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1.
Arch. latinoam. nutr ; 71(1): 5-12, mar. 2021. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1283237

ABSTRACT

La vitamina D es esencial para el funcionamiento del organismo. Su deficiencia puede estar asociada tanto a patologías óseas, como a otras afecciones sistémicas. La prevalencia de la hipovitaminosis está aumentando, en todas las edades, incluidos niños y adolescentes. El objetivo del presente estudio fue evaluar los niveles sanguíneos de vitamina D en niñas colombianas, analizando también la dieta, la actividad física y la exposición solar. Se realizó un estudio descriptivo transversal con 52 niñas sanas prepúberes de Pasto (Colombia), entre 7 y 10 años. Se analizaron los niveles de albúmina, calcio, fósforo, magnesio, calcitriol (1,25 dihidroxicolecalciferol) y calcidiol (25 hidroxicolecalciferol). Se realizaron encuestas sobre hábitos alimentarios, actividad física y exposición solar. El 51,1% de las niñas evaluadas presentó insuficiencia de 25-OH-VITD y el 40% presentó deficiencia (< 20 ng/mL). Ninguna niña se encontraba en desnutrición u obesidad, el 10% se encontraba en riesgo de bajo peso (IMC ≤ -1DE y > -2DE), el 4 % presentaba sobrepeso (≥ +1DE y < +2DE), y el 34 % se encontraban en riesgo de talla baja (T/E: -1 y -2 DE). La ingesta media de calorías/día fue inferior a las recomendadas. Se observó una ingesta deficiente de vitamina D, calcio y magnesio (p > 0,05), así como de fibra (p > 0,05). Se pone de manifiesto una deficiencia de vitamina D en las niñas evaluadas a pesar de tener una actividad física y una exposición solar adecuadas. Además, se observan ingestas deficientes de fibra, calcio, magnesio y vitamina D. Habría por tanto que asegurar la ingesta e incluso suplementar para evitar problemas de salud en la edad adulta(AU)


Vitamin D is essential for the body to function. Its deficiency can be associated with bone pathologies as well as other systemic conditions. The prevalence of hypovitaminosisis increasing, in all ages, including children and adolescents. The objective of this study was to evaluate blood levels of vitamin D in Colombian girls, also analyzing diet, physical activity and sun exposure. A descriptive cross-sectional study was carried out with 52 healthy prepubertal girls from Pasto (Colombia), between 7 and 10 yearsold. The levels of albumin, calcium, phosphorus, magnesium, calcitriol (1.25 dihydroxycholecalciferol) and calcidiol (25 hydroxycholecalciferol) were analyzed. Surveys were conducted one a ting habits, physicalactivity and sun exposure. 51.1% of the girls evaluated presented 25-OH-VITD insufficiency and 40% presented deficiency (<20 ng / mL). None of the girls were under nourished or obese, 10% were at risk of low weight (BMI ≤ -1SD and> -2SD), 4% were overweight (≥ + 1DE and <+ 2DE), and 34% were they were at risk of short stature (T / E: -1 and -2 SD). The average calorie intake / day was lower than recommended. A deficient intake of vitamin D, calcium and magnesium (p> 0.05), as well as fiber (p> 0.05) was observed. A vitamin D deficiency is evident in the girls evaluated despite adequate physical activity and sun exposure. In addition, deficient intakes of fiber, calcium, magnesium and vitamin D are observed. Therefore, it would be necessary to ensure the intake and even supplement to avoid health problems in adulthood(AU)


Subject(s)
Humans , Female , Child , Sunlight , Vitamin D Deficiency/blood , Exercise , Diet , Vitamin D Deficiency/epidemiology , Cross-Sectional Studies , Colombia/epidemiology , Eating
2.
Gac. méd. Méx ; 156(6): 519-525, nov.-dic. 2020. tab
Article in Spanish | LILACS | ID: biblio-1249961

ABSTRACT

Resumen Introducción: La relación entre 25-OH-vitamina D y el sistema inmune en pacientes con enfermedad renal crónica es objeto de atención. Objetivos: Evaluar la prevalencia de la deficiencia de vitamina D en pacientes en hemodiálisis e investigar la asociación entre la vitamina D y proteína C reactiva ultrasensible (PCRus), índice neutrófilo/linfocito (INL) e índice plaqueta/linfocito (IPL). Método: Estudio transversal de 80 pacientes en hemodiálisis, divididos en dos grupos: un nivel sérico de 25-OH-vitamina D < 20 ng/mL se consideró como deficiencia de vitamina D y ≥ 20 ng/mL, como normal. Con el análisis de correlación de Spearman se definió la relación entre los parámetros. Resultados: 40 % de los pacientes presentó deficiencia de vitamina D. Hubo diferencias significativas entre los grupos en PCRus (p = 0.047), INL (p = 0.039), IPL (p = 0.042) y tratamiento con análogos de vitamina D (p = 0.022). La vitamina D tuvo una correlación negativa significativa con PCRus (p = 0.026), INL (p = 0.013) e IPL (p = 0.022). Conclusiones: La deficiencia de vitamina D fue de 40 %. Los niveles de PCRus, INL e IPL fueron significativamente más altos ante deficiencia de vitamina D. Se encontró correlación inversa significativa entre vitamina D y PCRus, INL e IPL.


Abstract Introduction: The relationship between 25-OH-vitamin D and the immune system in patients with chronic kidney disease is a subject of attention. Objectives: To assess the prevalence of vitamin D deficiency in patients on hemodialysis and to investigate the association between vitamin D, ultra-sensitive C-reactive protein (US-CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Method: Cross-sectional study of 80 patients on hemodialysis, divided into two groups: a serum 25-OH-vitamin D level < 20 ng/mL was considered to be vitamin D deficiency and a serum level ≥ 20 ng/mL was regarded as normal. The relationship between the parameters was defined with Spearman’s correlation analysis. Results: 40 % of the patients had vitamin D deficiency. There were significant differences between groups in US-CRP (p = 0.047), NLR (p = 0.039), PLR (p = 0.042) and treatment with vitamin D analogues (p = 0.022). Vitamin D had a significant negative correlation with US-CRP (p = 0.026), NLR (p = 0.013) and PLR (p = 0.022). Conclusions: The prevalence of vitamin D deficiency was 40 %. The values of US-CRP, NLR and PLR were significantly higher in the presence of vitamin D deficiency. A significant inverse correlation was found between vitamin D levels and US-CRP, NLR and PLR.


Subject(s)
Humans , Male , Female , Aged , Vitamin D/blood , Vitamin D Deficiency/blood , Vitamin D Deficiency/epidemiology , Renal Dialysis , Inflammation Mediators/blood , Renal Insufficiency, Chronic/blood , Blood Platelets/cytology , C-Reactive Protein/analysis , Lymphocytes/cytology , Biomarkers/blood , Prevalence , Cross-Sectional Studies , Renal Insufficiency, Chronic/therapy , Neutrophils/cytology
3.
Rev. chil. pediatr ; 91(5): 684-690, oct. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1144266

ABSTRACT

INTRODUCCIÓN: El primer año de vida es un periodo de riesgo de deficiencia de vitamina D (VD). La administración de 400 UI diarias de VD no tiene una adherencia del 100%, en cambio dosis únicas de 100.000 UI de VD oral son seguras en recién nacidos. OBJETIVO: Comparar el efecto de la suplementación oral de VD en dosis única de 100.000 UI al mes de edad vs dosis diarias de 400 UI sobre las concentraciones séricas de VD, a los 6 meses de vida. SUJETOS Y MÉTODOS: Ensayo clínico aleatorizado, sin enmascaramiento. Se incluyeron 84 lactantes sanos de 1 mes de vida, asignados al azar al grupo de estudio (GE) que recibió una dosis única de VD de 100.000 UI oral o al grupo control (GC), que recibió dosis diarias de VD de 400 UI oral del 1er al 6to mes de vida. A los 6 meses de edad se determinó la concentración sérica de VD. RESULTADOS: 65 lactantes terminaron el estudio, 36 en GE y 29 en GC. No se encontró deficiencia de VD. La insuficiencia de VD fue de 5,5% y 6,8% en el GE y GC, respectivamente. La concentración sérica de VD a los 6 meses de vida, fue de 38,8 ± 5,2 ng/ml y 39,7 ± 6,3 ng/ml para GE y GC, respectivamente (NS). CONCLUSIONES: La suplementación con 100.000 UI de VD única al mes de edad logra concentraciones séricas de VD a los 6 meses de vida, similares a dosis diarias de 400 UI de VD, del 1er al 6to mes.


INTRODUCTION: Infants are a group at risk of vitamin D (VD) deficiency. The administration of 400 IU of VD per day during the first year of life does not achieve 100% adherence. A single dose of 100,000 IU of oral VD is safe in newborns. OBJECTIVE: To compare the effect of oral administration of VD between a single dose of 100,000 IU at one month of age vs daily doses of 400 IU on serum concentrations of VD, at 6 months of age. SUBJECTS AND METHOD: Randomized clinical trial, without masking. 84 healthy infants were included at 1 month of age, randomized to the study group (SG) receiving a single oral dose of 100,000 IU or to the control group (CG), who received daily oral doses of VD of 400 IU from the 1st to the 6th month of life. At 6 months of life, the serum concentration of VD was determined. RESULTS: 65 infants completed the study, 36 in SG and 29 in CG. No VD deficiency was found. VD insufficient was 5.5% and 6.8% in the SG and CG, respectively. The serum concentration of VD at six months of age was 38.8 ± 5.2 ng/ml and 39.7 ± 6.3 ng/ml for the SG and CG, respectively (NS). CONCLUSIONS: Supplementation of 100,000 IU of VD at one month age achieves serum concentrations of VD at 6 months of life similar to the administration of daily doses of 400 IU of VD from the 1st to the 6th month.


Subject(s)
Humans , Male , Female , Infant , Vitamin D/administration & dosage , Vitamin D Deficiency/prevention & control , Vitamins/administration & dosage , Dietary Supplements , Vitamin D/analogs & derivatives , Vitamin D/blood , Vitamin D/therapeutic use , Vitamin D Deficiency/diagnosis , Vitamin D Deficiency/blood , Vitamins/therapeutic use , Drug Administration Schedule , Biomarkers/blood , Nutritional Status , Administration, Oral , Follow-Up Studies , Treatment Outcome , Dose-Response Relationship, Drug
4.
Rev. Assoc. Med. Bras. (1992) ; 66(3): 268-274, Mar. 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1136203

ABSTRACT

SUMMARY OBJECTIVE To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD). METHODS A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0.90 or with arterial revascularization. Vitamin D serum level was categorized as sufficient (≥30 ng/mL), insufficient (>20 to 29 ng/mL), and deficient (<20 ng/mL). Prevalence ratios (RP) were calculated through Poisson regression. RESULTS The prevalence of PAD was 50.7% (95% CI 42-59). After adjustment for potential PAD risk factors, RP were 1.08 (95% CI 0.66-1.76) for insufficient serum level and 1.57 (95% CI 0.96-2.57) for deficient vitamin D serum level; (p for trend = 0.020). CONCLUSION Vitamin D serum levels showed an inverse and significant dose-response relationship with PAD.


RESUMO OBJETIVO Investigar a associação entre níveis séricos de vitamina D e doença arterial obstrutiva periférica (DAOP). MÉTODOS Estudo transversal, com amostra consecutiva de 133 indivíduos. Foram considerados com DAOP pacientes com índice tornozelo braquial ≤ 0,90 ou com revascularização arterial. O nível sérico de vitamina D foi classificado em: suficiente (≥30 ng/mL), insuficiente (>20 a 29 ng/mL) e deficiente (<20 ng/mL). Razões de Prevalência (RP) foram calculadas por meio de regressão de Poisson. RESULTADOS A prevalência de DAOP foi de 50,7% (IC95% 42-59). Após ajuste para potenciais fatores de risco para DAOP, as RP foram de 1,08 (IC95% 0,66-1,76) para nível sérico insuficiente e de 1,57 (IC95% 0,96-2,57) para o nível sérico deficiente de vitamina D; (p para tendência = 0,020). CONCLUSÃO O nível sérico de vitamina D mostrou uma relação dose/resposta inversa e significativa com DAOP.


Subject(s)
Humans , Male , Female , Adult , Vitamin D/blood , Vitamin D Deficiency/complications , Peripheral Arterial Disease/etiology , Peripheral Arterial Disease/blood , Vitamin D/therapeutic use , Vitamin D Deficiency/blood , Brazil/epidemiology , Prevalence , Cross-Sectional Studies , Risk Factors , Ankle Brachial Index , Peripheral Arterial Disease/epidemiology , Middle Aged
5.
Arq. neuropsiquiatr ; 77(12): 848-854, Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1055204

ABSTRACT

ABSTRACT Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D receptors (VDR) and to evaluate cardiac dysautonomia in MS patients due to bidirectional interaction between vitamin D and the autonomic nervous system. Methods: The current cross-sectional study was conducted on 26 patients with relapsing-remitting MS and on 24 healthy controls. Twenty-four-hour ambulatory blood pressure variability (BPV) was calculated and the participants were evaluated for orthostatic hypotension and supine hypertension. Serum levels of vitamin D, VDBP and VDR were measured. Results: The mean serum vitamin D level was significantly lower in MS patients than in controls (p = 0.044); however there was no significant difference in terms of VDR and VDBP levels between the groups. Supine hypertension and orthostatic hypotension were significant and the 24-hour systolic BPV was significantly decreased in patients with MS (p < 0.05) compared to controls. No correlation was found between vitamin D, VDBP and VDR with supine hypertension, orthostatic hypotension and systolic BPV values (p > 0.05). Also, there was a negative correlation between VDBP and the EDSS (p = 0.039, r = −0.406). Conclusion: There was no correlation between orthostatic hypotension, supine hypertension and systolic BPV values and serum vitamin D, VDBP and VDR in MS patients. Future prospective studies with large number of patients may help us to better understand the relationship between vitamin D and the autonomic nervous system.


RESUMO A vitamina D é um hormônio esteroide pleiotrópico que modula o equilíbrio autonômico. Sua deficiência tem sido descrita como fator de risco ambiental para esclerose múltipla (EM). O objetivo deste estudo foi investigar os níveis séricos de vitamina D, proteína de ligação à vitamina D (VDBP) e receptor de vitamina D (VDR) e avaliar a disautonomia cardíaca em pacientes com EM devida à interação bidirecional entre vitamina D e sistema nervoso autônomo. Métodos: O presente estudo transversal foi realizado em 26 pacientes com EM remitente-recorrente e em 24 controles saudáveis. A variabilidade da pressão arterial ambulatorial (BPV) por 24 horas foi calculada e os participantes foram avaliados quanto à hipotensão ortostática e hipertensão supina. Os níveis séricos de vitamina D, VDBP e VDR foram medidos. Resultados: O nível sérico médio de vitamina D foi significativamente menor nos pacientes com EM do que nos controles (p = 0,044); no entanto, não houve diferença significativa em termos de níveis de VDR e VDBP entre os grupos. Hipertensão supina e hipotensão ortostática foram significativas e a BPV sistólica de 24 horas diminuiu significativamente em pacientes com EM (p < 0,05) em comparação aos controles. Não foi encontrada correlação entre vitamina D, VDBP e VDR com hipertensão supina, hipotensão ortostática e BPV sistólica (p > 0,05). Também houve correlação negativa entre VDBP e EDSS (p = 0,039, r = −0,406). Conclusão: Não houve correlação entre hipotensão ortostática, hipertensão supina e valores de BPV sistólica e vitamina D sérica, VDBP e VDR em pacientes com EM. Futuros estudos prospectivos com grande número de pacientes podem nos ajudar a entender melhor a relação entre vitamina D e sistema nervoso autônomo.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Autonomic Nervous System Diseases/blood , Vitamin D/blood , Vitamin D-Binding Protein/blood , Receptors, Calcitriol/blood , Multiple Sclerosis, Relapsing-Remitting/blood , Primary Dysautonomias/blood , Reference Values , Autonomic Nervous System Diseases/physiopathology , Vitamin D Deficiency/complications , Vitamin D Deficiency/blood , Blood Pressure/physiology , Enzyme-Linked Immunosorbent Assay , Case-Control Studies , Cross-Sectional Studies , Risk Factors , Supine Position/physiology , Statistics, Nonparametric , Multiple Sclerosis, Relapsing-Remitting/physiopathology , Primary Dysautonomias/etiology , Primary Dysautonomias/physiopathology , Heart Rate/physiology , Hypertension/physiopathology , Hypertension/blood , Hypotension, Orthostatic/physiopathology , Hypotension, Orthostatic/blood
6.
Rev. méd. Chile ; 147(11): 1415-1422, nov. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1094171

ABSTRACT

Background Sun exposure is the main source of 25-hydroxy-vitamin D. Since anesthesiologists work inside operating rooms, they are identified as a deficiency risk group. As medical activity in general occurs indoors, added to the work excess and sedentary lifestyle, physicians in general have low sun exposure. Aim To investigate the determinants of vitamin D levels in physicians. Material and Methods Anesthesiologists and physicians not working in operating rooms were included. A survey that comprised working hours, diet, skin color, sunscreen use and outdoor activities was also applied. Measurements of vitamin D and parathormone levels in blood were performed. Results We analyzed samples from 81 volunteers. Median vitamin D values of the whole sample were in the range of insufficiency (25.3 [interquartile range 12.4] ng/ml). Multiple linear regression analysis detected no differences between anesthesiologists and non-anesthesiologists. A higher body mass index was a risk factor for vitamin D deficiency, (p = 0.025). The only protective factor was the intake of a vitamin D supplement (p < 0.01). Conclusions Anesthesiologists and other specialists were both at risk for vitamin D deficiency. Obesity was a risk factor and the use of a vitamin D supplement was the only protective factor.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Parathyroid Hormone/blood , Vitamin D/analogs & derivatives , Vitamin D/blood , Vitamin D Deficiency/diagnosis , Dietary Supplements , Anesthesiologists/statistics & numerical data , Vitamin D/administration & dosage , Vitamin D Deficiency/blood , Body Mass Index , Cross-Sectional Studies , Risk Factors
7.
Arch. endocrinol. metab. (Online) ; 63(3): 265-271, May-June 2019. tab
Article in English | LILACS | ID: biblio-1011158

ABSTRACT

ABSTRACT Objective We investigated changes in body composition and nutritional and metabolic parameters in a group of postmenopausal women who were classified as sufficient, insufficient and deficient in vitamin D. Subjects and methods A total of 106 postmenopausal women were included in this cross-sectional study and classified according to their serum levels of 25-OH-vitamin D as sufficient (≥ 30 ng/mL; group S), insufficient (20.1 and 29.9 ng/mL; group I) or deficient (≤ 20 ng/mL; group D) in vitamin D. Body composition was measured by dual-energy X-ray absorptiometry (DXA); dietary recall questionnaires were completed; and blood samples were analysed to compare the metabolic and nutritional status of the study groups. Results Eleven (10.4%) of the women were classified in group S, 50 (47.2%) in group I and 45 (42.4%) in group D, with a mean serum level for 25-OH-D of 21.1 ± 7.0 ng/mL in all participants. Body composition did not differ among the groups. Serum levels of 25-OH-D were negatively correlated with serum levels of triglycerides, total cholesterol and LDL cholesterol. Conclusions Vitamin D insufficiency and deficiency were highly prevalent in our group of postmenopausal women, showing an association with an unfavourable lipid profile.


Subject(s)
Humans , Female , Adult , Middle Aged , Vitamin D/blood , Vitamin D Deficiency/blood , Postmenopause/blood , Triglycerides/blood , Vitamin D Deficiency/epidemiology , Blood Glucose/analysis , Body Composition , Brazil/epidemiology , Body Mass Index , Bone Density , Nutritional Status , Prevalence , Cross-Sectional Studies , Cholesterol, LDL/blood
8.
Medicina (B.Aires) ; 79(3): 217-224, June 2019. ilus, tab
Article in English | LILACS | ID: biblio-1020064

ABSTRACT

Hypovitaminosis D, defined by low serum levels of 25(OH)D, is a recognized worldwide public health problem. The most accepted definition considers that deficiency occurs with serum levels fall below 12 ng/ml of 25(OH)D. Long term vitamin D deficiency results in decreased bone mineralization, secondary hyperparathyroidism, increased cortical bone loss (pathogenesis of osteoporosis and hip fractures), differentiation and division of various cell types, muscle strength, diabetes type 2, blood pressure, etc. Twin- and family-based studies indicate that genetic factors influence serum 25(OH)D levels. Genetic studies have shown single-nucleotide polymorphisms (SNPs) are linked to low serum 25(OH)D concentrations through changes in the activity of the enzymes of the 1α,25(OH)2D metabolic pathway. Carriers of high genetic risk scores would need a h igher amount of vitamin D supplementation to achieve adequate serum 25(OH)D concentrations. Clinicians would not need to indicate studies to identify patients with vitamin D insufficiency of genetic origin. They should instruct their patients on their own care, to control the intake of vitamin D and the serum 25(OH)D levels until the latter are adequate. Overall, the literature reveals that the consequences of hypovitaminosis D on bone health are observed in old and infrequently in young subjects. A probable explanation for the latter is: if the rate of bone remodeling allows it, bone tissue has endogenous (genetics, hormones) and exogenous determinants (diet, physical activity) that may compensate the variables of bone health. The consequences of vitamin D deficit on bone health, has not been completely uncovered.


La hipovitaminosis D, definida por bajos niveles séricos de 25(OH)D (<12 ng/ml), es un reconocido problema de salud pública mundial. La deficiencia de vitamina D a largo plazo resulta en una disminución de la mi neralización ósea, hiperparatiroidismo secundario, pérdida de hueso cortical (patogénesis de la osteoporosis y fracturas de cadera), diferenciación y división de varios tipos de células, fuerza muscular, diabetes tipo 2, pres ión arterial, etc. Estudios genéticos han demostrado que algunos "polimorfismos de un solo nucleótido" (SNP) están relacionados con bajas concentraciones séricas de 25(OH)D a través de reducción en la actividad de las enzimas implicadas en la síntesis de 1α,25(OH)2D. Los médicos no necesitan indicar un estudio genético para identificar a la insuficiencia de vitamina D de causa genética. Bastará con instruir a los pacientes sobre su propio cuidado y controlar la ingesta de vitamina D y los niveles séricos de 25(OH)D hasta que estos últimos sean adecuados. En general, la literatura revela que las consecuencias de la hipovitaminosis D sobre la salud ósea se observan en las personas añosas y con poca frecuencia en sujetos jóvenes. Una explicación probable para esta situación es: si la tasa de remodelación ósea lo permite, el tejido óseo tiene factores endógenos (genéticos, hormonales) y exógenos (dieta, actividad física) que pueden compensar las variables de la salud ósea. Las consecuencias del déficit de vitamina D sobre la salud ósea aún no se conocen completamente.


Subject(s)
Humans , Male , Female , Vitamin D Deficiency/genetics , Bone Remodeling/genetics , Parathyroid Hormone/blood , Vitamin D Deficiency/blood , Bone Remodeling/physiology , Polymorphism, Single Nucleotide
9.
Int. braz. j. urol ; 45(3): 621-628, May-June 2019. tab, graf
Article in English | LILACS | ID: biblio-1012317

ABSTRACT

Abstract Purpose: To investigate the relationship between 25-hydroxyvitamin D (25 (OH) D) levels and acquired premature ejaculation (PE). Materials and Methods: A total of 97 patients with acquired PE and 64 healthy men as a control group selected from volunteers without PE attending our Andrology Outpatient Clinic between November 2016 and April 2017 were included the study. All patients were considered to have acquired PE if they fulfilled the criteria of the second Ad Hoc International Society for Sexual Medicine Committee. Premature ejaculation diagnostic tool questionnaires were used to assessment of PE and all participants were instructed to record intravaginal ejaculatory latency time. Vitamin D levels were evaluated in all participants using high performance liquid chromatography method included in the study. Results: Compared to men without PE, the patients with acquired PE had significantly lower 25 (OH) D levels (12.0 ± 4.5 ng/mL vs. 18.2 ± 7.4 ng/mL, p < 0.001). In the logistic regression analysis, 25 (OH) D was found to be an independent risk factor for acquired PE, with estimated odds ratios (95% CI) of 0.639 (0.460-0.887, p = 0.007) and the area under curve of the ROC curve of 25 (OH) D diagnosing acquired PE was 0.770 (95% CI: 0.695 to 0.844, p < 0.001). The best cut-off value was 16 ng/mL with a sensitivity of 60.9%, specificity of 83.5%, PPV of 70.9%, and NPV of 76.4% to indicate acquired PE. Conclusions: This study demonstrates that lower vitamin D levels are associated with the acquired PE. The result of our study showed that the role of serum vitamin D levels should be investigate in the etiology of acquired PE. Perhaps supplementation of vitamin D in men with acquired PE will ameliorate the sexual health of these patients.


Subject(s)
Humans , Male , Adult , Young Adult , Vitamin D/analogs & derivatives , Vitamin D Deficiency/complications , Vitamin D Deficiency/blood , Premature Ejaculation/etiology , Premature Ejaculation/blood , Testosterone/blood , Vitamin D/blood , Case-Control Studies , Logistic Models , Multivariate Analysis , Predictive Value of Tests , Prospective Studies , Surveys and Questionnaires , Risk Factors , ROC Curve , Middle Aged
10.
Rev. Assoc. Med. Bras. (1992) ; 65(5): 691-698, May 2019. tab, graf
Article in English | LILACS | ID: biblio-1012967

ABSTRACT

SUMMARY BACKGROUND: Hypovitaminosis D is considered a global public health issue. Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health. OBJECTIVES: The aim of this study was to evaluate the prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml, in postmenopausal women around the world, as well as to identify the potential associated factors. METHODS: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. Specific search terms were consulted in Medline, Excerpta Medica, and Latin-American and Caribbean Health Sciences Literature databases, with no restriction for the year or language of publication. RESULTS: Of 451 studies initially identified, 32 were selected for analysis. Collectively, those 32 studies evaluated 21,236 postmenopausal women, of whom 16,440 (77.4%) had serum 25-hydroxyvitamin D concentrations < 30 ng/ml. The reported prevalence of hypovitaminosis D ranged from 29% (in the United States) to 99.4% (in China). In six of the studies, the prevalence was above 90%. CONCLUSIONS: If the criterion is the 30 ng/ml cut-off point, the majority of postmenopausal women in the world could be classified as having hypovitaminosis D. Among the studies evaluated, the lowest prevalence reported was nearly 30%. Neither latitude, region of the world, nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis D.


RESUMO INTRODUÇÃO: A hipovitaminose D é considerada um problema de saúde pública global. O conhecimento de suas verdadeiras dimensões nos permitirá projetar intervenções e planejar medidas preventivas que possam ter um impacto significativo na saúde humana. OBJETIVO: O objetivo deste estudo foi avaliar a prevalência de hipovitaminose D, definida como concentração sérica de 25-hidroxivitamina D <30 ng/ml, em mulheres na pós-menopausa em todo o mundo, bem como identificar os potenciais fatores associados. MÉTODOS: Uma revisão sistemática foi realizada de acordo com as recomendações de Itens de Relatórios Preferenciais para Revisão Sistemática e Meta-Análises. Os termos de pesquisa específicos foram consultados nas bases de dados Medline, Excerpta Medica e Literatura Latino-Americana e do Caribe em Ciências da Saúde, sem restrição para o ano ou idioma de publicação. RESULTADOS: Dos 451 estudos inicialmente identificados, 32 foram selecionados para análise. Coletivamente, esses 32 estudos avaliaram 21.236 mulheres na pós-menopausa, das quais 16.440 (77,4%) apresentavam concentrações séricas de 25-hidroxivitamina D <30 ng/ml. A prevalência relatada de hipovitaminose D variou de 29% (nos Estados Unidos) a 99,4% (na China). Em seis dos estudos, a prevalência foi superior a 90%. CONCLUSÕES: Se o critério é o ponto de corte de 30 ng/ml, a maioria das mulheres na pós-menopausa no mundo poderia ser classificada como tendo hipovitaminose D. Entre os estudos avaliados, a menor prevalência relatada foi de quase 30%. Nem latitude, região do mundo, nem metodologia laboratorial foram encontrados para ser associados com a prevalência de hipovitaminose D.


Subject(s)
Humans , Female , Vitamin D Deficiency/blood , Vitamin D Deficiency/epidemiology , Postmenopause/blood , Vitamin D/analogs & derivatives , Vitamin D/blood , Prevalence , Risk Factors
11.
Rev. bras. cir. cardiovasc ; 34(1): 57-61, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-985249

ABSTRACT

Abstract Objective: To evaluate the association between serum vitamin D (vitD) level and SYNTAX (synergy between percutaneous coronary intervention with taxus and cardiac surgery) score (SS). Methods: The medical records of consecutive patients, who underwent coronary artery bypass graft surgery, were retrospectively reviewed. The study group consisted of 158 patients. Biochemical, clinical, and echocardiographic parameters and SS were evaluated in all patients. The patients were divided into 2 groups according to SS (≥23= high, <23= low). Results: The high SYNTAX score (HSS) group was older and had higher body mass index, C-reactive protein (CRP), low-density lipoprotein, and fasting plasma glucose level than the low SYNTAX score (LSS) group. The HSS group had lower high-density lipoprotein and vitD level than the LSS group. The HSS group had a higher prevalence of diabetes mellitus (DM), hypertension (HT), hyperlipidemia (HL), and current smoking patients than the LSS group. On univariate analysis, age, HT, DM, HL, smoking, CRP, and serum vitD level were associated with HSS. On multivariate analysis, HT, DM, and HL were independent predictors of HSS (odds ratio [OR]: 2.137, 95% confidence interval [CI]: 1.468-2.935, P<0.001; OR: 3.559, 95% CI: 2.763-5.927, P<0.001; OR: 2.631, 95% CI: 1.529-3.438, P<0.001; respectively). Conclusion: In our study, we have found out that HT, DM, and HL were independent predictors of HSS. Serum vitD level was not found to be an independent predictor of HSS.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Vitamin D/blood , Coronary Artery Disease/blood , Coronary Artery Disease/diagnostic imaging , Coronary Artery Bypass/methods , Coronary Angiography/methods , Risk Assessment/methods , Reference Values , Vitamin D Deficiency/blood , Coronary Artery Disease/etiology , Cross-Sectional Studies , Multivariate Analysis , Retrospective Studies , Risk Factors , Sensitivity and Specificity , Diabetes Complications , Percutaneous Coronary Intervention/methods , Hyperlipidemias/complications , Hypertension/complications
12.
Rev. chil. pediatr ; 90(1): 94-101, 2019. tab
Article in Spanish | LILACS | ID: biblio-990891

ABSTRACT

Resumen: El mejor entendimiento sobre la actividad global de la vitamina D, ha llevado a una intensa búsque da de sus implicancias en enfermedades no esqueléticas. En este artículo se presenta una revisión actualizada de la relación entre la vitamina D y la patología respiratoria pediátrica. Se realizó una búsqueda bibliográfica en PUBMED utilizando términos libres y MESH: vitamina D, enfermedades del sistema respiratorio, asma, bronquiolitis. Se seleccionó estudios en humanos menores de 18 años y animales, publicados en inglés y español hasta el 2017. Se encontraron 507 artículos, de los cuales se incluyeron 43. Evidencia indirecta apunta hacia un rol de la vitamina D y la maduración pulmonar fetal. En relación a la patología pulmonar pediátrica, los estudios son escasos y poco concluyentes. Nuevos meta - análisis, con evaluación individualizada de los participantes, muestran un importante rol protector de la suplementación en la prevención de exacerbaciones asmáticas severas e infecciones virales agudas. En bronquiolitis los resultados son contradictorios, sin relación clara entre niveles plasmáticos y severidad. No existe suficiente evidencia que evalué los beneficios en fibrosis quística y tuberculosis. Recientemente se ha propuesto una relación directa entre la severidad de los trastornos respiratorios del sueño y los niveles plasmáticos de vitamina D, aunque se desconoce los mecanismos exactos involucrados a esta asociación. La información actual permite suponer que la suplementación de vitamina D puede representar una estrategia costo - efectiva en la reducción de importantes causas de morbimortalidad infantil.


Abstract: The better understanding of the global activity of vitamin D has led to an intense search for its involvement in non-skeletal diseases. This article presents an updated review of the relationship between vitamin D and pediatric respiratory pathology. A literature search was performed in PUBMED using free terms and MESH terms: vitamin D, asthma, respiratory system diseases, and bronchiolitis. Stu dies in human patients younger than 18 years and animals, published in English and Spanish until 2017 were included. 507 articles were found, of which 43 were included. Indirect evidence suggests a role of vitamin D and fetal lung maturation. In relation to pediatric pulmonary pathology, studies are scarce and inconclusive. Recent meta-analyses performed with individualized evaluation of the participants shows an important protective role of vitamin D supplementation in the prevention of severe asthma exacerbations and acute viral infections. In bronchiolitis, the results are contradictory, with no clear relationship between plasma levels and severity. There is not enough evidence to assess the benefits of vitamin D supplementation in cystic fibrosis and tuberculosis. A direct relationship between the severity of sleep-related breathing disorders and vitamin D plasma levels has recently been proposed, although the exact mechanisms involved in this association are unknown. Current information suggests that vitamin D supplementation may represent a cost-effective strategy in redu cing important causes of infant morbidity and mortality.


Subject(s)
Humans , Child , Respiratory Tract Diseases/etiology , Vitamin D Deficiency/complications , Pediatrics , Respiratory Tract Diseases/prevention & control , Respiratory Tract Diseases/drug therapy , Vitamin D/physiology , Vitamin D/blood , Vitamin D/therapeutic use , Vitamin D Deficiency/diagnosis , Vitamin D Deficiency/drug therapy , Vitamin D Deficiency/blood , Vitamins/physiology , Vitamins/blood , Vitamins/therapeutic use , Biomarkers/blood , Risk Factors , Dietary Supplements , Lung/embryology
13.
Rev. Soc. Bras. Med. Trop ; 51(5): 596-602, Sept.-Oct. 2018. tab
Article in English | LILACS | ID: biblio-957462

ABSTRACT

Abstract INTRODUCTION: The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals. METHODS: A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient's weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected. RESULTS: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively. CONCLUSIONS: Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Vitamin D/blood , Vitamin D Deficiency/blood , Bone Density/physiology , HIV Infections/blood , Vitamin D Deficiency/physiopathology , Absorptiometry, Photon , HIV Infections/physiopathology , Prevalence , Cross-Sectional Studies , Middle Aged
14.
Arq. gastroenterol ; 55(3): 216-220, July-Sept. 2018. tab, graf
Article in English | LILACS | ID: biblio-973900

ABSTRACT

ABSTRACT BACKGROUND: An association has been established between low serum values of vitamin D and inflammatory bowel disease. There is a lack of evidence on whether this association is still observed in regions where sun exposure throughout the year is higher. OBJECTIVE: To compare the prevalence of vitamin D deficiency between inflammatory bowel disease patients and healthy controls. METHODS: Inflammatory bowel disease patients were consecutively enrolled as cases. Age and gender-matched healthy subjects who agreed to undertake a determination of serum vitamin D were enrolled as controls. Demographic features, medical treatment, need for hospital admission at diagnosis, steroid treatment, smoking, need for surgical treatment were evaluated as factors associated with vitamin D deficiency. RESULTS: Overall, 59 patients with a diagnosis of either Crohn's disease or ulcerative colitis were enrolled, as well as 56 controls. Median age was 41 years (19-79) and 56% were male. Vitamin D deficiency was observed in 66.1% of inflammatory bowel disease patients versus 21.42% of healthy controls (OR 7.15 (3.1-16.48), P=0.001). Among inflammatory bowel disease patients, male gender, disease duration, moderate-to-severe disease and hospital admission at the moment of diagnosis were found to be associated with vitamin D deficiency. On multivariate analysis, only longer disease duration [(OR 1.01 (1-1.06)] and hospital admission at diagnosis [(OR 5.63 (1.01-31.61)] were found to be significantly associated with the latter. CONCLUSION: Vitamin D deficiency was more frequent among inflammatory bowel disease patients. Longer disease duration and need for hospital admission at diagnosis were associated to vitamin D deficiency among these patients.


RESUMO CONTEXTO: Uma associação foi estabelecida entre os baixos valores séricos de vitamina D e doença inflamatória intestinal. Falta evidência se esta associação ainda é observada em regiões onde a exposição ao sol durante todo o ano é maior. OBJETIVO: Comparar a prevalência de deficiência de vitamina D entre pacientes com doença inflamatória intestinal e indivíduos controles saudáveis. MÉTODOS: Pacientes com doença inflamatória intestinal foram consecutivamente selecionados. Indivíduos saudáveis combinados da mesma idade e gênero que concordaram em fornecer uma determinação da vitamina D do soro foram considerados como controles. Características demográficas, tratamento médico, necessidade de admissão hospitalar no diagnóstico, tratamento de esteroides, tabagismo, necessidade de tratamento cirúrgico foram avaliados como fatores associados à deficiência de vitamina D. RESULTADOS: No geral, 59 pacientes com diagnóstico de doença de Crohn ou colite ulcerosa foram observados, bem como 56 controles. A idade mediana era de 41 anos (19-79) e 56% eram do sexo masculino. A deficiência de vitamina D foi observada em 66,1% dos pacientes com doença inflamatória intestinal versus 21,42% dos controles saudáveis (OR 7,15 (3.1-16.48), P=0,001). Entre os pacientes com doença inflamatória intestinal, sexo masculino, duração da doença, doença de moderada a severa e admissão hospitalar no momento do diagnóstico foram associados com a deficiência de vitamina D. Na análise multivariada, apenas a duração da doença [(OR 1; 1 (1-1,06)] e a admissão hospitalar no diagnóstico [(OR 5,63 (1,01-31,61)] foram encontradas significativamente associadas ao último. CONCLUSÃO: A deficiência de vitamina D foi mais frequente entre os pacientes com doença inflamatória intestinal. Maior duração da doença e necessidade de admissão hospitalar no diagnóstico foram associadas à deficiência de vitamina D entre esses pacientes.


Subject(s)
Humans , Male , Female , Adult , Aged , Young Adult , Vitamin D Deficiency/epidemiology , Colitis, Ulcerative/epidemiology , Crohn Disease/epidemiology , Argentina/epidemiology , Vitamin D Deficiency/complications , Vitamin D Deficiency/blood , Severity of Illness Index , Colitis, Ulcerative/complications , Colitis, Ulcerative/blood , Crohn Disease/complications , Crohn Disease/blood , Case-Control Studies , Prevalence , Cross-Sectional Studies , Multivariate Analysis , Risk Factors , Cholecalciferol/blood , Statistics, Nonparametric , Middle Aged
15.
Braz. j. otorhinolaryngol. (Impr.) ; 84(4): 453-459, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-951853

ABSTRACT

Abstract Introduction Benign paroxysmal positional vertigo is the most common cause of dizziness in the general population. It is a condition with potential impact of reduced levels of vitamin D on its recurrent attacks. Objectives The aim of this study was to measure the serum levels of 25-hydroxyvitamin D3 (25-OH D3) in patients with benign paroxysmal positional vertigo and determine whether there is a difference in the serum levels of vitamin D3 between patients with and without recurrence, as well as between the different clinical forms of benign paroxysmal positional vertigo. Methods The study included 40 patients who came to the regular medical examination, diagnosed with posterior canal-benign paroxysmal positional vertigo based on the positive Dix-Hallpike's test. All patients underwent Epley manoeuvre after the diagnosis. Patients were classified according to current guidelines for levels of vitamin D3 in the serum in three groups: the deficiency, insufficiency and adequate level. Results The average serum level of 25-OH D3 among respondents was 20.78 ng/mL, indicating a lack or insufficiency of the aforementioned 25-OH D3. According to the levels of 25-OH D3, most patients suffer from deficiency (47.5%). 7 (17.5%) respondents had adequate blood level of 25-OH D3, and 14 (35%) respondents suffer from insufficiency. A significant difference was not found in the serum level of 25-OH D3 between patients with and without benign paroxysmal positional vertigo recurrence. There was a significant difference in the serum levels of 25-OH D3 in comparison to the clinical form of the disease. Lower 25-OH D3 values were found in patients with canalithiasis compared to those with cupulolithiasis. Conclusions There were no significant differences in the vitamin D3 serum level in patients with and without recurrence. The study showed a low level of serum vitamin D3 in most patients, indicating the need for supplemental therapy.


Resumo Introdução Vertigem posicional paroxística benigna é a causa mais comum de tonturas na população em geral. É uma condição no qual níveis reduzidos de vitamina D podem ter um potencial impacto para o desenvolvimento de crises recorrentes. Objetivos O objetivo desse estudo foi medir os níveis séricos de 25-hidroxivitamina D3 (25-OH D3) em pacientes com vertigem posicional paroxística benigna e determinar se há diferença nos níveis séricos de vitamina D3 entre pacientes com e sem recorrência, bem como entre as diferentes formas clínicas de vertigem posicional paroxística benigna. Método O estudo incluiu 40 pacientes submetidos a exame médico regular, diagnosticados com vertigem posicional paroxística benigna de canal posterior baseado no resultado positivo do teste de Dix-Hallpike. Todos os pacientes foram submetidos à manobra de Epley após o diagnóstico. Os pacientes foram classificados de acordo com as diretrizes atuais para os níveis de vitamina D3 sérica em três grupos: deficiência, insuficiência e nível adequado. Resultados O nível sérico médio de 25-OH D3 entre os indivíduos avaliados foi de 20,78 ng/mL, indicando falta ou insuficiência desta vitamina. De acordo com os níveis de 25-OH D3, a maioria dos pacientes apresentou deficiência (47,5%). Sete indivíduos (17,5%) entrevistados tinham nível sanguíneo adequado de 25-OH D3 e 14 (35%) apresentavam insuficiência. Não foi encontrada diferença significativa no nível sérico de 25-OH D3 entre pacientes com e sem recidiva de vertigem posicional paroxística benigna. Houve uma diferença significativa nos níveis séricos de 25-OH D3 de acordo com a forma clínica da doença. Baixos níveis de 25-OH D3 foram mais encontrados em pacientes com canalitíase em comparação com aqueles com cupulolitíase. Conclusões Não houve diferenças significativas no nível sérico de vitamina D3 em pacientes com e sem recorrência. O estudo mostrou um baixo nível de vitamina D3 sérica na maioria dos pacientes, indicando a necessidade de terapia suplementar.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Calcifediol/blood , Cholecalciferol/blood , Benign Paroxysmal Positional Vertigo/blood , Recurrence , Reference Values , Vitamin D Deficiency/blood , Calcium/blood , Statistics, Nonparametric , Benign Paroxysmal Positional Vertigo/pathology
16.
Arch. endocrinol. metab. (Online) ; 62(4): 452-459, July-Aug. 2018. tab
Article in English | LILACS | ID: biblio-950083

ABSTRACT

ABSTRACT Objective: This study was conducted to assess the serum 25-hydroxy (OH) vitamin D levels in patients with breast cancer compared to healthy controls and to identify its association with aggressive breast cancer phenotypes. Materials and methods: Serum 25-OH vitamin D levels of 78 breast cancer patients and 78 matched healthy controls were estimated using ELISA. The cases and controls were matched with respect to age, menopausal status, parity, weight, height and co-morbidities. Prognostic factors like grade of tumour, hormone receptor status, HER2 neu status and lymphovascular invasion were compared with 25-OH vitamin D levels. Results: The mean serum 25-OH vitamin D levels of cases were significantly lower compared to the controls (22.33 ± 8.19 vs. 37.41 ± 12.9 ng/mL; p = 0.0001). Patients with higher grades of tumour, non-luminal types of breast cancer and breast cancers with estrogen receptor negativity had significantly lower serum 25-OH vitamin D levels than their opposing groups. Patients with excellent and good Nottingham's prognostic Index (NPI) had significantly higher serum 25-OH vitamin D levels than the moderate and poor NPI groups. Conclusion: Newly diagnosed breast cancer patients have significantly lower serum 25-OH vitamin D levels than healthy controls. Lower level of serum 25-OH vitamin D correlates with aggressive breast cancer phenotypes.


Subject(s)
Humans , Female , Adult , Middle Aged , Vitamin D/analogs & derivatives , Vitamin D Deficiency/blood , Breast Neoplasms/blood , Phenotype , Prognosis , Vitamin D/blood , Vitamin D Deficiency/complications , Breast Neoplasms/etiology , Breast Neoplasms/genetics , Case-Control Studies , Neoplasm Grading , Tertiary Care Centers/statistics & numerical data , India
17.
Arch. endocrinol. metab. (Online) ; 62(2): 193-200, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-887652

ABSTRACT

ABSTRACT Objective To study the effect of using a one time high dose "stoss therapy" of vitamin D2 (ergocalciferol: VD2) on indices of insulin sensitivity {whole body sensitivity index: WBISI} and secretion {insulinogenic index: IGI} measured during an oral glucose tolerance test (OGTT) in obese adolescents with VDD (25 OHD; serum metabolite of vit D: < 30 ng/dL). Subjects and methods In a randomized placebo controlled cross over design 20 obese adolescents with vitamin D deficiency (VDD) had baseline OGTT. Arm A received one time high dose 300,000 IU of ergocalciferol and Arm B received placebo. After 6 weeks the adolescents were reassigned to Arm A if they were in Arm B and vice versa. 25OHD, calcium, parathyroid hormone, comprehensive metabolic panel, urine calcium creatinine ratio were measured at each study visit. OGTTs to assess indices of sensitivity and secretion were done at baseline, 6 weeks and 12 weeks respectively. Results Adolescents were obese and insulin resistant (mean ± SD: mean age = 15.1 ± 1.9 years; BMI: 32.7 ± 9.8; homeostatic model of insulin resistance: HOMA-IR: 4.2 ± 2.8). Stoss therapy with VD2 increased 25OHD from baseline (16.7 ± 2.9 to 19.5 ± 4.5; p = 0.0029) when compared to the placebo. WBISI (2.8 ± 1.9) showed a trend towards improvement in Rx group (p = 0.0577) after adjustment for covariates. IGI (3 ± 2.2) showed an improvement in both Rx and placebo groups. Conclusions Our study demonstrated that using a high dose of VD2 (300,000 IU) did not have any beneficial effect on insulin sensitivity (whole body sensitivity index {WBISI}) and secretory indices (insulinogenic index {IGI}) in obese adolescents. High dose "stoss therapy" of VD2 did not appear to have any beneficial effect on glucose homeostasis on obese adolescents.


Subject(s)
Humans , Male , Female , Adolescent , Vitamin D Deficiency/drug therapy , Vitamins/administration & dosage , Ergocalciferols/administration & dosage , Pediatric Obesity/blood , Vitamin D Deficiency/complications , Vitamin D Deficiency/blood , Blood Glucose/drug effects , Insulin Resistance , Body Mass Index , Cross-Over Studies , Pediatric Obesity/complications , Glucose Tolerance Test , Homeostasis/drug effects
18.
Medicina (B.Aires) ; 78(1): 6-10, feb. 2018. graf, tab
Article in Spanish | LILACS | ID: biblio-894539

ABSTRACT

Múltiples estudios muestran la importancia de mantener niveles suficientes de vitamina D para prevenir varias enfermedades crónicas. Sin embargo, la suplementación de vitamina D sobre la calciuria es controvertida. El objetivo de este trabajo prospectivo, intervencionista, fue evaluar la respuesta de la calciuria en mujeres con hipercalciuria y normocalciuria, luego de conseguir niveles adecuados de 25 OH D. Se estudiaron 63 mujeres con hipercalciuria idiopática (9 con litiasis renal) y 50 mujeres normocalciúricas. Ambos grupos presentaron déficit/insuficiencia de 25 OH D y fueron suplementadas con vitamina D2 o D3 semanales o vitamina D3 en dosis de 100 000 UI mensuales. A todas se les midió la calciuria basal y final al alcanzar el valor de 25 OH D deseado (> 30 ng/dl). No observamos cambios significativos en los valores de la calciuria inicial y final en las que recibieron vitamina D2 o D3 semanal ni en las que recibieron dosis mensuales. Sin embargo, un subgrupo de mujeres: 19% (n = 12) de las hipercalciúricas y 12% (n = 6) de las normocalciúricas (con vitamina D semanal) aumentaron la calciuria en forma significativa. Mientras que, con dosis mensuales, un 40% (n = 4/10) de las hipercalciúricas y 44% (n = 4/9) de las hipercalciúricas con litiasis renal aumentaron la calciuria. En conclusión, niveles adecuados de 25 OH D son seguros en la mayoría de las pacientes. En aquellas que requieren dosis de carga mensuales podrían observarse aumentos de la calciuria en forma significativa con riesgo de formar cálculos renales o perder masa ósea, cuando están genéticamente predispuestas.


Several studies show the importance of serum vitamin D sufficient levels to prevent multiple chronic diseases. However, vitamin D supplementation and its effects on urine calcium excretion remain controversial. The objective of this prospective and interventional study was to evaluate urine calcium excretion in women with normal calciuria or hypercalciuria, once serum vitamin D sufficiency was achieved. We studied 63 women with idiopathic hypercalciuria, (9 with renal lithiasis) and 50 normocalciuric women. Both groups had serum vitamin D levels low (deficiency or insufficiency). Baseline urine calcium excretion was measured before being supplemented with vitamin D2 or D3 weekly or vitamin D3 100.000 IU monthly. Once serum vitamin D levels were corrected achieving at least 30 ng/ml, a second urine calcium excretion was obtained. Although in the whole sample we did not observe significant changes in urine calcium excretion according to the way of supplementation, some of those with weekly supplementation had significant higher urine calcium excretion, 19% (n = 12) of hypercalciuric women and 12% (n = 6) of the normocalciuric group. Monthly doses, also showed higher urine calcium excretion in 40% of hypercalciuric women (n = 4/10) and in 44% (n = 4/9) of the renal lithiasis hypercalciuric patients. In conclusion, different ways of vitamin D supplementation and adequate serum levels are safe in most patients, although it should be taken into account a subgroup, mainly with monthly loading doses, that could increase the calciuria significantly eventually rising renal lithiasis risk or bone mass loss, if genetically predisposed.


Subject(s)
Humans , Female , Middle Aged , Aged , Vitamin D Deficiency/diet therapy , Calcium, Dietary/administration & dosage , Dietary Supplements , Vitamin D Deficiency/blood , Calcium, Dietary/adverse effects , Prospective Studies , Hypercalciuria/diagnosis , Hypercalciuria/etiology
19.
Einstein (Säo Paulo) ; 16(1): eAO4143, 2018. tab, graf
Article in English | LILACS | ID: biblio-891452

ABSTRACT

Abstract Objective We evaluated the association between vitamin D levels and nutritional status, pulmonary function and pulmonary exacerbations in children and adolescents with cystic fibrosis. Methods 25-hydroxyvitamin D (25(OH)D) levels of 37 children and adolescents were retrospectively evaluated. Pulmonary function, body mass index, height for age, and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: sufficient (≥30ng/mL) and hypovitaminosis (<30ng/mL). Results Hypovitaminosis D (25(OH)D <30ng/mL) was observed in 54% of subjects. The mean level of 25(OH)D was 30.53±12.14ng/mL. Pulmonary function and nutritional status were not associated with vitamin D levels. Pulmonary exacerbations over a 2-year period (p=0.007) and the period from measurement up to the end of the follow-up period (p=0.002) were significantly associated with vitamin D levels. Conclusion Hypovitaminosis D was associated with higher rates of pulmonary exacerbations in this sample of children and adolescents with cystic fibrosis. Hypovitaminosis D should be further studied as a marker of disease severity in cystic fibrosis. Further prospective and randomized studies are necessary to investigate causality of this association.


RESUMO Objetivo Avaliar a associação entre níveis de vitamina D e estado nutricional, função pulmonar e exacerbações pulmonares em crianças e adolescentes com fibrose cística. Métodos Os níveis de 25-hidroxivitamina D (25(OH)D) de 37 crianças e adolescentes foram avaliados retrospectivamente. Função pulmonar, índice de massa corporal, altura para a idade, e episódios de exacerbações pulmonares foram associados aos níveis de vitamina D divididos em dois grupos: suficiente (≥30ng/mL) e hipovitaminose (<30ng/mL). Resultados Hipovitaminose D (25(OH)D <30ng/mL) foi observada em 54% dos pacientes. O nível médio de 25(OH)D foi de 30,53±12,14ng/mL. A função pulmonar e o estado nutricional não foram associados aos níveis de vitamina D. As exacerbações pulmonares durante um período de 2 anos (p = 0,007) e do período de medição até o final do período de seguimento (p=0,002) foram significativamente associadas aos níveis de vitamina D. Conclusão A hipovitaminose D esteve associada a maiores taxas de exacerbações pulmonares nesta amostra de crianças e adolescentes com fibrose cística. A hipovitaminose D deve ser mais estudada como marcador da gravidade da doença na fibrose cística. Outros estudos prospectivos e randomizados são necessários para investigar a relação causal desta associação.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Young Adult , Vitamin D Deficiency/physiopathology , Forced Expiratory Volume/physiology , Cystic Fibrosis/physiopathology , Spirometry , Vitamin D Deficiency/complications , Vitamin D Deficiency/blood , Body Mass Index , Nutritional Status , Cross-Sectional Studies , Retrospective Studies , Cystic Fibrosis/complications , Cystic Fibrosis/blood
20.
ABCD arq. bras. cir. dig ; 31(4): e1407, 2018. tab, graf
Article in English | LILACS | ID: biblio-973366

ABSTRACT

ABSTRACT Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency. Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up. Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. The study investigated the results of the following biochemical tests: serum calcium, ionized calcium, vitamin D, and parathormone (PTH). The generalized estimating equations (GEE) determined the nutritional deficiencies using a significance level of 5%. Results : Among the patients who finished the study (120 months), 82.86% (n=29) had vitamin D deficiency, and 41.94% (n=13) had high PTH. Postoperative time had a significant effect on PTH (p=0.0059). The percentages of patients with vitamin D, serum calcium, and ionized calcium deficiencies did not change significantly over time. Conclusion : One of the outcomes was vitamin D deficiency associated with secondary hyperparathyroidism. These findings reaffirm the importance of monitoring the bone metabolism of patients submitted to Roux-en-Y gastric bypass. HEADINGS: Calcium deficiency. Vitamin D deficiency. Secondary hyperparathyroidism.


Resumo Racional: Pacientes submetidos ao bypass gástrico em Y-de-Roux, podem apresentar alterações do metabolismo do cálcio e hiperparatireoidismo secundário à deficiência de vitamina D. Objetivo: Avaliar as deficiências nutricionais relacionadas ao metabolismo do cálcio de pacientes submetidos à bypass gástrico em Y-de-Roux, com seguimento de 10 anos. Método: Um estudo retrospectivo longitudinal foi conduzido com pacientes submetidos à bypass gástrico em Y-de-Roux, em uma Clínica Multidisciplinar no Sudeste do Brasil. Investigou-se a frequência do acompanhamento médico e nutricional e os exames bioquímicos de cálcio sérico, cálcio iônico, vitamina D e paratormônio (PTH). Para a análise das deficiências nutricionais, foram utilizadas as Equações de Estimativas Generalizadas (EEG), com nível de significância de 5%. Resultados: Dos pacientes que permaneceram no estudo até o final (120 meses), 82,86% (29), apresentaram níveis de deficiência de vitamina D e 41,94% (13) apresentaram PTH elevado. O efeito do tempo foi significativo para o PTH (p=0,0059). Para a vitamina D, cálcio sérico e cálcio iônico, o percentual de deficiência manteve-se constante ao longo do tempo, sem diferença significativa entre os tempos. Conclusão: A deficiência de vitamina D, associada ao hiperparatireoidismo secundário, foi um desfecho encontrado. Tais achados reafirmam a importância do cuidado com o metabolismo ósseo, em pacientes submetidos à bypass gástrico em Y-de-Roux.


Subject(s)
Humans , Parathyroid Hormone/blood , Vitamin D Deficiency/etiology , Gastric Bypass/adverse effects , Calcium/blood , Malnutrition/etiology , Hyperparathyroidism/etiology , Postoperative Complications , Postoperative Period , Time Factors , Vitamin D Deficiency/blood , Vitamin D Deficiency/epidemiology , Brazil/epidemiology , Prevalence , Retrospective Studies , Follow-Up Studies , Longitudinal Studies , Malnutrition/blood , Malnutrition/epidemiology , Hyperparathyroidism/blood , Hyperparathyroidism/epidemiology
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