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1.
Arq. gastroenterol ; 58(2): 139-144, Apr.-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1285330

ABSTRACT

ABSTRACT BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world, and its prevalence is increasing alongside obesity. In United States, NAFLD is already the second leading cause of liver transplantation. The spectrum of the disease ranges from simple steatosis, which has a benign course, to steatohepatitis, which may progress to cirrhosis and its complications. The rising of noninvasive methods for diagnosing and staging non-alcoholic steatohepatitis (NASH) and fibrosis decreases the need of liver biopsy, as well as the costs and the occurrence of complications related to it. OBJECTIVE: To analyze the performance of the triglyceride-glucose index to evaluate steatosis, NASH and liver fibrosis in obese patients with NAFLD. METHODS: This is a retrospective cross-sectional study. Every medical record of patients who were candidates for bariatric surgery at a leading hospital in Southern Brazil were analyzed. The triglyceride-glucose index (TyG Index), a method composed only of two simple laboratory tests (serum triglycerides and fasting glucose levels), was performed prior to surgery. The TyG Index performance regarding the anatomopathological findings was evaluated, and the AUROC curve was calculated to evaluate the best cut-off point for diagnosing steatosis, non-alcoholic steatohepatitis and liver fibrosis grade. Also, the NAFLD fibrosis Score (NFS) was evaluated. RESULTS: A total of 423 patients were evaluated. The TyG Index with a cut-off point of 8.76 excluded significant simple steatosis (grade 2-3) in obese patients, with 67.6% sensitivity, 65.1% specificity, 46.3% positive predictive value (PPV), 81.8% negative predictive value (NPV), 65.8% accuracy and 0.66 AUROC (P=0.005). In the evaluation of NASH, the TyG Index with a cut-off point of 8.82 excluded significant NASH (grade 2-3) with 57.3% sensitivity, 58.6% specificity, 33.7% PPV, 78.8% NPV, 58.2% accuracy and 0.58 AUROC (P=0.022). When evaluating liver fibrosis, the TyG Index with a cut-off point of 8.91 showed a sensitivity of 61.8%, a specificity of 62.5%, a PPV of 13.8 and a NPV of 94.4% for exclusion of advanced fibrosis (F3-4), with a 62.4% accuracy and 0.69 AUROC (P<0.001). When analyzing the performance of NFS in the diagnosis of advanced fibrosis, the cut-off point <-1.455 excluded advanced fibrosis with sensitivity of 59.4%, specificity of 51%, PPV of 11%, NPV of 92.4% and accuracy of 51.7%. However, the cut-off point of 0.676 to diagnose advanced fibrosis presented sensitivity of 21.9%, specificity of 83%, PPV of 11.7%, NPV of 91.2% and 77.3% accuracy. The AUROC was 0.54 (P=0.480). CONCLUSION: TyG Index did not perform well in the diagnosis of significant steatosis and NASH. However, it was able to exclude advanced fibrosis in obese patients who are candidates for bariatric surgery.


RESUMO CONTEXTO: A doença hepática gordurosa não-alcoólica (DHGNA) é a doença hepática mais prevalente no mundo. Nos Estados Unidos, a DHGNA já é a segunda causa de transplante hepático. O espectro da doença abrange desde a esteatose simples, que apresenta curso benigno, até esteato-hepatite não-alcoólica (EHNA), que pode progredir para cirrose e suas complicações. O desenvolvimento de métodos não invasivos para o diagnóstico e estadiamento da EHNA e da fibrose hepática visa diminuir a necessidade de biópsia hepática, um procedimento invasivo e não raro associado a complicações. OBJETIVO: Analisar o desempenho do índice triglicerídeo-glicose (TyG Index) para o diagnóstico e estadiamento da DHGNA em pacientes obesos. MÉTODOS: Este é um estudo transversal retrospectivo. Foram analisados todos os prontuários de pacientes candidatos a cirurgia bariátrica em um hospital de referência do Sul do Brasil e calculado o TyG Index, um escore composto por dois exames laboratoriais (triglicerídeos e glicose de jejum), realizados previamente à cirurgia. O desempenho do TyG Index em relação aos achados anatomopatológicos hepáticos foi avaliado, e calculada a curva ROC para avaliação de esteatose simples, EHNA e fibrose hepática. O NAFLD Fibrosis Score (NFS) também foi avaliado. RESULTADOS: Foram avaliados 423 pacientes. O melhor ponto de corte do TyG Index para a exclusão de esteatose simples significativa (grau 2-3) foi de 8,76, com sensibilidade 67,6%, especificidade 65,1%, valor preditivo positivo (VPP) 46,3%, valor preditivo negativo (VPN) 81,8%, acurácia 65,8% e AUROC 0,66 (P=0,005). Na avaliação de EHNA significativa (grau 2-3), o melhor ponto de corte foi de 8,82 com sensibilidade 57,3%, especificidade 58,6%, VPP 33,7%, VPN 78,8%, acurácia 58,8% e AUROC 0,58 (P=0,022). Em relação à fibrose avançada (grau 3-4), o melhor ponto de corte do TyG Index foi de 8,91 com sensibilidade 61,8%, especificidade 62,5%, VPP 13,8%, VPN 94,4%, acurácia 62,4% e AUROC 0,69 (P<0,001). Ao analisarmos o desempenho do NFS no diagnóstico de fibrose avançada, o ponto de corte de <-1,455 excluiu fibrose avançada com sensibilidade 59,4%, especificidade 51%, VPP 11%, VPN 92,4% e acurácia 51,7%. Entretanto, o ponto de corte de 0,676 para fibrose avançada apresentou sensibilidade de 21,9%, especificidade 83%, VPP 11,7%, VPN 91,2% e acurácia 77,3%. A AUROC foi de 0,54 (P=0,480). CONCLUSÃO: O TyG Index não apresentou bom desempenho para o diagnóstico e estadiamento da esteatose simples e da EHNA. Entretanto, foi capaz de excluir fibrose avançada em pacientes obesos candidatos a cirurgia bariátrica.


Subject(s)
Humans , Non-alcoholic Fatty Liver Disease/complications , Non-alcoholic Fatty Liver Disease/pathology , Triglycerides , Biopsy , Cross-Sectional Studies , Retrospective Studies , Glucose , Liver/pathology , Liver Cirrhosis/pathology , Obesity
2.
Av. enferm ; 39(2): 207-214, 01 may 2021.
Article in Spanish | LILACS, BDENF, COLNAL | ID: biblio-1290994

ABSTRACT

Objetivo: estimar el riesgo de prediabetes según los factores que presentan los participantes de un programa de ejercicio físico de la provincia de Chota, Perú. Metodología: estudio observacional, transversal y retrospectivo, desarrollado con 112 participantes pertenecientes a un programa de ejercicio físico. Se utilizó una guía de interpretación para analizar los factores de riesgo y la prediabetes en los participantes, la cual fue adaptada de una asociación norteamericana y dos instituciones de salud peruanas. Las pruebas estadísticas utilizadas fueron el odds ratio de prevalencia (ORP), la fracción etiológica poblacional (FEP) y el chi cuadrado de independencia. Resultados: el sedentarismo (ORP = 3,62), el exceso de triglicéridos (TGC) (ORP = 2,26) y el sobrepeso (ORP = 2,22) fueron los factores de riesgo identificados en los participantes. Según la FEP, si se interviene de manera adecuada y oportuna sobre estos factores, disminuiría la frecuencia de prediabetes en 8,57, 15,24 y 21,40 %, respectivamente. Conclusiones: los factores de riesgo de prediabetes en los usuarios estudiados fueron el sedentarismo, el exceso de TGC y el sobrepeso, resaltando al sedentarismo como el de mayor implicancia. Estos factores de riesgo, que reportaron una relación estadísticamente significativa con la prediabetes, pueden ser controlados y modificados. Por lo tanto, las intervenciones preventivas y promocionales en el primer nivel de atención deben fortalecerse y efectuarse mediante un trabajo integral y sostenible, con la finalidad de disminuir las cifras de prediabetes y condiciones conexas.


Objetivo: estimar o risco de prédiabetes de acordo com os fatores apresentados pelos participantes de um programa de exercícios físicos na província de Chota, Peru. Metodologia: estudo observacional, transversal, retrospectivo, desenvolvido com 112 participantes pertencentes a um programa de exercícios físicos. Um guia de interpretação foi utilizado para analisar os fatores de risco e o pré-diabetes nos participantes, o guia foi adaptado de uma associação norteamericana e duas instituições de saúde peruanas. Os testes estatísticos utilizados foram a razão de chances (odds ratio) de prevalência (ORP), a fração etiológica populacional (FEP) e o qui-quadrado de independência. Resultados: sedentarismo (ORP = 3,62), excesso de triglicerídeos (TGC) (ORP = 2,26) e sobrepeso (ORP = 2,22) foram os fatores de risco identificados nos participantes. De acordo com o FEP, se houver intervenção adequada e oportuna sobre esses fatores de risco a frequência de pré-diabetes diminuiria em 8,57 %, 15,24 % e 21,40 %, respectivamente. Conclusões: os fatores de risco para pré-diabetes nos usuários estudados foram sedentarismo, excesso de TGC e sobrepeso, destacando-se o sedentarismo como o de maior implicação. Esses fatores de risco que obtiveram relação estatisticamente significativa com o pré-diabetes podem ser controlados e modificados; portanto, as intervenções preventivas promocionais no primeiro nível de atenção devem ser fortalecidas e realizadas por meio de um trabalho abrangente e sustentável, a fim de reduzir o número de pré-diabetes e doenças relacionadas.


Objective: To estimate the risk of prediabetes in the participants of a physical exercise program in the province of Chota, Peru. Methodology: Observational, cross-sectional and retrospective study, developed with 112 participants in a physical exercise program. An interpretation guide was used to examine risk factors and prediabetes in the participants. This guide was adapted from a North American association and two Peruvian health institutions. The statistical tests used were the prevalence odds ratio (ORP), the population etiological fraction (PEF), and the chi square of independence. Results: A sedentary lifestyle (ORP = 3.62), the excess of triglycerides (TGC) (ORP = 2.26), and overweight (ORP = 2.22) were the main risk factors identified in participants. According to the FEP, if adequate and timely intervention is made over such factors, the frequency of prediabetes would decrease by 8.57, 15.24 and 21.40, respectively. Conclusions: Prediabetes risk factors in the studied population were a sedentary lifestyle, excess of TGC and overweight, highlighting sedentary lifestyle as that with the greatest effects on health. The identified risk factors, which reported a statistically significant relationship with prediabetes, can be controlled and modified. Therefore, promotional and preventive interventions at the first level of health care must be strengthened and carried out through comprehensive and sustainable work, in order to reduce the figures of prediabetes and its related conditions.


Subject(s)
Humans , Prediabetic State , Triglycerides , Exercise , Risk Factors , Overweight
3.
Arq. ciências saúde UNIPAR ; 25(1): 43-51, jan-abr. 2021.
Article in Portuguese | LILACS | ID: biblio-1151409

ABSTRACT

Introdução: Usuários do sistema de saúde com doenças crônicas não transmissíveis devem estar em acompanhamento constante para evitar complicações em seu estado de saúde. Objetivo: Analisar os indicadores laboratoriais de saúde em usuários de uma Unidade Básica de Saúde com e sem o diagnóstico para a diabetes e hipertensão. Métodos: A amostra foi de 231 usuários de uma unidade básica de saúde da cidade de Santarém-PA, maiores de idade, que foram agrupados em pacientes com DM/HAS (DM/HAS; n=144), e sem o diagnóstico para DM/HAS (AUS; n=87). As coletas envolveram informações socioeconômicas, clínicas e laboratoriais. Os dados foram tratados com estatística descritiva e inferencial, adotando-se p<0.05. Resultados: Tanto no DM/HAS como no AUS predominou o sexo feminino, estado civil casado, com vínculo empregatício, cor de pele parda, com 4-7 anos de estudo, renda de 1-2 salários, não tabagistas, não etilista e faixa etária de 38-77 anos. A HAS foi a doença mais presente de forma geral, bem como por sexo. Identificou-se no DM/HAS valores menores para a taxa de filtração glomerular (TFG) e maiores valores para a glicemia, triglicerídeos, colesterol total, LDL-c e não HDL-c. Conclusão: De acordo com a proposta desenvolvida, destaca-se que os usuários com DM/HAS apresentam associação positiva para valores alterados de glicemia, colesterol total, não HDL-c, triglicerídeos, TFG e para a presença da síndrome metabólica e risco cardiovascular moderado/alto.


Introduction: Users of the health system with chronic non-communicable diseases must be constantly monitored to avoid complications in their health status. Objective: Analyze laboratory health indicators in users of a Basic Health Unit with and without a diagnosis for diabetes and hypertension. Methods: The sample consisted of 231 users of a basic health unit in the city of Santarém-PA, all of them of age, grouped into patients with DM/SAH (DM/SAH; n=144), and without the diagnosis for DM/SAH (ABS; n=87). The collections involved socioeconomic, clinical, and laboratory information. The data were treated with descriptive and inferential statistics, adopting p <0.05. Results: In both DM/SAH and ABS groups, there was a predominance of female individuals, married status, employed, brown skin color, with 4-7 years of study, income of 1-2 salaries, non-smokers, non-alcoholic drinkers, and aged between 38-77 years. SAH was the most common disease in general, as well as when analyzing by gender. Lower values for the glomerular filtration rate (GFR) were identified in the DM/SAH and higher values for the glycemia, triglycerides, total cholesterol, LDL-c, and non-HDL-c. Conclusion: According to the proposal of this paper, it is noteworthy that users with DM/SAH have a positive association for altered values of blood glucose, total cholesterol, non-HDL-c, triglycerides, GFR, and for the presence of metabolic syndrome and moderate/high cardiovascular risk.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Health Evaluation/statistics & numerical data , Health Centers , Health Status Indicators , Tobacco Use Disorder/complications , Triglycerides/blood , Blood Glucose , Alcohol Drinking/adverse effects , Cardiovascular Diseases/diagnosis , Cholesterol/blood , Chronic Disease/nursing , Metabolic Syndrome/diagnosis , Diabetes Mellitus/diagnosis , Noncommunicable Diseases/prevention & control , Glomerular Filtration Rate , Hypertension/diagnosis , Cholesterol, HDL , Cholesterol, LDL/blood
4.
Article in Chinese | WPRIM | ID: wpr-879094

ABSTRACT

This article aims to investigate the ameliorative effect of Linderae Radix ethanol extract on hyperlipidemia rats induced by high-fat diet and to explore its possible mechanism from the perspective of reverse cholesterol transport(RCT). SD rats were divided into normal group, model group, atorvastatin group, Linderae Radix ethanol extract(LREE) of high, medium, low dose groups. Except for the normal group, the other groups were fed with a high-fat diet to establish hyperlipidemia rat models; the normal group and the model group were given pure water, while each administration group was given corresponding drugs by gavage once a day for five weeks. Serum total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol(HDL-c), low density lipoprotein-cholesterol(LDL-c), alanine aminotransferase(ALT), and aspartate aminotransferase(AST) levels were measured by automatic blood biochemistry analyzer; the contents of TC, TG, total bile acid(TBA) in liver and TC and TBA in feces of rats were detected by enzyme colorimetry. HE staining was used to observe the liver tissue lesions; immunohistochemistry was used to detect the expression of ATP-binding cassette G8(ABCG8) in small intestine; Western blot and immunohistochemistry were used to detect the expression of peroxisome proliferator-activated receptor gamma/aerfa(PPARγ/α), liver X receptor-α(LXRα), ATP-binding cassette A1(ABCA1) pathway protein and scavenger receptor class B type Ⅰ(SR-BⅠ) in liver. The results showed that LREE could effectively reduce serum and liver TC, TG levels, serum LDL-c levels and AST activity, and increase HDL-c levels, but did not significant improve ALT activity and liver index; HE staining results showed that LREE could reduce liver lipid deposition and inflammatory cell infiltration. In addition, LREE also increased the contents of fecal TC and TBA, and up-regulated the protein expressions of ABCG8 in small intestine and PPARγ/α, SR-BⅠ, LXRα, and ABCA1 in liver. LREE served as a positive role on hyperlipidemia model rats induced by high-fat diet, which might be related to the regulation of RCT, the promotion of the conversion of cholesterol to the liver and bile acids, and the intestinal excretion of cholesterol and bile acids. RCT regulation might be a potential mechanism of LREE against hyperlipidemia.


Subject(s)
Animals , Biological Transport , Cholesterol/metabolism , Diet, High-Fat/adverse effects , Hyperlipidemias/metabolism , Liver/metabolism , Rats , Rats, Sprague-Dawley , Triglycerides/metabolism
5.
Article in Chinese | WPRIM | ID: wpr-878929

ABSTRACT

The aim of this paper was to study the improvement effect of ethanol extract from Citri Reticulatae Pericarpium(CRP) on triglyceride of hyperlipidemia model rats, and to explore the possible mechanism. SD rats were randomly divided into normal group, model group, positive control group, and high, medium and low-dose CRP ethanol extract groups, with 10 rats in each group. During the experiment, except for the normal group that was fed with distilled water and ordinary feed, rats in the other groups were given different concentrations of alcohol and fed with high-sugar and fat diets. All rats were given free diets. While being modeled, each group was administered with 0.01 mL·g~(-1) by gavage once a day for six weeks. Blood samples were collected after two weeks, four weeks and six weeks of drug treatment. After the completion of the experiment, blood, liver and adipose tissue were collected. Triglyceride(TG), alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP) in serum, TG in liver tissue and TG in fecal were detected. Free fatty acid(FFA) and triglyceride-related hydrolase, such as adipose tiglyceride lipase(ATGL), lipoprotein lipase(LPL), hepatic lipase(HL), hormone-sensitive triglyceride lipase(HSL) were detected by ELISA. The mRNA expressions of peroxisome proliferators-activated receptors(PPARγ), sterol regulatory element binding protein 1 c(SREBP-1 c) and farnesoid X receptor(FXR) were determined by RT-PCR. Compared with the model group, each administration group could reduce TG levels in serum and liver to varying degrees, reduce serum ALT, AST, ALP activities, significantly reduce free fatty acid content in serum, significantly increase triglyceride metabolism-related enzymes, including fat ATGL, LPL and liver HL content, and significantly reduced the content of fat HSL. According to the study of transcriptional regulation genes relating to triglyceride metabolism, extract from CRP could significantly increase the mRNA expressions of PPARγ and FXR. In conclusion, ethanol extract from CRP could ob-viously reduce the TG level of hyperlipidemia model rats, and might reduce plasma TG content by increasing PPARγ-LPL/ATGL and FXR-HL triglyceride hydrolysis pathways.


Subject(s)
Animals , Ethanol , Hyperlipidemias/genetics , Liver , Plant Extracts , Rats , Rats, Sprague-Dawley , Triglycerides
6.
Chinese Medical Journal ; (24): 1079-1086, 2021.
Article in English | WPRIM | ID: wpr-878133

ABSTRACT

BACKGROUND@#The association of lipids and cancer has varied greatly among different cancer types, lipid components and study populations. This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.@*METHODS@#In the "Endoscopic Screening for Esophageal Cancer in China" (ESECC) trial, serum samples were collected and tested for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol at the time of subject enrollment. Cases were defined as malignant esophageal lesions identified by baseline endoscopic examination or by follow-up to May 31, 2018. Controls were randomly selected using incidence density sampling in the same cohort. Conditional logistic models were applied to identify the association of serum lipids and the risk of malignant esophageal lesions. Effect modification was evaluated by testing interaction terms of the factor under assessment and these serum lipid indicators.@*RESULTS@#No consistent association between serum lipid levels and esophageal malignant lesions were found in a pooled analysis of 211 cases and 2101 controls. For individuals with a family history of esophageal cancer (EC), high TC, and LDL-C were associated with a significantly increased risk of having malignant lesions (odds ratio [OR]High vs. Low TC = 2.22, 95% confidence interval [CI]: 1.14-4.35; ORHigh vs. Low LDL-C = 1.93, 95% CI: 1.01-3.65). However, a negative association was observed in participants without an EC family history (ORHigh vs. Low TC = 0.69, 95% CI: 0.48-0.98, Pinteraction = 0.002; ORHigh vs. Low LDL-C = 0.50, 95% CI: 0.34-0.76, Pinteraction < 0.001).@*CONCLUSIONS@#In this study, we found that the association of serum lipids and malignant esophageal lesions might be modified by EC family history. The stratified analysis would be crucial for population-based studies investigating the association of serum lipids and cancer. The mechanism by which a family history of EC modifies this association warrants further investigation.


Subject(s)
Case-Control Studies , China , Cholesterol, HDL , Early Detection of Cancer , Esophageal Neoplasms/genetics , Humans , Lipids , Triglycerides
7.
Article in English | WPRIM | ID: wpr-879966

ABSTRACT

To investigate the postoperative serum triglyceride (TG) levels in predicting the risk of new-onset diabetes mellitus (NODM) in patients following allogeneic liver transplantation. One hundred and forty three patients undergoing allogeneic liver transplantation in Shanghai General Hospital from July 2007 to July 2014 were enrolled in this study. The NODM developed in 33 patients after liver transplantation. The curve of dynamic TG levels in the early period after liver transplantation was generated. Independent risk factors of NODM were determined by univariate and multivariant logistic regression analyses. The clinical value of TG in predicting NODM was analyzed by area under the ROC curve (AUC). Serum TG levels were gradually rising in the first week and then reached the plateau phase (stable TG, sTG) in patients after surgery. The sTG in NODM group were significantly higher than that in non-NODM group (=-2.31, <0.05). Glucocorticoid therapy (=4.054, <0.01), FK506 drug concentration in the first week after operation (=3.482, <0.05) and sTG (=3.156, <0.05) were independent risk factors of NODM. ROC curve analysis showed that the AUC of sTG in predicting NODM was 0.72. TG shows a gradual recovery process in the early period after liver transplantation, and the higher TG level in stable phase may significantly increase the risk of NODM in patients.


Subject(s)
China/epidemiology , Diabetes Mellitus/etiology , Humans , Liver Transplantation/adverse effects , Risk Factors , Tacrolimus/adverse effects , Triglycerides
8.
Rev. chil. endocrinol. diabetes ; 14(2): 65-73, 2021. tab, ilus
Article in Spanish | LILACS | ID: biblio-1283551

ABSTRACT

INTRODUCCIÓN: Las dislipidemias favorecen la formación precoz de placas ateroscleróticas, aumentando el riesgo de enfermedades cardiovasculares (ECVs). La Actividad Física (AF) es un factor protector de ECVs, por lo que el objetivo de este trabajo fue evaluar la asociación entre AF medida objetivamente y dislipidemias en población pediátrica. METODOLOGÍA: La AF fue evaluada en 159 niños (9-13 años) de la Región de La Araucanía a través de acelerometría (ActiGraph GT3X+). Por este medio se estimó el porcentaje de AF moderada a vigorosa (AFMV) y el de conducta sedentaria (CS). Sujetos con ≥60 min de AFMV se consideraron físicamente activos según recomendación de la Organización Mundial de la Salud (OMS). Individuos con %CS>75° percentil fueron considerados sedentarios. El perfil lipídico fue determinado usando métodos convencionales. Fueron calculados índices de aterogenicidad TG/cHDL e índice de aterogenicidad del plasma (IAP). RESULTADOS: 37,1% presentó dislipidemia, 8% hipercolesterolemia, 19,5% hipertrigliceridemia, 6,3% cLDL elevado y 25,2% cHDL disminuido. Solo un 9,4% fueron considerados físicamente activos de acuerdo a la recomendación de la OMS. En los sujetos físicamente activos no hubo caso de dislipidemias (p= 0,032) y tampoco bajos niveles de cHDL (p= 0,013). El %AFMV estaba reducido en sujetos con cHDL bajo y se correlacionó positivamente con HDL-c (r= 0,157, p=0,048). Además, el %AFMV se correlacionó con menores valores de TG/cHDL (r= -0,193, p=0,015) e IAP (r= -0,214, p=0,006). Si bien el comportamiento sedentario no estuvo asociado con riesgo de dislipidemias, el %CS se correlacionó positivamente con niveles de glucosa (r= 0,159, p=0,044) y HOMA-IR (r= 0,178, p=0,037) y negativamente con Quicki (r= -0,160, p=0,044). CONCLUSIONES: Los hallazgos sugieren que la AF se correlaciona a menor frecuencia de dislipidemias y la práctica de AFMV aumentaría los valores de HDL-c y reduciría los índices aterogénicos, por lo que promoverla puede significar disminuir el riesgo de ECVs en nuestra población. Además, la CS se relaciona con un aumento en valores de glucosa e índices de resistencia insulínica en escolares de la Región de La Araucanía.


Dyslipidemias cause early formation of atherosclerotic plaque, increasing the risk of cardiovascular diseases (CVD). Physical Activity (PA) is a protective factor against CVDs. The aim of this study is to evaluate the association between objectively measured PA with dyslipidemias in a pediatric population. METHOD: The PA was evaluated in 159 children (9-13 years old) from Región de La Araucanía using accelerometry (ActiGraph GT3X +). The percentage of moderate to vigorous PA (MVPA) and sedentary behavior (SB) were estimated. Subjects with ≥60 min of MVPA were considered physically active according to the recommendation of the World Health Organization (WHO). Individuals with %SB >75th percentile were sedentary. The lipid profile was determined using conventional methods. TG/HDL-C ratio and atherogenic index of plasma (AIP) were calculated. RESULTS: 37.1% presented dyslipidemia, 8% hypercholesterolemia, 19.5% hypertriglyceridemia, 6.3% elevated LDL-C and 25.2% decreased HDL-C. Only 9.4% were physically active according to the WHO recommendation. In physically active subjects where no cases of dyslipidemias (p =0.032) and no low HDL-C (p = 0.013). The %MVPA was reduced in subjects with low HDL-C and positively correlated with HDL-c (r = 0.157, p = 0.048). In addition, %MVPA was correlated with lower TG / HDL-C values (r = -0.193, p = 0.015) and AIP (r = -0.214, p = 0.006). SB was not associated with risk of dyslipidemia, % SB was positively correlated with glucose levels (r = 0.159, p = 0.044) and HOMA-IR (r = 0.178, p = 0.037) and negatively with Quicki (r = -0.160, p = 0.044). CONCLUSIONS: Our results suggested that PA is it correlates to a lower frequency of dyslipidemia and the practice of MVPA would increase HDL-c values and reduce atherogenic index, promoting it may been reducing the risk of CVDs in our population. In addition, the SB is related to an increase in glucose values and insulin resistance index in schoolchildren in Región de La Araucanía.


Subject(s)
Humans , Male , Female , Child , Adolescent , Cardiovascular Diseases/prevention & control , Exercise , Dyslipidemias/blood , Students , Triglycerides/blood , Body Weight , Insulin Resistance , Chile , Anthropometry , Nutritional Status , Cross-Sectional Studies , Education, Primary and Secondary , Atherosclerosis/blood , Sedentary Behavior , Accelerometry , Heart Disease Risk Factors , Homeostasis , Cholesterol, HDL/blood , Cholesterol, LDL/blood
9.
Rev. chil. endocrinol. diabetes ; 14(1): 7-13, 2021. tab, ilus
Article in Spanish | LILACS | ID: biblio-1146465

ABSTRACT

INTRODUCCIÓN: La enfermedad del hígado graso no alcohólico (EHGNA) es la forma más común de enfermedad hepática. A nivel celular se caracteriza por la acumulación de triglicéridos (TG) en forma de gotas lipídicas (GL) dando lugar a esteatosis e inflamación. Entre los factores relevantes para la síntesis de TG se encuentran las enzimas DGAT1/2 que catalizan la etapa final de la síntesis de TG, y la proteína FABP4 que transporta lípidos intracelulares y se expresa en modelos de enfermedad hepática dependiente de obesidad. Por otra parte, TNF-α es una reconocida citoquina involucrada en el proceso inflamatorio en la EHGNA. La medicina popular del norte de Chile ha utilizado la planta Lampaya medicinalis Phil. (Verbenaceae) para el tratamiento de algunas enfermedades inflamatorias. OBJETIVO: Evaluar el efecto de un extracto hidroalcóholico de lampaya (EHL) sobre la esteatosis y expresión de marcadores de inflamación en hepatocitos tratados con ácidos grasos. Diseño experimental: Estudio in vitro en cultivos de la línea celular humana HepG2 tratadas con ácido oleico (AO) y ácido palmítico (AP). MÉTODOS: Se incubó hepatocitos HepG2 con AO/AP por 24 horas en presencia o no de EHL. Se evaluó la presencia de GL y el contenido de TG intracelulares por Oil Red O y Nile Red, respectivamente. La expresión de DGAT1/2, FABP4 y TNF-α fue evaluada por qPCR. RESULTADOS: Los hepatocitos tratados con AO/AP mostraron un aumento en las GL y TG, así como una mayor expresión de DGAT2 en comparación al control. El cotratamiento con EHL revirtió los efectos inducidos por AO/AP. CONCLUSIONES: EHL revierte el incremento en las GL, TG y en la expresión de DGAT2 inducido por AO/AP en células HepG2. Estos hallazgos sugieren un efecto hepatoprotector de la Lampaya contra la esteatosis, y apoyarían su uso complementario en el tratamiento de patologías con componente inflamatorio como la EHGNA.


Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. At the cellular level, it is characterized by the accumulation of triglycerides (TG) in the form of lipid droplets (LD), which leads to steatosis and inflammation. Among relevant factors for TG synthesis are the enzymes DGAT1/2 catalyzing the final stage of TG synthesis, and the protein FABP4 which transports intracellular lipids and is expressed in cell models of obesity-dependent liver disease. Additionally, TNF-α is a cytokine involved in the inflammatory process associated to NAFDL. Lampaya medicinalis Phil. (Verbenaceae) is a plant used in folk medicine in northern Chile to treat some inflammatory diseases. OBJECTIVE: To evaluate the effect of the hydroalcoholic extract of lampaya (HEL) on steatosis and the expression of inflammatory markers in hepatocytes treated with fatty acids. Study design: In vitro study in cultures of the human HepG2 cell line treated with oleic acid (OA) and palmitic acid (PA). METHODS: HepG2 hepatocytes were incubated with OA/PA for 24 hours in the presence and absence of HEL. The formation of LD and the accumulation of intracellular TG were assessed by Oil Red O and Nile Red, respectively. The expression of DGAT1/2, FABP4 and TNF-α was assessed by qPCR. RESULTS: The treatment with OA/PA increased the levels of LD and TG as well as the expression of DGAT2 in HepG2 hepatocytes compared to control cells. HEL cotreatment counteracted OA/PA-induced effects. CONCLUSIONS: HEL prevents the increase in LD and TG levels and DGAT2 expression induced by OA/PA in HepG2 cells. These findings suggest that lampaya may have a protective effect against hepatic steatosis, which would support its complementary use in the treatment of pathologies associated with inflammation, such as NAFLD.


Subject(s)
Humans , Plant Extracts/pharmacology , Hepatocytes/drug effects , Verbenaceae/chemistry , Non-alcoholic Fatty Liver Disease/drug therapy , Triglycerides/analysis , In Vitro Techniques , Plant Extracts/therapeutic use , Cell Survival , Polymerase Chain Reaction , Cell Culture Techniques , Oleic Acid , Ethanol/chemistry , Hep G2 Cells/drug effects , Inflammation
10.
Braz. j. med. biol. res ; 54(10): e11035, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285659

ABSTRACT

In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime.


Subject(s)
Humans , Cardiovascular Diseases/epidemiology , Climate , Lipids/blood , Lipoproteins/blood , Periodicity , Seasons , Triglycerides/blood , Brazil/epidemiology , Retrospective Studies , Cholesterol, HDL/blood
11.
Rev. Assoc. Med. Bras. (1992) ; 66(9): 1225-1228, Sept. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1136377

ABSTRACT

SUMMARY Polycystic ovary syndrome (PCOS) is an endocrinopathy with unknown pathophysiology among women of reproductive age. Several studies have been conducted to determine the prevalence of metabolic syndrome (MetS) among PCOS patients. Recent studies have reported varied prevalence of metabolic syndrome (MetS) in women with PCOS. The aim of this study is to determine if women with PCOS are at a higher risk of MetS or some degree of metabolic compromise. METHODS: This is an observational study. A total of 96 women diagnosed with PCOS (according to the Rotterdam consensus criteria) were included. Variables of diagnostic criteria for MetS according to the ATP III were analyzed at the first consultation. Data analysis was performed using Epi Info™ 7.2.2.16. RESULTS: We assessed the prevalence of obesity, blood pressure, glucose intolerance, and dyslipidemia in 96 women with PCOS and an average age of 28 (17-39) years. Forty percent of the women had BMI <25 kg/m2; 85.4% had blood pressure <130/85 mm Hg; 22.9% had HDL cholesterol >50 mg/dl, 57.3% had triglycerides <150 mg/dl, 63.5% had fasting glucose <100 mg/dl. According to the ATP III criteria for MetS, 8.33% met none of the criteria, 19.79% met one criterion, 15.63% two criteria, 41.67% 3 criteria, 13.54% 4 criteria, and 1.04% met the 5 criteria. CONCLUSION: Considering the high prevalence of MetS or altered metabolic components in PCOS patients at the moment of the diagnosis, its regular screening is necessary to reduce the mortality and morbidity rates in these women.


RESUMO A síndrome dos ovários policísticos (SOP) é uma endocrinopatia com fisiopatologia desconhecida em mulheres em idade reprodutiva. Vários estudos foram realizados para determinar a prevalência da síndrome metabólica (SM) em pacientes com SOP. Estudos recentes relataram prevalência variada de síndrome metabólica (SM) em mulheres com SOP. O objetivo deste estudo é determinar se as mulheres com SOP apresentam maior risco de SM ou algum grau de comprometimento metabólico. MÉTODOS: Estudo de desenho observacional. Foram incluídas 96 mulheres diagnosticadas com SOP (de acordo com os critérios de consenso de Roterdã). Variáveis de critérios de diagnóstico para SM de acordo com o ATP III foram analisadas na primeira consulta. A análise dos dados foi realizada usando o Epi Info™ 7.2.2.16. RESULTADOS: Avaliamos prevalência de obesidade, pressão arterial, intolerância à glicose e dislipidemia em 96 mulheres com SOP, com idade de 28 (17-39) anos. Quarenta por cento das mulheres tinham IMC <25 kg/m2; 85,4% tinham pressão arterial <130/85 mm Hg; 22,9% tinham colesterol HDL >50 mg/dl, 57,3% tinham triglicerídeos <150 mg/dl, 63,5% tinham glicemia de jejum <100 mg/dl. Segundo os critérios do ATP III para SM, 8,33% não possuíam critérios, 19,79% possuíam um critério, 15,63% possuíam dois critérios, 41,67% possuíam três critérios, 13,54% possuíam quatro critérios, 1,05% possuía os cinco critérios. CONCLUSÃO: Considerando a alta prevalência de SM ou algum componente metabólico alterado em pacientes com SOP no momento do diagnóstico, sua triagem regular é necessária para reduzir as taxas de mortalidade e morbidade nessas mulheres.


Subject(s)
Humans , Female , Adult , Polycystic Ovary Syndrome , Metabolic Syndrome , Triglycerides , Prevalence , Obesity
12.
Acta bioquím. clín. latinoam ; 54(3): 267-277, set. 2020. graf, tab
Article in Spanish | LILACS | ID: biblio-1130601

ABSTRACT

Diversos estudios evidencian la asociación entre los niveles elevados del colesterol de LDL (cLDL) y el riesgo de desarrollar enfermedad cardiovascular aterosclerótica. Con el objetivo de comparar los valores de cLDL obtenidos mediante la medición directa y los valores estimados por las ecuaciones de Friedewald tradicional, modificada y de regresión, se valoró el cLDL de 4.621 pacientes mediante el ensayo directo en el autoanalizador ADVIA 1800. Dichos resultados se agruparon en los estados de normolipemia, hipercolesterolemia, hiperlipemia mixta e hipertrigliceridemia y se establecieron diferencias de estimación con las mencionadas fórmulas en el total de la muestra y en los niveles de decisión clínica para el cLDL. Las tres fórmulas presentaron correlación significativa con el método directo en la totalidad de la muestra; sin embargo, cuando los niveles de triglicéridos de las muestras superaron los 200 mg/dL, la diferencia entre la fórmula de Friedewald y el método directo resultó -11,94%, y llegó a -19,13% para el nivel de triglicéridos mayor de 400 mg/dL. Por otro lado, las ecuaciones de Friedewald modificada y de regresión se vieron afectadas en menor cuantía por el nivel de triglicéridos. Las fórmulas de regresión y de Friedewald modificada se constituyen como alternativas razonables para estimar el cLDL y presentan buena concordancia con el método directo, incluso en niveles altos de colesterol y triglicéridos.


Several studies show the association between high LDL cholesterol (LDLc) levels and the risk of developing atherosclerotic cardiovascular disease. In order to compare the LDLc values obtained by direct measurement and the values estimated by the traditional, modified and regression Friedewald equations, the LDLc of 4,621 patients was assessed by means of the direct test in the ADVIA 1800 autoanalyzer.These results were grouped into the states of normolipemia, hypercholesterolemia, mixed hyperlipemia and hypertriglyceridemia, establishing differences in estimation with the aforementioned formulas in the total sample and in clinical decision levels for LDLc. The three formulas showed a significant correlation with the direct method in the entire sample; however, when the triglyceride levels of the samples exceeded 200 mg/dL, the difference between Friedewald's formula and the direct method was -11.94% reaching -19,13% for the triglyceride level greater than 400 mg/dL, while the modified Friedewald and regression equations were affected to a lesser extent by the triglyceride level. Regression and modified Friedewald formulas are constituted as reasonable alternatives to estimate LDLc and have good agreement with the direct method, even at high cholesterol and triglyceride levels.


Varios estudos evidenciam a associacao entre niveis elevados do colesterol LDL (cLDL) e o risco de desenvolver doenca cardiovascular aterosclerotica. Visando comparar os valores de cLDL obtidos atraves da medicao direta e os valores estimados pelas equacoes de Friedewald tradicional, modificada e de regressao, o cLDL de 4.621 pacientes foi avaliado por meio do teste direto no analisador automatico ADVIA 1800. Tais resultados foram agrupados nos estados de normolipemia, hipercolesterolemia, hiperlipemia mista e hipertrigliceridemia, estabelecendo-se diferencas na estimativa com as formulas mencionadas no total da amostra e nos niveis de decisao clinica para cLDL. As tres formulas apresentaram correlacao significativa com o metodo direto em toda a amostra, no entanto, quando os niveis de triglicerideos das amostras excederam 200 mg/dL, a diferenca entre a formula de Friedewald e o metodo direto foi de -11,94% atingindo -19,13% para o nivel de triglicerideos superior a 400 mg/dL. Por outra parte, as equacoes de Friedewald modificada e de regressao foram afetadas em menor grau pelo nivel de triglicerideos. As formulas de regressao e de Friedewald modificada se constituem como alternativas razoaveis para estimar o cLDL, e apresentam boa concordancia com o metodo direto, mesmo em niveis elevados de colesterol e triglicerideos.


Subject(s)
Triglycerides , Hypertriglyceridemia , Cholesterol , Hypercholesterolemia , Hyperlipidemias , Hyperlipoproteinemia Type V , Cholesterol, LDL , Cholesterol, LDL/blood , Patients , Association , Cardiovascular Diseases , Disease , Risk , Minors , Methods
13.
Acta bioquím. clín. latinoam ; 54(3): 257-266, set. 2020. graf, tab
Article in Spanish | LILACS | ID: biblio-1130600

ABSTRACT

EL HOMA-IR (homeostasis model assessment-insulin-resistance) es un estimador de insulinorresistencia (IR) pero depende de la determinación de insulina. Los índices triglicéridos-glucosa (T-G)-circunferencia de la cintura (CC) (T-G-CC) o triglicéridos-glucosa-índice de masa corporal (TG- IMC) podrían ser sustitutos. Los objetivos de este trabajo consistieron en investigar en personas con riesgo de desarrollar diabetes tipo 2 (DT2): a) los índices T-G, T-G-CC y T-G-IMC como estimadores de HOMA-IR>2,1; b) determinar su poder discriminante. Se realizó un estudio prospectivo en el que se estudiaron 223 individuos ≥45 años con riesgo de desarrollar diabetes tipo 2 (DT2). La relación T-G se calculó como ln [triglicéridos (mg/dL) x glucemia (mg/dL)/2]. La relación T-G-CC y T-G-IMC fue el producto de T-G por CC o IMC. Se utilizó análisis de regresión logística y se calcularon las áreas bajo las curvas ROC (receiver operating characteristic curves) (ABC) para comparar las asociaciones de T-G, T-G-CC y T-G-IMC con HOMA-IR>2,1. Mediante análisis discriminante se evaluó la clasificación de los sujetos entre HOMA-IR>2,1 y HOMA-IR≤2,1. ABC, sensibilidad, especificidad, poder predictivo positivo y negativo para T-G-CC y T-G-IMC fueron mayores que para T-G, con los siguientes valores de corte: T-G=8,75, T-G-CC=821 y T-G-IMC=255. Los odds ratios (OR) para HOMA-IR>2,1, ajustados para confusores, fueron: T-G>8,75, OR: 4,85 (IC 95% 2,73-8,62); T-G-CC>821, OR: 10,41 (IC 95% 5,55-19,53); T-GIMC> 255, OR: 10,41 (IC 95% 5,55-19,53). Con el análisis discriminante T-G>8,75 clasificó correctamente 69,2% individuos con HOMA-IR≤2,1 y 68,3% con HOMA-IR>2,1; T-G-CC y T-G-IMC clasificaron 74,4% y 78,2% respectivamente (p<0,001 en todos los casos). Se concluyó que T-GCC> 821 y T-G-IMC>255 fueron mejores estimadores de HOMA-IR>2,1 que T-G>8,75. Estas son determinaciones simples y accesibles y podrían ser útiles en la práctica clínica y en estudios epidemiológicos.


HOMA-IR ((homeostasis model assessment-insulin-resistance) is a surrogate estimator of insulin resistance (IR) but it depends on insulin determination. Triglyceride-glucose-waist circumference (T-G-WC) or triglyceride-glucose-body mass index (BMI) (T-G-BMI) could be substitutes. The objectives of this work were: to investigate in people at risk of developing type 2 diabetes (T2D): a) T-G, T-G-CC and T-G-BMI as estimators of HOMA-IR>2.1 and b) to determine their discriminating power. A prospective study was conducted studying 223 individuals ≥45 years of age at risk of developing type 2 diabetes (T2D). The T-G ratio was calculated as ln [triglycerides (mg/dL) x glycemia (mg/dL)/2]. The T-G-CC and T-G-BMI ratio was the product of T-G by CC or BMI. Logistic regression analysis was used and the areas under the receiver operating characteristic curves (ROC) curves were calculated to compare the associations of T-G, T-G-CC and T-G-BMI with HOMA-IR>2.1. Using a discriminant analysis, the classification of the subjects between HOMA-IR>2.1 or HOMA-IR≤2.1 was evaluated. AUC, sensitivity, specificity, positive and negative predictive powers for T-G-CC and T-G-BMI were higher than for T-G, with the following cut-off values: TG=8.75, T-G-CC=821 and T-G-BMI=255. Odds ratios (OR) for HOMA-IR>2.1, adjusted for confounders, were: T-G>8.75, OR 4.85 (95% CI 2.73-8.62); T-G-CC>821, OR 10.41 (95% CI 5.55-19.53); T-G-BMI>255, OR 10.41 (95% CI 5.55-19.53). With the discriminant analysis T-G>8.75, 69.2% correctly classified with HOMA-IR≤2.1 and 68.3% with HOMA-IR>2.1; T-G-CC and T-G-BMI correctly classified 74.4% and 78.2% respectively (p <0.001 in all cases). It is concluded that T-G-CC>821 and T-G-BMI>255 were better estimators of HOMA-IR>2.1 than T-G>8.75. T-G-WC and T-G-BMI are simple and reliable determinations and could be useful in clinical practice and epidemiological studies.


O HOMA-IR (homeostasis model assessment-insulin-resistance) e um estimador de resistencia a insulina (RI), mas depende da determinacao da insulina. Triglicerideos-glicose (T-G), circunferencia da cintura (CC) (T-G-CC) ou triglicerideos-glicose-indice de massa corporal (T-G-IMC) poderiam ser substitutos. Os objetivos desse trabalho foram investigar em pessoas com risco de desenvolver diabetes tipo 2 (DT2): a) os indices T-G, T-G-CC e T-G-IMC como estimadores de HOMA-IR> 2,1; b) determinar seu poder discriminante. Um estudo prospectivo foi realizado em 223 pessoas ≥45 anos com risco de desenvolver diabetes tipo 2 (DT2). A razao T-G foi calculada como ln [triglicerideos (mg/dL) x glicemia (mg/dL)/2]. A razao T-G-CC e T-G-IMC foi o produto de T-G por CC ou IMC. A analise de regressao logistica foi utilizada e as areas sob as curvas ROC (receiver operating features) ABC foram calculadas para comparar as associacoes de T-G, T-G-CC e T-G-IMC com HOMA-IR>2.1. Por meio de analise discriminante, avaliou-se a classificacao dos sujeitos entre HOMA-IR>2,1 e HOMA-IR≤2,1. ABC, sensibilidade, especificidade, poder preditivo positivo e negativo para TG-CC e TG-IMC foram maiores que para TG, com os seguintes valores de corte: TG=8,75, TG-CC=821 e TG-IMC=255. Odds Ratios (OR) para HOMA-IR>2,1, ajustados para fatores de confusao, foram: TG>8,75, OR 4,85 (IC95% 2,73-8,62); T-G-CC>821, OR 10,41 (IC 95% 5,55-19,53); T-G-IMC>255, OR 10,41 (IC 95% 5,55-19,53). Com a analise discriminante T-G>8,75, 69,2% foram classificados corretamente com HOMA-IR≤2,1 e 68,3% com HOMA-IR>2,1; T-G-CC e T-G-IMC classificaram 74,4% e 78,2%, respectivamente (p<0,001 em todos os casos). Conclui-se que T-G-CC>821 e TG- IMC>255 foram melhores estimadores de HOMA-IR>2,1 que T-G>8,75. Elas sao determinacoes simples e acessiveis e poderiam ser uteis na pratica clinica e em estudos epidemiologicos.


Subject(s)
Humans , Triglycerides , Power, Psychological , Epidemiologic Studies , Logistic Models , Odds Ratio , Confounding Factors, Epidemiologic , ROC Curve , Sensitivity and Specificity , Classification , Area Under Curve , Courtship , Diabetes Mellitus, Type 2 , Diabetes Mellitus, Type 2/complications , Glucose , Goals , Insulin , Persons , Organization and Administration , Association , Blood Glucose , Insulin Resistance , Body Mass Index , Discriminant Analysis , Risk , Regression Analysis , Waist Circumference
14.
J. Hum. Growth Dev. (Impr.) ; 30(2): 197-208, May-Aug. 2020. ilus, tab
Article in English | LILACS, INDEXPSI | ID: biblio-1114928

ABSTRACT

BACKGROUNG: People with Down syndrome (DS) may present changes in the lipid profile. The objective of this research was to collect data from the literature on the lipid profile and the effect of exercise on this variable of people with DS. Five databases were searched (MedLine, Lilacs, EBSCO Host, Web of Science and PsycInfo) using terms related to the research objectives. At the end of the searches, 15 articles were included in the review. Five studies verified changes in the lipid profile and high incidence of dyslipidemias, with the most frequent changes being low HDL and elevated triglycerides. Two studies investigated the effect of intervention with exercise and counseling for health-friendly practices and found improvement mainly in HDL after the intervention period. Thus, the lipid profile should be investigated in people with DS and the practice of physical exercises can be used to control these variables


INTRODUÇÃO: Pessoas com síndrome de Down (SD) podem apresentar alterações no perfil lipídico. O objetivo desta pesquisa foi reunir dados da literatura sobre o perfil lipídico e o efeito do exercício sobre essa variável de pessoas com SD. Cinco bases de dados foram pesquisadas (MedLine, Lilacs, EBSCO Host, Web of Science e PsycInfo), utilizando termos relacionados aos objetivos da pesquisa. Ao final das buscas, 15 artigos foram incluídos na revisão. Cinco estudos verificaram alterações no perfil lipídico e incidência elevada de dislipidemias, sendo as alterações mais frequentes o baixo HDL e triglicérides elevados. Dois estudos investigaram o efeito de intervenção com exercícios físicos e com aconselhamento para práticas benéficas para saúde e verificaram melhora principalmente no HDL depois do período de intervenção. Assim, o perfil lipídico deve ser investigado em pessoas com SD e a prática de exercícios físicos pode ser utilizada para o controle destas variáveis


Subject(s)
Humans , Male , Female , Triglycerides , Exercise , Cholesterol , Down Syndrome , Dyslipidemias
15.
Medicina (B.Aires) ; 80(4): 348-358, ago. 2020. graf
Article in Spanish | LILACS | ID: biblio-1154828

ABSTRACT

Resumen La quilomicronemia familiar es una condición en que una mutación genética altera la capacidad de metabolizar los triglicéridos que viajan en las lipoproteínas, causando elevación extrema de triglicéridos plasmáticos y complicaciones asociadas. La complicación más frecuente es la pancreatitis, que puede llevar a falla multiorgánica o insuficiencia pancreática. La quilomicronemia familiar también afecta la calidad de vida, las relaciones sociales y el desarrollo profesional. El gen más frecuentemente afectado en la quilomicronemia familiar es el de lipoproteína lipasa-1 (LPL), enzima que hidroliza triglicéridos circulantes para su captación tisular. Mutaciones en genes (como APOC2, APOAV, LMF-1, GPIHBP-1) que codifican para proteínas que regulan la maduración, transporte o polimerización de lipoproteína lipasa-1, también pueden estar involucradas. Sin embargo, en cerca del 30% de los pacientes no se encuentra la variante causal. La quilomicronemia familiar debe sospecharse en casos de hipertrigliceridemia extrema, resistente al tratamiento convencional, o que se acompaña de xantomas eruptivos, lipemia retinalis o dolor abdominal. La disponibilidad de escalas de riesgo y pruebas genéticas deben promover la detección oportuna. La nutrición se basa en una dieta muy baja en grasa con adecuada suplencia de vitaminas liposolubles y ácidos grasos esenciales, además de evitar el consumo de alcohol. Si bien el tratamiento farmacológico incluye fibratos y ácidos grasos omega 3, el enfoque actual privilegia agentes biotecnológicos dirigidos a los defectos moleculares propios de la enfermedad. Ello incluye un oligonucleótido antisentido dirigido contra apoC-III (volanesorsen), un anticuerpo monoclonal contra la proteína similar a angiopoietina tipo 3 (evinacumab), y otros compuestos en desarrollo.


Abstract Familial chylomicronemia is a disease in which a genetic mutation affects the ability of the organism to metabolize triglycerides bound to lipoproteins, causing extremely high plasma triglycerides and associated consequences. The most frequent complication is acute pancreatitis, which may lead to multiorganic failure or pancreatic insufficiency. Familial chylomicronemia also exerts a profound negative impact on quality of life, social relationships and professional development. The gene most frequently affected is lipoprotein lipase-1 gene (LPL), the enzyme in charge of hydrolyzing circulating triglycerides for tissue uptake. Mutations in other genes regulating maturation, transport or polymerization (eg. APOC2, APOAV, LMF-1, GPIHBP-1) of lipoprotein lipase-1, may also be involved. However, in about 30% of patients the causal variant is not identified. Familial chylomicronemia should be suspected in patients with severe hypertriglyceridemia with poor response to conventional treatment, or accompanied by eruptive xanthomas, lipemia retinalis or abdominal pain. The availability of risk scores and genetic tests should facilitate its opportune detection and management. Nutritional therapy is based on a very-low-fat diet with adequate supply of lipid-soluble vitamins and essential fatty acids, plus avoidance of alcohol consumption. Current pharmacological treatment may include fibrates and omega-3 fatty acids but prioritizes biotechnological agents targeting the molecular disturbances of the disease. These include an antisense oligonucleotide against apoC-III (volanesorsen), a monoclonal antibody against angiopoietin-like protein-3 (evinacumab), and other agents currently in development.


Subject(s)
Humans , Hyperlipoproteinemia Type I , Quality of Life , Triglycerides , Acute Disease
16.
Int. j. morphol ; 38(3): 755-760, June 2020. tab, graf
Article in English | LILACS | ID: biblio-1098316

ABSTRACT

SUMMARY: The objective of this study was to describe the effects of monosodium glutamate on the collagen of the parotid gland in an obesity model. 18 newborn male Sprague Dawley rats were used (first control group; second group of MSG1: 4 mg/g of monosodium glutamate weight, 5 doses, and third group of MSG2: 4 mg/g of monosodium glutamate, 5 doses, maintained for 8 and 16 weeks respectively). The content and type of collagen were analyzed, in addition to the levels of cholesterol, glucose, triglycerides and uric acid. Monosodium glutamate produced an increase in the obesity rates of the MSG2 group, in addition to an increase in blood cholesterol, glucose and uric acid levels compared to the control group. Type III collagen in the MSG2 group showed a statistically significant increase. Monosodium glutamate induced obesity, in addition to an increase in type III collagen fibers.


RESUMEN: El objetivo de este estudio fue describir los efectos del glutamato monosódico sobre el colágeno de la glándula parótida en un modelo de obesidad. Se utilizaron 18 ratas Sprague Dawley machos recién nacidas (primer grupo control; segundo grupo MSG1: 4 mg/g de peso de glutamato monosódico, 5 dosis, y tercer grupo MSG2: 4 mg/g de glutamato monosódico, 5 dosis, mantenidas durante 8 y 16 semanas respectivamente). Se analizó el contenido y el tipo de colágeno, además de los niveles de colesterol, glucosa, triglicéridos y ácido úrico. El glutamato monosódico produjo un aumento en las tasas de obesidad del grupo MSG2, además de un aumento en los niveles de colesterol en sangre, glucosa y ácido úrico en comparación con el grupo control. El colágeno tipo III en el grupo MSG2 mostró un aumento estadísticamente significativo. La obesidad inducida por glutamato monosódico, además de un aumento en las fibras de colágeno tipo III.


Subject(s)
Animals , Male , Rats , Parotid Gland , Sodium Glutamate/toxicity , Collagen/drug effects , Obesity/chemically induced , Salivary Glands/drug effects , Triglycerides/blood , Uric Acid/blood , Blood Glucose/analysis , Body Weight/drug effects , Cholesterol/blood , Collagen/analysis , Rats, Sprague-Dawley , Disease Models, Animal , Animals, Newborn
17.
rev. cuid. (Bucaramanga. 2010) ; 11(2): e1079, 1 de Mayo de 2020.
Article in English | LILACS, BDENF, COLNAL | ID: biblio-1118307

ABSTRACT

Introduction: Overweight and obesity are pathologies that are increasing every day. This study was aimed to determine the relationship between anthropometric variables and lipid profiles in a sample of young university students, which leads to taking future prevention actions. Materials and Methods: A descriptive correlational study was conducted with a sample of 182 university students (88 women and 94 men), whose anthropometric variables and lipid profiles were evaluated. Data were analyzed using the SPSS Statistics 20 software. The sample distribution was analyzed using the Kolmogorov-Smirnov normality test. Results were expressed as mean ± standard deviation or percentage, as applicable. Significance was established under the Pearson's correlation coefficient with p ≤0.05 value. Partial correlations were used to evaluate the relationship between each of the anthropometric risk indices and lipid profile values. Results: 46.7% of the population were overweight classifies as low-risk for waist circumference (45.1%), finding that the body adiposity index was healthy for their age in 64.5% of the participants. As for lipid profile, normal values for triglycerides were found in 60.4% of the participants and optimal values for total cholesterol in 56%. Correlational analysis with a significance of p≤0.005 was positive for gender with anthropometric variables such as Body Mass Index and waist circumference. Discussion: Anthropometric characteristics are closely related to the lipid profile behavior, as shown in this study, and the different research studies conducted with university students. Conclusions: Anthropometric variables are positively related to the gender of university students, finding an association between total cholesterol and triglycerides, which indicates a health risk factor.


Introducción: El sobrepeso y la obesidad son patologías que se incrementan día a día. El objetivo de este estudio fue determinar la relación de los parámetros antropométricos con el perfil lipídico en una muestra de jóvenes universitarios, que permitiría acciones de prevención futura. Materiales y Métodos: Se realizó un estudio descriptivo y correlacional con una muestra de 182 jóvenes universitarios distribuidos en 88 mujeres y 94 hombres, a los que se les evaluó variables antropométricas y perfil lipídico. Resultados: El 46.7% de la población presentó sobrepeso con una clasificación de riesgo bajo (45,1%) para el perímetro de cintura y se encontró que el índice de adiposidad corporal fue saludable para su edad en 64,5%. Respecto al perfil lipídico, se encontraron valores normales para triglicéridos en el 60,4% de la población y valores óptimos de colesterol total en el 56%. El análisis correlacional con una significancia de p≤0,005 fue positivo para sexo con variables antropométricas como el Índice de Masa Corporal y perímetro de cintura. Discusión: Las características antropométricas están estrechamente relacionadas con el comportamiento del perfil lipídico, como lo muestra el presente estudio y las diferentes investigaciones realizadas con estudiantes universitarios. Conclusiones: Las variables antropométricas se relacionan positivamente con el género de los estudiantes universitarios, en las que se encontró una asociación con valores de colesterol total y triglicéridos lo que indica factor de riesgo en salud.


Objetivo: O sobrepeso e a obesidade são patologias que aumentam dia a dia. O objetivo deste estudo é determinar a relação dos parâmetros antropométricos com o perfil lipídico em uma amostra de universitários, o que permitiria futuras ações de prevenção. Materiais e Método: Estudo descritivo correlacional com uma amostra de 182 alunos universitários distribuídos em 88 mulheres e 94 homens, nos quais foram avaliados variáveis antropométricas e perfil lipídico. Resultados: O 46,7% da população estava com excesso de peso, com uma classificação de risco baixo (45,1%) para a circunferência da cintura, constatando que o índice de adiposidade corporal era saudável para a idade em 64,5%. Em relação ao perfil lipídico, valores normais de triglicerídeos foram encontrados em 60,4% da população e valores ótimos de colesterol total em 56%. A análise de correlação com significância de p≤0,005 foi positiva para sexo com variáveis antropométricas, como o Índice de Massa Corporal e a circunferência da cintura. Discussão: As características antropométricas estão intimamente relacionadas ao comportamento do perfil lipídico, como mostra o presente estudo e a diferentes pesquisas realizadas em estudantes universitários. Conclusões: As variáveis antropométricas estão positivamente relacionadas ao sexo de alunos universitários, encontrando uma associação com valores de colesterol total e triglicerídeos, e indicando um fator de risco para a saúde.


Subject(s)
Humans , Male , Female , Adolescent , Obesity , Triglycerides , Cholesterol
18.
Rev. bras. ciênc. mov ; 28(1): 102-115, jan.-mar., 2020. tab
Article in Portuguese | LILACS | ID: biblio-1102721

ABSTRACT

O objetivo do estudo é analisar os efeitos de um programa de intervenção interdisciplinar no perfil de risco cardiometabólico de adolescentes com diagnóstico de sobrepeso/ obesidade. Estudo de intervenção, realizado com adolescentes com excesso de peso, constituído por grupo controle e grupo intervenção, o qual participou de um programa interdisciplinar com duração de seis meses. O grupo experimental final é composto por 23 adolescentes (12 sexo feminino e 11 sexo masculino). No início do programa, quatro adolescentes apresentavam sobrepeso e 19 obesidade. O grupo controle é composto pelo mesmo número de sujeitos, uma vez que este foi composto pelos pares dos escolares do grupo experimental. A intervenção contou com sessões de exercícios físicos, em três dias da semana e orientações nutricionais e psicológicas, uma vez por semana. Uma avaliação foi realizada antes do inicio do programa e logo após seu término. As avaliações consistiram em variáveis antropométricas - índice de massa corporal, circunferência da cintura, razão cintura-estatura e razão cintura -quadril, avaliação da pressão arterial, da aptidão cardiorrespiratória e coleta sanguínea para avaliação do perfil lipídico. Para a comparação das variáveis no período pré e pós-intervenção foi utilizado o teste t para amostras pareadas, para as variáveis de distribuição normal e, para as variáveis não paramétricas, foi aplicado o t este de Wilcoxon, considerando o nível de significância de p<0,05. O programa de intervenção foi eficaz n a redução de todos os indicadores antropométricos, na melhora dos níveis de aptidão cardiorrespiratória e na redução dos níveis de colesterol LDL. Entretanto, não modificou de forma significativa o s níveis de pressão arterial e demais parâmetros do perfil lipídico (colesterol total, HDL e triglicerídeos)...(AU)


: The objective of the study is to analyze the effects of an interdisciplinary in terven tion program on the cardiometabolic risk profile of adolescents diagnosed as overweight / obese. Intervention study with overweight adolescents, consisting of a control group and an intervention group, which participated in an interdisciplinary program lasting six months. The final experimental group co nsists o f 23 adolescents (12 females and 11 males). At the beginning of the program, four adolescents were overweight and 19 were obese. The control group is composed of the number of subject s, sin ce it was composed by the pairs of students in the experimental group. The intervention coun ted o n sessio n s o f physical exercises, in three days of the week and nutritional and psychological orientations, once a week . An evaluation was carried out before the start of the program and soon after its completion. The evaluations consisted of anthropometric variable - body mass index, waist circumference, waist-to-waist ratio, and waist-to-hip ratio, arterial pressure, cardiorespiratory fitness evaluation and blood collection t o evaluate the lipid profile. For the comparison of the variables in the pre- and post-intervention period, t he t-test for paired samples was used for the variables of normal distribution and fo r th e n on-parametric variables the Wilcoxon test was used, considering the level of significance of p < 0.05. The intervention program was effective in reducing all anthropometric indicators, improving cardiorespiratory fitness levels and reducing LDL cholesterol levels. However, it did not significantly modify the blood pressure levels and other parameters of the lipid profile (total cholesterol, HDL and triglycerides)...(AU)


Subject(s)
Humans , Male , Female , Physical Education and Training , Students , Body Mass Index , Control Groups , Risk Factors , Adolescent , Overweight , Control , Obesity , Orientation , Triglycerides , Blood Pressure , Cholesterol , Risk , Reference Parameters , Waist Circumference , Arterial Pressure , Cardiorespiratory Fitness , Cholesterol, HDL
19.
Medisan ; 24(2)mar.-abr. 2020. tab
Article in Spanish | LILACS-Express | LILACS, CUMED | ID: biblio-1098391

ABSTRACT

Introducción: Las dislipidemias asociadas a la obesidad constituyen factores de riesgo de varias enfermedades especialmente del sistema cardiovascular. Objetivo: Determinar la prevalencia de dislipidemias en pacientes obesos. Métodos: Se realizó un estudio correlacional, retrospectivo y transversal de150 pacientes obesos, quienes acudieron a la consulta externa de la Clínica Medina del Hospital Básico de Guayaquil, desde el 2018 hasta el 2019. Las variables analizadas fueron edad, sexo, índice de masa corporal y resultados de laboratorio, tales como colesterol total, triglicéridos, colesterol LDL y dislipidemia mixta (colesterol HDL y VLDL). Resultados: En la serie predominaron el sexo masculino (62,6%), los pacientes con más de 65 años de edad (42,0 %), los niveles entre rango crítico y alto riesgo (66 pacientes); 16,0 % se clasificaron de alto riesgo con niveles de colesterol superior a 240 mg/dL. Mostraron resultados anormales en cuanto a los triglicéridos 62 afectados, en un rango mayor de 150 con niveles y limítrofe altos. Conclusiones: Se observó una correspondencia entre las dislipidemias y la obesidad, pues todos los pacientes presentaron algún tipo de alteración en los lípidos.


Introduction: Dyslipidemias associated to obesity constitute risk factors of several diseases specially from the cardiovascular system. Objective: To determine the prevalence of dyslipidemias in obese patients Methods: A correlational restrospective and cross-sectional study of 150 obese patients, who visited the outpatients department of Medina Clinic from Hospital Básico in Guayaquil, from 2018 to 2019. Variables used were age, sex, body mass index and laboratory results such as total cholesterol, triglycerids. LDL colesterol and mixed dyslipidemias (cholesterol HDL and VLDL). Results: In the serie, male sex (62.6 %), patients over 65 years (42.0 %), levels between critical and high risk (66 patients) prevailed, 16.0 % were classified as high risk patients with cholesterol level over 240 mg/dL. Sixty two patients showed subnormal results regarding triglycerids, in a rank higher than 150 with high limits and levels. Conclusions: A correspondance between dyslipidemias and obesity was observed, as all patients presented some type of change in lipids.


Subject(s)
Triglycerides , Cholesterol , Dyslipidemias , Lipoproteins, HDL , Lipoproteins, LDL , Obesity
20.
Arch. argent. pediatr ; 118(2): 132-135, abr. 2020. ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1100246

ABSTRACT

Introducción. El subdiagnóstico y subregistro de sobrepeso y obesidad en pediatría es muy frecuente. El uso de una historia clínica electrónica podría contribuir favorablemente. El objetivo fue conocer el porcentaje de registro de este problema por pediatras de cabecera y analizar si se asociaba con la realización de estudios complementarios.Métodos. Estudio de corte transversal. Se evaluó el registro del problema en pacientes pediátricos con sobrepeso y obesidad, y la presencia de resultados de glucemia, triglicéridos y colesterol de alta densidad en pacientes obesos.Resultados. Se analizaron 7471 pacientes con sobrepeso y obesidad; el registro adecuado del problema fue del 19 %. El 44 % de los obesos (n = 1957) tenía registro adecuado y el 32 %, resultados de laboratorio, con asociación significativa entre variables.Conclusiones. Los porcentajes de registro de sobrepeso y obesidad y realización de estudios complementarios fueron bajos. El registro del problema se asoció a mayor solicitud de estudios


Introduction. Under-diagnosis and under-recording of overweight and obesity in pediatrics is very common. Using an electronic medical record may be helpful. The objective was to establish the percentage of recording of this problem by primary care pediatricians and analyze if it was associated with the performance of ancillary tests.Methods. Cross-sectional study. The recording of this problem among overweight and obese pediatric patients and the presence of blood glucose, triglycerides, and high-density lipoprotein cholesterol results in obese patients were assessed.Results. A total of 7471 overweight and obese patients were included; this health problem was adequately recorded in only 19 %. Among all obese patients (n = 1957), 44 % had adequate recording of this health problem; 32 % had lab test results showing a significant association among outcome measures.Conclusions. The percentage of overweight and obesity recording and ancillary test performance was low. Recording was associated with a higher level of test ordering


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Medical Records Systems, Computerized/statistics & numerical data , Overweight/epidemiology , Electronic Health Records , Obesity/epidemiology , Triglycerides , Blood Glucose , Cross-Sectional Studies , Cholesterol, HDL
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