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1.
Femina ; 49(6): 379-384, 20210630.
Article in Portuguese | LILACS | ID: biblio-1290571

ABSTRACT

O objetivo deste trabalho foi analisar os aspectos emocionais presentes no processo de reprodução humana assistida (RHA), por meio de uma revisão interativa da literatura. As bases de dados utilizadas foram PubMed, BVS e Periódicos Capes, com os descritores "infertility" AND "reproductive techniques" AND "emotions". Foram incluídos e analisados 24 artigos dos últimos cinco anos (2015 a 2020). Os resultados indicam que existem diversos sentimentos negativos que permeiam os casais infé rteis, especialmente quando existem falhas no tratamento. O apoio social durante o tratamento em RHA melhora a qualidade de vida do casal e diminui o sofrimento emocional. As estratégias de enfrentamento utilizadas pelos casais inférteis e as intervenções terapêuticas também foram avaliadas como positivas para o manejo do estresse, da ansiedade e da depressão. As diferenças de gênero apareceram nos estudos e reiteram a relevância das relações de gênero, indicando a necessidade de intervenções diferentes para homens e mulheres.(AU)


The aim of this work was to analyze the emotional aspects present in the assisted human reproduction (RHA) process, through an interactive literature review. The databases used were PUBMED, BVS and CAPES journals, with the descriptors "infertility" AND « reproductive techniques" AND "emotions." 24 articles from the last five years (2015 to 2020) were included and analyzed. The results indicate that there are several negative feelings that permeate infertile couples, especially when treatment failures, social support during RHA treatment improves the couple's quality of life and reduces emotional distress. The coping strategies used by infertile couples and interventions therapeutics were also evaluated as positive for the management of stress, anxiety and depression. The gender differences appeared in the studies and reiterate the relevance of gender relations, indicating the need for different interventions for men and women.(AU)


Subject(s)
Humans , Male , Female , Reproductive Techniques, Assisted/psychology , Psychological Distress , Infertility/psychology , Infertility/therapy , Social Support , Adaptation, Psychological , Databases, Bibliographic , Treatment Outcome , Treatment Failure
2.
J. coloproctol. (Rio J., Impr.) ; 41(1): 42-46, Jan.-Mar. 2021. tab
Article in English | LILACS | ID: biblio-1286973

ABSTRACT

Abstract Introduction Colorectal cancer is the second most common type of cancer and the third leading cause ofmortality due to cancers. Anastomosis leak after proctectomy is a dangerous complication that must be managed carefully. The aim of the present study was to assess the procedure of resection and pull-through of the new rectum after anastomosis leak in patients after proctectomy. Methods and Materials This was a cross-sectional study. Patients who visited the Firoozgar Hospital between 2015 and 2018 for rectal cancer surgery and had anastomosis leak entered the study. All patients underwent resection of the residue of rectum and pull-through of colon. Results In the present study, out of the 110 cases who underwent proctectomy, 12 patients with postoperative anastomosis leak were reported. Five (41.7%) were male and 7 (58.3%) were female. Themean age of the patients was 41.5 ± 4.3 years (33-51). Resection of the new rectum and pull-through anastomosis were performed for these 12 patients. No major intraoperative complication occurred. Postoperative course was uneventful in all patients. Discussion Resection of residue of rectum and pull-through in patients with anastomosis leak can be done after rectal cancer surgery. This method is superior to abdominopelvic resection in many aspects, especially regarding accessibility to the new rectum by rectal exam or endosonography to assess recurrence or a relative continence after closure of ostomy.


Resumo Introdução O câncer colorretal é o segundo tipo de câncer mais comum, e a terceira principal causa de mortalidade por câncer. O vazamento da anastomose após a proctectomia é uma complicação perigosa, que deve ser tratada com cuidado. O objetivo do presente estudo foi avaliar o procedimento de ressecção e abaixamento do novo reto após vazamento de anastomose em pacientes submetidos à proctectomia. Métodos e Materiais Este foi um estudo transversal que incluiu pacientes que compareceram ao Firoozgar Hospital entre 2015 e 2018 submetidos a cirurgia de câncer retal e com vazamento de anastomose. Todos os pacientes foram submetidos a ressecção do resíduo do reto e abaixamento do cólon. Resultados No presente estudo, dos 110 casos submetidos a proctectomia, 12 pacientes tiveram vazamento de anastomose pós-operatório: 5 (41,7%) do sexo masculino e 7 (58,3%) do sexo feminino. A idade média dos pacientes foi de 41,5 ± 4,3 anos (gama: 33 a 51 anos). A ressecção do reto novo e a anastomose por abaixamento foram realizadas nesses 12 pacientes. Nenhuma complicação intraoperatória mais grave ocorreu. No pós-operatório, não houve intercorrências em nenhum dos pacientes. Discussão A ressecção de resíduo retal e o abaixamento em pacientes com vazamento de anastomose pode ser feita após cirurgia de câncer retal. Este método é superior à ressecção abdominopélvica em muitos aspectos, especialmente quanto à acessibilidade ao novo reto por exame retal ou endossonografia para avaliar a recorrência ou uma continência relativa após o fechamento da ostomia.


Subject(s)
Humans , Male , Female , Adult , Rectum/surgery , Treatment Failure , Colon/surgery , Proctectomy/adverse effects , Rectal Neoplasms/complications , Anastomosis, Surgical , Cross-Sectional Studies
4.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 13: 1142-1147, jan.-dez. 2021. tab
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1255126

ABSTRACT

Objetivo: Descrever características demográficas, clínicas, da terapia intravenosa prévia e cateterização intravenosa periférica em crianças com câncer e insucesso do procedimento. Método: trata-se de um estudo descritivo do tipo transversal, realizado com 18 crianças com insucesso da punção intravenosa periférica, internadas na clínica oncológica pediátrica do Hospital Estadual da Criança, em Feira de Santana-Bahia, entre Abril de 2015 e Dezembro de 2016. Resultados:evidenciou-se o insucesso em 11,7% das crianças. A maioria tinha 01 a 49 meses, pardas, sexo masculino, eutróficas, e o principal motivo de insucesso foi transfixação da veia. Os fatores predisponentes relativos ao insucesso foram história de dificuldade de inserção de cateter intravenoso periférico, complicação anterior à terapia intravenosa, internação anterior e antecedente de infiltração. Conclusão: o percentual de insucesso da punção intravenosa periférica é semelhante aos valores encontrados em estudos sobre o contexto, relacionado com o perfil das crianças, a terapia utilizada, e os fatores predisponentes


Objective:To describe demographic, clinical, prior intravenous therapy and peripheral intravenous catheterization characteristics in children with cancer and procedural failure. Method: this is a cross-sectional descriptive study of 18 children with peripheral intravenous puncture failure hospitalized at the pediatric oncology clinic of Hospital Estadual da Criança, in Feira de Santana-Bahia, between April 2015 and December 2016 Results: failure was observed in 11.7% of the children. The majority were 01 to 49 months, brown, male, eutrophic, and the main reason for failure was transfixation of the vein. The predisposing factors related to failure were a history of difficulty in insertion of a peripheral intravenous catheter, a complication prior to intravenous therapy, previous hospitalization and previous infiltration. Conclusion:the percentage of failure of the peripheral intravenous puncture is similar to the values found in studies on the context, related to the profile of the children, the therapy used, and the predisposing factors


Objetivo: Describir características demográficas, clínicas, de la terapia intravenosa previa y cateterización intravenosa periférica en niños con cáncer y fracaso del procedimiento. Método: se trata de un estudio descriptivo del tipo transversal, realizado con 18 niños con fracaso de la punción intravenosa periférica, internados en la clínica oncológica pediátrica del Hospital Estadual del Niño, en Feira de Santana-Bahía, entre abril de 2015 y diciembre de 2016. Resultados: se evidenció el fracaso en el 11,7% de los niños. La mayoría tenía entre 01 y 49 meses, pardas, sexo masculino, eutróficas, y el principal motivo de fracaso fue la transfixación de la vena. Los factores predisponentes relativos al fracaso fueron historia de dificultad de inserción de catéter intravenoso periférico, complicación anterior a la terapia intravenosa, internación anterior y antecedente de infiltración. Conclusión: el porcentaje de fracaso de la punción intravenosa periférica es similar a los valores encontrados en estudios sobre el contexto, relacionado con el perfil de los niños, la terapia utilizada, y los factores predisponentes


Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Infusions, Intravenous , Catheterization, Peripheral , Treatment Failure , Neoplasms/therapy , Cross-Sectional Studies , Patient Safety
5.
Article in Chinese | WPRIM | ID: wpr-880130

ABSTRACT

OBJECTIVE@#To analyze the efficacy of CCLG-ALL-2008 protocol and the related factors of treatment failure in children with acute lymphoblastic leukemia (ALL).@*METHODS@#The clinical data of 400 children newly-diagnosed ALL in Children's Hospital of Soochow University from March 1, 2008 to December 31, 2012 was retrospectively analyzed. All the children accepted CCLG-ALL-2008 protocol, and were followed-up until October 2019. The dates of relapse, death and causes of death were recorded. Treatment failure was defined as relapse, non-relapse death, and secondary tumor.@*RESULTS@#Following-up for 10 years, there were 152 cases relapse or non-relapse death, the treatment failure rate was 38%, including 122 relapse (80.3%), 30 non-relapse deaths (19.7%) which included 7 cases (4 cases died of infection and 3 cases died of bleeding) died of treatment (23.3% of non-relapse deaths), 8 cases died of minimal residual disease (MRD) continuous positive (26.7% of non-relapse deaths) and 15 cases died of financial burden (50% of non-relapse deaths). According to the relapse stage, 37 cases (30%) in very early stage, 38 cases (31%) in early stage, and 47 cases (39%) in late stage, while according to the relapse site, 107 cases relapsed in bone marrow, 3 cases in testis, 3 cases in central nervous system (CNS), 5 cases in bone marrow plus testis and 4 cases in bone marrow plus CNS. Bone marrow relapse was the main cause of death in 89 cases, followed by nervous system. Initially diagnosed WBC count (≥50×10@*CONCLUSION@#Relapse is the main cause of treatment failure in children with ALL. The initially diagnosed WBC count, immunophenotype and MRD at week 12 were the independent prognostic factors for relapse of the patients. Financial burden accounts for a large proportion of non-relapse death.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols , Child , Disease-Free Survival , Humans , Male , Neoplasm, Residual , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Prognosis , Recurrence , Retrospective Studies , Treatment Failure , Treatment Outcome
6.
Rev. chil. infectol ; 37(5): 550-554, nov. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1144249

ABSTRACT

Resumen Introducción: Cargas virales (CV) entre 20-200 copias/mL se consideran cargas virales de bajo grado (CVBG). Su implicancia clínica y manejo no han sido definidos. Objetivo: Evaluar el impacto de CVBG en el riesgo de desarrollo posterior de fallo virológico (FV). Pacientes y Métodos: Se incluyeron pacientes ≥ 18 años, desde enero de 2009 a diciembre de 2019, con infección por VIH-1 con CV< 20 copias/mL, por un mínimo de seis meses y/o en dos muestras consecutivas bajo tratamiento anti-retroviral . Se realizó seguimiento de las CV estrati ficándolas: CV < 20 copias/mL, CVBG (20-50 copias/mL y 51-200 copias/mL) y FV. Mediana de seguimiento 25 meses (IQR 15-31). Resultados: Fueron incluidos 1.416 pacientes con CV < 20 copias/ mL bajo TARV. De ellos, 797 permanecieron con CV< 20 copias/mL durante el seguimiento, 144 presentaron CV entre 20-50 copias/mL, 384 entre 51-200 copias/mL y 91 presentaron FV sin CVBG previa. De los 528 pacientes que tuvieron CVBG, 110 (20,1%) fallaron, riesgo 3,45 veces superior respecto a los que no tuvieron CVBG previa. El riesgo de FV fue 3,27 mayor para aquellos que tuvieron CVBG entre 51-200 copias/mL vs 20-50 copias/mL. Discusión: El estudio permite relacionar la CVBG con el FV posterior, siendo el mayor riesgo CVBG entre 51-200 copias/mL.


Abstract Background: Viral loads (VL) between 20-200 copies/mL are considered low-grade viral loads (LGVL). Its clinical implications and management have not been defined. Aim: To evaluate the impact of LGVL on the risk of subsequent development of virological failure (VF). Methods: Patients ≥ 18 years, with HIV-1 infection who had VL < 20 copies/mL for at least six months and/or in two consecutive samples under antiretroviral therapy (ART) were included, between January 1st, 2009 and December 31, 2019. Follow-up of the VLs was carried out stratifying them in VL < 20 copies/mL, LGVL (20-50 copies/mL and 51-200 copies/mL) and VF. Median follow-up 25 months (IQR 15-31). Results: 1,416 patients were included who reached VL < 20 copies/ml under ART, 797 patients remained with CV < 20 copies/mL during follow-up, 144 patients had VL between 21-50 copies/mL, 384 between 51-200 copies/mL and 91 had VF without previous LGVL. Out of 528 patients who had LGVL, 110 failed, risk 3.45 times higher than those who had no previous LGVL. Risk 3.27 times higher of VF for those who had LGVL between 51-200 copies/mL compared to 20-50 copies/mL. Discussion: The study allows to relate the LGVL with VF. This association was observed more frequently with LGVL between 51-200 copies/mL


Subject(s)
Humans , Viremia/etiology , HIV Infections/complications , HIV Infections/drug therapy , HIV-1 , Treatment Failure , Anti-HIV Agents/therapeutic use , Viral Load , Antiretroviral Therapy, Highly Active
7.
Rev. chil. pediatr ; 91(3): 391-397, jun. 2020. tab
Article in Spanish | LILACS | ID: biblio-1126177

ABSTRACT

Resumen: Introducción: En pacientes con Síndrome de Hipoplasia de Ventrículo Izquierdo (SHVI) la primera etapa hacia una fisiología univentricular de Fontan es la operación de Norwood, cuya mortalidad es 10-30%. En estos pacientes la extubación fallida se presenta en un 18% y se ha asociado a aumento de la mortali dad. Objetivo: Describir la frecuencia de extubación fallida y sus factores de riesgo en pacientes con SHVI operados (Norwood). Pacientes y Método: Estudio de casos y controles que incluyó a todos los pacientes con SHVI manejados con cirugía de Norwood en el Hospital Clínico de la Pontificia Universidad Católica (enero-2000 a febrero-2018). Se define como casos a pacientes con falla en la extubación y como controles a los pacientes sin esta complicación. Se registraron variables demográficas, quirúrgicas, y post-quirúrgicas, y se realizó análisis univariado y multivariado (regresión logística) para determinar los factores de riesgo asociados a la falla en la extubación. Resultados: De un total de 107 pacientes, 26 pacientes tuvieron extubación fallida (24,3%). En el análisis univariado los factores asociados a extubación fallida fueron: mayor tiempo de ventilación mecánica postquirúrgico, desarrollar atelectasias, derrame pleural, quilotórax, tener otras comorbilidades respiratorias (apnea y traqueítis), y mayor tiempo de uso de morfina y midazolam. En el análisis multivariado, la presencia de quilotórax, otras comorbilidades respiratorias, y mayor tiempo de uso de midazolam fueron variables asociadas a extubación fallida (p<0,03). La extubación fallida no se asoció a mayor mortalidad. Conclusiones: La presencia de quilotórax, complicaciones respiratorias y uso de mida zolam prolongado deben considerarse para definir el momento de la extubación, con el objetivo de evitar su fracaso.


Abstract: Introduction: Hypoplastic left heart syndrome (HLHS) is the main cause of mortality due to congenital heart disea se. The Norwood surgery is the first procedure of the surgical staging process towards a single ventri cle physiology or Fontan-type operation and has a mortality rate of 10% to 30%. Extubation failure during the postoperative period occurs in up to 18% of these patients and is associated with increased mortality. Objective: To describe extubation failure rates and risk factors in pediatric patients with HLHS who underwent Norwood procedure. Patients and Method: Case-control study that included all the patients with HLHS managed with Norwood surgery at the Hospital Clínico de la Pontificia Universidad Catolica between January 2000 and February 2018. Cases and controls were defined as patients with extubation failure and as patients without this complication, respectively. The following variables were recorded demographic, surgical, and post-surgical ones, and univariate and multivariate analyses (logistic regression) were performed to determine risk factors associated with extubation failure. Results: Out of 107 patients, 26 of them presented extubation failure (24.3%). In the univariate analysis, longer mechanical ventilation time during the postsurgical period, atelectasis, pleural effusion, chylothorax, other respiratory morbidities (i.e. apneas and tracheitis), and longer infusion times of morphine and midazolam, all were associated with a higher extubation failure rate in this population. In the multivariable analysis, chylothorax, other respiratory comorbidities, and longer infusion time of midazolam remained associated with this complication, however, it was not associated with higher mortality. Conclusions: Chylothorax, respiratory comorbidities, and longer use of Midazolam should be addressed before planning airway extubation in order to avoid failure.


Subject(s)
Humans , Male , Female , Infant, Newborn , Postoperative Care/statistics & numerical data , Hypoplastic Left Heart Syndrome/surgery , Norwood Procedures , Airway Extubation/statistics & numerical data , Postoperative Care/methods , Postoperative Complications/etiology , Postoperative Complications/therapy , Postoperative Complications/epidemiology , Case-Control Studies , Logistic Models , Retrospective Studies , Risk Factors , Treatment Failure
8.
Medicina (B.Aires) ; 80(2): 111-116, abr. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1125050

ABSTRACT

La resistencia bacteriana a ciertos antibióticos condiciona el éxito del tratamiento erradicador de la infección gástrica por Helicobacter pylori y es motivo de creciente preocupación a nivel mundial. Dada la escasa evidencia publicada en Argentina sobre este tema, nuestro objetivo fue investigar factores asociados a la persistencia de H. pylori post-tratamiento antibiótico. Se determinó la frecuencia de fracaso terapéutico en 81 pacientes con gastritis por H. pylori tratados en nuestro Servicio y sometidos al estudio de urea en aire espirado para confirmar la erradicación de la infección. La edad promedio fue 58±12 y 43.2% eran hombres. La frecuencia de fracaso terapéutico fue 17.3%. De los dos esquemas más utilizados, la frecuencia de fracaso fue mayor con claritromicina + amoxicilina que con levofloxacina + amoxicilina (25% vs. 6.6%, p=0.04). Como factores de riesgo investigamos las siguientes variables: edad, género, síntomas, tabaquismo, consumo de anti-inflamatorios, diabetes, obesidad, tipo y duración de tratamiento. En el análisis univariado, el uso de esquemas con claritromicina y el género masculino se asociaron significativamente a persistencia de la infección [OR 4.2 (1.1-15.6) y 5.2 (1.1-26.4)]. En el análisis multivariado, el uso de esquema con claritromicina permaneció asociado al fracaso terapéutico [OR 5.38 (1.1-29.5)]. Concluimos que la inclusión de claritromicina en el esquema terapéutico para la gastritis por H. pylori se asoció a mayor fracaso terapéutico. Este fracaso es atribuible a alta prevalencia de resistencia de H. pylori a ese antibiótico en la población atendida en nuestro hospital y cuestiona las prácticas habituales de tratamiento en nuestro medio.


Antibiotic resistance may hinder the efficacy of eradication therapy against Helicobacter pylori infection and it has become a major concern worldwide. Due to the relatively scarce evidence published in Argentina on this topic, our aim was to describe factors associated with H. pylori persistence after antibiotic treatment. The therapeutic failure rate was described among 81 patients with H. pylori gastritis treated in our Hospital with a post-treatment urea breath test to determine successful eradication. Mean age was 58 ± 12 and 43.2% were male subjects. H. pylori persistence was observed in 17.3% of subjects. Therapeutic failure was more common among patients receiving clarithromycin + amoxicillin therapy that among those receiving levofloxacin + amoxicillin (25% vs. 6.6%, p = 0.04). The following variables were assessed: age, gender, referral symptoms, smoking, anti-inflammatory use, diabetes, obesity, treatment type and duration. Clarithromycin-based therapy and male gender were associated with infection persistence on univariate analysis [OR 4.2 (1.1-15.6) and 5.2 (1.1-26.4)]. On multivariate analysis, clarithromycin-based was associated with infection persistence [5.38 (1.1-29.5)]. We conclude that clarithromycin-based therapy is significantly associated with treatment failure. This failure may be due to an elevated prevalence of H. pylori resistance to clarithromycin in the population under study and raises the question on the utility of such therapeutic alternative.


Subject(s)
Humans , Male , Female , Middle Aged , Helicobacter Infections/drug therapy , Drug Resistance, Bacterial , Gastritis/drug therapy , Anti-Bacterial Agents/therapeutic use , Argentina , Cross-Sectional Studies , Retrospective Studies , Helicobacter pylori , Helicobacter Infections/microbiology , Treatment Failure , Clarithromycin/therapeutic use , Drug Therapy, Combination , Levofloxacin/therapeutic use , Gastritis/microbiology , Amoxicillin/therapeutic use
9.
Fisioter. Pesqui. (Online) ; 27(1): 34-40, jan.-mar. 2020. tab, graf
Article in Portuguese | LILACS | ID: biblio-1090406

ABSTRACT

RESUMO Na unidade de terapia intensiva (UTI) pediátrica, a falha de extubação pode aumentar o risco de mortalidade. Este estudo objetivou: (1) verificar a taxa de falha de extubação na UTI pediátrica de um hospital público do município de Bauru (São Paulo, Brasil); (2) identificar a principal causa atribuída à falha de extubação; (3) avaliar se características como a idade e o tempo de ventilação mecânica invasiva (VMI) estão associadas à falha de extubação; (4) avaliar se o tempo de permanência na UTI e hospital é maior entre os pacientes que apresentaram falha de extubação. Foi realizado estudo de coorte retrospectivo com 89 pacientes internados de maio de 2017 até julho de 2018. Os resultados mostraram taxa de falha de extubação correspondente a 16%. A principal causa atribuída à falha de extubação foi o estridor laríngeo, totalizando 57% dos casos. A comparação intergrupos (sucesso vs. falha de extubação) não mostrou diferenças em relação à idade (p=0,294) e ao tempo de VMI (p=0,228). No entanto, observamos que o grupo falha de extubação apresentou maior tempo de UTI (p=0,000) e hospital (p=0,010). Desta forma, concluímos que a taxa de extubação está de acordo com a observada em outros estudos. O estridor laríngeo foi responsável por mais da metade dos casos de falha de extubação. Embora a idade e o tempo de VMI não tenham sido características associadas à falha de extubação, esta contribuiu para o maior período de permanência na UTI e no hospital.


RESUMEN En la unidad de cuidados intensivos (UCI) pediátrica, el fracaso de la extubación puede aumentar el riesgo de mortalidad. Este estudio tuvo el objetivo de: (1) verificar el índice de fracaso de la extubación en la UCI pediátrica de un hospital público en el municipio de Bauru (São Paulo, Brasil); (2) identificar la causa principal atribuida al fracaso de la extubación; (3) evaluar si las características edad y tiempo de ventilación mecánica invasiva (VMI) están asociadas al fracaso de la extubación; (4) evaluar si la duración en la UCI y el hospital es mayor entre los pacientes que experimentaron este fracaso. Se realizó un estudio de cohorte retrospectivo con 89 pacientes hospitalizados desde mayo de 2017 hasta julio de 2018. Los índices del fracaso de la extubación fueron del 16%. El estridor laríngeo fue la causa principal atribuida al fracaso de la extubación, lo que totaliza el 57% de los casos. La comparación intergrupal (éxito versus fracaso de la extubación) no presentó diferencias en relación con la edad (p=0,294) y el tiempo VMI (p=0,228). Se observó que el grupo fracaso de la extubación estuvo más tiempo en la UCI (p=0,000) y el hospital (p=0,010). Se concluye que el índice de extubación está en consonancia con lo observado en otros estudios. El estridor laríngeo fue el responsable de más de la mitad de los casos de fracaso de la extubación. Las características edad y el tiempo de VMI no estuvieron asociadas al fracaso de la extubación, pero esta contribuyó a un período más prolongado en la UCI y en el hospital.


ABSTRACT In the pediatric intensive care unit (ICU), extubation failure may increase mortality risk. This study aimed: (1) to verify the rate of extubation failure in the pediatric ICU of a public hospital located in the city of Bauru (São Paulo, Brazil); (2) to identify the main cause attributed to extubation failure; (3) to evaluate whether age and time of invasive mechanical ventilation (IMV) are characteristics associated to extubation failure; (4) to evaluate whether the length of stay in the ICU/hospital is longer among patients who presented extubation failure. A retrospective study was performed with 89 hospitalized patients from May 2017 to July 2018. Results showed an extubation failure rate corresponding to 16%. The main cause attributed to extubation failure was laryngeal stridor, totaling 57% of the cases. Intergroup comparison (success vs. failure of extubation) showed no differences in relation to age (p=0.294) and IMV time (p=0.228). However, we observed that the extubation failure group had longer ICU (p=0.000) and hospital time (p=0.010). In this way, we conclude that the rate of extubation failure is in agreement with other studies. Laryngeal stridor was responsible for more than half of cases of extubation failure. Although IMV time and age were not associated with the extubation failure, they contributed to a longer stay in the ICU and in the hospital.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Respiration, Artificial/adverse effects , Intensive Care Units, Pediatric/statistics & numerical data , Airway Extubation/adverse effects , Respiration, Artificial/statistics & numerical data , Time Factors , Respiratory Sounds/etiology , Retrospective Studies , Risk Factors , Cohort Studies , Age Factors , Treatment Failure , Electronic Health Records , Airway Extubation/statistics & numerical data , Length of Stay
11.
Einstein (Säo Paulo) ; 18: e0AO5052, 2020. graf
Article in English | LILACS | ID: biblio-1090065

ABSTRACT

ABSTRACT Objective To compare screw fixation strength for subtalar arthrodesis. Methods Eight matched pairs of cadaver feet underwent subtalar joint arthrodesis with two 7.3mm cannulated screws. Randomization was used to assign screw orientation, such that one foot in each pair was assigned dorsal to plantar screw orientation (DP Group), and the other foot, plantar to dorsal orientation (PD Group). Standard surgical technique with fluoroscopy was used for each approach. Following fixation, each specimen was loaded to failure with a Bionix ® 858 MTS device, applying a downward axial force at a distance to create torque. Torque to failure was compared between DP and PD Groups using Student's t test, with p=0.05 used to determine statistical significance. Results Statistical analysis demonstrated that the mean torque to failure slightly favored the DP Group (37.3Nm) to the PD Group (32.2Nm). However, the difference between the two groups was not statistically significant (p=0.55). Conclusion In subtalar arthrodesis, there is no significant difference in construct strength between dorsal-to-plantar and plantar-to-dorsal screw orientation. The approach chosen by the surgeon should be based on factors other than the biomechanical strength of the screw orientation.


RESUMO Objetivo Comparar a força de fixação dos parafusos para artrodese subtalar. Métodos Oito pares de pés de cadáveres frescos foram submetidos à artrodese da articulação subtalar com dois parafusos canulados de 7,3mm. A randomização foi usada para atribuir a orientação do parafuso, de modo que um pé em cada par foi designado com orientação de dorsal para plantar (Grupo DP), e o outro pé com orientação de plantar para dorsal (Grupo PD). Técnica cirúrgica padrão com radioscopia foi usada para os procedimentos. Após a fixação, cada amostra foi testada até a falha com um dispositivo Bionix®858 MTS, aplicando força axial descendente a uma distância para criar torque. O torque de falha foi comparado entre os Grupos DP e PD, usando o teste t de Student, com p=0,05 usado para determinar significância estatística. Resultados A análise estatística demonstrou que a média do torque até a falha favoreceu ligeiramente o Grupo DP (37,3Nm) em relação ao PD (32,2Nm). No entanto, a diferença entre os dois grupos não foi estatisticamente significativa (p=0,55). Conclusão Na artrodese subtalar, não há diferença significativa na força de compressão entre as orientações dos parafusos dorsal-plantar e plantar-dorsal. A abordagem escolhida pelo cirurgião deve ser baseada em outros fatores, sem preocupação com a força biomecânica da orientação dos parafusos.


Subject(s)
Humans , Arthrodesis/methods , Bone Screws , Subtalar Joint/surgery , Arthrodesis/instrumentation , Biomechanical Phenomena , Cadaver , Calcaneus/surgery , Talus/surgery , Reproducibility of Results , Treatment Failure , Torque
12.
Rev. latinoam. enferm. (Online) ; 28: e3334, 2020. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1126991

ABSTRACT

Objective: to clinically validate the nursing diagnosis of Dysfunctional Ventilatory Weaning Response in adult patients admitted to Intensive Care Units. Method: a concurrent cohort performed with 93 patients admitted to Intensive Care Units. The incidence and incidence density of the diagnosis were estimated, its related factors were identified based on bivariate analysis and clinical indicators for determining its occurrence, according to the global and temporal presentation. Results: the overall incidence of the diagnosis was 44.09% and the incidence density was 14.49 occurrences for every 100 extubations/day. The factors related to the diagnosis were the following: age, clinical severity, fluid balance, oliguria, hemodialysis, edema in upper/lower limbs, anasarca, number of antibiotics, hypothermia, hyperthermia, amount of secretion, muscle retraction, anxiety score, heart rate, use of vasopressors and non-invasive ventilation after extubation. The clinical indicators most frequently identified for determining the diagnosis were the following: tachypnea, drop of saturation and tachycardia. Temporal progression in the severity of these manifestations was found. Conclusion: the Dysfunctional Ventilatory Weaning Response is a common finding in critically ill patients. Some components of the diagnosis of the NANDA-International (2018) version could be clinically validated. It is noteworthy that there are variables not yet described in the taxonomy, demonstrating the need to review this nursing diagnosis.


Objetivo: validar clinicamente o diagnóstico de enfermagem Resposta Disfuncional ao Desmame Ventilatório em pacientes adultos internados em Unidades de Terapia Intensiva. Método: coorte concorrente realizada com 93 pacientes internados em Unidades de Terapia Intensiva. Foram estimadas a incidência e a densidade de incidência do diagnóstico, identificados seus fatores relacionados a partir de análise bivariada e indicadores clínicos de determinação da sua ocorrência, segundo apresentação global e temporal. Resultados: a incidência global do diagnóstico foi de 44,09% e a densidade de incidência de 14,49 ocorrências a cada 100 extubações/dia. Os fatores relacionados ao diagnóstico foram: idade, gravidade clínica, balanço hídrico, oligúria, hemodiálise, edema em membros superiores/inferiores, anasarca, número de antibióticos, hipotermia, hipertermia, quantidade de secreção, retração muscular, escore de ansiedade, frequência cardíaca, uso de vasopressores e ventilação não invasiva após a extubação. Os indicadores clínicos identificados mais frequentemente para a determinação do diagnóstico foram: taquipneia, queda de saturação e taquicardia. Verificou-se progressão temporal da gravidade dessas manifestações. Conclusão: a Resposta Disfuncional ao Desmame Ventilatório é um achado comum em pacientes críticos. Alguns componentes do diagnóstico da versão NANDA-International (2018) puderam ser validados clinicamente. Destaca-se que existem variáveis ainda não descritas na taxonomia, demonstrando a necessidade de revisão desse diagnóstico de enfermagem.


Objetivo: validar clínicamente el diagnóstico de enfermería Respuesta Ventilatoria Disfuncional al Destete en pacientes adultos internados en Unidades de Cuidados Intensivos. Método: cohorte concurrente realizada con 93 pacientes internados en Unidades de Cuidados Intensivos. Se estimó la incidencia y densidad de incidencia del diagnóstico y se identificaron los factores vinculados a partir de análisis bivariados e indicadores clínicos para determinar su ocurrencia, de acuerdo con la presentación global y temporal. Resultados: la incidencia global del diagnóstico fue de 44,09% y la densidad de incidencia de 14,49 casos por cada 100 extubaciones/día. Los factores relacionados con el diagnóstico fueron: edad, gravedad clínica, balance hídrico, oliguria, hemodiálisis, edema en miembros superiores/inferiores, anasarca, número de antibióticos, hipotermia, hipertermia, cantidad de secreción, retracción muscular, grado de ansiedad, frecuencia cardíaca, uso de vasopresores y ventilación no invasiva después de la extubación. Los indicadores clínicos identificados con mayor frecuencia para determinar el diagnóstico fueron: taquipnea, disminución de la saturación de oxígeno y taquicardia. Se verificó una progresión temporal en la gravedad de estas afecciones. Conclusión: La Respuesta Ventilatoria Disfuncional al Destete es un hallazgo común en pacientes críticos. Algunos componentes del diagnóstico de la versión NANDA-International (2018) podrían validarse clínicamente. Es de destacar que hay variables aún no descriptas en la taxonomía, lo que demuestra la necesidad de revisar este diagnóstico de enfermería.


Subject(s)
Humans , Male , Female , Adult , Vasoconstrictor Agents , Nursing Diagnosis , Ventilator Weaning , Nursing , Treatment Failure , Validation Study , Airway Extubation , Noninvasive Ventilation , Intensive Care Units
13.
Article in English | WPRIM | ID: wpr-811147

ABSTRACT

BACKGROUND: There is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that is inadequately controlled using dual combination therapy. This study assessed the efficacy and safety of pioglitazone or glimepiride when added to metformin plus alogliptin treatment for T2DM.METHODS: This multicenter, randomized, active-controlled trial (ClinicalTrials.gov: NCT02426294) recruited 135 Korean patients with T2DM that was inadequately controlled using metformin plus alogliptin. The patients were then randomized to also receive pioglitazone (15 mg/day) or glimepiride (2 mg/day) for a 26-week period, with dose titration was permitted based on the investigator's judgement.RESULTS: Glycosylated hemoglobin levels exhibited similar significant decreases in both groups during the treatment period (pioglitazone: −0.81%, P<0.001; glimepiride: −1.05%, P<0.001). However, the pioglitazone-treated group exhibited significantly higher high density lipoprotein cholesterol levels (P<0.001) and significantly lower homeostatic model assessment of insulin resistance values (P<0.001). Relative to pioglitazone, adding glimepiride to metformin plus alogliptin markedly increased the risk of hypoglycemia (pioglitazone: 1/69 cases [1.45%], glimepiride: 14/66 cases [21.21%]; P<0.001).CONCLUSION: Among patients with T2DM inadequately controlled using metformin plus alogliptin, the addition of pioglitazone provided comparable glycemic control and various benefits (improvements in lipid profiles, insulin resistance, and hypoglycemia risk) relative to the addition of glimepiride.


Subject(s)
Cholesterol, HDL , Diabetes Mellitus, Type 2 , Dipeptidyl-Peptidase IV Inhibitors , Drug Therapy, Combination , Glycated Hemoglobin A , Humans , Hypoglycemia , Insulin Resistance , Metformin , Sulfonylurea Compounds , Thiazolidinediones , Treatment Failure
14.
Article in English | WPRIM | ID: wpr-810969

ABSTRACT

BACKGROUND: Long-term administration of ethambutol (EMB) for Mycobacterium avium complex lung disease (MAC-LD) sometimes leads to permanent discontinuation of EMB due to various adverse events. This study aimed to investigate treatment outcomes after discontinuation of EMB.METHODS: Among patients diagnosed with MAC-LD between January 2001 and December 2014, 508 patients whose treatment was initiated with standard regimen until May 2018 were enrolled at a tertiary referral center in Korea. Of these 508 patients, 60 (11.8%) discontinued EMB due to various adverse effects. Among these 60 patients, treatment outcomes were analyzed for 44 patients by comparing their outcomes with those of matched subjects who received the standard treatment regimen without EMB discontinuation.RESULTS: The mean age of the 60 patients who discontinued EMB was 64.4 years. Ocular toxicity was the most common cause of discontinuation of EMB (75.0%, 45/60). The mean duration of EMB administration before its discontinuation was 7.0 ± 4.6 months. The treatment failure rate of the 44 patients with EMB discontinuation analyzed for treatment outcome was 29.6%, which was higher than that of the matched patients who received the standard regimen (18.3%), although the difference was not significant (P = 0.095). Of these 44 patients, EMB was substituted with later-generation fluoroquinolone in 23 patients, and the treatment failure rate of these 23 patients was significantly higher than that of the matched patients who received the standard regimen (39.1% vs. 19.3%, P = 0.045).CONCLUSION: These findings suggest that treatment outcomes are unsatisfactory in patients with MAC-LD who discontinue EMB owing to adverse events. Notably, there was a statistically significant high failure rate in patients who were prescribed fluoroquinolone to replace EMB.


Subject(s)
Ethambutol , Fluoroquinolones , Humans , Korea , Lung Diseases , Mycobacterium avium Complex , Mycobacterium avium , Mycobacterium , Tertiary Care Centers , Treatment Failure , Treatment Outcome
15.
Rev. Assoc. Med. Bras. (1992) ; 65(11): 1391-1396, Nov. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057081

ABSTRACT

SUMMARY BACKGROUND: Cardiac resynchronization therapy (CRT) is a therapeutic modality for patients with heart failure (HF). The effectiveness of this treatment for event reduction is based on clinical trials where the population of patients with Chagas' disease (DC) is underrepresented. OBJECTIVE: To evaluate the prognosis after CRT of a population in which CD is an endemic cause of HF. METHODS: A retrospective cohort conducted between January 2015 and December 2016 that included patients with HF and left ventricular ejection fraction (LVEF) of less than 35% and undergoing CRT. Clinical and demographic data were collected to search for predictors for the combined outcome of death or hospitalization for HF at one year after CRT implantation. RESULTS: Fifty-four patients were evaluated, and 13 (24.1%) presented CD as the etiology of HF. The mean LVEF was 26.2± 6.1%, and 36 (66.7%) patients presented functional class III or IV HF. After the mean follow-up of 15 (±6,9) months, 17 (32.1%) patients presented the combined outcome. In the univariate analysis, CD was associated with the combined event when compared to other etiologies of HF, 8 (47%) vs. 9 (13,5%), RR: 3,91 CI: 1,46-10,45, p=0,007, as well as lower values of LVEF. In the multivariate analysis, CD and LVEF remained independent risk factors for the combined outcome. CONCLUSION: In a population of HF patients undergoing CRT, CD was independently associated with mortality and hospitalization for HF.


RESUMO INTRODUÇÃO: A terapia de ressincronização cardíaca (TRC) é uma modalidade terapêutica para pacientes com insuficiência cardíaca (IC). A eficácia desse tratamento para redução de eventos baseia-se em ensaios clínicos em que a população de pacientes com doença de Chagas (DC) é sub-representada. OBJETIVO: Avaliar o prognóstico após TRC em uma população em que a DC é uma causa frequente de IC. MÉTODOS: Coorte retrospectiva realizada entre janeiro de 2015 e dezembro de 2016, sendo incluídos pacientes portadores de IC com fração de ejeção do ventrículo esquerdo (Feve) menor que 35% e submetidos à TRC. Os dados clínicos e demográficos foram coletados para pesquisa de preditores para o desfecho combinado de morte ou internação por IC após implante da TRC. RESULTADOS: Foram avaliados 54 pacientes, dos quais 13 (24,1%) apresentavam a DC como etiologia da IC. A Feve média foi de 26,2% (±6,1) e 36 (66,7%) pacientes apresentavam classe funcional de IC III ou IV. Após o seguimento médio de 15 meses, 17 (32,1%) pacientes apresentaram o desfecho combinado. Na análise univariada, a DC esteve associada ao evento combinado quando comparada a outras etiologias de IC, 8 (47%) vs 9 (13,5%), RR: 3,91 IC: 1,46-10,45, p=0,007, assim como valores mais baixos da Feve. Na análise multivariada, a DC e a Feve permaneceram como fatores de risco independentes para o desfecho combinado. CONCLUSÃO: Em uma população de pacientes com IC submetidos à TRC, a doença de Chagas esteve independentemente associada à mortalidade e internação por insuficiência cardíaca no seguimento de 15 meses.


Subject(s)
Humans , Male , Female , Aged , Chagas Cardiomyopathy/therapy , Cardiac Resynchronization Therapy , Heart Failure/therapy , Prognosis , Chagas Cardiomyopathy/complications , Chagas Cardiomyopathy/mortality , Retrospective Studies , Follow-Up Studies , Treatment Failure , Statistics, Nonparametric , Heart Failure/mortality , Heart Failure/parasitology , Middle Aged
16.
Ciênc. Saúde Colet ; 24(10): 3733-3742, Oct. 2019. tab
Article in Portuguese | LILACS | ID: biblio-1039486

ABSTRACT

Resumo O objetivo deste estudo foi investigar prevalências de falhas no diagnóstico, no uso de anti-hipertensivos e na eficácia do tratamento medicamentoso da hipertensão, e a associação destes parâmetros com variáveis sociodemográficas, de saúde e acesso ao serviço de saúde em idosos não institucionalizados. O estudo foi descritivo, transversal, com 3478 idosos, analisados separadamente em regiões Norte/Nordeste e Sul/Sudeste. Utilizou-se a regressão múltipla de Poisson para estimar razões de prevalência brutas e ajustadas pelo tipo de serviço de saúde utilizado. Do total, 29,6% dos idosos apresentaram falhas no diagnóstico, 4,6% no uso de anti-hipertensivos e 65,3% na eficácia medicamentosa. A falha no diagnóstico associou-se ao sexo masculino, menos morbidades, ter um companheiro, raça/cor branca, ter acesso ao convênio ou serviço privado de saúde, possuir renda pessoal inferior/média e ainda trabalhar. A falha no uso de anti-hipertensivos esteve associada à renda pessoal inferior/média e trabalhar. As falhas no manejo da hipertensão são prevalentes em idosos não institucionalizados. Há necessidade de ações que minimizem os impactos negativos destas insuficiências em saúde, em um país com diferenças sociais, econômicas e étnicas.


Abstract This study aimed to investigate the prevalence of failure in hypertension diagnosis, antihypertensive drug use and drug therapy efficacy and the association of these parameters with sociodemographic, health-related and access to health services variables in community-dwelling elderly. This is a descriptive cross-sectional study with 3,478 elderly from different Brazilian regions. We used Pearson's chi-square test to verify associations between outcomes and independent variables, and Poisson multiple regression to estimate crude and adjusted prevalence ratios. Of the total, 29.6% of the elderly evidenced failure in the diagnosis, 4.6% in the use of antihypertensives and 65.3% in drug efficacy. Diagnostic failure was associated with males, presence of morbidity, having a partner, white skin color/ethnicity, having access to the health covenant or private health service, with low/medium personal income and working. Antihypertensive use failure was associated with low/medium personal income and work. Hypertension management failures are prevalent in community-dwelling elderly. There is a need for actions that minimize the negative impact of these health shortcomings, in a country burdened by social, economic and ethnic differences.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Health Services Accessibility , Hypertension/drug therapy , Antihypertensive Agents/administration & dosage , Brazil , Sex Factors , Cross-Sectional Studies , Treatment Failure , Independent Living , Hypertension/diagnosis , Income
17.
J. bras. nefrol ; 41(3): 330-335, July-Sept. 2019. tab
Article in English | LILACS | ID: biblio-1040248

ABSTRACT

Abstract Introduction: Arteriovenous fistulas (AVF) are the best hemodialysis vascular accesses, but their failure rate remains high. Few studies have addressed the role of the vascular surgeon's skills and the facility's practices. We aimed to study these factors, with the hypothesis that the surgeon's skills and facility practices would have an important role in primary failure and patency rates at 12 months, respectively. Methods: This was a single-center, prospective cohort study carried out from March 2005 to March 2017. Only incident patients were included. A single surgeon made all AVFs, either in the forearm (lower) or the elbow (upper). Vascular access definitions were in accordance with the North American Vascular Access Consortium. Results: We studied 113 AVFs (65% lower) from 106 patients (39% diabetics, 58% started with catheter). Time to first connection was 21.5 days (IR: 14 - 31). Only 14 AVFs (12.4%) underwent primary failure and 18 failed during the first year. Functional primary patency rate was 80.9% (SE 4.1) whereas primary unassisted patency rate, which included PF, was 70.6% (4.4). Logistic regression showed that diabetes (OR = 3.3, 95%CI 1.38 - 7.88, p = .007) and forearm location (OR = 3.03, 95CI% 1.05 - 8.76, p = 0.04) were predictors of AVF failure. Patency of lower and upper AVFs was similar in non-diabetics, while patency in diabetics with lower AVFs was under 50%. (p = 0.003). Conclusions: Results suggest that a long-lasting, suitable AVF is feasible in almost all patients. The surgeon's skills and facility practices can have an important role in the long term outcome of AVF.


Resumo Introdução: Fístulas arteriovenosas (FAV) são os melhores acessos vasculares para hemodiálise, mas sua taxa de falhas permanece alta. Poucos estudos abordaram o papel das habilidades do cirurgião vascular e das práticas hospitalares. Nosso objetivo foi avaliar esses fatores, com a hipótese de que as habilidades do cirurgião e as práticas hospitalares teriam um papel importante nas taxas de falhas primárias e perviedade em 12 meses, respectivamente. Métodos: Este foi um estudo de coorte prospectivo de um único centro, realizado de março de 2005 a março de 2017. Apenas os pacientes incidentes foram incluídos. Um único cirurgião fez todas as FAVs, seja no antebraço (inferior) ou no cotovelo (superior). As definições de acesso vascular estavam de acordo com o Consórcio Norte-Americano de Acesso Vascular. Resultados: Estudamos 113 FAVs (65% inferiores) de 106 pacientes (39% diabéticos, 58% começaram com cateter). O tempo até a primeira conexão foi de 21,5 dias (RI: 14 - 31). Apenas 14 FAV (12,4%) tiveram falha primária e 18 falharam durante o primeiro ano. A taxa de patência funcional primária foi de 80,9% (SE 4,1), enquanto a taxa de permeabilidade primária não assistida, que incluiu FP, foi de 70,6% (4,4). A regressão logística mostrou que o diabetes (OR = 3,3, 95% IC 1,38 - 7,88, p = 0,007) e localização no antebraço (OR = 3,03, 95% IC 1,05 - 8,76, p = 0,04) foram preditores de falha da FAV. A patência das FAVs inferior e superior foi semelhante em não-diabéticos, enquanto a perviedade em diabéticos com FAV inferior foi menor que 50%. (p = 0,003). Conclusões: Nossos resultados sugerem que uma FAV duradoura e adequada é viável em quase todos os pacientes. As habilidades do cirurgião e das práticas hospitalares podem ter um papel importante no resultado a longo prazo da FAV.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Vascular Patency , Arteriovenous Shunt, Surgical , Clinical Competence , Surgeons , Health Facilities , Prospective Studies , Follow-Up Studies , Renal Dialysis/methods , Treatment Failure , Diabetes Mellitus , Elbow/surgery , Forearm/surgery , Kidney Failure, Chronic/therapy
18.
Rev. bras. cir. cardiovasc ; 34(4): 480-483, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1020495

ABSTRACT

Abstract The saphenous vein (SV) is the most commonly used conduit for coronary artery bypass surgery (CABG) and the second conduit of choice in Brazil and many other countries. The radial artery (RA) is suggested, by some, to be superior to SV grafts, although its use in the USA declined over a 10 year period. The patency of SV grafts (SVG) is improved when the vein is harvested with minimal trauma using the no-touch (NT) technique. This improved performance is due to the preservation of the outer pedicle surrounding the SV and reduction in vascular damage that occurs when using conventional techniques (CT) of harvesting. While the patency of NT SVGs has been shown superior to the RA at 36 months in one study, data from the RADIAL trial suggests the RA to be the superior conduit. When additional data using NT SVG is included in this trial the difference in risk of graft occlusion between the RA and SV grafts dissipates with there no longer being a significant difference in patency between conduits. The importance of preserving SV structure and the impact of NT harvesting on conduit choice for CABG patients are discussed in this short review.


Subject(s)
Humans , Saphenous Vein/transplantation , Coronary Artery Disease/surgery , Coronary Artery Bypass/methods , Radial Artery/transplantation , Vascular Patency , Brazil , Meta-Analysis as Topic , Treatment Failure
19.
Int. braz. j. urol ; 45(4): 790-797, July-Aug. 2019. tab
Article in English | LILACS | ID: biblio-1019876

ABSTRACT

ABSTRACT Objective The purpose of this study was to determine whether the presence of obesity was related with symptoms of nocturnal enuresis (NE) and the efficacy of behavioral intervention in the treatment of NE. Materials and Method The patients diagnosed with primary monosymptomatic nocturnal enuresis (PMNE) were studied retrospectively. NE severity was classified as mild, moderate, and severe according to the frequency of enuresis. The children were divided into three groups, namely normal weight (5th-84th percentile), overweight (85th-94th percentile), and obesity (≥95th percentile), according to their Body Mass Index (BMI) percentage. The relationship between obesity level and enuresis severity was analyzed. After three months of behavioral therapy, the efficacy of treatment among normal, overweight, and obese groups were evaluated. Moreover, the predictive risk factors for treatment failure were investigated. Results The rates of severe enuresis in patients with normal weight, overweight, and obesity were 63.9%, 77.5%, and 78.6%, respectively. Obese children depicted higher odds of having severe enuresis compared with normal-weight children (OR: 1.571; 95% confidence interval [CI]: 1.196-2.065; P=0.001). The odds of presenting with severe enuresis were 1.99 times higher in children who are obese or overweight compared to children with normal weight (OR: 1.994; 95% CI: 1.349-2.946; P=0.001). The complete response of the normal group was higher than those of the overweight and obese groups (26.8% vs. 14.0%, P=0.010; 26.8% vs. 0.0%, P=0.000). Overweight children showed higher complete response than obese ones (14.0% vs. 0.0%, P=0.009). Logistic regression analysis revealed that obesity level and enuresis frequency were significantly related to the treatment failure of behavioral intervention. Conclusions Obesity is associated with severe enuresis and low efficacy of behavioral therapy in children with nocturnal enuresis.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Behavior Therapy/methods , Nocturnal Enuresis/etiology , Nocturnal Enuresis/therapy , Pediatric Obesity/complications , Reference Values , Severity of Illness Index , Body Mass Index , Logistic Models , Sex Factors , Retrospective Studies , Risk Factors , Treatment Failure , Overweight/complications
20.
Rev. Asoc. Argent. Ortop. Traumatol ; 84(2): 105-111, jun. 2019.
Article in Spanish | LILACS, BINACIS | ID: biblio-1003018

ABSTRACT

Objetivo: Evaluar si la colocación de los dispositivos interespinosos siliconados tipo DIAM favorecen una tasa más alta de recidiva de la hernia discal homolateral clínica y por imágenes comparada con la discectomía pura. Materiales y Métodos: Se realizó un estudio prospectivo, observacional, aleatorizado desde mayo de 2009 hasta mayo de 2013, en nuestro Centro. Se evaluó a 123 pacientes, 3 se perdieron en el seguimiento; la muestra incluyó 120 sujetos. Todos fueron operados por el mismo equipo quirúrgico. Se formaron dos grupos: grupo A: discectomía más colocación de dispositivo interespinoso siliconado, 30 pacientes (16 mujeres y 14 hombres), con mayor frecuencia L4-L5 (27 pacientes, 90%) y grupo B: discectomías puras, 90 pacientes (53 mujeres y 37 hombres) con más frecuencia L4 y L5 (72 pacientes, 80%). Resultados: Seis de los pacientes del grupo A (20%) tuvieron una recidiva clínica y por imágenes, y 3 (10%) fueron operados nuevamente; en el grupo B, hubo 4 recidivas discales (4,4%), uno fue operado nuevamente (1,1%). Se hallaron diferencias significativas en las tasas de recidiva y reintervención entre los grupos (p = 0,0073 y p = 0,0188, respectivamente). Conclusiones: Los beneficios de los dispositivos interespinosos para tratar el canal estrecho lumbar secundario a hernia de disco son controvertidos, pero en nuestro estudio, se halló una diferencia significativa según el grupo. Al mantener el movimiento del segmento y cambiar ligeramente las cargas fisiológicas aumentarían la tasa de recidiva discal; no obstante, son necesarios estudios con mayor evidencia científica para corroborar estas tendencias. Nivel de Evidencia: III


Objective: The objective of this study was to determine if discectomy with placement of an interspinous DIAM silicon spacer is associated with a different rate of clinical and radiological recurrent ipsilateral disc herniation compared to discectomy alone. Methods: A prospective, observational, randomized study was performed from May 2009 to May 2013 at our center. Of the 123 patients included in the study, 3 were lost to follow-up, leaving 120 patients for data analysis. All patients were operated on by the same surgical team. Patients received one of two types of treatment. Group A consisted of 30 patients (16 women and 14 ment) who underwent discectomy with placement of an interspinous DIAM silicone spacer. Group B was comprised of 90 patients (53 women and 37 men) treated by discectomy alone. Results: Discectomy at L4-L5 level was the most common approach, being performed in 90% (27) of Group A patients and 80% (72) of Group B patients. Group A demonstrated clinical and radiological recurrent disc herniation in 6/30 (20%) patients. Recurrent disc herniation developed in 4/90 (4.4%) of Group B patients. One patient underwent surgical revision (1.1%). Both recurrence and surgical revision were significantly higher in Group A (p = 0.007 and p = 0.019, respectively). Conclusions: The benefits of interspinous devices for the treatment of the lumbar spinal stenosis secondary to disc herniation are controversial, and this study showed a significant intergroup difference. In this study, patients that underwent discectomy and interspinous spacer placement had higher revision and recurrence rates than discectomy patients that did not receive an interspinous spacer. Interspinous spacers may increase the rate of disc herniation by preserving movement at the level of the original disc herniation and changing the physiologic load. Further studies are needed to corroborate and evaluate these trends. Level of Evidence: III


Subject(s)
Adult , Middle Aged , Recurrence , Internal Fixators/adverse effects , Diskectomy , Intervertebral Disc Displacement/complications , Lumbar Vertebrae/surgery , Follow-Up Studies , Treatment Failure
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