Effect of bromocriptine on pregnancy

In the infertility clinic of Abha Hospital which is affiliated to Abha Medical School of King Saud University, 20 hyperprolactinaemic patients became pregnant after receiving treatment with the dopamine agonist bromocryptine. The bromocryptine was used until the 36th week of pregnancy and was then stopped. All the pregnancies except one, continued uneventfully until term and resulted in normal babies, although the methods of delivery were different. All infants were examined by a paediatrician at birth and were followed for a period varying between 6 months and 3 years. These babies have not, to date, shown any abnormality in growth or physical or intellectual abilities. The result of this small study refutes the categorical misconception which was prevailing a few years ago that bromocryptine is teratogenic and should be stopped as soon as pregnancy is diagnosed. The study also showed that bromocryptine is relatively safe even when used until the 36th week of pregnancy

Some reactions with 3-carbethoxy- 5,6-benzocoumarin and related compounds

Different 3-substituted-5,6-bcnzocoumarins were prepared. Their reactions with various reagents were discussed to compare their behaviour with that of 3-substituted coumarine

Action of grignard reagents on halogenated phthalimides

3-BENZALPHTHAL1MIDINES [VI] and [X] were obtained by interaction of benzylmagnesium chloride with corresponding phthalimides then dehydration of the resultant 3-benzyl-3-hydroxy-phthalimidines [IV] and [VIII]. Interaction of phenylmagnesium bromide and ethylrnagnesium iodide with brornoph thalimides [I] is also discussed

study on the effect of the sulphone group on imides

While n-substituted phthalimides can't undergo Perkin condensation, N-[P-tolylsulphonyl] phthalimide [Ib] react with P-nitrophenylacetic acid to give the benzal derivative [II] and with other active methylene compounds to give the anilide derivatives [IV]. With Grignard reagents [Ib] follow in some cases the normal lines as N-substituted phthalimides to give [X] and [XI]. While in other cases [Ib] gave abnormal products as [XII] and [XIII], With P,S[5] [one mole] [Ib] gives the expected monothione [Ic] which with amines gives N-substituted phthalimides [XIV]

Some reactions of mono-anddi-thio derivatives of N: N' [di-p-tolylsulphone] phthalamide

MONOTHIO -[II] and dithio-[VII] derivatives of N, N' - [di-p-tolyl-sulphone] phthalamide are prepared, interaction of [II] with different amines and hydrazine hydrate is discussed. The action of Grignard reagents on [VII] is studied and various products can be isolated

Interaction of grignard reagents with some substituted amides

Action of different Grignard reagents on o-diamide[l] is studied and various products can be isolated which through some light on the mechanism of the reaction. An abnormal behaviour was observed which may be attributed to the presence of SO[3] group in [I]