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1.
J. bras. nefrol ; 36(4): 535-541, Oct-Dec/2014. tab
Article in Portuguese | LILACS | ID: lil-731148

ABSTRACT

A doença renal crônica (DRC) é caracterizada por uma perda progressiva da função renal e suas principais causas são hipertensão arterial (HA) e diabete melito. Entre as causas de HA, podemos destacar a doença renal aterosclerótica (DRA). O desenvolvimento de DRC nos pacientes com DRA parece ser decorrente não apenas do acometimento das artérias renais principais, mas também da microcirculação renal, o que pode justificar o fato de o sucesso do procedimento não garantir uma melhora da evolução da DRC. Até o presente momento, não existe evidência de benefício da angioplastia em relação ao tratamento clínico exclusivo nos pacientes com DRA. O presente trabalho analisa os estudos mais significantes sobre os desfechos renais em pacientes portadores de DRA submetidos à revascularização ou ao tratamento clínico exclusivo.


Chronic kidney disease (CKD) is characterized by a progressive loss of renal function and its main causes are hypertension and diabetes mellitus. Among the causes of hypertension is atherosclerotic renal disease (ARD). The development of CKD in patients with ARD appears to be due not only to the involvement of the main renal arteries, but also of the renal microcirculation, which may explain the fact that the success of the procedure does not guarantee an improvement in the progression of CKD. To date there is no evidence of benefit of angioplasty compared to medical treatment alone in patients with ARD. The present paper analyzes the most significant studies on renal outcomes in patients with ARD undergoing revascularization or medical treatment alone.


Subject(s)
Animals , Female , Humans , Mice , Antineoplastic Agents/pharmacology , Antineoplastic Combined Chemotherapy Protocols/pharmacology , Breast Neoplasms/drug therapy , Oxidoreductases/antagonists & inhibitors , Paclitaxel/administration & dosage , Pyrimidines/pharmacology , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/pathology , Dihydrouracil Dehydrogenase (NADP) , Floxuridine/administration & dosage , Floxuridine/pharmacology , Mice, Inbred ICR , Neoplasm Transplantation , Tegafur/administration & dosage , Tegafur/pharmacology , Uracil/administration & dosage , Uracil/pharmacology
2.
Salud pública Méx ; 56(5): 519-527, sep.-oct. 2014. ilus, tab
Article in Spanish | LILACS | ID: lil-733325

ABSTRACT

Objetivo. Explorar las necesidades de información y consejería de un grupo de mujeres mexicanas al utilizar la prueba de virus de papiloma humano (VPH). Material y métodos. En 2011, se realizaron 24 entrevistas semiestructuradas a mujeres que recibieron el resultado de una prueba de VPH, en dos municipios del estado de Michoacán. El análisis cualitativo de las entrevistas se realizó con las técnicas de la comparación constante. Resultados. Durante el tamizaje, las mujeres recibieron escasa consejería; experimentaron angustia y confusión. Las usuarias de la prueba se mostraron interesadas en recibir información sobre el VPH y el cáncer cervical, el significado de sus resultados, los pasos que habrían de realizar en la atención, apoyo emocional e información vinculada con la transmisión sexual de VPH. Conclusiones. Se requiere diseñar e implementar políticas para impartir educación para la salud y consejería, a la par de la realización de pruebas de VPH.


Objective. To explore the information and counseling needs of a group of Mexican women during use of the HPV test. Materials and methods. In 2011, 24 semistructured interviews were done with women upon receiving HPV test results in two municipalities in the state of Michoacan. Qualitative analysis of the interviews was done using constant comparison techniques. Results. During their use of screening services women received limited counseling; they felt anguish and confusion. Women were interested in receiving information and advice on HPV and cervical cancer, the meaning of test result, next steps to be taken in their healthcare use as well as information and emotional support related to the sexual transmission of HPV. Conclusions. The design and implementation of policies are needed which instigate health education and counseling in conjunction with HPV testing.


Subject(s)
Animals , Mice , Antineoplastic Agents/toxicity , Enzyme Inhibitors/pharmacology , Floxuridine/toxicity , Intestines/drug effects , Thymidine Phosphorylase/antagonists & inhibitors , Uracil/analogs & derivatives , Administration, Oral , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/therapeutic use , Body Weight , Carcinoma, Lewis Lung/drug therapy , Drug Synergism , Floxuridine/administration & dosage , Floxuridine/therapeutic use , Isomerism , Uracil/administration & dosage , Uracil/pharmacology
3.
Indian J Exp Biol ; 2000 Sep; 38(9): 931-5
Article in English | IMSEAR | ID: sea-61184

ABSTRACT

Carbamoyl phosphate synthetase (CPS) activity in Streptomyces lividans was repressed (70%) by addition of arginine and uracil in the growth medium. Enzyme activity was also inhibited by UMP and activated by ornithine and IMP. Pattern of inhibition and activation was similar irrespective of whether the cells were grown in medium supplemented with arginine or with uracil. A mutant of S. coelicolor with dual auxotrophy for arginine and uracil possessed only about 20% of CPS activity compared to the wild-type strain. An activity staining protocol has been developed for CPS enzyme. Using this method a single CPS band has been observed in the crude extracts of Escherichia coli as well as in S. lividans. Taken together, our results supported the conclusion that Streptomyces species might possess a single CPS enzyme unlike other gram-positive bacteria, which show the presence of two pathway-specific isozymes (Bacillus) or none (Lactobacillus and Leuconostoc).


Subject(s)
Allosteric Regulation , Arginine/pharmacology , Carbamyl Phosphate/metabolism , Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/genetics , Colorimetry , Escherichia coli , Gene Expression Regulation, Bacterial , Glutamine/metabolism , Magnesium , Mutation , Radiometry , Streptomyces/drug effects , Uracil/pharmacology
4.
Rev. argent. microbiol ; 22(1): 1-6, 1990. ilus
Article in Spanish | LILACS | ID: lil-95046

ABSTRACT

Se estudió el efecto de la privación de triptofano y uracilo sobre la viabilidad del tansformante Bacillus subtilis BSA trp ura y de las cepas parentales Bacillus subtilis PB 168 trp-C y Bacillus subtilis PB 3308 ura. Los ensayos se llevaron a cabo en las condiciones descriptas para el desarrollo de competencia para transformación, durante 16 h. Los resultados obtenidos demostraron que Bacillus subtilis BSA 170 trp ura es resistente a la muerte por carencia de triptofano durante el tiempo del ensayo y a la muerte por carencia de uracilo durante 3h. Luego ocurre una disminución de la recuperación de UFC, acompañada por una reduccción de las absorbancias de los cultivos. La muerte por carencia de uracilo es prevenida en ausencia de triptofano, sugiriendo que reuiere síntesis de proteínas. Las cepas parentales mostraron un comportamiento semejante. Bacillus subtilis PB 168 trp-C mostró ser resistente a la muerte por carencia de triptofano y Bacillus subtilis PB 3308 uta sufrió una reducción de la capacidad para formar colonias, debida a la privación de uracilo, comparable a la de la cepa transformante


Subject(s)
Bacillus subtilis/metabolism , Bacillus subtilis/drug effects , Bacillus subtilis/genetics , Bacterial Proteins/biosynthesis , Tryptophan/pharmacology , Uracil/pharmacology
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