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1.
Braz. dent. sci ; 25(1): 1-7, 2022. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1354491

ABSTRACT

Objective: Recent investigations have suggested a correlation between thyroid diseases, particularly hypothyroidism (HT), and oral lichen planus (OLP). Objective: This study aimed to assess the frequency of OLP in HT patients. Material and Methods: This analytical descriptive study evaluated 100 HT patients including 94 females and 6 males, who were selected by convenience sampling. The subjects were clinically examined for OLP. The mean age of patients was 42.49±1.29 years. Also, 100 age- and sex-matched healthy controls were examined. The data were analyzed using chi-square test and Fisher's exact test via SPSS. Results: Of all, 14 (14%) HT patients (12 females and 2 males) had OLP while only one case of OLP was found in the control group. The difference between the two groups in the frequency of OLP was significant (P=0.001). The odds ratio (OR) of developing OLP was calculated to be 16.11 in HT patients. Reticular form was the most common type of OLP in patients (50%). The buccal mucosa was the most common site of involvement (92.85%). The mean age of patients with OLP was 42.93±1.29 years with a median of 46±1.29 years in HT group. Conclusion: The frequency of OLP was significantly higher in HT patients such that HT patients had higher odds of developing OLP by 16 folds. (AU)


Objetivo: Investigações recentes sugeriram uma correlação entre doenças da tireoide, particularmente hipotireoidismo (HT), e líquen plano oral (LPO). Objetivo: Este estudo teve como objetivo avaliar a frequência de LPO em pacientes com HT. Material e Métodos: Este estudo descritivo analítico avaliou 100 pacientes com HT, incluindo 94 mulheres e 6 homens, selecionados por amostragem por conveniência. Os indivíduos foram examinados clinicamente para LPO. A média de idade dos pacientes foi de 42,49 ± 1,29 anos. Além disso, foram examinados 100 controles saudáveis pareados por idade e gênero. Os dados foram analisados usando o teste do qui-quadrado e o teste exato de Fisher via SPSS. Resultados: De todos, 14 (14%) pacientes com HT (12 mulheres e 2 homens) tiveram LPO, enquanto apenas um caso de LPO foi encontrado no grupo controle. A diferença entre os dois grupos na frequência de LPO foi significativa (P = 0,001). A razão de probabilidade de desenvolvimento de LPO foi calculado em 16,11 em pacientes com HT. A forma reticular foi o tipo mais comum de LPO nos pacientes (50%). A mucosa bucal foi o local de acometimento mais comum (92,85%). A média de idade dos pacientes com LPO foi de 42,93 ± 1,29 anos, com mediana de 46 ± 1,29 anos no grupo HT. Conclusão: A frequência de LPO foi significativamente maior em pacientes com HT, de modo que os pacientes com HT tinham maior chance de desenvolver LPO em 16 vezes. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Thyroid Diseases , Lichen Planus, Oral , Hypothyroidism
2.
Article in English | LILACS | ID: biblio-1353156

ABSTRACT

2021.174934ABSTRACTIntroduction: The mechanisms by which hepatitis C virus (HCV) infection induces autoimmune thyroiditis (AIT) have been studied, and it was suggested that inflammatory cytokines during HCV infection would change the thy-roperoxidase (TPO) signaling cascade and thyroglobulin (Tg) determining autoimmune thyroid disease.Objective: To show the signaling pathway, of TPO and Tg, and their potential targets mediated HCV in individuals with hepatitis C.Methods: The mapping of the signaling pathway was based on a review study approach and performed using the automatic annotation server of the Kyoto and Genome Encyclopedia (KEGG). PathVisio is free software for analysis and design of open source routes, and was used for the graphic representation of the signaling pathway.Results: The contigs were extracted from the KEGG database and their mapped transcription represents the signa-ling pathway of the main biomolecules that triggers the AIT. The action of HCV, or its treatment can trigger AIT that is characterized by the presence of autoantibodies against TPO and Tg. In AIT, autoreactive CD4 + T lymphocytes recruit B cells and CD8 + T cells in the thyroid. The progression of the disease leads to the death of thyroid cells and hypothyroidism. Conclusion: HCV or its treatment activates several signaling pathways with thyroid cells damage resulting in AIT and secondary hypothyroidism to cellular apoptosis. (AU)


RESUMOIntrodução: Os mecanismos pelos quais a infecção com o vírus da hepatite C (HCV) induz à tireoidite autoimune (TAI) têm sido alvo de estudos. Tem sido sugerido que citocinas inflamatórias, como a elevação das interleucinas na inflamação causadas pelo HCV, alterariam a cascata de sinalização da tireoperoxidase (TPO) e tireoglobulina (Tg) determinando um quadro de doença autoimune da tireóide.Objetivo: Demonstrar a via de sinalização da TPO e da Tg e seus potenciais alvos para a TAI mediados pelo HCV em indivíduos com hepatite C.Método: O mapeamento da via de sinalização foi realizado usando o servidor de anotação automática da Enciclopé-dia Quioto de Genes e Genomas (KEGG). O PathVisio, um software gratuito de análise e desenho de vias de código aberto, foi utilizado para a representação gráfica da via de sinalização.Resultado: As sequências foram retiradas do banco de dados KEGG e sua transcrição mapeada representa a via de . sinalização das principais biomoléculas que desencadeia a TAI. A ação do HCV, ou seu tratamento pode desen-cadear a TAI que é caracterizada pela presença de autoanticorpos contra a TPO e Tg. Na TAI os linfócitos T CD4+ auto-reativos recrutam células B e células T CD8+ na tireóide. A progressão da doença leva à morte de células da tireóide e hipotireoidismo.Conclusão: O HCV ou o seu tratamento ativa várias vias de sinalização com dano na célula tireoidiana, tendo como resultado TAI e hipotireoidismo secundário a apoptose celular. (AU)


Subject(s)
Humans , Autoimmune Diseases , Thyroid Diseases , Thyroiditis, Autoimmune , CD4 Antigens , CD8 Antigens , Hepacivirus , Disease Progression , Hypothyroidism
3.
An. bras. dermatol ; 96(5): 539-543, Sept.-Oct. 2021. tab
Article in English | LILACS | ID: biblio-1345134

ABSTRACT

Abstract Background: The frequency of autoimmune diseases and thyroid cancer has been increasingly reported in association with rosacea. However, studies investigating thyroid diseases in rosacea are scarce with conflicting results. Objective: To investigate the relationship between thyroid disorders and rosacea. Methods: A large case-control study on ageand gender-matched 2091 rosacea patients and 9572 controls was conducted. Rosacea patients using the rosacea-specific ICD codes were compiled from the hospital records. Additionally, all participants were evaluated in terms of the presence of hypothyroidism and hyperthyroidism. Conditional logistic regression analysis was used to compute case-control odds ratios (OR) with 95% confidence intervals. Results: The analysis comprehended 2091 rosacea patients (1546 female, 545 male; mean 48.73 ± 14.53 years) and 9572 controls (7009 female, 2563 male; mean 48.73 ± 15.1 years). Whereas the rate of hypothyroidism was significantly higher in rosacea patients (OR = 1.3, 95% CI 1.13-1.49, p < 0.001), there was no significant difference in the rate of hyperthyroidism between the groups (OR = 1.12, 95% CI 0.81-1.53, p = 0.497). Stratification for gender revealed a significant association between hypothyroidism and rosacea in females (OR = 1.27, 95% CI 1.1-1.47, p = 0.002) and males (OR = 1.58, 95% CI 1.04-2.4, p = 0.032). The frequency of hypothyroidism in rosacea patients increased towards the age range of 40-49 and then decreased, parallel with the hypothyroidism frequency of the study population. Study limitations: Different subtypes and severities of rosacea were not distinguished. Conclusions: Hypothyroidism may be a comorbidity of rosacea and investigation for hypothyroidism may be appropriate when evaluating rosacea patients.


Subject(s)
Humans , Male , Female , Thyroid Diseases , Rosacea/complications , Rosacea/epidemiology , Hyperthyroidism/complications , Hyperthyroidism/epidemiology , Case-Control Studies
4.
Rev. cuba. pediatr ; 93(3): e1505, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347539

ABSTRACT

Introducción: La diabetes mellitus tipo 1 es una enfermedad autoinmunitaria que se relaciona con alteraciones tiroideas. Objetivo: Describir la relación que existe entre diabetes mellitus tipo 1 y enfermedad tiroidea autoinmune. Métodos: Se realizó una revisión de la literatura nacional e internacional de los últimos 15 años en bases de datos, en español y en inglés. Se utilizaron las siguientes palabras clave: "diabetes mellitus tipo 1", "autoinmunidad", enfermad tiroidea autoinmune", "disfunción tiroidea" y "anticuerpos antitiroideos. Análisis e integración de la información: La alteración más frecuente es el hipotiroidismo subclínico y se presenta con mayor frecuencia en el sexo femenino, por lo que se sugiere realizar periódicamente el perfil tiroideo a estos pacientes. Conclusiones: Se debe tener en cuenta en la práctica clínica estas implicaciones para brindar un tratamiento oportuno, mejorar complicaciones derivadas como las enfermedades cardiovasculares y disminuir las cifras de morbilidad y mortalidad(AU)


Introduction: Type 1 diabetes mellitus is an autoimmune disease that is related to thyroid abnormalities. Objective: Describe the relationship between type 1 diabetes mellitus and autoimmune thyroid disease. Methods: A review of the national and international literature of the last 15 years was carried out in databases, in Spanish and in English. The following keywords were used: "type 1 diabetes mellitus", "autoimmune", "autoimmune thyroid disease", "thyroid dysfunction" and "antithyroid antibodies. Analysis and integration of information: The most common alteration is subclinical hypothyroidism and it occurs most often in the female sex, so it is suggested to periodically perform the thyroid profile to these patients. Conclusions: These implications should be taken into account in clinical practice to provide timely treatment, improve complications such as cardiovascular disease and reduce morbidity and mortality figures(AU)


Subject(s)
Humans , Thyroid Diseases/therapy , Thyroiditis, Autoimmune , Diabetes Mellitus, Type 1/etiology , Review Literature as Topic
5.
Braz. j. biol ; 81(3): 592-600, July-Sept. 2021. tab, graf
Article in English | LILACS | ID: biblio-1153379

ABSTRACT

Abstract Understanding the relation between the environmental stress factors and the hypothalamus-pituitary-thyroid (HPT) axis efficiency can reduce the susceptibility to thyroid diseases. In our study, thyroid dysfunction was induced in female rats by administration of 40 mg Na F/kg.bd.wt/day for a month. Co-administration of the water extract of Arca noae (300 mg/kg. bw) was tested as a treatment for Na F induced thyroid dysfunction. A group of rats injected Arca noae extract only (300 mg/kg.bd.wt) was performed to observe the impact of the extract on the (HPT) axis in addition to the normal control group. Results showed that there was a significant decrease in serum triglycerides, total protein and albumin levels in the fluoride supplemented group in addition to abnormal levels of TSH, (T4) and (T3) compared to the control group. In the treated group there was an improvement in the proteins level and lipid profile but pseudo-corrected serum (T4) and (T3) levels were observed in addition to a continuous increase in TSH level. Histological findings confirmed the harmful effect of fluoride on both the non treated and the treated groups. Consequently, fluoride supplementation must be considered as a harmful stress that may affect permanently the HPT axis.


Resumo Compreender a relação entre os fatores de estresse ambiental e o eixo hipotálamo-hipófise-tireoide (HPT) pode reduzir a suscetibilidade a doenças da tireoide. Em nosso estudo, a disfunção tireoidiana foi induzida em ratos fêmeas pela administração de 40 mg Na F/kg.bw/dia durante um mês. A administração concomitante do extrato aquoso de Arca noae (300 mg/kg.Pc) foi testada como tratamento para a disfunção tireoidiana induzida por Na F. Um grupo de ratos injetados apenas com extrato de Arca noae (300 mg/kg. Pc) foi pré-formado com o intuito de observar o impacto do extrato no eixo (HPT), além do grupo controle normal. Os resultados mostraram que houve uma diminuição significativa nos níveis séricos de triglicerídeos, proteína total e albumina no grupo suplementado com fluoreto, além de níveis anormais de TSH, (T4) e (T3) em comparação ao grupo controle. No grupo tratado, houve uma melhora no nível de proteínas e perfil lipídico. Os níveis séricos pseudocorrigidos (T4) e (T3) foram observados, além de um aumento contínuo no nível de TSH. Os achados histológicos confirmaram o efeito prejudicial do flúor nos grupos não tratado e tratado. Consequentemente, a suplementação de flúor é considerada um estresse prejudicial que pode afetar permanentemente o eixo HPT.


Subject(s)
Animals , Female , Rats , Thyroid Diseases , Thyrotropin , Thyroxine , Aquatic Organisms
6.
Rev. bras. oftalmol ; 80(2): 127-132, Mar.-Apr. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1280102

ABSTRACT

RESUMO Objetivo: Conheça as características demográficas e clínicas da Órbita Associada da Tiroide (OAT), bem como a taxa de exigência da cirurgia orbital em pacientes do Centro Médico Nacional do Oeste. Métodos. Estudo observacional, transversal, descritivo e retrospetivo realizado analisando os registos de pacientes diagnosticados com OAT tratados num centro de cuidados de terceiro nível de janeiro de 2005 a julho de 2016. Os resultados. Um total de 236 órbitas de 118 pacientes foram avaliados, com uma idade média de 47,3 (13,2 anos, 74,6% eram do sexo feminino e 25,4% masculinos. 4,2% dos doentes foram tratados com hipotiroidismo, 94,1% com hipertireoidismo e 1,7% com goiter tóxico difuso. 44,9% dos doentes estudados com restrição de movimento ocular,10,2% com queratopatia de exposição e 51,7% com hipertensão intraocular. 34,7% dos doentes avaliados no serviço necessitaram de descompressão orbital, 16,1% de cirurgia palpebral e 8,5% de correção do hatrabisma. Na gestão conservadora destes doentes, 48,3% exigiam o uso de lubrificantes tópicos dos olhos, enquanto 52,5% dos pacientes necessitavam do uso de hipotensivos oculares em número variável. As conclusões. A OAT foi associada principalmente ao hipertiroidismo, sendo mais comum em pacientes do sexo feminino entre os 40 e os 59 anos; mais de 50% dos pacientes necessitaram do uso de hipotensivos oculares. Da mesma forma, a gestão cirúrgica foi realizada em mais de 50% dos pacientes, sendo a descompressão orbital a intervenção mais frequente.


ABSTRACT Objective. To know the demographic and clinical characteristics of Thyroid Associated Orbitopathy (TAO), as well as the requirement rate of orbital surgery in patients of the Orbit Service in the National Medical Center of the West, IMSS. Methods. Observational, cross-cutting, descriptive and retrospective study carried out analyzing the records of patients diagnosed with TAO and treated at a third-level care center from January 2005 to July 2016. Results. A total of 236 orbits of 118 patients were valued, with an average age of 47.3 ± 13.2 years, 74.6% were female and 25.4% male. 4.2% of patients were treated with hypothyroidism, 94.1% with hyperthyroidism and 1.7% with diffuse toxic goiter. 44.9% of patients studied had eye movement restriction,10.2% exposure keratopathy and 51.7% intraocular hypertension. 34.7% of patients valued in the service required orbital decompression, 16.1% palpebral surgery and 8.5% strabism correction. In the conservative management of these patients 48.3% required the use of topical eye lubricants, while 52.5% required the use of eye hypotensives in variable numbers. Conclusions. TAO was mainly associated with hyperthyroidism, being more common in female patients between the age of 40 and 59; more than 50% of patients required the use of eye hypotensives. Likewise, surgical management was performed in more than 50% of patients, with orbital decompression being the most frequent intervention.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Orbital Diseases/surgery , Orbital Diseases/etiology , Ophthalmologic Surgical Procedures/statistics & numerical data , Thyroid Diseases/complications , Exophthalmos/surgery , Exophthalmos/etiology , Orbit/surgery , Exophthalmos/diagnosis , Graves Disease/complications , Cross-Sectional Studies , Retrospective Studies , Decompression, Surgical/methods , Intraocular Pressure
8.
Gac. méd. Méx ; 157(2): 140-146, mar.-abr. 2021. tab
Article in Spanish | LILACS | ID: biblio-1279093

ABSTRACT

Resumen Introducción: La historia familiar de enfermedad tiroidea (HFET) como factor de riesgo para hipotiroidismo congénito (HC), en síndrome de Down (SD) aún no ha sido explorada. Objetivo: Determinar si la HFET está asociada a mayor riesgo de HC en neonatos con SD. Método: Estudio de casos y controles en 220 neonatos con SD. Se compararon las pruebas de función tiroidea (PFT) de 37 con SD e HFET (casos), frente a las PFT de 183 recién nacidos con SD sin HFET (grupo de referencia). Se realizó análisis de regresión logística multivariante y se calculó la razón de momios (RM) y sus respectivos intervalos de confianza del 95 % (IC 95 %). Resultados: Nueve casos HC (4.1 %). El HC mostró asociación con la HFET (RMa = 8.3, IC 95 %: 2.0-34.3), particularmente en los varones (RMa = 9.0, IC 95 %: 1.6-49.6). La ausencia de HFET tuvo una RM de protección para HC (RMa = 0.4, IC 95 %: 0.1-0.8). Conclusiones: La HFET puede es una estrategia fácil y accesible para identificar pacientes con SD con mayor riesgo de HC.


Abstract Introduction: Family history of thyroid disease (FHTD) as risk factor for congenital hypothyroidism (CH) in patients with Down syndrome (DS) has not yet been explored. Objective: To determine whether FHTD is associated with an increased risk for CH in DS. Method: Case-control study in 220 neonates with DS. Thyroid function tests of 37 infants with DS and FHTD (cases) were compared with those of 183 DS newborns without FHTD (reference group). Data were analyzed using multivariate logistic regression analysis and adjusted odds ratios (aORs) with their respective 95 % confidence intervals (CI) were calculated. Results: Nine newborns with DS in our sample had CH (4.1 %). FHTD showed an association with CH in neonates with DS (aOR = 8.3, 95 % CI: 2.0-34.3), particularly in males (aOR = 9.0, 95 % CI: 1.6-49.6). In contrast, newborns with DS without FHTD were less likely to suffer from CH (aOR = 0.4, 95 % CI: 0.1-0.8). Conclusions: FHTD detailed evaluation can be an easy and accessible strategy to identify those newborns with DS at higher risk for CH.


Subject(s)
Humans , Male , Female , Infant, Newborn , Thyroid Diseases/genetics , Family Health , Down Syndrome/complications , Congenital Hypothyroidism/etiology , Thyroid Function Tests/statistics & numerical data , Sex Factors , Epidemiologic Methods , Congenital Hypothyroidism/epidemiology
9.
Rev. venez. oncol ; 33(1): 33-39, mar. 2021. ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1147475

ABSTRACT

La hemiagenesia tiroidea representa un trastorno congénito caracterizado por la ausencia de desarrollo de uno de los lóbulos tiroideos, asociado o no a ausencia del istmo. Es más frecuente en las mujeres y por lo general se presenta como falta del lóbulo izquierdo, con hipertrofia compensatoria del lóbulo contralateral. Su diagnóstico es generalmente incidental o por manifestaciones del lóbulo tiroideo presente. Se hizo una revisión bibliografía, en donde no se encontraron casos reportados en Venezuela de hemiagenesia o agenesia tiroidea, describiéndose el siguiente. Presentamos a una paciente de 50 años de edad, conocida con hipotiroidismo desde los 31 años, negando cualquier cirugía en el área de cabeza y cuello. Desde febrero 2019 presentó aumento progresivo de volumen en región anterior de cuello. Al examen físico se observó aumento de volumen en región anterior derecha del cuello, palpándose lóbulo tiroideo derecho aumentado de tamaño, de aspecto nodular, no doloroso. En ecosonograma tiroideo se concluyó como bocio tiroideo derecho de aspecto multinodular, con ausencia del lóbulo izquierdo. Perfil tiroideo dentro de límites normales. Se lleva a mesa operatoria corroborándose ausencia del lóbulo izquierdo y presentado en la biopsia definitiva hiperplasia nodular en el lóbulo derecho. Se discute su frecuencia, la forma de presentación y se hace revisión de la literatura(AU)


Thyroid hemiagenesis represents a congenital disorder characterized by the absence of development of one of thyroid lobes, associated or not with absence of isthmus. It is more frequent in women and generally presents as absence of the left lobe, with compensatory hypertrophy of the contralateral lobe. Its diagnosis is generally incidental or by manifestations of the present thyroid lobe. A bibliography review was made, where no cases reported in Venezuela of hemiagenesis or thyroid agenesis were found, describing the following. We present a 50-year-old patient, known with hypothyroidism since she was 31, denying any surgery in the head and neck area. Since February 2019, presented a progressive increase in volume in the anterior neck region. On physical examination, an increase in volume was observed in right anterior region of the neck, palpating an enlarged right thyroid lobe, with a nodular appearance and not painful. In a thyroid echo-sonogram, it was concluded as a right thyroid goiter with a multinodular appearance, with the absence of the left lobe. Thyroid profile within normal limits. It is taken to the operating table, confirming the absence of the left lobe and presented in the definitive biopsy nodular hyperplasia in the right lobe. Its frequency, form of presentation, and literature review are discussed(AU)


Subject(s)
Humans , Female , Middle Aged , Thyroid Gland/physiopathology , Goiter , Hypothyroidism/surgery , Thyroid Diseases , Triiodothyronine , Ultrasonography
10.
Acta sci. vet. (Impr.) ; 492021. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1363750

ABSTRACT

Thyroid gland diseases are the most common endocrinopathies in feline practice. Diagnosis and surgical treatment must base on solid anatomical knowledge about the gland size, localization, and blood supply. However, some textbooks provide a general anatomical description of the thyroid gland of domestic carnivores. Thus, specific details of the feline gland are missing. The present study aimed to investigate the dimensions, topography, and arterial supply of the thyroid gland in Brazilian shorthair cats and, therefore, provide additional data to diagnose and treat feline thyroid diseases. Thirty Brazilian shorthair cats formalin-fixed cadavers (15 male and 15 female) were injected with red-stained latex solution by a canula in the thoracic aorta. The necropsy unit of the Rural Federal University of Rio de Janeiro donated the specimens. The study included only adult animals with no history of thyroid disease. After the fixation period, the cadavers were dissected to investigate the measurements (length, width at cranial and caudal poles, and thickness), topography, and in situ arterial supply of the thyroid lobes. The mean measurements of the length, cranial pole width, caudal pole width, and thickness in the right lobe were 19.39 ± 3.10 mm, 5.36 ± 1.40 mm, 3.67 ± 0.93 mm, and 1.30 ± 0.29 mm, respectively; and 20.29 ± 3.35 mm, 4.85 ± 1.58 mm, 3.88 ± 0.91 mm, 1.64 ± 0.65 mm in the left lobe, respectively. There were no statistical differences (P > 0.05) in the comparison of the measures between sexes or antimers (sides). Pearson's linear correlation detected a positive, moderate (r = 0.55), and significant (P < 0.05) correlation between the right and left lobe lengths. In 70% of the cats, both left and right lobes had the cranial poles located at the same level. Typically, the lobes extended between the first to the eighth tracheal ring. However, the cranial pole of some lobes located as cranially as the cricoid cartilage level, and the caudal pole as caudally as the 12th tracheal ring. Fifty-six percent of the cats had a ventrally located isthmus. In all the sampling, one single thyroid artery emerged as a branch of the common carotid artery and provided branches directly to the thyroid lobe, isthmus and the adjacent muscles and esophagus. Besides establishing average dimensions of normal thyroid lobes in Brazilian shorthair cats, this study detected no significant difference between the average measurements of right and left lobes. Also, a positive linear correlation between the length and width of the right and left lobes became evident. Therefore, the practitioner must consider suspicious any length asymmetry between right and left thyroid lobes until further endocrine test proves otherwise. Most of the cats had the right and left thyroid lobe positioned at the same transversal level; however, positional asymmetries are not uncommon. Unlike dogs, Brazilian shorthair cats have only a single artery to supply each lobe: the thyroid artery. In a feline thyroidectomy, the surgeon must avoid blindly ligating the thyroid artery since this vessel also provided numerous branches to adjacent muscles and esophagus. In a bilateral thyroidectomy, the ventral region between lobes should be thoroughly inspected for the common presence of an isthmus. Sometimes, the surgeon may need to extend the incision caudally beyond the 12th tracheal ring level to visualize the gland tissue entirely.(AU)


Subject(s)
Animals , Cats , Arteries , Thyroid Diseases/veterinary , Thyroid Gland/anatomy & histology , Thyroid Gland/blood supply , Cat Diseases/diagnosis , Cats
11.
Rev. méd. hondur ; 89(1, supl): 39-45, 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1281200

ABSTRACT

Las enfermedades tiroideas han presentado un auge en los últimos tiempos, aumentando consigo mismo el reporte de las intervenciones quirúrgicas. La tiroidectomía es una de las cirugías más practicadas en endocrinología y tras su realización se han descrito complicaciones, siendo éstas vinculadas a ciertos factores de riesgos que potencian su aparición. Se realizó búsqueda bibliográfica en el período comprendido entre febrero de 2018 a diciembre de 2019, en bases de datos internacionales (PubMed, Cochrane, SCIELO, LILACS y Redalyc) y búsqueda manual en Google Scholar, utilizando los términos complicaciones de tiroidectomías, complicaciones post-quirúrgicas, cirugía de tiroides y tiroidectomías. Se identificaron tres agrupaciones generales de factores de riesgo postquirúrgico: Factores intrínsecos de la enfermedad, comorbilidades del paciente y asociados al procedimiento quirúrgico. Es indispensable identificar y corregir comorbilidades para la prevención de complicaciones postquirúrgicas, puesto que las complicaciones continúan siendo una causa de considerable preocupación.


Subject(s)
Humans , Thyroid Diseases/prevention & control , Thyroidectomy/methods , Endocrine Surgical Procedures/methods , Databases, Bibliographic
12.
J. Health Biol. Sci. (Online) ; 9(1): 1-5, 2021. tab
Article in English | LILACS | ID: biblio-1362911

ABSTRACT

Objetivo: avaliar a prevalência de glaucoma entre os portadores de patologias tireoidianas, acompanhados na Clínica Escola de Saúde (CES) do núcleo de Medicina do Centro Universitário Christus (UNICHRISTUS), Fortaleza ­ Ceará ­ Brazil. Métodos: estudo transversal e descritivo de prontuários de pacientes diagnosticados com hipotireoidismo ou hipertiroidismo pelo Código Internacional de Doenças (CID-10) no sistema eletrônico da CES, entre 2013 e 2018. Pacientes triados foram convidados a realizar um exame oftalmológico na Fundação Leiria de Andrade (FLA). Resultados: dos 499 prontuários triados, 22,8% (114) possuíam diagnóstico confirmado para tireoidopatias, sendo 85,9% (98) com hipotireoidismo, e 14,0% (16) com hipertireoidismo. Desses, 72,0% (101) eram mulheres e 28,0% (13) homens. A faixa etária mais prevalente foi entre 41 a 60 anos de idade, correspondendo a 46,4% (53), sendo 65,7% (75) de Fortaleza ­ Ceará ­ Brasil. As principais comorbidades associadas às tireoidopatias foram hipertensão arterial sistêmica, representando 43,8% (50), seguida de dislipidemia, 26,3% (30) e diabetes mellitus tipo 2 em 13,1% dos pacientes (15). Do total, 25 pacientes foram encaminhados à FLA, 84,0% (21) relataram doenças oculares prévias, 4,0% (1) diagnosticado com escavação aumentada constitucional e 12,0% (3) com diagnóstico de glaucoma primário de ângulo aberto. Conclusão: apesar da hipótese de associação entre o glaucoma e as tireoidopatias, o tamanho amostral não possibilitou inferências sobre o risco aumentado de sua correlação, assim como em outros estudos preexistentes na literatura, sendo necessários mais estudos para elucidar com maior precisão essa associação relevante. Palavras-chave: Glaucoma; Tireoide; Hipotireoidismo; Hipertireoidismo; Pressão Intraocular. Resumo Objective: To evaluate the prevalence of ophthalmological pathologies, between thyroidopathies, for early diagnosis of glaucoma in patients seen at the Clínica Escola de Saúde (CES) of the Medicine Center of the Centro Universitário Christus (UNICHRISTUS), Fortaleza ­ Ceará ­ Brazil. Methods: A cross-sectional study and descriptive analysis of medical records of patients diagnosed with hypothyroidism or hyperthyroidism by the International Classification of Diseases (ICD-10) on the CES electronic system, between 2013 and 2018. Screened patients were invited to perform an eye examination at Fundação Leiria de Andrade (FLA). Results: Of the 499 medical records screened, 22.8% (114) had a confirmed diagnosis for thyroid disorders, 85.9% (98) with hypothyroidism, and 14.0% (16) with hyperthyroidism. Of these, 72.0% (101) were women and 28.0% (13) men. The most prevalent age group was between 41 and 60 years old, corresponding to 46.4% (53), being 65.7% (75) from Fortaleza - Ceará. The main comorbidities associated with thyroid diseases were systemic arterial hypertension, 43.8% (50), followed by dyslipidemia, 26.3% (30), and type 2 diabetes mellitus in 13.1% of patients (15). Of the total, 25 patients were referred to the FLA, 84.0% (21) reported previous eye diseases, 4.0% (1) diagnosticated with increased constitutional excavation, and 12.0% (3) with a diagnosis of primary open-angle glaucoma. Conclusion: Despite the hypothesis of an association between glaucoma and thyroidopathy, the sample size didn't allow inferences about the increased risk of its correlation, as well as in other pre-existing studies in the literature, requiring further studies to elucidate this relevant association.


Objetivo: avaliar a prevalência de glaucoma entre os portadores de patologias tireoidianas, acompanhados na Clínica Escola de Saúde (CES) do núcleo de Medicina do Centro Universitário Christus (UNICHRISTUS), Fortaleza ­ Ceará ­ Brazil. Métodos: estudo transversal e descritivo de prontuários de pacientes diagnosticados com hipotireoidismo ou hipertiroidismo pelo Código Internacional de Doenças (CID-10) no sistema eletrônico da CES, entre 2013 e 2018. Pacientes triados foram convidados a realizar um exame oftalmológico na Fundação Leiria de Andrade (FLA). Resultados: dos 499 prontuários triados, 22,8% (114) possuíam diagnóstico confirmado para tireoidopatias, sendo 85,9% (98) com hipotireoidismo, e 14,0% (16) com hipertireoidismo. Desses, 72,0% (101) eram mulheres e 28,0% (13) homens. A faixa etária mais prevalente foi entre 41 a 60 anos de idade, correspondendo a 46,4% (53), sendo 65,7% (75) de Fortaleza ­ Ceará ­ Brasil. As principais comorbidades associadas às tireoidopatias foram hipertensão arterial sistêmica, representando 43,8% (50), seguida de dislipidemia, 26,3% (30) e diabetes mellitus tipo 2 em 13,1% dos pacientes (15). Do total, 25 pacientes foram encaminhados à FLA, 84,0% (21) relataram doenças oculares prévias, 4,0% (1) diagnosticado com escavação aumentada constitucional e 12,0% (3) com diagnóstico de glaucoma primário de ângulo aberto. Conclusão: apesar da hipótese de associação entre o glaucoma e as tireoidopatias, o tamanho amostral não possibilitou inferências sobre o risco aumentado de sua correlação, assim como em outros estudos preexistentes na literatura, sendo necessários mais estudos para elucidar com maior precisão essa associação relevante


Subject(s)
Glaucoma , Patients , Thyroid Diseases , Thyroid Gland , Women , Comorbidity , Glaucoma, Open-Angle , Early Diagnosis , Diabetes Mellitus, Type 2 , Eye Diseases , Hypothyroidism , Intraocular Pressure , Men
13.
Rev. CEFAC ; 23(2): e2319, 2021. tab, graf
Article in English | LILACS | ID: biblio-1155334

ABSTRACT

ABSTRACT Objective: to verify a possible association between hearing loss and dysphonia, arterial hypertension, diabetes mellitus, thyroid diseases, and noise complaints. Methods: a cross-sectional study involving 60 teachers, mean age 47.05 years. Pure-tone threshold audiometry was used to assess hearing, the voice questionnaire and voice acoustic evaluation were used for voice perception and quality, and the standardized questionnaire verified noise complaint and comorbidities. The statistical analysis was conducted with Mann-Whitney and Fisher's exact tests and multivariate linear regression. Results: there was a significant association between hearing loss and diabetes mellitus, hypertension, and thyroid disease (both p <0.0001), but there was no association between noise complaints and hearing loss in this population. The regression showed that dysphonia (p = 0.0311) and diabetes mellitus (p = 0.0302) are independent risk factors for hearing loss. A correlation was found between hearing loss and voice characteristics: roughness, breathiness, tension, and resonance. Conclusion: this study showed that hypertension and thyroid diseases are factors associated with hearing loss. In addition, dysphonia and diabetes mellitus are independent factors associated with hearing loss in teachers. These results show the need for policies aimed at promoting teachers' health.


RESUMO Objetivo: verificar possível associação da perda auditiva com disfonia, hipertensão arterial (HA), diabetes mellitus (DM), doenças da tireoide e queixas de ruído. Métodos: estudo transversal envolvendo 60 professores, média de idade de 47,05 anos. Foi avaliada a audição por meio da Audiometria tonal limiar, a percepção e qualidade vocal com o questionário vocal e a avaliação vocal acústica, enquanto a queixa de ruído e as comorbidades envolvidas foram investigadas com o questionário padronizado. A análise estatística utilizou os testes Ex-act de Mann Whitney, Fisher e regressão linear multivariada. Resultados: houve associação significante entre perda auditiva e DM, HA e doenças da tireoide (ambas p <0,0001), mas não foi encontrada associação entre queixa de ruído e perda auditiva nesta população. A regressão mostrou que as variáveis disfonia (p = 0,0311) e DM (p = 0,0302) são fatores de risco independentes para perda auditiva. Houve correlação entre perda auditiva e as características vocais rugosidade, soprosidade, tensão e ressonância. Conclusão: este estudo demostrou que HA e doenças da tireoide são fatores associados a perda auditiva, além disso a disfonia e DM se constituem em fatores associados independentes para a perda auditiva em professores. Estes resultados mostram a necessidade de políticas direcionadas a promoção da saúde do professor.


Subject(s)
Humans , Male , Female , Middle Aged , Hearing Loss/etiology , Audiometry, Pure-Tone , Thyroid Diseases/complications , Cross-Sectional Studies , Risk Factors , Diabetes Mellitus , Dysphonia/complications , Hearing Loss/diagnosis , Hypertension/complications , Noise, Occupational/adverse effects
14.
Rev. colomb. reumatol ; 27(supl.2): 58-66, oct.-dic. 2020. graf
Article in Spanish | LILACS | ID: biblio-1341340

ABSTRACT

RESUMEN La poliautoinmunidad se define como la presencia de más de una enfermedad autoinmune (EA) bien caracterizada en un mismo paciente. Es una condición frecuente en pacientes con síndrome de Sjögren (SS) y sigue un patrón de agrupamiento. Las EA más frecuentes observadas en el SS son la enfermedad tiroidea autoinmune, la artritis reumatoide y el lupus eritematoso sistémico. El estudio de este fenómeno aporta claves importantes para entender los mecanismos comunes de las EA.


ABSTRACT Multiple autoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Multiple autoimmunity is a frequent condition in Sjögren's syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. The study of multiple autoimmunity provides important clues for elucidating the common mechanisms of ADs.


Subject(s)
Humans , Sjogren's Syndrome , Autoimmunity , Autoimmune Diseases , Thyroid Diseases , Lupus Erythematosus, Systemic
15.
Rev. cuba. endocrinol ; 31(3): e254, sept.-dic. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1156400

ABSTRACT

Introducción: Los valores de tirotropina (TSH) pueden modificarse marcadamente durante el embarazo, en relación con diversos factores clínicos y bioquímicos. Objetivo: Identificar los factores clínicos y bioquímicos asociados con la tirotropina en embarazadas aparentemente sanas. Métodos: Estudio descriptivo, transversal, con 247 gestantes aparentemente sanas del municipio Plaza de la Revolución., en el periodo comprendido de septiembre de 2015 a enero de 2019. Variables analizadas: edad materna y gestacional, trimestre del embarazo, color de la piel, paridad, hábito de fumar, antecedentes familiares de enfermedad tiroidea (APF), consumo de suplementos con yodo, índice de masa corporal (IMC), presencia de bocio al examen físico, TSH, tiroxina total (T4t) y libre (T4l), triyodotironina total (T3t) y libre (T3l), gonadotropina coriónica (hCG), anticuerpos contra la peroxidasa tiroidea (AcTPO) y la tiroglobulina (AcTg) y yoduria. Resultados: La TSH (1,66 ± 0,91mUI/L) tuvo una asociación negativa con la edad materna (r = -0,17; p = 0,008), la paridad (nulíparas 1,80 ± 0,90 mUI/L, multíparas 1,45 ± 0,89 mUI/L; p = 0,003), los APF (positivos 1,56 ± 0,91 mUI/L, negativos 1,81 ± 0,89 mUI/L; p = 0,03), la T4t (r = -0,15; p = 0,02), la T4l (r = -0,23; p = 0,000) y la hCG (r = -0,52; p = 0,001). Mostraron una relación directa la edad gestacional (r = 0,25; p = 0,000) y el uso de suplementos yodados (consumo 1,96 ± 0,72mUI/L, no consumo 1,62 ± 0,93 mUI/L; p = 0,03). Conclusiones: La tirotropina presenta una relación inversa con la edad materna, la paridad, los antecedentes familiares de enfermedad tiroidea, la T4 total y libre, y la gonadotropina coriónica, y una relación directa con la edad gestacional y el consumo de suplementos con yodo(AU)


Introduction: Thyrotropin (TSH) values can be sharply modified during pregnancy, in relation to various clinical and biochemical factors. Objective: Identify clinical and biochemical factors associated with thyrotropin in seemingly healthy pregnant women. Methods: Descriptive, cross-sectional study with 247 seemingly healthy pregnant women from Plaza de la Revolution municipality in the period from September 2015 to January 2019. Variables analyzed: maternal and gestational age, trimester of pregnancy, skin color, pregnancies, smoking habit, family history of thyroid disease (APF), consumption of iodine supplements, body mass index (BMI), presence of goiter to physical examination, TSH, total and free (T4l) thyroxine (T4t), total (T3t) and free (T3l) triiodothyronine, chorionic gonadotropin (hCG), antibodies against thyroid peroxidase (AcTPO) and thyroglobulin (AcTg) and urinary iodine. Results: TSH (1.66 ± 0.91mUI/L) had a negative association with maternal age (r = -0.17; p x 0.008), pregnancy (nulliparas 1.80 ± 0.90 mUI/L, 1.45 ± 0.89 mUI/L; p x 0.003), APF (positive 1.56 ± 0.91 mUI/L, negative 1.81 ± 0.89 mUI/L; p x 0.03), the T4t (r = -0.15; p s 0.02), the T4l (r = -0.23; p x 0.000) and the hCG (r = -0.52; p x 0.001). They showed a direct relationship with gestational age (r x 0.25; p x 0.000) and the use of iodine supplements (consumption 1.96 ± 0.72mUI/L, not consumption 1.62 ± 0.93 mUI/L; p x 0.03). Conclusions: Thyrotropin has an inverse relationship with maternal age, pregnancies, family history of thyroid disease, total and free T4, and chorionic gonadotropin, and a direct relationship with gestational age and consumption of iodine supplements(AU)


Subject(s)
Humans , Female , Pregnancy , Adult , Thyroid Diseases/etiology , Thyrotropin/administration & dosage , Body Mass Index , Gestational Age , Goiter/etiology , Epidemiology, Descriptive , Cross-Sectional Studies , Maternal Age , Observational Studies as Topic
16.
Rev. bras. ginecol. obstet ; 42(11): 752-758, Nov. 2020. tab, graf
Article in English | LILACS | ID: biblio-1144179

ABSTRACT

Abstract Objective: To identify whether the effects of thyroid disease during pregnancy and lactation affect the nutritional composition of human milk. Methods: Systematic review of the scientific literature using the Medical Literature Analysis and Retrieval System Online/MedLine databases to evaluate the association of thyroid diseases during pregnancy and lactation with the nutritional composition of human milk. There was no delimitation by period or by language, and the searches were completed in March 2019. The following descriptors were applied: human milk AND thyroid AND composition, using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) protocol for data search, selection, and extraction. The flowchart proposed for bibliographic search resulted in 12 articles and, of these, four were selected. Results: The articles elected for this review were published between 1976 and 2018. Two studies found significant differences in the nutritional composition of mothers' milk with hypothyroidism or overweight compared with the milk of those without hypothyroidism. Studies have shown that the presence of the disease led to changes in the nutritional composition of human milk, especially a higher concentration of human milk fat. Conclusion: It is extremely important that these women have continuous nutritional follow-up to minimize the impact of these morbidities on the nutritional composition of human milk.


Resumo Objetivo: Identificar se os efeitos da doença da tireoide durante a gestação e lactação afetam a composição nutricional do leite humano. Métodos: Revisão sistemática da literatura científica por meio das bases de dados Medical Literature Analysis and Retrieval System Online/MedLine a fim de avaliar a associação das doenças da tireoide na gestação e na lactação com a composição nutricional do leite humano. Não houve delimitação por período nem por idioma, e as buscas foram finalizadas em março de 2019. Foram aplicados os seguintes descritores: human milk AND thyroid AND composition, utilizando protocolo preferred reporting items for systematic reviews and meta-analyses (PRISMA) para a busca, seleção e extração de dados. De acordo com o fluxograma proposto, a busca bibliográfica resultou em 12 artigos e, destes, quatro foram selecionados. Resultados: Os artigos elegidos para a presente revisão foram publicados entre 1976 e 2018. Dois estudos verificaram diferenças significativas na composição nutricional do leite de mães com hipotireoidismo ou excesso de peso em comparação ao grupo controle sem hipotireoidismo. Os estudos demonstraram que a presença da doença levava a modificações na composição nutricional do leite humano, principalmente em relação à maior concentração da gordura. Conclusão: É de extrema importância que essas mulheres tenham acompanhamento nutricional contínuo a fim de minimizar o impacto dessas morbidades sobre a composição nutricional do leite humano.


Subject(s)
Humans , Female , Pregnancy , Puerperal Disorders , Thyroid Diseases , Lactation , Milk, Human/chemistry
17.
Rev. Hosp. Ital. B. Aires (2004) ; 40(3): 95-104, sept. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1128985

ABSTRACT

La relación entre inmunidad y cáncer es compleja. Las células tumorales desarrollan mecanismos de evasión a las respuestas del sistema inmunitario. Esta capacidad permite su supervivencia y crecimiento. La inmunoterapia ha transformado el tratamiento oncológico mejorando la respuesta inmunitaria contra la célula tumoral. Esta se basa en el bloqueo de los puntos de control inmunitario mediante anticuerpos monoclonales contra la molécula inhibidora CTLA-4 (antígeno 4 del linfocito T citotóxico [CTLA-4]) y la proteína 1 de muerte celular programada y su ligando (PD-1/PD-L1). Aunque los inhibidores de los puntos de control inmunitario (ICIs) son fármacos bien tolerados, tienen un perfil de efectos adversos conocido como eventos adversos inmunorrelacionados (EAI). Estos afectan varios sistemas, incluyendo las glándulas endocrinas. Los eventos adversos endocrinos más frecuentes son la disfunción tiroidea, la insuficiencia hipofisaria, la diabetes mellitus autoinmune y la insuficiencia suprarrenal primaria. El creciente conocimiento de estos efectos adversos endocrinos ha llevado a estrategias de tratamiento efectivo con el reemplazo hormonal correspondiente. El objetivo de esta revisión es reconocer la incidencia de estas nuevas endocrinopatías, la fisiopatología, su valoración clínica y el manejo terapéutico. (AU)


The relationship between immunity and cancer is complex. Tumor cells develop evasion mechanisms to the immune system responses. This ability allows their survival and progression. Immunotherapy has transformed cancer treatment by improving the immune response against tumor cells. This is achieved by blocking immune checkpoints with monoclonal antibodies against cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 and its ligand (PD-1 / PD-L1). Although the immune checkpoint inhibitors (ICIs) are well tolerated drugs, they have a profile of adverse effects known as immune-related adverse events (irAES). These involve diverse systems, including the endocrine glands. The most frequent endocrine immune-related adverse events are thyroid and pituitary dysfunction, autoimmune diabetes mellitus and primary adrenal insufficiency. The increasing knowledge of these irAES has led to effective treatment strategies with the corresponding hormonal replacement. The objective of this review is to recognize the incidence of these new endocrinopathies, the physiopathology, their clinical evaluation, and therapeutic management. (AU)


Subject(s)
Humans , Endocrine System Diseases/chemically induced , Immunotherapy/adverse effects , Thyroid Diseases/diagnosis , Thyroid Diseases/chemically induced , Thyroid Diseases/pathology , Thyroid Diseases/therapy , Thyroxine/administration & dosage , Triiodothyronine/therapeutic use , Adrenal Cortex Hormones/administration & dosage , Adrenal Insufficiency/diagnosis , Adrenal Insufficiency/chemically induced , Adrenal Insufficiency/pathology , Adrenal Insufficiency/therapy , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/chemically induced , Diabetes Mellitus, Type 1/pathology , Diabetes Mellitus, Type 1/therapy , Endocrine System Diseases/diagnosis , Endocrine System Diseases/physiopathology , Endocrine System Diseases/therapy , Hypophysitis/diagnosis , Hypophysitis/chemically induced , Hypophysitis/pathology , Hypophysitis/therapy , Glucocorticoids/administration & dosage , Insulin/therapeutic use , Methimazole/therapeutic use , Mineralocorticoids/therapeutic use , Antibodies, Monoclonal/therapeutic use , Neoplasms/immunology
18.
Rev. bras. ortop ; 55(4): 483-489, Jul.-Aug. 2020. tab
Article in English | LILACS | ID: biblio-1138048

ABSTRACT

Abstract Objective To clarify the association of thyroid disorders and primary frozen shoulder by comparing this group with controls without shoulder disease and with patients with rotator cuff tears. Methods We evaluated 166 patients who presented frozen shoulder with treatment in progress or already treated, which were compared with 129 patients with diagnosis of rotator cuff tears and 251 control subjects. All of the participants answered the questionnaire on the following variables: age, gender, body mass index (BMI), occupation, physical activity, presence of thyroid disorders and other comorbidities, smoking and use of alcohol. Results When comparing the frozen shoulder group with the control and rotator cuff groups, there is a specific association between the presence of thyroid disorders and frozen shoulder. By calculating relative risk, it is possible to state that an individual with thyropathy has 2.69 more chance of developing frozen shoulder. Also, there was an association with gender, since women with frozen shoulder exceeded significantly the risk. Conclusions Thyroid disorders, especially hypothyroidism and the presence of benign thyroid nodules, are risk factors significantly associated with frozen shoulder, rising the chances to 2.69 times of developing frozen shoulder. This is the first study that uses, in addition to the control group, a second group with rotator cuff tears, so it was shown that there is a specific association of thyroid disorders and frozen shoulder, but not with shoulder disorders in general.


Resumo Objetivo Verificar a asssociação entre tireopatias e ombro congelado primário, comparando com grupo controle e com grupo de pacientes com lesão no manguito rotador. Métodos Foram avaliados 166 pacientes com diagnóstico de ombro congelado primário com tratamento em andamento ou já tratados. Este grupo foi comparado com 129 pacientes com diagnóstico de lesão de manguito rotador e com um terceiro grupo controle formado por 251 indivíduos sem acometimento dos ombros. Todos os participantes responderam questionário sobre as seguintes variáveis: idade, gênero, índice de massa corpórea (IMC), profissão, atividade física, presença de tireopatia e de outras comorbidades, hábito tabagista e etilismo. Resultados Quando comparamos o grupo de ombro congelado com os grupos controle e lesão de manguito rotador, percebemos que existe uma associação específica entre presença de doenças da tireoide (tireoidite, hipotireoidismo, hipertireoidismo, nódulos e câncer) e ombro congelado. Através do cálculo do risco relativo, é possível afirmar que um indivíduo com tireopatia tem probabilidade 2.69 maior de desenvolver ombro congelado. Também houve associação com gênero, já que as mulheres com ombro congelado elevam significativamente esse risco. Conclusão Os distúrbios da tireoide, especialmente o hipotireoidismo e a presença de nódulos tireoidianos benignos, são fatores de risco significativamente associados ao ombro congelado, aumentando as chances em 2,69 vezes de desenvolver a doença. Este é o primeiro estudo que utiliza, além do grupo controle, um segundo grupo com lesões do manguito rotador, de modo que foi demonstrada uma associação específica de distúrbios da tireoide e ombro congelado.


Subject(s)
Humans , Thyroid Diseases , Bursitis , Control Groups , Hypothyroidism
19.
Braz. j. otorhinolaryngol. (Impr.) ; 86(3): 321-326, May-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1132601

ABSTRACT

Abstract Introduction: Many studies have been done on proteomics, genomics, epigenetic, immunogenetics in many body fluids. Among these, circulating cell-free DNA (ccfDNA) entered the literature in 1948, but it has not been studied for many years due to technological deficiencies. Following recent advances, geno-metastasis has been mentioned and new research is needed in this area. ccfDNA is known to be an important biomolecule in this regard. Objective: The presence of cell-free DNA in the circulatory system may offer a tremendous opportunity to provide novel biomarkers for thyroid diseases. This experimental study was conducted to determine the amount of ccfDNA in different thyroid diseases, then to evaluate whether the ccfDNA concentration varied between the disease groups and control group. Methods: In total, we included 121 individuals in the present study. We collected blood samples and then determined the ccfDNA concentration in plasma of collected blood samples from three groups: thyroiditis (n = 33), benign (n = 37), and malignant (n = 30) and from a control group (n = 21). Results: The median values of the ccfDNA groups were found as 1610, 1665, 1685 and 576 ng/mL for the thyroiditis, benign, malign, and control groups, respectively. Findings showed that the ccfDNA of the three groups was significantly higher than the control (p < 0.0001). Each group was compared in terms of ccfDNA and the p-values of benign-thyroiditis, benign-malign, and thyroiditis-malign were 0.09, 0.65, and 0.29, respectively. Conclusions: The clear differences between thyroid diseases and controls suggest that ccfDNA is worthy of attention as a biomarker for further evaluation of different thyroid diseases. Likewise, it might indicate a clear tendency that ccfDNA can also be used to distinguish different thyroid diseases.


Resumo Introdução: Muitos estudos foram realizados em proteômica, genômica, epigenética e imunogenética em vários fluidos corporais. Entre esses, o DNA circulante livre de células (cfDNA) despontou na literatura em 1948, mas não foi estudado por muitos anos devido a deficiências tecnológicas. Após recentes avanços, a genometástase é mencionada e novas pesquisas tornam-se necessárias nessa área. Nesse sentido, o cfDNA é conhecido por ser uma importante biomolécula. Objetivo: A presença de DNA livre de células no sistema circulatório pode oferecer uma excelente oportunidade para fornecer novos biomarcadores para doenças da tireoide. Este estudo experimental foi conduzido para determinar a quantidade de cfDNA em diferentes doenças da tireoide e então avaliar se a concentração de cfDNA variou entre os grupos com doença e o grupo controle. Método: No total, 121 indivíduos foram incluídos no estudo. Coletamos amostras de sangue e, em então, determinamos a concentração de cfDNA no plasma de amostras de sangue de três grupos: tireoidite (n = 33), benigno (n = 37) e maligno (n = 30) e de um grupo controle (n = 21). Resultados: As medianas dos valores dos grupos de cfDNA foram de 1.610, 1.665, 1.685 e 576 ng/mL para os grupos tireoidite, benigno, maligno e controle, respectivamente. Os achados mostraram que o cfDNA dos três grupos com doença era significativamente maior do que o do grupo controle (p < 0,0001). Cada grupo foi comparado em termos de cfDNA e os p-valores de benigno-tireoidite, benigno-maligno e tireoidite-maligno foram de 0,09, 0,65 e 0,29, respectivamente. Conclusões: Como resultado, as óbvias diferenças entre as doenças da tireoide e os controles sugerem que o cfDNA é digno de atenção como um biomarcador para avaliação adicional das diferentes doenças da tireoide. Da mesma forma, isso pode indicar uma clara tendência de que o cfDNA também pode ser utilizado para distinção das diferentes doenças da tireoide.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Thyroid Diseases/diagnosis , Thyroid Diseases/blood , Cell-Free Nucleic Acids/blood , Biomarkers/blood , Sensitivity and Specificity , Real-Time Polymerase Chain Reaction
20.
Rev. chil. pediatr ; 91(3): 379-384, jun. 2020. tab
Article in Spanish | LILACS | ID: biblio-1126175

ABSTRACT

Resumen: Introducción: El tratamiento del neuroblastoma en estadios avanzados incluye quimioterapia, cirugía y terapia con I131-Metayodo benzilguanidina (I131-MIBG). La disfunción tiroidea se reporta entre 12 y 85% a pesar de la protección tiroidea. Objetivo: Identificar la frecuencia de disfunción tiroidea en casos de neu roblastoma tratados con I131-MIBG. Pacientes y Método: Estudio transversal. Se incluyeron todos los casos con diagnóstico de neuroblastoma que recibieron I131-MIBG en el periodo de 2002-2015, a los cuales se les realizó antropometría completa, perfil de tiroides: hormona estimulante de tiroides (TSH), Triyodotironina total y libre (T3t y T3l), tiroxina total y libre (T4t, T4l), y anticuerpos antitiroglobulina y antiperoxidasa. Resultados: Se identificaron un total de 27 pacientes; once fallecieron (40%). De los 16 casos sobrevivientes, 9 (56%) presentaron disfunción tiroidea: 2 (13%) casos con hipotiroidismo subclínico y 7 (44%) casos con hipotiroidismo clínico (3 casos por retraso en el desa rrollo psicomotor y 4 por desaceleración del crecimiento). Los pacientes presentaron manifestaciones clínicas a los 16,1 meses (1,2-66,3 meses) de recibir el radiofármaco a una dosis acumulada de 142 mCi (96-391.5 mCi). No se logró evidenciar diferencias en la edad al diagnóstico, la edad al inicio del tratamiento con el I131-MIBG, la dosis acumulada del I131-MIBG y el tiempo trascurrido entre la dosis y el perfil tiroideo entre los casos con o sin disfunción tiroidea. Conclusiones: El 56% de los pacientes con neuroblastoma presentaron disfunción tiroidea. La mayoría de los casos con hipotiroidismo fue ron referidos cuando los datos de disfunción tiroidea eran clínicamente evidentes. Se propone en esta poblacion realizar perfil tiroideo semestral y valoración anual por un endocrinólogo pediatra durante los primeros 5 años posteriores al diagnóstico oncológico.


Abstract: Introduction: The treatment of advanced neuroblastoma includes chemotherapy, surgery, and radiotherapy with 131-I-Metaiodobenzylguanidine (131-I-MIBG). Despite strategies to protect thyroid function, its dysfunction is reported between 12 and 85%. Objective: To identify the frequency of thyroid dys function in cases of neuroblastoma treated with 131-I-MIBG. Patients and Method: Cross-sectional study. We included all the cases with neuroblastoma treated with 131-I-MIBG between 2002 and 2015, with complete somatometry, and complete thyroid profile (TSH, free and total T3 and T4, and anti-thyroglobulin and antiperoxidase antibodies). Results: 27 patients were identified out of which eleven died (40%). Out of the 16 surviving cases, 9 (56%) presented thyroid dysfunction: 2 (13%) cases with subclinical hypothyroidism and 7 (44%) cases with clinical hypothyroidism (3 cases due to psychomotor developmental delay and 4 due to growth deceleration). The patients presented cli nical manifestations at 16.1 months (1.2-66.3 months) after receiving the radiopharmaceutical at acumulative dose of 142 mCi (96-391.5 mCi). No differences were found in the age at diagnosis, age at the start of treatment with 131-I-MIBG, the cumulative dose of 131-I-MIBG, and the time elapsed between the dose and the thyroid profile among the cases with or without thyroid dysfunction. Con clusions: 56% of patients with neuroblastoma had thyroid dysfunction. Most of the cases with hypothyroidism were referred when thyroid dysfunction was clinically evident. A thyroid profile should be performed every 6 months, along with an annual endocrinological evaluation during the next 5 years in these patients.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Radiopharmaceuticals/adverse effects , 3-Iodobenzylguanidine/adverse effects , Hypothyroidism/etiology , Iodine Radioisotopes/adverse effects , Neuroblastoma/radiotherapy , Thyroid Diseases , Cross-Sectional Studies , Retrospective Studies , Risk Factors , Radiopharmaceuticals/therapeutic use , 3-Iodobenzylguanidine/therapeutic use , Hypothyroidism/diagnosis , Hypothyroidism/epidemiology , Iodine Radioisotopes/therapeutic use
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