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1.
Arch. argent. pediatr ; 120(1): e43-e48, feb 2022. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1353825

ABSTRACT

La encefalitis por anticuerpos contra el receptor N-metilD-aspartato es un proceso inmunomediado en el que autoanticuerpos se dirigen contra la subunidad GluN1 del receptor de glutamato del sistema nervioso central. Se caracteriza por la aparición aguda o subaguda de síntomas psiquiátricos, como confusión, pérdida de la memoria a corto plazo, cambios de conducta, catatonía, seguidos por manifestaciones neurológicas, tales como convulsiones, alteraciones del movimiento, disfunciones autonómicas, coma y depresión respiratoria. Es grave y potencialmente mortal. Su asociación con teratoma de ovario como síndrome paraneoplásico fue descrita en mujeres jóvenes. En la población pediátrica, es mucho menos frecuente y se reporta en comunicaciones de 1 o 2 pacientes y en series de pocos casos. Se presenta una paciente de 13 años con encefalitis paraneoplásica por anticuerpos contra el receptor N-metil-Daspartato, secundaria a un teratoma ovárico maduro.


The encephalitis due to antibodies against the N-methylD-aspartate receptor is a process immune-mediated in which antibodies are directed against the GluN1 subunit of the glutamate receptor in the central nervous system. It is characterized by an acute or subacute onset of psychiatric symptoms such as confusion, short-term memory loss, behavioral changes, catatonia followed by neurological manifestations such as seizures, movement disturbances, autonomic dysfunctions, coma, and respiratory depression. It is serious and life threatening. Its association with ovarian teratoma as a paraneoplastic syndrome was described in youngwomen. In the pediatric population it is much less frequent and is reported in publications of one or two patients and in series of few cases. We present a 13-year-old patient with encephalitis paraneoplastic due to antibodies against the N-methyl-Daspartate receptor, secondary to a mature ovarian teratoma.


Subject(s)
Humans , Female , Adolescent , Ovarian Neoplasms/complications , Ovarian Neoplasms/diagnosis , Teratoma/complications , Teratoma/diagnosis , Encephalitis , Autoantibodies , Receptors, N-Methyl-D-Aspartate
2.
Autops. Case Rep ; 12: e2021347, 2022. graf
Article in English | LILACS | ID: biblio-1355724

ABSTRACT

Fetus in fetu (FIF) is a rare entity in which a malformed vertebrate fetus is incorporated within its twin. This entity should be differentiated from a teratoma, which has more malignant potential. We describe a neonate with a heterogeneous calcified suprarenal mass. The aspiration cytology revealed a heterogeneous cell population with spindle cells and small round blue cells. Operative and histopathologic examination showed features consistent with a fetus in fetu. This case report describes a rare entity and discusses its clinical presentation, cytological features on fine-needle aspiration, and the difficulties posed in its differentiation from a teratoma.


Subject(s)
Humans , Female , Infant, Newborn , Teratoma/complications , Adrenal Glands , Biopsy, Fine-Needle , Fetus/abnormalities , Congenital Abnormalities/pathology
4.
Autops. Case Rep ; 8(2): e2018019, Apr.-May 2018. ilus
Article in English | LILACS | ID: biblio-905584

ABSTRACT

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a recently described auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations affecting young adults with ovarian teratoma. The availability of a novel assay to measure these antibodies might suggest an etiology for this potentially life-threatening disease, which if early recognized can be treated promptly with surgery with chances of a good clinical outcome. Reported prognostic indicators for a good outcome depend on the presence of a tumor, prompt treatment and no admission to an intensive care unit. However, due to the rarity and unawareness of this disease, the diagnosis may be delayed as primary psychiatric disorders, and infective encephalitis is taken more into consideration and ruled out first. Here we report a case of anti-NMDAR encephalitis in a 22-year-old female prompted by an ovarian teratoma with a gradual and complete resolution of symptoms after surgical excision of the teratoma and immunomodulating therapies.


Subject(s)
Humans , Female , Adult , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications , Ovarian Neoplasms/complications , Teratoma/complications , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis
5.
Rev. chil. pediatr ; 89(3): 373-379, jun. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-959536

ABSTRACT

INTRODUCCIÓN: Entre las causas de pubertad precoz periférica en el varón están los tumores secretores de betagonadotrofina coriónica humana (Β-HCG), como hepatoblastomas, disgerminomas, corio-carcinomas y teratomas inmaduros. En pediatría los teratomas mediastínicos son raros, representan el 7-10% de los teratomas extragonadales. OBJETIVO: Describir caso de un paciente que cursa con pubertad precoz periférica debida a teratoma tímico secretor de Β-HCG. CASO CLÍNICO: Escolar masculino de 7 años 10 meses consultó por cuadro de 3 meses de cambios de la voz, ginecomastia, aparición de vello pubiano y aumento de volumen genital. En exámenes destacaba edad ósea de 9 años, testosterona total 9,33ng/ml (< 0,4ng/ml), dehidroepiandrosterona sulfato (DHEAS), 17-hidroxi-progesterona (17-OH-P) y prueba de hormona adrenocorticotrofina (ACTH) normales, hormona luteinizante (LH) y hormona folículo estimulante (FSH) basales bajas, Β-HCG 39,5mU/ml (< 2,5 mUI/ml), alfa fetoproteína (α-FP) 11,2ng/ml (0,6-2,0 ng/ml). Estudio de imágenes para determinar origen de secreción de Β-HCG incluye: ecografía testicular y tomografla axial computarizada (TAC) torácica, abdominal y pelviana normales; resonancia cerebral y selar sin hallazgos significativos. Tomografía por emisión de positrones/tomografía computada (PET SCAN) evidenció imagen de tumor en mediastino antero-superior. Se resecó el tumor, cuya biopsia evidenció teratoma quístico inmaduro en timo. Evolución postoperatoria fue satisfactoria, con normalización de niveles hormonales. CONCLUSIÓN: La presentación de un teratoma en paciente pediátrico es infrecuente, aún más, si es inmaduro, su localización es tímica y es secretor de Β-HCG. Es relevante considerarlo dentro de diagnósticos diferenciales frente a pubertad precoz, de modo que pueda efectuarse un manejo oportuno.


INTRODUCTION: Among the causes of peripheral precocious puberty in men are the beta- human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas. OBJECTIVE: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. CLINICAL CASE: A seven-years-old schoolboy presents a three-months history of voice changes, gynecomastia, pubic hair appearance, and increased genital volume. In the exams, bone age of nine years, total testosterone 9.33ng/ml (< 0.4ng/ml), dehydroepiandrosterone sulfate (DHEAS), 17-hydroxyprogesterone (17-OHP), and normal adrenocorticotropic hormone (ACTH) test stand out; luteinizing hormone (LH) and follicle stimulating hormone (FSH) with low basal levels, P-HCG 39.5mU/ml (< 2.5 mUI/ml), alpha feto protein (Α-FP) 11,2ng/ml (0.6-2.0 ng/ml). Imaging study to determine the origin of P-HCG secretion shows normal testicular ultrasound and thoracic, abdominal, and pelvic computerized axial tomo graphy (CAT); brain and sellar resonance without significant findings. The positron emission tomography/computed scan (PET SCAN) shows a tumor image in the anterosuperior mediastinum. The tumor is resected, and the biopsy shows an immature cystic teratoma in the thymus. Post-operatory evolution was satisfactory, with normalization of hormonal levels. CONCLUSION: The appearance of a teratoma in a pediatric patient is rare, even more if it is immature, with thymic location and Β-HCG- secretor. It is important to consider it within the differential diagnosis facing precocious puberty, as a better way to handle appropriately.


Subject(s)
Humans , Male , Child , Puberty, Precocious/etiology , Teratoma/diagnosis , Thymus Neoplasms/diagnosis , Chorionic Gonadotropin, beta Subunit, Human/metabolism , Puberty, Precocious/diagnosis , Teratoma/complications , Teratoma/metabolism , Thymus Neoplasms/complications , Thymus Neoplasms/metabolism
6.
Autops. Case Rep ; 8(1): e2018004, Jan.-Mar. 2018. ilus, tab
Article in English | LILACS | ID: biblio-905425

ABSTRACT

Teratomas are one of the most frequent tumors in the pediatric population. They occur anywhere along the midline of the body, following the course of the embryonic germ cell ridge. In the mediastinal location, they exert space occupying effects, leading to a myriad of complications, including non-immune hydrops fetalis. We describe a fatal case of an immature thymic teratoma in a neonate presenting with hydrops fetalis. This case emphasizes the importance of early diagnosis and surgical intervention in such cases.


Subject(s)
Humans , Male , Infant, Newborn , Hydrops Fetalis/diagnosis , Mediastinal Neoplasms/complications , Teratoma/complications , Autopsy , Erythroblastosis, Fetal/diagnosis , Fatal Outcome , Hydrops Fetalis/pathology , Teratoma/diagnosis , Teratoma/pathology
7.
Rev. chil. obstet. ginecol ; 80(1): 65-71, 2015. ilus
Article in Spanish | LILACS | ID: lil-743837

ABSTRACT

Se reporta un caso excepcional de tumor de Krukenberg ovárico bilateral asociado a teratoma maduro encontrado en una mujer de 54 años. La ecografía mostró al lado derecho tumor ovárico sólido de 55 mm y al lado izquierdo tumor quístico de 125 mm. Se realizó histerectomía total, salpingooforectomía bilateral, resección del epiplón mayor y muestras peritoneales. Al tercer día postcirugía, la paciente presentó signos de tromboembolismo pulmonar masivo y aunque recibió terapia anticoagulante falleció al quinto día postoperatorio. El estudio histológico mostró infiltración masiva de carcinoma de células en anillo positivas para citoqueratina en ambos ovarios. El ovario derecho mostró la forma sólida clásica del tumor de Krukenberg mientras que el ovario izquierdo correspondió a un quiste dermoide con infiltración tumoral de carcinoma de células en anillo en la pared.


An exceptional case of bilateral Krukenberg tumor of the ovary associated with mature teratoma presented in a 54 years old patient is reported. The ultrasound showed a 55 mm solid right ovarian tumor and a 125 mm left cystic ovarian tumor. Hysterectomy and bilateral salpingoophorectomy was performed including omental resection and peritoneal biopsies. Massive pulmonary embolism was detected in the third day after the surgery. Even anticoagulant therapy was established the patient died in the fifth postoperative day. The histological study revealed massive infiltration of signet ring cell carcinoma with positive expression for cytokeratin in both ovaries. The right ovary showed the classical solid form of the tumor. The left ovary was a dermoid cyst with signet ring cell carcinoma infiltrating the cystic wall.


Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/complications , Ovarian Neoplasms/diagnostic imaging , Teratoma/complications , Teratoma/diagnostic imaging , Krukenberg Tumor/complications , Krukenberg Tumor/diagnostic imaging , Ovarian Neoplasms/surgery , Ovarian Neoplasms/pathology , Teratoma/surgery , Teratoma/pathology , Ultrasonography , Fatal Outcome , Carcinoma, Signet Ring Cell , Krukenberg Tumor/surgery , Krukenberg Tumor/pathology , Hysterectomy
8.
Acta pediátr. hondu ; 3(2): 230-235, oct.- 2012. ilus
Article in Spanish | LILACS | ID: biblio-884686

ABSTRACT

Los Teratoma son tumores que contienen más de dos capas germinales del embrión, de localización variable, frecuentes en la infancia, benignos en su mayoría, con una base genética en estudio, cuyo tratamiento y pronostico va a depender de múltiples factores dentro de los que destaca su com - portamiento histológico...(AU)


Subject(s)
Humans , Female , Child, Preschool , Germ Cells , Giant Cell Tumors/congenital , Neoplasms/congenital , Teratoma/complications
10.
Article in English | IMSEAR | ID: sea-138684

ABSTRACT

Intrathoracic teratoma usually occurs in the mediastinum but rarely, these may originate from the lung. We report a case of an intrapulmonary teratoma in a 34-year-old male.


Subject(s)
Adult , Hair , Humans , Lung Neoplasms/complications , Lung Neoplasms/diagnostic imaging , Male , Teratoma/complications , Teratoma/diagnostic imaging , Tomography, X-Ray Computed
13.
Indian J Pediatr ; 2010 Apr; 77(4): 452-453
Article in English | IMSEAR | ID: sea-142559

ABSTRACT

Teratomas form the most common type of congenital brain tumors, frequently presenting as stillbirth. The largest neonatal series of intracranial teratomas reported a 12% survival rate. Although the first teratoma of the lateral ventricle was reported in 1961 by Maier, neonatal intracranial teratoma of the lateral ventricle is an extremely rare entity. We report here a large intracranial poorly differentiated teratoma arising from choroid plexus of lateral ventricle. This typically presented at birth with a large congenital hydrocephalus.


Subject(s)
Choroid Plexus Neoplasms/complications , Choroid Plexus Neoplasms/congenital , Choroid Plexus Neoplasms/pathology , Humans , Hydrocephalus/etiology , Infant, Newborn , Male , Teratoma/complications , Teratoma/congenital , Teratoma/pathology
15.
Cir. & cir ; 77(5): 403-406, sept.-oct. 2009. ilus
Article in English | LILACS | ID: lil-566466

ABSTRACT

Introducción: El teratoma primario de recto es una entidad extremadamente rara; se ha sugerido que deriva de células germinales aberrantes del tracto digestivo embrionario. Una complicación inusitada es que el tumor ovárico erosione la pared rectal y permita la formación de una fístula para así alojarse en el interior del recto. Caso clínico: Mujer de 54 años de edad con sangrado transanal. Por endoscopia se observó tumor cubierto de pelos en su superficie, localizado a 15 cm del margen anal. Una tomografía computarizada identificó la localización exacta y la presencia de tejido óseo en su interior. Mediante laparotomía se apreció el ovario izquierdo fusionado a la cara anterior del recto, de donde se originaba un tumor de 5 × 4 cm que protruía hacia su luz. Se realizó ooforectomía izquierda y mediante sección peritumoral de la pared intestinal se extrajo el tumor del interior del recto y se cerró el defecto con suturas simples. El estudio histológico demostró conglomeración de tejidos correspondiente a los tres estratos germinales. Conclusiones: Aunque es raro, el diagnóstico de teratoma de ovario intrarrectal debe ser considerado en pacientes con tumores del recto. El diagnóstico es relativamente fácil ante la presencia de pelos en la superficie tumoral, que se evalúa mediante endoscopia.


BACKGROUND: Primary rectal teratoma is a very rare entity. It has been suggested that these tumors grow from aberrant germinal cells of the embryonic digestive tract. Ovarian tumor can also erode the rectal wall, allowing the formation of a fistula localized inside the rectum, becoming an extremely rare complication. CLINICAL CASE: We report the first case of a 54-year old woman with transanal bleeding whose endoscopic investigation showed a hairy-covered tumor in its surface localized 15 cm from the anal margin. Scanning detected its exact location and the presence of bony tissue within. By means of a laparotomy, we identified the left ovary fusioned to the anterior face of the rectum where a 5 x 4 cm tumor was originally protruding towards its lumen. Left oophorectomy was performed and through a peri-tumoral section of the intestinal wall we extracted the tumor from the inner rectum and closed the defect with simple sutures. Histological report demonstrated a conglomerate of tissues that corresponded to the three germinal layers. CONCLUSIONS: Although rare, diagnosis of intrarectal ovarian teratoma must be considered as a differential diagnosis in patients with rectal tumors. Diagnosis is relatively easy in the presence of a tumor with a hairy surface that is evaluated endoscopically. For treatment we suggest a simple procedure with adequate results.


Subject(s)
Humans , Female , Middle Aged , Neoplasm Invasiveness , Ovarian Neoplasms/pathology , Rectum/pathology , Teratoma/pathology , Cell Differentiation , Diagnosis, Differential , Gastrointestinal Hemorrhage/etiology , Laparotomy , Ovarian Neoplasms/complications , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/surgery , Rectal Neoplasms/diagnosis , Ovariectomy , Rectum/surgery , Teratoma/complications , Teratoma/diagnosis , Teratoma/surgery
16.
Ann Card Anaesth ; 2009 Jan-Jun; 12(1): 63-6
Article in English | IMSEAR | ID: sea-1662

ABSTRACT

Intrapericardial tumours can cause cardiac compromise either from pericardial effusion producing cardiac tamponade or from the mass obstructing the outflow from the heart or both. Respiratory embarrassment may also be present if the mass compresses the trachea or the main stem bronchus. A 1-month-old child presented in the emergency needing prompt measures to relieve compressive symptoms. Successful anaesthetic and surgical management led to uneventful recovery. Histopathology of the mass revealed a rarely occurring intrapericardial teratoma. After surgical removal, the child had clinical follow-up for more than a year. Intrapericardial teratoma is a rare entity that presents a diagnostic and therapeutic challenge. The authors describe the case of a 1-month-old male child with this condition who was successfully managed by resection of the mass.


Subject(s)
Anesthesia, General/methods , Heart Neoplasms/complications , Humans , Infant, Newborn , Male , Pericardial Effusion/etiology , Pericardium/surgery , Respiratory Distress Syndrome, Newborn/etiology , Teratoma/complications , Treatment Outcome
18.
Indian J Pathol Microbiol ; 2008 Jul-Sep; 51(3): 389-91
Article in English | IMSEAR | ID: sea-74224

ABSTRACT

Atypical teratoid /rhabdoid tumor (AT/RT) of the central nervous system is a rare but highly aggressive neoplasm that usually affects young children and infants and follows a rapidly fatal course. We report a case of AT/RT in a 3-month-old male infant who also had coincidental unilateral congenital cataract even though there was no associated congenital infectious disease.


Subject(s)
Cataract/complications , Central Nervous System/pathology , Central Nervous System Neoplasms/complications , Fatal Outcome , Humans , Infant , Male , Rhabdoid Tumor/complications , Teratoma/complications
19.
Iranian Journal of Radiology. 2008; 5 (4): 195-198
in English | IMEMR | ID: emr-87241

ABSTRACT

Mature teratomas are the most common type of mediastinal germ cell tumors. They typically occur in young adults [15 to 35 years] and 95% of these teratomas occur in the anterior mediastinum. Herein, we report a case of a huge mediastinal teratoma in a 16-year-old boy who presented with a history of chest pain, cough, exertional dyspnea, and fever. Chest X-ray and spiral computed tomography [CT] revealed a bulky mass of 20 cm X 15 cm in the right side of the posterior mediastinum. The operative finding was a large cystic mass in the posterior mediastinum adherent to the neighbor organs. The cyst was filled with sebum, hair and calcified materials. The resected tumor was in the posterior mediastinum, although most of these tumors occur in the anterior mediastinum. To the best of our knowledge, this is the first documented report in Iran


Subject(s)
Humans , Male , Teratoma/complications , Mediastinal Neoplasms/diagnosis , Tomography, X-Ray Computed
20.
PAFMJ-Pakistan Armed Forces Medical Journal. 2008; 58 (3): 357-359
in English | IMEMR | ID: emr-94456
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