Intra-articular aprotinin versus steroids in osteoarthritis of the knee

The results of intra-articular Injection of aprotinin and corticosteroids have been assessed by a double-blind trial design in 32 symptomatic osteoarthritic knees. Aprotinin produced a better and longer-lasting symptomatic relief than steroids. Whereas steroids are used only for symptomatic relief in osteoarthritis, aprotinin may in addition effect a genuine cure of the diseased joint through inhibition of the proteolytic enzymes responsible for carticlage breakdown

Stimulation of tissue repair by ultrasound effect on venous leg ulceration

Twenty eight patients with chronic venous ulcers of the leg were divided into two matching groups. Ulcers in [Group "A"] were irradiated with ultrasound three times/week for 16 weeks, while ulcers in [Group "B"] were mock-insonated using a disconnected transducer for the same period and acted as controls. The ulcer area were measured every 2 weeks. Insonated ulcers [Group "A"] showed continuous decrease in their surface area. Furthermore, 50% of then healed completely before the 14th week while 71% healed before the. 16th week of treatment, The mock-insonated ulcers [Group "B"] showed minimal decrease in their surface and none of them healed at the 16th week of treatment. In conclusion, ultrasound have a remarkable therapeutic value in stimulating tissue repaire in venous ulcerations of the leg