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Rev. med. Risaralda ; 27(1): 92-95, ene.-jun. 2021. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1280498


Resumen Las malformaciones venosas son lesiones vasculares benignas infrecuentes que se presentan en el útero. Están conformadas por venas anormales, de diferentes tamaños y proporciones, con configuración espongiforme y disposición al azar. En la literatura, han sido previamente reportados algunos casos, usando el término "hemangioma cavernoso", pero según los cambios recientes en la terminología, aprobados por Sociedad Internacional para el Estudio de las Anormalidades Vasculares (ISSVA), se desaconseja el uso de este término y se sugiere el de "Malformación venosa", si se cumplen los hallazgos histopatológicos al momento de hacer el diagnóstico. Presentamos el caso de una mujer de 44 años, con cuadro de hemorragia vaginal anormal y diagnóstico clínico de miomatosis y mioma abortado por el orificio cervical interno, el estudio histopatológico reveló la presencia de una malformación venosa que comprometía el miometrio y endometrio, con formación subsecuente de un pólipo.

Abstract Venous malformations are benign vascular lesions that rarely appear in the uterus. They are made up of abnormal veins, of different sizes and proportions, with spongiform configuration and random disposition. In the literature, some cases have been previously reported, using the term "cavernous hemangioma", but according to recent changes in terminology, approved by the International Society for the Study of Vascular Abnormalities (ISSVA), the use of this term is discouraged, and the diagnosis of Venous malformation is suggested, if the histopathological findings are met. We present the case of a 44-year-old woman, with abnormal vaginal bleeding and a clinical diagnosis of myomatosis and myoma aborted by the internal cervical orifice, in whom the histopathological study revealed the presence of a venous malformation that compromised the myometrium and endometrium, with subsequent formation of a polyp.

Humans , Female , Adult , Uterus , Vascular Malformations , Hemangioma, Cavernous , Uterus/pathology , Vascular System Injuries , Hemangioma , Morphogenesis
Braz. J. Vet. Res. Anim. Sci. (Online) ; 57(1): e158398, 2020. ilus
Article in English | LILACS, VETINDEX | ID: biblio-1122161


Uterine intussusception is a rare condition in bitches. This study aimed to report an unusual case of prolapsed uterine intussusception in a female dog. A 2-year-old American Bully bitch was received with labor history of large fetus requiring manual traction. The animal presented mucosal prolapse through the vulva, unproductive contractions and abdominal discomfort. After partial correction of mucosal prolapse, the dog was referred to ovary-hysterectomy surgery to correct prolapsed mucosa. During the surgical procedure, surgeons observed that the uterine horns were invaginated into the uterine body, rotated, and the tissue was slightly devitalized and congested. As previously described, this condition occurred during the immediate postpartum period. Thus, we suggest that this period can be a facilitator for the establishment of uterine intussusception.(AU)

A intussuscepção uterina é uma condição rara em cadelas. Portanto, este estudo tem por objetivo relatar um caso incomum de intussuscepção uterina prolapsada em fêmea canina. Uma cadela American Bully de dois anos de idade com histórico de parto de feto absoluto grande no qual necessitou de auxílio por tração manual foi apresentada. O animal exibiu um prolapso de mucosa através da vulva, contrações improdutivas e dores abdominais. Após a retração parcial do prolapso de mucosa, a cadela foi encaminhada para a ovário-histerectomia que teve por objetivo, também, corrigir a mucosa prolapsada. Durante o procedimento cirúrgico, foram verificados os cornos uterinos invaginados no corpo uterino, rotacionados, com o tecido levemente desvitalizado e congesto. Assim, como poucos casos encontrados na literatura, esta condição ocorreu durante o puerpério imediato. Dessa forma, sugere-se que este período, embora não seja um fator determinante para o estabelecimento da intussuscepção uterina, pode ser um facilitador no estabelecimento dessa condição.(AU)

Animals , Female , Dogs , Uterus/pathology , Uterine Prolapse/veterinary , Postpartum Period , Intussusception/veterinary
Acta cir. bras ; 33(7): 629-640, July 2018. tab, graf
Article in English | LILACS | ID: biblio-949364


Abstract Purpose: To investigate the effect of melatonin on uterine tissue in the ovariectomized rat model. Methods: Fourty Wistar albino rats were divided into four groups for histologic and immunohistochemical examination. The rats were first numbered randomly and then randomly divided into 4 equal groups: control (group 1), torsion (group 2), torsion+detorsion (group 3) and torsion+detorsion+melatonin (group 4) groups. In addition, four Wistar albino rats were used for western blot analysis in each group. And also, malondialdehyde (MDA) levels were measured biochemically in all rats. Results: The histopathological examination of the uterine tissue in rats ovarectomized showed a degeneration in uterine glands, dilation of blood vessels in the internal layer with a thrombosis and bleeding, abnormal nucleuses and vacuolated cytoplasm above and below the nucleus. In torsion group, the apoptotic cells increased in luminal epithelium and gland cells. In the melatonin group showed that the Bcl2 negative effect on the uterine epithelium and did not lead to apoptotic cells. Conclusion: The increase in vascular endothelial growth factor expression resulted in the rearrangement of endothelial cell growth and the induction of angiogenesis.

Animals , Female , Uterus/drug effects , Uterus/pathology , Estrus/drug effects , Genes, bcl-2/drug effects , Vascular Endothelial Growth Factor A/analysis , Melatonin/pharmacology , Antioxidants/pharmacology , Immunohistochemistry , Ovariectomy , Random Allocation , Blotting, Western , Actins/analysis , Vascular Endothelial Growth Factor A/drug effects , Malondialdehyde/analysis
Acta cir. bras ; 33(6): 499-507, June 2018. tab, graf
Article in English | LILACS | ID: biblio-949358


Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.

Animals , Female , Uterus/drug effects , Capsaicin/pharmacology , Antineoplastic Agents, Alkylating/adverse effects , Curcumin/pharmacology , Cyclophosphamide/adverse effects , Antioxidants/pharmacology , Superoxide Dismutase/analysis , Uterine Diseases/chemically induced , Uterine Diseases/prevention & control , Uterus/pathology , Catalase/analysis , Random Allocation , Reproducibility of Results , Rats, Wistar , Oxidative Stress/drug effects , Glutathione/analysis , Glutathione Peroxidase/analysis , Malondialdehyde/analysis
Acta cir. bras ; 31(8): 557-563, Aug. 2016. tab, graf
Article in English | LILACS | ID: lil-792413


ABSTRACT PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.

Animals , Female , Rats , Ovary/drug effects , Quinolines/pharmacology , Oxidative Stress/drug effects , Polychlorinated Dibenzodioxins/toxicity , Acetates/pharmacology , Antioxidants/pharmacology , Ovary/pathology , Superoxide Dismutase/metabolism , Uterus/pathology , Catalase/metabolism , Random Allocation , Rats, Wistar , Glutathione/metabolism , Ovarian Follicle/drug effects
Acta cir. bras ; 30(11): 756-761, Nov. 2015. graf
Article in English | LILACS | ID: lil-767601


PURPOSE: To investigate the effects of remifentanil as an antioxidant and analyze the histopathologic, biochemical changes in experimental ischemia-reperfusion (I/R) exposed rat uteri. METHODS: Wistar albino rats were assigned to three groups (n = 7). 2h period of ischemia was followed by 1h of reperfusion in the I/R and the I/R-remifentanil groups. After ischemia, no drug was administered in the sham and I/R groups. In the I/R-remifentanil group, remifentanil infusion (2 μg/kg/min) was started in the ischemia period, and continued until the end of reperfusion. After the ischemic and reperfusion period, the ischemic uterine horns were removed surgically for biochemical and histopathologic examination. Tissue damage scores (endometrial epithelial glandular leukocytosis, degeneration, and endometrial stromal changes) were examined. Malondialdehyde levels and catalase, superoxide dismutase enzyme activities in tissue were measured. RESULTS: We found significantly lower epithelial leukocytosis and cell degeneration in the I/R-remifentanil group (p<0.05). Remifentanil administration significantly decreased concentrations of malondialdehyde, and increased catalase and superoxide dismutase enzyme activities (p<0.05). CONCLUSION: Remifentanil appears to protect the uterine tissue against ischemia-reperfusion and can be used safely in uterus transplantation.

Animals , Female , Analgesics, Opioid/pharmacology , Ischemia/prevention & control , Piperidines/pharmacology , Reperfusion Injury/prevention & control , Uterus/blood supply , Antioxidants/pharmacology , Catalase/drug effects , Ischemia/pathology , Malondialdehyde/analysis , Random Allocation , Rats, Wistar , Reproducibility of Results , Reperfusion Injury/pathology , Superoxide Dismutase/drug effects , Time Factors , Uterus/pathology
Rev. Assoc. Med. Bras. (1992) ; 61(5): 446-451, Sept.-Oct. 2015. tab
Article in English | LILACS | ID: lil-766253


Summary Objective: to describe the initial results of a laparoscopic single port access hysterectomy and also to evaluate the feasibility and safety of this access. Methods: a prospective study was performed at a tertiary university medical center (Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo) between March 2013 and June 2014. A total of 20 women, referred for hysterectomy due to benign uterine disease, were included in the study after they had signed an informed consent. Outcome measures, including operating time, blood loss, rate of complications, febrile morbidity, visual analogical pain score and length of hospital stay were registered. Results: mean patient age and body mass index (BMI) were 47.8 years and 27.15 kg/m2, respectively. Mean operating time was 165.5 min. Blood loss was minimal, with no blood transfusion. All procedures but one were successfully performed via a single incision and no post-operative complications occurred. We experienced one conversion to multiport laparoscopic hysterectomy due to extensive pelvic adhesions. There was no conversion to “open” total abdominal hysterectomy. None of the patients required narcotics or NSAD post-operatively. Conclusion: single-port hysterectomy is a feasible and safe technique, with no major complications.

Resumo Objetivo: descrever os resultados iniciais da histerectomia laparoscópica realizada através de punção umbilical única, além de avaliar a praticabilidade e segurança dessa via de acesso cirúrgico. Métodos: este estudo prospectivo foi realizado em um hospital universitário terciário (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brasil) entre março de 2013 e junho de 2014. Um total de 20 mulheres candidatas à histerectomia por doenças uterinas benignas foram incluídas neste estudo, após terem assinado termo de consentimento informado. Foram analisados os resultados cirúrgicos, incluindo tempo de cirurgia, perda sanguínea, complicações, morbidade febril, dor pós-operatória e tempo de permanência hospitalar. Resultados: a média de idade e índice de massa corpórea das pacientes foi de 47.8 anos e 27.15 kg/m2, respectivamente. O tempo cirúrgico médio foi de 165.5 minutos. A perda sanguínea foi mínima, sem necessidade de transfusão em nenhuma paciente. Todos os procedimentos foram realizados satisfatoriamente, apenas um caso necessitou de conversão cirúrgica para laparoscopia convencional (com 3 punções abdominais) por múltiplas aderências, porém sem necessidade de realização de laparotomia e não houveram complicações pós-cirúrgicas. Nenhuma paciente deste estudo solicitou administração de medicação analgésica adicional no pós-operatório. Conclusão: a histerectomia com acesso único umbilical é um procedimento factível e seguro, sem maiores complicações.

Adult , Aged , Female , Humans , Middle Aged , Hysterectomy/methods , Laparoscopy/methods , Leiomyoma/surgery , Uterine Neoplasms/surgery , Blood Loss, Surgical , Hemoglobins/analysis , Hysterectomy/adverse effects , Hysterectomy/instrumentation , Length of Stay , Laparoscopy/adverse effects , Laparoscopy/instrumentation , Operative Time , Organ Size , Prospective Studies , Pain, Postoperative/classification , Treatment Outcome , Uterus/pathology
Braz. j. microbiol ; 46(1): 279-283, 05/2015. graf
Article in English | LILACS | ID: lil-748263


Bovine Herpesvirus 4 (BoHV-4) is a member of Gammaherpesvirinae sub-family and belongs to genus Rhadinovirus. This virus has been associated with different clinical manifestations and research activity has put forward a strong correlation among virus infection, postpartum metritis, and abortion. The goal of this work was to characterize a virus strain isolate from a cow’s uterine outflow. From swabs drawn of uterine secretion, a virus strain was isolated and characterized by its cytopathology, morphology, and molecular biology approaches. In culture there was CPE development, characterized mainly by long strands with several small balloons along them, radiated from infected cells. Electron microscopy analysis revealed virus particles that had icosahedrical capsid symmetry surrounded by a loose envelope, typical of a herpesvirus. A 2,571 bp PCR product after HindIII digestion generated four fragments, whose base pair composition were 403, 420, 535, and 1,125 bp. Restriction enzymes HindIII and BamHI generated the expected diagnostic bands as well as a 2,350 bp hypermolar fragment as a result of BamHI treatment to demonstrate that agent was a bovine herpesvirus 4, appertaining to DN-599 group.

Animals , Cattle , Female , Cattle Diseases/virology , Herpesviridae Infections/veterinary , /classification , /isolation & purification , Tumor Virus Infections/veterinary , Brazil , Cytopathogenic Effect, Viral , DNA, Viral/genetics , DNA, Viral/metabolism , Exudates and Transudates/virology , Herpesviridae Infections/virology , /genetics , Microscopy, Electron, Transmission , Polymorphism, Restriction Fragment Length , Tumor Virus Infections/virology , Uterus/pathology , Uterus/virology , Virus Cultivation , Virion/ultrastructure
Article in English | IMSEAR | ID: sea-159464


Fibroids are most common benign tumors of the uterus, mostly situated in the body of the uterus. Rarely, they arise from extra-uterine sites with broad ligament fibroids being uncommon. Although by clinical examination and newer imaging modalities, we can easily know about size, number, and origin of these tumors and any anatomical distortion of surrounding vital organs, but some time it is very difficult to differentiate pre-operatively between large broad ligament leiomyomas and ovarian/adnexal pathology specially if cystic degeneration or necrosis is present in leiomyoma. We report four patients with broad ligament fibroids to emphasize the importance of their location, the diagnostic difficulties, and surgical complications they can pose.

Broad Ligament/pathology , Female , Humans , Laparotomy/methods , Laparotomy/statistics & numerical data , Leiomyoma/diagnosis , Leiomyoma/epidemiology , Leiomyoma/surgery , Middle Aged , Ureter/injuries , Ureter/pathology , Uterus/pathology
Reprod. clim ; 30(3): 148-151, 2015. ilus
Article in English | LILACS | ID: biblio-973037


Dermoid cysts of the uterus are extremely rare. A case of an asymptomatic dermoid cyst in the previous caesarean section scar is reported in a 39-year-old woman who presented for pre-conception evaluation. A nodular lesion of the uterus was identified through transvaginal ultrasound examination and magnetic resonance imaging and its characteristics are described. The first treatment option was hysteroscopic resection but complete removal could not be achieved. Surgical excision is likely to be the definitive treatment and a hysterectomy will be proposed to the patient after she completes her family. Our literature review indicates that this is the first case of a dermoid cyst located in the previous caesarean section scar.

Cistos dermoides do útero são extremamente raros. Este é um relato de caso de cisto dermoide assintomático na cicatriz de cesariana preexistente em mulher com 39 anos que se apresentou para avaliação pré-concepcional. Foi identificada uma lesão nodular por exame ultrassonográfico transvaginal e ressonância magnética; descrevemos suas características. A primeira opção terapêutica foi a ressecção histeroscópica, mas não foi possível fazer uma remoção completa. É provável que a excisão cirúrgica seja o tratamento definitivo; será proposta uma histerectomia à paciente, depois de ter completado sua família. Nossa revisão da literatura indica que este é o primeiro caso de cisto dermoide localizado em uma cicatriz de cesariana preexistente.

Female , Humans , Adult , Dermoid Cyst/diagnosis , Dermoid Cyst/surgery , Uterus/pathology , Hysteroscopy/methods , Cicatrix/complications , Cesarean Section/adverse effects , Hysterectomy/methods
Article in English | IMSEAR | ID: sea-157600


Vaginal hysterectomy was the first minimally invasive surgical approach for benign gynecologic conditions, a number of other approaches for hysterectomy have been introduced, yet when compared with vaginal hysterectomy these approaches do not offer significant benefits for similar indications. Objectives : (1) To know the benign gynecological conditions that can be treated by vaginal hysterectomy. (2) To find out the operative difficulties of vaginal hysterectomy done in non-prolapsed uterus. (3) To know the morbidity and mortality of vaginal hysterectomy. Methodology : This is a prospective study conducted at our Hospital from 1st December 2010 to 30th Nov. 2011. Hundred consecutive cases of non-descent vaginal hysterectomy for benign pathology of uterus were studied. Results : In our study maximum hysterectomies were done in the age group 41-50 (49%) followed by 31- 40 (40%) least were in age more than 50 years. Mean parity of the cases undergoing hysterectomy were 2.47. In 77% patients, complaints were menorrhagia. The maximum hysterectomies, 41% for fibroid uterus were done, followed by 39% for DUB. One patient had intraoperative bladder injury. Mean operating time for the hysterectomies was 53.21 minutes. No mortality was seen, 12% post-operative complications were present. The mean post-operative stay in the hospital was 5.95 days. Conclusion : Vaginal hysterectomy is both feasible and optimal for many patients who long have been considered inappropriate candidates for vaginal hysterectomy. Many more hysterectomies should be carried out vaginally without resorting to abdominal or laparoscopic approach for benign conditions of the uterus.

Adult , Female , Humans , Hysterectomy, Vaginal/methods , Hysterectomy, Vaginal/statistics & numerical data , Leiomyoma/epidemiology , Leiomyoma/pathology , Leiomyoma/surgery , Middle Aged , Uterus/pathology , Uterus/surgery
Clinics ; 69(3): 185-189, 3/2014. tab
Article in English | LILACS | ID: lil-703605


OBJECTIVE: Minimally invasive methods are used as alternatives to treat leiomyomas and include uterine artery embolization, which has emerged as a safe, effective method. This study aims to evaluate the magnetic resonance imaging predictors for a reduction in leiomyoma volume in patients undergoing uterine artery embolization. METHODS: This prospective longitudinal study was performed at a university hospital. We followed 50 symptomatic premenopausal women with uterine leiomyomas who underwent uterine artery embolization. We examined 179 leiomyomas among these patients. Magnetic resonance imaging was performed one month before and six months after uterine artery embolization. Two radiologists who specialized in abdominal imaging independently interpreted the images. Main Outcome Measures: The magnetic resonance imaging parameters were the uterus and leiomyomas volumes, their localizations, contrast perfusion pattern and node-to-muscle ratio. RESULTS: Six months after treatment, the average uterine volume reduction was 38.91%, and the leiomyomas were reduced by 55.23%. When the leiomyomas were submucosal and/or had a higher node-to-muscle ratio in the T2 images, the volume reduction was even greater (greater than 50%). Other parameters showed no association. CONCLUSIONS: We conclude that symptomatic uterine leiomyomas in patients undergoing uterine artery embolization exhibit volume reductions greater than 50% by magnetic resonance imaging when the leiomyomas are submucosal and/or had a high node-to-muscle ratio in the T2 images. .

Adult , Female , Humans , Leiomyoma/therapy , Magnetic Resonance Imaging/methods , Pelvic Neoplasms/therapy , Uterine Artery Embolization/methods , Uterine Neoplasms/therapy , Leiomyoma/pathology , Multivariate Analysis , Observer Variation , Predictive Value of Tests , Prospective Studies , Pelvic Neoplasms/pathology , Time Factors , Treatment Outcome , Tumor Burden , Uterine Neoplasms/pathology , Uterus/blood supply , Uterus/pathology
Arq. bras. med. vet. zootec ; 65(5): 1281-1285, out. 2013. ilus, graf, tab
Article in English | LILACS | ID: lil-689742


The present report describes the clinical and pathological findings related to diffuse heterotopic hairs associated with pseudo-placentational endometrial hyperplasia in a canine uterus. Macroscopically, the uterus was intensely enlarged and thicker, and the endometrial surface was irregular and covered with black hairs similar to the hairs of the bitch. Histologically, heterotopic hairs associated with pseudo-placentational endometrial hyperplasia were observed.

O presente relato descreve os achados clínicos e patológicos de uma heterotopia de pelos difusa associada com hiperplasia endometrial pseudo-placentacional em um útero de uma cadela. Macroscopicamente, o útero estava intensamente aumentado de volume e espesso, a superfície do endométrio estava irregular e recoberta com pelos pretos semelhantes aos pelos da cadela. Histologicamente, heterotopia de pelos associada com hiperplasia endometrial pseudoplacentacional foi observada.

Animals , Female , Dogs , Endometrium/growth & development , Endometrium/pathology , Uterus/growth & development , Uterus/pathology
Indian J Exp Biol ; 2013 Mar; 51(3): 235-240
Article in English | IMSEAR | ID: sea-147587


The snake shed skin though considered as biological waste products have been mentioned in folk and traditional medicine for treatment of ailments like skin disorders, parturition problems etc. Shedded skin extract (5, sc) did not produce any change in the estrous cycle of normal cycling female mice. However in 10, sc dose, the extract caused a temporary cessation of the estrous cycle at diestrous phase in normal cycling female mice for 10 days. SSAE (10, sc) caused a significant change in the level of LH, FSH, progesterone, estradiol, IL-1β, IL-6 and TNF-α. Histopathology of uterus and ovary showed structural disorientation in both. The results substantiate the influence of snake shed skin in mice reproductive cycle.

Animals , Cytokines/metabolism , Elapidae , Estradiol/metabolism , Estrous Cycle/drug effects , Estrous Cycle/metabolism , Female , Fertility/drug effects , Gene Expression Regulation/drug effects , Hormones/metabolism , Mice , Ovary/metabolism , Ovary/pathology , Progesterone/metabolism , Reproduction , Skin/chemistry , Uterus/metabolism , Uterus/pathology
Arq. Inst. Biol ; 80(1): 27-34, jan.-mar.2013. tab, ilus
Article in Portuguese | LILACS | ID: lil-784837


Este trabalho foi realizado em suínos abatidos no Município de Patos, Estado da Paraíba, Brasil,com o objetivo de determinar a frequência de anticorpos anti-Leptospira spp., comparando os achados sorológicos com exames histopatológicos de rim, fígado, ovário e útero. A soroaglutinação microscópica foi realizada em 126 animais. Os exames histopatológicos realizados em cortes de fígado, rim, ovário e útero, corados pela hematoxilina-eosina (HE), foram realizados em 20 animaisescolhidos aleatoriamente, sendo 10 do grupo com títulos ≥ 100 e 10 do grupo com títulos < 100. Paralelamente, foi realizada pesquisa direta de leptospiras pela técnica de Warthin-Starry em amostras de rim de todos os animais soropositivos e nos 10 animais soronegativos submetidos à HE. Dos 126 animais examinados, 18 (14,6%) foram soropositivos, com predominância de reações para o sorovar Autumnalis (11 animais; 8,73%). Quatro animais soropositivos e dois animais soronegativosapresentaram infiltrado inflamatório e necrose de graus variados em um dos rins e no fígado. Os ovários e úteros examinados não apresentaram lesões. A pesquisa direta de leptospiras pela técnica de Warthin-Starry não revelou animais positivos em nenhuma amostra testada. Em face da soropositividade encontrada (14,6%), sugere-se a importância da conscientização por parte dos produtores acerca da implantação de medidas de prevenção adequadas com o objetivo de impedir, ou pelo menos diminuir, a disseminação das leptospiras em suínos e, consequentemente, bloquear a possível transmissão do agente para os seres humanos...

Interrelation between frequency of anti-leptospira spp. Antibodies and findings of histopathological examinations (hematoxylin-eosin and warthin-starry) in pigs slaughtered in the semiarid of paraiba state, northeastern brazil. This work was conducted in slaughtered pigs in Patos County, Paraiba State, Brazil, with the aim to determine the frequency of anti-leptospira antibodies and to compare the serological findings with the histopathological findings of kidney, liver, ovary and uterus. The microscopic agglutination test (MAT) was performed on 126 animals. The histopathological examination performed in sections of livers, kidneys, ovaries and uteruses stained with hematoxylin-eosin (HE) was conducted in 20 randomly chosen animals (10 from group with serological titer ≥ 100 and 10 from group < 100). Parallel to this, a direct search for leptospires was carried out by Warthin-Starry technique in kidney samples from all seropositive animals and in the 10 seronegative animals submitted to HE. In the 126 animals examined, 18 (14.6%) were seropositive, with prevalence of reactions to Autumnalis serovar (11 animals; 8.73%). Four seropositive and two seronegative animals showed different degrees of inflammatory infiltrate and necrosis in liver or kidney. The ovaries and uterus no showed lesions. Direct analysis of leptospires by the Warthin-Starry technique did not reveal positive animals in any sample tested. The rate of seropositivity found (14.6%) suggests the importance of awareness by producers about the implementation of preventive measures aimed at preventing, or at least reducing the spread of leptospiras in pigs and thereby blocking the possible transmission of the agent to humans...

Animals , Antibodies/analysis , Leptospira/pathogenicity , Necrosis , Liver/pathology , Ovary/pathology , Kidney/pathology , Swine/classification , Uterus/pathology
IJFS-International Journal of Fertility and Sterility. 2013; 7 (1): 1-6
in English | IMEMR | ID: emr-142772


Structural intrauterine abnormalities are an important cause of infertility, recurrent pregnancy loss and bleeding or pain associated with a poor reproductive outcome. Various diagnostic methods have been applied to detect these lesions such as hysterosalpingography, hysteroscopy and sonohysterography. More recently, three-dimensional extended imaging [3DXI] provides the ability to obtain sequential sections of acquired volume scans in A, B and C planes. Here, we briefly discuss the technique of saline infusion sonography, followed by a review of sonohysterographic characteristics of intracavitary pathologies with more focus on some definitions and measurements

Uterus/pathology , Uterus/diagnostic imaging , Hysteroscopy/methods , Endometrium/diagnostic imaging
Yonsei Medical Journal ; : 209-214, 2013.
Article in English | WPRIM | ID: wpr-66219


PURPOSE: Venous air embolism (VAE) is characterized by the entrainment of air or exogenous gases from broken venous vasculature into the central venous system. No study exists regarding the effect of patient positioning on the incidence of VAE during abdominal myomectomy. The purpose of this study was to assess the incidence and grade of VAE during abdominal myomectomy in the supine position in comparison to those in the head-up tilt position using transesophageal echocardiography. MATERIALS AND METHODS: In this study, 84 female patients of American Society of Anesthesiologist physical status I or II who were scheduled for myomectomy under general anesthesia were included. Patients were randomly divided into two groups: supine group and head-up tilt group. Transesophageal echocardiography images were videotaped throughout the surgery. The tapes were then reviewed for VAE grading. RESULTS: In the supine group, 10% of the patients showed no VAE. Moreover, 10% of the patients were classified as grade I VAE, while 50% were categorized as grade II, 22.5% as grade III, and 7.5% as grade IV. In the head-up tilt group, no VAE was detected in 43.2% of the patients. In addition, 18.2% of the patients were classified as grade I VAE, 31.8% as grade II, and 6.8% as grade III; no patients showed grade IV. VAE grade in the head-up tilt group was significantly lower than that in the supine group (p<0.001). CONCLUSION: The incidence and grade of VAE in the head-up tilt group were significantly lower than those in the supine group during abdominal myomectomy.

Abdomen/pathology , Adult , Echocardiography, Transesophageal , Embolism, Air/epidemiology , Female , Humans , Incidence , Middle Aged , Myoma/pathology , Posture , Supine Position , Uterine Myomectomy/adverse effects , Uterus/pathology , Veins/diagnostic imaging
Indian J Pathol Microbiol ; 2012 Jul-Sept 55(3): 377-378
Article in English | IMSEAR | ID: sea-142273


Schistosomiasis still represents a major threat to women's health in many developing countries. The frequency in developed countries is increasing among immigrants and tourists who have a history of freshwater exposure in endemic areas. This is a case of 43-year-old immunocompetent Egyptian woman presented by abnormal vaginal bleeding. The gynecological examination revealed an endocervical polyp measuring 3 x 2 x 1 cm. Polypectomy was done. Histopathological examination revealed several granulomas containing viable eggs of Schistosoma hematobium. Schistosomiasis is rarely presented with endocervical polyp. In developing countries, schistosomiasis may be considered in differential diagnosis of patient with endocervical polyp.

Adult , Animals , Egypt , Female , Histocytochemistry , Humans , Polyps/pathology , Polyps/surgery , Schistosoma haematobium/isolation & purification , Schistosomiasis haematobia/diagnosis , Schistosomiasis haematobia/pathology , Schistosomiasis haematobia/surgery , Uterine Hemorrhage/etiology , Uterus/pathology , Uterus/surgery
IJFS-International Journal of Fertility and Sterility. 2012; 6 (1): 27-30
in English | IMEMR | ID: emr-155432


This study was designed to evaluate the incidence of uterine pathologies in infertile women with a history of two implantation failures after in vitro fertilization [IVF] and estimate the effect of hysteroscopic correction on achieving a pregnancy in these patients. The retrospective study population included 238 infertile women attended the outpatient infertility clinic between November 2007 and December 2008. Patients with at least two previous IVF failures were eligible for this study. All patients had normal findings on hysterosalpingography performed prior their first attempt for IVF. Standard transvaginal ultrasonography and diagnostic hysteroscopy were performed in patients before the subsequent IVF attempt. Out of 238 patients with previous IVF failure who underwent hysteroscopic evaluation, 158 patients [66.4%] showed normal uterine cavity. Abnormal cavity was found in 80 patients [33.6%]. We found polyp as the most common abnormality [19.7%] in the patients with previous history of IVF failure. The pregnancy rate was similar between IVF failure patients who treated by hysteroscopy for a detected uterine abnormality [24.6%] and similar patients with normal uterine cavity [21.2%] in hysteroscopic examinations. The intrauterine lesions diagnosed by hysteroscopy in patients with previous IVF failure ranges from 0.8%-19.7%. Correction of abnormalities such as myoma and polyp showed good outcome, similar to that achieved in patients with a normal hysteroscopy

Humans , Female , Adult , Middle Aged , Hysteroscopy , Infertility, Female , Embryo Implantation , Uterus/pathology , Treatment Failure , Retrospective Studies