords: sexuality, spinal cord injury, evaluation, assessment and questionnaires. The articles identified by the initial search strategy were evaluated according to the pre-established inclusion criteria. Outcomes were sexual mechanisms (arousal, ejaculation, erection and orgasm), desire, satisfaction, sexual frequency, adjustment, sex education and relationship with the partner. Data were organized into tables were presented through a descriptive analysis of the results of the included studies. Results: Eighteen studies met the eligibility criteria and were included. We found seven validated instruments for assessing sexuality in individuals with spinal cord injury, nine generic and twelve instruments for assessing factors possibly related to sexuality. Two evaluated the measurement properties, and both were adequate. Conclusion: This review identified a total of 28 instruments that were used to assess sexuality in individuals with spinal cord injury, however, only seven of these instruments were validated.


Subject(s)
Humans , Spinal Cord Injuries , Sex Counseling , Sexuality , Disability Evaluation
9.
Rev. Esc. Enferm. USP ; 53: e03445, 2019. tab
Article in English | LILACS (Americas), BDENF | ID: biblio-1003103

ABSTRACT

ABSTRACT Objective: To develop a bank of terms of specialized nursing language based on the International Classification for Nursing Practice (ICNP®) for the care of the person with spinal cord injury. Method: Descriptive, quantitative study guided by the guidelines of terminological studies. Terms were extracted from an official document of the Ministry of Health through use of a computer tool, and were standardized and mapped with the ICNP® Version 2015. Results: We identified 446 relevant terms, of which 265 were equal, 68 were similar, 23 were more comprehensive, 66 were more restricted, and 24 were not in concordance with terms of the ICNP®. Terms classified as equal and similar were considered as constant. Thus, the bank of terms consisted of 333 constant terms and 113 not contained in the classification. Terms included in the Focus, Action, Means and Location axes predominated. Conclusion: The bank of terms will contribute to the construction of the ICNP® terminology subset for the care of people with spinal cord injury.


RESUMEN Objetivo: Elaborar un banco de datos de términos del lenguaje, con base en la Clasificación Internacional para la Práctica de Enfermería (CIPE®), para el cuidado a la persona con lesión medular. Método: Investigación descriptiva, de abordaje cuantitativo, orientada por las directrices de estudios terminológicos. Los términos fueron extraídos de documento oficial del Ministerio de la Salud, mediante uso de herramienta computacional, normalizados y mapeados con la CIPE® Versión 2015. Resultados: Se identificaron 446 términos relevantes, siendo 265 iguales, 68 similares, 23 más amplios, 66 más restrictos y 24 sin concordancia con los términos de aquella clasificación. Los términos clasificados como iguales y similares se consideraron constantes. De ese modo, el banco de términos estuvo constituido de 333 términos constantes y 113 no constantes en la clasificación. Predominaron términos clasificados en los ejes Foco, Acción, Medios y Ubicación. Conclusión: El banco de términos contribuirá a la construcción de un subconjunto terminológico CIPE® para el cuidado a personas con lesión medular.


RESUMO Objetivo: Elaborar um banco de termos da linguagem especializada de enfermagem, com base na Classificação Internacional para a Prática de Enfermagem (CIPE®), para o cuidado à pessoa com lesão medular. Método: Pesquisa descritiva, de abordagem quantitativa, orientada pelas diretrizes de estudos terminológicos. Os termos foram extraídos de documento oficial do Ministério da Saúde, mediante uso de ferramenta computacional, normalizados e mapeados com a CIPE® Versão 2015. Resultados: Identificaram-se 446 termos relevantes, sendo 265 iguais, 68 similares, 23 mais abrangentes, 66 mais restritos e 24 sem concordância com os termos daquela classificação. Os termos classificados como iguais e similares foram considerados constantes. Assim, o banco de termos foi constituído por 333 termos constantes e 113 não constantes na classificação. Predominaram termos classificados nos eixos Foco, Ação, Meios e Localização. Conclusão: O banco de termos contribuirá para a construção de um subconjunto terminológico CIPE® para o cuidado de pessoas com lesão medular.


Subject(s)
Spinal Cord Injuries/nursing , Rehabilitation Nursing/classification , Standardized Nursing Terminology
10.
Rev Rene (Online) ; 20: e40806, 2019. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1012940

ABSTRACT

Objetivo relatar o conhecimento de enfermeiros acerca da assistência de enfermagem às pessoas com lesão medular e disfunção do trato urinário. Métodos estudo transversal, com 19 enfermeiros de hospital terciário. Coletaram-se dados utilizando-se de questionário semiestruturado, validado em nível de conteúdo para esta investigação, contendo variáveis sociodemográficas, profissionais e de conhecimento. Realizaram-se os testes Qui-quadrado, Fisher e Coeficiente de contingência. Resultados detectou-se maior frequência de respostas corretas para cateterismo de demora associado a maior risco de infecção (p<0,001); complicações devido às mudanças no padrão miccional (p<0,001); e desestímulo à ingesta líquida durante a noite (p<0,005). Verificou-se menor percentual de acertos para orientação das manobras de Credé e Valsalva (p<0,001). A instituição de formação dos participantes associou-se ao conhecimento (p=0,032). Conclusão os enfermeiros participantes apresentaram conhecimento satisfatório sobre cuidado de enfermagem às pessoas com lesão medular e disfunção do trato urinário.


Objective to report the knowledge of nurses about nursing care to people with spinal cord injury and urinary tract dysfunction. Methods a cross-sectional study with 19 nurses from a tertiary hospital. Data were collected using a semi-structured questionnaire, validated concerning content for this research, containing sociodemographic, professional and knowledge variables. The Chi-square, Fisher and Contingency Coefficient tests were performed. Results a higher frequency of correct responses was detected for catheterization of delay associated with a higher risk of infection (p<0.001); complications due to changes in micturition pattern (p<0.001); and discouragement to liquid intake at night (p<0.005). There was a lower percentage of correct answers for the orientation of Credé and Valsalva maneuvers (p<0.001). The training institution of participants was associated with knowledge (p=0.032). Conclusion the participating nurses presented satisfactory knowledge about nursing care to people with spinal cord injury and urinary tract dysfunction.


Subject(s)
Spinal Cord Injuries , Urinary Bladder, Neurogenic , Knowledge , Nursing Care
11.
Chinese Medical Journal ; (24): 699-706, 2019.
Article in English | WPRIM (Western Pacific) | ID: wprim-774769

ABSTRACT

BACKGROUND@#Spinal cord injury (SCI) is a worldwide medical concern. This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).@*METHODS@#An acute SCI rat model was established in Sprague-Dawley rats using the Allen method. Sixty rats were divided into four groups (n = 15 in each group): sham-operated, SCI, SCI treated with HBO (SCI + HBO), and SCI treated with both HBO and AMD3100 (an antagonist of CXCR4; SCI + HBO + AMD) groups. The rats were treated with HBO twice a day for 3 days and thereafter once a day after the surgery for up to 28 days. Following the surgery, neurologic assessments were performed with the Basso-Bettie-Bresnahan (BBB) scoring system on postoperative day (POD) 7, 14, 21, and 28. Spinal cord tissues were harvested to assess the expression of SDF-1, CXCR4, and BDNF at mRNA and protein levels, using quantitative real-time polymerase chain reaction, Western blot analysis, and histopathologic analysis.@*RESULTS@#HBO treatment recovered SCI-induced descent of BBB scores on POD 14, (1.25 ± 0.75 vs. 1.03 ± 0.66, P < 0.05), 21 (5.27 ± 0.89 vs. 2.56 ± 1.24, P < 0.05), and 28 (11.35 ± 0.56 vs. 4.23 ± 1.20, P < 0.05) compared with the SCI group. Significant differences were found in the mRNA levels of SDF-1 (mRNA: day 21, SCI + HBO vs. SCI + HBO + AMD, 2.89 ± 1.60 vs. 1.56 ± 0.98, P < 0.05), CXCR4 (mRNA: day 7, SCI + HBO vs. SCI, 2.99 ± 1.60 vs.1.31 ± 0.98, P < 0.05; day 14, SCI + HBO vs. SCI + HBO + AMD, 4.18 ± 1.60 vs. 0.80 ± 0.34, P < 0.05; day 21, SCI + HBO vs. SCI, 2.10 ± 1.01 vs.1.15 ± 0.03, P < 0.05), and BDNF (mRNA: day 7, SCI + HBO vs. SCI, 3.04 ± 0.41 vs. 2.75 ± 0.31, P < 0.05; day 14, SCI + HBO vs. SCI, 3.88 ± 1.59 vs. 1.11 ± 0.40, P < 0.05), indicating the involvement of SDF-1/CXCR4 axis in the protective effect of HBO.@*CONCLUSIONS@#HBO might promote the recovery of neurologic function after SCI in rats via activating the SDF-1/CXCR4 axis and promoting BDNF expression.


Subject(s)
Animals , Blotting, Western , Brain-Derived Neurotrophic Factor , Metabolism , Disease Models, Animal , Hyperbaric Oxygenation , Methods , Male , Rats , Rats, Sprague-Dawley , Receptors, CXCR4 , Metabolism , Receptors, Interleukin-8A , Metabolism , Spinal Cord Injuries , Metabolism , Therapeutics
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-788813

ABSTRACT

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.


Subject(s)
Cell- and Tissue-Based Therapy , Genome , Humans , Induced Pluripotent Stem Cells , Precision Medicine , Regenerative Medicine , Spinal Cord Injuries , Tissue Donors
13.
Article in English | WPRIM (Western Pacific) | ID: wprim-788767

ABSTRACT

OBJECTIVE: Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestin-positive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI.METHODS: rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, S100β, brain derived neurotrophic factor (BDNF), 2’,3’-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor [TGF]-β, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors.RESULTS: rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), β3-tubulin and nestin as well as antiinflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined.CONCLUSION: Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.


Subject(s)
Animals , Brain-Derived Neurotrophic Factor , Dinoprostone , Fibronectins , Flow Cytometry , Fluorescent Antibody Technique , Glial Fibrillary Acidic Protein , Inflammation , Islets of Langerhans , Laminectomy , Macrophages , Mesenchymal Stem Cells , Microtubules , Nestin , Neuroglia , Peroxidase , Rats , Regeneration , Spinal Cord Injuries , Spinal Cord , Stem Cell Transplantation , Stem Cells , Transforming Growth Factors , Vascular Endothelial Growth Factor A , Vimentin , Wounds and Injuries
14.
Article in English | WPRIM (Western Pacific) | ID: wprim-739826

ABSTRACT

OBJECTIVE: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on neurological and functional recovery in patients with central cord syndrome (CCS) involving the upper extremities between the treated and non-treated sides of the treated group and whether the outcomes are comparable to that of the untreated control group. METHODS: Nineteen CCS patients were treated with high-frequency (20 Hz) rTMS over the motor cortex for 5 days. The stimulation side was randomly selected, and all the subjects received conventional occupational therapy during the rTMS-treatment period. Twenty CCS patients who did not receive rTMS were considered as controls. Clinical assessments, including those by the International Standard for Neurological Classification of Spinal Cord Injury, the Jebsen-Taylor Hand Function Test, and the O'Connor Finger Dexterity Test were performed initially and followed up for 1 month after rTMS treatment or 5 weeks after initial assessments. RESULTS: The motor scores for upper extremities were increased and the number of improved cases was greater for the treated side in rTMS-treated patients than for the non-treated side in rTMS-treated patients or controls. The improved cases for writing time and score measured on the Jebsen-Taylor Hand Function Test were also significantly greater in number on the rTMS-treated side compared with the non-treated side and controls. There were no adverse effects during rTMS therapy or the follow-up period. CONCLUSION: The results of the application of high-frequency rTMS treatment to CCS patients suggest that rTMS can enhance the motor recovery and functional fine motor task performance of the upper extremities in such individuals.


Subject(s)
Central Cord Syndrome , Classification , Fingers , Follow-Up Studies , Hand , Humans , Motor Cortex , Occupational Therapy , Spinal Cord Injuries , Task Performance and Analysis , Transcranial Magnetic Stimulation , Upper Extremity , Writing
15.
Article in English | WPRIM (Western Pacific) | ID: wprim-739331

ABSTRACT

Recovery from central nervous system (CNS) injury, such as stroke or spinal cord injury (SCI), largely depends on axonal regeneration, and the neuronal and glial cells plasticity in the lesioned tissue. The lesioned tissue following CNS injury forms a scar that is composed of astrocytes and mixed with connective tissues. At the glial scar, the regenerating axon forms dystrophic endbulbs which do not regenerate and grow beyond the glial scar without a suitable environment. Along with the astrocytes, microglia are also suspected of being involved in necrotic and apoptotic neuronal cell death and the early response to axonal damage in CNS injury. The inflammatory response, a major component of secondary injury and controlled by the microglia, plays a pivotal role in nerve injury and control the regenerative response. As a result, it is very important to control the glial cell function in order to assure the recovery of the CNS injury. Studies have suggested that agmatine, a L-arginine derived primary amine, is a potential modulator of glial cell function after CNS injuries. Agmatine was found to possess anti-inflammatory and neuroprotective characteristics that benefited the rehabilitation process following CNS injury. In this review, we will discuss the effect of agmatine on glial cells in the process of recovery after CNS injury.


Subject(s)
Agmatine , Arginine , Astrocytes , Axons , Cell Death , Central Nervous System , Cicatrix , Connective Tissue , Microglia , Neuroglia , Neurons , Plastics , Regeneration , Rehabilitation , Spinal Cord Injuries , Stroke
16.
Article in English | WPRIM (Western Pacific) | ID: wprim-739328

ABSTRACT

To investigate vitamin D status according to the diseases in patients admitted to the department of rehabilitation medicine. In total, 282 patients admitted to the department of rehabilitation medicine in our hospital were included. Patients were classified into 4 groups according to ailment: stroke, traumatic brain injury, spinal cord injury, and fracture. All patients were also classified as ambulatory or non-ambulatory. Serum 25-hydroxyvitamin D (25[OH]D) levels were estimated at admission and at discharge. Bone mineral density (BMD) and ionized calcium levels were also measured. All subjects completed the Desmond Fall Risk Questionnaire for fall risk assessment. In total, 92 patients (59 males and 33 females; mean age, 69.09 ± 9.4 years) was enrolled. Low serum 25(OH)D levels (6–28 ng/mL) were observed in all patients in this study, and these were lower in the group of fractures resulting from falls than in the group of strokes (p < 0.05). Significant correlations were found between BMD and ionized calcium levels, Desmond Fall Risk Questionnaire scores and BMD, and questionnaire scores and serum 25(OH)D (p < 0.05). Serum 25(OH)D levels were lower in the department of rehabilitation medicine inpatients in our study than in the general population. The ambulatory patients had higher serum 25(OH)D levels at discharge than the non-ambulatory patients'. The hospitalized rehabilitation patients had lower serum 25(OH)D compared with the community. There were lower serum 25(OH)D levels in patients with fractures and non-ambulatory groups. We should pay attention to serum vitamin D levels of rehabilitation center inpatients.


Subject(s)
Accidental Falls , Bone Density , Brain Injuries , Calcium , Female , Humans , Inpatients , Male , Rehabilitation Centers , Rehabilitation , Risk Assessment , Spinal Cord Injuries , Stroke , Vitamin D , Vitamins
17.
Rev Rene (Online) ; 20: e41281, 2019. tab
Article in Portuguese | LILACS (Americas) | ID: biblio-1040996

ABSTRACT

Objetivo identificar o conhecimento de enfermeiros de hospital de ensino universitário sobre bactérias multirresistentes. Métodos estudo transversal e prospectivo, com participação de 109 enfermeiros. Coleta de dados por meio de questionário com questões abertas e fechadas. A análise estatística, seu deu por meio do programa Statistical Package for the Social Sciences. Resultados 67,0% dos participantes consideraram o conhecimento adquirido na graduação relativo a bactérias multirresistentes insuficiente para o enfrentamento destas, com predomínio dos formados anterior ao ano de 2005; do processo de transmissão, predominaram os profissionais mais jovens. Conclusão o conhecimento sobre bactérias multirresistentes foi maior entre profissionais mais jovens, de formação mais recente, com iniciativa individual para expandir o conhecimento sobre o tema e participação em treinamentos em serviço. O Serviço de Controle de Infecção Hospitalar foi a principal fonte provedora de conhecimentos para os enfermeiros participantes do estudo.


Objective to identify the knowledge of nurses of a teaching hospital about multidrug resistant bacteria. Methods cross-sectional and prospective study with the participation of 109 nurses. Data collection used a questionnaire with open and objective questions. Statistical analysis used the Statistical Package for the Social Sciences software. Results 67.0% of the participants considered the knowledge acquired in the graduation regarding multi-resistant bacteria insufficient to deal with them, with a predominance of professionals graduated before the year 2005; in the transmission process, younger professionals predominated. Conclusion knowledge about multidrug-resistant bacteria was higher among younger, more recently graduated professionals, with proactive enough to expand knowledge about the subject and to participate in in-service training. The Hospital Infection Control Service was the main source of knowledge for nurses participating in the study.


Subject(s)
Spinal Cord Injuries , Urinary Bladder, Neurogenic , Knowledge , Nursing Care
18.
Article in English | WPRIM (Western Pacific) | ID: wprim-765625

ABSTRACT

STUDY DESIGN: Animal study. OBJECTIVES: To investigate the effects of microelectric treatment by transcutaneous electrical nerve stimulation (TENS) on functional recovery and histological changes in a rat model of spinal cord injury (SCI). SUMMARY OF LITERATURE REVIEW: The effects of TENS on spasticity and its underlying mechanisms remain unclear. MATERIALS AND METHODS: SCI was induced by a 1.5-mm impactor with 200,000–260,000 dyne after laminectomy. Rats were divided into the following groups: group I (normal control), group II (microelectric treatment of 0 A), group III (microelectric treatment of 100 µA for 1 hr/day), group IV (microelectric treatment of 400 µA for 1 hr/day), and group V (microelectric treatment of 400 µA for 24 hr/day). After inducing SCI, rats were assessed by a sensory test with von Frey filaments and the locomotor recovery test (BBB rating scale) at 1, 4, 7, 14, 21, and 28 days. To evaluate spinal cord damage, histopathological studies were performed with hematoxylin and eosin. Brain-derived neurotrophic factor (BDNF) and TrkB immunohistochemistry studies were performed at 28 days. RESULTS: In groups IV and V, the BBB score had significantly improved on days 21 and 28 after SCI, and the TENS-treated groups showed significant neuronal recovery. After SCI, groups IV and V showed a significant recovery of locomotor function and the motor sensory response of the withdrawal threshold to 3.5 g. In addition, necrotic tissue and cystic spaces in the spinal cord were significantly reduced and BDNF/TrkB-positive cells were highly expressed in groups III, IV, and V. CONCLUSIONS: Microelectric treatment can play a role in facilitating the recovery of locomotion following SCI.


Subject(s)
Animals , Brain-Derived Neurotrophic Factor , Eosine Yellowish-(YS) , Hematoxylin , Immunohistochemistry , Laminectomy , Locomotion , Models, Animal , Muscle Spasticity , Neurons , Rats , Spinal Cord Injuries , Spinal Cord , Transcutaneous Electric Nerve Stimulation
19.
Article in English | WPRIM (Western Pacific) | ID: wprim-765386

ABSTRACT

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.


Subject(s)
Cell- and Tissue-Based Therapy , Genome , Humans , Induced Pluripotent Stem Cells , Precision Medicine , Regenerative Medicine , Spinal Cord Injuries , Tissue Donors
20.
Article in English | WPRIM (Western Pacific) | ID: wprim-765338

ABSTRACT

OBJECTIVE: Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestin-positive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. METHODS: rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, S100β, brain derived neurotrophic factor (BDNF), 2’,3’-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor [TGF]-β, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors. RESULTS: rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), β3-tubulin and nestin as well as antiinflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined. CONCLUSION: Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.


Subject(s)
Animals , Brain-Derived Neurotrophic Factor , Dinoprostone , Fibronectins , Flow Cytometry , Fluorescent Antibody Technique , Glial Fibrillary Acidic Protein , Inflammation , Islets of Langerhans , Laminectomy , Macrophages , Mesenchymal Stem Cells , Microtubules , Nestin , Neuroglia , Peroxidase , Rats , Regeneration , Spinal Cord Injuries , Spinal Cord , Stem Cell Transplantation , Stem Cells , Transforming Growth Factors , Vascular Endothelial Growth Factor A , Vimentin , Wounds and Injuries
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