[Pulmonary tuberculosis associated with cutaneous and mediastinal sarcoidosis - a case report]

The association of sarcoidosis and tuberculosis is rare and its differentiation is sometimes very difficult. We report a case of a 49 years woman presenting insidious erythematous and nodular lesions of the face that histologically revealed non caseating granulomas of the dermis and diagnosed as cutaneous sarcoidosis. We have concomitantly diagnosed evolutive pulmonary and nasal tuberculosis treated during 2 months with isoniazid, rifampicin, pyrazinamid and streptomycin and for 6 months with isoniazid and rifampicin. The evolution of nasal obstruction was favorable and pulmonary bacteriologic examination was negative at two months treatment but mediastinal adenopathy and cutaneous lesions were unchanged. The patient was treated with Isotretinoin 60 mg daily during 6 months inducing regression of cutaneous lesions but adenopathy still unchanged. At 8-months follow-up the patient is still free of cutaneous recurrence. In our patient cutaneous sarcoidosis appeared concomitantly with evolutive tuberculosis raising further questions about the role of mycobacterium in causing this granulomatous disorder. In addition cutaneous nodules responded to isotretinoin suggesting that this drug can be useful in cutaneous sarcoidosis

Le sarcome d'Ewing: etude retrospective de 108 cas avec revue de la litterature

108 cases of ewing,s sarcoma are collected at the "curie institute" and studied by the authors using the modern technics of electron microscopy, cytochemistry, immunohisto - chemistry and cytongenetics. They raise the histogenesis and etiological factors not entirely resolved yet at the light of literature review