RESUMEN
Little information is available on the effects of monounsaturated fatty acid-rich [MUFA-rich] diets on the serum adipocytokine levels. The objective of this study was to determine the effects of a MUFA-rich diet on the serum levels of insulin, visfatin and IL-6 in overweight women [25.0 >/= BMI = 2.9.9]. This randomized cross-over clinical trial included 17 overweight women aged 20-50 years with a mean BMI of 27.6 +/- 2 kg/m[2]. The participants were randomly assigned to one of two groups consuming either a saturated fat-rich [SFA-rich; 16% SFA and 8% MUFA] or a MUFA-rich [16% MUFA and 8% SFA] diet for 6 weeks, with a 2-week washout period between the 2 periods. The percentages of energy derived from the other macronutrients were similar in the two diets. Biochemical assessments were done at the beginning and at the end of each period. Paired t-test was used for statistical analysis. The mean proportions of MUFA intakes were 13% and 7% of the total energy intake for MUFA- and SFA-rich diets, respectively, the corresponding values for SFA being 8.5% and 14%. The mean changes in the serum visfatin, insulin and IL-6 levels were not significantly different between the two diet periods; however, for serum visfatin levels, the difference [0.7 +/- 0.5 vs 0.4 +/- 0.4 nanogr/ml] was marginally significant [P=0.08]. Adjustment for potential confounders did not alter these findings [P=0.1]. The difference between the two diets as regards their effects on the serum insulin and adipocytokine levels did not reach statistical significanec [it was only marginal]. We recommend conducting long-term interventional studies with larger sample sizes to be able to draw more definite conclusions
Asunto(s)
Humanos , Femenino , Nicotinamida Fosforribosiltransferasa/sangre , Insulina/sangre , Interleucina-6/sangre , Ácidos Grasos Monoinsaturados , Estudios Cruzados , Distribución AleatoriaRESUMEN
High prevalence of depressive disorder and its disabling effects probably result in adverse effect on normal growth of fetus and on birth growth indices of newborns. Most importantly, their postnatal quality of life may be affected by these indices. This study was performed to compare birth growth indices between newborns of depressed and non-depressed women. This descriptive-analytical, prospective and cohort study was carried out on 320 pregnant women from Najafabad city during the third trimester using simple randomization. By using standard Beck depressive scale test, the women were assessed for depression. Subsequently, the information about the birth growth indices of their newborns were obtained from their family files after delivery. By using, t and x[2] tests, the data was analyzed. The prevalence of depression in pregnant women was 29.3% and it had a significant relationship with unwanted pregnancy [p<0.01] but it wasn't related to age, previous abortion, physical illness and demographic characteristics. The means of weight, height and head circumference at birth in newborns from depressed women were significantly lower than those of non-depressed women [p<0.001]. The means of growth indices in newborns from depressed women were significantly lower than those of non-depressed women. Thus, the depressed mothers should be considered more than the others by health and medical system