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1.
Braz. j. biol ; 84: e255529, 2024. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1364534

ABSTRACT

Reports from popular medicine usually act as a basis for the development of new drugs from natural compounds with therapeutic actions for serious diseases and prevalence such as cancer. Bromelia antiacantha Bertol. is a species of the Bromeliaceae family, considered an unconventional food plant, found in the south and midwest regions of Brazil. Despite the high nutritional content and pharmacological potential of its fruits, few scientific studies report its biological actions. Thus, this study evaluates the phytochemical profile of aqueous and ethanol extracts obtained from B. antiacantha fruits, as well as their possible antioxidant, antitumor, and cytotoxic activities. The aqueous extract exhibited phenolic compounds and flavonoids, while ethanol extracts indicated the presence of flavonoids and coumarin in their composition, regardless of the region of collection. The ethanolic extract demonstrated a more promising antioxidant effect than the aqueous extract and also induced a significant inhibition in the viability of human cervical cancer cells of the SiHa strain. In addition, treatment with both extracts did not alter the viability of non-tumor cells of the immortalized human keratinocyte lineage (HaCaT). These results bring new data about extracts obtained from a native plant, edible and traditionally used in popular medicine, opening new perspectives for its possible therapeutic application.


Relatos da medicina popular costumam atuar como referencial para o desenvolvimento de novos fármacos a partir de moléculas naturais com ações terapêuticas para doenças de alta gravidade e prevalência como o câncer. Bromelia antiacantha Bertol. é uma espécie da família Bromeliaceae, considerada uma planta alimentícia não convencional (PANC), encontrada nas regiões sul e centro-oeste do Brasil. Apesar do alto teor nutritivo e potencial farmacológico de seus frutos, poucos estudos científicos relatam suas ações biológicas. Desta forma, este estudo avalia o perfil fitoquímico de extratos aquoso e etanólico obtidos de frutos de B. antiacantha, bem como a sua possível ação antioxidante, antitumoral e citotóxica. O extrato aquoso apresentou compostos fenólicos e flavonoides, enquanto os extratos etanólicos apontam a presença de flavonóides e cumarina em sua composição, independente da região de coleta. O extrato etanólico demonstrou efeito antioxidante mais promissor do que o extrato aquoso e também induziu uma inibição significativa na viabilidade de células humanas de câncer cervical da linhagem SiHa. Além disso, o tratamento com ambos extratos não alterou a viabilidade de células não tumorais da linhagem de queratinócitos humanos imortalizados (HaCaT). Estes dados trazem novas informações sobre extratos obtidos de uma espécie vegetal nativa, comestível e já utilizada tradicionalmente, mas abrindo novas perspectivas quanto a possíveis aplicações terapêuticas.


Subject(s)
Flavonoids , Uterine Cervical Neoplasms , Bromeliaceae , Bromelia , Therapeutic Uses , Phytochemicals , Phytotherapy
2.
Esc. Anna Nery Rev. Enferm ; 27: e20220198, 2023. tab
Article in Spanish | LILACS, BDENF | ID: biblio-1404746

ABSTRACT

Resumen Objetivo analizar las experiencias de enfermeras en la toma de las citologías cervicales y otros factores organizacionales durante una intervención educativa asistida por metodologías B-learning. Método estudio cualitativo realizado en San Luis Potosí, México. Participaron 15 enfermeras. La recolección de datos se hizo a través de entrevistas semiestructuradas con base en una sistematización de experiencias. Para el análisis de la información se utilizó el programa Taguette y como referente teórico las metodologías B-learning. Resultados se identificaron debilidades en factores relacionados con la accesibilidad de las usuarias al servicio, insumos, infraestructura, bioseguridad, capacitación del personal de salud, entrega de resultados a las pacientes y conocimiento del programa por parte de las usuarias. Conclusiones e implicaciones para la práctica el cáncer cervical es un problema de salud pública. La citología cervical es la prueba de tamizaje más utilizada; sin embargo, existen limitantes en la calidad, por lo que se proponen acciones para mejorar los conocimientos y habilidades del personal de enfermería que tiene como función la toma. La intervención educativa fue efectiva para fomentar el aprendizaje integral sobre la toma de las citologías cervicales y permitió al personal de enfermería compartir sus experiencias.


Resumo Objetivo analisar as experiências das enfermeiras na realização de esfregaços cervicais e outros fatores organizacionais durante uma intervenção educacional assistida por metodologias de b-learning. Método estudo qualitativo realizado em San Luis Potosí, México. Participaram 15 enfermeiras. A coleta de dados foi feita por meio de entrevistas semiestruturadas a partir de uma sistematização de experiências. Para a análise das informações, utilizou-se o programa Taguette e metodologias de b-learning como referencial teórico. Resultados foram identificadas fragilidades em fatores relacionados com a acessibilidade dos usuários ao serviço, insumos, infraestrutura, biossegurança, capacitação da equipe de saúde, entrega de resultados aos pacientes e conhecimento do programa pelos usuários. Conclusões e implicações para a prática o câncer do colo do útero é um problema de saúde pública. A citologia cervical é o teste de triagem mais utilizado; no entanto, existem limitações na qualidade, por isso são propostas ações para aprimorar os conhecimentos e habilidades das enfermeiras que estejam desempenhando essa função. A intervenção educacional foi eficaz para promover o aprendizado integral sobre a realização do esfregaço cervical e permitiu que as enfermeiras compartilhassem suas experiências.


Abstract Objective to analyze the nursing staff's experiences in taking cervical smears and other organizational factors during an educational intervention assisted by B-learning methodologies. Method a qualitative study was carried out in San Luis Potosí, Mexico, with 15 nurses. Data collection was done through semi-structured interviews based on a systematization of experiences. The Taguette program and B-learning methodologies as theoretical references were used to analyze the information. Results weaknesses were identified in factors related to the accessibility of users to the service, supplies, infrastructure, biosafety, training of health personnel, delivery of results to patients, and knowledge of the program by the users. Conclusions and implications for practice cervical cancer is a public health problem. Cervical cytology is the most widely used screening test; however, there are limitations in quality, so actions are proposed to improve the knowledge and skills of the nursing staff in their functions. The educational intervention effectively promoted comprehensive learning about taking cervical smears and allowed the nursing staff to share their experiences.


Subject(s)
Humans , Female , Adult , Young Adult , Vaginal Smears/nursing , Uterine Cervical Neoplasms/prevention & control , Cervix Uteri/cytology , Papanicolaou Test/nursing , Inservice Training , Nurses , Mass Screening , Women's Health , Papillomavirus Infections
3.
Health sci. dis ; 24(1): 109-112, 2023. figures, tables
Article in French | AIM | ID: biblio-1411349

ABSTRACT

Introduction. Le cancer du col utérin est le deuxième cancer de la femme au Cameroun. La radiothérapie reste une des modalités thérapeutiques phares dans la prise en charge de cette pathologie et l'État participe en y apportant une subvention. Toutefois, plusieurs patientes n'accèdent pas au traitement en raison des difficultés financières. Notre objectif était d'évaluer le coût réel de la prise en charge afin de servir de support aux politiques d'aide aux patientes. Méthodologie. Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. Au total 35 dossiers de patientes ont été inclus. Lespatientes avaient de faibles revenus (<108.810 XAF /mois, 51,3%), étaient sans assurance maladie (88,6%), provenant en majorité des villes hors de Douala (54,3%), avec des cancers localement évolués. Le coût global moyen du traitement était de 511 264 XAF+/-103479 XAF (779,42 +/-157,75 euros) pour chaque patiente. La durée moyenne de traitement était de 57,34 jours, avec un nombre médian de 27 séances. Les frais supplémentaires pendant le traitement provenaient de la chimiothérapie, de la gestion des effets secondaires, notamment des transfusions sanguines, et du bilan de suivi. Plus de la moitié des patientes ont eu besoin d'une prise en charge supplémentaire par chimiothérapie ou chirurgie. Conclusion. La prise en charge du cancer du col utérin par radiothérapie est coûteuse et peu accessible à la majorité des patientes Camerounaises.


Introduction.Cervix cancer is the second cancer among women in Cameroon. Radiotherapy is often warranted in its management. Many patients do not access treatment due to financial difficulties. Our objective was to assess the real cost of care in order to support patient assistance policies. Methodology. A descriptive cross over study of women treated by radiotherapy at the Douala General Hospital from October 2020 to January 2021 was conducted. Results. A total number of 35 patient files were included in the study. Patients generally had low income (<108.810 XAF /month), without medical insurance, lived out of Douala, and were diagnosed at locally advanced stages of their disease. Average cost of treatment for radiotherapy alone was 511,264 XAF +/-103,479 XAF. Average duration of treatment was 57.34 days, with a median number of 27 sessions. Extra cost came from chemotherapy, management of side effects especially from blood transfusions, and imaging. More than half of the patients required additional expense for adjunct chemotherapy or surgery. Conclusion. The total cost of treatment for cervix cancer by radiotherapy is quite expensive, and not accessible to the average Cameroonian


Subject(s)
Humans , Female , Radiotherapy , Uterine Cervical Neoplasms , Health Care Costs , Disease Management , Costs and Cost Analysis
4.
J. Health Biol. Sci. (Online) ; 10(1): 1-9, 01/jan./2022. tab
Article in Portuguese | LILACS | ID: biblio-1378520

ABSTRACT

Objetivos: avaliar a cobertura e os fatores associados à não realização do exame citopatológico do colo do útero entre mulheres de 18 a 39 anos no Brasil. Métodos: estudo transversal, de base populacional, com dados de inquérito domiciliar com 2.002 mulheres alfabetizadas de áreas urbanas, selecionadas por amostragem aleatória por conglomerados em 2016. Foram avaliados a prática do exame nos três anos anteriores e os fatores associados à não realização, com cálculo de razão de prevalência ajustada (RPaj) e intervalos de confiança de 95% (IC95%) por regressão de Poisson. Resultados: a cobertura do exame entre mulheres de 18-39 anos foi de 66,5%, sendo mais elevada naquelas de 35-39 anos (76,8%). Mulheres com renda familiar até 1 salário-mínimo (RPaj=2,08;IC95% 1,72-2,54), que estudaram até a 4a série (RPaj=2,30;IC95% 1,22-2,67), residentes na região Nordeste (RPaj=1,79;IC95% 1,34-2,09) e em municípios com até 20.000 habitantes (RPaj=3,15;IC95% 2,33-3,96) apresentaram maior prevalência de não realização do exame. Conclusão: a cobertura do exame citopatológico esteve abaixo do recomendado, com disparidades socioeconômicas e geográficas. Os dados sugerem necessidade de oportunizar o rastreamento entre mulheres jovens de maior risco para o câncer do colo do útero.


Objectives: to evaluate the coverage and factors associated with non-performing Pap smear test among women aged 18-39 years in Brazil. Methods: cross-sectional, population-based study with household survey data with 2,002 literate women from urban areas, selected by random sampling by clusters in 2016. The practice of Pap test in the previous three years and associated factors with non-participation were evaluated, with calculation of adjusted prevalence ratio (PRad) and 95% confidence intervals (95%CI) by Poisson regression. Results: coverage of Pap tests among women 18-39 years was 66.5%, being higher in those aged 35-39 years (76.8%). Women with a family income up to 01 minimum wage (PRad=2.08; 95%CI 1.72-2.54), who studied up to 4th grade (PRad=2.30; 95%CI 1.22-2.67) and residents in the Northeast region (PRad=1.79; 95%CI 1.34-2.09) and in municipalities up to 20,000 inhabitants (PRad=3.15; 95%CI 2.33-3.96) had a higher prevalence of non-participation in screening. Conclusions: the coverage of the Pap smear test was below recommended, with socioeconomic and geographical disparities. The data suggest the need to provide screening among young women at higher risk for cervical cancer.


Subject(s)
Papanicolaou Test , Women , Uterine Cervical Neoplasms , Cervix Uteri , Mass Screening , Health Surveys
5.
Arq. ciências saúde UNIPAR ; 26(3): 212-225, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399001

ABSTRACT

Este estudo teve como objetivo analisar o perfil dos casos de câncer de mama no estado do Acre no período de 2015 a 2019. Trata-se de um estudo quantitativo com delineamento transversal. A amostra foi constituída por todos os casos de câncer de mama registrados no Acre e inseridos no Departamento de Informática do Sistema Único de Saúde (DATASUS) no período de 2015 a 2019. Foram identificados no período 293 casos da doença, com maior número de casos registrados no ano de 2019 (25,0%), sendo a maioria do sexo feminino (98,0%), na faixa etária de 40 a 49 anos (29,0%). O tempo decorrido desde o diagnóstico até o início do tratamento foi de mais de 60 dias (51,0%). A modalidade terapêutica mais utilizada foi a quimioterapia (55,0%). O local da realização do tratamento ocorreu capital do estado Rio Branco (80,0%). A maior parte dos acometidos, ainda encontra-se em tratamento (56,0%), no entanto (44,0%) evoluiu para óbito. O aumento da doença com o passar dos anos é notável no Acre. É importante destacar que ações voltadas para a prevenção e controle do câncer de mama continuam sendo fundamentais para auxiliar na diminuição do número de casos, como o rastreamento e diagnóstico precoce.


This study aimed to analyze the profile of breast cancer cases in the state of Acre in the period from 2015 to 2019. This is a quantitative study with a cross-sectional design. The sample consisted of all breast cancer cases registered in Acre and inserted in the Informatics Department of the Unified Health System (DATASUS) in the period from 2015 to 2019. In the period 293 cases of the disease were identified, with a greater number of cases registered in 2019 (25.0%), with the majority being female (98.0%), aged 40 to 49 years (29.0%). The time elapsed from diagnosis to the start of treatment was more than 60 days (51.0%). The most used therapeutic modality was chemotherapy (55.0%). The place where the treatment was performed took place in the state of Rio Branco (80.0%). Most of the people affected are still under treatment (56.0%), however (44.0%) died. The increase in the disease over the years is notable in Acre. It is important to highlight that actions aimed at the prevention and control of breast cancer continue to be fundamental to assist in reducing the number of cases, such as screening and early diagnosis.


Este estudio tuvo como objetivo analizar el perfil de los casos de cáncer de mama en el estado de Acre en el período de 2015 a 2019. Se trata de un estudio cuantitativo con diseño transversal. La muestra consistió en todos los casos de cáncer de mama registrados en Acre e ingresados en el Departamento de Informática del Sistema Único de Salud (DATASUS) en el período de 2015 a 2019. En el periodo se identificaron 293 casos de la enfermedad, siendo el mayor número de casos registrados en 2019 (25,0%), siendo la mayoría mujeres (98,0%), en el grupo de edad de 40 a 49 años (29,0%). El tiempo transcurrido desde el diagnóstico hasta el inicio del tratamiento fue superior a 60 días (51,0%). La modalidad terapéutica más utilizada fue la quimioterapia (55,0%). El lugar donde se realizó el tratamiento fue Rio Branco, la capital del estado (80,0%). La mayoría de los pacientes afectados siguen en tratamiento (56,0%), sin embargo, (44,0%) fallecieron. El aumento de la enfermedad a lo largo de los años es notable en Acre. Es importante destacar que las acciones dirigidas a la prevención y control del cáncer de mama siguen siendo fundamentales para ayudar a reducir el número de casos, como el cribado y el diagnóstico precoz.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Health Profile , Breast Neoplasms/complications , Breast Neoplasms/mortality , Breast Neoplasms/prevention & control , Breast Neoplasms/epidemiology , Epidemiology , Therapeutics/instrumentation , Uterine Cervical Neoplasms/complications , Mass Screening , Cross-Sectional Studies/methods , Clinical Trials as Topic/methods , Morbidity , Early Diagnosis , Drug Therapy , Disease Prevention
6.
Arq. ciências saúde UNIPAR ; 26(3): 794-808, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399468

ABSTRACT

O câncer do colo do útero é considerado um dos cânceres mais comuns entre mulheres, representando um grande problema de saúde global, sendo a quarta causa mais frequente de morte por câncer na população feminina. Mediante a um estudo quantitativo e retrospectivo de dados pré- analíticos e analíticos das requisições do exame citopatológico do colo do útero, objetivou-se avaliar os resultados de exames citopatológicos de mulheres usuárias do SUS de um município do oeste do Paraná, realizados no período antes da pandemia COVID-19, de março de 2019 a fevereiro de 2020 e durante a pandemia COVID-19, de março de 2020 a fevereiro de 2021, dos exames citopatológicos alterados. Foram utilizadas as requisições de exames citopatológicos do Programa Nacional de Controle do CCU e o sistema eletrônico SISCAN como ferramentas de busca. Dentre os resultados, totalizaram-se 20.425 amostras processadas no período antes da pandemia, sendo 19.908 consideradas satisfatórias para análise oncótica, onde 1.148 (5,76%) amostras apresentaram alteração citológica. No período da pandemia, totalizaram-se 11.315 amostras processadas, sendo 11.149 amostras satisfatórias para análise oncótica, das quais 721 (6,47%) apresentaram alteração citológica. No período da pandemia, o estudo demostra que metade da população de mulheres usuárias do SUS em um município do oeste do Paraná encontra-se na faixa etária da população-alvo preconizada pelo MS, sendo que a maioria delas realizou seu exame citopatológico por motivo de rastreamento. Contudo, mesmo com a interrupção dos atendimentos eletivos, as mulheres continuaram realizando seus exames citopatológicos, sendo elucidado um discreto aumento de 0,71% das alterações citológicas no período da pandemia, quando comparado ao período anterior, demonstrando o cenário deste programa na pandemia COVID-19.


Cervical cancer is considered one of the most common cancers among women, representing a major global health problem, being the fourth most frequent cause of cancer death in the female population. Through a quantitative and retrospective study of pre-analytical and analytical data of requests for cervical cytopathological examination, the objective was to evaluate the results of cytopathological examinations of women using the SUS in a city in western Paraná, carried out in the period before during the COVID-19 pandemic, from March 2019 to February 2020, and during the COVID-19 pandemic, from March 2020 to February 2021, from the altered cytopathological exams. Requests for cytopathological exams from the National Control Program of the CCU and the SISCAN electronic system were used as search tools. Among the results, a total of 20.425 samples were processed in the period before the pandemic, 19.908 of which were considered satisfactory for oncotic analysis, where 1.148 (5,76%) samples showed cytological alterations. During the pandemic period, a total of 11.315 samples were processed, of which 11.149 were satisfactory for oncotic analysis, of which 721 (6,47%) showed cytological alterations. During the pandemic period, the study shows that half of the population of women using the SUS in a municipality in western Paraná is in the target population age group recommended by the MS, and most of them underwent their cytopathological examination due to tracking. However, even with the interruption of elective care, women continued to perform their cytopathological exams, with a slight increase of 0,71% in cytological changes during the pandemic period, when compared to the previous period, demonstrating the scenario of this program in the COVID-19 pandemic.


El cáncer de cuello uterino se considera uno de los cánceres más comunes entre las mujeres, representando un importante problema de salud mundial, siendo la cuarta causa más frecuente de muerte por cáncer en la población femenina. Mediante el estudio cuantitativo y retrospectivo de los datos preanalíticos y analíticos de los requisitos del examen citopatológico del útero, se evaluaron los resultados de los exámenes citopatológicos de las usuarias del SUS de un municipio del oeste de Paraná, realizados en el período anterior a la pandemia COVID-19, de marzo de 2019 a febrero de 2020, y durante la pandemia COVID-19, de marzo de 2020 a febrero de 2021, de los exámenes citopatológicos alterados. Se utilizaron como herramientas de búsqueda las requisiciones de exámenes citopatológicos del Programa Nacional de Control de UCC y el sistema electrónico SISCAN. Entre los resultados, un total de 20.425 muestras fueron procesadas en el período anterior a la pandemia, de las cuales 19.908 fueron consideradas satisfactorias para el análisis oncológico, donde 1.148 (5,76%) muestras presentaron alteración citológica. En el periodo de la pandemia, se procesaron un total de 11.315 muestras, de las cuales 11.149 fueron satisfactorias para el análisis oncológico, y 721 (6,47%) presentaron alteraciones citológicas. En el período de la pandemia, el estudio demuestra que la mitad de la población de mujeres usuarias del SUS en una ciudad del oeste de Paraná está en la franja de edad de la población objetivo recomendada por el MS, y la mayoría de ellas se sometió a un examen citopatológico con fines de cribado. Sin embargo, aún con la interrupción de la atención electiva, las mujeres continuaron realizando sus exámenes citopatológicos, siendo dilucidado un leve aumento de 0,71% de alteraciones citológicas en el período pandémico, cuando comparado con el período anterior, demostrando el escenario de este programa en la pandemia COVID-19.


Subject(s)
Humans , Female , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/prevention & control , Mass Screening/statistics & numerical data , Pandemics , COVID-19/diagnosis , Women , World Health Organization/organization & administration , Unified Health System , Uterine Cervical Neoplasms/complications , Causality , Retrospective Studies
7.
Poblac. salud mesoam ; 19(2)jun. 2022.
Article in Spanish | LILACS-Express | LILACS, SES-SP, SaludCR | ID: biblio-1386962

ABSTRACT

Resumen Introducción: el cáncer de cérvix es una de las enfermedades neoplásicas más frecuentes que afecta la salud de las mujeres en el mundo. Objetivo: determinar si existen diferencias entre regiones de Costa Rica en el uso del papanicoláu, con el fin de visualizar las inequidades relacionadas con la detección temprana del cáncer cérvico-uterino. Metodología: este estudio se realizó a partir de la Encuesta Nacional de Hogares de 2014, la cual es representativa en el ámbito nacional. Se utilizó R-Studio para estimar dos modelos de regresión multinomial que explican el tiempo transcurrido desde el último papanicoláu y las razones por las que las mujeres nunca se habían realizado uno. Se recurrió a datos del Registro Nacional de Tumores del Ministerio de Salud para evaluar la razón in-situ/invasor. Resultados: en comparación con las residentes de la región Central, las mujeres de las regiones Chorotega, Pacífico Central y Huetar Caribe son respectivamente un 80 % (OR=1,80; p<0,01), un 52 % (OR=1,52; p=0,031) y un 58 % (OR=1,58; p<0,01) más propensas a haberse realizado la citología vaginal por última vez hace 5 años o más que hace 1 o 2 años. Discusión: de acuerdo con los resultados de la presente investigación, la Región Chorotega presenta las condiciones más desventajosas en cuanto a la práctica de PAP, esto implica un mayor riesgo de desarrollar lesiones y cáncer de cérvix. Conclusiones: en busca de reducir las brechas y mejorar las condiciones de acceso, es necesario coordinar y articular esfuerzos institucionales tanto gubernamentales como no gubernamentales, incluyendo la participación y el protagonismo de las mujeres.


Abstract Introduction. Cervical cancer is one of the most common cancer types that affects the health of women worldwide. Objective: To determine if there are differences in the use of Pap smears at the regional level in Costa Rica, in order to visualize the inequalities related to the early detection of cervical-uterine cancer. Methodology. This study was conducted based on information from the 2014 National Household Survey. This survey is representative at the national level. R-Studio was used to estimate two multinomial regression models. The first one was used to explain the time that has elapsed since the last time women had a Pap smear. The second one was used to explain the reasons why women had never had a Pap smear. Data on the incidence of cervical cancer, from the National Tumor Registry of the Ministry of Health, were used in order to estimate the in-situ/invasive ratio. Results: Women who participate less regularly in screening are those residing in the Chorotega, Central Pacific and Huetar Caribbean regions. Compared to women in the Central region, women in these three regions are 80% (OR=1.80; p<0.01), 52% (OR=1.52; p=0.031) and 58% (OR=1.58; p<0.01) respectively more likely to have had a Pap screening 5 or more years ago, as compared to 1 to 2 years ago. Discussion: According to the results of this research, the Chorotega Region presents the most disadvantageous conditions in terms of the use of PAP, which represents a higher risk for women to develop lesions and cervical cancer. Conclusions: In order to reduce gaps and improve conditions of access to prevention, it is necessary to coordinate institutional efforts, both governmental and non-governmental, as well as the participation and protagonism of women.


Subject(s)
Humans , Female , Uterine Cervical Neoplasms , Early Detection of Cancer , Health Inequities , Costa Rica
8.
Säo Paulo med. j ; 140(3): 349-355, May-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1377377

ABSTRACT

ABSTRACT BACKGROUND: Cervical cancer is a type of cancer caused by human papillomavirus (HPV). OBJECTIVE: To determine the relationship between awareness of cervical cancer and HPV infection and attitudes towards HPV vaccine among women aged 15-49 years. DESIGN AND SETTING: Cross-sectional study conducted at Karabük Training and Research Hospital, Turkey. METHODS: 500 women who visited the gynecology outpatient clinic of a public hospital between July 15 and December 31, 2019, were selected through random sampling. Data were collected using a sociodemographic questionnaire comprising nine questions (created by the researchers), the HPV and Cervical Cancer Awareness Questionnaire and the Carolina HPV Immunization Attitudes and Beliefs Scale. RESULTS: The relationship between the awareness questionnaire and the beliefs scale was explained through simple effect modeling of a structural equation. The women's knowledge score regarding cervical cancer and HPV infection was 4.69 ± 4.02 out of 15. Women were afraid of being diagnosed with cervical cancer and HPV infection, but they did not have sufficient information. They had poor information about the HPV vaccine, did not know how to obtain the vaccine and did not have enough information about its benefits and harmful effects. Women who were afraid of getting cervical cancer, and who thought that they were at risk, had more information about the HPV vaccine. CONCLUSION: Women need information about cervical cancer, HPV infection and the HPV vaccine. Midwives, nurses and physicians who provide healthcare services in gynecological follow-ups should provide information to women about the HPV vaccine and cervical cancer.


Subject(s)
Uterine Cervical Neoplasms/prevention & control , Papillomavirus Infections , Papillomavirus Vaccines , Health Knowledge, Attitudes, Practice , Cross-Sectional Studies , Surveys and Questionnaires
9.
Rev. chil. infectol ; 39(2): 117-225, abr. 2022. ilus, tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388345

ABSTRACT

INTRODUCCIÓN: En Chile, el cáncer de cuello uterino (CCU) es la segunda causa de muerte por neoplasias malignas en la mujer. El principal agente causal es el virus papiloma humano (VPH). Comparando con la población general, los o las trabajadoras(es) sexuales (TS) tienen alto riesgo de adquirir VPH. OBJETIVO: Analizar la prevalencia y genotipos del VPH cervical y vaginal en TS que se atienden en un Centro de Salud Sexual de Santiago, Chile. Pacientes y MÉTODO: Se realizó un estudio transversal en 97 mujeres TS, de 19 a 70 años de edad. Se obtuvieron dos muestras por paciente, una de exocérvix y otra de paredes vaginales. El ADN de VPH fue identificado por reacción de polimerasa en cadena (RPC) y su genotipo fue investigado para 32 tipos de VPH. RESULTADOS: La prevalencia de VPH global fue de 45%, observándose portación cervical en 41,2% y vaginal en 36,1%, con una coinfección de 32%. El 63% de las muestras tenía genotipos de alto riesgo. Los VPH de alto riesgo más frecuentes fueron el VPH 66 (12%), VPH 58 (9,3%), seguidos por VPH 16, VPH 59 y VPH 82 con igual frecuencia (8% c/u). Treinta y dos mujeres (43%) fueron infectadas con genotipos múltiples. CONCLUSIÓN: El VPH es una infección frecuente entre las TS. Este es el primer estudio en Chile sobre prevalencia y genotipos de VPH en TS.


BACKGROUND: In Chile, cervical cancer is the second leading cause of death from malignancy in women. The main causal agent of cervical cancer is the human papillomavirus (HPV). Compared with the general population, sex workers (SW) are at increased risk of acquiring HPV. AIM: To analyze the prevalence and genotypes of cervical and vaginal HPV in female SW attending a Sexual Control Centre. METHODS: A cross-sectional study was carried out on 97 women (19-70 years old). Two samples were taken per patient, one from exocervix and the other from vaginal walls. HPV DNA. was identified by polymerase chain reaction (PCR) and genotyping using specific probes for 32 types of HPV. RESULTS: The overall frequency of HPV was 45%, 41.2% in cervical carrier and 36.1% in vaginal carrier, 32% were co-infected, 63% of HPV were high-risk genotypes. The most frequent high-risk HPV was HPV 66 (12%), HPV 58 (9.3%), followed by HPV 16, HPV 59 and HPV 82 with the same frequency (8% each one). Thirty two (43%) of females were infected with multiple genotypes. CONCLUSION: HPV is frequent infection among SW. This is the first study in Chile on the prevalence and genotypes of HPV in sex workers.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Young Adult , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/epidemiology , Papillomavirus Infections/epidemiology , Alphapapillomavirus/genetics , Sex Workers , Papillomaviridae/genetics , DNA, Viral/analysis , DNA, Viral/genetics , Chile/epidemiology , Prevalence , Cross-Sectional Studies , Genotype
10.
Rev. Méd. Inst. Mex. Seguro Soc ; 60(2): 164-170, abr. 2022. ilus, tab
Article in Spanish | LILACS | ID: biblio-1367405

ABSTRACT

Introducción: a pesar de que la técnica de papanicolaou es el método más eficaz para la prevención y detección del cáncer cervicouterino, la precisión de esta herramienta sigue siendo controversial; debido a esto, existen esfuerzos médicos y científicos para mejorar la calidad del procedimiento. Objetivo: comparar la calidad en la toma de muestra entre la técnica convencional y la modificada. Material y métodos: estudio observacional descriptivo y comparativo en 150 muestras de citología cervical (75 muestras técnica convencional y 75 en técnica modificada) en mujeres de 25 a 64 años. Se analizaron variables emográficas, características del cérvix y calidad de la muestra. Se realizó estadística descriptiva y medidas de asociación. Estudio con riesgo mayor que el mínimo. Todas las participantes firmaron consentimiento informado. Resultados: la calidad de la muestra fue satisfactoria en el 92% para la técnica convencional frente al 89.3% para la técnica modificada. La causa principal de muestras insatisfactorias fue la celularidad insuficiente, la cual se presentó en el 6.7% de las muestras con técnica convencional frente al 12% de la técnica modificada, sin diferencia significativa entre ambas técnicas p = 0.575 (1.37; 0.45-4.1), hallazgos que rechazan la hipótesis de trabajo. Conclusiones: no hubo diferencia significativa al utilizar ambas pruebas, las muestras con calidad satisfactoria fueron similares entre ambas técnicas.


Background: Despite the fact that the Papanicolaou technique is the most effective method of prevention and detection of cervical cancer, the precision of this tool remains controversial; Because of this, there are medical and scientific efforts to improve the quality of the procedure. Objective: Compare the quality of sampling between the conventional and modified technique. Material and methods: Descriptive and comparative observational study in 150 cervical cytology samples (75 conventional technique samples and 75 in modified technique) in women aged 25 to 64 years. Demographic variables, characteristics of the cervix and quality of the sample were analyzed. Descriptive statistics and association measures were performed. Study with risk greater than the minimum. All participants signed an informed consent. Results: The quality of the sample was satisfactory in 92.0% for the conventional technique vs 89.3% for the modified technique. The main cause of unsatisfactory samples was insufficient cellularity 6.7% in conventional technique vs 12% of the modified technique, with no significant difference between both techniques p = 0.575 (1.37; 0.45-4.1), findings that reject the working hypothesis. Conclusions: There was no significant difference when using both tests, the samples with satisfactory quality were similar between both techniques.


Subject(s)
Humans , Female , Adult , Middle Aged , Uterine Cervical Neoplasms/diagnosis , Papanicolaou Test/methods , Quality Control , Prospective Studies , Risk Assessment , Saline Solution
11.
Oncología (Ecuador) ; 32(1): 27-39, 30-04-2022.
Article in Spanish | LILACS | ID: biblio-1368926

ABSTRACT

Introducción: La cuarta parte de las mujeres con neoplasias ginecológicas cursa con obstrucción en la vía urinaria, secundaria a infiltración tumoral o compresión extrínseca de los uréteres. La nefrostomía es la alternativa clínica intervencionista para mejorar la nefropatía obstructiva y evitar el tratamiento de diálisis en un paciente oncológico con hidronefrosis. El presente estudio tiene el objetivo de determinar la supervivencia de pacientes con cáncer de cérvix portadoras de nefrostomía. Metodología: El presente estudio observacional se realizó en el Hospital Solón Espinosa Ayala "Solca-Núcleo de Quito" de enero-2014 a diciembre-2018. El cálculo muestral fue no probabilístico, se incluyeron casos de pacientes con cáncer de cérvix con nefrostomía. Las variables fueron: edad, su-pervivencia global, supervivencia con nefrostomía, tipo histológico de la neoplasia de cérvix, estadío, tratamiento oncológico luego de la nefrostomía, complicaciones y repuesta al tratamiento. Para el análisis se usó el método Kaplan Meier. Se analiza supervivencia según estadios funcionales ECOG . Resultados: Se incluyeron 96 casos en el estudio. La media de sobrevida luego de colocar la nefros-tomía fue de 277 días (9.2 meses), y la media de la sobrevida global fue de 462 días (15 meses). Las pacientes con ECOG-0 la supervivencia global fue de 625 días (20.8 meses), con ECOG 1, 2 y 3 fue de 437 días (14.5 meses) P= 0.013. Conclusión: Es este estudio las pacientes con cáncer de cérvix que tienen enfermedad localmente avanzada y metastásica con ECOG 0, son las más beneficiadas del procedimiento de nefrostomía con mejoría de la supervivencia. Las pacientes con enfermedad localmente avanzada y metastásica con ECOG 2 y 3, no mejoraron su sobrevida global con la colocación de nefrostomía, ya que a pesar de que recibieron tratamiento oncológico el 50% de ellas progresaron, pero evitaron el ingreso a programas de diálisis. La principal complicación luego de la colocación del catéter de nefrostomía fue la infección.


Introduction: A quarter of women with gynecological neoplasms present with obstruction in the urinary tract, secondary to tumor infiltration or extrinsic compression of the ureters. Nephrostomy is an interventional clinical alternative to improve obstructive nephropathy and avoid dialysis treatment in a cancer patient with hydronephrosis. The objective of this study was to determine the survival of patients with cervical cancer who underwent nephrostomy. Methodology: The present observational study was carried out at Solón Espinosa Ayala Hospital "Solca-Núcleo de Quito" from January 2014 to December 2018. The sample calculation was nonprobabilistic. Cases of patients with cervical cancer who underwent nephrostomy were included. The variables were age, overall survival, survival with nephrostomy, histological type of cervical neo-plasia, stage, oncological treatment after nephrostomy, complications, and response to treatment. For the analysis, the Kaplan­Meier method was used. Survival was analyzed according to ECOG func-tional stages. Results: Ninety-six cases were included in the study. The median survival after nephrostomy place-ment was 277 days (9.2 months), and the median overall survival was 462 days (15 months). Pa-tients with ECOG-0 had an overall survival of 625 days (20.8 months); those with ECOG 1, 2, and 3 had an overall survival of 437 days (14.5 months) (P= 0.013). Conclusion: In this study, patients with cervical cancer who had locally advanced and metastatic disease with ECOG 0 benefited the most from the nephrostomy procedure with improved survival. Patients with locally advanced and metastatic disease with ECOG scores of 2 and 3 did not improve their overall survival with nephrostomy placement. Fifty percent of them progressed despite receiving cancer treatment, but they avoided admission to dialysis programs. The main complication after placement of the nephrostomy catheter was an infection.


Subject(s)
Humans , Female , Survival Analysis , Uterine Cervical Neoplasms , Hydronephrosis , Nephrostomy, Percutaneous
12.
Saúde Colet. ; 12(74): 9947-9960, mar.2022. ilus
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1412309

ABSTRACT

Objetivo: Descrever o perfil sociodemográfico, dos exames do colo uterino e identificar as principais condutas realizadas pela enfermeira frente aos resultados encontrados nos exames citológicos de uma Estratégia Saúde da Família de Manaus. Método: Estudo quantitativo, descritivo, retrospectivo e exploratório, de análise de dados secundários dos prontuários e livro de registro dos exames citológicos realizados no período de janeiro a dezembro de 2018. Resultados: Foram realizados 217 exames, dos quais, seguindo critérios de inclusão 203 compuseram a amostra final. O perfil sociodemográfico, mostrou prevalência da faixa etária de 30-39 anos, casadas, ensino médio completo e do lar. Os exames apresentaram amostra satisfatória para avaliação, as microbiologias predominantes foram Lactobacillus e Gardenerella. A inflamação foi identificada como alteração celular benigna reativa ou reparativa mais evidente. Conclusão: Conhecer a realidade da população onde desempenha suas atividades é fator de grande relevância para que se possam estabelecer intervenções adequadas a realidade local.(AU)


Objective: To describe the sociodemographic profile and the examinations of the uterine cervix and identify the main procedures performed by the nurse in view of the results found in the cytological examinations of a Family Health Strategy in Manaus. Method: Quantitative, descriptive, retrospective and exploratory study, analyzing secondary data from medical records and registry book of cytological exams performed in the period from January to December 2018. Results: 217 exams were performed, of which, following inclusion criteria, 203 made up the final sample. The sociodemographic profile showed a prevalence in the age group of 30-39 years old, married, completed high school and at home. The exams showed a satisfactory sample for evaluation, the predominant microbiologies were Lactobacillus and Gardenerella. Inflammation was identified as the most evident benign reactive or reparative cell alteration. Conclusion: Knowing the reality of the population where they carry out their activities is a factor of great relevance so that interventions that are appropriate to the local reality can be established.(AU)


Objetivo: Describir el perfil sociodemográfico y los exámenes del cuello uterino e identificar los principales procedimientos realizados por la enfermera a la vista de los resultados encontrados en los exámenes citológicos de una Estrategia de Salud de la Familia en Manaus. Método: Estudio cuantitativo, descriptivo, retrospectivo y exploratorio, analizando datos secundarios de historias clínicas y libro registro de exámenes citológicos realizados en el período de enero a diciembre de 2018. Resultados: se realizaron 217 exámenes, de los cuales, siguiendo criterios de inclusión, 203 conformados la muestra final. El perfil sociodemográfico mostró una prevalencia del grupo de edad de 30 a 39 años, casados, bachillerato completo y amas de casa. Los exámenes arrojaron una muestra satisfactoria para la evaluación, las microbiologías predominantes fueron Lacto- bacillus y Gardenerella. La inflamación se identificó como la alteración celular benigna reactiva o reparadora más evidente. Conclusión: Conocer la realidad de la población donde desarrollan sus actividades es un factor de gran relevancia para que se puedan establecer intervenciones adecuadas a la realidad local.(AU)


Subject(s)
Female , Adult , Uterine Cervical Neoplasms , Disease Prevention , Papanicolaou Test , Nurses, Male
13.
Saúde Colet. ; 12(74): 9993-10010, mar.2022. tab
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1412432

ABSTRACT

Objetivo: Conhecer a ótica do enfermeiro atuante na Estratégia de Saúde Família na esfera da prevenção do câncer de colo do útero. Método: Pesquisa quanti e qualitativa, envolvendo 13 enfermeiros das Estratégias de Saúde da Família de um município do interior do estado de São Paulo e um de Minas Gerais. Os dados quantitativos foram tabulados no Excel, e os qualitativos analisados pelo software Iramuteq, além da abordagem temática de Minayo. Resultado: Organizado de acordo com sua frequência, agrupado em uma nuvem de palavras e dividido em 4 categorias. Conclusão: O Papanicolau e vacinação contra o HPV são importantes pilares da prevenção do câncer de colo uterino, porém as mulheres demostram resistência em aderir ao exame, principalmente devido a fatores como o medo, desconhecimento e vergonha. A importância do rastreamento deve ser constantemente pautada na comunidade pelo enfermeiro e sua equipe(AU)


Objective: To understand the perspective of nurses working in the Family Health Strategy in the sphere of cervical cancer prevention. Method: Quantitative and qualitative research, involving 13 nurses from the Family Health Strategies in a municipality in the interior of the state of São Paulo and one in Minas Gerais. Quantitative data were tabulated in Excel, and qualitative data were analyzed using the Iramuteq software, in addition to Minayo's thematic approach. Result: Organized according to frequency, grouped in a word cloud and divided into 4 categories. Conclusion: Pap smears and HPV vaccination are important pillars in the prevention of cervical cancer, but women show resistance to adhering to the test, mainly due to factors such as fear, ignorance and shame. The importance of tracking must be constantly guided in the community by nurses and their staff.(AU)


Objetivo: Conocer la perspectiva de los enfermeros que trabajan en la Estrategia Salud de la Familia en el ámbito de la prevención del cáncer . Método: Investigación cuantitativa y cualitativa, que involucró a 13 enfermeros de las Estrategias de Salud de la Familia en un municipio del interior del estado de São Paulo y uno en Minas Gerais. Los datos cuantitativos se tabularon en Excel y los datos cualitativos se analizaron utilizando el software Iramuteq, además del enfoque temático de Minayo. Resultado: organizado por frecuencia, agrupado en una nube de palabras y dividido en 4 categorías. Conclusión: el Papanicolaou y la vacunación contra el VPH son pilares importantes en la prevención del cáncer de cuello uterino, pero las mujeres muestran resistencia a la adhesión, principalmente por factores como el miedo, el desconocimiento y la vergüenza. La importancia del seguimiento debe ser guiada constantemente en la comunidad por enfermeras y su personal.(AU)


Subject(s)
Uterine Cervical Neoplasms , Women's Health , Nurses, Male , Papanicolaou Test
14.
Rev. colomb. cancerol ; 26(1): 117-123, ene.-mar. 2022. graf
Article in Spanish | LILACS | ID: biblio-1407974

ABSTRACT

Resumen El cáncer de cuello uterino ocupa el cuarto lugar dentro de las neoplasias de origen ginecológico a nivel global, representando un 85% de los casos en países en vías de desarrollo. Las metástasis cutáneas de origen ginecológico son altamente infrecuentes, observándose con mayor frecuencia en las neoplasias malignas de ovario, seguidas del adenocarcinoma endometrial y de cuello uterino y, menos frecuentemente, las de subtipo escamocelular. En la actualidad, existen alrededor de 80 reportes de casos citados en la literatura de metástasis cutáneas secundarias a un carcinoma de cuello uterino; sin embargo, ninguno con localización en la piel del cuello que se origine de un subtipo histológico escamocelular. En Colombia, no hay casos reportados hasta la fecha. Se presenta el caso de una paciente de 43 años que consulta por sangrado vaginal, dolor abdominal y una extensa placa tumoral exofítica de aspecto metastásico en la piel del cuello y del hombro izquierdo, encontrando al examen clínico inicial una masa tumoral en el cuello uterino con confirmación histológica de un carcinoma escamocelular como neoplasia primaria. Se hace diagnóstico de Carcinoma de cuello uterino estadio IVB y se inicia un tratamiento con intención paliativa con radioterapia y posterior quimioterapia sistémica. La enfermedad metastásica de origen ginecológico a nivel cutáneo confiere un mal pronóstico, con una supervivencia reportada de 1 a 37 meses después de su diagnóstico, por lo cual se deduce que la prevención y el diagnóstico temprano, particularmente en cáncer de cuello uterino, es de vital importancia en la población general.


Abstract Cervical cancer is the fourth most common cancer among gynecological neoplasms globally, representing 85% of cases in developing countries. Cutaneous metastases of gynecological origin are very rare, observed more frequently in ovarian malignancies, followed by endometrial and cervical adenocarcinoma and less frequently those of the squamous cell subtype. Currently there are about 80 case reports cited in the literature of cutaneous metastases secondary to cervical carcinoma, however, none with localization in the skin of the neck originated from a squamous cell histological subtype. In Colombia, there are no reported cases to date. We present the case of a 43-year-old patient who consulted for abdominal pain, vaginal bleeding and an extensive exophytic tumor plaque of metastatic appearance in the skin of the neck and left shoulder, finding a tumor mass in the cervix with histological confirmation of a squamous cell carcinoma as primary tumor. A diagnosis of stage IVB cervical carcinoma is made, and treatment is initiated with palliative intention with radiotherapy and subsequent systemic chemotherapy. Cutaneous metastatic disease of gynecological origin confers a poor prognosis, with a reported survival of 1 to 37 months after its diagnosis, for which prevention and early diagnosis, particularly in cervical cancer, is of vital importance in the general population.


Subject(s)
Humans , Female , Adult , Carcinoma, Squamous Cell , Uterine Cervical Neoplasms , Cervix Uteri , Adenocarcinoma , Neoplasm Metastasis
15.
Nursing (Säo Paulo) ; 25(285): 7272-7281, fev.2022.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1371986

ABSTRACT

Objetivo: Identificar a atuação do enfermeiro na detecção precoce do câncer de colo do uterino. Método: Trata-se de uma revisão integrativa, realizada em 2021, nas bases de dados SCIELO, PUBMED, LILACS, com os descritores: Neoplasias do Colo do Útero, Enfermagem e Cuidado Centrado no Paciente. A amostra foi de 16 artigos. Resultados: dentre as atuações do enfermeiro destacam-se: Educação em saúde sobre detecção precoce do câncer do colo uterino e incentivo à realização do exame citopatológico; orientação de enfermagem quanto a importância do uso de preservativo nas relações sexuais; consulta de enfermagem, realização do exame citopatológico; vacinação contra HPV; diagnóstico e tratamento precoces. Conclusão: O enfermeiro tem função primordial no decorrer de todo o processo de prevenção e promoção de saúde do câncer de colo uterino, prestando uma assistência integral e humanizada(AU)


Objective: To identify the role of nurses in the early detection of cervical cancer. Method: This is an integrative review, carried out from April to June 2021, in the SCIELO, PUBMED, LILACS databases, with the descriptors: Cervical Neoplasms, Nursing and Patient-Centered Care. Were found 1,389 articles, but the sample consisted of 16 articles. Results: among the nurses' actions, the following stand out: Health education on early detection of cervical cancer and encouragement to perform the Pap smear; nursing guidance on the importance of using condoms during sexual intercourse; nursing consultation, Pap smear test; HPV vaccination; early diagnosis and treatment. Conclusion: The nurse has a primary role throughout the entire process of prevention and health promotion of cervical cancer, providing comprehensive and humanized care.(AU)


Objetivo: Identificar el papel del enfermero en la detección precoz del cáncer cervicouterino. Método: Se trata de una revisión integradora, realizada de abril a junio de 2021, en las bases de datos SCIELO, PUBMED, LILACS, con los descriptores: Neoplasias Cervicales, Enfermería y Atención Centrada en el Paciente. Se encontraron 1389 artículos, pero la muestra estuvo conformada por 16 artículos. Resultados: entre las acciones de las enfermeras se destacan las siguientes: Educación en salud para la detección temprana del cáncer de cuello uterino y estímulo para la realización del Papanicolaou; orientación de enfermería sobre la importancia de usar condones durante las relaciones sexuales; consulta de enfermería, prueba de Papanicolaou; Vacunación contra el VPH; diagnóstico y tratamiento precoces. Conclusión: La enfermera tiene un rol primordial en todo el proceso de prevención y promoción de la salud del cáncer de cuello uterino, brindando una atención integral y humanizada(AU)


Subject(s)
Uterine Cervical Neoplasms , Nursing , Patient-Centered Care
16.
Rev. Assoc. Med. Bras. (1992) ; 68(2): 234-238, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365363

ABSTRACT

SUMMARY OBJECTIVE: The objective of this study was to verify whether the parameters of the blood count and the fasting glucose level before treatment are related to prognosis and survival in cervical cancer (IIB-IVB staging). METHODS: Patients with cervical cancer (stages IIB-IVB) were evaluated (n=80). Age, parity, staging, histological grade, histological type, hemoglobin, red blood cells, hematocrit, neutrophil, lymphocyte and platelet counts, red blood cell distribution width, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, fasting glucose levels, overall survival, and disease-free survival were evaluated. The results of laboratory parameters were compared using the Mann-Whitney U test. Receiver operating characteristic curve was used to obtain the area under the curve and determine the best cutoff values for each parameter. Survival was verified by using the Kaplan-Meier method, followed by the log-rank test. The level of significance was ≤0.05. RESULTS: Regarding staging, lower hemoglobin values (p=0.0013), red blood cells (p=0.009), hematocrit (p=0.0016), higher leukocytes (p=0.0432), neutrophils (p=0.0176), platelets (p=0.0140), red blood cell distribution width (RDW) (p=0.0073), neutrophil-lymphocyte ratio (p=0.0039), platelet-lymphocyte ratio (p=0.0006), and fasting glucose level (p=0.0278) were found in IIIA-IVB compared with IIB staging. Shorter disease-free survival was associated with hemoglobin ≤12.3 g/dl (p=0.0491), hematocrit ≤38.5% (p=0.05), neutrophil-lymphocyte ratio >2.9 (p=0.0478), and platelet-lymphocyte ratio >184.9 (p=0.0207). Shorter overall survival was associated with hemoglobin ≤12.3 g/dl (p=0.0131), hematocrit ≤38.5% (p=0.0376), neutrophil-lymphocyte ratio >2.9 (p=0.0258), and platelet-lymphocyte ratio >184.9 (p=0.0038). CONCLUSION: The analysis of these low-cost and easily accessible parameters could be a way to monitor patients in order to predict treatment failures and act as early as possible.


Subject(s)
Humans , Female , Pregnancy , Blood Glucose , Uterine Cervical Neoplasms , Prognosis , Retrospective Studies , Fasting
17.
Article in English | LILACS | ID: biblio-1400940

ABSTRACT

Bacterial vaginosis is the most common cause of vaginal discharge and occurs when there is an imbalance in the vaginal microbiota, predominantly composed of Lactobacillus spp. Human Papillomavirus is the most common sexually transmitted virus in the world. Persistent infection with high-risk Human Papillomavirus genotypes is the main cause of the development of cervical intraepithelial neoplasia and cervical cancer. Objective: To investigate the association between bacterial vaginosis and cervical Human Papillomavirus infection and between bacterial vaginosis and cervical cytological abnormalities in adult women. Methods: Cross-sectional study carried out in a gynecology outpatient clinic of the public health network. A total of 202 women were included in the study and underwent gynecological examination with cervical specimen collection. Cervical cytopathological examinations and bacterioscopy by the Nugent method were performed to identify bacterial vaginosis, and PCR and reverse hybridization were carried out for Human Papillomavirus detection and genotyping. Bivariate analysis was performed to investigate the association between bacterial vaginosis and cervical Human Papillomavirus infection, and between bacterial vaginosis and cervical cytological abnormalities. The odds ratio was calculated, with the respective 95% confidence intervals (95%CI) and 5% significance level (p≤0.05). Results: The prevalence of bacterial vaginosis was 33.2% (67/202), the prevalence of cervical Human Papillomavirus infection was 38.6% (78/202) and the prevalence of cervical cytological abnormalities was 6.0% (12/202). Bivariate analysis showed no significant association between bacterial vaginosis and cervical Human Papillomavirus infection (OR 0.69; 95% CI 0.37­ 1.27; p=0.23), or between bacterial vaginosis and cervical cytological abnormalities (OR 0.65; 95%CI 0.17­2.50; p=0.54). Conclusion: In this study, bacterial vaginosis did not represent a risk factor for cervical Human Papillomavirus infection or for the presence of cervical cytological abnormalities in the investigated adult women.


A vaginose bacteriana é a causa mais comum de corrimento vaginal e ocorre quando há um desequilíbrio da microbiota vaginal, composta predominantemente de Lactobacillus spp. O papilomavírus humano é o vírus sexualmente transmissível mais comum no mundo. A infecção persistente com genótipos do papilomavírus humano de alto risco é a principal causa do desenvolvimento de neoplasias intraepiteliais cervicais e câncer de colo do útero. Objetivo: Investigar a associação entre vaginose bacteriana e infecção cervical pelo papilomavírus humano e entre vaginose bacteriana e anormalidades citológicas cervicais em mulheres adultas. Métodos: Estudo de corte transversal realizado em um ambulatório de ginecologia da rede pública de saúde. O total de 202 mulheres foi incluído no estudo e submetido ao exame ginecológico com coleta de espécime cervical. Foram realizados os exames citopatológicos cervicais, a bacterioscopia pelo método de Nugent para a identificação da vaginose bacteriana e reação em cadeia da polimerase e hibridização reversa para a detecção e genotipagem do papilomavírus humano. Análise bivariada foi realizada para investigar a associação entre vaginose bacteriana e infecção cervical pelo papilomavírus humano e entre vaginose bacteriana e anormalidades citológicas cervicais. Foi calculado o odds ratio, com os respectivos intervalos de confiança de 95% (IC95%) e nível de significância de 5% (p≤0,05). Resultados: A prevalência da vaginose bacteriana foi de 33,2% (67/202), a da infecção cervical pelo papilomavírus humano foi de 38,6% (78/202) e a de anormalidades citológicas cervicais foi de 6,0% (12/202). A análise bivariada não demonstrou associação significativa entre vaginose bacteriana e infecção cervical pelo papilomavírus humano (OR 0,69; IC95% 0,37­1,27; p=0,23), nem entre vaginose bacteriana e anormalidades citológicas cervicais (OR 0,65; IC95% 0,17­2,50; p=0,54). Conclusão: Neste estudo a vaginose bacteriana não representou um fator de risco para a infecção cervical pelo papilomavírus humano e nem para presença de anormalidades citológicas cervicais nas mulheres adultas investigadas


Subject(s)
Humans , Vaginosis, Bacterial , Cervical Intraepithelial Neoplasia , Papillomavirus Infections , Uterine Cervical Neoplasms , Persistent Infection , Lactobacillus
18.
Alerta (San Salvador) ; 5(1): 81-87, ene. 28, 2022. ilus
Article in Spanish | LILACS, BISSAL | ID: biblio-1354473

ABSTRACT

El cáncer de cuello uterino es la cuarta causa de mortalidad por cáncer en mujeres; 88 % de los casos provienen de países en vías de desarrollo debido al escaso acceso al tamizaje y tratamiento. Debido a esto, en los países de bajo desarrollo humano estrategias como la autotoma para la detección del virus del papiloma humano han adquirido gran importancia en la actualidad, aumentando hasta en un 45 % el tamizaje en estos países. La presente revisión bibliográfica tiene como objetivo determinar si existen diferencias entre técnica convencional para detección del virus del papiloma humano y la autotoma en países de mediano y bajo desarrollo humano, así como las ventajas y limitantes que esta presenta. Se realizó la búsqueda de la literatura mediante las bases de datos PubMed, Google Scholar y SciELO, empleando artículos originales, ensayos clínicos, de revisión, entre otros. Se demostró que la autotoma para la detección del virus del papiloma humano tiene una especificidad similar a la toma convencional por parte de personal médico y que incrementa el tamizaje, ya que es más aceptada que la muestra tomada por el clínico debido a que facilita el acceso y aborda las limitantes socioculturales percibidas por las usuarias


Cervical cancer is the fourth leading cause of cancer mortality in women; 88% of cases come from developing countries due to poor access to screening and treatment. Due to this, in countries with low human development, strategies such as self-testing for the detection of human papillomavirus have become very important today, increasing screening in these countries by up to 45%. The objective of this bibliographical review is to determine if there are differences between the conventional technique for detecting the human papillomavirus and self-testing in countries with medium and low human development, as well as the advantages and limitations that it presents. The literature search was carried out using the PubMed, Google Scholar and SciELO databases, using original articles, clinical trials, reviews, among others. It was shown that self-sampling for the detection of human papillomavirus has a similar specificity to conventional sampling by medical personnel and that it increases screening, since it is more accepted than the sample taken by the clinician because it facilitates access. and addresses the sociocultural limitations perceived by users


Subject(s)
Women , Uterine Cervical Neoplasms , Mass Screening , Alphapapillomavirus , Self-Testing , Methods , Neoplasms
20.
Article in English | LILACS | ID: biblio-1369046

ABSTRACT

Introduction: Cervical cancer is the third most common malignant tumor in the female population and the fourth cause of death from cancer in women in Brazil. The squamocolumnar junction and the transformation zone concentrate 90% of pre-invasive and invasive cervical lesions. Objective: To evaluate the prevalence of cytology without cells of the squamocolumnar junction and feasibility of active search. Methods: Cross-sectional study at a university hospital between 2017 and 2018. The prevalence of cytology without squamocolumnar junction cells was calculated. A convenience sample was obtained and mean age and relationship with presence of transformation zone cells were calculated. An active search was performed and cytology collected, with estrogen preparation if indicated. Medical records of the other women were analyzed. Results: Squamocolumnar junction cells were not found in 28.84% of samples. Mean age was 53 years, without association with presence of squamocolumnar junction cells (p=0.409). Seventy-six women returned, 36 of which (47.37%) used estrogen. Level 2 or 3 cervical intraepithelial neoplasia, microinvasive carcinoma or cancer was not identified. A total of 134 medical records were analyzed; only 36 women (26.87%) completed screening. Conclusions: The presence of squamocolumnar junction cells indicates quality of cytology; the use of estrogen in postmenopausal women favors its collection. There were difficulties in active search. An immediate repetition of cytology should be considered.


Introdução: O câncer de colo uterino é o terceiro tumor maligno mais frequente na população feminina e a quarta causa de morte de mulheres por câncer no Brasil. A junção escamo-colunar e a zona de transformação concentram 90% das lesões pré-invasoras e invasoras cervicais. Objetivo: Avaliar prevalência de colpocitologias sem células da junção escamo-colunar e a viabilidade de busca ativa. Métodos: Estudo transversal em hospital universitário entre 2017 e 2018. Calculada prevalência de citologias sem células da junção escamo-colunar. Obtida amostra por conveniência, calculada média de idade e relação com a presença da junção escamo-colunar. Realizada busca ativa e colhidas citologias com preparo estrogênico, se indicado. Analisados os prontuários das demais mulheres. Resultados: A prevalência de ausência de células da junção escamo-colunar foi de 28,84%. A média de idade foi 53 anos, sem associação com presença da junção escamo-colunar (p=0,409). Retornaram 76 mulheres e 36 (47,37%) usaram estrogênio. Não identificamos neoplasia intraepitelial cervical graus 2 ou 3, carcinoma microinvasor e câncer. Analisados 134 prontuários, dos quais apenas 36 mulheres (26,87%) concluíram o rastreio. Conclusões: A presença de células da junção escamo-colunar indica qualidade da coleta, e o uso de estrogênio na pós-menopausa favorece sua obtenção. Houve dificuldade de busca ativa. A repetição imediata da citologia deve ser considerada.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Uterine Cervical Neoplasms/diagnosis , Cervical Intraepithelial Neoplasia/diagnosis , Papanicolaou Test/methods , Prevalence , Cross-Sectional Studies , Sensitivity and Specificity , Age Factors , Hospitals, University
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