[Effect of orally administered ivermectin on some blood haematological and biochemical factors in donkeys [Eqqus asinus]]

Five healthy adult male Iranian donkeys [Equus asinus] were selected and Ivermectin [0.2,0.6 and 0.9 mg/kg, orally at different times] for 14 days was administered. Before dosing, control blood samples were taken on day 0. Blood samples were taken on days 1,2,3,7 and 14 following ivermectin administration at different doses. The results showed that the activity of serum AST and LDH increased on days 7 and 14 following ivermectin [0.2, 0.6 and 0.9 mg/kg, orally] administration [p<0.05]. ALP activity and BUN concentration increased significantly on day 14 following ivermectin [0.2, 0.6 and 0.9 mg/kg, orally] administration [p<0.05]. Changes of ablumin, creatinin,glucose, total protein, Phosphorous and calcium concentrations and hemoglobin, PCV, MCH, MCHC, MCV and percentages of neutrophils, eosinophils, monocytes, lymphocytes and platelet numbers were not significant [p>0.05]. As it was shown in short term, no abnormal clinical and laboratory findings were detected following different oral doses of ivermectin and it seems that the drug can be safely administered to this species

Effect of dried garlic powder [allium sativum] on lead content of different tissues following subclinical lead poisoning in goats

Efficacy of garlic [Allium sativum] to reduce tissue lead concentration was evaluated experimentally in goats. Eight crossbred female goats, randomly divided into two groups [A and B] were used. Goats of groups A and B received lead acetate orally at the dose of 80 mg/kg body weight, daily for 5 days. At the end of the period, goats of group B received dried garlic powder at the dose of 45 g/day/animal, orally for 5 days. Goats of group A served as lead exposed untreated controls. Comparison between mean lead concentrations of serum, urine and different tissues [bone, lung, heart, liver, kidney and skeletal muscle] of group A and B at the end of experiment showed respectively 69.6, 32.35,46.7, 34.2,27, 24.8, 9.6 and 46.6 percent reduction in group B [P<0.05]. Use of garlic dry powder following subclinical lead poisoning in goats was found to reduce tissue lead concentration considerably indicating the potential therapeutic activity of garlic against lead toxicity in goats