case report of newborn with thrombocytosis born to an opioid-addict mother

Neonatal thrombocytosis is a very rare phenomenon in infants born to addict mothers. It can be due to opioids withdrawal and occurs a few days after delivery. The etiology is unknown and it is eradicated gradually without any complication. The reported neonate was born to a heroin addict mother who has used methadone during pregnancy. The neonate was admitted in 14th day of life in neonatal intensive care unit [NICU] with the diagnosis of withdrawal syndrome and supportive care was administered for him. Thrombocytosis was detected in routine lab tests. There was not any reason for it except his mother's addiction. The platelet count was 1,168,000 in the first day and decreased gradually during 28 days to 739,000. There was not any complication and no special treatment was administered. This case indicates that thrombocytosis may happen as a part of neonatal abstinence syndrome and is eradicated without any complication

Congenital self healing cutaneous langerhans cell histiocytosis with multiple hypopigmented macules after recovery in a neonate

Langerhans cell histiocytosis [LCH] is the most common type of childhood histiocytic disorder with an incidence of 0.2 to 1 per 100,000 children under the age of 15 years [1]. The clinical picture of LCH varies from single system [S-S]bone or skin disease to multi-system disease [M-S] [2]. We report a neonate with disseminated papulonodular eruption containing mononuclear CD1a and S100 positive histiocytic cells infiltration at epidermis and underlying dermis. The diagnosis of a congenital self healing Langerhans cell histiocytosis [CSHLCH] was made and follow up showed a complete recovery of the eruptions, leaving hypopigmented macules in the sites corresponding to the initial findings

Clinical features and treatment response of immune thrombocytopenic purpura in infants

Pediatric immune thrombocytopenic purpura [ITP] typically manifests as isolated thrombocytopenia and mucocutaneous bleeding. We performed this study to determine the clinical features and treatment outcomes of infant with ITP. Retrospective analysis of 96 infant ITP patients treated from 1995 to 2005. The data abstracted comprised age, gender, clinical features, and treatment outcomes. The 56 male and 40 female infants had a median age of 3 months. Eighty presented with purpura, sixteen with active mucosal bleeding. The median platelet count was 13000 /ul. Seventy-seven infants received intravenous immunoglobulin [IVIG], eighteen steroids and one patient was observed. Ninty-sex [96%] responds to a single course of treatment. Infant with ITP respond favorably to treatment