RESUMEN
Lapacho is a herb that use for the treatment in herbal medicine of brezil, America and Europe. The FDA gave Lapacho a clean bill of health in 1981. The medicinal part of the tree is the bark. The active ingredient of lapacho is called lapachol. [3-7%] Te comella undulate is a species of bignoriaceae distributed in south of Iran that contains of 2-7% lapachol. This study compares topical extract of tecomella undulata bark with topical diclofenac in the knee asteorthritis. The clinical trial study was double blind patients with primary knee osteoarthritis were recruited using strict inclusion and exclusion criteria from Shiraz medical school clinics. All patients received topical agent. In group A received alcholic extract of tecomella undulota bark [20%] and in group B received topical diclofenac. [4 times a day for 4 weeks]. Subjects under went 2 office visitis 4 weeks after start of treatment and 2 weeks after finish of treatment. Evaluations measure tools were NRS and WOMAC. We have shown that 4 weeks of treatment with this extract of tecomella undulata bark relieved the symptoms of primary knee osteoarthritis significantly better than the topical diclofenac solution. The percentage improvement in NRS and WOMAC subscale score that we observed with topical extract of tecomella undulata brak therapy [41-48%] were similar to those reported for oral NSAID treatment. te comell undulate extract is a safe and effective approach for knee osteoarthritis with high success rate