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1.
Int. braz. j. urol ; 42(1): 146-153, Jan.-Feb. 2016. tab, graf
Article in English | LILACS | ID: lil-777330

ABSTRACT

ABSTRACT Purpose To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. Materials and Methods Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated. Results Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group. Conclusions The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.


Subject(s)
Animals , Male , Penis/blood supply , Priapism/prevention & control , Vasodilator Agents/pharmacology , Reperfusion Injury/prevention & control , Dipyridamole/pharmacology , Ischemia/prevention & control , Penis/pathology , Priapism/pathology , Time Factors , Penile Erection/drug effects , Serum Albumin , Biomarkers/blood , Random Allocation , Reproducibility of Results , Treatment Outcome , Oxidants/blood , Rats, Sprague-Dawley , Oxidative Stress , Ischemic Preconditioning/methods , Disease Models, Animal , Serum Albumin, Human , Malondialdehyde/blood , Antioxidants/analysis
2.
Rev. med. nucl. Alasbimn j ; 13(51)Jan. 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-580237

ABSTRACT

Introducción. Frecuentemente los estudios de perfusión miocárdica con dipiridamol (DIP) son analizados cuantitativamente usando bases de datos de ejercicio (EXE). Objetivo. Comparar un grupo de pacientes con enfermedad coronaria conocida, procesados con bases de datos de DIP y EXE. Métodos. Se analizó los SPECT de perfusión miocárdica con Tc99m-Sestamibi y DIP de 20 hombres y 19 mujeres. Luego de su procesamiento, las imágenes de DIP SPECT fueron comparadas con bases de datos de mapas polares de EXE y DIP. Se analizó la extensión (en pixeles) y la severidad (DS) de los defectos y de las zonas reversibles. Resultados. Hubo concordancia de 92 por ciento en las interpretaciones de los estudios que tenían necrosis, isquemia o ambos (kappa: 0,859). El tamaño de los defectos de estrés fue el mismo con ambas bases de datos tanto en hombres como en mujeres. Sin embargo, en hombres la reversibilidad fue mayor (156,4 +/- 107,7 versus 128,6 +/-113,6 píxeles; p=0,0251) y más severa (699,6 +/- 665,8 versus 486,6 +/- 551,9 SD; p=0,0003) con EXE. En mujeres la reversibilidad fue menor (92,8 +/- 110,3 versus 113 +/- 121,9 pixeles; p=0,0024) y menos severa (278,5 +/- 356,7 versus 363,8 +/-432,7 SD; p=0,0009) con EXE. Conclusiones. Los pacientes que se sometieron a DIP fueron clasificados correctamente como isquemia, necrosis o ambos usando bases de datos de mapas polares de EXE. No obstante, la base de datos EXE subestimó la extensión de los defectos en mujeres y la sobreestimó en hombres.


Background. Frequently, dipyridamole (DIP) myocardial perfusion SPECT is analyzed quantitatively using an exercise (EXE) database. Objective. To compare a group of patients with known coronary artery disease, processed with DIP and EXE polar maps. Method. We studied 20 males and 19 females with DIP Tc99m-Sestamibi myocardial SPECT. After similar processing, the DIP SPECT images were read using both EXE and DIP polar map databases. We analyzed defect and reversibility extension (in pixels) and severity in standard deviations. Results. Agreement to classify patients as having necrosis, ischemia or both was 92 percent (kappa: 0.859). Stress defect size was similar with both databases in males and females. However, in males reversibility resulted larger (156.4 +/- 107.7 versus 128.6 +/- 113.6 pixels; p=0.0251) and more severe (699.6 +/- 665.8 versus 486.6 +/- 551.9 SD; p=0.0003) with EXE. In females, reversibility resulted smaller (92.8 +/- 110.3 versus 113.0 +/- 121.9 pixels; p=0.0024) and less severe (278.5 +/- 356.7 versus 363.8 +/- 432.7 SD; p=0,0009) with EXE. Conclusion. Patients undergoing DIP stress were correctly classified as presenting ischemia, necrosis or both by EXE polar map database. However, EXE database underestimated ischemia extension in females and overestimated it in males.


Subject(s)
Humans , Male , Adult , Female , Middle Aged , Databases as Topic , Coronary Disease , Tomography, Emission-Computed, Single-Photon/methods , Heart , Dipyridamole/pharmacology , Sex Factors , Myocardial Perfusion Imaging , Image Interpretation, Computer-Assisted , Myocardial Ischemia , Exercise Test
3.
Rev. med. nucl. Alasbimn j ; 13(50)Oct. 2010. ilus, tab
Article in Spanish | LILACS | ID: lil-580229

ABSTRACT

Fundamento y objetivo: Se trata de un estudio transversal donde se han determinado los valores de sensibilidad y especificidad del estudio de perfusión miocárdica con 99mTc-Tetrofosmina en protocolo de un día tras estímulo farmacológico con dipiridamol, en una población de mujeres previamente revascularizadas, así como la relación con los territorios vasculares coronarios, tomando como referencia la coronariografía. Pacientes: Se han estudiado con carácter retrospectivo 53 historias clínicas de mujeres sometidas a una prueba de perfusión miocárdica y a una coronariografía de control. Resultados: Los valores de sensibilidad y especificidad para la población fueron de 64,29 por ciento y 75,0 por ciento respectivamente. Por territorio arterial coronario, los valores de sensibilidad y especificidad para la arteria DA fueron de 68,75 por ciento y 75,0 por ciento respectivamente, para la Cx de 37,93 por ciento y 88,89 por ciento, y para la CD de 46,43 por ciento y 60,71 por ciento. Conclusiones: En las mujeres que han sido previamente revascularizadas, la gammagrafía de perfusión miocárdica con 99mTc-Tetrofosmina y dipiridamol en protocolo de un día parece ser una prueba idónea para realizar el seguimiento de pacientes.


Background: This is a cross-sectional study to identify the values of sensitivity and specificity of myocardial perfusion imaging with 99mTc-tetrofosmin one-day protocol after pharmacological stimulation with dipyridamole in a population of women previously revascularized and the relationship of findings to coronary vascular territories, with coronary angiography as a gold standard. Patients We studied retrospectively 53 medical records of women undergoing myocardial perfusion test and control coronary angiography. Results: The sensitivity and specificity for the population were 64.29 percent and 75.0 percent respectively. For coronary artery territory, the values of sensitivity and specificity for the LAD were 68.75 percent and 75.0 percent respectively, for Cx of 37.93 percent and 88.89 percent, and for the RCA 46.43 percent and 60.71 percent. Conclusions: In women who have been previously revascularized, myocardial perfusion scintigraphy with 99mTc-tetrofosmin and dipyridamole in one-day protocol seems to be a suitable test to monitor patients.


Subject(s)
Humans , Female , Organophosphorus Compounds , Organotechnetium Compounds , Heart , Myocardial Perfusion Imaging , Myocardial Revascularization/methods , Coronary Angiography , Heart , Heart , Postoperative Care , Dipyridamole/pharmacology , Cross-Sectional Studies , Exercise Test , Radiopharmaceuticals , Sensitivity and Specificity , Predictive Value of Tests
4.
Sudanese Journal of Dermatology. 2006; 4 (1): 28-34
in English | IMEMR | ID: emr-81273

ABSTRACT

An up-to-date overview of antithrombotic drugs, with their currently reported beneficial cutaneous effects and skin side effect, is presented. Attempts to balance traditional pharmacodynamic concepts with the newly described empiric benefits are made. A concise, current and useful reference for dermatologists with an interest in dermatopharmacology and the practicing physician in the field of wound care, vasculitides and skin involvement of internal diseases is tried to be achieved


Subject(s)
Humans , Fibrinolytic Agents/adverse effects , Dipyridamole/adverse effects , Pentoxifylline/adverse effects , Pentoxifylline/pharmacology , Ticlopidine/pharmacology , Ticlopidine/adverse effects , Aspirin/pharmacology , Dipyridamole/pharmacology , Aspirin/adverse effects
6.
Indian J Exp Biol ; 1997 Apr; 35(4): 342-7
Article in English | IMSEAR | ID: sea-62756

ABSTRACT

The effects of adenosine (100 nM, icv), dipyridamole (DPM, 5 mg/kg, i.p.), adenosine A1 receptor antagonist 8-cyclopentyl-theophylline (8-CPT, 10 mg/kg, i.p.), and aminophylline (AMP) and caffeine (CAF) (at equivalent doses of 35 mg/kg, i.p.), were examined in rats. Anti-epileptic drugs (AEDs) were also administered i.p., viz, carbamazepine (CBZ, 10 mg/kg); phenobarbitone (PB, 10 mg/kg); phenytoin (PHT, 20 mg/kg); valproic acid (VPA, 300 mg/kg); and diazepam (DZP, 10 mg/kg), to study their effects on EEG after discharge (AD) and postictal depression (PID) induced by cortical stimulation. The AD parameters: (1) duration of EEG-AD (sec) and (2) number of spikes was noted both during pre and post drug treatment sessions. Adenosine and DPM had no special effects on AD parameters but showed significant prolongation of PID. All the adenosine antagonists, 8-CPT, AMP and CAF produced significant prolongation of AD duration, increase in number of spikes and reduced the duration of PID to a significant extent. Interestingly, some of the AEDs, viz. CBZ, VPA and DZP showed abolition of all the EEG-AD parameters whereas PB and PHT failed to show any significant effect. The results confirm previous findings on involvement of adenosine in postictal events.


Subject(s)
Adenosine/antagonists & inhibitors , Aminophylline/pharmacology , Animals , Anticonvulsants/pharmacology , Cerebral Cortex/drug effects , Dipyridamole/pharmacology , Electric Stimulation , Electroencephalography , Female , Male , Rats , Rats, Wistar , Seizures/physiopathology , Theophylline/analogs & derivatives
8.
JPMA-Journal of Pakistan Medical Association. 1994; 44 (10): 237-239
in English | IMEMR | ID: emr-33029

ABSTRACT

Exercise Thallium-201 myocardial perfusion imaging is a sensitive technique for detection of CAD. However, in patients unable to perform exercise pharmacological stress with intravenous dipyridamole can be used to dilate coronaries. Out of 125 patients [21 men and 104 women; mean age 52.03 years] evaluated, 110 were considered to be unable to perform adequate stress by their physician while remaining 15 had LBBB. One hundred and seven patients had chest pain with or without a remote MI while 18 individuals were clinically asymptomatic but had ECG abnormalities. Intravenous dipyridamole was administerted at a rate of 0.142 mg/kg/min for 4 min. After 3 min an i.v. bolus of T1-201 was given. Diffuse or occipital headache of mild to moderate intensity occurred in 50 [40%] cases; 39 patients experienced chest pain and had either a positive thallium scan [26 cases] suggestive of CAD or a normal thallium study [15 cases]. Complete relief from dipyridamole induced symptoms was brought by i.v. aminophylline and sublingual nitrate in 51 of 54 cases [94%] and 11 of 18 [61%] respectively. We, therefore, conclude: 1] i.v. dipyridamole-thallium scintigraphy offers a safe, effective and reliable method for evaluating CAD in those who are unable to perform adequate exercise and 2] parenteral aminophylline is very effective antidote to dipyridamole


Subject(s)
Humans , Male , Female , Exercise Test/methods , Stress, Physiological , Dipyridamole/pharmacology , Coronary Disease/drug therapy
9.
Indian J Physiol Pharmacol ; 1993 Oct; 37(4): 342-4
Article in English | IMSEAR | ID: sea-107964

ABSTRACT

The effect of dipyridamole (DPM), a purine nucleoside uptake inhibitor, on the K+ and noradrenaline (NA)-stimulated 45Ca-uptake into Rabbit aortic strips was studied and compared with that of nifedipine (NFD). DPM (10(-6) M) significantly (P < 0.02) inhibited 45Ca-uptake in aortic strips stimulated with K+ (10(-1) M). However, it had less significant effect on NA (10(-4) M)-stimulated 45Ca-uptake. The percentage inhibition was 80 and 57 in K+ and NA-stimulated 45Ca-uptake, respectively. Similarly, NFD (10(-7) M) caused significant (P < 0.01, P < 0.05) decrease in K+ (0.060 +/- 0.009) and NA (0.082 + 0.01, mM)-stimulated 45Ca-uptake. The percentage inhibition by NFD was 98 and 64 in K+ and NA-stimulated 45Ca-uptake, respectively. The results suggest that DPM inhibits Ca2+ influx occurring through Voltage Operated Calcium Channels (VOCCs) but it has little effect on Receptor Operated Calcium Channels (ROCCs).


Subject(s)
Animals , Aorta, Thoracic/drug effects , Calcium/metabolism , Calcium Channels/drug effects , Dipyridamole/pharmacology , Female , Male , Muscle, Smooth, Vascular/drug effects , Nifedipine/pharmacology , Norepinephrine/pharmacology , Potassium/pharmacology , Rabbits
10.
New Egyptian Journal of Medicine [The]. 1993; 8 (4): 1185-9
in English | IMEMR | ID: emr-29789

ABSTRACT

The present study included 25 pregnant women having mild hypertension. Doppler ultrasound was done for each case included in the study before and after treatment with dipyridamole [75 mg tablet, three times daily] for one week with the objective of finding the effect of dipyridamole on fetal hemodynamic. The study consists of two subgroups. The first subgroup included 15 cases of mild pregnancy induced hypertension, their mean arterial blood pressure was 110.44 +/- 3.91 mmHg. It dropped to 105 +/- 4.34 mmHg after dipyridamole treatment. The second subgroup included 10 cases of controlled essential hypertension with pregnancy who were under treatment with alpha-methyl dopa [Aldomet] 250 mg tablets, three times daily from before pregnancy, their mean arterial blood pressure was 115.67 +/- 36.86 mmHg which dropped to 109.4 +/- 4.83 mmHg after dipyridamole treatment for one week. The mean A/B ratio in the fetal aorta, and umbilical artery of the total study group was found to drop from 6.77 +/- 3.91, and 2.92 +/- 0.63 before dipyridamole treatment to 4.49 +/- 1.32, and 2.26 +/- 0.38 after treatment in the two blood vessels respectively. Regarding the mean [RI] in the fetal aorta, and the umbilical artery of the total study group, it was found that it dropped from 0.82 +/- 0.71, and 0.64 +/- 0.29 before dipyridamole treatment to 0.75 +/- 0.09, and 0.25 +/- 0.08 after treatment in the two blood vessels respectively. The improvement in the Doppler parameters was observed to occur more among the PIH subgroup of patients when compared to the Ess. H. group. In conclusion, dipyridamole was found to have an effect on the fetal hemodynamics as it improve the A/B ratio, and it decreased the RI and PI in cases having hypertensive disease with pregnancy


Subject(s)
Humans , Female , Dipyridamole/pharmacology , Pregnancy Complications , Hypertension/drug effects , Ultrasonics
11.
Rev. colomb. cardiol ; 3(7): 399-405, jun. 1991. ilus, tab, graf
Article in Spanish | LILACS | ID: lil-219448

ABSTRACT

Para efectos diagnósticos, se evaluaron los cambios inducidos sobre los signos Doppler de flujo transmitral por una infusión intravenosa de dipiridamol (0.14 mgs/Kg/min durante 4 min) en 10 enfermos coronarios y en 10 sujetos sanos. Durante el período de máxima acción farmacológica del dipiridamol, en el grupo coronario 4 pacientes presentaron angina (vs. 0 en el grupo control), en 6 se detectaron trastornos segmentarios de la contarctilidad (vs. 0 en el grupo control) y en todos se acentuaron o aparecieron signos de disfunción diastólica ventricular izquierda sobre las ondas Doppler de flujo transmitral (vs. 0 en el grupo control). La relación de velocidades pico E/A fue <1 en todos los enfermos coronarios y >1 en todos los sujetos sanos. La fracción porcentual del llenado temprano (E/T por ciento), se incrementó en todos los sujetos sanos (59.5 por ciento ñ 4.5 basal a 67 por ciento ñ 2.6 por ciento durante Dip.), mientras que en grupo coronario disminuyó en 9 de 10 pacientes (49.2 por ciento ñ 12.8 por ciento basal a 42 por ciento ñ 10 por ciento Dip.), p<0.001. La fracción porcentual del llenado tardío (A/T por ciento) aumentó en todos los casos, pero fue significativamente mayor en el grupo coronario. La duración del llenado total (DLLT) fue menor en el grupo coronario, indicando una prolongación del período de relajación isovolumétrico. Estos hallazgos sugieren que la isquemia generada por la infusión IV. de dipiridamol en pacientes con enfermedad coronaria,produce anormalidades en el patrón de flujo transmitral caracterizados por disminución del llenado ventricular durante la fase rápida temprana a expensas de su incremento durante la diástole tardía. Estos cambios pueden ser cuantificados y empleados como método diagnóstico de alta sensibilidad y especificidad


Subject(s)
Humans , Diastole/drug effects , Dipyridamole/pharmacology , Ventricular Dysfunction/physiopathology , Ventricular Function , Diastole/physiology , Ventricular Function/physiology
12.
Arq. bras. cardiol ; 56(4): 323-327, abr. 1991. tab
Article in Portuguese | LILACS | ID: lil-95090

ABSTRACT

Objetivo - Comparar o efeito da ticlopidina e do dipiridamol sobre a agregaçäo e a contagem plaquetárias nos pacientes com insuficiência coronariana crônica estável. Casuística e Métodos - Foram estudados 80 pacientes com idade média de 58,3 ñ 5,8 anos, portadores de insuficiência coronariana crônica estável, divididos em dois grupos de 40 pacientes e cada grupo tratado com ticlopidina ou dipiridamol. A agreagaçäo e contagem de plaquetas foram realizadas antes do início das drogas, e na primeira e quarta semanas de tratamento. Resultados - Ao final da quarta semana de tratamento observou-se hipogregabilidades espontânea, induzida pelo aDP e pela adrenalina em, respectivamente, 82,5%, 72,5% e 67,5% dos pacientes do grupo dipiridamol, a hipoagregabilidade espontânea, induzida pelo aDO e pela adrenalina foi, respectivamene, de 40%, 30% e 27,5% (p < 0,001). A contagem das plaquetas permaneceu inalterada para ambos os grupos. Conclusäo - O efeito antiagregante plaquetário da ticlopidina é significantemente maior que o do dipiridamol, e pode ser droga alternativa na prevençäo de complicaçöes cardiovasculares


Subject(s)
Humans , Male , Female , Ticlopidine/therapeutic use , Coronary Disease/drug therapy , Dipyridamole/therapeutic use , Platelet Aggregation , Platelet Count/drug effects , Ticlopidine/pharmacology , Clinical Trials as Topic , Dipyridamole/pharmacology
13.
Bol. Hosp. San Juan de Dios ; 37(6): 402-8, nov.-dic. 1990. tab
Article in Spanish | LILACS | ID: lil-96758

ABSTRACT

Diversas condiciones clínicas impiden efectuar ejercicio isotónico en correa sin fin o bicicleta ergométrica en casos en los que la evolución no invasiva de la insuficiencia coronaria es importante con fines diagnósticos o pronósticos o para evaluar los resultados de tratamientos médicos o quirúrgicos. El dipiridamol, droga que tiene potente acción vasodilatadora mediada por un aumento del nivel circulante dde adenosina, asociado a marcadores radioactivos de perfusión coronaria (Talio-201; isonitrilo Tc-99m) ha demostrado ser una alternativa muy útil y segura cuyo rendimiento es comparable con la técnica Talio-ejercicio. El dipiridamol produce vasodilatación y aumenta 3 a 5 veces el flujo coronario por espacio de 30 a 60 minutos, lo que permite evidenciar áreas miocárdicas hipoperfundidas. La seguridad de la prueba dipiridamol-Talio es muy grande. No obstante suele desencadenar angina y alteraciones isquémicas del electrocardiograma, los que se antagonizan rápida y totalmente con aminofilina


Subject(s)
Humans , Cardiomyopathies/diagnosis , Coronary Disease/diagnosis , Dipyridamole/pharmacology , Thallium/pharmacology , Dipyridamole , Dipyridamole/administration & dosage , Thallium , Thallium/administration & dosage
14.
Arq. bras. cardiol ; 52(4): 193-196, abr. 1989. tab
Article in Portuguese | LILACS | ID: lil-86972

ABSTRACT

Dezoito doentes do sexo masculino, com idades de 42 a 72 anos (média 60,6), com aterosclerose coronária confirmada à cinecoronariografia, em programa de reabilitaçäo e que faziam uso regular de dipiridamol, foram submetidos a três testes ergométricos: controle (TE1) e 40 minutos após a administraçäo oral de dipiridamol macerado, nas doses de 150 mg (TE2) e 300 mg (TE3), respectivamente. A comparaçäo dos dados do TE2 e do TE1 mostrou que no TE2 foi maior o infradesnivelamento do segmento ST na menor carga máxima atingida e também no pico do esforço. A comparaçäo dos dados do TE3 com os do TE1 revelou que no TE3: 1) o infradesnivelamento do segmento ST foi maior no pico do esforço e na menor carga máxima atingida; 2) a freqüência cardíaca atingida e o produto FC x PA no pico do esforço foram menores; 3) o tempo total de angina e o tempo para seu desaparecimento, após esforço, foram maiores. As demais variáveis näo sofreram modificaçöes significativas. Estes dados sugerem que a sobrecarga do exercício físico, após a administraçäo de dipiridamol, desencadeou grau mais acentuado de isquemia miocárdica, cuja intensidade foi proporcional a dose utilizada


Subject(s)
Humans , Male , Adult , Middle Aged , Dipyridamole/pharmacology , Exercise Test , Dipyridamole/administration & dosage , Administration, Oral , Coronary Artery Disease/physiopathology , Heart Rate
16.
Botucatu; s.n; 1988. 89 p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-201687

ABSTRACT

O presente experimento foi realizado com a finalidade de verificar a açäo da heparina, da associaçäo da heparina com o ácido acetilsalicílico (AAS) e dipiridamol, e da fístula arteriovenosa como tratamento auxiliares na prevençäo da retrombose venosa após trombectomia, em condiçöes de fluxo sangüíneo venoso diminuído. Em 48 coelhos machos foi induzida a trombose na veia jugular externa esquerda e suas tributárias pela injeçäo de trombina em um segmento venoso, no qual o fluxo sangüíneo foi interrompido por 10 minutos. Após 48 horas essas veias foram desobstruídas por meio de trombectomia com auxílio do cateter de Fogarty, sendo os coelhos em seguida distribuídos por sorteio em 4 grupos de 12 animais: Grupo1- controle- no qual todos os tempos cirúrgicos dos demais grupos foram realizados, exceto a confecçäo da fístula arteriovenosa e ministraçäo de drogas; Grupo2 - nos animais foi ministrada a heparina sódica (600 UI/Kg) via subcutânea a cada 8 horas, iniciada 30 minutos antes da trobectomia; Grupo3- nestes, além da heparina ministrada no mesmo esquema do grupo2, foi associado o AAS e o dipiridamos, via intramuscular, respectivamente nas doses de 10 mg/kg de peso uma vez por dia e 0,5 mg;kg de peso, repetida a cada 8 horas; Grupo4- nos animais, após a trombectomia, foi feita uma fístula arteriovenosa entre a artéria carótida esquerda e a veia maxilar esquerda. Os coelhos foram avaliados 48 horas após a trombectomia.


Subject(s)
Animals , Male , Rabbits , Arteriovenous Fistula , Aspirin/pharmacology , Dipyridamole/pharmacology , Heparin/pharmacology , Thrombectomy/adverse effects , Thrombophlebitis , Aspirin , Aspirin/therapeutic use , Dipyridamole , Dipyridamole/therapeutic use , Heparin , Heparin/therapeutic use , Thrombophlebitis/drug therapy
17.
Arq. bras. cardiol ; 45(3): 167-173, set. 1985. ilus, tab
Article in Portuguese | LILACS | ID: lil-27614

ABSTRACT

O dipiridamol foi usado por via intravenosa lenta (5 min), na dose de 0,3 mg/kg de peso, durante estudo hemodinâmico e cineangiocardiográfico, em 21 pacientes, 15 homens e 6 mulheres, com média de idade de 52 + ou - 9 anos e diagnóstico de cardiopatia isquêmica aterosclerótica. Foram estudados os índices do desempenho funcional do ventrículo esquerdo (VE) e a motilidade segmentar de suas paredes, quer em situaçäo basal, quer aos 5 minutos após o uso do medicamento, verificando-se: 1) Aumento da velocidade máxima de encurtamento do elemento contrátil (V max.), do débito cardíaco (DC) e do volume sistólico (VS) (p <0,05); 2) Ausência de alteraçöes estatísticamente significativas nas demais variáveis estudadas, bem como na motilidade dos segmentos do miocárdio ventricular esquerdo. Concluiu-se que: 1) O dipiridamol causou uma tendência a melhorar o desempenho do VE como músculo (considerando-se o aumento da V max) e como bomba (considerando-se o aumento do DC e VS), embora näo tenha alterado os demais índices de avaliaçäo do desempenho ventricular esquerdo; 2) O dipiridamol näo alterou a sinergia de contraçäo do miocárdio ventricular isquêmico


Subject(s)
Humans , Male , Female , Coronary Disease/physiopathology , Dipyridamole/pharmacology , Myocardial Contraction/drug effects , Hemodynamics/drug effects , Cardiac Output/drug effects , Heart Rate/drug effects , Heart Ventricles/drug effects , Stroke Volume/drug effects
18.
Arq. bras. cardiol ; 45(1): 27-29, jul. 1985. ilus
Article in Portuguese | LILACS | ID: lil-1616

ABSTRACT

Em 8 cäes anestesiados, foram estabelecidas preparaçöes coraçäo-pulmäo isoladas, mantendo-se a resistência periférica para assegurar pressäo arterial média constante (PA) de 80 mmHg. A artéria coronária descendente anterior (DA) foi ligada e um cateter introduzido distalmente. Foram controlados fluxo sistêmico (FS), EGG e fluxo colateral (FCCo), medido pelo cateter na DA. Estas variáveis foram estudadas antes e 5, 15 e 30 min depois da injeçäo de 10mg de dipiridamol. Os resultados obtidos demonstram que, mantendo-se a PA em 80 mmHg, o fluxo coronário permanece constante (p < 0,01) mesmo na vigência de variaçöes do fluxo sistêmico de 30 a 50% do controle. Na presente investigaçäo, näo foi possível constatar o fenômeno "steal effect" descrito para o dipiridamol


Subject(s)
Animals , Dogs , Vascular Resistance/drug effects , Dipyridamole/pharmacology , Collateral Circulation/drug effects , Coronary Disease/physiopathology , Arterial Pressure/drug effects
19.
Arq. bras. cardiol ; 44(5): 319-322, maio 1985. ilus, tab
Article in Portuguese | LILACS | ID: lil-1558

ABSTRACT

Foram estudados dez cäes mestiços, com pesos variáveis entre 12 e 21 Kg. submetidos à anestesia geral (pentobarbital sódico - 33mg/Kg de peso corporal), ventilaçäo controlada e toracotomia mediana ventral. Aberto o pericárdio, um sensor eletrognético de fluxo (Statham) foi adaptado na aorta ascendente. A artéria coronária descendente anterior foi ligada imediatamente abaixo da emergência do primeiro ramo diagonal e um cateter de calibre adequado introduzido naquela artéria imediatamente abaixo da ligadura. As seguintes variáveis foram controladas: ECG, fluxo arterial sistêmico, fluxo retrógrado coronário (colateral) e variaçöes tensionais na aorta e na artéria descendente anterior após a ligadura (pressäo coronária colateral). Todos os registros foram realizados imediatamente após a obstruçäo coronária (t0), 5 (t1) e 15 (t2) minutos após a administraçäo de 10,0 mg de dipiridamol e 5 (t3), 15 (t4) e 30 (t5) minutos após injeçäo adicional de 10,0 mg de dipiridamol. Os resultados obtidos demonstram aumento do débito sistêmico, com variaçäo estatisticamente significante do fluxo coronário colateral (p < 0,05), nos períodos estudados após administraçäo de dipiridamol. A diminuiçäo da pressäo coronária colateral, entretanto, em todos os períodos, foi proporcional à reduçäo da pressäo arterial sistêmica. Os resultados obtidos sugerem que as modificaçöes do fluxo coronário colateral se correlacionam com variaçöes agudas da pressäo arterial periférica, decorrentes da injeçäo endovenosa rápida do dipiridamol, näo dependendo do fenômeno de desvio circulatório ("steal effect")


Subject(s)
Animals , Dogs , Dipyridamole/pharmacology , Coronary Circulation/drug effects , Extracorporeal Circulation/drug effects , Coronary Vessels/physiology , Flowmeters , Arterial Pressure/drug effects
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