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1.
Dermatol. argent ; 27(1): 25-27, ene.-mar. 2021. il
Article in Spanish | LILACS, BINACIS | ID: biblio-1361643

ABSTRACT

La dermatosis IgA lineal del adulto es una enfermedad que pertenece al grupo de las dermatosis ampollares adquiridas. De etiología desconocida e infrecuente, se presenta en adultos mayores y se asocia a múltiples fármacos, neoplasias y enfermedades autoinmunes e infecciosas. Se presenta el caso de un paciente con una dermatosis IgA lineal asociada a una sífilis secundaria.


Linear bullous IgA dermatosis of adult is a disease that belongs to the group of acquired bullous dermatoses. It is of unknown aetiology and infrequent in adults and is associated with drugs, neoplasms, autoimmune and infectious diseases. We present a case of a male patient in whom a linear IgA dermatosis and secondary syphilis coexist.


Subject(s)
Humans , Male , Adult , Syphilis/complications , Linear IgA Bullous Dermatosis/drug therapy , Penicillin G Benzathine/administration & dosage , Syphilis Serodiagnosis , Dapsone/administration & dosage , Linear IgA Bullous Dermatosis/diagnosis
2.
Arq. neuropsiquiatr ; 79(2): 103-106, Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1153159

ABSTRACT

ABSTRACT Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). Methods: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients were classified according to the ASCOD phenotyping as SVD — when SVD was the potential causal mechanism (S1) — or non-SVD — when SVD was uncertain (S2), unlike (S3), or not detected (S0). Results: Syphilis was positive in 32 (12%) patients. When comparing patients with positive and negative serology, the only significant difference was SVD as the causal mechanism (S1) in patients with positive results: 9 (28%) vs. 22 (9%), p<0.01. Conclusion: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis.


RESUMO Introdução: A sífilis é uma doença endêmica, especialmente em países de baixa e média renda, com acometimento vascular descrito em grandes vasos (aortite), porém nenhuma relação clara foi reconhecida em paciente com acidente vascular cerebral, exceto para aqueles com sífilis meningovascular. Objetivos: Investigar a relação entre história positiva de sífilis determinada pelo status sorológico e o mecanismo do acidente vascular cerebral isquêmico, particularmente doença de pequenos vasos. Métodos: Ao todo, 269 pacientes com AVC isquêmico foram testados para sífilis. Pacientes com diagnóstico de neurossífilis foram excluídos. Todos os pacientes foram classificados segundo o fenótipo ASCOD quando a doença de pequenos vasos era o mecanismo causal provável (S1) ou não-pequenos vasos quando este mecanismo era incerto (S2), pouco provável (S3) ou não detectado (S0). Resultados: O teste para sífilis foi positivo em 32 (12%) pacientes. Quando comparados, pacientes com sorologia positiva e o grupo com teste não reagente, a única diferença significativa foi a doença de pequenos vasos como mecanismo causal (S1) em pacientes com sorologia positiva: 9 (28%) vs. 22 (9%), p<0.01. Conclusão: O presente estudo mostra que o teste sorológico positivo para sífilis tem maior ocorrência em pacientes com o primeiro AVC isquêmico com a doença de pequenos vasos como um mecanismo causal possível. Tal achado pode estar relacionado à disfunção endotelial que ocorre durante a sífilis.


Subject(s)
Humans , Syphilis/complications , Syphilis/epidemiology , Brain Ischemia/complications , Stroke , Ischemic Stroke , Syphilis Serodiagnosis
3.
Article in English | LILACS, BBO | ID: biblio-1252105

ABSTRACT

ABSTRACT OBJECTIVE: To analyze the factors associated with prematurity in reported cases of congenital syphilis in the city of Fortaleza, Ceará, Brazil. METHODS: Cross-sectional study conducted in ten public maternity hospitals in Fortaleza, Ceará, Brazil. A total of 478 reported cases of congenital syphilis were included in 2015, and data were collected from notification forms, from mothers' and babies' medical records and from prenatal cards. For the bivariate analysis, Pearson's chi-squared and Fisher's exact tests were used, considering p < 0.05. Multiple logistic regression was conducted, presenting odds ratio (OR) with a 95% confidence interval. RESULTS: We found 15.3% prematurity in pregnant women with syphilis. The titration of the VDRL test > 1:8 at delivery (OR 2.46; 95%CI: 1.33-4.53; p = 0.004) and the non-treatment of the pregnant women or treatment with drugs other than penicillin during prenatal care (OR 3.52; 95%CI: 1.74-7.13; p< 0.001) were associated with higher chances of prematurity. CONCLUSION: The prematurity due to congenital syphilis is a preventable condition, provided that pregnant women with syphilis are treated appropriately. Weaknesses in prenatal care are associated with this outcome, which highlights the importance of public policies oriented to improve the quality of prenatal care.


RESUMO OBJETIVO: Analisar os fatores associados à prematuridade em casos notificados de sífilis congênita no município de Fortaleza, Ceará, Brasil. MÉTODOS: Estudo transversal realizado em dez maternidades públicas de Fortaleza, Ceará, Brasil. Foram incluídos 478 casos notificados de sífilis congênita em 2015, e os dados foram coletados das fichas de notificação, dos prontuários das mães e dos bebês e do cartão de pré-natal. Para a análise bivariada, foram utilizados os testes do qui-quadrado de Pearson e exato de Fisher, considerando p < 0,05. Realizou-se regressão logística múltipla, apresentando razão de chances (OR) com intervalo de confiança de 95%. RESULTADOS: Encontrou-se 15,3% de prematuridade em gestantes com sífilis. A titulação do teste VDRL > 1:8 no parto (OR 2,46; IC95%: 1,33-4,53; p = 0,004), o não tratamento da gestante ou tratamento realizado com drogas diferentes da penicilina durante o pré-natal (OR 3,52; IC95%: 1,74-7,13; p < 0,001) estiveram associados a maiores chances de prematuridade. CONCLUSÃO: A prematuridade decorrente da sífilis congênita é um agravo evitável, desde que as gestantes com sífilis sejam tratadas adequadamente. As fragilidades na assistência pré-natal estão associadas a este desfecho, o que ressalta a importância de implementar políticas públicas voltadas a melhorar a qualidade do pré-natal.


Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Syphilis, Congenital/epidemiology , Syphilis/complications , Syphilis/epidemiology , Prenatal Care , Brazil/epidemiology , Cross-Sectional Studies
4.
Rev. bras. oftalmol ; 80(4): e0025, 2021. graf
Article in English | LILACS | ID: biblio-1288629

ABSTRACT

ABSTRACT Syphilis is a sexually transmitted infection caused by the spirochete Treponema pallidum. Ocular involvement can occur at any time, and it may affect 10% of patients in the secondary stage, and from 2% to 5% in the tertiary stage. Uveitis is the most common presentation of ocular syphilis, affecting 0.4% to 8% of patients with systemic disease. Chorioretinitis is the most common posterior alteration. We present the case of a 53-year-old male patient, presenting with bilateral low visual acuity and nyctalopia for 3 years. His physical examination revealed decreased pupillary reflex, anterior vitreous cells, physiologic papillae, arteriolar attenuation, reduced foveal reflex, diffuse retinal pigment epithelium atrophy, peripapillary and perivascular punctate pigment accumulation and peripheral chorioretinitis. Full-field electroretinogram was extinct in both eyes. Treponemal syphilis test was positive. Previously diagnosed as retinitis pigmentosa, evolved to blindness, despite proper treatment. Our case shows syphilis as a significant cause of blindness. Atypical presentations of retinitis pigmentosa must warn ophthalmologists to etiologies of pseudoretinitis pigmentosa, such as syphilis.


RESUMO A sífilis é uma infecção sexualmente transmissível causada pela espiroqueta Treponema pallidum. A sífilis ocular pode ocorrer em qualquer estágio da doença, chegando a 10% na forma secundária e a 2% a 5% em sua forma terciária. A uveíte é a manifestação ocular mais comum, ocorrendo em 0,4% a 8% dos pacientes com a doença sistêmica. A coriorretinite é a manifestação mais comum do segmento posterior. Apresentamos o caso de um paciente do sexo masculino, 53 anos, com queixa de baixa acuidade visual e nictalopia há ٣ anos. Seu exame físico revelou lentificação dos reflexos pupilares, celularidade no vítreo anterior, papilas fisiológicas, atenuação arteriolar, redução do reflexo foveal, atrofia difusa do epitélio pigmentar da retina, acúmulo punctato de pigmento em regiões peripapilar e perivascular e coriorretinite periférica. Eletrorretinograma de campo total extinto em ambos os olhos. O teste treponêmico foi positivo. Foi previamente diagnosticado como portador de retinose pigmentar, evoluindo com cegueira, a despeito do tratamento correto instituído. Esse caso mostra a sífilis como importante causadora de cegueira. Casos atípicos de retinose pigmentar devem alertar o oftalmologista para causas de pseudorretinose pigmentar, como a sífilis.


Subject(s)
Humans , Male , Middle Aged , Retinal Diseases/etiology , Syphilis/complications , Retinitis Pigmentosa/etiology , Retinal Diseases/diagnosis , Ceftriaxone/therapeutic use , Syphilis Serodiagnosis/methods , Fluorescein Angiography , Syphilis/diagnosis , Syphilis/drug therapy , Visual Acuity , Uveitis, Posterior/diagnosis , Uveitis, Posterior/etiology , Retinitis Pigmentosa/diagnosis , Blindness/etiology , Tomography, Optical Coherence , Electroretinography , Fundus Oculi
5.
Medicina (B.Aires) ; 80(6): 714-717, dic. 2020. graf
Article in Spanish | LILACS | ID: biblio-1250300

ABSTRACT

Resumen La sífilis maligna asociada al virus de la inmunodeficiencia humana (HIV). Se presenta con lesiones nodulares cutáneas con tendencia a la ulceración. Entre sus hallazgos histopatológicos se destaca la presencia de granulomas no caseificantes, lo cual obliga al diagnóstico diferencial con otras patologías granulomatosas infecciosas y no infecciosas. La evolución de la enfermedad es favorable con el tratamiento con penicilina en la mayoría de los casos. Presentamos el caso de una paciente con infección por HIV que cumple criterios diagnósticos de sífilis maligna y alertamos sobre esta entidad granulomatosa poco frecuente.


Abstract Malignant syphilis occurs frequently in patients infected with human immunodeficiency virus (HIV) and presents with cutaneous nodular lesions that tend to ulcerate. Non caseating granulomas are among the most conspicuous histopathological findings and require differential diagnosis with other infectious and non-infectious granulomatous conditions. The evolution of the disease is usually favourable with penicillin treatment. We present the case of an HIV-positive patient who meets diagnostic criteria for malignant syphilis and alert on this infrequent granulomatous entity.


Subject(s)
Humans , Syphilis/complications , Syphilis/diagnosis , Syphilis/drug therapy , HIV Infections/complications , HIV Infections/diagnosis , Administration, Cutaneous , Diagnosis, Differential , Granuloma
6.
Femina ; 48(6): 359-362, 20200630. ilus
Article in Portuguese | LILACS | ID: biblio-1102817

ABSTRACT

De acordo com a Organização Mundial da Saúde, a cada ano, mais de 376 milhões de pessoas são infectadas pelas doenças sexualmente transmissíveis, das quais 127,2 milhões são por Chlamydia trachomatis. As infecções genitais não tratadas na gestação, principalmente as assintomáticas, podem acarretar complicações, tais como: endometrite puerperal e síndrome de Fitz-Hugh-Curtis. A pesquisa científica foi realizada com o objetivo de identificar a presença de Chlamydia trachomatis na secreção endocervical de gestantes sifilíticas, estabelecendo o perfil das gestantes a partir de informações dos possíveis sinais e sintomas durante a gravidez e hábitos gestacionais. Adotou-se como caminho metodológico a pesquisa quantitativa, descritiva, bibliográfica e laboratorial. Como resultados finais, 54% das gestantes foram diagnosticadas com Chlamydia trachomatis e 67% eram assintomáticas. Correlacionamos também que as altas taxas de infecção estão associadas com a falta de conhecimento sobre infecções sexualmente transmissíveis e suas formas de prevenção.(AU)


According to the World Health Organization, each year, more than 376 million people are infected with sexually transmitted diseases, of which 127.2 million are Chlamydia trachomatis, it is a asymptomatic disease, meaning there are no symptoms. Genital infections can lead to complications such as: puerperal endometritis and Fitz-Hugh- -Curtis syndrome. The scientific research was carried out to identify the presence of Chlamydia trachomatis in the endocervical secretion of syphilitic pregnant women. This research established a profile of pregnant women infected with Chlamydia trachomatis using information about possible signs and symptoms during pregnancy and gestational habits. It provides a methodological way to quantify and describe the laboratory research. The results showed, 54% of the pregnant women were diagnosed with Chlamydia trachomatis of which 67% were asymptomatic. We also correlate that high rates of Chlamydia trachomatis infection are associated with lack of knowledge about sexually transmitted infections and their forms of prevention.(AU)


Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications , Chlamydia Infections/complications , Chlamydia Infections/epidemiology , Syphilis/complications , Chlamydia trachomatis/pathogenicity , Brazil/epidemiology , Sexually Transmitted Diseases/complications , Comorbidity
7.
Rev. méd. Chile ; 148(3): 344-348, mar. 2020. tab, graf
Article in English | LILACS | ID: biblio-1115798

ABSTRACT

ABSTRACT Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. Penicillin (PNC) is the only effective antimicrobial for the treatment of pregnant women with syphilis. Chilean guidelines do not consider desensitization to PNC in these women. We report two cases of pregnant women aged 32 and 23 years, with immediate allergy to PNC and syphilis who were safely and successfully desensitized using a four-hour intravenous protocol in the critical care unit and who subsequently received benzathine G PNC. An electronic survey was conducted among approximately 100 Clinical Pharmacists (CP) in the country. Of these, 16 answered and 13 reported having experience in drug desensitization, in at least five cases with PNC and none reported deaths or cardiorespiratory arrest. Desensitization to PNC can be carried out safely and in Chile, this alternative should be incorporated to the management of pregnant women with syphilis and immediate allergy to PNC, instead of using erythromycin.


La sífilis durante el embarazo tiene un alto riesgo de transmisión congénita con consecuencias desastrosas para el feto. La penicilina (PNC) es el único compuesto efectivo para el tratamiento de sífilis en una mujer embarazada.. En Chile, ante alergias de tipo inmediata, no se considera la desensibilización a la PNC en mujeres embarazadas por norma ministerial. Se comunican dos casos de mujeres embarazadas con alergia tipo inmediata y sífilis durante la gestación que fueron desensibilizadas a este compuesto con un protocolo endovenoso de 4 horas en la unidad de pacientes críticos, sin observar complicaciones, recibiendo posteriormente PNC G Benzatina. Se efectuó una encuesta electrónica a farmacéuticos clínicos del país que incluyó más de 100 profesionales. De ellos, 16 contestaron y 13 declararon poseer experiencia en desensibilización de fármacos, en al menos cinco casos con PNC y ninguno reportó muertes o paro cardiorrespiratorio. La desensibilización a PNC puede ser efectuada en forma segura en embarazadas con alergia de tipo inmediata a PNC que cursan con sífilis. En Chile se debería incorporar esta alternativa en el manejo de mujeres embarazadas con sífilis y alergia inmediata a PNC en lugar de solo considerar por norma el uso de eritromicina.


Subject(s)
Humans , Male , Pregnancy , Adult , Young Adult , Pregnancy Complications, Infectious , Syphilis/complications , Hypersensitivity/complications , Penicillin G Benzathine , Chile
8.
Buenos Aires; ASAPER; 2020. 216 p. ilus, graf.(Clínicas Perinatológicas Argentinas, 2019-2020).
Monography in Spanish | LILACS, InstitutionalDB, BINACIS, UNISALUD | ID: biblio-1342955

ABSTRACT

Número que reúne material del curso a distancia Clínicas Perinatológicas Argentinas 201-2020, desarrollado por la Asociación Argentina de Perinatología.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Perinatology/instrumentation , Perinatology/methods , Breast Feeding/trends , Pregnancy , Syphilis/complications , Perinatal Care , Perinatal Death , Postpartum Hemorrhage , Neonatology
9.
Article in English | LILACS | ID: biblio-1123230

ABSTRACT

Introduction: Syphilis and HIV infections are sexually transmitted infections whose diagnosis and treatment contribute toward preventing congenital transmission. Objective: To report a case of three sexually transmitted infections detected in a male partner during Couple Consultation and syphilis in the female partner during prenatal care. Case report: A 34-year-old black female G2P1 pregnant woman was referred to an outpatient clinic of sexually transmitted infections in Vitória, Brazil, reporting a 30-day evolution of painless papular lesions in the external genitalia, suggestive of condylomata lata. Nontreponemal tests were positive for syphilis and negative for HIV. The husband reported unprotected receptive anal intercourse and possessed anal condylomatous lesions and perianal condylomata lata. He was positive for both HIV and syphilis. Histopathological findings showed low-grade HPV lesions and the PCR test found 16, 39, and 53 HPV subtypes. Treatment with benzathine penicillin G was successful for both partners. Conclusion: This study emphasizes the need for Couple Consultation during pregnancy to identify and treat possible sexually transmitted infections.


Introdução: As infecções por sífilis e HIV são infecções sexualmente transmissíveis cujo diagnóstico e tratamento contribuem para a prevenção da transmissão congênita. Objetivo: Relatar um caso de três infecções sexualmente transmissíveis detectadas em um parceiro masculino durante a consulta do casal e sífilis na parceira durante o pré-natal. Relato de caso: Uma gestante, negra, G2P1, 34 anos, foi encaminhada a um ambulatório de infecções sexualmente transmissíveis em Vitória, Brasil, relatando uma evolução de 30 dias de lesões papulares indolores na genitália externa, sugestivas de condiloma lata. Os testes não treponêmicos foram positivos para sífilis e negativos para HIV. O marido relatou relação sexual anal receptiva desprotegida e possuía lesões condilomatosas anais e condiloma lata perianal. Ele testou positivo tanto para HIV quanto para sífilis. Os achados histopatológicos mostraram lesão de HPV de baixo grau e o teste de PCR encontrou subtipos de HPV 16, 39 e 53. O tratamento com penicilina benzatina G foi bem­sucedido em ambos os parceiros. Conclusão: Este estudo enfatiza a necessidade de consultas de casal durante a gravidez para identificar e tratar possíveis infecções sexualmente transmissíveis.


Subject(s)
Humans , Male , Female , Pregnancy , Adult , Sexually Transmitted Diseases/complications , Penicillin G Benzathine/therapeutic use , Prenatal Care , Bisexuality , Condylomata Acuminata/complications , Condylomata Acuminata/pathology , Condylomata Acuminata/drug therapy , Syphilis/complications , Syphilis/pathology , Syphilis/drug therapy , Sexually Transmitted Diseases/pathology , Sexually Transmitted Diseases/drug therapy , HIV Infections/complications , Squamous Intraepithelial Lesions/pathology , Anti-Bacterial Agents/therapeutic use
10.
Medicina (B.Aires) ; 79(5): 415-418, oct. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1056743

ABSTRACT

La sífilis es una enfermedad de transmisión sexual causada por una espiroqueta, Treponema palidum. Presentamos el caso de una mujer de 62 años de edad, que consultó por fiebre de 38°, dolor torácico en puntada de costado y lesiones pruriginosas en piel. Se realizó examen de laboratorio de sangre periférica, radiografía y tomografía de tórax. Recibió tratamiento antibiótico y fue diagnosticada como neumonía aguda de la comunidad. Debido a la respuesta parcial de los síntomas y persistencia de lesiones pruriginosas se realizó biopsia de piel que informó Treponema palidum, el cual fue confirmado con test serológico VDRL y FtA-abs positivo. La paciente recibió 4 dosis de penicilina G benzatínica con favorable evolución de las lesiones en piel y mejoría de las imágenes radiológicas.


We present the case of a 62-year-old woman who consulted for fever (38°), stabbing thoracic pain (on one side), and pruritic skin lesions. She underwent peripheral blood tests, chest X-rays and CT. Her symptoms were interpreted as severe community-acquired pneumonia. After a treatment with antibiotics, her skin lesions persisted, and other symptoms were only partially relieved. A skin biopsy was performed, which revealed Treponema pallidum. Such finding was confirmed through positive serum VDRL and FTA-ABS tests. The patient received 4 doses of benzathine penicillin G with favorable evolution of skin lesions and improvement of radiological images.


Subject(s)
Humans , Female , Middle Aged , Syphilis/complications , Lung Diseases/microbiology , Treponema pallidum/isolation & purification , Biopsy , Radiography, Thoracic , Syphilis/microbiology , Tomography, X-Ray Computed , Dermatitis/microbiology , Dermatitis/pathology , Lung Diseases/pathology , Lung Diseases/diagnostic imaging
12.
Rev. otorrinolaringol. cir. cabeza cuello ; 79(1): 105-109, mar. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1004390

ABSTRACT

RESUMEN La sífilis es una infección de transmisión sexual causada por la bacteria Treponema pallidum. En los últimos años ha habido un aumento en la incidencia de esta enfermedad debido a la creciente infección por el virus de la inmunodeficiencia humana (VIH) e inmunodepresión. Conocida como "la gran imitadora" son muchos los signos y síntomas que puede simular, siendo la presentación orofaríngea infrecuente. Presentamos el caso de un varón de 31 años de edad que acude a nuestro servicio por clínica de otitis media serosa bilateral. En la exploración física se objetiva una masa en cavum y una ulceración en pared faríngea posterior que se biopsia en consultas externas siendo el resultado un intenso infiltrado inflamatorio crónico de probable origen infeccioso, por lo que se decidió tomar una nueva biopsia bajo anestesia general. El día de la intervención, el paciente refirió la aparición de un exantema eritematoso generalizado, pero de predominio palmo-plantar. Interrogado sobre sus antecedentes, el paciente reconoció conductas sexuales de riesgo y ser portador VIH, por lo que se orientó el diagnóstico hacia una probable sífilis secundaria que se confirmó posteriormente mediante serología. Las lesiones de orofaringe, la masa del cavum y el exantema remitieron con tratamiento antibiótico y corticoideo pautado. Cuando las manifestaciones de cabeza y cuello constituyen la presentación inicial de la sífilis, su diagnóstico se retrasa con frecuencia debido al desconocimiento por parte del médico de primaria, e incluso del otorrinolaringólogo, de las formas típicas de presentación en esta localización. Su diagnóstico precoz es fundamental para prevenir la extensión de la enfermedad.


ABSTRACT Syphilis is a sexually transmitted infection caused by the bacteria Treponema pallidum. Over the last years there has been an increase of the incidence of this disease due to the growing infection by the human inmunodeficiency virus (HIV) and the inmunosupression. Known as "the great imitator", there are many signs and symptoms that can simulate, being the oropharyngeal presentation infrequent. We present the case of a 31-year-old man who came to our service for bilateral otitis media. Physical examination revealed a mass in the cavum and ulceration in the posterior pharyngeal wall that was biopsied in the outpatient clinic. The result was an intense chronic inflammatory infiltrate of probable infectious origin, so it was decided to take a new biopsy under general anesthesia. On the day of the intervention, the patient reported the appearance of a generalized erythematous rash, but predominantly on the bottoms of the feet and on the palms of the hands. Questioned about his background, the patient recognized risky sexual behavior and being an HIV carrier, so the diagnosis was oriented towards a probable secondary syphilis that was subsequently confirmed by serology. The ulcerations of the oropharynx, the mass of the cavum and the rash subsided with antibiotic treatment and corticoid regimen. When the manifestations of the head and neck are the initial presentation of syphilis, its diagnosis is often delayed due to the lack of knowledge of the physicians of the typical presentation forms in this location. Early diagnosis is essential to prevent the spread of the disease and its complications.


Subject(s)
Humans , Male , Adult , Syphilis/complications , Oral Ulcer/etiology , Otitis Media , Penicillins/therapeutic use , Treponema pallidum , Syphilis/diagnosis , Syphilis/microbiology , Oral Ulcer/microbiology , Erythema/etiology
13.
Rev. Soc. Bras. Med. Trop ; 52: e20190044, 2019. tab, graf
Article in English | LILACS | ID: biblio-1041568

ABSTRACT

Abstract We present a case of atypical presentation of secondary syphilis with extensive lymph node involvement and pulmonary lesions, initially suspected as lymphoma. The patient presented with weight loss, dry cough, chest pain, palpable lymph nodes in several peripheral chains, and multiple pulmonary nodules and masses on chest imaging. The key features for secondary syphilis diagnosis were a lymph node biopsy suggestive of reactive lymphadenopathy, positive serologic tests for syphilis, and complete recovery after antisyphilitic treatment.


Subject(s)
Humans , Male , Syphilis/diagnosis , Lymphadenopathy/diagnosis , Lung Diseases/diagnosis , Lymphoma/diagnosis , Biopsy , Syphilis/complications , Tomography, X-Ray Computed , Diagnosis, Differential , Lymphadenopathy/microbiology , Lung Diseases/microbiology
14.
Hist. ciênc. saúde-Manguinhos ; 25(4): 921-941, Oct.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-975433

ABSTRACT

Abstract This article explores women's reproductive health in early twentieth-century Rio de Janeiro, showing that elevated and sustained stillbirth and maternal mortality rates marked women's reproductive years. Syphilis and obstetric complications during childbirth were the main causes of stillbirths, while puerperal fever led maternal death rates. Utilizing traditional sources such as medical dissertations and lesser-used sources including criminal investigations, this article argues that despite official efforts to medicalize childbirth and increase access to clinical healthcare, no real improvements were made to women's reproductive health in the first half of the twentieth century. This, of course, did not make pregnancy and childbirth any easier for the women who embodied these statistics in their reproductive lives.


Resumo O artigo aborda a saúde reprodutiva das mulheres no Rio de Janeiro do início do século XX, mostrando que taxas elevadas de mortalidade materna e de contínua natimortalidade marcavam os anos reprodutivos das mulheres. As principais causas de natimortalidade eram sífilis e complicações obstétricas, enquanto febre puerperal encabeçava as taxas de morte materna. Utilizando fontes tradicionais como teses doutorais e fontes como investigações criminais, o artigo discute que, apesar dos esforços oficiais para medicalizar o parto e aumentar o acesso aos serviços de saúde, nenhuma melhoria real foi feita na saúde reprodutiva das mulheres na primeira metade do século XX. Isso, certamente, não facilitou a gravidez e o parto das mulheres que compunham as estatísticas em suas vidas reprodutivas.


Subject(s)
Humans , Female , Pregnancy , History, 20th Century , Maternal Mortality/history , Women's Health/history , Delivery, Obstetric/history , Stillbirth , Reproductive Health/history , Pregnancy Complications, Infectious/history , Puerperal Infection/history , Brazil , Syphilis/complications , Syphilis/history , Cities , Delivery, Obstetric/adverse effects
15.
Medisan ; 22(8)set.-oct. 2018. ilus
Article in Spanish | LILACS | ID: biblio-976160

ABSTRACT

Se describe el caso clínico de una paciente de 38 años de edad, quien fue atendida en la consulta estomatológica del Policlínico Cuatro Caminos, por presentar múltiples lesiones indoloras en casi toda la mucosa bucal. Teniendo en cuenta estos síntomas se le diagnosticó una estomatitis aftosa recurrente, pero el tratamiento indicado no resultó satisfactorio. Luego se interconsultó con el especialista en Medicina Interna, quien le indicó exámenes complementarios y, según los criterios clínicos y de laboratorio, se confirmó la presencia de sífilis secundaria. Se efectuó el control de foco y se logró la remisión de la enfermedad.


The case report of a 38 year-old patient who was assisted in the stomatological department of Cuatro caminos polyclinic is described due to multiple painless lesions in almost all the oral mucous. Keeping in mind these symptoms a recurrent aphthous stomatitis was diagnosed, but the prescribed treatment was not satisfactory. Then a consultation with the specialist in Internal Medicine was carried out, who indicated her complementary exams and, according to the clinical and laboratory criteria, the presence of secondary syphilis was confirmed. The focus control was carried out and the remission of the disease was achieved.


Subject(s)
Humans , Male , Adult , Oral Manifestations , Syphilis/complications , Primary Health Care , Mouth Mucosa/injuries
16.
Medicina (B.Aires) ; 78(4): 286-289, ago. 2018. tab
Article in Spanish | LILACS | ID: biblio-954996

ABSTRACT

La polineuropatía desmielinizante inflamatoria crónica (PDIC) se presenta generalmente con síntomas motores, debilidad tanto en los músculos proximales como en los distales con reflejos globalmente disminuidos o ausentes. La neuritis insulínica es un trastorno caracterizado por dolor agudo de las extremidades, y daño de los nervios periféricos con afectación predominante de las fibras pequeñas, en los pacientes diabéticos sometidos a un rápido control glucémico. El dolor es raro en la PDIC clásica. Describimos el caso de una mujer de 54 años con diabetes mellitus (DB) tipo II, en tratamiento reciente con insulina, que consultó por un cuadro de debilidad e hiperalgesia de los cuatro miembros de dos meses de evolución. Al examen físico presentaba dolor de intensidad 10/10 y alodinia en los cuatro miembros, a niveles proximal y distal, con fuerza muscular reducida de los músculos proximales y arreflexia patelar y aquilea bilateral. Se realizó un estudio electrofisiológico, el cual mostró una polineuropatía sensitiva y motora desmielinizante. Se indicó tratamiento con inmunoglobina humana recombinante, con total remisión del cuadro. Estudios realizados posteriormente demostraron positividad débil de los anticuerpos GM1, GD1a, GD1b y anti-asialo GM1. Previo al alta hospitalaria se recibieron los resultados de VDRL sérica positiva, y FTA-Abs. VDRL en líquido cefalorraquídeo fue negativa por lo que se descartó neurosífilis, indicándose tratamiento con penicilina benzatínica.


Chronic inflammatory demyelinating polyneuropathy (CIDP) is a disorder characterized by motor symptoms such as weakness in both proximal and distal muscles with globally diminished or absent reflexes. Insulin neuritis is referred as an acute pain in the extremities, due to the damage of peripheral nerves affecting mainly small fibers, in diabetic patients treated with insulin who achieved rapid glycemic control. Pain is unusual in classic CIDP. We report the case of a 54-year-old female patient with type II diabetes mellitus, and a recent onset of insulin therapy, who presented at the emergency room with a 2-month history of weakness and hyperalgesia of extremities. Physical examination showed marked pain and proximal and distal allodynia in the 4 limbs, with reduced muscle strength of the proximal muscles and patellar and achillear areflexia. Electrophysiological study showed sensory and motor polyneuropathy with a demyelinating predominance. Treatment with recombinant human immunoglobin was started, and the patient presented a total remission of the condition. Complementary studies confirmed weak serum positivity of GM1, GD1a, GD1b and anti-asialo GM1. Prior to hospital discharge, results of positive serum VDRL and FTA-Abs were received. VDRL in cerebrospinal fluid was negative, so neurosyphilis was ruled out, and treatment with benzathine penicillin was indicated.


Subject(s)
Humans , Female , Middle Aged , Syphilis/complications , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/chemically induced , Diabetes Mellitus, Type 2/drug therapy , Hypoglycemic Agents/adverse effects , Insulin/adverse effects , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis , Diabetes Mellitus, Type 2/complications , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage
17.
An. bras. dermatol ; 93(4): 590-591, July-Aug. 2018. graf
Article in English | LILACS | ID: biblio-949935

ABSTRACT

Abstract: Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum subspecies pallidum. Its association with other STIs, including HIV, demands early diagnosis and immediate treatment of patients. We herein report an unusual serpiginous form of secondary syphilis.


Subject(s)
Humans , Male , Adult , Syphilis/complications , Foot Dermatoses/etiology , Hand Dermatoses/etiology , Penicillin G Benzathine/administration & dosage , Syphilis/diagnosis , Syphilis/drug therapy , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Injections, Intramuscular , Anti-Bacterial Agents/administration & dosage
18.
An. bras. dermatol ; 93(1): 129-132, Jan.-Feb. 2018. graf
Article in English | LILACS | ID: biblio-887149

ABSTRACT

Abstract: Secondary syphilis can have different clinical presentations, with corymbiform rash as its rarest manifestation. The disease is characterized by a central papule surrounded by smaller ones. We report the case of a man who has sex with man with corymbiform syphilis. The patient was subsequently diagnosed with HIV infection, hepatitis B, non-gonococcal urethritis, as well as infection of the central nervous system by treponema. This case not only illustrates a rare presentation of secondary syphilis, but also demonstrates the importance of further investigation of sexually transmitted infections, particularly among at-risk patients.


Subject(s)
Humans , Male , Adult , Syphilis/diagnosis , Sexually Transmitted Diseases/diagnosis , Patient Dropouts , Urethritis/complications , Urethritis/diagnosis , Syphilis/complications , Syphilis/therapy , Sexually Transmitted Diseases/complications , Sexually Transmitted Diseases/therapy , HIV Infections/complications , HIV Infections/diagnosis , Risk Factors , Hepatitis B/complications , Hepatitis B/diagnosis , Anti-Bacterial Agents/therapeutic use
19.
Rev. medica electron ; 39(3): 567-576, may.-jun. 2017.
Article in Spanish | LILACS, CUMED | ID: biblio-902200

ABSTRACT

La sífilis gestacional se transmite de madre a hijo, por vía placentaria y por canal del parto. Es diagnosticada en el niño en el momento del nacimiento, esta transmisión hematógena del treponema pallidum de la gestante no tratada o tratada inadecuadamente a su recién nacido, se denomina sífilis congénita. Entre las estrategias del Ministerio de Salud Pública está prevenir la transmisión materna de la sífilis al feto, o al menos, tratarla en útero. Para lograr este propósito debe garantizarse la realización de serologías a la gestante y al esposo. Múltiples pueden ser las causas de una serología reactiva pero siempre se debe pensar en la sífilis. Se presentan tres casos de sífilis en gestantes y su seguimiento en área de salud (AU).


Gestational syphilis is transmitted from mother to child via the placenta and the birth canal. It is diagnosed in the child at the moment of birth. This hematogenous transmission of the treponema pallidum from the non-treated or inadequately treated pregnant woman to her new born child is called congenital syphilis. Preventing the maternal transmission of the syphilis to the fetus, or at least treating it in the uterus, is among the strategies of the Ministry of Public Health. To achieve this purpose serology should be carried out to the pregnant woman and her husband. The causes of a reactive serology might be different, but it is always necessary to thing of syphilis. Three cases of syphilis in pregnant women are presented and also their follow-up in a health area (AU).


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Syphilis, Congenital/complications , Pregnancy/genetics , Syphilis/epidemiology , Syphilis, Congenital/diagnosis , Syphilis, Congenital/therapy , Syphilis, Congenital/transmission , Syphilis, Congenital/epidemiology , Syphilis/complications , Syphilis/genetics , Syphilis/transmission
20.
Nursing (Säo Paulo) ; 20(224): 1556-1560, jan.2017.
Article in Portuguese | LILACS, BDENF | ID: biblio-869185

ABSTRACT

Sífilis é uma doença infecciosa crônica, causada pelo Treponema Pallidum, com transmissão predominantemente sexual,podendo ocorrer por via transplacentária, causando grande morbidade na vida intra uterina com desfechos negativos na gestação. Objetivo:Compreender o conhecimento das puérperas sobre Sífilis e Sífilis congênita. Método: Trata-se de uma pesquisa qualitativa exploratória descritiva com puérperas, maiores de 18 anos, com resultado positivo para Sífilis. O cenário de pesquisa foi o Alojamento Conjunto de uma maternidade na Baixada Fluminense do Estado do Rio de Janeiro, após autorização do Comitê de Ética da Secretaria Municipal de SaúdeRJ, CAAE 5545016.30000.5279 Resultados e Discussão: Foram quinze jovens puérperas, com baixa escolaridade, oito descobriram serem portadoras de sífilis no pré-natal, seis na maternidade e duas na gravidez anterior, e somente duas, tiveram seu parceiro tratado, o que desafia a equipe de saúde para implementação de estratégias que visem diagnóstico e tratamento precoce das gestantes e de seus parceiros, apresentam conhecimento superficial da Sifilis e não compreendem o que significa congênito. Conclusão: despreocupação aparente dessas mulheres e dos seus parceiros em relação aos seus filhos expostos à sífilis, refere-se à falta de informação adequada sobre a doença. A participação do parceiro no pré-natal deve ser estimulada pela equipe da unidade de saúde, visto que o problema envolve toda a família. Algumas puérperas se culpam pelo sofrimento do filho, e os profissionais de saúde precisam desenvolver habilidades para apoiá-las,não aplicando juízo de valor quanto à responsabilização na transmissão da doença.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Prenatal Care , Risk Factors , Maternal and Child Health , Maternal Health Services , Syphilis/complications , Syphilis/diagnosis , Syphilis/prevention & control , Syphilis/transmission , Socioeconomic Factors
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