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1.
Rev. Ciênc. Méd. Biol. (Impr.) ; 21(2): 292-301, out.2022. fig, tab
Article in Portuguese | LILACS | ID: biblio-1400243

ABSTRACT

A dentina e o osso alveolar apresentam muita semelhança em sua composição. Sendo assim, podemos considerar a utilização da dentina como recurso alternativo nas intervenções que buscam a regeneração tecidual óssea. Objetivo: o presente estudo realizou uma revisão integrativa da literatura sobre o uso da dentina como biomaterial para regeneração óssea. Metodologia: foi realizada uma busca por artigos, nas bases de dados Medline, via PubMed; Scielo, LILACS, BASE, Scopus e Science Direct, queavaliassem ou descrevessem o uso da dentina como biomaterial para regeneração óssea. Foram utilizados os seguintes descritores: "Dentin" AND "Bone Regeneration", sem delimitação de tempo. Os critérios de inclusão foram: estudos clínicos publicados em periódicos, oriundos de dados primários, sobre o uso de dentina como biomaterial. Os critérios de exclusão foram: revisões de literatura, estudos in vitro e em animais, estudos que não fosse possível o acesso na íntegra e estudos que associassem o uso da dentina com outros biomateriais sem que fosse possível relacionar os resultados apenas pelo uso da dentina. Resultados: vinte e três estudos foram selecionados para a presente revisão. As pesquisas demonstraram que há uma heterogenicidade relacionada ao tamanho da partícula de dentina obtida, que pode ser decorrente de diferentes métodos de processamento. Conclusão: a reutilização da dentina como biomaterial pode ser uma alternativa promissora ao enxerto autógeno. Sugere-se, então, que protocolos de processamento da partícula de dentina sejam melhor estabelecidos e estudos longitudinais precisam ser realizados para a garantia de procedimentos seguros, eficazes e práticos.


The dentin and the alveolar bone are very similar in composition, therefore, it's usage as an alternative resource in interventions that seek tissue regeneration can be considered. Objective: the aim of the present study was to carry out an integrative review of the literature on the use of dentin as a biomaterial for bone regeneration. Methodology: a search for articles was carried out in the Medline databases, via PubMed; Scielo, LILACS, BASE, Scopus and Science Direct, which evaluated or described the use of dentin as a biomaterial for bone regeneration. The following descriptors were used: "Dentin" AND "Bone Regeneration", without time limits. The inclusion criteria were: clinical studies published in journals, derived from primary data, on the use of dentin as a biomaterial. Exclusion criteria were: literature reviews, in vitro and in animal studies, studies that were not possible to be accessed in full and studies that associated the usage of dentin with other biomaterials and that it was not possible to relate the results just by using the dentin. Results: twenty-three studies were selected for the present review. Researches have shown that there is heterogeneity related to the size of the obtained dentin particle, which may be due to different processing methods. Conclusion: the reuse of dentin as a biomaterial can be a promising alternative to autogenous graft. It is suggested, then, that dentin particle processing protocols should are better established and longitudinal studies need to be carried out to the in order to ensure safe, effective and practical procedures.


Subject(s)
Humans , Animals , Male , Female , Adult , Middle Aged , Transplantation, Autologous , Biocompatible Materials , Bone Regeneration , Dentin
2.
Rev. colomb. cir ; 37(4): 580-587, 20220906. tab, fig
Article in Spanish | LILACS | ID: biblio-1396342

ABSTRACT

Introducción. Los colgajos del territorio de la arteria submentoniana pueden ser utilizados como un colgajo cutáneo, musculofacial y osteocutáneo, realizando cierres primarios del defecto del sitio donante, sin generar defectos funcionales ni estéticos mayores. Métodos. Describir la experiencia de nuestro equipo quirúrgico, las complicaciones relacionadas con el uso del colgajo y los resultados oncológicos, así como los desenlaces tardíos durante el seguimiento de los pacientes incluidos en el estudio. Resultados. Se incluyeron veintiún pacientes, con una edad media de 66 años (rango 52 - 86), con patología oncológica de lengua, labio inferior, paladar blando, nariz, órbita y orofaringe. Todos los pacientes fueron sometidos a disección selectiva ipsilateral del cuello, tras la extracción del colgajo y en todos los casos se preservó el nervio mandibular marginal. Se registraron complicaciones como la necrosis parcial. La estancia hospitalaria media fue de 8 días.Conclusiones. El colgajo de la arteria submentoniana ha mostrado resultados favorables debido a su uso versátil, amplio arco de rotación, color y baja morbilidad del sitio donante. Se recomienda realizar estudios más robustos, que incluyan la experiencia de diversos especialistas en países que compartan las mismas limitaciones técnicas y características sociodemográficas.


Introduction. Flaps from the territory of the submental artery can be used as a cutaneous, musculofacial and osteocutaneous flap, performing primary closure of the donor site defect, without generating major functional or aesthetic defects. Methods. To describe the experience of the same surgical team, the complications related to the use of the flap and the oncological results, as well as the late outcomes during the follow-up of the patients included in the study. Results. Twenty-one patients with a mean age of 66 years (range: 52-86), with oncological pathology of the tongue, lower lip, soft palate, nose, orbit, and oropharynx were included. All patients underwent ipsilateral selective neck dissection after flap removal, and in all cases the marginal mandibular nerve was preserved. Complications such as partial necrosis were recorded. The mean hospital stay was 8 days. Conclusions. The submental artery flap has shown favorable results due to its versatile use, wide arc of rotation, color, and low donor site morbidity. More robust studies are recommended, including the experience of various specialists in countries sharing the same technical limitations and sociodemographic characteristics.


Subject(s)
Humans , Transplantation, Autologous , Myocutaneous Flap , Head and Neck Neoplasms , Postoperative Period , Tissue Transplantation
3.
Rev. cir. traumatol. buco-maxilo-fac ; 22(1): 43-48, jan.-mar. 2022. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1392018

ABSTRACT

O transplante dentário autógeno é um procedimento cirúrgico que consiste na transposição de um elemento dentário do seu alvéolo para um outro, em um mesmo indivíduo. Esta abordagem é indicada para substituir elementos com prognóstico desfavorável ou reabilitar áreas edêntulas. O objetivo deste trabalho é apresentar as vantagens do transplante dentário autógeno frente a perdas dentárias precoces e os critérios necessários para indicação do mesmo, por meio de um relato de caso clínico no qual, uma paciente do gênero feminino, 16 anos foi submetida ao transplante do elemento 48 para o alvéolo do 47 por motivos de lesão cariosa com extensa destruição coronária com impossibilidade de tratamento clínico restaurador. Em acompanhamento pós-operatório de 01 ano os resultados demostraram continuidade do desenvolvimento radicular do elemento transplantado em seu novo alvéolo, estando este, sem mobilidade, livre de lesões periodontais e/ou endodônticas. Desta forma, conclui-se que as vantagens do transplante dentário autógeno incluem a possibilidade de reabilitação dentária de forma natural, imediata e de baixo custo comparado a tratamentos como implantes e próteses. E este método quando indicado corretamente e realizado sob os devidos cuidados pode alcançar excelentes resultados funcionais e estéticos, sendo uma opção viável para reabilitação de perdas dentárias precoces... (AU)


The Autogenous dental transplantation is a surgical procedure that consists of the transposition of a dental element from its socket to another, in the same individual. This approach is indicated to replace elements with an unfavorable prognosis or to rehabilitate edentulous areas. The objective of this paper is to present the advantages of autogenous dental transplantation against early tooth loss and the necessary criteria for its indication, through a clinical case report in which a 16-year-old female patient underwent transplantation element 48 for the alveolus of the 47 due to carious lesions with extensive coronary destruction with impossibility of restorative clinical treatment. In a 01-year postoperative follow-up, the results showed continuity of root development of the transplanted element in its new alveolus, which is without mobility, free from periodontal and/or endodontic lesions. Thus, it is concluded that the advantages of autogenous dental transplantation include the possibility of natural, immediate and low-cost dental rehabilitation compared to treatments such as implants and prostheses. And this method, when correctly indicated and performed with due care, can achieve excellent functional and esthetic results, being a viable option for the rehabilitation of early tooth loss... (AU)


El trasplante dentario autógeno es un procedimiento quirúrgico que consiste en la transposición de un elemento dentario de su alvéolo a otro, en el mismo individuo. Este abordaje está indicado para reemplazar elementos con pronóstico desfavorable o para rehabilitar áreas edéntulas. El objetivo de este trabajo es presentar las ventajas del trasplante dentario autógeno frente a la pérdida dentaria precoz y los criterios necesarios para su indicación, mediante el reporte de un caso clínico en el que se trasplantó a una paciente de sexo femenino de 16 años. 47 por lesiones cariosas con extensa destrucción coronaria con imposibilidad de tratamiento clínico restaurador. En un seguimiento postoperatorio de 01 año, los resultados mostraron continuidad del desarrollo radicular del elemento trasplantado en su nuevo alvéolo, que se encuentra sin movilidad, libre de lesiones periodontales y/o endodónticas. Así, se concluye que las ventajas del trasplante dental autógeno incluyen la posibilidad de una rehabilitación dental natural, inmediata y de bajo costo frente a tratamientos como implantes y prótesis. Y este método, correctamente indicado y realizado con el debido cuidado, puede lograr excelentes resultados funcionales y estéticos, siendo una opción viable para la rehabilitación de la pérdida dentaria temprana... (AU)


Subject(s)
Humans , Female , Adolescent , Surgical Procedures, Operative , Surgery, Oral , Transplantation, Autologous , Tooth Loss , Molar/surgery , Molar/transplantation
4.
Rev. argent. cir. plást ; 28(1): 8-12, 20220000. fig
Article in Spanish | LILACS, BINACIS | ID: biblio-1392203

ABSTRACT

Durante los últimos años, la cirugía endoscópica transesfenoidal se ha convertido en el procedimiento quirúrgico de elección para el tratamiento de tumores hipofisarios. La técnica de abordaje actual es el resultado de una evolución histórica de vía por craneotomía a vía endonasal con ingreso a través del seno esfenoidal. Aunque la cirugía de tumores hipofisarios vía transesfenoidal endoscópica ha permitido disminuir las complicaciones graves asociadas a los abordajes externos, no está exenta de complicaciones, como la fístula de líquido cefalorraquídeo. A nivel del abordaje nasal, hay escasas descripciones de complicaciones y el compromiso del cartílago septal con deformidad en silla de montar no es una complicación documentada. Se presenta un caso de rinodeformidad en silla de montar poscirugía transesfenoidal de hipófisis en una paciente de 32 años a quien se le practicó una reconstrucción nasal con cartílago costal autólogo. En nuestra búsqueda bibliográfica es el primer caso registrado en Iberolatinoamérica


In recent years, transsphenoidal endoscopic surgery has become the surgical procedure of choice for the treatment of pituitary tumors. The current approach technique is the result of an historical evolution from craniotomy surgery to an endonasal procedure with entry through the sphenoid sinus. Although endoscopic transsphenoidal surgery has made it possible to reduce serious complications associated with external approaches, it is not without complications, such as cerebrospinal fluid fistula. At the level of the nasal approach, there are few descriptions of complications and involvement of the septal cartilage with saddle deformity is not a documented complication. We present a case of saddle rhinodeformity after transsphenoidal pituitary surgery in a 32-year-old patient who underwent nasal reconstruction with autologous costal cartilage. In our bibliographic search, it is the first case registered in IberoLatin America.


Subject(s)
Humans , Female , Adult , Pituitary Diseases/complications , Postoperative Complications/therapy , Transplantation, Autologous , Nose/surgery , Nose Neoplasms/therapy , Natural Orifice Endoscopic Surgery/methods , Costal Cartilage/transplantation
5.
Chinese Journal of Stomatology ; (12): 495-502, 2022.
Article in Chinese | WPRIM | ID: wpr-935892

ABSTRACT

Objective: To screen and analyze the factors affecting the prognosis of replacing single missing tooth by autograft tooth, so as to provide reference for clinical judgment of surgical prognosis. Methods: A total of 176 patients (188 teeth) underwent autotransplantation of teeth in the Department of Oral & Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University from January 2017 to December 2019, including 85 teeth of males and 103 teeth of females were involved. The age was (33.0±9.8) years (16-65 years). The possible factors affecting the prognosis of replacing single missing tooth by autograft tooth were summarized and grouped, and the clinical and imaging data were recorded and judged. The surgical records and photographic data from the patients' previous medical records were retrospectively analyzed. The survival analysis method was used for statistical analysis to screen out the factors affecting the cumulative survival rate of transplanted teeth. Results: The 5-year cumulative survival rate of 188 transplanted teeth was 88.4%. Univariate Log-Rank analysis showed that age (P<0.001), sex (P=0.008), smoking (P<0.001), position of recipient area (P<0.001), height of alveolar bone in recipient area (P<0.001), time of donor tooth in vitro (P<0.001), use of donor model (P<0.001) and initial stability (P<0.001) were significantly correlated with cumulative survival rate of transplanted teeth. Multivariate Cox proportional hazard regression analysis showed that smoking (β=-2.812, P=0.049), alveolar bone height (β=1.521, P=0.020), donor time (β=-2.001, P=0.019), use of donor model (β=1.666, P=0.034) and initial stability (β=-1.417, P=0.033) were significantly correlated with the cumulative survival rate of transplanted teeth. Conclusions: The prognosis of autogenous tooth transplantation can be predicted by smoking, height of alveolar bone in recipient area, time of donor teeth in vitro, use of donor model and initial stability. Good prognosis of transplanted teeth can be obtained by using donor model during operation, reducing the time of donor teeth in vitro, taking effective methods to restore alveolar bone height, maintaining good initial stability, and good oral health education after operation.


Subject(s)
Adult , Female , Humans , Male , Prognosis , Retrospective Studies , Tooth/transplantation , Tooth Loss , Transplantation, Autologous , Treatment Outcome , Young Adult
6.
Chinese Journal of Surgery ; (12): 27-31, 2022.
Article in Chinese | WPRIM | ID: wpr-935575

ABSTRACT

When abdominal neoplasms originating from the pancreas or nearby organs locally involving the superior mesenteric artery (SMA), complete resection is still the only hope for cure. However, SMA resection and reconstruction is a complex surgical procedure associated with high postoperative morbidity and mortality. Intestinal autotransplantation has recently emerged in clinical practice as a treatment option for selected patients with neoplasms involving the SMA. The original procedure involved en bloc removal of a tumor together with the intestine, ex vivo resection and reconstruction of gastrointestinal tract by an intestinal autograft. To further refine this complex procedure, a modified method was developed in which a segmental bowel autograft is selected and harvested first during the initial stage of the operation, and radical resection of the neoplasm is carried out thereafter. The modification would better protect a healthy bowel autograft from potential damage due to prolonged warm ischemia and allow the subsequent lengthy process of dissection to be performed in an unrushed manner. Furthermore, this alteration would better adhere to the general principles of minimal tumor manipulation during operation and potentially decrease the risks of tumor implantation during in vitro organ perfusion. Although intestinal autotransplantation has expanded eligibility for resection of otherwise unresectable lesions involving the SMA, its operative complexity, high risks, and post-operative complications largely limit its clinical applications.


Subject(s)
Humans , Intestines , Mesenteric Artery, Superior/surgery , Pancreatic Neoplasms , Transplantation, Autologous
7.
Chinese Journal of Hematology ; (12): 408-413, 2022.
Article in Chinese | WPRIM | ID: wpr-929628

ABSTRACT

Objective: To investigate the influence of the number of high-risk cytogenetic abnormalities (HRCA) on the clinical characteristics and prognosis of patients with newly diagnosed multiple myeloma (MM) . Methods: A total of 360 patients with newly diagnosed MM admitted to Jiangsu Province Hospital between November 2013 and September 2020 were included in this study. Cytoplasmic light chain immunofluorescence with fluorescence in situ hybridization (cIg-FISH) was used to detect HRCA. Cytogenetic abnormalities were combined with clinical characteristics and outcomes for further analysis. Results: Among the 360 patients, 120 patients (33.3%) presented with no HRCAs, and 175 (48.6%) , 61 (16.9%) , and four (1.1%) patients had one, two, and three HRCA (s) , respectively. Patients were divided into three groups, including the no-HRCA group, one-HRCA group, and ≥two-HRCA group, according to the number of HRCAs. There were significant differences in the R-ISS stage, hemoglobin level, albumin level, and the proportion of bone marrow plasma cells among the three groups (P<0.05) . The COX proportional-hazards model identified extramedullary disease (P=0.018) , HRCA ≥ 2 (P=0.001) , and absence of autologous hematopoietic stem cell transplantation (P<0.001) as independent risk factors for progression free survival (PFS) and identified lactate dehydrogenase (LDH) level ≥ 220 U/L (P<0.001) , HRCA ≥2 (P=0.001) , and absence of autologous hematopoietic stem cell transplantation (P=0.005) as independent risk factors for overall survival (OS) . The median PFS was 28 months, 22 months, and 14 months (P=0.005) for the three cohorts, and their OS was not reached,60 months, and 30 months (P=0.001) , respectively. Conclusions: HRCA ≥ 2 is an independent risk factor for decreased survival in patients with newly diagnosed MM. More HRCAs result in heavier tumor burden, as well as a higher risk of disease progression and death.


Subject(s)
Chromosome Aberrations , Hematopoietic Stem Cell Transplantation , Humans , In Situ Hybridization, Fluorescence , Multiple Myeloma/genetics , Prognosis , Retrospective Studies , Transplantation, Autologous
8.
Chinese Journal of Hematology ; (12): 215-220, 2022.
Article in Chinese | WPRIM | ID: wpr-929560

ABSTRACT

Objective: This study aimed to determine the efficacy of dose-enhanced immunochemotherapy followed by autologous peripheral blood stem cell transplantation (ASCT) in young patients with newly diagnosed high-risk aggressive B-cell lymphoma. Methods: A retrospective study was conducted to examine the clinical and survival data of young patients with high-risk aggressive B-cell lymphoma who received dose-enhanced immunochemotherapy and ASCT as first-line treatment between January 2011 and December 2018 in Blood Diseases Hospital. Results: A total of 63 patients were included in the study. The median age range was 40 (14-63) years old. In terms of the induction therapy regimen, 52 cases received R-DA-EP (D) OCH, and the remaining 11 received R-HyperCVAD/R-MA. Sixteen (25.4% ) patients achieved partial response in the mid-term efficacy assessment, and ten of them were evaluated as complete response after transplantation. The median follow-up was 50 (8-112) months, and the 3-year progression-free survival (PFS) rate and overall survival (OS) rate were (83.9±4.7) % and (90.4±3.7) % , respectively. Univariate analysis demonstrated that age-adjusted international prognostic index ≥2 scores was a negative prognostic factor for OS (P=0.039) , and bone marrow involvement (BMI) was an adverse prognostic factor for OS (P<0.001) and PFS (P=0.001) . However, multivariate analysis confirmed that BMI was the only independent negative predictor of OS (P=0.016) and PFS (P=0.001) . Conclusions: The use of dose-enhanced immunochemotherapy in combination with ASCT as first-line therapy in the treatment of young, high-risk aggressive B-cell lymphoma results in good long-term outcomes, and BMI remains an adverse prognostic factor.


Subject(s)
Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Disease-Free Survival , Hematopoietic Stem Cell Transplantation , Humans , Lymphoma, B-Cell , Peripheral Blood Stem Cell Transplantation , Prognosis , Retrospective Studies , Stem Cell Transplantation , Transplantation, Autologous
9.
Chinese Journal of Hematology ; (12): 141-145, 2022.
Article in Chinese | WPRIM | ID: wpr-929546

ABSTRACT

Objective: To evaluate the efficacy and safety of autologous hematopoietic stem cell transplantation (auto-HSCT) in elderly patients (≥65 years old) with multiple myeloma (MM) . Methods: From June 1, 2006 to July 31, 2020, 22 MM patients (≥65 years old) who were diagnosed in the First Affiliated Hospital, Sun Yat-sen University and received novel drug induction followed by auto-HSCT were analyzed retrospectively. These patients were evaluated for important organ functions before transplantation, and the International Myeloma Working Group frail score was used in 2016 to screen out transplant-eligible patients. Results: The median (interquartile range, IQR) age at the time of transplantation of the 22 patients was 66.75 (IQR 4.50) years. A total of 20 patients received stem cell mobilization. The median number of mononuclear cells collected was 4.53×10(8)/kg, that of CD34(+) cells was 3.37×10(6)/kg, and the median number of apheresis procedures performed was 2. After stem cell transfusion, the median time of neutrophil implantation was 11 days, that of platelet implantation was 13 days, and the treatment-related mortality was 0 at 100 days after transplantation. The median follow-up was 48.7 months. The median time to progression time was not reached, and the median overall survival time was 111.8 months. Conclusion: Auto-HSCT is a safe and effective treatment for selected elderly patients of 65 years or older with MM.


Subject(s)
Aged , Hematopoietic Stem Cell Mobilization/methods , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Multiple Myeloma/drug therapy , Retrospective Studies , Transplantation, Autologous/methods , Treatment Outcome
10.
Article in English | WPRIM | ID: wpr-939778

ABSTRACT

OBJECTIVE@#To compare the analgesic effects of two types of spinal manipulation (SM) in acute lumbar radiculopathy (ALR) model rats induced by self-transplantation of autologous nucleus pulposus (ANP), and clarify the therapeutic mechanism.@*METHODS@#Totally 108 male Sprague-Dawley rats were randomly divided into 6 groups by a random number table (18 rats in each group), including a blank group with no interference, a sham operation group with a surgery by making a local soft tissue incision on the left side of L5-6 vertebral segment, a model group with ALR of L5 extraforaminal nerve by ANP self-transplantation without other interference, a sham manipulation (SMA) group with simulating physical rotation, as well as a mobilization (MOB) group with simulating low-velocity and variable-amplitude rotation and a manipulation (MAN) group with simulating high-velocity and low-amplitude rotation. The interventions in SMA, MOB, and MAN groups started 1 day after modeling followed by another 5 treatments at days 3, 5, 8, 10 and 12. Rats in the other 3 groups did not receive any special intervention. Behavioral pain tests of 50% mechanical pain withdrawal threshold (50% PWT) and paw withdrawal latency (PWL) were conducted 1 day before operation followed by another 10 tests on days 1-7, 10, 12 and 14. Immunohistochemical expression of nitric oxide synthase (NOS) was investigated on days 5 and 12 after operation.@*RESULTS@#After 3 experimental SM interventions, 50% PWT and PWL were higher in the MAN group than the SMA group on days 6 and 7, and higher on days 10, 12 and 14 postoperatively (P<0.05 or P<0.01), while the same indices were significantly higher in the MOB group than MAN group on days 1-4 (P<0.05 or P<0.01). The expression of NOS was lower in the MAN and MOB groups than SMA group on day 12 postoperatively (P<0.01).@*CONCLUSIONS@#Both manipulation and mobilization produced better results than sham interference in relieving pain by reducing neuroinflammation possibly. At the early period, compared with manipulation, mobilization presented less sensitive response to pain until later visit. SM may inhibit the overexpression of NOS, thereby alleviating severe radiculopathy.


Subject(s)
Analgesia/methods , Animals , Male , Manipulation, Spinal , Nucleus Pulposus/transplantation , Pain , Radiculopathy/therapy , Rats , Rats, Sprague-Dawley , Transplantation, Autologous
11.
Article in Chinese | WPRIM | ID: wpr-939713

ABSTRACT

OBJECTIVE@#To investigate the safety and efficacy of a new proteasome inhibitor Ixazomib followed by autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of POEMS syndrome.@*METHODS@#The clinical manifestations, diagnosis and treatment process and follow-up results of 4 patients with POEMS syndrome who were treated with Ixazomib-based regimen combined with AHSCT in Wuhan No.1 Hospital from February 2018 to July 2020 were analyzed retrospectively. All patients were male, aged from 37-54 years old, with varying degrees of peripheral neuropathy, organ enlargement (liver, spleen or lymph nodes), circulatory overload (peripheral edema and/or pleural effusion), osteosclerosis, endocrine diseases (thyroid, gonads, etc.), skin changes (pigmentation, hemangioma, white nails, etc.), M protein, papilledema and other clinical manifestations and characteristics at the time of initial treatment. Two patients were pathologically diagnosed as hyaline vascular Castleman disease by lymph node biopsy. Three patients underwent lumbar puncture examinations and all showed elevated cerebrospinal fluid protein. All patients received at least 2 cycles of sequential AHSCT after induction chemotherapy based on ixazomib. The follow-up time was 10-28 months, and the median follow-up time was 16 months.@*RESULTS@#All cases survived. The complications were controllable during the treatment. Moreover, the clinical symptoms related to the disease were improved to a certain extent after the treatment. The levels of vascular endothelial growth factor (VEGF) showed a gradual decline.@*CONCLUSION@#Ixazomib combined with AHSCT is safe and effective in the treatment of POEMS syndrome.


Subject(s)
Adult , Boron Compounds , Glycine/analogs & derivatives , Hematopoietic Stem Cell Transplantation , Humans , Male , Middle Aged , POEMS Syndrome/therapy , Retrospective Studies , Transplantation, Autologous , Vascular Endothelial Growth Factor A
12.
Article in Chinese | WPRIM | ID: wpr-928686

ABSTRACT

OBJECTIVE@#To compare the clinical efficacy, survival, and prognosis of autologous hematopoietic stem cell transplantation (ASCT) with new drug chemotherapy in the treatment of newly diagnosed multiple myeloma (NDMM) in the new drug era.@*METHODS@#The clinical data of 149 patients with NDMM treated with new drug induction regimen in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2012 to December 2019 were retrospectively analyzed. Twenty-four patients who received ASCT were in ASCT group, and 125 patients who did not receive ASCT were in non-ASCT group. The median follow-up time was 43 (1-90) months. The propensity score matching (PSM) method was used to balance confounding factors, then depth of response, overall survival (OS), and progression-free survival (PFS) between the two groups were compared and subgroup analysis was performed.@*RESULTS@#After matching, the covariates were balanced between the two groups. Fifty-one patients (15 cases in ASCT group and 36 cases in non-ASCT group) were included. ASCT patients had a better complete response (CR) rate than non-ASCT patients receiving maintenance therapy (93.3% vs 42.3%, P=0.004), while there were no statistical differences in deep response rate and overall response rate (ORR) between the two groups (93.3% vs 65.4%, P=0.103; 93.3% vs 96.2%, P=1.000). Before matching, the 3 and 5-year PFS rate and median PFS (mPFS) in ASCT group and non-ASCT group were [89.6% vs 66.5%, P=0.024; 69.8% vs 42.7%; non-response (NR) vs 51.0 months], and the 3 and 5-year OS rate and median OS (mOS) were (100% vs 70.6%, P=0.002; 92.3% vs 49.6%; NR vs 54.0 months). After matching, the 3 and 5-year PFS rate and mPFS in ASCT group and non-ASCT group were (83.6% vs 61.7%, P=0.182; 62.7% vs 45.7%; NR vs 51.0 months), the 3 and 5-year OS rate and mOS were (100% vs 65.6%, P=0.018; 88.9% vs 46.9%; NR vs 51.0 months). Subgroup analysis showed that patients with mSMART 3.0 high risk stratification, the 3-year PFS rate and mPFS in ASCT group and non-ASCT group were (83.3% vs 41.5%, P=0.091; NR vs 34.0 months), and the 3-year OS rate and mOS were (100% vs 41.5%, P=0.034; NR vs 34.0 months). Patients with mSMART 3.0 standard risk stratification, the 3-year PFS rate and OS rate in ASCT group and non-ASCT group were (83.3% vs 76.8%, P=0.672; 100% vs 87.2%, P=0.155). The 3-year PFS and OS rate in MM patients who achieved deep response within 3 months after transplantation compared with non-ASCT patients who achieved deep response after receiving maintenance therapy were (83.1% vs 56.7%, P=0.323; 100% vs 60.5%, P=0.042), and the 3-year PFS and OS rate in patients who achieved overall response in both groups were (83.1% vs 62.5%, P=0.433; 100% vs 68.1%, P=0.082). After matching, Cox multivariate regression analysis showed that mSMART 3.0 risk stratification and ASCT were independent prognostic factors for OS.@*CONCLUSION@#In the new drug era, ASCT can increase CR rate and prolong OS of NDMM patients. ASCT patients who are mSMART 3.0 high risk stratification or achieved deep response within 3 months after transplantation have better OS than non-ASCT patients receiving new drug chemotherapy. ASCT and mSMART 3.0 risk stratification are independent prognostic factors for OS in NDMM patients.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols , Disease-Free Survival , Hematopoietic Stem Cell Transplantation , Humans , Multiple Myeloma/drug therapy , Pharmaceutical Preparations , Propensity Score , Retrospective Studies , Stem Cell Transplantation , Transplantation, Autologous , Treatment Outcome
13.
Article in Chinese | WPRIM | ID: wpr-928680

ABSTRACT

OBJECTIVE@#To analyze the clinical characteristics and long-term prognosis of patients with primary bone lymphoma (PBL).@*METHODS@#The clinical data of 21 patients with PBL treated in our center from 2005 to 2018 were analyzed retrospectively, the clinical characteristics and the factors affecting prognosis of the patients were analyzed.@*RESULTS@#The median age of all the 21 newly diagnosed PBL patients was 40(12-71) years old. Ostealgia was the initial symptom in most of the patients (19/21,90.5%). 42.9%(9/21) of the patients showed single bone lesion only. 571% (12/21) of the patients showed diffuse large B cell lymphoma. 28.6% (6/21) of the patients showed anaplastic large cell lymphoma and 9.5% (2/21) of the patients showed T cell lymphoblastic lymphoma. All the patients received chemotherapy (CHOP or CHOP like regimen, 33.3% plus rituximab) with or without radiotherapy and/or autologous hematopoietic stem cell transplantation (ASCT). 18 patients achieved clinical remission (including 15 for CR and 3 for PR). The median follow-up time was 48 months. The 5-year overall survival rate and progression-free survival rate of the patients were was 67.5% and 63.7%, respectively. The single factors analysis showed that ASCT was the important prognostic factor of PFS, while the single or multiple bone lesion was the factors affecting OS of the patients. There were no statistical differences with the effects of age, sex, stage, ECOG score, LDH level, B symptoms and radiotherapy for the prognosis of patients.@*CONCLUSION@#Diffuse large B cell lymphoma is the most common pathological type of PBL. Chemotherapy is the main treatment, which can be combined with radiotherapy and/or ASCT. The ASCT and the number of bone lesion are the factors for long time survival of the patients.


Subject(s)
Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide , Disease-Free Survival , Doxorubicin , Humans , Lymphoma, Large B-Cell, Diffuse/drug therapy , Middle Aged , Prednisone , Prognosis , Retrospective Studies , Rituximab/therapeutic use , Transplantation, Autologous , Vincristine
14.
Artrosc. (B. Aires) ; 29(3): 129-135, 2022.
Article in Spanish | LILACS, BINACIS | ID: biblio-1396320

ABSTRACT

Existen múltiples opciones de tratamientos para las rupturas masivas irreparables posterosuperiores del manguito rotador. Describiremos la transferencia del trapecio inferior con aumentación utilizando semitendinoso y recto interno autólogos, bajo asistencia. De esta manera devolvemos el balance muscular y restablecemos las cuplas de fuerza para la correcta movilidad del hombro afectado. Esta técnica se realiza con dos incisiones y tres portales artroscópicos: la primera para la toma del recto interno y semitendinoso en la rodilla del mismo lado del hombro afectado (aumentación), y la segunda en la escápula para la toma del trapecio inferior y para el pasaje de los tendones al espacio subacromial y posterior fijación con anclas sin nudo


In massive irreparable posterosuperior rotator cuff ruptures, there are several options for treatment. We will describe the transfer of the lower trapezius muscle tendon augmented with semitendinosus and gracillis tendons autologous, under arthroscopic assistance. In this way, muscular balance is restored for correct shoulder mobility. This technique is performed with two incisions and three arthroscopic portals, the first for harvest of the gracillis and semitendinosus tendons, in the knee on the same side of the affected shoulder (augmentation) and the second in the scapula for the harvest of the lower trapezius muscle tendon, and for passage to the subacromial, and fixation with knotless anchors


Subject(s)
Tendon Transfer , Transplantation, Autologous , Rotator Cuff Injuries
15.
Rev. bras. oftalmol ; 81: e0019, 2022. graf
Article in English | LILACS | ID: biblio-1365723

ABSTRACT

ABSTRACT Objective: To describe results of pterygium surgery at Clínica de Cirurgía Ocular Villavicencio, in Meta, Colombia. Methods: A retrospective analysis of pterygium surgeries performed between January 2017 and December 2019. Results: Approximately 1,200 records were reviewed, and 1,200 procedures included. The most frequent complications were corneal Dellen, pterygium recurrence, graft retraction and pyogenic granuloma (7.5%, 2.5%, 3% and 0.75% respectively). These were identified within the first 6 months of surgery. Conclusion: Pterygium surgery using conjunctival autografts is an effective technique, with low recurrence rates and very few complications.


RESUMO Objetivo: Descrever os resultados da cirurgia de pterígio na Clínica de Cirurgía Ocular Villavicencio, Meta, Colômbia. Métodos: Análise retrospectiva de cirurgias de pterígio realizadas entre janeiro de 2017 e dezembro de 2019. Resultados: Aproximadamente 1.200 prontuários foram revisados e 1.200 procedimentos foram incluídos. As complicações mais frequentes foram o Dellen corneano, a recorrência do pterígio, a retração do enxerto e o piogranuloma (7,5%, 2,5%, 3% e 0,75%, respectivamente). Essas complicações foram identificadas nos primeiros 6 meses após a cirurgia. Conclusão: A cirurgia de pterígio pela técnica de autoenxerto conjuntival é um procedimento eficaz, com baixos índices de recorrência e poucas complicações.


Subject(s)
Humans , Male , Female , Transplantation, Autologous , Pterygium/surgery , Conjunctiva/transplantation , Retrospective Studies , Limbus Corneae , Colombia , Observational Study
16.
Rev. bras. oftalmol ; 81: e0059, 2022. graf
Article in Portuguese | LILACS | ID: biblio-1407674

ABSTRACT

RESUMO O pterígio é uma das doenças que mais acomete a superfície ocular, principalmente em regiões próximas ao Equador. Ocorre principalmente em adultos jovens, podendo ocasionar sintomas, danos estéticos e ópticos. Relata-se um caso de exérese de pterígio classificado pela extensão corneana em grau II e, pela vascularização, em grau 2 de Tan, com cirurgia prévia de LASIK, a partir de uma nova técnica, a técnica de Moscovici, a qual fundamenta-se na dissecção com bolha de ar, com a finalidade de separar o epitélio conjuntival do estroma profundo e da Tenon, com maior facilidade e rapidez e para obter enxertos finos.


ABSTRACT Pterygium is one of the diseases that most affect the ocular surface, especially in regions close to the equator. It mainly affects young adults and can cause symptoms, as well as aesthetic and optical impairment. We report a case of pterygium excision classified by grade II corneal extension and Tan grade 2 vascularization with previous laser in situ keratomileusis (LASIK) surgery, using a new technique, the Moscovici technique, which is based on dissection with an air bubble to separate easier and faster the conjunctival epithelium from the deep stroma and the Tenon, obtaining thinner grafts.


Subject(s)
Humans , Male , Middle Aged , Tissue Adhesives , Pterygium/surgery , Ophthalmologic Surgical Procedures/methods , Transplantation, Autologous , Pterygium/classification , Pterygium/etiology , Visual Acuity , Fibrin Tissue Adhesive/therapeutic use , Conjunctiva/transplantation , Keratomileusis, Laser In Situ/adverse effects , Tomography, Optical Coherence , Air , Injections
17.
Rev. Fac. Odontol. (B.Aires) ; 37(85): 31-37, 2022. ilus
Article in Spanish | LILACS | ID: biblio-1398317

ABSTRACT

El trasplante dentario autólogo se define como el po-sicionamiento de una pieza dentaria autóloga en un alvéolo post extracción o en un lecho formado qui-rúrgicamente. Actualmente, siguiendo los criterios de selección adecuados y una técnica quirúrgica mi-nuciosa, resulta una alternativa terapéutica ideal en ciertos pacientes. La gran variabilidad de implantes dentales y alternativas de injertos óseos han resuelto el problema de sustituir una pieza dentaria perdida. En los pacientes en crecimiento o con potencial de crecimiento residual del proceso alveolar, se pone en evidencia el inconveniente que puede representar la colocación de implantes, lo que hace necesario ree-valuar la conservación de dientes y la utilización de técnicas quirúrgicas clásicas. Las tasas de éxito de los autotrasplantes autólogos han aumentado con el tiempo, alcanzando cifras mayores al 90%. En el pre-sente artículo se reporta un caso clínico de autotras-plante dentario con planificación digital y una réplica tridimensional de la pieza a trasplantar (AU)


Autologous tooth transplantation is defined as the positioning of an autologous tooth in a post-extraction socket or in a surgically formed bed. Currently, following the appropriate selection criteria and a meticulous surgical technique, it is an ideal therapeutic alternative in certain patients. The great variability of dental implants and bone graft alternatives have solved the problem of replacing a lost tooth. In growing patients or with potential for residual growth of the alveolar process, the inconvenience that implant placement can represent is evident, which makes it necessary to reevaluate tooth conservation and the use of classic surgical techniques. The success rates of autologous autologous transplants have increased over time, reaching figures greater than 90%. This article reports a clinical case of dental autotransplantation with digital planning and a three-dimensional replica of the piece to be transplanted (AU)


Subject(s)
Humans , Female , Adolescent , Transplantation, Autologous , Imaging, Three-Dimensional , Molar, Third/transplantation , Osteotomy/methods , Patient Care Planning , Argentina , Schools, Dental , Tooth Socket , Surgery, Computer-Assisted , Printing, Three-Dimensional
18.
Int. j. morphol ; 40(5): 1186-1193, 2022. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1405298

ABSTRACT

RESUMEN: El objetivo del estudio fue comparar el déficit propioceptivo a través del Joint position sense (JPS) y Force steadiness en pacientes con reconstrucción del ligamento cruzado anterior (LCA) injerto hueso-tendón patelar-hueso (HTH) 6 a 12 meses postcirugía. Participaron 15 pacientes (13 hombres y 2 mujeres, 25,5 ± 1,3 años) con reconstrucción de LCA con autoinjerto HTH y 20 personas sin lesión del LCA (19 hombres y 1 mujer, 24,1 ± 0,8 años). Para evaluar la sensación de posición de la articulación de la rodilla se midió la Joint position sense (JPS) en tres rangos: 0°-30°, 31°-60° y 61°-90° y la sensación de fuerza del cuádriceps fue evaluada con la prueba Force steadiness (FS) al 15 % de la contracción voluntaria máxima (CVM), ambas pruebas realizadas 6 a 12 meses post cirugía. Los resultados mostraron que no hubo diferencias estadísticamente significativas en la sensación de la posición articular (JPS 0°-30°) (p=0.564) y 31°-60° (p=0.681), mientras que en el rango 61°-90° (p=0.003) existieron diferencias estadísticamente significativas. En las mediciones de sensación de fuerza del cuádriceps (FS al 15 % CVM) entre los pacientes operados de LCA técnica HTH y el grupo control no hubo diferencias estadísticas (p= 0.987) La sensación de la fuerza del cuádriceps medida con la prueba FS al 15 % CVM no presentaría déficit entre los 6 a 12 meses en pacientes post operados de LCA al ser comparados con sujetos sin lesión ni cirugía de este ligamento. Se concluye que la sensación de la posición articular medida con la prueba JPS en en tres rangos articulares de pacientes con reconstrucción de LCA injerto HTH 6 a 12 meses post cirugía sólo mostró alteraciones en el rango de 61°- 90° al ser comparado con el grupo control, lo cual indica que la sensación de la posición articular presenta un déficit en este rango específico.


SUMMARY: The aim of the study was to compare the proprioceptive deficit through the Joint position sense (JPS) and Force steadiness in patients with anterior cruciate ligament (ACL) bone-patellar tendon-bone graft (PTH) reconstruction 6 to 12 months post-surgery. Fifteen patients (13 men and 2 women, 25.5 ± 1.3 years) with ACL reconstruction with HTH autograft and 20 persons without ACL injury (19 men and 1 woman, 24.1 ± 0.8 years) participated. To assess knee joint position sensation, Joint position sense (JPS) was measured in three ranges: 0°-30°, 31°- 60° and 61°-90° and quadriceps strength sensation was assessed with the Force steadiness (FS) test at 15 % of maximal voluntary contraction (MVC), both tests performed 6 to 12 months post surgery. The results showed that there were no statistically significant differences in joint position sensation (JPS 0°-30°) (p=0.564) and 31°-60° (p=0.681), while in the range 61°-90° (p=0.003) there were statistically significant differences. In the quadriceps strength sensation measurements (FS at 15 % CVM) between the patients operated on ACL HTH technique and the control group there were no statistical differences (p= 0.987). The quadriceps strength sensation measured with the FS test at 15 % CVM would not present a deficit between 6 to 12 months in post- operated ACL patients when compared to subjects without injury or surgery of this ligament. It is concluded that the joint position sensation measured with the JPS test in three joint ranges of patients with ACL reconstruction HTH graft 6 to 12 months post surgery only showed alterations in the range of 61°- 90° when compared to the control group, indicating that the joint position sensation presents a deficit in this specific range.


Subject(s)
Humans , Male , Female , Patellar Ligament/physiology , Bone-Patellar Tendon-Bone Grafting , Anterior Cruciate Ligament Reconstruction , Knee Joint/physiology , Postoperative Period , Proprioception/physiology , Transplantation, Autologous , Range of Motion, Articular , Muscle Strength/physiology
19.
Rev. cir. traumatol. buco-maxilo-fac ; 21(4): 14-19, out.-dez. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1391245

ABSTRACT

A importância da permanência dos dentes naturais na cavidade bucal vem sendo cada dia mais reconhecida e almejada, seja pelo fator estético ou pelo funcional. Uma alternativa para a reabilitação de indivíduos com perdas dentárias ou exodontias indicadas é o transplante dental. Esta modalidade de tratamento corresponde à transferência de um órgão dental, para um alvéolo receptor. O presente trabalho relata e discute um caso de triplo transplante autógeno, utilizando terceiros molares, enfatizando as etapas cirúrgicas e demonstrando que após dois anos de preservação os resultados confirmam o sucesso deste tratamento. Anamnese, exames clínicos e radiográficos foram analisados de forma criteriosa, antes e após a cirurgia, sendo a radiografia panorâmica utilizada antes e após o ato cirúrgico e radiografias periapicais após, para acompanhamento individual das unidades transplantadas. Houve sucesso na realização dos transplantes dentários, obtendo regeneração pulpar e adaptação ao alvéolo receptor, mantendo o espaço dental com vitalidade e oclusão dentaria satisfatória. O procedimento apresentou sucesso significativo, obtendo êxito nas três unidades transplantadas, devolvendo o equilíbrio ao desenvolvimento crânio facial, comprovando sua eficácia na reabilitação oral em jovens com perdas prematuras de unidades dentárias... (AU)


The importance of the maintenance of natural teeth in the oral cavity has been increasingly recognized and desired, for the aesthetic and also the functional factor. An alternative for the rehabilitation of individuals with indicated tooth loss or extractions is dental transplantation. This type of treatment corresponds to the transfer of a dental organ to a recipient alveolar socket. The present work reports and discusses a case of triple autogenous transplantation, using third molars, emphasizing the surgical stages and demonstrating that after two years of preservation the results confirm the success of this treatment. Anamnesis, clinical and radiographic examinations were carefully analyzed, before and after surgery, with panoramic radiography used before and after surgery and periapical radiographs afterwards, for individual monitoring of transplanted units. Dental transplants were successful in achieving pulp regeneration and adaptation to the recipient alveolus, maintaining the dental space with vitality and satisfactory dental occlusion. The procedure was significantly successful, achieving success in the three transplanted units, restoring balance to the facial skull development, proving its effectiveness in oral rehabilitation in young people with premature loss of dental units... (AU)


La importancia de la permanencia de los dientes naturales en la cavidad bucal ha sido cada vez más reconocida y buscada, ya sea por motivos estéticos o funcionales. Una alternativa para la rehabilitación de personas con pérdida de dientes o extracciones recomendadas es el trasplante dental. Esta modalidad de tratamiento corresponde a la transferencia de un órgano dentario a un alvéolo receptor. Este trabajo reporta y discute un caso de triple trasplante autógeno, utilizando terceros molares, enfatizando los pasos quirúrgicos y demostrando que luego de dos años de preservación, los resultados confirman el éxito de este tratamiento. Se analizó cuidadosamente la anamnesis, los exámenes clínicos y radiográficos, antes y después de la cirugía, con radiografía panorámica antes y después de la cirugía y radiografías periapicales después, para el seguimiento individual de las unidades trasplantadas. Los trasplantes dentales fueron exitosos, logrando la regeneración pulpar y la adaptación al alvéolo receptor, manteniendo el espacio dentario con una oclusión y vitalidad dentarias satisfactorias. El procedimiento fue significativamente exitoso, teniendo éxito en las tres unidades trasplantadas, devolviendo el equilibrio al desarrollo craneofacial, demostrando su efectividad en la rehabilitación oral en jóvenes con pérdida prematura de unidades dentales... (AU)


Subject(s)
Humans , Female , Adolescent , Transplantation, Autologous , Molar, Third , Molar, Third/surgery , Mouth Rehabilitation , Radiography, Panoramic , Aftercare , Dental Occlusion
20.
Hematol., Transfus. Cell Ther. (Impr.) ; 43(4): 402-409, Oct.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1350819

ABSTRACT

ABSTRACT Introduction: To study the efficacy and safety of single large volume leukapheresis by using generic G-CSF or G-CSF plus Plerixafor in achieving adequate stem cell yield and various factors influencing thereof in newly diagnosed multiple myeloma patients undergoing autologous stem cell transplant . Method: This prospective study was undertaken among 55 newly diagnosed multiple myeloma patients undergoing autologous stem cell transplant and aged between 18 and 75 years. Mobilization and harvesting of stem cells were performed by using GCSF or GCSF plus Plerixafor and large volume leukapheresis, respectively. A stem cell yield of ≥2 × 106 kg-1 and the number of apheresis procedures were primary efficacy endpoints, while the ideal stem cells yield >5 × 106 kg-1, the engraftment day and D100 response/graft sustainability were secondary endpoints. Result: The primary endpoint was achieved in all cases in both the groups by using a single LVL leukapheresis procedure. Fulfillment of all the secondary endpoints was satisfactory and comparable in both the groups. Age, pre-apheresis CD34+ count and number of interruptions during the LVL were significant factors influencing the stem cell yield (p < 0.05). Adverse drug reactions during the apheresis and post-ASCT period were manageable. Conclusion: The LVL is safe and cost-effective in attaining a minimum of CD34+ cells in a single procedure with manageable adverse reactions. Judicious intervention during the procedure may be helpful in ensuring the adequate yield.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Stem Cell Transplantation , Multiple Myeloma/diagnosis , Multiple Myeloma/drug therapy , Transplantation, Autologous , Leukapheresis , Receptors, CXCR4/antagonists & inhibitors
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