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1.
Int. braz. j. urol ; 47(1): 45-45, Jan.-Feb. 2021.
Article in English | LILACS | ID: biblio-1134332
2.
Rev. gaúch. enferm ; 42: e20200396, 2021.
Article in English | LILACS, BDENF | ID: biblio-1347561

ABSTRACT

ABSTRACT Objective To describe the knowledge translation obtained through research of low-level laser therapy to wound treatment in the clinical practice. Methods Experience report about implementation strategies of this new technology in a university hospital, being an extension course the main one, developed between May and December 2019. Results The course was carried out by researchers in partnership with clinical nurses to 13 nurses from different areas with previous experience in wound care. Were taught 30 theoretical-practical class hours, part of them supervised in a real clinical setting, besides case studies. From that, an exclusive nursing consultation schedule of laser therapy was created at the outpatient and its use was also improved to patients admitted in several units of the hospital. Final considerations The knowledge translation developed about laser therapy allowed its implementation as a technology in wound treatment, qualifying the professional practice and benefiting the treatment of patients with wounds.


RESUMEN Objetivo Describir la traslación del conocimiento obtenido en investigación de la terapia con láser de baja potencia para el tratamiento de heridas en la práctica clínica. Métodos Relato de experiencia sobre estrategias para la implementación de esta nueva tecnología en un hospital universitario, con un curso de extensión desarrollado entre mayo y diciembre/2019. Resultados El curso fue realizado por investigadores en alianza con enfermeras especializadas para 13 enfermeros de diferentes áreas y experiencias en el cuidado con heridas. Fueran dados 30 horas de clases teórico-prácticas supervisadas en un entorno clínico real y estudios de casos. En consecuencia de esto, se creó consultas de enfermería de terapia láser, así como un aumento de esta terapia para los pacientes hospitalizados. Consideraciones finales La transferencia de conocimiento sobre la terapia con láser permitió la implantación de esta tecnología en el tratamiento de heridas, con práctica profesional calificada y beneficio el tratamiento de pacientes con heridas.


RESUMO Objetivo Descrever a translação do conhecimento obtido em pesquisa sobre terapia a laser de baixa potência para o tratamento de feridas na prática clínica. Métodos Relato de experiência sobre estratégias de implementação dessa nova tecnologia em um hospital universitário, sendo um curso de extensão a principal delas, desenvolvido entre maio e dezembro/2019. Resultados O curso foi realizado por pesquisadores em parceria com enfermeiros assistenciais para 13 enfermeiros de diferentes áreas e experiências no cuidado a pacientes com feridas. Foram ministradas 30 horas de aulas teórico-práticas, parte das mesmas supervisionadas em cenário clínico real, além de estudos de caso. A partir disso, foi criada uma agenda de consulta de enfermagem de laserterapia no ambulatório, bem como incrementado essa terapia em pacientes hospitalizados. Considerações finais A translação do conhecimento sobre laserterapia permitiu a implantação dessa tecnologia no tratamento de feridas, qualificando a prática profissional e beneficiando o tratamento de pacientes com feridas.


Subject(s)
Humans , Professional Practice , Wound Healing , Wounds and Injuries/therapy , Low-Level Light Therapy , Nursing Care , Health Strategies , Translational Medical Research , Hospitals, University
3.
Medicina (B.Aires) ; 80(supl.3): 42-44, June 2020.
Article in Spanish | LILACS | ID: biblio-1135190

ABSTRACT

La Red de Investigación Traslacional en Salud del CONICET está coordinando esfuerzos para avanzar en la medicina traslacional. Los investigadores en salud comienzan y dirigen sus investigaciones con el objetivo de mejorar la salud y calidad de vida de la población. Un sistema de investigación eficiente debe abordar los problemas de salud de importancia para las poblaciones y las intervenciones y resultados que los pacientes y los profesionales de la salud consideren importantes. Las recomendaciones tienen que ver con grandes grupos temáticos que son (a) explicitar la relevancia de la investigación y, por tanto, sus prioridades (b) mejorar la metodología de investigación (c) transparentar la gestión y regulación de la investigación (d) aumentar la accesibilidad a todos los resultados relevantes, y (e) mejorar la manera en que se difunde la investigación. La reciente pandemia de COVID-19 ha sido una clara demostración de cómo el sistema de investigación del país ha unido las más diversas disciplinas para, en forma conjunta, brindar soluciones para enfrentarla. La reciente experiencia consolida que haya un mecanismo activo y transparente de identificación de prioridades en el país y la unión de esfuerzos de financiamiento y de investigadores en brindar soluciones a dichas prioridades. La investigación traslacional en salud significa el trabajo mancomunado de las más diversas disciplinas de investigación en salud para, en forma conjunta, obtener intervenciones eficaces y efectivas que impacten en la mejoría de la salud y la calidad de vida de la población.


CONICET's Translational Health Research Network is coordinating efforts to advance in translational medicine. Health researchers initiate and focus their research with the aim of improving the health and quality of life of the population. An efficient research system should address health problems relevant to the population resulting in interventions and outcomes important for patients and health professionals. Recommendations to achieve this involve large thematic areas like (a) to set research priorities; (b) to improve research methodology; (c) to make research management and regulation transparent; (d) to increase accessibility to all results; and (e) to improve research dissemination. The recent COVID-19 pandemic has been a clear demonstration of how the country's research system has united the most diverse disciplines to jointly provide solutions to address it. An active and transparent mechanism to identify priorities in the country and to unite funding and research efforts to provide solutions to those priorities is proposed. Translational health research means the joint work of the most diverse health research disciplines in order to jointly obtain efficient and effective interventions to improve the health and quality of life of the population.


Subject(s)
Humans , Pneumonia, Viral/epidemiology , Coronavirus Infections/epidemiology , Coronavirus , Translational Medical Research , Pandemics , Argentina/epidemiology , Quality of Life , Betacoronavirus , SARS-CoV-2 , COVID-19
4.
Rev. cuba. invest. bioméd ; 39(2): e597, abr.-jun. 2020.
Article in Spanish | LILACS, CUMED | ID: biblio-1126606

ABSTRACT

Introducción: la investigación traslacional es una rama de la ciencia de reciente creación, su objetivo principal es la aplicación del conocimiento que se genera de las investigaciones, que no quede formando parte de la literatura gris, en el papel o para unos pocos, sino que pueda servir a la mayor cantidad posible de individuos y/o poblaciones. Objetivo: determinar los avances que se han dado a lo largo de los últimos años en la aplicación de la medicina traslacional en Perú. Métodos: se realizó una búsqueda por conveniencia en bases de datos (Google Scholar, Pubmed). Se han brindado ejemplos de cómo la investigación traslacional en Perú puede aportar en gran medida a la mejora de realidades y problemáticas específicas, esto refuerza la necesidad de que las decisiones políticas deben basarse en la medicina basada en la evidencia. Resultados: la medicina traslacional en Perú enfrenta muchas dificultades, como lo son los recursos limitados, tiempo escaso para implementar la investigación formativa, carencia de modelos pedagógicos actualizados, docentes preparados en escuelas antiguas y con capacidad limitada para la educación médica continua; obstáculos que deben de superarse para poder asegurar que la ciencia -y por ende la sociedad- progresen. Conclusiones: en Perú, el avance de la medicina traslacional ha derivado en la generación de personal de salud más capacitado que ha proporcionado los medios para el desarrollo de múltiples políticas públicas. Dichas políticas en muchos casos han terminado plasmadas en normas, reglamentos y hasta leyes en el país(AU)


Introduction: translational research is a branch of science of recent creation. Its main aim is the application of the knowledge generated by research so that it will not become grey literature printed on paper or for the use of a chosen few, but serve as many people and/or populations as possible. Objective: determine the progress made in recent years in the application of translational medicine in Peru. Methods: a convenience search was conducted in the databases Google Scholar and PubMed. Examples are offered of the way in which translational research may greatly contribute to improve specific realities and problems in Peru. This reinforces the need that political decisions be based on evidence-based medicine. Results: translational medicine is faced with many difficulties in Peru, such as limited resources, scant time to implement training research, lack of updated pedagogical models, and teachers trained in old schools and with a limited capacity for continuing medical education. These hurdles should be overcome to ensure the progress of science and therefore of society as well. Conclusions: progress of translational medicine in Peru has resulted in the training of more skilled health personnel, providing the means for the development of multiple public policies. In many cases those policies have been included in standards, regulations and even laws in the country(AU)


Subject(s)
Humans , Education, Medical, Continuing , Translational Medical Research/education , Translational Medical Research/methods , Peru , Gray Literature , Malaria/prevention & control
5.
RECIIS (Online) ; 14(1): 225-246, jan.-mar. 2020. ilus
Article in Portuguese | LILACS | ID: biblio-1087311

ABSTRACT

O uso dos resultados da pesquisa e do conhecimento bem como a aplicação das descobertas científicas no mundo real não ocorrem de forma natural. Instituições acadêmicas e governos têm definido que a translação da pesquisa é uma prioridade para a saúde: as evidências científicas devem embasar as decisões para melhorar a saúde. Porém, a lacuna entre ciência e prática, os entraves naturais e criados entre elas mostram que a translação do conhecimento é um processo que precisa ser implementado. As formas de fazê-lo requerem atitudes do meio acadêmico e do ambiente político e de gestão, algo complexo e de difícil solução. Este artigo busca compreender o tema por meio da leitura de autores da área de saúde. Detémse com especial atenção na conceituação e nos modelos disponíveis, além de analisar como se dá essa passagem de evidências entre o campo da ciência e os responsáveis pelas tomadas de decisão e como estas são utilizadas.


The use of research results and knowledge as well as the application of scientific discoveries in the real world do not occur naturally. Academic institutions and governments have defined that the research translation is a priority for health: decisions should be based on scientific evidence to improve health. However, the gap between science and practice, the natural and created barriers between them show that the knowledge translation is a process that has to be implemented. The ways to do it involve attitudes in both academic, managerial and political environment, which are a issue quite complex and difficult to solve. This paper proposes to understand the topic by reading some authors of the health field. We give a special attention to the concepts, the available models and we analyze how the exchange of evidence between science and decision makers takes place and how the evidence is used.


El uso de los resultados de la investigación y el conocimiento, así como la aplicación de descubrimientos científicos en el mundo real, no ocurren naturalmente. Instituciones académicas y gobiernos han definido que la traslación de la investigación es una prioridad para la salud: las evidencias científicas deben respaldar las decisiones para mejorar la salud. Sin embargo, el intervalo entre ciencia y práctica, los obstáculos naturales y creados entre ellas muestran que la traslación del conocimiento es un proceso que necesita ser implementado. Las formas de hacerlo implican actitudes del medio académico y del ambiente político y de gestión, algo complejo y de difícil solución. Este artículo propone entender el tema por medio de la lectura de autores del área de salud. Nos detenemos en la conceptualización, los modelos, y analizamos la manera de intercambiar evidencias entre el campo de la ciencia y los responsables de la toma de decisiones y el modo como estas son usadas.


Subject(s)
Humans , Knowledge , Access to Information , Decision Making , Scientific Research and Technological Development , Translational Medical Research , Information Dissemination , Evidence-Informed Policy , Health Policy
6.
Rev. Hosp. Ital. B. Aires (2004) ; 40(1): 17-24, mar. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1100762

ABSTRACT

Se estima que aproximadamente 100 trillones de microorganismos (incluidos bacterias, virus y hongos) residen en el intestino humano adulto y que el total del material genético del microbioma es 100 veces superior al del genoma humano. Esta comunidad, conocida como microbioma se adquiere al momento del nacimiento a través de la flora comensal de la piel, vagina y heces de la madre y se mantiene relativamente estable a partir de los dos años desempeñando un papel crítico tanto en el estado de salud como en la enfermedad. El desarrollo de nuevas tecnologías, como los secuenciadores de próxima generación (NGS), permiten actualmente realizar un estudio mucho más preciso de ella que en décadas pasadas cuando se limitaba a su cultivo. Si bien esto ha llevado a un crecimiento exponencial en las publicaciones, los datos sobre las poblaciones Latinoamérica son casi inexistentes. La investigación traslacional en microbioma (InTraMic) es una de las líneas que se desarrollan en el Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB). Esta se inició en 2018 con la línea de cáncer colorrectal (CCR) en una colaboración con el Colorectal Cancer Research Group del Leeds Institute of Medical Research en el proyecto Large bowel microbiome disease network: Creation of a proof of principle exemplar in colorectal cancer across three continents. A fines de 2019 se cumplió el objetivo de comprobar la factibilidad de la recolección, envío y análisis de muestras de MBF en 5 continentes, incluyendo muestras provenientes de la Argentina, Chile, India y Vietnam. Luego de haber participado de capacitaciones en Inglaterra, se ha cumplido con el objetivo de la etapa piloto, logrando efectivizar la recolección, envío y análisis metagenómico a partir de la secuenciación de la región V4 del ARNr 16S. En 2019, la línea de enfermedad de hígado graso no alcohólico se sumó a la InTraMic iniciando una caracterización piloto en el marco de una colaboración con el laboratorio Novartis. Los resultados de ese estudio, así como el de cáncer colorrectal, están siendo enviados a publicación. En 2020, con la incorporación de la línea de trasplante alogénico de células progenitoras hematopoyéticas, fue presentado un proyecto para un subsidio del CONICET que ha superado la primera etapa de evaluación. En el presente artículo se brinda una actualización sobre la caracterización taxonómica de microbioma y se describen las líneas de investigación en curso. (AU)


It is estimated that approximately 100 trillion microorganisms (including bacteria, viruses, and fungi) reside in the adult human intestine, and that the total genetic material of the microbiome is 100 times greater than that of the human genome. This community, known as the microbiome, is acquired at birth through the commensal flora of the mother's skin, vagina, and feces and remains relatively stable after two years, playing a critical role in both the state of health and in disease. The development of new technologies, such as next-generation sequencers (NGS), currently allow for a much more precise study of it than in past decades when it was limited to cultivation. Although this has led to exponential growth in publications, data on Latin American populations is almost non-existent. Translational research in microbiome (InTraMic) is one of the lines developed at the Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB). This started in 2018 with the Colorectal Cancer Line (CRC) in a collaboration with the Colorectal Cancer Research Group of the Leeds Institute of Medical Research in the project "Large bowel microbiome disease network: Creation of a proof of principle exemplar in colorectal cancer across three continents". At the end of 2019, the objective of verifying the feasibility of collecting, sending and analyzing MBF samples on 5 continents, including samples from Argentina, Chile, India and Vietnam, was met. After having participated in training in England, the objective of the pilot stage has been met, achieving the collection, delivery and metagenomic analysis from the sequencing of the V4 region of the 16S rRNA. In 2019, the non-alcoholic fatty liver disease line joined InTraMic, initiating a pilot characterization in the framework of a collaboration with the Novartis laboratory. The results of that study, as well as that of colorectal cancer, are being published. In 2020, with the incorporation of the allogeneic hematopoietic stem cell transplantation line, a project was presented for a grant from the CONICET that has passed the first stage of evaluation. This article provides an update on the taxonomic characterization of the microbiome and describes the lines of ongoing research. (AU)


Subject(s)
Humans , Translational Medical Research/organization & administration , Gastrointestinal Microbiome/genetics , Transplantation, Homologous , Vietnam , Aztreonam/therapeutic use , RNA, Ribosomal, 16S/analysis , Colorectal Neoplasms/genetics , Colorectal Neoplasms/microbiology , Colorectal Neoplasms/epidemiology , Classification/methods , Hematopoietic Stem Cell Transplantation , Metagenomics , Translational Medical Research/methods , High-Throughput Nucleotide Sequencing/trends , Non-alcoholic Fatty Liver Disease/genetics , Non-alcoholic Fatty Liver Disease/microbiology , Non-alcoholic Fatty Liver Disease/pathology , Non-alcoholic Fatty Liver Disease/epidemiology , Gastrointestinal Microbiome/physiology , India , Latin America , Occult Blood
7.
Rev. cuba. enferm ; 36(1): e2907, graf
Article in Spanish | LILACS, BDENF, CUMED | ID: biblio-1280244

ABSTRACT

Introducción: El vacío entre lo que se sabe y lo que se hace es complejo para la toma de decisiones ante las demandas de la práctica diaria de atención a la salud de las personas, familias y comunidades. En ese sentido, la traducción del conocimiento puede ser una estrategia de transformación del conocimiento en acción con la participación del usuario del sistema de salud. Objetivo: Reflexionar acerca del significado, las potencialidades y límites de aplicación del modelo conceptual conocimiento en acción de la estrategia de traducción del conocimiento para transferir conocimientos científicos al campo de la salud y la enfermería. Métodos: Análisis teórico-reflexivo del modelo conceptual de traducción del conocimiento en acción, editado por expertos del área de la salud, de acuerdo con la definición del Instituto Canadiense de Investigación en Salud y adoptado por la OMS y EVIPNET, con aplicación en países latinoamericanos. Esa reflexión fue dividida en tres ejes: significado; modelo conceptual y aplicación en la práctica. Conclusiones: Algunas propuestas de transformación del conocimiento en acción y justicia social han empezado a considerarse en América Latina, tanto en la política como en la práctica clínica. En el campo de la enfermería hay una creciente aplicación del modelo de traducción del conocimiento a la acción, con la utilización de diferentes enfoques de investigación para integrar a los participantes para la producción de nuevas prácticas más eficiente, efectiva, eficaz y segura(AU)


Introduction: The gap between what is known and what is done is complex for decision-making in the face of daily-practice demands of the healthcare of individuals, families and communities. In that respect, knowledge translation can be a strategy of knowledge transformation in action with the participation of the health system user. Objective: To reflect on the meaning, potentialities and limits of applying the conceptual model knowledge in action of the knowledge translation strategy to transfer scientific knowledge to the field of health and nursing. Methods: Theoretical-reflexive analysis of the conceptual model of translation of knowledge in action, edited by experts in the health area​​, in accordance with the definition of the Canadian Institutes for Health Research and adopted by WHO and EVIPNET, with application in Latin American countries. That reflection was divided into three axes: meaning, conceptual model, and application in practice. Conclusions: Some proposals for the transformation of knowledge into action and social justice have started to be considered in Latin America, both in politics and in clinical practice. In the field of nursing, there is a growing application of the model of translation of knowledge into action, with the use of different research approaches to integrate participants for the production of new practices that are more efficient, effective, and safer(AU)


Subject(s)
Humans , Delivery of Health Care/methods , Evidence-Based Practice , Translational Medical Research/methods , Decision Making
9.
Article in English | WPRIM | ID: wpr-785393

ABSTRACT

Methods for reproducibly isolating and enriching small extracellular vesicles (EVs) from blood are essential for clinical utilization of small EVs in cancer patients. We combined ultracentrifugation (UC) with polymer-based precipitation (ExoQuick [EQ] or Total Exosome Isolation [TEI] kit) to isolate small EVs (diameter, 30–150 nm) from the serum of breast cancer patients. We compared the performance of four cycles of UC (UC4x) with that of two cycles of UC followed by enrichment using the EQ (UC2x→EQ) or TEI (UC2x→TEI) kits. The mean concentration of small EVs isolated from 1 mL of serum using UC2x→EQ (139.0±29.1 µg) and UC2x→TEI (140.4±5.0 µg) did not differ from that obtained using UC4x (141.8±26.9 µg). The mean number of EV particles obtained using UC4x was 29.2±9.9×109 per mL of serum, whereas UC2x→EQ and UC2x→TEI yielded higher numbers of EVs (50.7±17.0×10⁹ and 59.3±20.6×10⁹, respectively). Concentrations of EV microRNAs, including miR-21 and miR-155, did not differ between the three methods. In conclusion, performing UC prior to the use of polymer-based precipitation kits could be feasible for isolating small EVs from human serum in large sample-based translational researches.


Subject(s)
Breast Neoplasms , Extracellular Vesicles , Humans , MicroRNAs , Translational Medical Research , Ultracentrifugation
10.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-827023

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
11.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-828750

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
12.
Protein & Cell ; (12): 707-722, 2020.
Article in English | WPRIM | ID: wpr-828586

ABSTRACT

The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS-CoV-2-infected patients with severe pneumonia rapidly develop acute respiratory distress syndrome (ARDS) and die of multiple organ failure. Despite advances in supportive care approaches, ARDS is still associated with high mortality and morbidity. Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. By releasing a variety of paracrine factors and extracellular vesicles, MSC can exert anti-inflammatory, anti-apoptotic, anti-microbial, and pro-angiogenic effects, promote bacterial and alveolar fluid clearance, disrupt the pulmonary endothelial and epithelial cell damage, eventually avoiding the lung and distal organ injuries to rescue patients with ARDS. An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. Since low cell engraftment and survival in lung limit MSC therapeutic potentials, several strategies have been developed to enhance their engraftment in the lung and their intrinsic, therapeutic properties. Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS.


Subject(s)
Adoptive Transfer , Alveolar Epithelial Cells , Pathology , Animals , Apoptosis , Betacoronavirus , Body Fluids , Metabolism , CD4-Positive T-Lymphocytes , Allergy and Immunology , Clinical Trials as Topic , Coinfection , Therapeutics , Coronavirus Infections , Allergy and Immunology , Disease Models, Animal , Endothelial Cells , Pathology , Extracorporeal Membrane Oxygenation , Genetic Therapy , Methods , Genetic Vectors , Therapeutic Uses , Humans , Immunity, Innate , Inflammation Mediators , Metabolism , Lung , Pathology , Mesenchymal Stem Cell Transplantation , Methods , Mesenchymal Stem Cells , Physiology , Multiple Organ Failure , Pandemics , Pneumonia, Viral , Allergy and Immunology , Respiratory Distress Syndrome , Allergy and Immunology , Pathology , Therapeutics , Translational Medical Research
13.
Blood Research ; : 1-9, 2020.
Article in English | WPRIM | ID: wpr-820809

ABSTRACT

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study aimed to investigate AML research networks and to conduct a trend-related keyword analysis. We analyzed 48,202 studies about AML published from 1999 to 2019 in the Web of Science Core Collection. The network analysis was conducted using the R&R studio software. The journal Blood had the highest number of published articles with an h-index of 410. The USA had the highest number of total publications (18,719, 38.3%) and research funded by the government, institutions, and pharmaceutical companies (5,436, 10.8%). The institute with the largest number of publications was the MD Anderson Cancer Center. Kantarjian H, Garcia-Manero G, and Ravandi F were the leading authors of publications about AML. Keyword analysis revealed that FLT 3, micro-RNA, and NK cell topics were the hotspots in the cell and gene area in all publications. The overall AML research landscape is popular in the field of translational research as it can identify molecular, cell, and gene studies conducted by different funding agencies, countries, institutions, and author networks. With active funding and support from the Chinese government, the productivity of scientific research is increasing not only in the AML field but also in the medical/health-related science field.


Subject(s)
Asian Continental Ancestry Group , Bibliometrics , Efficiency , Financial Management , Humans , Killer Cells, Natural , Leukemia, Myeloid, Acute , Publications , Translational Medical Research
14.
Rev. saúde pública (Online) ; 54: 72, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1127230

ABSTRACT

ABSTRACT The term knowledge translation has been used to describe the process of applying research results to the real world, in order to enhance the quality and effectiveness of health care and services. The aim of this article is to discuss the incorporation of knowledge translation in the Brazilian public health. The article addresses the basic activities of knowledge translation and lists challenges and perspectives in Brazilian scenario. Brazil began to move towards understanding the process of translating scientific knowledge into practice. Investing in pilot studies to adapt the so-called effective interventions to the Brazilian scenario may be an alternative. Increasing the qualification of Brazilian researchers in the design and evaluation of implementation studies is relevant to improve this field in the country.


RESUMO O termo tradução do conhecimento tem sido utilizado para descrever o processo de aplicar os resultados de pesquisa no mundo real, com o intuito de potencializar a qualidade e a eficácia dos serviços e cuidados de saúde. O objetivo deste artigo é discutir a incorporação da tradução do conhecimento na saúde pública do Brasil. No artigo, aborda-se as atividades básicas da tradução do conhecimento e elenca-se desafios e perspectivas no cenário brasileiro. O Brasil começou a caminhar no entendimento do processo de traduzir o conhecimento científico para a prática. Investir em estudos pilotos para adaptar intervenções efetivas, assim rotuladas em outros países, para o cenário brasileiro pode ser uma alternativa. Aumentar a capacitação de pesquisadores brasileiros no delineamento e avaliação de estudos de implementação é relevante para a melhoria deste campo no País.


Subject(s)
Humans , Public Health , Delivery of Health Care/organization & administration , Translational Medical Research , Brazil
15.
Rev. cuba. enferm ; 35(4): e2907, oct.-dic. 2019. graf
Article in Spanish | LILACS, BDENF, CUMED | ID: biblio-1251703

ABSTRACT

Introducción: El vacío entre lo que se sabe y lo que se hace es complejo para la toma de decisiones ante las demandas de la práctica diaria de atención a la salud de las personas, familias y comunidades. En ese sentido, la traducción del conocimiento puede ser una estrategia de transformación del conocimiento en acción con la participación del usuario del sistema de salud. Objetivo: Reflexionar acerca del significado, las potencialidades y límites de aplicación del modelo conceptual conocimiento en acción de la estrategia de traducción del conocimiento para transferir conocimientos científicos para el campo de la salud y enfermería. Métodos: Análisis teórico-reflexivo del modelo conceptual de traducción del conocimiento en acción, editado por expertos del área de la salud, de acuerdo con la definición del Instituto Canadiense de Investigación en Salud y adoptado por la OMS y EVIPNET, con aplicación en países latinoamericanos. Esa reflexión fue dividida en tres ejes: significado; modelo conceptual y aplicación en la práctica. Conclusiones: Algunas propuestas de transformación del conocimiento en acción y justicia social han empezado a considerarse en América Latina, tanto en la política como en la práctica clínica. En el campo de la enfermería hay una creciente aplicación del modelo de traducción del conocimiento a la acción, con la utilización de diferentes enfoques de investigación para integrar a los participantes para la producción de nuevas prácticas más eficiente, efectiva, eficaz y segura.(AU)


Introduction: The gap between what is known and what is done makes decision making very complex in front of the daily demands of the health care practice of individuals, families and communities. In this sense, the Knowledge Translation can be a strategy for transforming knowledge into action with the participation of the user of the health system. Objective: present the meaning of Knowledge Translation; describe the model of Knowledge Translation for the transformation of knowledge into action; reflect on the potentialities and limits of application of this model in the transfer of knowledge for health area and nursing practice. Methods: theoretical-reflexive analysis of the conceptual model of knowledge translation into action, edited by health experts, according to the definition of the Canadian Institute of Health Research and adopted by the WHO and EVIPNET, with application in Latin American countries. That reflection was divided into three axes: meaning; conceptual model; and application in practice. Conclusions: Some proposals for the transformation of knowledge into action and social justice have begun to be considered in Latin America, be it in politics or in clinical practice. In the field of Nursing, there is a growing application of the translation model of knowledge in action, with the use of different research approaches to integrate participants for the production of new practices more efficient, effective, efficacious and safe(AU)


Subject(s)
Humans , Delivery of Health Care/methods , Evidence-Based Practice/methods , Translational Medical Research , Decision Making
16.
Rev. cienc. salud (Bogotá) ; 17(3): 111-131, dic. 2019. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1058225

ABSTRACT

Resumen Introducción: Las brechas entre la investigación en salud y su aplicación práctica constituyen un objeto de estudio y un campo de intervención en la esfera sanitaria. La traducción y uso del conocimiento basado en investigación se consideran cruciales para mejorar la salud pública y los sistemas de salud. Desarrollo: El objetivo de este trabajo es revisar y comparar los enfoques conceptuales investigación traslacional (trans-lational research), traslación del conocimiento (knowledge translation) y movilización del conocimiento (knowledge mobilization). Estos enfoques se han desarrollado teórica e institucionalmente en países con fuertes sistemas de investigación en salud, como Estados Unidos, Canadá y Reino Unido, mientras que en Latinoamérica han sido poco trabajados. Se identifican sus objetivos, concepción de los procesos de transferencia de conocimiento, principales aportes y limitaciones. El enfoque movilización del conocimiento en salud se destaca como una propuesta más amplia, que aborda el carácter social de la producción, transferencia y uso del conocimiento. Conclusiones: El enfoque de movilización de conocimiento puede ser un marco útil para el estudio y sistematización de experiencias sobre el uso del conocimiento en salud en la región latinoamericana, a fin de fortalecer los sistemas nacionales de investigación en salud.


Abstract Introduction: The gaps between health research and its practical application constitute an object of study and a field of intervention in the health sphere. The translation and use of research-based knowledge are considered crucial to improve public health and health systems. Development: The aim of this paper is to review and compare the conceptual approaches translational research, knowledge translation, and knowledge mobilization. These approaches have been theoretically and institutionally developed in countries with strong health research systems such as the United States, Canada, and the United Kingdom, while in Latin America, they have not been sufficiently studied. To analyze the knowledge transfer processes conception and their main contributions and limitations. The knowledge mobilization approach stands out as a wider framework, which includes the social nature of the production, transfer, and use of knowledge. Conclusions: The knowledge mobilization approach is a suitable framework for studying and systematizing experiences on the use of health knowledge in Latin America, aiming at strengthening National Health Research Systems.


Resumo Introdução: As brechas entre a pesquisa em saúde e a sua aplicação prática constituem um objeto de estudo e um campo de intervenção na esfera sanitária. A tradução e uso do conhecimento baseado em pesquisa consideram-se cruciais para melhorar a saúde pública e os sistemas de saúde. Desenvolvimento: O objetivo deste trabalho é revisar e comparar os enfoques conceituais pesquisa translacional (translational research), translação do conhecimento (knowledge translation) e mobilização do conhecimento (knowledge mobilization). Estes enfoques se têm desenvolvidos teórica e institucionalmente em países com fortes sistemas de pesquisa em saúde, como os Estados Unidos, a Canadá, e o Reino Unido enquanto na Latino-América têm sido pouco trabalhados. Se identificam seus objetivos, concepção dos processos de transferência de conhecimento, principais aportes e limitações. O enfoque mobilização do conhecimento em saúde destaca-se como uma proposta mais ampla, que aborda o carácter social da produção, transferência e uso do conhecimento. Conclusões: O enfoque de mobilização do conhecimento pode ser um marco útil para o estudo e sistematização de experiências sobre o uso do conhecimento em saúde na região latino-americana, com o objetivo de fortalecer os sistemas nacionais de pesquisa em saúde.


Subject(s)
Humans , Translational Medical Research , Knowledge , Health Services Research
17.
Ciênc. Saúde Colet ; 24(9): 3571-3582, set. 2019.
Article in Portuguese | LILACS | ID: biblio-1019694

ABSTRACT

Resumo Discute-se a reorganização das relações entre a produção científica e as inovações produtivas a partir do quarto final do século XX cuja expressão mais geral foi uma intensa aproximação espaço-temporal entre essas duas atividades. O setor de saúde humana foi um dos setores onde essa aproximação ocorreu com grande intensidade e o texto discute algumas bases conceituais importantes nesse processo, trazendo as contribuições de Gibbons, Stokes e Lundvall-Freeman, bem como as de Merton, Kuhn e Bourdieu no que se refere à organização do trabalho científico. Aponta e discute três processos derivados dessa reorganização, quais sejam a erosão do conceito do conhecimento científico como um bem público, a difusão de um personagem denominado 'pesquisador empreendedor' e o aparecimento da estratégia da pesquisa translacional.


Abstract The scope of this paper is a discussion of the transformative relationship between scientific research and productive innovation, which occurred from the final quarter of the twentieth century onwards. The main characteristic of the phenomenon was an intense space-time approximation of the two activities. The human health sector has been one of the main fields where that approximation was most markedly observed. Some major conceptual bases of the reorganization are discussed, and the text examines works by Gibbons, Stokes and Lundvall-Freeman, as well as Merton, Kuhn and Bourdieu with respect to the organization of the scientific work. The paper highlights and discusses three aspects that arose from the new configuration, namely the erosion of the well-established concept of scientific knowledge as a public good, the appearance of the individual referred to as the 'entrepreneurial researcher' and the emergence of the strategy of translational research in health.


Subject(s)
Humans , Research Personnel/organization & administration , Entrepreneurship , Translational Medical Research/organization & administration , Biomedical Research/organization & administration , Logic
18.
Ciênc. Saúde Colet ; 24(9): 3571-3582, set. 2019.
Article in Portuguese | LILACS | ID: biblio-1019663

ABSTRACT

Resumo Discute-se a reorganização das relações entre a produção científica e as inovações produtivas a partir do quarto final do século XX cuja expressão mais geral foi uma intensa aproximação espaço-temporal entre essas duas atividades. O setor de saúde humana foi um dos setores onde essa aproximação ocorreu com grande intensidade e o texto discute algumas bases conceituais importantes nesse processo, trazendo as contribuições de Gibbons, Stokes e Lundvall-Freeman, bem como as de Merton, Kuhn e Bourdieu no que se refere à organização do trabalho científico. Aponta e discute três processos derivados dessa reorganização, quais sejam a erosão do conceito do conhecimento científico como um bem público, a difusão de um personagem denominado 'pesquisador empreendedor' e o aparecimento da estratégia da pesquisa translacional.


Abstract The scope of this paper is a discussion of the transformative relationship between scientific research and productive innovation, which occurred from the final quarter of the twentieth century onwards. The main characteristic of the phenomenon was an intense space-time approximation of the two activities. The human health sector has been one of the main fields where that approximation was most markedly observed. Some major conceptual bases of the reorganization are discussed, and the text examines works by Gibbons, Stokes and Lundvall-Freeman, as well as Merton, Kuhn and Bourdieu with respect to the organization of the scientific work. The paper highlights and discusses three aspects that arose from the new configuration, namely the erosion of the well-established concept of scientific knowledge as a public good, the appearance of the individual referred to as the 'entrepreneurial researcher' and the emergence of the strategy of translational research in health.


Subject(s)
Humans , Research Personnel/organization & administration , Entrepreneurship , Translational Medical Research/organization & administration , Biomedical Research/organization & administration , Logic
19.
Ciênc. Saúde Colet ; 24(9): 3583-3594, set. 2019.
Article in Portuguese | LILACS | ID: biblio-1019657

ABSTRACT

Resumo O texto apresenta e discute os novos personagens que têm crescente presença no ambiente de pesquisa, quais sejam o pesquisador empreendedor e a universidade empreendedora. Discute ainda o cenário atual da difusão de conhecimento científico que apresenta crescentes problemas, com dificuldade de publicação de resultados e dificuldades de acesso a resultados de pesquisa publicados. Discute também o significado da estratégia da pesquisa translacional e apresenta e discute alguns desafios éticos relevantes que resultam da reorganização das relações entre ciência e negócio. Em particular trata dos conflitos de interesse e dos resultados da supercompetição entre cientistas e instituições em um cenário de encurtamento de apoio financeiro público à ciência.


Abstract The paper introduces and discusses the new players that now have a growing presence on the research scene, namely the entrepreneurial researcher and the entrepreneurial university. It also discusses the current scenario of the diffusion of scientific knowledge that presents increasing problems, with difficulty in publishing results and difficulties in accessing the results of published research. It also discusses the implications of the strategy of translational research and presents and discusses some relevant ethical challenges that result from the reorganization of the relationship between science and business. In particular, it deals with conflicts of interest and the results of excessive competition between scientists and institutions in a scenario of diminished public financial support for science.


Subject(s)
Humans , Research Personnel/organization & administration , Universities/organization & administration , Entrepreneurship/ethics , Translational Medical Research/organization & administration , Publishing , Research Personnel/ethics , Research Support as Topic , Universities/ethics , Conflict of Interest , Ethics, Research , Translational Medical Research/ethics , Logic
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