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Medwave ; 18(8)2018.
Article in English, Spanish | LILACS | ID: biblio-969320


INTRODUCCIÓN La suplementación habitual del hipotiroidismo se basa en la monoterapia con levotiroxina, sin embargo, algunos pacientes persisten con síntomas atribuibles al déficit de hormona tiroidea. Debido a esto se ha planteado que el uso de un tratamiento combinado con liotironina y levotiroxina otorgaría un mayor beneficio. MÉTODOS Realizamos una búsqueda en Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud, la cual es mantenida mediante el cribado de múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, analizamos los datos de los estudios primarios, realizamos un metanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. RESULTADOS Y CONCLUSIONES Identificamos tres revisiones sistemáticas que en conjunto incluyeron 12 estudios primarios, todos correspondientes a ensayos aleatorizados. Concluimos que la adición de liotironina al tratamiento del hipotiroidismo tiene un efecto mínimo o nulo sobre fatiga y calidad de vida. Probablemente tampoco mejora estado de ánimo, dolor ni función cognitiva, y no reduciría el peso corporal.

INTRODUCTION The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit. METHODS We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS We identified three systematic reviews including twelve primary studies overall, all of which were randomized trials. We concluded that the addition of liothyronine to the treatment of hypothyroidism has minimal or no effect on fatigue and quality of life. It probably does not improve mood, pain or function cognitive, and it would not reduce body weight.

Humans , Thyroxine/administration & dosage , Triiodothyronine/administration & dosage , Hypothyroidism/drug therapy , Quality of Life , Body Weight , Randomized Controlled Trials as Topic , Databases, Factual , Treatment Outcome , Drug Therapy, Combination
Einstein (Säo Paulo) ; 13(1): 72-78, Jan-Mar/2015. tab, graf
Article in English | LILACS | ID: lil-745871


Objective To study the effect of different doses of triiodothyronine on gene expression of the adipokines leptin and adiponectin, at different times, and to evaluate the difference in expression between the two adipokines in each group. Methods 3T3-L1 adipocytes were incubated with triiodothyronine at physiological dose (10nM) and supraphysiological doses (100nM or 1,000nM), or without triiodothyronine (control, C) for 0.5, 6, or 24 hours. Leptin and adiponectin mRNA was detected using real-time polymerase chain reaction (RT-PCR). One-way analyses of variance, Tukey’s test or Student’s t test, were used to analyze data, and significance level was set at 5%. Results Leptin levels decreased in the 1,000nM-dose group after 0.5 hour. Adiponectin levels dropped in the 10nM-dose group, but increased at the 100nM dose. After 6 hours, both genes were suppressed in all hormone concentrations. After 24 hours, leptin levels increased at 10, 100 and 1,000nM groups as compared to the control group; and adiponectin levels increased only in the 100nM group as compared to the control group. Conclusion These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin. Triiodothyronine stimulated or inhibited the expression of adipokines in adipocytes at different times and doses which may be useful to assist in the treatment of obesity, assuming that leptin is increased and adiponectin is decreased, in obesity cases. .

Objetivo Examinar o efeito de diferentes doses de triiodotironina sobre a expressão gênica das adipocinas leptina e adiponectina, em diferentes períodos de tempo, além de avaliar a diferença de expressão entre as duas adipocinas em cada grupo. Métodos Adipócitos 3T3-L1 foram incubados com triiodotironina nas doses fisiológica (10nM) e suprafisiológicas (100nM ou 1.000nM), ou na ausência de triiodotironina (controle, C) durante 0,5, 6 ou 24 horas. O mRNA das adipocinas foi analisado em tempo real, utilizando a reação em cadeia de polimerase. Para as análises dos dados, foi utilizada a análise de variância, complementada com o teste de Tukey, ou o teste t de Student com 5% de significância. Resultados Os níveis de leptina diminuíram no grupo com dose de 1.000nM em 0,5 hora. A adiponectina também diminuiu no grupo com dose de 10nM, porém se elevou com a dose de 100nM. Após 6 horas, ambos os genes foram suprimidos em todas concentrações de hormônio. Em 24 horas, os níveis de leptina foram elevados em 10, 100 e 1.000nM, em relação ao grupo controle. No que concerne à adiponectina, observou-se aumento apenas no grupo cuja dose foi de 100nM, em comparação ao controle. Conclusão Foram demonstradas ações rápidas da triiodotironina sobre a expressão da leptina e da adiponectina, iniciando em 0,5 hora na dose de 1.000nM, para a primeira, e na dose de 100nM, para a segunda. A triiodotironina estimulou ou inibiu a expressão de adipocinas em adipócitos em diferentes tempos e doses, o que pode auxiliar no tratamento da obesidade, levando em consideração que, nesta, a leptina está aumentada e adiponectina, diminuída. .

Animals , Mice , /drug effects , Adipocytes/drug effects , Adiponectin/genetics , Gene Expression/drug effects , Leptin/genetics , Triiodothyronine/pharmacology , Analysis of Variance , Adiponectin/analysis , Cells, Cultured , Cell Differentiation/drug effects , Leptin/analysis , Obesity/genetics , Real-Time Polymerase Chain Reaction , Reference Values , RNA, Messenger/analysis , RNA, Messenger/drug effects , Time Factors , Triiodothyronine/administration & dosage
Arq. bras. endocrinol. metab ; 57(5): 368-374, jul. 2013. ilus, graf, tab
Article in English | LILACS | ID: lil-680624


OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRα and TRβ, at different times. MATERIALS AND METHODS: 3T3-L1 adipocytes were incubated with T3 (physiological dose: F; supraphysiological doses: SI or SII), or without T3 (control, C) for 0.5, 1, 6, or 24h. TRα and TRβ mRNA was detected using real-time polymerase chain reaction. RESULTS: F increased TRβ mRNA levels at 0.5h. After 1h, TRα levels increased with F and SI and TRβ levels decreased with SII compared with C, F, and SI. After 6h, both genes were suppressed at all concentrations. In 24h, TRα and TRβ levels were similar to those of C group. CONCLUSIONS: T3 action with F began at 1h for TRα and at 0.5h for TRβ. These results suggest the importance of knowing the times and doses that activate T3 receptors in adipocytes.

OBJETIVO: Examinar o efeito de diferentes doses de triiodotironina (T3) sobre a expressão gênica dos receptores TRα e TRβ em diferentes tempos. MATERIAIS E MÉTODOS: Adipócitos, 3T3-L1, foram incubados com T3 nas doses fisiológica (F, 10nM) e suprafisiológicas (SI, 100nM ou SII, 1000nM) ou veículo (controle, C) durante 0,5, 1, 6 ou 24h. mRNA dos TRs foram detectados utilizando PCR em tempo real. RESULTADOS: Níveis de TRβ aumentaram em F em 0,5h. Após 1h, níveis de TRα aumentaram em F e SI comparado ao C, enquanto TRβ diminuiu no SII comparado com C, F, e SI. Após 6h, ambos os genes foram suprimidos em todas concentrações. Em 24h, níveis de TRα e TRβ retornaram aos do C. CONCLUSÕES: Ação do T3 em F iniciou-se em 1h para TRα e 0,5h para TRβ. Esses resultados são importantes para determinar tempo inicial e dose de T3 em que os receptores de HT são ativados em adipócitos.

Animals , Adipocytes/drug effects , Antigenic Modulation/immunology , Thyroid Hormone Receptors alpha/metabolism , Thyroid Hormone Receptors beta/metabolism , Triiodothyronine/administration & dosage , Adipocytes/metabolism , Cell Line , Drug Administration Schedule , RNA, Messenger/analysis , Thyroid Hormone Receptors alpha/genetics , Thyroid Hormone Receptors beta/genetics , Triiodothyronine/pharmacology
Indian J Exp Biol ; 2007 Dec; 45(12): 1015-21
Article in English | IMSEAR | ID: sea-58323


Gill is the main organ of osmotic regulation in teleosts and chloride cells are the sites of ion transport across gill epithelium. Thyroid hormones are implicated in the regulation of osmotic balance in teleosts also. Treatment with 6-propyl thiouracil (6-PTU) inhibited the membrane bound enzyme Na+K+ ATPase in the gill while triiodothyronine (T3) injection stimulated it in a short-term in vivo study in the teleost Anabas testudineus. Na+, K+ and Ca2+ ions were also decreased in the 6-PTU treated fish and the T3 treatment increased their concentrations in the gill lamellae. The gill morphology also changed according to the thyroid status in the long term study. 6-PTU treatment altered the typical serrated morphology of the gill lamellae, while the T3 treatment reversed it. T3 injection increased the density of pavement and chloride cells as evidenced by scanning electron microscopy. The results demonstrate that physiological status of the thyroid influences gill Na+ pump activity and chloride cell morphological changes. Further, the study suggests a regulatory role of T3 on gill ions (Na+, K+ and Ca2+), Na+K+ and Ca2+ ATPase activity and the different gill cell types in A. testudineus.

Animals , Calcium/metabolism , Calcium-Transporting ATPases/metabolism , Gills/cytology , Hypothyroidism/physiopathology , Longitudinal Studies , Microscopy, Electron, Scanning , Osmotic Pressure , Perciformes/physiology , Potassium/metabolism , Sodium/metabolism , Thyroid Hormones/administration & dosage , Triiodothyronine/administration & dosage
Rev. chil. cardiol ; 26(4): 437-443, 2007. ilus, tab
Article in Spanish | LILACS | ID: lil-499074


Introducción: El receptor scavenger clase B tipo I (SR-BI) es un elemento clave en el metabolismo de las HDL, donde su expresión ejerce un importante efecto anti-aterogénico controlando la fase hepática del transporte reverso de colesterol. Así, el estudio de la modulación de la expresión de SR-BI permitiría el desarrollo de nuevas alternativas farmacológicas para el tratamiento de la ateroesclerosis. Objetivo: La meta de nuestro estudio fue determinar el efecto de la triiodotironina (T3) y el glucagón sobre el metabolismo del colesterol HDL y la expresión hepática de SR-BI en el ratón, evaluando simultáneamente su impacto sobre el colesterol total y lipoproteico plasmático y la secreción biliar de colesterol. Métodos: Se utilizaron ratones C57BL/6 tratados con T3 (30 nmol/kg/día) o glucagón (80 µg/día) más los respectivos grupos controles. Después del tratamiento, los animales se anestesiaron para recolección de bilis, plasma y tejido hepático. Los niveles totales de colesterol plasmático y biliar fueron medidos por métodos enzimáticos. El colesterol lipoproteico plasmático se evaluó por fraccionamiento cromatográfico del plasma y medición enzimática del colesterol en cada fracción. La expresión hepática de SR-BI se cuantificó mediante western blot. Resultados: El uso de T3 o glucagón disminuyeron significativamente el colesterol plasmático total y aumentaron el colesterol biliar con respecto al grupo control correspondiente. Las fracciones de colesterol VLDL, LDL y HDL disminuyeron en ambos grupos tratados, con un mayor efecto observado en la fracción HDL. La administración de ambas hormonas aumentaron significativamente los niveles hepáticos de SR-BI. Conclusión: Los resultados establecen que T3 y glucagón disminuyen el colesterol plasmático, predominantemente de tipo HDL, y aumentan la secreción de colesterol biliar en el ratón, probablemente como consecuencia del incremento en la expresión hepática...

Introduction: The scavenger receptor class B type I (SR-BI) plays a key role in the metabolism of high-density lipoprotein (HDL) cholesterol. Its expression has an important anti-atherogenic effect by controlling the hepatic phase of the reverse cholesterol transport pathway in vivo. Thus, the study of the modulation of SR-BI expression may allow the development of new pharmacologic approaches for treatment of atherosclerotic cardiovascular disease. Objective: The goal of this study was to determine the effect of triiodothyronine (T3) and glucagon on HDL metabolism and hepatic expression of SR-BI in mice, evaluating also the impact in total and lipoprotein cholesterol as well as biliary cholesterol secretion. Methods: C57BL/6 mice were treated with T3 (30 nmol/kg/día) or glucagon (80 µg/día) in comparison to appropriate control groups. After treatment, bile, plasma and hepatic tissue were collected for analysis. Total plasma and biliary cholesterol levels were measured by enzymatic methods. Lipoprotein cholesterol was also measured enzymatically after chromatographic separation of plasma samples. The hepatic expression of SR-BI protein was quantified by western blotting. Results: The use of T3 or glucagon significantly decreased total plasma cholesterol levels and increased of biliary cholesterol concentrations compared to control groups. Levels of VLDL, LDL and HDL cholesterol were reduced in both treatment groups, with a more important effect observed in the HDL fraction. Both treatments increased hepatic SR-BI protein levels. Conclusions: These results show that T3 and glucagon decrease plasma cholesterol levels, particularly in HDL, and increase biliary cholesterol secretion in mice, probably as a consecuence of higher hepatic expression of SR-BI, which may have led to facilitated HDL cholesterol transport from plasma into bile.

Animals , Mice , Cholesterol, HDL/metabolism , Glucagon/pharmacology , Liver/metabolism , Scavenger Receptors, Class B , Triiodothyronine/pharmacology , Blotting, Western , Bile/chemistry , Cholesterol, HDL/analysis , Cholesterol/analysis , Fluorescent Antibody Technique , Glucagon/administration & dosage , Liver , Receptors, Lipoprotein , Triiodothyronine/administration & dosage
Braz. j. med. biol. res ; 39(7): 969-978, July 2006. tab, graf
Article in English | LILACS | ID: lil-431561


Treatment of non-thyroidal illness by intravenous triiodothyronine (T3) after cardiac surgery causes a disproportional elevation of hormone levels. The administration of oral T3, which has never been studied in this context, could cause physiological hormone levels. The aim of this study was to test oral T3 for the prevention of T3 reduction during the postoperative period of valvular cardiac surgery in adults. Eighteen patients who underwent cardiac surgery for valvular disease with invasive hemodynamic monitoring were randomly assigned to 2 groups: the T group received oral T3 (N = 8), 25 æg three times/day, initiated 24 h before surgery and maintained for 48 h and the NT group (N = 10) received placebo. Serum T3, thyroxine and thyrotropin were determined at baseline, 1 h before surgery, within 30 min of cardiopulmonary bypass and 6, 12, 24, and 48 h after removal of the aortic cross-clamp. Baseline T3 was similar in both groups (T: 119 ± 13; NT: 131 ± 9 ng/dL). Serum T3 increased during the first 24 h in the T group compared to the NT group (232 ± 18 vs 151 ± 13 ng/dL; P < 0.001). In the NT group, T3 was reduced by 24 percent (P = 0.007) 6 h after removal of the aortic cross-clamp, confirming the non-thyroidal illness syndrome. There were no differences in clinical or hemodynamic parameters between groups. Administration of oral T3 prevented its serum reduction after valvular cardiac surgery in adults, with normal serum levels for 48 h without disproportional elevations.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Cardiac Surgical Procedures , Euthyroid Sick Syndromes/prevention & control , Heart Valve Diseases/surgery , Triiodothyronine/administration & dosage , Case-Control Studies , Monitoring, Physiologic/methods
Indian J Exp Biol ; 2003 Aug; 41(8): 846-9
Article in English | IMSEAR | ID: sea-63021


The present study critically evaluates the effects of hypothyroid and hyperthyroid states on lipid peroxidation and two enzymes of active oxygen metabolism, namely superoxide dismutase (SOD) and catalase (CAT) in the rat heart mitochondrial and post-mitochondrial fractions. Lipid peroxidation, an index of oxidative stress, was elevated in the heart tissue in hypothyroid state but reduced upon T3 supplementation. Hyperthyroidism registered increased SOD activity in post-mitochondrial fraction. Mitochondrial SOD activity was reduced in hypothyroid state, which was further reduced by T3 administration. In contrast, different thyroid states had no effect on catalase activity in the mitochondrial fraction. The hypothyroid state however, significantly augmented catalase activity in post-mitochondrial fraction. The results suggest that the antioxidant defence status of cardiac tissue is well modulated by thyroid hormone.

Animals , Catalase/metabolism , Disease Models, Animal , Hyperthyroidism/blood , Hypothyroidism/blood , Lipid Peroxidation , Male , Mitochondria, Heart/enzymology , Myocardium/enzymology , Organ Size/physiology , Rats , Rats, Wistar , Superoxide Dismutase/metabolism , Thyroxine/blood , Triiodothyronine/administration & dosage , Uracil/analogs & derivatives
Arequipa; UNSA; jul. 1996. 40 p. ilus.
Thesis in Spanish | LILACS | ID: lil-192206


Se realizó un estudio para valorar los niveles séricos de Triyodotironina (T3) en pacientes con Tuberculosis Pulmonar severa con evolución adecuada e inadecuada a la quimioterapia específica (Isoniacida, Rifampicina, Etambutol, Pirazinamida) luego de 2 meses de administrada la misma. Para ello se estudiaron tres grupos : Grupo Control constituido por pacientes clinicamente sanos, Grupo 1 en el que se incluyeron pacientes con evolución adecuada al tratamiento y Grupo 2 donde se encontraban los pacientes con evolución inadecuada al tratamiento (clínica baciloscópia y radiológica). Todos estos sujetos estuvieron entre los 20 y 30 años de edad, siendo de ambos sexos. Los resultados objetivos nos muestran para el Grupo 1 niveles de triyodotironina de 1.44 ñ 0.26 ng/ml, para el Grupo 2 de 0.68 ñ 0.44 ng/ml. Los valores del grupo control fueron de 1.41 ñ 0.36 ng/ml. Se encontró una diferencia altamente significativa (p<0.001) entre los pacientes del Grupo 2 comparados con los del Grupo 1 y el Grupo Control, luego de aplicar las pruebas estadísticas de Análisis de Varianza y de Kruskall-Wallis. Por estos resultados podemos concluir que los niveles séricos de T3 podrían ser utilizados para el seguimiento de los pacientes con tuberculosis pulmonar y constituirse como un factor pronóstico objetivo en este tipo de pacientes.

Humans , Triiodothyronine/administration & dosage , Tuberculosis, Pulmonary , Pulmonary Medicine
Med. crít. venez ; 11(1): 10-5, ene.-abr. 1996. ilus
Article in Spanish | LILACS | ID: lil-192571


El síndrome del eutiroideo enfermo se caracteriza por alteraciones transitorias en las pruebas de funcionamiento tiroideo en pacientes con enfermedades sistémicas agudas y crónicas, críticamente enfermos, sometidos a intervenciones quirúrgicas con traumatismos físicos; describiéndose en estos pacientes varios síndromes de alteración de la función tiroidea: T3 baja, T3 y T4 baja, T4 elevada. Se realiza una revisión del síndrome del eutiroideo enfermo haciendo un especial énfasis en los aspectos relativos a la fisiopatología, a las alteraciones en el funcionalismo tiroideo y a las enfermedades sistémicas agudas y crónicas que se han relacionado con la presencia del síndrome.

Humans , Male , Female , Endocrinology/methods , Thyroid Diseases/pathology , Thyroid Diseases/surgery , Thyroid Hormones/physiology , Thyroxine/administration & dosage , Triiodothyronine/administration & dosage
Medicina (B.Aires) ; 56(3): 273-6, 1996. ilus, graf
Article in English | LILACS | ID: lil-181484


The L-Triiodothyronine (L-T3) has a direct influence on the population of somatotrophs in rat pituitary gland. This effect is dose-dependent and induces both proliferation of somatotrophs and striking changes in the synthesis and secretion of grwth hormone (GH). Daily injections of 5 mug L-T3 for 7 days increased significantly the synthesis and storage of GH in pituitary gland, but the GH release was partially blocked. By contrast, injections of 10 mug L-T3 promote rapid synthesis and secretion of GH with removal of the cytoplasmic stores of the hormone and a consequent rise of serum levels. A close correlation was found between levels of stimulation and proliferation or retrogression of lactotroph cell population.

Animals , Male , Rats , Pituitary Gland , Growth Hormone/drug effects , Triiodothyronine/pharmacology , Pituitary Gland/metabolism , Growth Hormone/biosynthesis , Growth Hormone/metabolism , Microscopy, Electron , Rats, Wistar , Triiodothyronine/administration & dosage
Gac. méd. Méx ; 131(2): 141-6, mar.-abr. 1995. ilus, tab
Article in Spanish | LILACS | ID: lil-174034


Los niños con hipotiroidismo congénito se hallan en riesgo de fallecer en forma inesperada. Con el propósito de probar esta hipótesis, se estudiaron las causas de muerte y las enfermedades concomitantes en 16 necropsias de casos con hipotiroidismo congénito. Cuatro pacientes con atireosis fallecieron sin diagnóstico ni tratamiento. El resto fueron diagnosticados tardíamente(después de los dos meses de edad), por exhibir niveles bajos de T3 y T4. Nueve casos de la serie fallecieron inesperadamente, tres en el hospital y seis en su domicilio. Los hallazgos de la necropsia sugieren broncoaspiración en cinco casos y falla cardíaca en cuatro. Los siete casos restantes fallecieron por complicaciones de índole infecciosa. Se concluye que en el hipotiroidismo congénito diagnosticado y tratado tardíamente, existen trastornos orgánicos sistémicos, que asociados al daño neurológico pueden provocar la muerte. Una atención particular a la función cardíaca y a los trastornos en la deglución, podrían detectar los casos de alto riesgo

Infant , Child, Preschool , Humans , Male , Female , Anemia/physiopathology , Attributable Risk , Autopsy , Cause of Death , Thyroid Gland/abnormalities , Hypothyroidism/congenital , Hypothyroidism/mortality , Heart Failure/physiopathology , Thyroid Hormones/therapeutic use , Thyroxine/administration & dosage , Triiodothyronine/administration & dosage
Article in English | LILACS | ID: lil-161097


Para contribuir a clarificar el rol de las hormonas tiroideas en la modulación de la eritropoyesis y profundizar en el conocimiento de los efectos de estas hormonas en la anemia de la insuficiencia renal crónica (CRF), estudiamos "in vitro" la acción de la l-triiodotironina (LT) y DT3, un isómero dextrorotatorio no-calorigénico de la T3 sobre precursores eritroides comprometidos maduros (CFU-E) y primitivos (BFU-E) de la médula ósea de ratas normales anémicas. Los cultivos fueron preparados usando la técnica de la metilcelulosa conteniendo una dosis standard de eritropoyetina (Ep) (182 mU/ml), LT3 y DT3 en dosis de o.5, y 1.5 ug/ml. Las hormonas tiroideas fueron agregadas a los cultivos en ausensia de Ep. Nuestros resultados demuestram que LT3 y DT3 producen una estimulación significativa y directa sobre la formación de CFU-E y un moderado incremento de BFU-E. Hubo una aparente relación dosis-dependiente en los cultivos que contienen las hormonas tiroideas. La DT3 fue menos activa que la LT3. Como se esperaba, la Ep produjo un significativo incremento en la formación de colonias eritroides, principalmente CFU-E. Los efectos de LT3, DT3 y Ep sobre el desarrollo de las colonias eritroides fue significativamente mayor en cultivos celulares de médula ósea de ratas anémicas con CRF, indicando la existencia de una cinética celular proliferativa más elevada en los progenitores eritroides comprometidos en respuesta a estas drogas.

Animals , Male , Rats , Erythroid Precursor Cells , Erythropoiesis/drug effects , Renal Insufficiency, Chronic/drug therapy , Triiodothyronine/pharmacology , Anemia/complications , Hypothyroidism/complications , Renal Insufficiency, Chronic/etiology , Bone Marrow/cytology , Triiodothyronine/administration & dosage
Rev. Col. Bras. Cir ; 18(4): 115-9, jul.-ago. 1991. tab
Article in Portuguese | LILACS | ID: lil-108449


Os autores estudaram, prospectivamente, 41 casos de paci-entes submetidos a laringectomias ou faringolaringectomias com o objetivo deavaliar os efeitos do uso da triiodotironina na incidencia de complicaçoes lo- cais pos-operatorias. Os casos foram divididos de forma randomizada em 22 pacientes para o grupo-controle e 19 pacientes para o grupo experimental. Os dois gru-pos foram avaliados quanto a idade,estadiamento da lesao, tipo de cirurgia e exames pre-operatorios; tendo sido considerados comparaveis. As complicaçoes locaisforam avaliadas de forma qualitativa em necrose, infecçao e fistula; e de forma quantitativa em uma escala de uma a tres cruzes conforme a magnitude do processoDos pacientes do grupo-controle, 15(68%) tiveram algum tipo de complicaçao localcontra apenas 6 (32%) pacientes do grupo experimental. Alem disso, houve diferença favoravel ao grupo ewxperimental em relaçao a intensidade dos processos. Con-clui-se que a administraçao pos-operatoria de triiodotironina reduz pela metadea incidencia e diminui a intensidade das complicaçoes locais pos-operatorias em pacientes submetidos a laringectomias e faringolaringectomias

Laryngectomy , Pharyngectomy , Triiodothyronine/administration & dosage , Hypothyroidism , Triiodothyronine/therapeutic use
Medicina (B.Aires) ; 51(4): 331-4, 1991. tab
Article in Spanish | LILACS | ID: lil-108067


El presente trabajo estudió el efecto del frío sobre el consumo del oxígeno (CO) y la actividad *-glicerofosfato deshidrogenasa (*-GPD) en mitocondria cardíaca de ratas hipotiroideas (hipo) tratadas con T3, T4 o T4 más Acido lopanoico (IOP). Se usaron ratas Wistar macho de 200g de peso hechas hipotiroideas con la administración de I. Los animales fueron inyectadoss s.c., en dosis divididas, por 10 días, con una de las siguientes sustancias: T3, 300 ng/100g peso/día; T4, 2 *g/100g peso/día o T4 más IOP, 5 mg/100g peso/día, por 72 hs. previas al experimento. Una mitad de cada grupo fue mantenida a 4§C y el resto a 22§C, por 24 hs., y logo decapitados. Se aislaron las mitocondrias de corazón por métodos de rutina. El CO se midió polarográficamente usando L-malato, L-glutamato y malonato como sustratos. La actividad mitocondrial *-GPD se medió por un método microcolorimétrico. Los resultados correspondientes a 16 o 20 ratas/grupo (4 o 5 "pooles" de 4 corazones cada uno) fueron los isguientes: En las ratas mantenidas a 22§C el CO (en ng at. de oxíg./min/mg prot.; Estado 3) de las Hipo+T4 fue de 69 ñ 10; en el grupo tratado con T4+IOP fue de 75 ñ 11 y ...

Rats , Animals , Male , Cold Temperature , Oxygen Consumption/physiology , Glycerolphosphate Dehydrogenase/metabolism , Mitochondria, Heart/physiology , Adaptation, Physiological , Body Temperature Regulation , Thyroid Hormones/therapeutic use , Hypothyroidism/drug therapy , Hypothyroidism/physiopathology , Rats, Inbred Strains , Triiodothyronine/administration & dosage
Rev. Fac. Cienc. Méd. (Córdoba) ; 48(1/2): 7-12, 1990. ilus
Article in Spanish | LILACS | ID: lil-105398


La gónada de Bufo arenarum se presenta con características femenminas en todas las larvas dado que esta especie representa un ejemplo de raza sexual "indiferenciada". El sexo genético masculino recién se evidencia luego de la metamorfosis. A fin de comprobar la eventual vinculación entre diferenciación gonadal y hormona tiroidea, se trataron las larvas con tri-iodo-tironina. Los resultados demuestran un incremento en el número y en el grado de maduración de los ovocitos

Animals , Gonads/embryology , Sex Differentiation/drug effects , Triiodothyronine/pharmacology , Bufo arenarum , Gonads/pathology , Metamorphosis, Biological/drug effects , Triiodothyronine/administration & dosage