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1.
Journal of Experimental Hematology ; (6): 1050-1055, 2021.
Article in Chinese | WPRIM | ID: wpr-888517

ABSTRACT

OBJECTIVE@#To investigate the effect of sulforaphane (SFN) on G@*METHODS@#KG1a and KG1cells were treated by different concentrations of SFN for 48 h. Flow cytometry (FCM) was used to analyze the phase distribution of cell cycle. High-throughput sequencing was used to detect the effect of SFN on the expression of cell cycle related genes in KG1a cells. The mRNA expression of P53, P21, CDC2 and CyclinB1 were detected by qPCR. The protein expression of P53, CDC2, P-CDC2 and CyclinB1 were detected by Western blot.@*RESULTS@#Cells in the G@*CONCLUSION@#SFN induces leukemia cells to block in G


Subject(s)
Cell Cycle , Humans , Isothiocyanates/pharmacology , Leukemia, Myeloid, Acute , Mitosis , Sulfoxides
2.
Arch. endocrinol. metab. (Online) ; 62(5): 545-551, Oct. 2018. tab, graf
Article in English | LILACS | ID: biblio-983794

ABSTRACT

ABSTRACT Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0.1 IU/mL). Subjects and methods: We analyzed 46 patients with SCH due to the use of TSH suppressive therapy with LT4 after total thyroidectomy along with 6 control euthyroid individuals (3M and 3W). Patients were divided into two groups, G1 with TSH ≥ 0.1-0.4 IU/mL (n = 25; and 7M 14W) and G2 with TSH < 0.1 IU/mL (n = 25; and 4M 21W). Venous blood samples were collected to measure the levels of markers for oxidative damage (TBARS, FOX and protein carbonylation), muscle and liver damage (CK, AST, ALT, GGT) and antioxidants (GSH, GSSG and catalase). Results: Individuals in G2 showed a GSH/GSSG ratio ~ 30% greater than those in G1 (p = 0.004) and a catalase activity that was 4 times higher (p = 0.005). For lipid peroxidation, the levels measured in G2 were higher than both control and G1 (p = 0.05). No differences were observed for both protein carbonyl markers. G1 and G2 presented with greater indications of cell injury markers than the control group. Conclusion: TSH suppression therapy with LT4 that results in subclinical hyperthyroidism can cause a redox imbalance. The greater antioxidant capacity observed in the more suppressed group was not sufficient to avoid lipid peroxidation and cellular damage.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Thyroxine/pharmacology , Thyrotropin/antagonists & inhibitors , Hyperthyroidism/drug therapy , Oxidation-Reduction/drug effects , Phenols/blood , Reference Values , Sulfoxides/blood , Lipid Peroxidation/drug effects , Catalase/blood , Case-Control Studies , Cross-Sectional Studies , Thiobarbituric Acid Reactive Substances/analysis , Oxidative Stress/drug effects , Glutathione Disulfide/blood , Protein Carbonylation , Glutathione/blood , Hyperthyroidism/metabolism
3.
São Paulo; s.n; s.n; 2017. 166p ilus, tab.
Thesis in Portuguese | LILACS | ID: biblio-874966

ABSTRACT

Neste trabalho promovemos a síntese de sulfóxidos vinílicos ?-substituídos através da reação de acoplamento cruzado de Suzuki-Miyaura. Também foi feita a síntese de sulfóxidos enínicos inéditos, pela adição do nucleófilo no carbono ß-sulfóxido. Esses compostos eram passíveis de serem submetidos a reação de rearranjo de Pummerer aditivo e assim gerarem uma pequena biblioteca de compostos α-tioaldeídos. Um desses aldeídos sintetizados foi empregado na reação de formação de uma imina propargílica, com consequente reação de CuAAC formando iminas triazólicas. Outras iminas arílicas foram sintetizadas, passando por uma etapa de redução, com intuito de se obter a amina livre, para que fosse feita a reação de ciclização com auxílio de um agente eletrofílico. Outra classe de composto organoenxofre foi sintetizada, as N-sulfinil imina, que após a reação de acoplamento cruzado de Sonogashira, com consequente remoção de um grupo protetor e a formação do anel heterocíclico, foram obtidos compostos triazólicos N-sulfinil imínicos.


In this work we promote the synthesis of α-substituted vinylic sulfoxides through the Suzuki-Miyaura cross coupling reaction. Also the synthesis of unpublished enynic sulfoxides was made, by the addition of the nucleophile in the ß-sulfoxide carbon. These compounds were susceptible to additive Pummerer rearragement reaction and thus generated a small library of compounds. One of these aldehydes synthesized was used in the formation reaction of a propargyl imine, with consequent CuAAC reaction, forming triazol imines. Other aryl imines were synthesized, undergoing a reduction step, in order to obtain the free amine, so that the cyclization reaction was carried out with the aid of an electrophilic agent. Another class of organosulfur compound was synthesized, the N-sulfinyl imine, which after the Sonogashira cross-coupling reaction, with consequent removal of a protecting group and formation of the heterocyclic ring, N-sulfinyl imine triazolic compounds were obtained.


Subject(s)
Imines , Sulfides , Sulfoxides , Magnetic Resonance Spectroscopy
4.
Electron. j. biotechnol ; 16(6): 1-1, Nov. 2013. ilus, tab
Article in English | LILACS | ID: lil-696542

ABSTRACT

Background: Natural sulforaphane (SF) has been of increasing interest for nutraceutical and pharmaceutical industries due to its anti-cancer effect. The main objective of the present work was to optimize the production of SF from broccoli seed using response surface methodology. Results: Three major factors (hydrolysis time, water volume and ethyl acetate volume) were screened out through Plackett-Burman (PB) factorial design. The methods of steepest ascent combined with central composite design (CCD) were employed for optimization of the SF production process. The optimal extraction conditions for SF production were a hydrolysis time of 13 min, a hydrolysis volume/weight ratio of 2.9:1 (v/g) and an extraction volume/weight ratio of 17.5:1 (v/g). The maximum SF yield was 14.8 ± 0.1 mg/g, a value that was in perfect agreement with the actual experimental value (14.8 mg/g). Conclusions: These results suggested that PB design combined with CCD were proved effective in screening and optimization of the parameters of SF production.


Subject(s)
Seeds/metabolism , Sulfoxides/metabolism , Brassica , Isothiocyanates/metabolism , Sulfoxides/analysis , Data Interpretation, Statistical , Chromatography, High Pressure Liquid , Isothiocyanates/analysis
5.
Article in English | WPRIM | ID: wpr-728099

ABSTRACT

The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion (Fe3+) and xylenol orange, often called FOX assay and subsequent monitoring of absorbance values of the reactant at 540 nm. The reaction was to some extent pH-dependent and detection sensitivity was greatest at pH 1.75. Genistein liposomal gel demonstrated better anti-oxidative effect with regard to lowering hydrogen peroxide levels elevated by UVB irradiation compared to genistein-suspended gel. A linear relationship has been observed between anti-oxidative effect of genistein and drug deposition in the skin tissue. Genistein liposomal gel resulting in the localization of the drug in the deeper skin led to improved anti-oxidative effect compared to genistein gel. The suggested method for evaluation of oxidation of the skin can be used as a tool to screen effective anti-oxidative agents and their delivery systems acting on the skin.


Subject(s)
Citrus sinensis , Genistein , Hydrogen Peroxide , Hydrogen-Ion Concentration , Phenols , Skin , Sulfoxides
6.
Int. j. morphol ; 29(3): 816-820, Sept. 2011. ilus
Article in English | LILACS | ID: lil-608663

ABSTRACT

The aim of this work was to evaluate the effect of albendazole sulphoxide (ABZSO) administered to Balb C mice prior to mating on fertilization rate and preimplantational embryo development. Twenty four female mice 5-8 weeks of age were superovulated by intraperitoneal injection of 7.5 UI of equine chorionic gonadotropin (eCG, Novormon®, Laboratorios Syntex S.A., Argentina); 48 h later they received 10 IU of human chorionic gonadotropin (hCG, Profasi®, Laboratorios Serono, Méjico) and were paired with males of proven fertility. Females received 100 mg/kg or 200 mg/kg of ABZSO orally at the time of hCG administration, prior to mating. The control group received carboxymethylcellulose, vehicle used to prepare the drug suspension. Pregnant females were killed by cervical dislocation at day 4 of pregnancy and non fertilized oocyte and embryos were flushed from uteri. The possible effects of ABZSO were evaluated considering the fertilization rate, the total number of collected embryos per female; the percentage of embryos morphologically normal; the differentiation rate (determined by the relation between the number of blastocyst and the total of morphologically normal embryos) and the cleavage rate determined by counting the nuclei. The variables were analyzed on a per litter basis using the Kruskal-Wallis test. The fertilization rate was lower in females administered ABZSO at a dose of 200 mg/kg (P<0.05). However, no statistically significant differences were found in the embryonic parameters after the administration of 100 mg/kg or 200 mg/kg of ABZSO compared to the untreated control group (P>0.05). In conclusion, a single acute exposure to ABZSO prior to mating at around the time of fertilization at a dose higher than the one usually administered in human and veterinary medicine affects the fertilization rate but it has no adverse effects on early embryo development.


El objetivo de este trabajo fue evaluar el efecto de albendazol sulfóxido (ABZSO) administrado a ratonas Balb C previo al apareamiento, sobre la tasa de fertilización y el desarrollo embrionario preimplantacional. Se utilizaron 24 hembras de 5 a 8 semanas de edad las que fueron inducidas a superovular por inyección intraperitoneal de 7,5 UI de gonadotrofina coriónica equina (eCG, Novormon®, Laboratorios Syntex S.A. Argentina) seguidas, 48 h más tarde por 10 UI de gonadotrofina coriónica humana (hCG, Profasi®, Laboratorios Serono, México). Al momento de recibir la dosis de hCG, fueron apareadas con machos de fertilidad probada. Las hembras fueron dosificadas oralmente con ABZSO disuelto en carboximetilcelulosa en dosis de 100 mg/kg (Grupo 100) y 200 mg/kg (Grupo 200) previo al apareamiento. El grupo control recibió carboximetilcelulosa. Las hembras preñadas fueron sacrificadas por dislocación cervical en el día 4 de preñez y se recolectaron ovocitos sin fertilizar y embriones preimplantacionales mediante el lavado de cuernos uterinos. Se determinó la tasa de fertilización, el número promedio de embriones recolectados por hembra, el porcentaje de embriones morfológicamente normales, el porcentaje de diferenciación y la velocidad de clivaje estimada por recuento de núcleos. Las variables fueron analizadas sobre la base de la camada utilizando el test de Kruskal-Wallis. La tasa de fertilización resultó menor para hembras que recibieron albendazol sulfóxido a razón de 200 mg/kg de peso (P<0,05); no obstante, no se observaron diferencias significativas en los parámetros embrionarios luego de la administración de 100 mg/kg ó 200 mg/kg de ABZSO comparado con el grupo control (P>0,05). En conclusión, la exposición aguda de ABZSO realizada previo al apareamiento a una dosis mayor de aquella utilizada en medicina humana y veterinaria afecta la tasa de fertilización pero no muestra efectos adversos sobre el desarrollo embrionario temprano.


Subject(s)
Mice , Albendazole/administration & dosage , Albendazole/therapeutic use , Embryonic Development , Sulfoxides/administration & dosage , Mice, Inbred BALB C/embryology , Reproduction
7.
Article in English | IMSEAR | ID: sea-91824

ABSTRACT

AIM OF STUDY: Quality of life (QOL) as outcome during treatment of acid peptic disease has been studied, but, peptic perforation, which is the commonest complication of acid peptic disease, has not been studied in the light of QOL outcome. The present-study addresses the important issue of QOL after peptic perforations. METHODS: This prospective study was carried on 51 adult consecutive survivors of peptic perforation managed in Gastrointestinal Surgery Unit, Department of Surgery, Government NSCB Medical College and Hospital, Jabalpur (MP) India. These underwent exploratory laparotomy with repair of perforation, and subsequently were discharged on anti-ulcer therapy (Pantoprazole 40 mg once a day) for 6 weeks. The instrument chosen to study their QOL was gastrointestinal quality of life index (GIQLI). Patients were assessed before they underwent surgery and 3 months and 6 months after operation. RESULTS: The overall GIQLI score (t = 20.1, p < 0.00 at 3 months; t = 8.2, p < 0.001 at 6 months) as well as its G I core (t = 14.5, p < 0.001 at 3 months; t = 7.3, p < 0.001 at 6 months), G I disease specific (t = 12.9, p < 0.001 at 3 months; t = 2.6, p < 0.02 at 6 months), psychological (t = 15.4, p < 0.001 at 3 months; t = 3.5, p < 0.001 at 6 months) and physical and social components (t = 10.9, p < 0.001 at 3 months; t = 4.2, p < 0.001 at 6 months) significantly increased over 3 and 6 months of follow-up, reflecting improvement in quality of life as perceived by the patients. Variations in the pattern of recovery, based on age and gender were not seen in the present study. CONCLUSION: Peptic perforation does not result in any long lasting impairment of QOL and the QOL improves to near normal in 6 months time after the perforation.


Subject(s)
2-Pyridinylmethylsulfinylbenzimidazoles , Adult , Aged , Aged, 80 and over , Anti-Ulcer Agents/therapeutic use , Benzimidazoles/therapeutic use , Digestive System Surgical Procedures , Female , Humans , Male , Middle Aged , Omeprazole/analogs & derivatives , Outcome Assessment, Health Care , Peptic Ulcer Perforation/drug therapy , Prospective Studies , Quality of Life , Surveys and Questionnaires , Sickness Impact Profile , Sulfoxides/therapeutic use
8.
Acta Pharmaceutica Sinica ; (12): 370-373, 2004.
Article in Chinese | WPRIM | ID: wpr-302806

ABSTRACT

<p><b>AIM</b>To study the chiral inversion of dextropantoprazole in human.</p><p><b>METHODS</b>Three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed and used to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasma samples were measured on a Chiral-AGP column. The plasma concentration of each enantiomer was then calculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured.</p><p><b>RESULTS</b>The AUC0-t of levopantoprazole was only 1.5% of the total AUC0-t of enantiomers.</p><p><b>CONCLUSION</b>The chiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazol.</p>


Subject(s)
2-Pyridinylmethylsulfinylbenzimidazoles , Administration, Oral , Adult , Anti-Ulcer Agents , Blood , Chemistry , Pharmacokinetics , Area Under Curve , Benzimidazoles , Blood , Chemistry , Pharmacokinetics , Chromatography, High Pressure Liquid , Humans , Male , Omeprazole , Blood , Chemistry , Pharmacokinetics , Stereoisomerism , Sulfoxides , Blood , Chemistry , Pharmacokinetics
9.
São Paulo; s.n; 2004. 191 p. ilus, graf.
Thesis in Portuguese | LILACS | ID: lil-399426

ABSTRACT

Esta tese descreve, em três diferentes capítulos, a preparação de quatro produtos naturais com atividade biológica reconhecida. O primeiro se refere à síntese de dois ácidos carboxílicos diacetilênicos, os ácidos montipóricos A e B, isolados dos ovos do coral duro Montipora digitata e que apresentam atividade citotóxica e antibacteriana. Estas sínteses foram alcançadas utilizando-se reações de acoplamento de acetilenos e eterificação por CTF. Reações de transposição de ligação tripla e redução de acetileno terminal por semi-hidrogenação com Lindlar/`H IND. 2', ou hidroteluração/transmetalação Te-Li, são discutidas. O segundo capítulo descreve a síntese do virol C, um diol poliacetilênico análogo à cicutoxina, isolado como um dos componentes tóxicos da planta Cicuta virosa...


Subject(s)
Acetylene , Carboxylic Acids/chemical synthesis , Biological Factors , Cicuta , Chemistry, Pharmaceutical , Sulfoxides
10.
Acta cir. bras ; 18(6): 542-544, nov.-dez. 2003. ilus, tab
Article in Portuguese | LILACS | ID: lil-360214

ABSTRACT

OBJETIVO: Avaliar os efeitos do omeprazol e do pantoprazol sobre a regeneração hepática após hepatectomia parcial. MÉTODOS: Cinqüenta e oito ratos Wistar machos foram divididos em 4 grupos: Grupo SHAM, Grupo HP, Grupo PANTO e Grupo OMEP. Eles foram submetidos a hepatectomia parcial de 67 por cento (Grupos HP, PANTO e OMEP) ou laparotomia (Grupo SHAM). Os fígados foram removidos 32 e 56 horas após a operação. Depois, os animais foram sacrificados. Em todos os grupos, as substâncias (solução salina, omeprazol e pantoprazol) foram aplicadas diariamente a partir do momento em que foram operados até o sacrifício. RESULTADOS: O índice de mitose no Grupo SHAM não foi significativo. Trinta e duas horas após a hepatectomia, a contagem de mitoses foi de 1,2 ± 1,09 para o Grupo HP, 1,2 ± 1,6 para o Grupo OMEP e 2,6 ± 3,2 para o Grupo PANTO. Na análise após 56 horas, os valores foram 1,6 ± 0,89 para o HP, 2 ± 1,8 para o OMEP e 2,6 ± 0,54 para o PANTO. Esses resultados não foram estatisticamente significativos. CONCLUSAO: O omeprazol e o pantoprazol, agentes inibidores da bomba de prótons (H+, K+-ATPase), não interferem na regeneração hepática 32 e 56 horas após hepatectomia parcial a 67 por cento em ratos.


Subject(s)
Animals , Male , Rats , Anti-Ulcer Agents , Benzimidazoles/pharmacology , Hepatectomy , Omeprazole , Liver Regeneration , Sulfoxides/pharmacology , Rats, Wistar
11.
Acta gastroenterol. latinoam ; 33(4): 199-203, 2003. tab
Article in Spanish | LILACS | ID: lil-359984

ABSTRACT

OBJECTIVE: To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND METHODS: Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then "wash out" for 7 days and thereafter 7 more days' therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end. RESULTS: 24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test: (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65. CONCLUSIONS: According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Benzimidazoles/pharmacology , Enzyme Inhibitors/pharmacology , Gastric Acid , Omeprazole/pharmacology , Proton Pumps/antagonists & inhibitors , Sulfoxides/pharmacology , Analysis of Variance , Benzimidazoles/administration & dosage , Cross-Over Studies , Enzyme Inhibitors/administration & dosage , Gastric Acidity Determination , Hydrogen-Ion Concentration , Manometry , Omeprazole/administration & dosage , Random Allocation , Sulfoxides/administration & dosage , Time Factors
13.
Vet. Méx ; 31(4): 309-313, oct.-dic. 2000. tab, graf
Article in Spanish | LILACS | ID: lil-304586

ABSTRACT

El objetivo del presente trabajo fue comparar la eficacia del sulfóxido de albendazol y de levamisol contra H. contortus en ovinos infectados experimentalmente. Se formaron tres grupos homogéneos en cuanto a eliminación de huevos. grupo I (n = 19) fue tratado con sulfóxido de albendazol, grupo II (n = 19) con levamisol, ambos vía intramuscular, a la dosis recomendada por el fabricante. El Grupo III (n = 18) no recibió tratamiento y sirvió como testigo. Se calculó el porcentaje de reducción de huevos en heces (PRH), el intervalo de confianza al 95 por ciento (IC) y el porcentaje de animales positivos (PAP) a los siete y catorce días después del tratamiento (DPT). A los siete DPT, el grupo I tuvo un PRH de 65.9 por ciento (IC = 44 por ciento-79 por ciento) y un PAP = 100 por ciento, mientras que en el grupo II el PRH fue de 99.7 por ciento (IC = 99 por ciento -100 por ciento) y el PAP de 15.8 por ciento. A los 14 DPT, el grupo I tuvo un PRH de 66.2 por ciento (IC = 13 por ciento-70 por ciento) y un PAP de 84 por ciento. En el grupo II el PRH fue de 100 por ciento (IC = 100 por ciento) y el PAP fue del 0 por ciento. El grupo III siempre tuvo un PAP del 100 por ciento. Los resultados indican la presencia de una población de H. contortus resistente al sulfóxido de albendazol. Aunque existen trabajos sobre resistencia de este parásito a bencimidazoles en México, ésta no se había registrado en contra del sulfóxido de albendazol inyectado, el cual está considerado como de primera elección contra estos nematodos


Subject(s)
Animals , Albendazole , Drug Resistance , Haemonchus , Sheep , Sulfoxides/pharmacology
14.
Egyptian Journal of Chemistry. 2000; 43 (2): 177-85
in English | IMEMR | ID: emr-53709

ABSTRACT

The effect of substituent for the reactions of 2,4-dinitrophenyl aryl sulphoxide [la], sulphones [2a-i] and sulphides [3a-h] with hydroxide ion in 80% ethanol-water [v/v] at 25C was investigated. The relative mobility of thioaryl, sulfinylphenyl and sulfonyl aryl leaving groups was also discussed


Subject(s)
Hydroxides , Sulfoxides , Sulfones , Sulfides , Ethanol
16.
Rev. gastroenterol. Méx ; 63(2): 66-71, abr.-jun. 1998. tab, ilus
Article in Spanish | LILACS | ID: lil-240892

ABSTRACT

Objetivo. Comparar la eficacia y tolerabilidad de una terapia triple contra una doble basadas en pantoprazol para erradicar Helicobacter pylori (H. pylori) en pacientes mexicanos con úlcera duodenal activa. Antecedentes. El tratamiento de la enfermedad ulcerosa péptica ha sido revolucionada con el hecho de que H. pylori generalmente induce grastritis crónica y se asocia con enfermedad ulcerosa péptica y la curación de la infección previene la recaída de la úlcera. Material y métodos. 74 pacientes H. pylori positivos con diagnóstico de úlcera duodenal activa recibieron ya sea pantoprazol 40 mg dos veces al día en combinación con claritromicina 500 mg tres veces al día en combinación con claritromicina 500 mg tres veces al día y amoxicilina 1 g dos veces al día (esquema triple = PAC) o bien pantoprazol en combinación con claritromicina y placebo (esquema doble = PC) durante 14 días. Con el fin de asegurar la completa cicatrización de la úlcera, todos los pacientes recibieron 2 semanas adicionales de pantoprazol 40 mg una vez al día. La prueba de aliento con urea marcada con 14C fue el criterio principal para determinar el índice de erradicación con < 150 desintegraciones por minuto (DPM) para considerar a un paciente erradicado. En todos los pacientes se realizaron cultivos y pruebas de susceptibilidad a antibioticos (E-test) así como estudio histológico. Resultados. En el análisis protocolo correcto (n=66) los índices de erradicación fueron: PAC 93.5 por ciento vs 54.3 por ciento (p<0.001); el 76 por ciento de cepas de H. pylori fueron resistentes al metronizadol. La tolerancia y apego al tratamiento fue excelente en ambos grupos. Conclusiones. La triple terapia (PAC) demostró ser superior a la doble (PC) para la erradicación de H. pylori en pacientes mexicanos con úlcera duodenal activa


Subject(s)
Humans , Male , Adolescent , Adult , Middle Aged , Amoxicillin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Anti-Ulcer Agents/administration & dosage , Benzimidazoles/administration & dosage , Clarithromycin/administration & dosage , Data Interpretation, Statistical , Enzyme Inhibitors , Helicobacter Infections/diagnosis , Helicobacter Infections/drug therapy , Helicobacter pylori , Protein Synthesis Inhibitors/administration & dosage , Penicillins/administration & dosage , Placebos , Sulfoxides/administration & dosage , Duodenal Ulcer/diagnosis , Duodenal Ulcer/drug therapy
17.
Rev. gastroenterol. Méx ; 63(1): 11-6, ene.-mar. 1998. tab, ilus
Article in Spanish | LILACS | ID: lil-240883

ABSTRACT

Objetivo. Comparar y contrastar la eficacia y tolerabilidad de un inhibidor de bomba de protones, pantoprazol, con un antagonista de los receptores H2, ranitidina, en el tratamiento de pacientes con esofagitis por reflujo moderada y severa. Antecedentes. La esofagitis por reflujo es una enfermedad común que afecta del 5 al 10 por ciento de la población mundial. El reflujo ácido juega un papel importante en el desarrollo de la enfermedad, así como las alteraciones en la motilidad del esófago y estómago. Pacientes y métodos. 315 pacientes (intento de tratamiento) con esofagitis por reflujo (Savary-Miller (SM) grados II y III) confirmada endoscópicamente fueron reclutados en este estudio por 46 investigadores mexicanos en nueve centros. Los pacientes recibieron ya sea pantoprazol 40 mg una vez al día o 150 mg de ranitidina dos veces al día en este estudio doble ciego, aleatorizado, con comparación de grupos paralelos. Los pacientes que no alcanzaron una cicatrización endoscópica completa después de cuatro semanas de tratamiento recibieron cuatro semanas adicionales. La tolerabilidad a los medicamentos fue valorada a través del informe de eventos adversos durante el estudio. Resultados. Después de cuatro semanas de tratamiento con pantoprazol el 81 por ciento de los pacientes con SMII y 67 por ciento de los pacientes con SM III habían cicatrizado; en contraste en el grupo tratado con ranitidina cicatrizaron solamente 67 y 30 por ciento respectivamente, todos los resultados están expresados en pacientes protocolo correcto. Después de ocho semanas de tratamiento los índices de cicatrización para el grupo pantoprazol se incrementaron a 94 por ciento y en el grupo de ranitidina 74 por ciento (p=0.001). La incidencia de eventos adversos fue menor del 2 por ciento en ambos grupos de tratamiento, por lo tanto encontramos que ambas terapias fueron bien toleradas. Conclusiones. El pantoprazol es superior a la ranitidina en el tratamiento de esofagitis por reflujo moderada y severa y ambos tratamientos son igualmente bien tolerados


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Anti-Ulcer Agents/administration & dosage , Anti-Ulcer Agents/therapeutic use , Benzimidazoles/administration & dosage , Benzimidazoles/therapeutic use , Data Interpretation, Statistical , Double-Blind Method , Esophagitis, Peptic/classification , Esophagitis, Peptic/drug therapy , Histamine H2 Antagonists/administration & dosage , Histamine H2 Antagonists/therapeutic use , Enzyme Inhibitors/administration & dosage , Enzyme Inhibitors/therapeutic use , Placebos , Prospective Studies , Ranitidine/administration & dosage , Ranitidine/therapeutic use , Sulfoxides/administration & dosage , Sulfoxides/therapeutic use , Time Factors
18.
Vet. Méx ; 29(1): 1-6, ene.-mar. 1998. tab
Article in Spanish | LILACS | ID: lil-241022

ABSTRACT

Después de la corrección de una obstrucción intestinal se producen radicales libres derivados del oxígeno, que se forman durante la isquemia y la reperfusión del área (síndrome de reperfusión). Para valorar hasta qué punto puede resolverse una obstrucción intestinal contrarrestando estos factores con medicamentos, se indujo una obstrucción intestinal a nivel del yeyuno en 10 perros, que se mantuvo durante 120 minutos. A los 110 minutos se administró una combinación de sulfóxido de dimetilo y naloxona con el objetivo de evaluar su eficacia para contrarrestar los efectos de la reperfusión. Los perros de dividieron en dos grupos de 5 animales cada uno: grupo testigo y grupo experimental. Al primer grupo se le administró solución salina fisiológica en cantidad equivalente al volumen administrado de fármacos que se les aplicó al segundo grupo, a este último se le suministró la combinación sulfóxido de dimetilo (a dosis de 1 g/kg de peso a una dilución de 10 por ciento) y naloxona (a dosis de 0.04 mg/kg de peso). Los resultados sugieren que dicha combinación puede ser eficaz para disminuir las lesiones provocadas por los radicales libres, también es eficaz para mejorar la condición del sujeto, al contrarrestar los efectos sistémicos de la reperfusión


Subject(s)
Animals , Dogs , Disease Models, Animal , Dogs , Intestines/drug effects , Naloxone/administration & dosage , Intestinal Obstruction/drug therapy , Intestinal Obstruction/veterinary , Reperfusion Injury/drug therapy , Sulfoxides/administration & dosage , Free Radicals
19.
Dermatol. rev. mex ; 36(3): 159-64, mayo-jun. 1992. ilus, tab
Article in Spanish | LILACS | ID: lil-117379

ABSTRACT

En ocho pacientes con cicatriz queloide se realizó un estudio abierto, prospectivo y experimental con aplicación tópica de dimetil-sulfóxido, más diacetato de triamcinolona; en algunos, además, se practicó cirugía parcial. Los resultados son alentadores.


Subject(s)
Humans , Male , Female , Adult , Cicatrix , Keloid/drug therapy , Sulfoxides/therapeutic use , Triamcinolone Acetonide/therapeutic use , Drug Combinations , Mexico , Prospective Studies
20.
Egyptian Journal of Veterinary Science. 1984; 21 (2): 245-252
in English | IMEMR | ID: emr-4207

ABSTRACT

Comparative study of the effects of levomepromazine [LM] and its sulfoxide [LMSO] in relation to chlorpromazine [cpz] on animal's behaviour; namely the learned conditioned behaviour, was done in adult albino rats of both sexes. The results obtained in the present study revealed that the three test drugs at various sublethal dose levels were effective in blocking conditioned avoidance response [CAR], unconditioned escape response [UER] and secondary conditioning [SCR]. However LMSO was the least potent compound while M was the most potent in this respect. Thus it is concluded from the present results that sulfoxidation of the parent phenothiazine compound lead to marked decrease in the potency of the compound


Subject(s)
Sulfoxides , Animals, Laboratory , Behaviorism , Comparative Study
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