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1.
Brasília; s.n; 4 ago. 2020.
Non-conventional in Portuguese | PIE, LILACS, BRISA, PIE | ID: biblio-1117744

ABSTRACT

O Informe Diário de Evidências é uma produção do Ministério da Saúde que tem como objetivo acompanhar diariamente as publicações científicas sobre tratamento farmacológico e vacinas para a COVID-19. Dessa forma, são realizadas buscas estruturadas em bases de dados biomédicas, referentes ao dia anterior desse informe. Não são incluídos estudos pré-clínicos (in vitro, in vivo, in silico). A frequência dos estudos é demonstrada de acordo com a sua classificação metodológica (revisões sistemáticas, ensaios clínicos randomizados, coortes, entre outros). Para cada estudo é apresentado um resumo com avaliação da qualidade metodológica. Essa avaliação tem por finalidade identificar o grau de certeza/confiança ou o risco de viés de cada estudo. Para tal, são utilizadas ferramentas já validadas e consagradas na literatura científica, na área de saúde baseada em evidências. Cabe ressaltar que o documento tem caráter informativo e não representa uma recomendação oficial do Ministério da Saúde sobre a temática. Foram encontrados 16 artigos e 13 protocolos.


Subject(s)
Humans , Coronavirus Infections/drug therapy , Betacoronavirus/drug effects , Pneumonia, Viral/drug therapy , Technology Assessment, Biomedical , Tetracyclines/therapeutic use , Vitamin D/therapeutic use , Chloroquine/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Azithromycin/therapeutic use , Antirheumatic Agents/therapeutic use , Ritonavir/therapeutic use , Etoposide/therapeutic use , Lopinavir/therapeutic use , Hydroxychloroquine/therapeutic use
2.
Rev. Asoc. Odontol. Argent ; 103(1): 35-46, mar.2015. tab
Article in Spanish | LILACS | ID: lil-758496

ABSTRACT

Las enfermedades periodontales son consecuencia de la acumulación de la placa dental. Las bacterias presentes en ella inician un proceso inflamatorio en los tejidos periodontales por medio de la liberación de toxinas bacterianas. El tratamiento indicado implica terapias mecánicas no quirúrgicas y quirúrgicas y, en algunos casos, terapia farmacológica. En pacientes que no responden a la terapia mecánica, los estudios sugieren el uso de terapias complementarias con antibióticos locales o sistémicos. En esos casos, es necesario el desarreglo previo de la placa dental adherida a la superficie radicular. Los antibióticos, junto con el raspado y alisado radicular (RAR) y el colgajo periodontal, son una alternativa de agentes terapéuticos, pues garantizan resultados satisfactorios en el tratamiento periodontal. El objetivo de esta revisión es analizar las propiedades de los antibióticos como agentes coadyuvantes de la terapia periodontal...


Subject(s)
Humans , Anti-Bacterial Agents/therapeutic use , Periodontal Diseases/drug therapy , Administration, Buccal , Amoxicillin/therapeutic use , Drug Combinations , Drug Interactions , Macrolides/therapeutic use , Metronidazole/therapeutic use , Quinolones/therapeutic use , Systemic Management , Tetracyclines/therapeutic use
3.
Acta odontol. venez ; 52(2)2014. ilus
Article in Spanish | LILACS | ID: lil-777789

ABSTRACT

En la presente investigación pretendemos optimizar los resultados, evitando la coloración coronal, en procedimientos odontológicos donde sea imprescindible el uso de tetraciclinas así como evaluar la disminución de las coloraciones coronales, al aplicar un antioxidante (Acido Ascórbico) en dientes tratados con tetraciclinas (Minociclina y Doxiciclina). Estudio experimental de investigación básica, de tipo ensayo clínico. En los dientes tratados con minociclina y doxiciclina observamos cambios en la coloración dentaria apreciables tanto en corona como en la raíz, mientras que en los grupos dentarios donde se añadió el antioxidante (ácido ascórbico) a la tetraciclina no se obtuvo esa tinción. La adición de ácido ascórbico a minociclina y doxiciclina provoca que la tinción dentaria no se produzca o que se vea significativamente reducid a.


In this research we want to optimize the results, avoiding the coronal coloring, in dental procedures in where the use of tetracyclines is essential as well as evaluating the reduction of coronal discoloration, by applying an antioxidant (ascorbic acid) in the teeth treated with tetracyclines (minocycline and doxycycline). Experimental study of basic research, clinical trial type. Results: In the teeth treated with minocycline and doxycycline we observed changes in the coloration of the teeth both in crown and in the root, while in the tooth groups in which the antioxidant was added to tetracycline we observed that no staining was obtained. The addition of Ascorbic acid to minoclynine and doxyclycline causes that dental stain will not occur or be significant reduced.


Subject(s)
Humans , Male , Female , Ascorbic Acid/administration & dosage , Ascorbic Acid/therapeutic use , Dental Pulp Necrosis/diagnosis , Tetracyclines/administration & dosage , Tetracyclines/therapeutic use , Dental Pulp Diseases , Endodontics , Periapical Diseases
4.
Rev. cuba. estomatol ; 47(2): 260-265, abr.-jun. 2010.
Article in Spanish | LILACS, CUMED | ID: lil-584503

ABSTRACT

El nevus blanco esponjoso (NBE) es una rara condición autosómica dominante, caracterizada por placas blancas bilaterales en la mucosa, de aspecto esponjoso, blandas a la palpación y que pueden escamarse. Los tratamientos son paliativos; y el uso de antibióticos, en especial la tetraciclina, ha demostrando buenos resultados en su control. Este trabajo presenta tres casos clínicos de una familia afectada por NBE, donde se discuten los posibles diagnósticos diferenciales y conductas terapéuticas indicadas. Un paciente masculino de 52 años de edad acudió a la clínica aquejado de lesiones blancas bilaterales. El paciente notó las lesiones 30 años antes, sin lograr un diagnóstico final de las mismas. Después de la anamnesis y del examen clínico fue realizada una biopsia incisional. La reunión de los datos clínicos e histopatológicos llevó al diagnóstico de NBE. Se le solicitó al paciente que indagase entre sus familiares con respecto a lesiones semejantes. Se detectó que el hijo de 19 años y la hija de 25 eran portadores de placas blancas en la mucosa yugal. Como no había afectación estética, se optó por no intervenir en las lesiones. El nevus blanco esponjoso es una lesión genética que debe ser diferenciada de otras patologías localizadas y sistémicas importantes, que tienen repercusiones serias para el individuo. Como no hay un tratamiento curativo para el NBE, el papel del cirujano dentista es diagnosticar esta lesión, aclarar al paciente sobre la naturaleza benigna y autolimitante del NBE y si fuera necesario desde el punto de vista estético, aplicar diferentes modalidades terapéuticas(AU)


The aim of present paper is to introduce three clinical cases from a family affected from nevus spongiosus albus (NSA) and also to discuss the possible differential diagnoses as well as the therapeutical behaviors to be adopted. Clinical case: A man aged 52 seen in our clinic due to bilateral white lesions noted 30 years ago without achieve a final diagnosis of lesions. After anamnesis and physical examination an incision biopsy was taken. The clinical and histopathological data collection allows making the NSA diagnosis. Thus, it was necessary to inquire again into the patient's relatives regarding the existence of similar lesions proving the presence of white plaques in oral mucosa in a son aged 19 and a daughter aged 25. The nevus spongiosus albus is an uncommon genetic lesion that must to be differentiated from other significant localized and systemic pathologies with serious repercussions for the subjects. Since there is not a curative treatment for the NSA, the role of the surgeon-dentist is to diagnose that lesion, to explain clearly to patient on the benign and self-limiting origin of this entity and if it is necessary from the aesthetic point of view, to apply the different therapeutical modalities to control the plaques(AU)


Subject(s)
Humans , Male , Middle Aged , Tetracyclines/therapeutic use , Diagnosis, Differential , Leukokeratosis, Hereditary Mucosal/therapy , Mouth Diseases/physiopathology
5.
Article in English | IMSEAR | ID: sea-51607

ABSTRACT

Rheumatoid arthritis and periodontitis are widely prevalent diseases and are characterized by tissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases share many pathological features. This article reviews their clinical and biological links. However, there are only a limited number of studies in this area, which prevent us from offering clear evidence.


Subject(s)
Animals , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antirheumatic Agents/therapeutic use , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/drug therapy , Arthritis, Rheumatoid/physiopathology , Bone Density Conservation Agents/therapeutic use , Diphosphonates/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Inflammation Mediators/therapeutic use , Periodontitis/complications , Periodontitis/drug therapy , Periodontitis/physiopathology , Tetracyclines/therapeutic use
8.
Rev. méd. Chile ; 131(11): 1313-1320, nov. 2003.
Article in Spanish | LILACS | ID: lil-358953

ABSTRACT

Helicobacter pylori is a relevant pathogen for gastroduodenal diseases in human beings. Although its eradication often improves gastroduodenal diseases, H pylori is acquiring an elevated rate of resistance to various antimicrobials, such as metronidazole, clarithromycin, tetracycline and amoxicillin. Multi-drug resistance is a major problem to select the appropriate treatment of infectious diseases. To improve our understanding on the com-plexity of the problem, in this article we review the resistance mechanisms and give an update on H pylori antimicrobial resistance (Rev Méd Chile 2003; 131: 1313-20).


Subject(s)
Humans , Anti-Bacterial Agents/pharmacology , Drug Resistance, Bacterial , Helicobacter Infections/drug therapy , Helicobacter pylori/drug effects , Amoxicillin/pharmacology , Amoxicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Metronidazole/pharmacology , Metronidazole/therapeutic use , Tetracyclines/pharmacology , Tetracyclines/therapeutic use
9.
Article in English | IMSEAR | ID: sea-34367

ABSTRACT

Scrub typhus is a potentially fatal, febrile disease prevalent in rural Asia. The etiological agent, Orientia tsutsugamushi, is transmitted to humans by the bite of a larval trombiculid mite. No current diagnostic test is sufficiently practical for use by physicians working in rural areas. A new dipstick test using a dot blot immunoassay format has been developed for the serodiagnosis of scrub typhus. We evaluated this test on 83 patients presenting with acute fever of unknown origin at Maharaj Hospital, a tertiary care medical center in Nakhon Ratchasima, Northeast Thailand. The diagnosis of scrub typhus was confirmed in 30 of these patients (36%) by the indirect immunoperoxidase test. The sensitivity of the test was 87% and its specificity was 94%. The dot blot immunoassay dipstick is accurate, rapid, easy to use, and relatively inexpensive. It appears to be the best currently available test for diagnosing scrub typhus in rural areas where this disease predominates.


Subject(s)
Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Chloramphenicol/therapeutic use , Doxycycline/therapeutic use , Female , Fever/diagnosis , Humans , Immunoenzyme Techniques , Male , Middle Aged , Prospective Studies , Reagent Kits, Diagnostic/standards , Scrub Typhus/complications , Sensitivity and Specificity , Tetracyclines/therapeutic use , Thailand/epidemiology
10.
Rev. bras. odontol ; 58(1): 60-4, jan.-fev. 2001. tab
Article in Portuguese | LILACS, BBO | ID: lil-298175

ABSTRACT

O tratamento antibiótico na periodontia objetiva erradicar ou controlar patógenos específicos. Os candidatos a esse tipo de terapia säo pacientes com diagnóstico recente de periodontite ativa ou com história de recorrência da doença pós-tratamento mecânico/cirúrgico. O risco de indicaçäo do tratamento quimioterápico, baseado somente em aspecto clínicos, achados radiográficos ou análise microbiológica restrita, é a ocorrência de falhas no controle dos patógenes existentes ou no conhecimento de novos microorganismos. A decisäo de usar a antibioticoterapia, bem como sua indicaçäo, estäo expostas no trabalho que segue


Subject(s)
Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , Clindamycin/adverse effects , Clindamycin/therapeutic use , Periodontal Diseases/therapy , Erythromycin/adverse effects , Erythromycin/therapeutic use , Gingival Hyperplasia/therapy , Gingivitis/therapy , Metronidazole/adverse effects , Metronidazole/therapeutic use , Penicillins/adverse effects , Penicillins/therapeutic use , Periodontitis/therapy , Systemic Management , Tetracyclines/adverse effects , Tetracyclines/therapeutic use
11.
Mem. Inst. Oswaldo Cruz ; 95(6): 853-4, Nov.-Dec. 2000.
Article in English | LILACS | ID: lil-273440

ABSTRACT

The conjunctivitis produced by Neisseria gonorrhoeae is the less frequently reported clinical form of gonococcal infection. We aim to phenotypically characterize N. gonorrhoeae isolated from conjunctivae sites. A total of six cases of this disease were notified in the Camagüey province, Cuba. All the strains isolated were penicillin-producing, showed the serogroup WI and exhibited the same antimicrobial susceptibility pattern and plasmid profile (2.6-3.2-24.5). The results contribute to the characterization of N. gonorrhoeae strains circulating in our environment


Subject(s)
Humans , Child, Preschool , Adult , Conjunctivitis, Bacterial/microbiology , Neisseria gonorrhoeae/isolation & purification , Gonorrhea/drug therapy , Gonorrhea/microbiology , Neisseria gonorrhoeae/drug effects , Penicillin Resistance , Penicillins/biosynthesis , Penicillins/pharmacology , Penicillins/therapeutic use , Tetracyclines/pharmacology , Tetracyclines/therapeutic use , Tetracycline/pharmacology , Tetracycline/therapeutic use
12.
Mem. Inst. Oswaldo Cruz ; 95(1): 121-6, Jan.-Feb. 2000. tab, ilus
Article in English | LILACS | ID: lil-251324

ABSTRACT

In a study of congenital transmission during acute infection of Toxoplasma gondii, 23 pregnant Balb/c mice were inoculated orally with two cysts each of the P strain. Eight mice were inoculated 6-11 days after becoming pregnant (Group 1). Eight mice inoculated on the 10th-15th day of pregnancy (Group 2) were treated with 100 mg/kg/day of minocycline 48 h after inoculation. Seven mice inoculated on the 10th-15th day of pregnancy were not treated and served as a control (Group 3). Congenital transmission was evaluated through direct examination of the brains of the pups or by bioassay and serologic tests. Congenital transmission was observed in 20 (60.6 per cent) of the 33 pups of Group 1, in one (3.6 per cent) of the 28 pups of Group 2, and in 13 (54.2 per cent) of the 24 pups of Group 3. Forty-nine Balb/c mice were examined in the study of congenital transmission of T. gondii during chronic infection. The females showed reproductive problems during this phase of infection. It was observed accentuated hypertrophy of the endometrium and myometrium. Only two of the females gave birth. Our results demonstrate that Balb/c mice with acute toxoplasmosis can be used as a model for studies of congenital T. gondii infection. Our observations indicate the potential of this model for testing new chemotherapeutic agents against congenital toxoplasmosis.


Subject(s)
Animals , Female , Pregnancy , Mice , Minocycline/therapeutic use , Pregnancy Complications , Tetracyclines/therapeutic use , Toxoplasmosis, Congenital/drug therapy , Uterus/pathology , Blotting, Western , Chronic Disease , Endometrium/pathology , Enzyme-Linked Immunosorbent Assay , Fluorescent Antibody Technique, Indirect , Hypertrophy , Mice, Inbred BALB C , Myometrium/pathology , Toxoplasmosis, Congenital/immunology , Toxoplasmosis, Congenital/prevention & control
13.
15.
Rev. bras. colo-proctol ; 19(1): 19-21, jan.-mar. 1999. ilus
Article in Portuguese | LILACS | ID: lil-282467

ABSTRACT

A actinomicose de cólon direito pela sua rara ocorrência mas com quadro clínico definitivo levou os autores a relatarem este caso. Estudaram esta entidade nos seus aspectos de patogenia, manifestaçöes clínicas, diagnóstico e tratamento. Esta infecçäo atinge principalmente a regiäo cérvico-facial, torácica e abdominal (intestino, útero e anexos). Quando ocorre no intestino, o local menos incomum é a regiäo ileoceal. Mas pode ser visto, excepcionalmente, no cólon e na regiäo anorretal. Ressaltam que o comprometimento a nível entérico é ainda mais raro, podendo se manifestar após uma operaçäo por apendicite aguda. O tratamento cirúrgico e medicamentoso adequados levam à cura sem deixar sequelas


Subject(s)
Humans , Male , Middle Aged , Actinomycosis/pathology , Colon/pathology , Actinomycosis/diagnosis , Actinomycosis/therapy , Penicillins/therapeutic use , Tetracyclines/therapeutic use , Tetracycline/therapeutic use
17.
Rev. argent. dermatol ; 79(1): 10-7, ene.-mar. 1998. ilus, tab
Article in Spanish | LILACS | ID: lil-221107

ABSTRACT

Antecedentes: la demodecidosis es unaectoparasitosis causada por un artrópodo el demodex del cual hay 2 xespecies exclusivas en el hombre; el D. folliculorum y el D. brevis. Objetiovs: nuestro propósito fue determinar la población del demodex en diferentes patologías; rosácea en sus diferentes estadios, demodecidosis, piel sana y comparar estas. Métodos: estudiamos un total de 100 pacientes, 65 mujeres y 35 hombres, entre 18 y 89 años de edad obteniendo la capa superficial del estrato córneo y el contenido del folículo piloso de la piel de la cara con cianoacrilato adhesivo. Resultados: de los 100 pacientes estudiados encontramos 25 casos positivos de los cuales 12 eran rosácea estadio II, 5 demodecidosis, 4 piel sana, 2 rosácea estadio III y 1 rosácea estadio I y IV, siendo 16 del sexo femenino y 9 de sexo masculino con predominio en mayores de 30 años. De estos 25 pacientes 4 presentaron prurito, 20 se higienizaban con agua y jabón, 5 con cremas limpiadoras y 11 utilizaban cosméticos. Conclusiones: el diagnóstico clínico de demodecidosis es orientativo, es necesario demostrar la presencia de 5 ó más demodex por campo de 1cm cuadrado x 10X para confirmarlo, la negatividad de un campo no excluye el diagnóstico positivo


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Arboviruses , Arthropods/parasitology , Diagnosis, Differential , Face/parasitology , Rosacea/diagnosis , Skin Manifestations , Metronidazole/therapeutic use , Tetracyclines/therapeutic use
18.
Medicina (B.Aires) ; 58(2): 160-4, 1998. tab
Article in English | LILACS | ID: lil-212788

ABSTRACT

Bacteriological etiology was investigated in 29 infected asymptomatic infertile males. The localization of the infection and the effect of a long term antibiotic therapy on semen parameters were evaluated. The most frequent etiological agent isolated was Enterococcus faecalis. Positive bacteriological culture was obtained in prostatic fluid in 16 patients and in semen in 13. Bacteriological cure was achieved in 24 cases and it was associated with improved seminal parameters: sperm concentration, motility, viability and total motile sperm per ejaculate. In 5 patients without bacteriological cure there was no change in semen analysis after antibiotic therapy. In 45 percent of the infected patients there were less than 0.5 x 10(6)/ml seminal polymorphonuclear leukocytes. In view of these findings granulocyte concentration seems to be a poor marker to predict infection.


Subject(s)
Adult , Humans , Male , Anti-Infective Agents, Urinary/therapeutic use , Bacterial Infections/drug therapy , Ciprofloxacin/therapeutic use , Infertility, Male , Semen/cytology , Semen/microbiology , Sperm Count , Sperm Motility , Spermatozoa/microbiology , Spermatozoa/pathology , Tetracyclines/therapeutic use , Agglutination Tests , Bacterial Infections/diagnosis , Follow-Up Studies , Infertility, Male/microbiology , Infertility, Male/pathology , Leukocyte Count , Prostate/metabolism , Statistics, Nonparametric
19.
Dermatol. argent ; 3(3): 235-9, jul.-sept. 1997. ilus
Article in Spanish | LILACS | ID: lil-215560

ABSTRACT

Se hace una revisión de los recursos terapéuticos no esteroideos, empleados en el tratamiento de las diferentes formas clínicas de pénfigo. Se enumeran los factores que condicionan la elección de dicha terapéutica; forma clínica, edad, embarazo, concomitancia con otras enfermedades, interacción con otros fármacos y efectos adversos. El esteroide continúa siendo la droga de primera elección, debiendo estar asociado con otras medicaciones adyuvantes, habitualmente desde su inicio, a fin de promover un descenso más rápido del mismo, con menor incidencia de complicaciones. En los pénfigos graves se preferirá su asociacián con inmunosupresores, en primer lugar con la azatioprina o bien con ciclofosfamida. La dapsona, como las tetraciclinas, será alternativa para algunas formas más leves de pénfigo, mientras que los pulsos de ciclofosfamida, así como la plasmaféresis, deberán reservarse para aquellos casos graves que no hayan respondido a las terapéuticas convencionales


Subject(s)
Humans , Azathioprine/adverse effects , Cyclophosphamide/adverse effects , Pemphigus/drug therapy , Azathioprine , Azathioprine/therapeutic use , Cyclophosphamide , Cyclophosphamide/therapeutic use , Cyclosporine , Cyclosporine/therapeutic use , Dapsone , Dapsone/therapeutic use , Photopheresis/standards , Gold , Gold/therapeutic use , Leukopenia/chemically induced , Niacinamide , Niacinamide/therapeutic use , Plasmapheresis/standards , Tetracyclines , Tetracyclines/therapeutic use
20.
J. bras. urol ; 23(1): 9-13, jan.-mar. 1997. ilus, tab
Article in Portuguese | LILACS | ID: lil-219890

ABSTRACT

O câncer de pênis é uma patologia muito frequente no Brasil, sobretudo em regiöes de baixo poder sócio-econômico. No Norte e Nordeste pode ser considerado um problema de saúde pública. As linfadenectomias inguinais, apesar de apresentarem vários aspectos controvertidos, säo amplamente utilizadas com finalidades de diagnóstico, estadiamento e terapêutica. A alta incidência de complicaçöes e a morbidade desses procedimentos podem ser minimizadas com a adoçäo de princípios técnicos mais recentes. Foram estudadas prospectivamente as complicaçöes observadas em 50 pacientes submetidos a linfadenectomias inguinais superficiais e profundas. Extravazamentos linfáticos de variada gravidade foram diagnosticados em 22 por cento dos pacientes, edema significativo dos membros inferiores em 18 por cento, infecçäo cirúrgica em 10 por cento e necrose cutânea em 6 por cento. Näo ocorreram óbitos


Subject(s)
Humans , Male , Adult , Middle Aged , Postoperative Complications/etiology , Lymph Node Excision/adverse effects , Penile Neoplasms/surgery , Cephalosporins/therapeutic use , Postoperative Complications/therapy , Lymphatic Diseases/etiology , Lymph Node Excision/methods , Penile Neoplasms , Tetracyclines/therapeutic use , Tetracycline/therapeutic use
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